CINXE.COM
Functional Oncology Testing | Personalized Cancer Medicine
<!doctype html> <html lang="en"> <head> <meta charset="utf-8" /> <title>Functional Oncology Testing | Personalized Cancer Medicine</title> <meta name="viewport" content="width=device-width, initial-scale=1.0, maximum-scale=1.0, user-scalable=no" /> <link rel="stylesheet" media="all" href="/wp-content/themes/certis/dist/css/style.css?v2"/> <!-- google tag manager --> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-K5GS2LR');</script> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' /> <!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v23.8) - https://yoast.com/wordpress/plugins/seo/ --> <meta name="description" content="Functional oncology brings greater precision to personalized cancer medicine. Learn about YourPDX® testing to help inform next-line cancer treatment strategies." /> <link rel="canonical" href="https://www.certisoncology.com/for-oncologists/patient-education/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Patient Education" /> <meta property="og:description" content="Functional oncology brings greater precision to personalized cancer medicine. Learn about YourPDX® testing to help inform next-line cancer treatment strategies." /> <meta property="og:url" content="https://www.certisoncology.com/for-oncologists/patient-education/" /> <meta property="og:site_name" content="Certis Oncology" /> <meta property="article:publisher" content="https://www.facebook.com/CertisOncology/" /> <meta property="article:modified_time" content="2024-03-28T23:40:35+00:00" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@CertisOncology" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://www.certisoncology.com/for-oncologists/patient-education/","url":"https://www.certisoncology.com/for-oncologists/patient-education/","name":"Functional Oncology Testing | Personalized Cancer Medicine","isPartOf":{"@id":"https://www.certisoncology.com/#website"},"datePublished":"2020-09-25T23:20:26+00:00","dateModified":"2024-03-28T23:40:35+00:00","description":"Functional oncology brings greater precision to personalized cancer medicine. Learn about YourPDX® testing to help inform next-line cancer treatment strategies.","breadcrumb":{"@id":"https://www.certisoncology.com/for-oncologists/patient-education/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://www.certisoncology.com/for-oncologists/patient-education/"]}]},{"@type":"BreadcrumbList","@id":"https://www.certisoncology.com/for-oncologists/patient-education/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.certisoncology.com/"},{"@type":"ListItem","position":2,"name":"Oncologists","item":"https://www.certisoncology.com/for-oncologists/"},{"@type":"ListItem","position":3,"name":"Patient Education"}]},{"@type":"WebSite","@id":"https://www.certisoncology.com/#website","url":"https://www.certisoncology.com/","name":"Certis Oncology","description":"","publisher":{"@id":"https://www.certisoncology.com/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://www.certisoncology.com/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https://www.certisoncology.com/#organization","name":"Certis Oncology","url":"https://www.certisoncology.com/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https://www.certisoncology.com/#/schema/logo/image/","url":"https://www.certisoncology.com/wp-content/uploads/certis-color.svg","contentUrl":"https://www.certisoncology.com/wp-content/uploads/certis-color.svg","width":1,"height":1,"caption":"Certis Oncology"},"image":{"@id":"https://www.certisoncology.com/#/schema/logo/image/"},"sameAs":["https://www.facebook.com/CertisOncology/","https://x.com/CertisOncology","https://www.linkedin.com/company/certis-oncology","https://www.facebook.com/CertisOncology","https://www.instagram.com/certis_oncology","https://www.youtube.com/channel/UCeX4_jh3RlNKxQxZ89_utjg","https://www.certisoncology.com/for-drug-developers/cancer-model-database-request/"]}]}</script> <!-- / Yoast SEO Premium plugin. --> <style id='classic-theme-styles-inline-css' type='text/css'> /*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}:where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;}:where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel="https://api.w.org/" href="https://www.certisoncology.com/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://www.certisoncology.com/wp-json/wp/v2/pages/215" /><link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://www.certisoncology.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww.certisoncology.com%2Ffor-oncologists%2Fpatient-education%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://www.certisoncology.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww.certisoncology.com%2Ffor-oncologists%2Fpatient-education%2F&format=xml" /> </head> <body> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-K5GS2LR" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="app" post="215" :browser="browser" :style="style" v-cloak><!-- vue app --> <navigation :items="{"featured":{"image":{"ID":5534,"id":5534,"title":"CTA_KRAS-CertiScreen-824x424","filename":"CTA_KRAS-CertiScreen-824x424-1.jpg","filesize":49609,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1.jpg","link":"https:\/\/www.certisoncology.com\/observational-clinical-research-study-testing-kras-targeting-therapies\/cta_kras-certiscreen-824x424\/","alt":"","author":"6","description":"","caption":"","name":"cta_kras-certiscreen-824x424","status":"inherit","uploaded_to":5651,"date":"2023-08-24 19:54:06","modified":"2023-10-03 19:51:30","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":824,"height":424,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1-720x370.jpg","medium-width":300,"medium-height":154,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1-768x395.jpg","medium_large-width":768,"medium_large-height":395,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1.jpg","large-width":824,"large-height":424,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1.jpg","1536x1536-width":824,"1536x1536-height":424,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1.jpg","2048x2048-width":824,"2048x2048-height":424,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1-540x278.jpg","small-width":540,"small-height":278,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1-540x424.jpg","square-sm-width":540,"square-sm-height":424,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1-720x424.jpg","square-md-width":720,"square-md-height":424,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1-640x424.jpg","portrait-width":640,"portrait-height":424,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CTA_KRAS-CertiScreen-824x424-1.jpg","landscape-width":824,"landscape-height":424}},"title":"VALIDATE YOUR KRAS-TARGETING STRATEGY ","content":"<p>Combining Predictive AI + Advanced Cancer Models to Help Direct Oncology Drug Development and Clinic Research Studies.<\/p>\n","link":{"title":"Learn More","url":"https:\/\/www.certisoncology.com\/kras-targeted-oncology-drug-development\/","target":""}},"login":"https:\/\/oncointel.certisoncology.com","navigation":[{"ID":6826,"post_author":"2","post_date":"2024-04-09 20:02:43","post_date_gmt":"2024-02-15 16:53:06","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"6826","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:43","post_modified_gmt":"2024-04-09 20:02:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?p=6826","menu_order":1,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":6826,"menu_item_parent":"0","object_id":"5","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/","title":"Home","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5867,"post_author":"1","post_date":"2024-04-09 20:02:43","post_date_gmt":"2024-01-13 00:10:52","post_content":"","post_title":"Drug Developers","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"drug-developers","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:43","post_modified_gmt":"2024-04-09 20:02:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?p=5867","menu_order":2,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5867,"menu_item_parent":"0","object_id":"5867","object":"custom","type":"custom","type_label":"Custom Link","title":"Drug Developers","url":"#","target":"","attr_title":"","description":"","classes":[""],"xfn":"","children":[{"ID":5872,"post_author":"1","post_date":"2024-04-09 20:02:43","post_date_gmt":"2024-01-13 00:10:52","post_content":"","post_title":"CertisAI\u2122\ufe0f","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"certis-ai","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:43","post_modified_gmt":"2024-04-09 20:02:43","post_content_filtered":"","post_parent":28,"guid":"https:\/\/www.certisoncology.com\/?p=5872","menu_order":3,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5872,"menu_item_parent":"5867","object_id":"5060","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/predictive-oncology-intelligence\/","title":"CertisAI\u2122\ufe0f","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5930,"post_author":"2","post_date":"2024-04-09 20:02:43","post_date_gmt":"2024-01-13 17:36:22","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5930","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:43","post_modified_gmt":"2024-04-09 20:02:43","post_content_filtered":"","post_parent":28,"guid":"https:\/\/www.certisoncology.com\/?p=5930","menu_order":4,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5930,"menu_item_parent":"5867","object_id":"221","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/cancer-models-preclinical-studies\/","title":"Cancer Models","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5873,"post_author":"1","post_date":"2024-04-09 20:02:43","post_date_gmt":"2024-01-13 00:10:52","post_content":"","post_title":"Custom Models","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"custom-models","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:43","post_modified_gmt":"2024-04-09 20:02:43","post_content_filtered":"","post_parent":28,"guid":"https:\/\/www.certisoncology.com\/?p=5873","menu_order":5,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5873,"menu_item_parent":"5867","object_id":"137","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/custom-model-development\/","title":"Custom