Custom Models for Preclinical Studies

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Precision radiation also can be employed in the laboratory to understand the effects of radiosensitizers and radioprotectors, and to develop predictive biomarkers of radiation sensitivity.<\/p>\n","cta":{"title":"LEARN MORE","url":"https:\/\/www.certisoncology.com\/innovations-in-glioblastoma-mouse-model-development\/","target":""}}],"media-option":"image","image":{"image":{"ID":2916,"id":2916,"title":"Xray image","filename":"Xray-image--e1706735857204.png","filesize":122533,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging\/xray-image\/","alt":"","author":"3","description":"","caption":"","name":"xray-image","status":"inherit","uploaded_to":2686,"date":"2021-06-08 23:03:08","modified":"2021-06-08 23:03:34","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":437,"height":350,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","medium-width":300,"medium-height":240,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","medium_large-width":437,"medium_large-height":350,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","large-width":437,"large-height":350,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","1536x1536-width":437,"1536x1536-height":350,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","2048x2048-width":437,"2048x2048-height":350,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","small-width":437,"small-height":350,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--486x540.png","square-sm-width":486,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","square-md-width":437,"square-md-height":350,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","portrait-width":437,"portrait-height":350,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Xray-image--e1706735857204.png","landscape-width":437,"landscape-height":350}},"href":{"title":"LEARN MORE","url":"https:\/\/www.certisoncology.com\/innovations-in-gbm-model-development\/","target":""},"title":"Using Targeted Radiation Technology ","description":"<p>The Precision X-Rad 320 radiator sports a homogeneous beam that delivers a precise radiation dose to either cell cultures or mouse models to prepare them for pharmacology.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":" ","entry":"<h2>Beyond a One-Size-Fits-All Approach:<\/h2>\n<h2>Advanced Cancer Models<\/h2>\n<p>Advanced antineoplastics, such as antistromal therapies<span class=\"tooltip\"><sup id=\"5785\">2<\/sup><\/span>, require advanced cancer models that take into account the tumor microenvironment. Developing the most clinically relevant, custom model begins with sourcing the most relevant tumor specimen from the <a href=\"https:\/\/www.certisoncology.com\/for-drug-developers\/tumor-bank\/\">BarneyOI Cancer Model Database<sup>\u00ae<\/sup><\/a>. The Certis tumor bank covers a wide range of cancer types and disease states, including treatment-na\u00efve,pretreated, as well as primary and metastatic tumors. Reduce variability between\u202f<em>in vitro<\/em>\u202fand<em>\u202fin vivo<\/em>\u202fstudies by pairing patient-derived xenograft (PDX)\u202fmodels with\u202ftheir matching PDX-derived\u202f3D cell cultures.<\/p>\n","cta":{"title":"Request Access","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/cancer-models-preclinical-studies\/","target":""}}],"media-option":"image","image":{"image":{"ID":6076,"id":6076,"title":"Orthotopic_liver-to-liver-icon-optimized","filename":"Orthotopic_liver-to-liver-icon-optimized.webp","filesize":91798,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized.webp","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/custom-model-development\/orthotopic_liver-to-liver-icon-optimized\/","alt":"Orthotopic_liver-to-liver-icon","author":"6","description":"Orthotopic_liver-to-liver-icon","caption":"Orthotopic_liver-to-liver-icon","name":"orthotopic_liver-to-liver-icon-optimized","status":"inherit","uploaded_to":137,"date":"2024-01-23 22:15:30","modified":"2024-01-23 22:15:41","menu_order":0,"mime_type":"image\/webp","type":"image","subtype":"webp","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":947,"height":521,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized-150x150.webp","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized-720x396.webp","medium-width":300,"medium-height":165,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized-768x423.webp","medium_large-width":768,"medium_large-height":423,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized.webp","large-width":947,"large-height":521,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized.webp","1536x1536-width":947,"1536x1536-height":521,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized.webp","2048x2048-width":947,"2048x2048-height":521,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized-540x297.webp","small-width":540,"small-height":297,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized-540x521.webp","square-sm-width":540,"square-sm-height":521,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized-720x521.webp","square-md-width":720,"square-md-height":521,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized-640x521.webp","portrait-width":640,"portrait-height":521,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Orthotopic_liver-to-liver-icon-optimized.webp","landscape-width":947,"landscape-height":521}},"href":{"title":"LEARN MORE","url":"https:\/\/www.certisoncology.com\/innovations-in-gbm-model-development\/","target":""},"title":" Modeling Clinical Relevance with Orthotopic PDX","description":"<p>Orthotopic patient-derived xenograft models not only mirror human tumor biology better than legacy models, they can also accurately predict drug response, drug resistance, and metastatic proliferation.