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https://whitepapers.certisoncology.com/hs-fs/hubfs/CTA_KRAS-CertiScreen-824x424-1-720x424.jpg?width=2160&name=CTA_KRAS-CertiScreen-824x424-1-720x424.jpg 2160w" sizes="(max-width: 720px) 100vw, 720px"></span></div> </figure> <div class="card-content"> <div id="hs_cos_wrapper_card_content" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_card_content_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3>VALIDATE YOUR KRAS-TARGETING STRATEGY</h3> <p>Combining Predictive AI + Advanced Cancer Models to Help Direct Oncology Drug Development and Clinic Research Studies.</p> <a href="https://www.certisoncology.com/kras-targeted-oncology-drug-development/">LEARN MORE</a></span></div> </div> </div> </div> </div> </div> </section> </div></div> <div class="banner-section"> <div id="hs_cos_wrapper_blog_banner" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="banner_area"> <div class="page-center"> <div class="hero_banner image-listing" style="background-image:url(https://whitepapers.certisoncology.com/hubfs/hero-banner_about-1.jpg)"> <img src="https://whitepapers.certisoncology.com/hubfs/hero-headline_certainty-saves-lives.svg" alt="hero-headline_certainty-saves-lives" loading="lazy" width="234" height="76" style="max-width: 100%; height: auto;"> </div> </div> </div> <nav class="blog-cat-wrap listing"> <div class="content-wrapper"> <ul> <li class="inactive"> <a href="https://www.certisoncology.com/resources/cancer-market-facts/">Cancer Facts</a> </li> <li class="inactive"> <a href="https://www.certisoncology.com/resources/clinical-results/">Clinical Results</a> </li> <li class="inactive"> <a 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Certis Oncology (2024). The conventional drug development pipeline has delivered incredible pharmaceutical successes and blockbusters. But, recently, appreciation for the growing number of failed drug candidates that...</p> </div> <a href="https://whitepapers.certisoncology.com/advancing-translational-oncology-with-3d-cell-culture" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>Certis Oncology Solution's Self-Proclaimed Poster Boy: Jeffrey Alan Dinkin</h3> <time class="date">November 10, 2023</time> <div class="post-content"> <p>It started with back pain.</p> </div> <a href="https://whitepapers.certisoncology.com/certis-oncology-solutions-self-proclaimed-poster-boy-jeffrey-alan-dinkin" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>RAS Mutations in Cancer: Emerging Drug Development Strategies</h3> <time class="date">September 20, 2023</time> <div class="post-content"> <p>For four decades, the causal link between RAS mutations in cancer – including the KRAS, HRAS, and NRAS genes – has been well-accepted. But for almost as long, oncology drug development has struggled to develop RAS inhibitors, and many had long...</p> </div> <a href="https://whitepapers.certisoncology.com/ras-mutations-in-cancer-emerging-drug-development-strategies" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>The Power of Predictive AI Models: Revolutionizing Cancer Research</h3> <time class="date">June 07, 2023</time> <div class="post-content"> <p>Powerful computational tools, such as predictive artificial intelligence (AI) models, are reshaping preclinical research, leading to more optimized and streamlined drug discovery and drug development pipelines.1 In drug discovery, AI can be applied...</p> </div> <a href="https://whitepapers.certisoncology.com/how-predictive-ai-models-are-revolutionizing-cancer-research" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>Functional Precision Oncology: Filling the Gap Left By Genomics-Based Approaches</h3> <time class="date">June 01, 2023</time> <div class="post-content"> <p>Precision oncology (also known as personalized medicine in cancer treatment) is about matching an individual to the optimal therapy for their unique form of cancer. Many people associate personalized medicine with genetic testing. Genomic tumor...</p> </div> <a href="https://whitepapers.certisoncology.com/functional-precision-oncology" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>How to Overcome the Translation Gap in Cancer Research</h3> <time class="date">March 28, 2023</time> <div class="post-content"> <p>Custom Solutions, Better Translation The ultimate goal of drug development in oncology is to identify drug candidates that will successfully advance through the clinical trial pipeline to FDA approval, thus offering individuals with cancer the hope...</p> </div> <a href="https://whitepapers.certisoncology.com/overcoming-the-translational-gap-in-oncology-research-custom-model-development" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>Mimicking the "Seed and Soil:" The State of PDX Models of Breast Cancer Metastases</h3> <time class="date">October 27, 2022</time> <div class="post-content"> <p>Why do the quaintest analogies stick to biology’s most morbid phenomena? Look no further than English surgeon Stephen Paget’s “seed and soil” model for breast cancer metastasis for a prototypical example. In his 1889 publication in the Lancet, Paget...</p> </div> <a href="https://whitepapers.certisoncology.com/mimicking-the-seed-and-soil-the-state-of-pdx-models-of-breast-cancer-metastases" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>New Certis Whitepaper: Bringing Certainty to PDX Model Characterization</h3> <time class="date">September 28, 2022</time> <div class="post-content"> <p>EXECUTIVE SUMMARY Patient-derived xenograft (PDX) models are indispensable for translational cancer research. However, public and private PDX tumor banks may lack standard quality controls, which may lead to genomic and transcriptomic...</p> </div> <a href="https://whitepapers.certisoncology.com/new-certis-whitepaper-bringing-certainty-to-pdx-model-characterization" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>Improving Drug Development and Glioblastoma Xenograft Models</h3> <time class="date">September 19, 2022</time> <div class="post-content"> <p>Overcoming Glioblastoma Multiforme (GBM) Drug Development Challenges With Glioblastoma Xenograft Models Primary brain tumors are highly heterogeneous tumors that cause significant morbidity and mortality. An estimated 700,000 Americans are living...</p> </div> <a href="https://whitepapers.certisoncology.com/glioblastoma-xenograft-models" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item"> <h3>Developing Clinically Relevant Metastatic Colorectal Cancer Models: From Carcinogens to Xenografts</h3> <time class="date">March 23, 2022</time> <div class="post-content"> <p>Colorectal cancer (CRC) is common and deadly, making up an estimated 7.9% of all new cancer cases and 8.7% of all cancer deaths in the U.S. last year.1 Cancer mortality often results from metastasis, which for colorectal cancer, happens frequently; ...</p> </div> <a href="https://whitepapers.certisoncology.com/developing-clinically-relevant-metastatic-colorectal-cancer-models-from-carcinogins-to-xenographs" class="read-more">Read More</a> </div> </div> <div class="post-item"> <div class="inner-post-item">  <script charset="utf-8" type="text/javascript" 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