Models","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5932,"post_author":"2","post_date":"2024-04-09 20:02:43","post_date_gmt":"2024-01-13 17:36:22","post_content":"","post_title":"In Vitro\/Ex Vivo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"in-vitro-ex-vivo","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:43","post_modified_gmt":"2024-04-09 20:02:43","post_content_filtered":"","post_parent":28,"guid":"https:\/\/www.certisoncology.com\/?p=5932","menu_order":6,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5932,"menu_item_parent":"5867","object_id":"5912","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/in-vitro-ex-vivo-pharmacology\/","title":"In Vitro\/Ex Vivo","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5933,"post_author":"2","post_date":"2024-04-09 20:02:43","post_date_gmt":"2024-01-13 17:36:22","post_content":"","post_title":"In Vivo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"in-vivo","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:43","post_modified_gmt":"2024-04-09 20:02:43","post_content_filtered":"","post_parent":28,"guid":"https:\/\/www.certisoncology.com\/?p=5933","menu_order":7,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5933,"menu_item_parent":"5867","object_id":"5914","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/in-vivo-pharmacology\/","title":"In Vivo","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5934,"post_author":"2","post_date":"2024-04-09 20:02:43","post_date_gmt":"2024-01-13 17:36:22","post_content":"","post_title":"Imaging\/Endpoints","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"imaging-endpoint","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:43","post_modified_gmt":"2024-04-09 20:02:43","post_content_filtered":"","post_parent":28,"guid":"https:\/\/www.certisoncology.com\/?p=5934","menu_order":8,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5934,"menu_item_parent":"5867","object_id":"5916","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/","title":"Imaging\/Endpoints","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5935,"post_author":"2","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 17:36:22","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5935","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":28,"guid":"https:\/\/www.certisoncology.com\/?p=5935","menu_order":9,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5935,"menu_item_parent":"5867","object_id":"5918","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/immuno-oncology\/","title":"Immuno-Oncology","target":"","attr_title":"","description":"","classes":[""],"xfn":""}]},{"ID":5868,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":"","post_title":"Oncologists","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"oncologists","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?p=5868","menu_order":10,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5868,"menu_item_parent":"0","object_id":"5868","object":"custom","type":"custom","type_label":"Custom Link","title":"Oncologists","url":"#","target":"","attr_title":"","description":"","classes":[""],"xfn":"","children":[{"ID":5937,"post_author":"2","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 17:42:17","post_content":"","post_title":"Order YourPDX<sup>\u00ae<\/sup>","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5937","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":389,"guid":"https:\/\/www.certisoncology.com\/?p=5937","menu_order":11,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5937,"menu_item_parent":"5868","object_id":"26","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-oncologists\/order-yourpdx\/","title":"Order YourPDX<sup>\u00ae<\/sup>","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5938,"post_author":"2","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 17:42:17","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5938","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":389,"guid":"https:\/\/www.certisoncology.com\/?p=5938","menu_order":12,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5938,"menu_item_parent":"5868","object_id":"5923","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-oncologists\/clinical-research\/","title":"Clinical Research","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5876,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5876","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":389,"guid":"https:\/\/www.certisoncology.com\/?p=5876","menu_order":13,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5876,"menu_item_parent":"5868","object_id":"215","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-oncologists\/patient-education\/","title":"Patient Education","target":"","attr_title":"","description":"","classes":[""],"xfn":""}]},{"ID":5869,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":"","post_title":"About","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"about","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?p=5869","menu_order":14,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5869,"menu_item_parent":"0","object_id":"5869","object":"custom","type":"custom","type_label":"Custom Link","title":"About","url":"#","target":"","attr_title":"","description":"","classes":[""],"xfn":"","children":[{"ID":5882,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5882","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":120,"guid":"https:\/\/www.certisoncology.com\/?p=5882","menu_order":15,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5882,"menu_item_parent":"5869","object_id":"124","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/about-us\/mission-vision-values\/","title":"Mission, Vision & Values","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5883,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"team","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":120,"guid":"https:\/\/www.certisoncology.com\/?p=5883","menu_order":16,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5883,"menu_item_parent":"5869","object_id":"126","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/about-us\/our-team\/","title":"Team","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5884,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5884","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":120,"guid":"https:\/\/www.certisoncology.com\/?p=5884","menu_order":17,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5884,"menu_item_parent":"5869","object_id":"4361","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/about-us\/our-story\/","title":"Our Story","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5885,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5885","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":120,"guid":"https:\/\/www.certisoncology.com\/?p=5885","menu_order":18,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5885,"menu_item_parent":"5869","object_id":"19","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/about-us\/careers\/","title":"Careers","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":7286,"post_author":"6","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-03-25 15:53:53","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"7286","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":120,"guid":"https:\/\/www.certisoncology.com\/7286\/","menu_order":19,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":7286,"menu_item_parent":"5869","object_id":"149","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/about-us\/news\/","title":"Company News","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5939,"post_author":"2","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 17:42:17","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5939","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?p=5939","menu_order":20,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5939,"menu_item_parent":"5869","object_id":"364","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/contact-us\/","title":"Contact Us","target":"","attr_title":"","description":"","classes":[""],"xfn":""}]},{"ID":5870,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":"","post_title":"Resource Library","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"resource-library","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?p=5870","menu_order":21,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5870,"menu_item_parent":"0","object_id":"5870","object":"custom","type":"custom","type_label":"Custom Link","title":"Resource Library","url":"#","target":"","attr_title":"","description":"","classes":[""],"xfn":"","children":[{"ID":5878,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5878","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":141,"guid":"https:\/\/www.certisoncology.com\/?p=5878","menu_order":22,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5878,"menu_item_parent":"5870","object_id":"143","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/resources\/cancer-market-facts\/","title":"Cancer Facts","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5879,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5879","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":141,"guid":"https:\/\/www.certisoncology.com\/?p=5879","menu_order":23,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5879,"menu_item_parent":"5870","object_id":"145","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/resources\/clinical-results\/","title":"Clinical Results","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5880,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5880","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":141,"guid":"https:\/\/www.certisoncology.com\/?p=5880","menu_order":24,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5880,"menu_item_parent":"5870","object_id":"147","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/resources\/supporting-research\/","title":"Supporting Research","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":7243,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-02-29 