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:arr="{&quot;content&quot;:[{&quot;headline&quot;:&quot;&quot;,&quot;entry&quot;:&quot;&lt;h1&gt;The Perpetual Pursuit of Precision: AI-enabled Functional Testing&lt;\/h1&gt;\n&lt;p&gt;Certis continues to conduct observational clinical research studies aimed at further validating the application of \u201c&lt;a href=\&quot;https:\/\/en.wikipedia.org\/wiki\/Mouse_avatars\&quot; target=\&quot;_blank\&quot; rel=\&quot;noopener\&quot;&gt;mouse avatars&lt;\/a&gt;\u201d as a clinically relevant platform for precision oncology. Study protocols enable us to simultaneously evaluate the clinical utility of our patent-pending &lt;strong&gt;CertisAI\u2122&lt;\/strong&gt; platform, which uses gene expression biomarkers and multivariate analyses to predict individual drug response to multiple therapeutic options.&lt;\/p&gt;\n&quot;,&quot;cta&quot;:{&quot;title&quot;:&quot;LEARN MORE&quot;,&quot;url&quot;:&quot;https:\/\/www.soteriaprecisionmedicine.org\/certisoncology&quot;,&quot;target&quot;:&quot;_blank&quot;}}],&quot;media-option&quot;:&quot;image&quot;,&quot;image&quot;:{&quot;image&quot;:{&quot;ID&quot;:6089,&quot;id&quot;:6089,&quot;title&quot;:&quot;Hero - Static 3 - R3-2168x928-optimized&quot;,&quot;filename&quot;:&quot;Hero-Static-3-R3-2168x928-optimized.webp&quot;,&quot;filesize&quot;:217688,&quot;url&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized.webp&quot;,&quot;link&quot;:&quot;https:\/\/www.certisoncology.com\/for-oncologists\/clinical-research\/hero-static-3-r3-2168x928-optimized\/&quot;,&quot;alt&quot;:&quot;&quot;,&quot;author&quot;:&quot;6&quot;,&quot;description&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;name&quot;:&quot;hero-static-3-r3-2168x928-optimized&quot;,&quot;status&quot;:&quot;inherit&quot;,&quot;uploaded_to&quot;:5923,&quot;date&quot;:&quot;2024-01-24 19:50:02&quot;,&quot;modified&quot;:&quot;2024-01-26 20:02:30&quot;,&quot;menu_order&quot;:0,&quot;mime_type&quot;:&quot;image\/webp&quot;,&quot;type&quot;:&quot;image&quot;,&quot;subtype&quot;:&quot;webp&quot;,&quot;icon&quot;:&quot;https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png&quot;,&quot;width&quot;:2168,&quot;height&quot;:928,&quot;sizes&quot;:{&quot;thumbnail&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-150x150.webp&quot;,&quot;thumbnail-width&quot;:150,&quot;thumbnail-height&quot;:150,&quot;medium&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-720x308.webp&quot;,&quot;medium-width&quot;:300,&quot;medium-height&quot;:128,&quot;medium_large&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-768x329.webp&quot;,&quot;medium_large-width&quot;:768,&quot;medium_large-height&quot;:329,&quot;large&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-960x411.webp&quot;,&quot;large-width&quot;:960,&quot;large-height&quot;:411,&quot;1536x1536&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-1536x657.webp&quot;,&quot;1536x1536-width&quot;:1536,&quot;1536x1536-height&quot;:657,&quot;2048x2048&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-2048x877.webp&quot;,&quot;2048x2048-width&quot;:2048,&quot;2048x2048-height&quot;:877,&quot;small&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-540x231.webp&quot;,&quot;small-width&quot;:540,&quot;small-height&quot;:231,&quot;square-sm&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-540x540.webp&quot;,&quot;square-sm-width&quot;:540,&quot;square-sm-height&quot;:540,&quot;square-md&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-720x720.webp&quot;,&quot;square-md-width&quot;:720,&quot;square-md-height&quot;:720,&quot;portrait&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-640x920.webp&quot;,&quot;portrait-width&quot;:640,&quot;portrait-height&quot;:920,&quot;landscape&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Hero-Static-3-R3-2168x928-optimized-960x640.webp&quot;,&quot;landscape-width&quot;:960,&quot;landscape-height&quot;:640}},&quot;href&quot;:&quot;&quot;,&quot;title&quot;:&quot;Sponsored