01:36:09","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"7243","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":141,"guid":"https:\/\/www.certisoncology.com\/?p=7243","menu_order":25,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":7243,"menu_item_parent":"5870","object_id":"7237","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/resources\/media\/","title":"Media","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":7296,"post_author":"6","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-03-25 20:25:22","post_content":"","post_title":"White Papers","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"white-papers","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?p=7296","menu_order":26,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":7296,"menu_item_parent":"5870","object_id":"7296","object":"custom","type":"custom","type_label":"Custom Link","title":"White Papers","url":"https:\/\/whitepapers.certisoncology.com\/","target":"","attr_title":"","description":"","classes":[""],"xfn":""}]},{"ID":5871,"post_author":"1","post_date":"2024-04-09 20:02:44","post_date_gmt":"2024-01-13 00:10:52","post_content":"","post_title":"Contact","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"contact","to_ping":"","pinged":"","post_modified":"2024-04-09 20:02:44","post_modified_gmt":"2024-04-09 20:02:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?p=5871","menu_order":27,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5871,"menu_item_parent":"0","object_id":"364","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/contact-us\/","title":"Contact","target":"","attr_title":"","description":"","classes":[""],"xfn":""}]}"></navigation> <div class="page"> <component-5f6e4af53220e :arr="{"default":false,"group":{"image":{"ID":1929,"id":1929,"title":"certis-hero-default","filename":"certis-hero-default.jpg","filesize":66686,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default.jpg","link":"https:\/\/www.certisoncology.com\/for-oncologists\/order-yourpdx\/certis-hero-default\/","alt":"","author":"1","description":"","caption":"","name":"certis-hero-default","status":"inherit","uploaded_to":26,"date":"2020-11-23 18:46:07","modified":"2020-11-25 19:58:19","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":1280,"height":320,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-720x180.jpg","medium-width":300,"medium-height":75,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-768x192.jpg","medium_large-width":768,"medium_large-height":192,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-960x240.jpg","large-width":960,"large-height":240,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default.jpg","1536x1536-width":1280,"1536x1536-height":320,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default.jpg","2048x2048-width":1280,"2048x2048-height":320,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-540x135.jpg","small-width":540,"small-height":135,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-540x320.jpg","square-sm-width":540,"square-sm-height":320,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-720x320.jpg","square-md-width":720,"square-md-height":320,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-640x320.jpg","portrait-width":640,"portrait-height":320,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/certis-hero-default-960x320.jpg","landscape-width":960,"landscape-height":320}},"text-overlay":{"ID":400,"id":400,"title":"hero-headline_certainty-saves-lives","filename":"hero-headline_certainty-saves-lives.svg","filesize":4262,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","link":"https:\/\/www.certisoncology.com\/certis-oncology-home\/hero-headline_certainty-saves-lives\/","alt":"Hero Tagline","author":"1","description":"","caption":"","name":"hero-headline_certainty-saves-lives","status":"inherit","uploaded_to":5,"date":"2020-10-02 16:31:37","modified":"2020-10-09 18:05:15","menu_order":0,"mime_type":"image\/svg+xml","type":"image","subtype":"svg+xml","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":0,"height":0,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","thumbnail-width":1,"thumbnail-height":1,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","medium-width":1,"medium-height":1,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","medium_large-width":1,"medium_large-height":1,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","large-width":1,"large-height":1,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","1536x1536-width":1,"1536x1536-height":1,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","2048x2048-width":1,"2048x2048-height":1,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","small-width":1,"small-height":1,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","square-sm-width":1,"square-sm-height":1,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","square-md-width":1,"square-md-height":1,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","portrait-width":1,"portrait-height":1,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/hero-headline_certainty-saves-lives.svg","landscape-width":1,"landscape-height":1}}}}"></component-5f6e4af53220e><component-5f7ce5112adb2 :singular="""" :arr="[{"ID":5947,"post_author":"2","post_date":"2024-02-29 20:25:24","post_date_gmt":"2024-01-13 18:03:33","post_content":"","post_title":"Order YourPDX<sup>\u00ae<\/sup>","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5947","to_ping":"","pinged":"","post_modified":"2024-02-29 20:25:24","post_modified_gmt":"2024-02-29 20:25:24","post_content_filtered":"","post_parent":389,"guid":"https:\/\/www.certisoncology.com\/?p=5947","menu_order":1,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5947,"menu_item_parent":"0","object_id":"26","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-oncologists\/order-yourpdx\/","title":"Order YourPDX<sup>\u00ae<\/sup>","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5948,"post_author":"2","post_date":"2024-02-29 20:25:24","post_date_gmt":"2024-01-13 18:03:33","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5948","to_ping":"","pinged":"","post_modified":"2024-02-29 20:25:24","post_modified_gmt":"2024-02-29 20:25:24","post_content_filtered":"","post_parent":389,"guid":"https:\/\/www.certisoncology.com\/?p=5948","menu_order":2,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5948,"menu_item_parent":"0","object_id":"5923","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-oncologists\/clinical-research\/","title":"Clinical Research","target":"","attr_title":"","description":"","classes":[""],"xfn":""},{"ID":5949,"post_author":"2","post_date":"2024-02-29 20:25:24","post_date_gmt":"2024-01-13 18:03:33","post_content":" ","post_title":"","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"5949","to_ping":"","pinged":"","post_modified":"2024-02-29 20:25:24","post_modified_gmt":"2024-02-29 20:25:24","post_content_filtered":"","post_parent":389,"guid":"https:\/\/www.certisoncology.com\/?p=5949","menu_order":3,"post_type":"nav_menu_item","post_mime_type":"","comment_count":"0","filter":"raw","db_id":5949,"menu_item_parent":"0","object_id":"215","object":"page","type":"post_type","type_label":"Page","url":"https:\/\/www.certisoncology.com\/for-oncologists\/patient-education\/","title":"Patient Education","target":"","attr_title":"","description":"","classes":[""],"xfn":""}]"></component-5f7ce5112adb2> <component-5f7cbffb57673 :arr="{"content":[{"headline":" ","entry":"<h1>THE POWER OF FUNCTIONAL PRECISION ONCOLOGY<\/h1>\n<p>The goal of precision oncology is to match an individual to the optimal therapy for their unique form of cancer, but clinical outcomes have lagged significantly behind its potential. Many people associate precision oncology (also known as personalized cancer medicine) with genetic testing. Genomic tumor profiling has advanced our understanding of cancer in recent years and brought about a whole new generation of targeted anticancer therapeutics. Beyond genomic profiling \u2014 which provides directional information about what might work for an individual \u2014 there are new functional oncology testing options that can help inform personalized cancer medicine.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":6720,"id":6720,"title":"Logo_YourPDX-with-icon-optimized","filename":"Logo_YourPDX-with-icon-optimized-e1708635289936.png","filesize":8139,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","link":"https:\/\/www.certisoncology.com\/for-oncologists\/order-yourpdx\/logo_yourpdx-with-icon-optimized\/","alt":"","author":"6","description":"","caption":"","name":"logo_yourpdx-with-icon-optimized","status":"inherit","uploaded_to":26,"date":"2024-02-12 23:12:06","modified":"2024-02-12 23:12:06","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":445,"height":344,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","medium-width":300,"medium-height":232,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","medium_large-width":445,"medium_large-height":344,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","large-width":445,"large-height":344,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","1536x1536-width":445,"1536x1536-height":344,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","2048x2048-width":445,"2048x2048-height":344,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","small-width":445,"small-height":344,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","square-sm-width":445,"square-sm-height":344,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","square-md-width":445,"square-md-height":344,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","portrait-width":445,"portrait-height":344,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_YourPDX-with-icon-optimized-e1708635289936.png","landscape-width":445,"landscape-height":344}},"href":"","title":"Beyond Genomics","description":"<p>In personalized cancer care, the definition of precision oncology has evolved beyond tumor genomics to include functional testing options. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e44ceb3c3d :arr="{"headline":"","content":"<blockquote>\n<p class=\"x_MsoNormal\">To know that I presently have a drug that is impacting the tumor and potentially four more in reserve is a game changer. I cannot tell you the impact this has had on my family and me. The pioneering work that Certis is doing has hugely impacted my life, knowing that I have a chance to beat back the cancer.”<\/p>\n<\/blockquote>\n<p><strong>Jeff Dinken<br \/>\n<\/strong><\/p>\n","featured":{"image":false,"image-href":"","headline":"","description":"","cta":""}}"></component-5f6e44ceb3c3d><component-5f6e4355bed24 :arr="{"content":"<h1>Four Important Things to Know About Functional Precision Oncology<\/h1>\n","callout":{"headline":" ","content":"","image":false},"layout":{"background":"gray","style":"default","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f7cbffb57673 :arr="{"content":[{"headline":" ","entry":"<h2>1. Functional Precision Oncology Can Capture Cancer\u2019s Complexities<\/h2>\n<p>Cancers are complex, dynamic and adaptive,<span class=\"tooltip\"><sup id=\"6662\">1<\/sup><\/span> and a tumor\u2019s genetic makeup can change over time. Genetic testing provides a static snapshot of genetic mutations and other aberrations within a tumor fragment, which can provide directional information about what targeted therapies might be effective for that individual. But contrary to popular belief, genetic testing alone cannot provide a complete answer; in fact, treatment guided solely by tumor genetics has a 95%+ outcome failure rate.<span class=\"tooltip\"><sup id=\"3996\">2<\/sup><\/span> Functional testing, on the other hand, is performed in a living system; it can capture the complexities of tumor tissue and biological interactions that take place in the tumor microenvironment<span class=\"tooltip\"><sup id=\"3996\">2<\/sup><\/span><span class=\"tooltip\"><sup id=\"6663\">3<\/sup><\/span> (i.e., the ecosystem that surrounds a tumor inside the body, which includes the immune cells, the extracellular matrix, blood vessels and other cells, like fibroblasts) . Functional assays are used to test the effectiveness of anti-cancer therapies directly and can be highly predictive of human drug response.<span class=\"tooltip\"><sup id=\"6662\">1<\/sup><\/span><span class=\"tooltip\"><sup id=\"3996\">2<\/sup><\/span><span class=\"tooltip\"><sup id=\"6663\">3<\/sup><\/span><\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":6368,"id":6368,"title":"Detailed-Tumor_lrg-optimized","filename":"Detailed-Tumor_lrg-optimized-e1708549685898.webp","filesize":139712,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898.webp","link":"https:\/\/www.certisoncology.com\/for-oncologists\/patient-education\/detailed-tumor_lrg-optimized\/","alt":"","author":"6","description":"","caption":"","name":"detailed-tumor_lrg-optimized","status":"inherit","uploaded_to":215,"date":"2024-01-31 23:37:17","modified":"2024-01-31 23:37:17","menu_order":0,"mime_type":"image\/webp","type":"image","subtype":"webp","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":1560,"height":1427,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-150x150.webp","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-720x659.webp","medium-width":300,"medium-height":275,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-768x703.webp","medium_large-width":768,"medium_large-height":703,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-960x878.webp","large-width":960,"large-height":878,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-1536x1405.webp","1536x1536-width":1536,"1536x1536-height":1405,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898.webp","2048x2048-width":1560,"2048x2048-height":1427,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-540x494.webp","small-width":540,"small-height":494,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-540x540.webp","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-720x720.webp","square-md-width":720,"square-md-height":720,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-640x920.webp","portrait-width":640,"portrait-height":920,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Detailed-Tumor_lrg-optimized-e1708549685898-960x640.webp","landscape-width":960,"landscape-height":640}},"href":"","title":"The Complex Tumor Microenvironment","description":"<p>Think of the tumor as a house, and the microenvironment as its local neighborhood. A tumor and its microenvironment constantly interact and influence each other.<span class=\"tooltip\"><sup id=\"3996\">2<\/sup><\/span><span class=\"tooltip\"><sup id=\"6663\">3<\/sup><\/span><\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":" ","entry":"<h2>2. <em>In Vitro<\/em> Screening is One Functional Approach to Precision Oncology<\/h2>\n<p>One type of functional test is what scientists call an <em>in vitro<\/em> screen, where cancer cells are extracted from a biopsied human tumor, grown in a petri dish or glass vial (i.e., artificial environment) in the laboratory, then dosed with anti-cancer therapies to see if the human cancer cells survive.<span class=\"tooltip\"><sup id=\"6664\">4<\/sup><\/span> With <em>in vitro<\/em> screens cancer cells are bathed in a drug for a predefined period in either a glass vial or petri dish, which is not physiologically equivalent to that of a human body. Research shows these in-lab tests have high false positive rates,<span class=\"tooltip\"><sup id=\"6663\">3<\/sup><\/span>\u00a0meaning they are very good at identifying drugs that will not work for an individual, so can be good at ruling out ineffective options.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":7116,"id":7116,"title":"in vitro_beaker","filename":"in-vitro_beaker.png","filesize":57097,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","link":"https:\/\/www.certisoncology.com\/for-oncologists\/patient-education\/in-vitro_beaker\/","alt":"in vitro beaker","author":"6","description":"in vitro screening is one type of functional approach to precision oncology","caption":"In vitro screening","name":"in-vitro_beaker","status":"inherit","uploaded_to":215,"date":"2024-02-23 18:39:05","modified":"2024-02-23 18:39:37","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":228,"height":351,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","medium-width":195,"medium-height":300,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","medium_large-width":228,"medium_large-height":351,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","large-width":228,"large-height":351,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","1536x1536-width":228,"1536x1536-height":351,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","2048x2048-width":228,"2048x2048-height":351,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","small-width":228,"small-height":351,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","square-sm-width":228,"square-sm-height":351,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","square-md-width":228,"square-md-height":351,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","portrait-width":228,"portrait-height":351,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/in-vitro_beaker.png","landscape-width":228,"landscape-height":351}},"href":"","title":"Personalized Functional Testing","description":"<p>Functional testing involves directly exposing live cancer cells from a person's tumor with various potential treatments to provide immediately translatable, personalized information that can guide therapy.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":" ","entry":"<h2>3. Personalized In-Life Testing is an Advanced Functional Approach<\/h2>\n<p>Personalized in-life testing (or what scientists call an <em>in vivo<\/em> pharmacology study) is an advanced and clinically relevant form of functional precision oncology.<span class=\"tooltip\"><sup id=\"3996\">2<\/sup><\/span><span class=\"tooltip\"><sup id=\"6663\">3<\/sup><\/span> In cancer research, the gold standard for <em>in vivo<\/em> functional testing is patient-derived xenografts (PDX)<span class=\"tooltip\"><sup id=\"3773\">5<\/sup><\/span> \u2014 mouse avatars of a person\u2019s cancer developed by engrafting fragments of human tumor tissue into animals.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":6291,"id":6291,"title":"YourPDXmouse-2-optimized","filename":"YourPDXmouse-2-optimized-e1708635219459.webp","filesize":10034,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459.webp","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/immuno-oncology\/yourpdxmouse-2-optimized-2\/","alt":"YourPDXmouse-2","author":"6","description":"YourPDXmouse-2","caption":"YourPDXmouse-2","name":"yourpdxmouse-2-optimized-2","status":"inherit","uploaded_to":5918,"date":"2024-01-31 17:50:48","modified":"2024-01-31 17:50:59","menu_order":0,"mime_type":"image\/webp","type":"image","subtype":"webp","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":1280,"height":849,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-150x150.webp","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-720x478.webp","medium-width":300,"medium-height":199,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-768x509.webp","medium_large-width":768,"medium_large-height":509,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-960x637.webp","large-width":960,"large-height":637,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459.webp","1536x1536-width":1280,"1536x1536-height":849,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459.webp","2048x2048-width":1280,"2048x2048-height":849,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-540x358.webp","small-width":540,"small-height":358,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-540x540.webp","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-720x720.webp","square-md-width":720,"square-md-height":720,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-640x849.webp","portrait-width":640,"portrait-height":849,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDXmouse-2-optimized-e1708635219459-960x640.webp","landscape-width":960,"landscape-height":640}},"href":"","title":" Personalized Mouse Avatars ","description":"<p>Research shows that personalized mouse avatars are concordant with human cancer,<span class=\"tooltip\"><sup id=\"6668\">6<\/sup><\/span> may accurately replicate clinical outcomes and can be used as a translational platform to evaluate next-line treatment strategies.