Research &quot;,&quot;description&quot;:&quot;&lt;p&gt;Sponsored studies at the Certis&lt;sup&gt;\u00ae&lt;\/sup&gt; CLIA-certified laboratory currently focus on colorectal and other types of cancer that carry common KRAS mutations. Each participant\u2019s personalized clinical research study includes the simultaneous testing of up to four therapeutic options, using five orthotopically engrafted PDX models as patient avatars in each study arm.&lt;\/p&gt;\n&quot;},&quot;video-service&quot;:&quot;&quot;,&quot;video&quot;:{&quot;id&quot;:&quot;&quot;,&quot;title&quot;:&quot;&quot;,&quot;description&quot;:&quot;&quot;},&quot;layout&quot;:{&quot;background-color&quot;:&quot;white&quot;,&quot;direction&quot;:&quot;left to right&quot;,&quot;vertical-align&quot;:&quot;top&quot;}}"></component-5f7cbffb57673><component-5f6e3c3648fee :arr="{&quot;headline&quot;:&quot;&quot;,&quot;content&quot;:&quot;&lt;h2&gt;SOTERIA and Certis Team Up&lt;\/h2&gt;\n&lt;p&gt;Clinical research studies sponsored by SOTERIA Precision Medicine Foundation are funded by charitable donations. We\u2019re currently engaged in evaluating KRAS mutations in colorectal cancers, and to assess concordance across CertisAI\u2122 predictions, patient-derived xenograft orthotopic models and cancer patients. Results from the study may be used to help validate the use of new combinatorial therapies to treat KRAS-mutated cancers. The study will build on early evidence that suggests the repurposing of existing, FDA-approved drugs not currently indicated for colorectal cancers may improve clinical outcomes for individuals with KRAS-dysregulated cancers.&lt;\/p&gt;\n&lt;p&gt;Functional oncology assays can help address the limitations of mainstream clinical practice by providing immediately translatable, personalized information to guide individualized therapy.&lt;span class=\&quot;tooltip\&quot;&gt;&lt;sup id=\&quot;3996\&quot;&gt;1&lt;\/sup&gt;&lt;\/span&gt;&lt;\/p&gt;\n&quot;,&quot;cta&quot;:{&quot;title&quot;:&quot;DOWNLOAD DONOR 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19:54:01&quot;,&quot;menu_order&quot;:0,&quot;mime_type&quot;:&quot;image\/webp&quot;,&quot;type&quot;:&quot;image&quot;,&quot;subtype&quot;:&quot;webp&quot;,&quot;icon&quot;:&quot;https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png&quot;,&quot;width&quot;:720,&quot;height&quot;:540,&quot;sizes&quot;:{&quot;thumbnail&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized-150x150.webp&quot;,&quot;thumbnail-width&quot;:150,&quot;thumbnail-height&quot;:150,&quot;medium&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized.webp&quot;,&quot;medium-width&quot;:300,&quot;medium-height&quot;:225,&quot;medium_large&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized.webp&quot;,&quot;medium_large-width&quot;:720,&quot;medium_large-height&quot;:540,&quot;large&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized.webp&quot;,&quot;large-width&quot;:720,&quot;large-height&quot;:540,&quot;1536x1536&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized.webp&quot;,&quot;1536x1536-width&quot;:720,&quot;1536x1536-height&quot;:540,&quot;2048x2048&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized.webp&quot;,&quot;2048x2048-width&quot;:720,&quot;2048x2048-height&quot;:540,&quot;small&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized-540x405.webp&quot;,&quot;small-width&quot;:540,&quot;small-height&quot;:405,&quot;square-sm&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized-540x540.webp&quot;,&quot;square-sm-width&quot;:540,&quot;square-sm-height&quot;:540,&quot;square-md&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized.webp&quot;,&quot;square-md-width&quot;:720,&quot;square-md-height&quot;:540,&quot;portrait&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized-640x540.webp&quot;,&quot;portrait-width&quot;:640,&quot;portrait-height&quot;:540,&quot;landscape&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Observational-Clinical-Research-Study-Certis-Oncology-optimized.webp&quot;,&quot;landscape-width&quot;:720,&quot;landscape-height&quot;:540}},&quot;href&quot;:&quot;&quot;,&quot;title&quot;:&quot;Paving the Way for Functional Precision Oncology&quot;,&quot;description&quot;:&quot;&lt;p&gt;SOTERIA Precision Medicine Foundation, a not-for-profit, tax-exempt organization dedicated to empowering patients, caregivers, and clinicians with the power of precision medicine. &lt;\/p&gt;\n&quot;},&quot;video-service&quot;:&quot;&quot;,&quot;video&quot;:{&quot;id&quot;:&quot;&quot;,&quot;title&quot;:&quot;&quot;,&quot;description&quot;:&quot;&quot;},&quot;layout&quot;:{&quot;background-color&quot;:&quot;gray&quot;,&quot;direction&quot;:&quot;left to right&quot;,&quot;vertical-align&quot;:&quot;top&quot;}}"></component-5f6e3c3648fee><component-5f6e4355bed24 :arr="{&quot;content&quot;:&quot;&lt;p style=\&quot;text-align: left;\&quot;&gt;Certis is currently engaged with\u2014 and interested in partnering with\u2014 US-based healthcare institutions to bring AI-directed, personalized functional oncology assays to the fight against cancer. Please reach out to us if your institution currently treats cancer patients and is interested in transforming cancer care.&lt;\/p&gt;\n&lt;p style=\&quot;text-align: center;\&quot;&gt;&lt;img fetchpriority=\&quot;high\&quot; decoding=\&quot;async\&quot; class=\&quot; wp-image-6098\&quot; src=\&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Icon_doctor-patient-conversation-2-optimized-720x720.webp\&quot; alt=\&quot;doctor-patient-conversation\&quot; width=\&quot;224\&quot; height=\&quot;224\&quot; \/&gt;&lt;\/p&gt;\n&lt;p&gt;An Institutional Review Board (IRB) is an administrative body established to protect the rights and welfare of human research subjects recruited to participate in research activities. In accordance with FDA regulations, the IRB is charged with the responsibility of reviewing, prior to its initiation, all research involving human participants. The IRB has the authority to approve, exempt, disapprove, monitor, and require modifications in all research activities that fall within its jurisdiction as specified by both the federal regulations and institutional policy.&lt;\/p&gt;\n&quot;,&quot;callout&quot;:{&quot;headline&quot;:&quot;The Power of Institutional Partnerships&quot;,&quot;content&quot;:&quot;&quot;,&quot;image&quot;:false},&quot;layout&quot;:{&quot;background&quot;:&quot;cells&quot;,&quot;style&quot;:&quot;card&quot;,&quot;columns&quot;:&quot;12&quot;,&quot;callout-columns&quot;:&quot;2&quot;}}"></component-5f6e4355bed24><component-5f7cbffb57673 :arr="{&quot;content&quot;:[{&quot;headline&quot;:&quot;&quot;,&quot;entry&quot;:&quot;&lt;h2&gt;Donations are Tax-Deductible&lt;\/h2&gt;\n&lt;p&gt;We can\u2019t achieve our goals without the generosity and dedication of supporters like you. Every step we take brings us closer to a future where we can make a significant impact on the lives of cancer patients and their families.&lt;\/p&gt;\n&lt;p&gt;Funds raised for this clinical cancer research study will provide each participant with a personalized, no-cost study that combines genomic profiling with predictive AI and advanced functional testing. In addition to helping to inform participants\u2019 next-line treatment, data collected through this study could impact thousands of other cancer patients in the future.&lt;\/p&gt;\n&lt;p&gt;ATTN: Certis Oncology&lt;br \/&gt;\nSOTERIA Precision Medicine Foundation, Inc.