<span class=\"tooltip\"><sup id=\"3624\">7<\/sup><\/span> <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":" ","entry":"<h2>4. YourPDX Functional Precision Oncology<sup>\u00ae<\/sup> Can Help Inform Next-Line Treatment Strategies<\/h2>\n<p>At Certis<sup>\u00ae<\/sup>, we use personalized patient-derived xenograft orthotopic models of an individual\u2019s cancer for testing. Orthotopic PDX models are different from other types of PDX models. They are developed by engrafting live tumor tissue in the anatomically correct place in mice. These mouse models serve as personalized mouse avatars of an individual\u2019s cancer. They allow us to simultaneously test multiple drugs or drug combinations and observe the relative effectiveness of the tested therapies in the mice. Compared to less advanced models, orthotopic PDX models have been shown to more closely mimic the tumor microenvironment, metastatic behavior and drug response observed in the clinic.<span class=\"tooltip\"><sup id=\"3769\">8<\/sup><\/span><span class=\"tooltip\"><sup id=\"3768\">9<\/sup><\/span><\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":7066,"id":7066,"title":"patient-education-tumor-model-chart","filename":"patient-education-tumor-model-chart.png","filesize":35034,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","link":"https:\/\/www.certisoncology.com\/for-oncologists\/patient-education\/patient-education-tumor-model-chart\/","alt":"","author":"6","description":"","caption":"","name":"patient-education-tumor-model-chart","status":"inherit","uploaded_to":215,"date":"2024-02-22 23:12:36","modified":"2024-02-22 23:12:36","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":425,"height":361,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","medium-width":300,"medium-height":255,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","medium_large-width":425,"medium_large-height":361,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","large-width":425,"large-height":361,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","1536x1536-width":425,"1536x1536-height":361,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","2048x2048-width":425,"2048x2048-height":361,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","small-width":425,"small-height":361,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","square-sm-width":425,"square-sm-height":361,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","square-md-width":425,"square-md-height":361,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","portrait-width":425,"portrait-height":361,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/patient-education-tumor-model-chart.png","landscape-width":425,"landscape-height":361}},"href":"","title":" Advanced Cancer Models ","description":"<p>Certis scientists will randomize fully tumored avatars into study arms of five mice each, and each cohort will receive one of the chosen treatment options over a 28-day dosing period. We will use MRI and quantitative three-dimensional tumor volume measurement (TVM) to record changes in tumor size in each of the mice.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e4355bed24 :arr="{"content":"<h2>What’s Next? Be Armed with Therapeutic Options<\/h2>\n<p>YourPDX<sup>\u00ae<\/sup> testing takes an average of 4-6 months to complete and is not intended to inform first-line treatment decisions. At the same time an individual undergoes prescribed therapy, Certis will develop personalized mouse avatars. Once the mice are fully tumored, these mice are simultaneously tested with a variety of treatment options, indicated by a patient’s physician; genomics and AI-enabled predictions may also help inform therapies that are tested. We then evaluate and assess the performance of these tested therapies in orthotopic mouse models to help inform next-line treatment strategies.<span class=\"tooltip\"><sup id=\"3996\">2<\/sup><\/span><span class=\"tooltip\"><sup id=\"6663\">3<\/sup><\/span><span class=\"tooltip\"><sup id=\"3624\">7<\/sup><\/span><span class=\"tooltip\"><sup id=\"3769\">8<\/sup><\/span><span class=\"tooltip\"><sup id=\"3768\">9<\/sup><\/span> Should a person not respond to first-line treatment, develop resistance to a previously effective therapy, or experience recurrence after successful treatment, the treating oncologist can be armed with alternative therapeutic options for that individual with cancer.<\/p>\n<p><a href=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/161-YourPDX-Tissue-Donation-Testing-Consent-HIPAA-Acknowledgement4156a5fda78694cf1308f30e7a902fdb335eccb4c577463159d9dc90580cc257.pdf\" target=\"_blank\" rel=\"noopener\">Download Consent Pack<\/a><\/p>\n<div style=\"text-align: center;\"><img decoding=\"async\" src=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/TreatmentTimeline-GrayBG-optimized-e1708543042917.webp\" alt=\"\" width=\"80%\" \/><\/div>\n<h3>Representative Cancer Treatment Journey<\/h3>\n<p>This sample timeline of an individual\u2019s cancer treatment journey illustrates a possible treatment path, as well as possible key outcomes.<\/p>\n","callout":{"headline":"","content":"","image":false},"layout":{"background":"cells","style":"default","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f6e40ba1bdc4 :arr="{"title":" ","content":"","headline":"YourPDX Testing: Answers to Frequently Asked Questions","items":[{"ID":6396,"post_author":"6","post_date":"2024-01-31 23:58:26","post_date_gmt":"2024-01-31 23:58:26","post_content":"\n<p>YourPDX is a functional oncology drug sensitivity test that is performed in a living system or <em>in vivo<\/em>, which is a Latin term for <em>within the living<\/em>. It refers to tests, experiments, and procedures that researchers perform in, or on, a whole living organism. The term <em>pharmacology<\/em> is a branch of science that deals with the testing of drugs and evaluating their actions on living systems. The <em>in vivo <\/em>pharmacology or functional drug sensitivity testing we perform at Certis involves closely replicating an individual’s unique form of cancer in very specialized, immunocompromised research mice, then testing tumor response to multiple therapeutic options simultaneously in these personalized mouse avatars. The data we gather can help inform next-line treatment strategies for an individual’s unique form of cancer.<\/p>\n","post_title":"What is YourPDX testing?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-is-yourpdx-testing","to_ping":"","pinged":"","post_modified":"2024-02-17 00:10:16","post_modified_gmt":"2024-02-17 00:10:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6396","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6397,"post_author":"6","post_date":"2024-01-31 23:59:48","post_date_gmt":"2024-01-31 23:59:48","post_content":"\n<p>Our functional oncology testing consists of two phases.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Phase One: Initiation. The purpose of the Initiation phase is to establish human tumor tissue in immunocompromised mice, and to expand (grow) adequate tissue volume to support Phase Two: Pharmacology. Human tumor tissue will be implanted in up to five (5) immunocompromised mice, usually in multiple anatomic locations to increase chances of successful establishment. This first cohort (group) of mice is referred to as the \u201cF1 generation.\u201d In some cases, particularly in those involving slow-growing tumors, a second \u201cpassage\u201d may be required to create sufficient tissue volume. This involves harvesting tumor tissue from F1 generation mice and engrafting it into a second cohort of mice (the F2 generation).<\/li>\n\n\n\n<li>Phase Two: Pharmacology. If the Initiation phase is successful, Certis can proceed to the second phase, Pharmacology testing. This involves developing a sufficient number of orthotopically engrafted mice to support the agreed-upon test agents, then dosing patient-derived xenograft orthotopic models with the selected therapies to simultaneously evaluate tumor response in each mouse.\u202f<\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/YourPDX-Detailed-Patient-Flyer_R10-WEB_FINAL.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download the fact sheet<\/a> for more step-by-step information on YourPDX testing.<\/p>\n","post_title":"Describe each phase of the YourPDX testing process.","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"describe-each-phase-of-the-yourpdx-testing-process","to_ping":"","pinged":"","post_modified":"2024-01-31 23:59:49","post_modified_gmt":"2024-01-31 23:59:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6397","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6398,"post_author":"6","post_date":"2024-02-01 00:00:33","post_date_gmt":"2024-02-01 00:00:33","post_content":"\n<p>Five mouse models are enrolled in\u202feach\u202farm. Every YourPDX test is comprised of one control arm in which mice are untreated, plus one additional arm for each drug or combination therapy to be tested. The treating oncologist will recommend the number and types of drugs or combination therapies to be tested. Certis Scientific and Medical Advisory Board members can assist with these recommendations.<\/p>\n","post_title":"How many mouse models will be used in the Pharmacology phase of YourPDX testing?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-many-mouse-models-will-be-used-in-my-pharmacology-phase","to_ping":"","pinged":"","post_modified":"2024-02-16 23:42:20","post_modified_gmt":"2024-02-16 23:42:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6398","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6399,"post_author":"6","post_date":"2024-02-01 00:01:21","post_date_gmt":"2024-02-01 00:01:21","post_content":"\n<p>Our functional oncology test is generally a good fit for any US adult (18+ years or older) diagnosed with a solid tumor cancer determined by their oncologist to be regional, distant or have metastatic potential \u2014 typically late stage 2 through 3, and who are well enough to undergo a oncologist-ordered biopsy or resection surgery. All too often, individuals with cancer come to us very late in their disease when they have treatment fatigue and are out of standard of care options. Imagine if every individual diagnosed with cancer knew in advance their next-line treatment options.<\/p>\n\n\n\n<p><em>Note: Tissue from tumors treated with radiation within 10 weeks prior to biopsy or resection surgery cannot be accepted.