&lt;br \/&gt;\nPO Box 3314&lt;br \/&gt;\nLa Jolla CA 92038&lt;\/p&gt;\n&lt;p&gt;SOTERIA Precision Medicine Foundation is a 501(c)3 nonprofit, EIN 82-0642928. All donations received by SOTERIA to support this Project will be placed into a restricted fund devoted to the purposes of and for the sole benefit of this Project&#8217;s mission. We will send receipts for your tax-deductible donation via email and to the mailing address you provide within 30 days.&lt;\/p&gt;\n&quot;,&quot;cta&quot;:{&quot;title&quot;:&quot;DONATE TODAY&quot;,&quot;url&quot;:&quot;https:\/\/donate.stripe.com\/00g154cUU3uI1iw7ss?&quot;,&quot;target&quot;:&quot;_blank&quot;}}],&quot;media-option&quot;:&quot;image&quot;,&quot;image&quot;:{&quot;image&quot;:{&quot;ID&quot;:6113,&quot;id&quot;:6113,&quot;title&quot;:&quot;Arthur_White-edit-optimized&quot;,&quot;filename&quot;:&quot;Arthur_White-edit-optimized.webp&quot;,&quot;filesize&quot;:126958,&quot;url&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized.webp&quot;,&quot;link&quot;:&quot;https:\/\/www.certisoncology.com\/for-oncologists\/clinical-research\/arthur_white-edit-optimized\/&quot;,&quot;alt&quot;:&quot;&quot;,&quot;author&quot;:&quot;6&quot;,&quot;description&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;name&quot;:&quot;arthur_white-edit-optimized&quot;,&quot;status&quot;:&quot;inherit&quot;,&quot;uploaded_to&quot;:5923,&quot;date&quot;:&quot;2024-01-24 20:34:30&quot;,&quot;modified&quot;:&quot;2024-01-24 20:34:30&quot;,&quot;menu_order&quot;:0,&quot;mime_type&quot;:&quot;image\/webp&quot;,&quot;type&quot;:&quot;image&quot;,&quot;subtype&quot;:&quot;webp&quot;,&quot;icon&quot;:&quot;https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png&quot;,&quot;width&quot;:1200,&quot;height&quot;:904,&quot;sizes&quot;:{&quot;thumbnail&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-150x150.webp&quot;,&quot;thumbnail-width&quot;:150,&quot;thumbnail-height&quot;:150,&quot;medium&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-720x542.webp&quot;,&quot;medium-width&quot;:300,&quot;medium-height&quot;:226,&quot;medium_large&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-768x579.webp&quot;,&quot;medium_large-width&quot;:768,&quot;medium_large-height&quot;:579,&quot;large&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-960x723.webp&quot;,&quot;large-width&quot;:960,&quot;large-height&quot;:723,&quot;1536x1536&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized.webp&quot;,&quot;1536x1536-width&quot;:1200,&quot;1536x1536-height&quot;:904,&quot;2048x2048&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized.webp&quot;,&quot;2048x2048-width&quot;:1200,&quot;2048x2048-height&quot;:904,&quot;small&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-540x407.webp&quot;,&quot;small-width&quot;:540,&quot;small-height&quot;:407,&quot;square-sm&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-540x540.webp&quot;,&quot;square-sm-width&quot;:540,&quot;square-sm-height&quot;:540,&quot;square-md&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-720x720.webp&quot;,&quot;square-md-width&quot;:720,&quot;square-md-height&quot;:720,&quot;portrait&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-640x904.webp&quot;,&quot;portrait-width&quot;:640,&quot;portrait-height&quot;:904,&quot;landscape&quot;:&quot;https:\/\/www.certisoncology.com\/wp-content\/uploads\/Arthur_White-edit-optimized-960x640.webp&quot;,&quot;landscape-width&quot;:960,&quot;landscape-height&quot;:640}},&quot;href&quot;:&quot;&quot;,&quot;title&quot;:&quot; Cancer Thriver &amp; Study Participant Arthur White&quot;,&quot;description&quot;:&quot;&lt;p&gt;\u201cThe patient-centric nature is what this process is all about,\u201d says Cancer Thriver &amp; Study Participant Arthur White. The SOTERIA fundraising event in partnership with Certis Oncology Solutions took place at the Marine Room in La Jolla, CA. &lt;\/p&gt;\n&quot;},&quot;video-service&quot;:&quot;&quot;,&quot;video&quot;:{&quot;id&quot;:&quot;&quot;,&quot;title&quot;:&quot;&quot;,&quot;description&quot;:&quot;&quot;},&quot;layout&quot;:{&quot;background-color&quot;:&quot;white&quot;,&quot;direction&quot;:&quot;left to right&quot;,&quot;vertical-align&quot;:&quot;top&quot;}}"></component-5f7cbffb57673><component-5f6e40ba1bdc4 :arr="{&quot;title&quot;:&quot;&quot;,&quot;content&quot;:&quot;&quot;,&quot;headline&quot;:&quot;Clinical Cancer Research Study: Answers to Frequently Asked Questions &quot;,&quot;items&quot;:[{&quot;ID&quot;:6115,&quot;post_author&quot;:&quot;6&quot;,&quot;post_date&quot;:&quot;2024-01-24 20:39:25&quot;,&quot;post_date_gmt&quot;:&quot;2024-01-24 20:39:25&quot;,&quot;post_content&quot;:&quot;\n&lt;p&gt;The United States health care system relies upon a set of protocolized standard of care (SoC) guidelines that recommend treating whole populations of patients based largely on tumor site, and in some cases, the existence of biomarkers and\/or genetic mutations that may or may not be driving an individual\u2019s cancer. For over 60 years, this reductionist approach to cancer treatment has produced outcome failure-rates of 90% (\u00b15).&lt;span class=&#8221;tooltip&#8221;&gt;&lt;sup id=&#8221;3996&#8243;&gt;1&lt;\/sup&gt;&lt;\/span&gt;\u00a0If SoC therapy fails, people with cancer generally undergo a series of trial-and-error treatments that often lead to toxic side effects, a diminished immune system, emotional stress, and financial hardship. Not only does this process harm patients, it creates unnecessary expense within an already cost-burdened healthcare system.&lt;br&gt;&lt;br&gt;&lt;strong&gt;1&lt;\/strong&gt; Letai A, Bhola P, Welm A. &lt;a href=\&quot;https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3996\&quot; target=\&quot;_blank\&quot; rel=\&quot;noreferrer noopener\&quot;&gt;Functional Precision Oncology: Testing Tumors with Drugs to Identify Vulnerabilities and Novel Combinations&lt;\/a&gt;. &lt;em&gt;Cancer Cell&lt;\/em&gt;. 2022;49(1):26-35.&lt;\/p&gt;\n&quot;,&quot;post_title&quot;:&quot;Why is this sponsored clinical cancer research study important?&quot;,&quot;post_excerpt&quot;:&quot;&quot;,&quot;post_status&quot;:&quot;publish&quot;,&quot;comment_status&quot;:&quot;closed&quot;,&quot;ping_status&quot;:&quot;closed&quot;,&quot;post_password&quot;:&quot;&quot;,&quot;post_name&quot;:&quot;why-is-this-sponsored-clinical-cancer-research-study-important&quot;,&quot;to_ping&quot;:&quot;&quot;,&quot;pinged&quot;:&quot;&quot;,&quot;post_modified&quot;:&quot;2024-02-28 00:04:25&quot;,&quot;post_modified_gmt&quot;:&quot;2024-02-28 00:04:25&quot;,&quot;post_content_filtered&quot;:&quot;&quot;,&quot;post_parent&quot;:0,&quot;guid&quot;:&quot;https:\/\/www.certisoncology.com\/?post_type=type-faqs&#038;p=6115&quot;,&quot;menu_order&quot;:0,&quot;post_type&quot;:&quot;type-faqs&quot;,&quot;post_mime_type&quot;:&quot;&quot;,&quot;comment_count&quot;:&quot;0&quot;,&quot;filter&quot;:&quot;raw&quot;},{&quot;ID&quot;:6119,&quot;post_author&quot;:&quot;6&quot;,&quot;post_date&quot;:&quot;2024-01-24 20:45:39&quot;,&quot;post_date_gmt&quot;:&quot;2024-01-24 20:45:39&quot;,&quot;post_content&quot;:&quot;\n&lt;p&gt;In 2022, Certis Oncology Solutions, Inc, (Certis) and Aspect Imaging, Ltd, (Aspect) launched a pilot study to test a hypothesis that Artificial Intelligence-guided, MRI-validated functional assays using personalized, orthotopic patient-derived xenograft (O-PDX) models could accurately predict therapeutic response to various treatment options, in mouse models.