<\/em><\/p>\n","post_title":"How does an individual with cancer assess whether they are a good candidate for YourPDX testing?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-do-i-assess-whether-im-a-good-candidate-for-yourpdx-testing","to_ping":"","pinged":"","post_modified":"2024-02-16 23:34:53","post_modified_gmt":"2024-02-16 23:34:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6399","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6400,"post_author":"6","post_date":"2024-02-01 00:01:56","post_date_gmt":"2024-02-01 00:01:56","post_content":"\n<p>In most cases, yes, Certis can perform YourPDX testing if an individual has been recently treated, or undergoing treatment for cancer. In fact, most individuals we serve are being treated with a current standard of care therapy(s) while we develop their personalized mouse avatars for functional oncology drug sensitivity testing. An exception is if you recently have had radiation treatments at the site from which a fresh tissue biopsy needs to be taken (within 10 weeks). Radiated tumor tissue will rarely engraft in mice.<sup>1<\/sup><\/p>\n\n\n\n<p><strong>References: 1<\/strong> Russell TA, Eckardt MA, Murakami T, Elliott IA, Kawaguchi K, Kiyuna T, Igarashi K, Li Y, Crompton JG, Graham DS, Dry SM, Bernthal N, Yanagawa J, Kalbasi A, Federman N, Chmielowski B, Singh AS, Hoffman RM, Eilber FC. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3245\" target=\"_blank\" rel=\"noreferrer noopener\">Clinical Factors That Affect the Establishment of Soft Tissue Sarcoma Patient-Derived Orthotopic Xenografts: A University of California, Los Angeles, Sarcoma Program Prospective Clinical Trial<\/a>. <em>JCO Precis Oncol<\/em>. 2017;2017:10.<\/p>\n","post_title":"Can Certis perform YourPDX testing if I\u2019ve recently been treated, or I am currently undergoing treatment for cancer?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-certis-perform-yourpdx-testing-if-ive-recently-been-treated-or-i-am-currently-undergoing-treatment-for-cancer","to_ping":"","pinged":"","post_modified":"2024-02-21 20:50:41","post_modified_gmt":"2024-02-21 20:50:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6400","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6401,"post_author":"6","post_date":"2024-02-01 00:02:27","post_date_gmt":"2024-02-01 00:02:27","post_content":"\n<p>Ideally, the individual with cancer and the treating oncologist will decide whether to pursue testing before the patient has undergo a resection surgery or biopsy, as our process begins with a fresh sample of tumor tissue. For scheduled procedures, Certis needs at least two days\u2019 advance notice so we can ship the tumor tissue sample collection kit to the surgical center.<\/p>\n","post_title":"When does an individual with cancer need to decide if they want to proceed with Certis YourPDX testing?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"when-do-i-need-to-decide-if-i-want-to-proceed-with-certis-yourpdx-testing","to_ping":"","pinged":"","post_modified":"2024-02-16 23:54:51","post_modified_gmt":"2024-02-16 23:54:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6401","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6402,"post_author":"6","post_date":"2024-02-01 00:03:14","post_date_gmt":"2024-02-01 00:03:14","post_content":"\n<p>Cryopreservation is a process that preserves tumor tissue by cooling the sample to very low temperatures. While it is scientifically possible to revive (or warm) cryopreserved tissue and develop PDX models from it, the success of that approach depends greatly on the method of cryopreservation, and the size (minimum one cubic centimeter) and condition of the tumor tissue sample. At Certis, we prefer to work with fresh tumor tissue (received and engrafted within 24 hours of biopsy or resection surgery) to maximize the likelihood of a successful study.<\/p>\n","post_title":"Can you perform YourPDX testing from cryopreserved tissue?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-you-perform-yourpdx-testing-from-cryopreserved-tissue","to_ping":"","pinged":"","post_modified":"2024-02-21 19:28:24","post_modified_gmt":"2024-02-21 19:28:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6402","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6403,"post_author":"6","post_date":"2024-02-01 00:03:45","post_date_gmt":"2024-02-01 00:03:45","post_content":"\n<p>Human donor tumor tissue from early-stage solid tumor cancers typically do not engraft well. That said, just knowing that YourPDX testing is an option from the start can help individuals with cancer and their treating oncologist make informed decisions about the use of tumor tissue upfront.\u202f<\/p>\n\n\n\n<p><em>Note: Biopsies can be invasive procedures, and oncologists will order them only when they are considered medically necessary and feasible. Consequently, tumor tissue is precious and limited. Carefully consider the best use of precious tumor tissue \u2014 it may be depleted for other types of effective precision oncology tests or required for participation in clinical trials down the line. However, some clinical trials do wave the biopsy requirement if genetic testing is already done.<\/em><\/p>\n","post_title":"Should individuals with cancer consider Certis YourPDX testing from the start?\u202f","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"should-i-consider-certis-yourpdx-testing-from-the-start","to_ping":"","pinged":"","post_modified":"2024-02-16 23:45:10","post_modified_gmt":"2024-02-16 23:45:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6403","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6340,"post_author":"6","post_date":"2024-01-31 22:19:56","post_date_gmt":"2024-01-31 22:19:56","post_content":"\n<p>Genetic testing is a complementary scientific tool that provides clues about which drugs might be effective against an individual’s unique form of cancer. This information can be helpful in making decisions about which drugs to test in mouse avatars, but it is not required to proceed with functional oncology drug sensitivity test. Genetic testing (NGS) involves the examination of an individual’s DNA to identify possible changes (mutations) in their genes. It can provide valuable insight into a cancer diagnosis, treatment and prevention, but it cannot inform individuals whether specific mutations are driving their cancer, and therefore, has limitations.<sup>1<\/sup><\/p>\n\n\n\n<p><strong>References: 1 <\/strong>Mayo Clinic, <a href=\"https:\/\/www.mayoclinic.org\/tests-procedures\/genetic-testing\/about\/pac-20384827\" target=\"_blank\" rel=\"noreferrer noopener\">Genetic Testing \u2014 Overview<\/a>. Mayo Foundation for Medical Education and Research (MFMER). 1998-2021. Accessed online on Aug. 24, 2021.<\/p>\n","post_title":"How does genetic testing compare to YourPDX testing?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-does-genetic-testing-compare-to-yourpdx-testing","to_ping":"","pinged":"","post_modified":"2024-02-17 00:07:32","post_modified_gmt":"2024-02-17 00:07:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6340","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6404,"post_author":"6","post_date":"2024-02-01 00:09:20","post_date_gmt":"2024-02-01 00:09:20","post_content":"\n<p><em>In vitro<\/em> testing is another complementary scientific tool that provides clues about which drugs might be effective against an individual’s unique form of cancer. This information can be helpful in making decisions about which drugs to test in an individual’s mouse avatars, but it is not required to proceed with YourPDX <em>in vivo<\/em> pharmacology testing.<\/p>\n\n\n\n<p><em>In vitro<\/em> is Latin for <em>in glass<\/em>. It describes medical procedures, tests, and experiments that researchers perform outside of a living organism. An <em>in vitro <\/em>study occurs in a controlled environment, such as a test tube or petri dish. <em>In vivo<\/em> is Latin for <em>within the living<\/em>. It refers to tests, experiments, and procedures that researchers perform in or on a whole living organism.<\/p>\n\n\n\n<p>In cancer research, traditional 2D <em>in vitro<\/em> tumor models are often used to examine characteristics of individual cancer cells. While this method can reduce complexity and cost, it can present significant treatment and prognostic challenges.<sup>1<\/sup><\/p>\n\n\n\n<p>Cancer cells within a tumor are highly heterogeneous (dissimilar) and are unable to replicate the complicated environment and mechanisms of a solid tumor and its growth.<sup>2<\/sup> Dissociated cancer cells are more vulnerable to anticancer agents\u2014which may lead to false positives.<\/p>\n\n\n\n<p><strong>References: 1<\/strong> Elmore, LW et al. <a href=\"https:\/\/doi.org\/10.3322\/caac.21652\" target=\"_blank\" rel=\"noreferrer noopener\">Blueprint for cancer research: Critical gaps and opportunities<\/a>. <em>CA Cancer J Clin<\/em>. 2021. https:\/\/doi.org\/10.3322\/caac.21652. <strong>2<\/strong> Bartlett, R et al. <a href=\"https:\/\/doi.org\/10.1016\/j.tranon.2014.10.006\" target=\"_blank\" rel=\"noreferrer noopener\">Personalized In Vitro Cancer Modeling \u2014 Fantasy or Reality?<\/a>, <em>Transl. Oncology<\/em>, Vol. 7, Issue 6, 2014, pg. 657-664, ISSN 1936-5233, https:\/\/doi.org\/10.1016\/j.tranon.2014.10.006.<\/p>\n","post_title":"How does personalized in vitro testing compare with the type of functional oncology in vivo testing Certis performs?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-does-personalized-in-vitro-testing-compare-with-the-type-of-functional-oncology-in-vivo-testing-certis-performs","to_ping":"","pinged":"","post_modified":"2024-02-16 23:38:54","post_modified_gmt":"2024-02-16 23:38:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6404","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6406,"post_author":"6","post_date":"2024-02-01 00:10:08","post_date_gmt":"2024-02-01 00:10:08","post_content":"\n<p>It not possible to say exactly how long the YourPDX testing process takes because every cancer is different and tumors grow at different rates. The typical duration is six months from tumor biopsy\/resection surgery to delivery of final report to an individual’s treating oncologist. On average, Phase One: Initiation takes four to 12 weeks to determine whether the engraftment is successful, and another four to 12 weeks before the tumor grows large enough to begin Phase Two: Pharmacology.