&lt;\/p&gt;\n\n\n\n&lt;p&gt;During the conduct of the pilot study, Certis scientists discovered intriguing biomarker patterns predictive of favorable response, in mouse models, to existing therapies not currently indicated for certain \u201cuntreatable\u201d forms of cancer. AI-enabled predictions were tested &lt;em&gt;in vivo&lt;\/em&gt;, tumor regression was measured by MRI, and results were confirmed by histology. Early findings compelled a deeper interrogation of public&lt;em&gt; in vitro&lt;\/em&gt; and clinical outcomes datasets. All findings point to an opportunity to repurpose existing, FDA-approved drugs that may improve clinical outcomes for individuals diagnosed with colorectal and other cancers with KRAS mutations, as well as other potentially actionable targets.&lt;\/p&gt;\n&quot;,&quot;post_title&quot;:&quot;How did this sponsored clinical cancer research study begin?&quot;,&quot;post_excerpt&quot;:&quot;&quot;,&quot;post_status&quot;:&quot;publish&quot;,&quot;comment_status&quot;:&quot;closed&quot;,&quot;ping_status&quot;:&quot;closed&quot;,&quot;post_password&quot;:&quot;&quot;,&quot;post_name&quot;:&quot;how-did-this-sponsored-clinical-cancer-research-study-begin&quot;,&quot;to_ping&quot;:&quot;&quot;,&quot;pinged&quot;:&quot;&quot;,&quot;post_modified&quot;:&quot;2024-01-24 20:45:39&quot;,&quot;post_modified_gmt&quot;:&quot;2024-01-24 20:45:39&quot;,&quot;post_content_filtered&quot;:&quot;&quot;,&quot;post_parent&quot;:0,&quot;guid&quot;:&quot;https:\/\/www.certisoncology.com\/?post_type=type-faqs&#038;p=6119&quot;,&quot;menu_order&quot;:0,&quot;post_type&quot;:&quot;type-faqs&quot;,&quot;post_mime_type&quot;:&quot;&quot;,&quot;comment_count&quot;:&quot;0&quot;,&quot;filter&quot;:&quot;raw&quot;},{&quot;ID&quot;:6120,&quot;post_author&quot;:&quot;6&quot;,&quot;post_date&quot;:&quot;2024-01-24 20:46:59&quot;,&quot;post_date_gmt&quot;:&quot;2024-01-24 20:46:59&quot;,&quot;post_content&quot;:&quot;\n&lt;p&gt;This Project may benefit participants for whom no standard-of-care option is available by providing treating oncologists with hypothesis-generating drug sensitivity data that may help inform next-line treatment decisions. If AI-identified predictive biomarkers are validated &lt;em&gt;in vivo&lt;\/em&gt;, results from this Project also may inform future clinical trials to determine whether using already-approved drugs in combination can effectively treat subpopulations of patients with unmet needs. Ultimately, this Project will benefit all individuals who will be diagnosed with cancer in their lifetime by advancing science in both functional precision oncology and AI-enabled predictive medicine.&lt;\/p&gt;\n\n\n\n&lt;p&gt;All donations received by SOTERIA for the purposes of the clinical cancer research study will be placed into a restricted fund to be devoted to the purposes of and for the sole benefit of this Project&#8217;s mission.&lt;\/p&gt;\n&quot;,&quot;post_title&quot;:&quot;Who does this sponsored clinical cancer research study benefit?&quot;,&quot;post_excerpt&quot;:&quot;&quot;,&quot;post_status&quot;:&quot;publish&quot;,&quot;comment_status&quot;:&quot;closed&quot;,&quot;ping_status&quot;:&quot;closed&quot;,&quot;post_password&quot;:&quot;&quot;,&quot;post_name&quot;:&quot;who-does-this-sponsored-clinical-cancer-research-study-benefit&quot;,&quot;to_ping&quot;:&quot;&quot;,&quot;pinged&quot;:&quot;&quot;,&quot;post_modified&quot;:&quot;2024-01-24 20:46:59&quot;,&quot;post_modified_gmt&quot;:&quot;2024-01-24 20:46:59&quot;,&quot;post_content_filtered&quot;:&quot;&quot;,&quot;post_parent&quot;:0,&quot;guid&quot;:&quot;https:\/\/www.certisoncology.com\/?post_type=type-faqs&#038;p=6120&quot;,&quot;menu_order&quot;:0,&quot;post_type&quot;:&quot;type-faqs&quot;,&quot;post_mime_type&quot;:&quot;&quot;,&quot;comment_count&quot;:&quot;0&quot;,&quot;filter&quot;:&quot;raw&quot;}],&quot;cta&quot;:&quot;&quot;,&quot;layout&quot;:{&quot;background&quot;:&quot;&quot;,&quot;background-offset&quot;:&quot;&quot;}}"></component-5f6e40ba1bdc4><component-5f6e4355bed24 :arr="{&quot;content&quot;:&quot;&lt;p&gt;FUNCTIONAL DRUG SENSITIVITY TESTING MEASURES THERAPEUTIC RESPONSE IN ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS. TEST RESULTS ARE NOT A REPLACEMENT FOR MEDICAL ADVICE. TREATMENT DECISIONS ARE THE RESPONSIBILITY OF PATIENTS AND THEIR PHYSICIANS. FUNCTIONAL TESTING REQUIRES FRESH TUMOR TISSUE. IT IS ESSENTIAL TO CONTACT US PRIOR TO BIOPSY OR RESECTION SURGERY.&lt;\/p&gt;\n&quot;,&quot;callout&quot;:{&quot;headline&quot;:&quot;&quot;,&quot;content&quot;:&quot;&quot;,&quot;image&quot;:false},&quot;layout&quot;:{&quot;background&quot;:&quot;white&quot;,&quot;style&quot;:&quot;default&quot;,&quot;columns&quot;:&quot;12&quot;,&quot;callout-columns&quot;:&quot;2&quot;}}"></component-5f6e4355bed24><component-5f6e424bba9c9 :arr="{&quot;headline&quot;:&quot;Have a question?&quot;,&quot;description&quot;:&quot;&quot;,&quot;cta&quot;:{&quot;title&quot;:&quot;Contact Us&quot;,&quot;url&quot;:&quot;https:\/\/www.certisoncology.com\/contact-us\/&quot;,&quot;target&quot;:&quot;&quot;},&quot;layout&quot;:{&quot;background&quot;:&quot;cells&quot;,&quot;style&quot;:&quot;default&quot;,&quot;sticky&quot;:true}}"></component-5f6e424bba9c9> </div> <footer> <div class="container"> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="mb-4 mb-md-2 mb-lg-0 mr-sm-4"> <figure class="mb-3 mr-lg-6"> <img class="img-fluid d-block" src="/wp-content/themes/certis/images/certis-logo-lockup-white.svg"> </figure> <address> <div> <span class="street-address d-block">5626 Oberlin Drive, Suite 110</span> <span class="city state zip d-block mb-3">San Diego, CA 92121</span> </div> <div> <span class="phone d-block">Drug Development: 858-988-1033</span> <span class="phone d-block">Patients & Oncologists: 858-228-4110</span> <span class="phone d-block">Main: 858-952-1820</span> </div> </address> </div> <nav class="flex-grow-1"> <ul class="sections ml-0 ml-md-4"> <li> <h4 style="text-transform: uppercase;">Drug Developers</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/for-drug-developers/predictive-oncology-intelligence/">CertisAI™</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/cancer-models-preclinical-studies/">Cancer Models</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/custom-model-development/">Custom Model Development</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/in-vitro-ex-vivo-pharmacology/">In Vitro/Ex Vivo Pharmacology</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/in-vivo-pharmacology/">In Vivo Pharmacology</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/imaging-endpoint-analysis/">Imaging/Endpoint Analysis</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/immuno-oncology/">Immuno-Oncology</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">Oncologists</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/for-oncologists/order-yourpdx/">Order YourPDX<sup>®</sup></a></li> <li><a href="https://www.certisoncology.com/for-oncologists/clinical-research/">Clinical Research</a></li> <li><a href="https://www.certisoncology.com/for-oncologists/patient-education/">Patient Education</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">Resource Library</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/resources/cancer-market-facts/">Cancer Facts</a></li> <li><a href="https://www.certisoncology.com/resources/clinical-results/">Clinical Results</a></li> <li><a href="https://www.certisoncology.com/resources/supporting-research/">Supporting Research</a></li> <li><a href="https://www.certisoncology.com/resources/media/">Media</a></li> <li><a href="https://whitepapers.certisoncology.com/">White Papers</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">About</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/about-us/mission-vision-values/">Mission, Vision &#038; 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