<\/p>\n","post_title":"How long will the YourPDX testing process take?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-long-will-the-yourpdx-testing-process-take","to_ping":"","pinged":"","post_modified":"2024-02-16 23:41:09","post_modified_gmt":"2024-02-16 23:41:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6406","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6407,"post_author":"6","post_date":"2024-02-01 00:10:34","post_date_gmt":"2024-02-01 00:10:34","post_content":"\n<p>Our functional oncology drug sensitivity test is generally not covered by insurance. Insurers usually base payment decisions on large datasets. While the utility of patient-derived xenograft orthotopic models is well documented in preclinical cancer research, the technology is not (yet) mainstream in clinical practice.<\/p>\n","post_title":"Is YourPDX testing covered by insurance?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"is-yourpdx-testing-covered-by-insurance","to_ping":"","pinged":"","post_modified":"2024-02-01 00:10:35","post_modified_gmt":"2024-02-01 00:10:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6407","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6408,"post_author":"6","post_date":"2024-02-01 00:11:42","post_date_gmt":"2024-02-01 00:11:42","post_content":"\n<p>Fees are dependent upon the number of treatment options tested. Certis will work directly with the YourPDX testing participant or other financially responsible person to put in place a Patient Services Agreement, which will detail fees. Standard fees are as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Phase One – Study Initiation: The standard fee is $10,000, which includes next-generation sequencing (NGS) on the primary tumor tissue. If engraftment is not successful and the Initiation Study fails, we cannot issue a refund.<\/li>\n\n\n\n<li>Phase Two – Pharmacology Study: Fees are based on the number of treatment options included in the study design.<\/li>\n<\/ul>\n\n\n\n<p>Each study requires one control arm (this is the group of untreated mice required to compare tumor response): $7,500. Each therapy or combination therapy to be tested represents one arm. For each study arm, we enroll five fully tumored mice to ensure reliable data. The fee is $7,500 per arm. A drug recovery fee may be assessed for test agents that cost over $250 per arm.<\/p>\n\n\n\n<p><strong>EXAMPLE:<\/strong> An individual elects to test four different treatment options.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Phase One: Initiation: $10,000<\/li>\n\n\n\n<li>Phase Two: Pharmacology With Four Tested Treatment Options: $7,500 x 4 ($30,000) + $7,500 (control arm) = $37,500<\/li>\n<\/ul>\n\n\n\n<p>Total: $47,500<\/p>\n","post_title":"How much does YourPDX testing cost?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-much-does-yourpdx-testing-cost","to_ping":"","pinged":"","post_modified":"2024-02-01 00:11:42","post_modified_gmt":"2024-02-01 00:11:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6408","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6409,"post_author":"6","post_date":"2024-02-01 00:12:28","post_date_gmt":"2024-02-01 00:12:28","post_content":"\n<p>Upon execution of a Patient Services Agreement, Certis will issue an invoice for the cost of Phase One: Initiation. Payment for this part of the process is due prior to shipment of the Certis tumor tissue sample collection kit. Once we confirm engraftment is successful, and an individual with cancer has decided the number of therapeutic options they wish to test in Phase Two: Pharmacology, a Certis Patient Services Manager will prepare an Amendment to the Patient Services Agreement for approval. This Amendment will detail the number of test arms and the cost of test agents. Payment for your Phase Two: Pharmacology is due before we can begin engrafting the number of patient-derived xenograft orthotopic models needed to support the functional oncology test.<\/p>\n","post_title":"When is payment for YourPDX testing due?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"when-is-payment-for-yourpdx-testing-due","to_ping":"","pinged":"","post_modified":"2024-02-17 00:05:00","post_modified_gmt":"2024-02-17 00:05:00","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6409","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6410,"post_author":"6","post_date":"2024-02-01 00:13:03","post_date_gmt":"2024-02-01 00:13:03","post_content":"\n<p>It\u2019s helpful to know upfront which therapies will be tested to avoid delays. It\u2019s important to makes these decision early with the treating oncologist, as procuring these test agents can take time. Certis will need to know how many test arms will be included to determine the number of patient-derived xenograft orthotopic model replicates to create. We enroll five fully tumored mouse avatars in each test arm, including the control arm. By way of example: if an individual chooses to test five different therapeutic options, that is a 6 test arms (5 plus 1 control); 30 fully tumored mouse avatars would be required to conduct the test. We generally engraft 25% more mice than are needed to ensure we have enough avatars when it comes time to begin testing.\u202f<\/p>\n","post_title":"Why is it important to plan Phase Two: Pharmacology early?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"why-is-it-important-to-plan-phase-two-pharmacology-early","to_ping":"","pinged":"","post_modified":"2024-02-17 00:01:02","post_modified_gmt":"2024-02-17 00:01:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6410","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6411,"post_author":"6","post_date":"2024-02-01 00:13:26","post_date_gmt":"2024-02-01 00:13:26","post_content":"\n<p>Decisions about how many and which therapies should be tested in personalized mouse avatars rest with the individual with cancer and the treating oncologist. Upon request, members of the Certis Medical Advisory Board can also collaborate with the individual and their treating oncologist to help identify therapeutic options to test in mouse avatars. Therapeutic options that are recommended for YourPDX testing could fall outside the standard of care and may include drugs that target specific mutations or other biomarkers, off-label and investigational therapies. A Certis Patient Care Manager will provide pricing based on specific needs.<\/p>\n","post_title":"Who determines what therapies should be tested?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"who-determines-what-therapies-should-be-tested","to_ping":"","pinged":"","post_modified":"2024-02-16 23:52:08","post_modified_gmt":"2024-02-16 23:52:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6411","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6412,"post_author":"6","post_date":"2024-02-01 00:14:07","post_date_gmt":"2024-02-01 00:14:07","post_content":"\n<p>Think of patient-derived xenograft (PDX) orthotopic models as personalized mouse avatars \u2014 close replicates of an individual’s unique form of cancer in immuno-compromised mice. To create a PDX orthotopic model, Certis scientists surgically implant fragments of expanded tumor tissue from first-generation mice into the location of origin\u2014the same anatomical location from which the original tumor came from in the individual’s body. For example, if the tumor biopsy came from the colon, we engraft tissue into the mouse avatars\u2019 colon. This is important because we know from years of research that the tumor microenvironment in which a tumor grows can greatly influence drug response, drug resistance and metastatic behavior.<\/p>\n","post_title":"What is special about patient-derived xenograft orthotopic models, and why does Certis use them for YourPDX testing?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-is-special-about-patient-derived-xenograft-orthotopic-models-and-why-does-certis-use-them-for-yourpdx-testing","to_ping":"","pinged":"","post_modified":"2024-02-16 23:59:23","post_modified_gmt":"2024-02-16 23:59:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6412","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6413,"post_author":"6","post_date":"2024-02-01 00:15:41","post_date_gmt":"2024-02-01 00:15:41","post_content":"\n<p>There are many technologies in the field of precision oncology (genomic profiling, <em>in vitro<\/em> testing,\u202f<em>in silico\u202f<\/em>modeling and others) that can give insight into which types of therapies might lead to a positive clinical response. In fact, these tools are complimentary to the functional oncology testing we do at Certis because they can help narrow down which therapies to test in an individual’s personalized mouse avatars, but they aren\u2019t a necessity for YourPDX testing. The patient-derived xenograft orthotopic models we use for functional oncology testing closely recapitulate (repeat) human tumor development, closely mimic the behavior of cancer in their human counterparts and have the potential to better reflect the range of mutations and genetic background present in human cancers.<sup>1<\/sup><\/p>\n\n\n\n<p><strong>References: 1<\/strong> Mattar M, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29515970\/\" target=\"_blank\" rel=\"noreferrer noopener\">Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models<\/a>. <em>Front Oncol<\/em>. 2018;8:19. Published 2018 Feb 19.<\/p>\n","post_title":"How does YourPDX testing compare to other types of precision oncology testing options?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-does-yourpdx-testing-compare-to-other-types-of-precision-oncology-testing-options","to_ping":"","pinged":"","post_modified":"2024-02-21 20:39:38","post_modified_gmt":"2024-02-21 20:39:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6413","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6414,"post_author":"6","post_date":"2024-02-01 00:16:09","post_date_gmt":"2024-02-01 00:16:09","post_content":"\n<p>Certis scientists carefully formulate test agents by scaling human treatment regimens into mouse-appropriate doses for the YourPDX test. Researchers have been studying drug response in mice for decades, so there is an abundance of peer-reviewed scientific literature to guide us when making murine-scale dosing decisions.<\/p>\n","post_title":"When it\u2019s time to dose the mice as part of the functional oncology test, how do Certis scientists know how much of the drug(s) to administer to mice?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"when-its-time-to-dose-the-mice-as-part-of-my-functional-oncology-test-how-do-certis-scientists-know-how-much-of-the-drugs-to-administer-to-the-mice","to_ping":"","pinged":"","post_modified":"2024-02-16 23:50:29","post_modified_gmt":"2024-02-16 23:50:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6414","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":2170,"post_author":"6","post_date":"2020-12-17 22:26:50","post_date_gmt":"2020-12-17 22:26:50","post_content":"\n<p>There is a large and growing body of scientific literature that shows patient-derived orthotopic\u202fmodels created from a human\u202fpatient\u2019s cancer tissue closely mirror drug response, resistance and recurrence that occurs in the human\u202fpatient.<sup>1<\/sup><\/p>\n\n\n<p><strong>1<\/strong> Mattar M, et al. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3779\" target=\"_blank\" rel=\"noopener\">Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models<\/a>. <em>Front Oncol<\/em>. 2018; 8(19).<\/p>","post_title":"If my mouse avatars respond to a particular therapy, how can an individual be sure that the same drug or combination of drugs will work on their cancer, too?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"if-my-mouse-avatars-respond-to-a-particular-therapy-can-i-be-sure-the-same-drug-or-combination-of-drugs-will-work-on-my-cancer-too","to_ping":"","pinged":"","post_modified":"2024-02-16 23:56:43","post_modified_gmt":"2024-02-16 23:56:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=2170","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6417,"post_author":"6","post_date":"2024-02-01 00:19:05","post_date_gmt":"2024-02-01 00:19:05","post_content":"\n<p>The final report will be sent to the treating oncologist and detail the testing protocol used, drugs or combination therapies tested and therapeutic response of each group of mouse cohorts over time, measured in terms of tumor volume. It will include actual MRI images of the mouse avatars\u2019 tumor sizes as well as detailed histology images of structural cellular changes observed during the functional oncology test. This information can help inform next-line treatment strategies for an individual\u2019s unique form of cancer.<\/p>\n","post_title":"When YourPDX testing is complete, what will the final report include?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"when-yourpdx-testing-is-complete-what-will-the-final-report-include","to_ping":"","pinged":"","post_modified":"2024-02-01 00:19:06","post_modified_gmt":"2024-02-01 00:19:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6417","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1791,"post_author":"6","post_date":"2020-11-19 22:00:59","post_date_gmt":"2020-11-19 22:00:59","post_content":"\n<p>Some individuals elect to have Certis perform an extended Recurrence and Resistance test to monitor their mouse avatars an additional four weeks after the functional oncology test is complete. No medication is administered during this time. By monitoring and measuring tumors post-test, we can often infer whether some therapeutic options lead to more lasting tumor response in the mouse avatars and are sometimes able to see signs of drug resistance and\/or predict future metastases in the mice.<\/p>\n","post_title":"Can the results from YourPDX testing help determine whether a cancer will return?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-is-a-drug-resistance-study","to_ping":"","pinged":"","post_modified":"2024-02-01 00:20:58","post_modified_gmt":"2024-02-01 00:20:58","post_content_filtered":"","post_parent":0,"guid":"http:\/\/certisoncology.com\/?post_type=type-faqs&p=1791","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"}],"cta":"","layout":{"background":"","background-offset":""}}"></component-5f6e40ba1bdc4><component-5f6e4355bed24 :arr="{"content":"<p>YOURPDX IS A FUNCTIONAL DRUG SENSITIVITY TEST THAT MEASURES THERAPEUTIC RESPONSE IN ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS. TEST RESULTS ARE NOT A REPLACEMENT FOR MEDICAL ADVICE. TREATMENT DECISIONS ARE THE RESPONSIBILITY OF PATIENTS AND THEIR PHYSICIANS. YOURPDX TESTING REQUIRES FRESH TUMOR TISSUE. IT IS ESSENTIAL TO CONTACT US PRIOR TO BIOPSY OR RESECTION SURGERY.<\/p>\n","callout":{"headline":"","content":"","image":false},"layout":{"background":"gray","style":"default","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f6e424bba9c9 :arr="{"headline":"Have a Question?","description":"","cta":{"title":"Contact Us","url":"https:\/\/www.certisoncology.com\/contact-us\/","target":""},"layout":{"background":"cells","style":"default","sticky":true}}"></component-5f6e424bba9c9> </div> <footer> <div class="container"> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="mb-4 mb-md-2 mb-lg-0 mr-sm-4"> <figure class="mb-3 mr-lg-6"> <img class="img-fluid d-block" src="/wp-content/themes/certis/images/certis-logo-lockup-white.svg"> </figure> <address> <div> <span class="street-address d-block">5626 Oberlin Drive, Suite 110</span> <span class="city state zip d-block mb-3">San Diego, CA 92121</span> </div> <div> <span class="phone d-block">Drug Development: 858-988-1033</span> <span class="phone d-block">Patients & Oncologists: 858-228-4110</span> <span class="phone d-block">Main: 858-952-1820</span> </div> </address> </div> <nav class="flex-grow-1"> <ul class="sections ml-0 ml-md-4"> <li> <h4 style="text-transform: uppercase;">Drug Developers</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/for-drug-developers/predictive-oncology-intelligence/">CertisAI™</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/cancer-models-preclinical-studies/">Cancer Models</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/custom-model-development/">Custom Model Development</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/in-vitro-ex-vivo-pharmacology/">In Vitro/Ex Vivo Pharmacology</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/in-vivo-pharmacology/">In Vivo Pharmacology</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/imaging-endpoint-analysis/">Imaging/Endpoint Analysis</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/immuno-oncology/">Immuno-Oncology</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">Oncologists</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/for-oncologists/order-yourpdx/">Order YourPDX<sup>®</sup></a></li> <li><a href="https://www.certisoncology.com/for-oncologists/clinical-research/">Clinical Research</a></li> <li><a href="https://www.certisoncology.com/for-oncologists/patient-education/">Patient Education</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">Resource Library</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/resources/cancer-market-facts/">Cancer Facts</a></li> <li><a href="https://www.certisoncology.com/resources/clinical-results/">Clinical Results</a></li> <li><a href="https://www.certisoncology.com/resources/supporting-research/">Supporting Research</a></li> <li><a href="https://www.certisoncology.com/resources/media/">Media</a></li> <li><a href="https://whitepapers.certisoncology.com/">White Papers</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">About</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/about-us/mission-vision-values/">Mission, Vision & Values</a></li> <li><a href="https://www.certisoncology.com/about-us/our-team/">Team</a></li> <li><a href="https://www.certisoncology.com/about-us/our-story/">Our Story</a></li> <li><a href="https://www.certisoncology.com/about-us/careers/">Careers</a></li> <li><a href="https://www.certisoncology.com/about-us/news/">Company News</a></li> <li><a href="https://www.certisoncology.com/contact-us/">Contact Us</a></li> <li><a href="https://oncointel.certisoncology.com/">Login</a></li> <li><a href="https://www.certisoncology.com/privacy-policy/">Privacy Policy</a></li> </ul> </li> </ul> </nav> </div> <div class="d-flex justify-content-between align-items-end mt-2"> <div class="social-media icons"> <ul> <li><a href="https://www.facebook.com/CertisOncology" target="_blank" class="facebook"></a></li> <li><a href="https://www.linkedin.com/company/certis-oncology" target="_blank" class="linkedin"></a></li> <li><a href="https://twitter.com/CertisOncology" target="_blank" class="twitter"></a></li> <li><a href="https://www.instagram.com/certis_oncology" target="_blank" class="instagram"></a></li> <li><a href="https://www.youtube.com/channel/UCeX4_jh3RlNKxQxZ89_utjg" target="_blank" class="youtube"></a></li> <li><a href="https://blog.certisoncology.com/" target="_blank" class="blog"></a></li> </ul> </div> <div class="d-flex justify-content-end"> <figure class="mouse mx-auto"> <img class="img-fluid d-block" src="/wp-content/themes/certis/images/certis-footer-mouse.svg"> </figure> </div> </div> <hr /> <div class="row"> <div class="col"> <div class="copyright mb-2 mb-sm-0"> <span class="d-block">©2024 Certis Oncology Solutions. All rights reserved.</span> <span class="font-italic">Testimonials appearing on this site reflect real-life experiences of those who have used our services. To protect their privacy, photos feature models.</span> </div> </div> </div> </div> </footer> <cookie-consent :content=""<p>We may use \u201ccookies,\u201d log files, clear gifs or other technologies to help personalize your online experience. For example, a cookie can help us to recall your specific information on subsequent visits. Other technologies allow us to determine which email subscribers click through and read our newsletters. For more information see our <a href=\"\/privacy-policy\/\">Privacy Policy and <\/a><a href=\"\/privacy-policy\/#cookie-statement\">Cookie Statement<\/a><a href=\"\/privacy-policy\/\">.<\/a><\/p>\n""></cookie-consent> </div><!-- end vue app --> <!-- app --> <script crossorigin="anonymous" src="https://polyfill.io/v3/polyfill.min.js?features=es6%2Ces5%2CURL%2Ces7"></script> <script src="https://maps.googleapis.com/maps/api/js?key=AIzaSyCO3sLhHX6ZWiN5jQAYrGQk_7nXYBhBJac"></script> <script src="/wp-content/themes/certis/dist/js/app.js?v2"></script> </body> </html>