<span class=\"tooltip\"><sup id=\"3781\">3<\/sup><\/span><span class=\"tooltip\"><sup id=\"3810\">4<\/sup><\/span><span class=\"tooltip\"><sup id=\"3811\">5<\/sup><\/span><span class=\"tooltip\"><sup id=\"3784\">6<\/sup><\/span> Certis scientists have spent years perfecting the art of orthotopic engraftment, using novel surgical techniques and sophisticated animal husbandry protocols to optimize cohort viability.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e40ba1bdc4 :arr="{"title":" ","content":"","headline":"Custom Models: Answers to Frequently Asked Questions\u00a0","items":[{"ID":3366,"post_author":"6","post_date":"2021-09-17 18:23:59","post_date_gmt":"2021-09-17 18:23:59","post_content":"<p>Yes, Certis is well-versed at developing custom models from tissue provided by our clients. Whether it is a patient biopsy from a clinical trial, a cryopreserved fragment of a patient-derived xenograft you have been working on in-house, an engineered cell line, or a commercially available cell line*, Certis can develop a model out of that tissue. Please reach out to <a href=\"mailto:busdev@certisoncology.com\" target=\"_blank\" rel=\"noopener\">busdev@certisoncology.com<\/a> to discuss a custom model build from your tissue of interest.<\/p>\n<p>*Some commercial cell lines may require special licenses and will be examined on a case-by-case basis.<\/p>\n","post_title":"Can Certis build a custom model from tissue that I send to you?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-certis-build-a-custom-model-from-tissue-that-i-send-to-you","to_ping":"","pinged":"","post_modified":"2024-02-16 18:49:05","post_modified_gmt":"2024-02-16 18:49:05","post_content_filtered":"","post_parent":3382,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3366","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3341,"post_author":"6","post_date":"2021-09-17 17:34:16","post_date_gmt":"2021-09-17 17:34:16","post_content":"<p>Yes, Certis can ectopically implant in your location of choice. Whether you are looking to model an experimental metastasis of a specific cancer indication or are interested in understanding the bioavailability of your compound in a different location than the tumor originated, Certis scientists will work with you to customize an ectopic model that meets your needs.<\/p>\n<p>Some prior examples include Melanoma PDX or BT474 HER2+ breast cancer implanted stereotactically in the brain, PDX models engrafted in the liver, pancreas, or abdomen, bone xenografts, and more.<\/p>\n","post_title":"Can Certis build ectopic models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-certis-build-ectopic-models","to_ping":"","pinged":"","post_modified":"2024-02-16 18:51:10","post_modified_gmt":"2024-02-16 18:51:10","post_content_filtered":"","post_parent":3382,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3341","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3344,"post_author":"6","post_date":"2021-09-17 17:39:07","post_date_gmt":"2021-09-17 17:39:07","post_content":"<p>Yes, you can request a specific mouse strain for your study. Certis has performed studies using NOD\/SCID, CB17\/SCID and nude mice strains. We can order other immunodeficient mouse strains as requested, depending on your specific needs.<\/p>\n","post_title":"Can I request a specific mouse strain?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-i-request-a-specific-mouse-strain","to_ping":"","pinged":"","post_modified":"2021-09-17 21:04:00","post_modified_gmt":"2021-09-17 21:04:00","post_content_filtered":"","post_parent":3382,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3344","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3375,"post_author":"6","post_date":"2021-09-17 19:28:26","post_date_gmt":"2021-09-17 19:28:26","post_content":"\n<p>While PDX orthotopic models have gained prominence in basic and translational oncology research over the last decade, industry continues to rely heavily on subcutaneous PDX mouse models because they are easier to implant and tumors are readily accessible for manual caliper measurement.<sup>1<\/sup> However, manual measurement is inherently prone to variability and inconsistencies introduced by analyst technique and skill. That subjectivity can dramatically influence scientific conclusions.<sup>2 3<\/sup><\/p>\n\n\n\n<p>At Certis, we believe the stakes of preclinical drug development warrant the most clinically relevant models and most precise measurements. That is why we champion the use of orthotopic PDX models for pivotal pharmacology studies and murine-scale MRI for tumor volume measurements.<\/p>\n\n\n\n<p><strong>1<\/strong> Lai Y, Wei X, Lin S, Qin L, Cheng L, Li P. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3998\" target=\"_blank\" rel=\"noreferrer noopener\">Current Status and Perspectives of Patient-Derived Xenograft Models in Cancer Research<\/a>. <em>J Hematol Oncol<\/em>. 2017;10(1):106.<br><strong>2<\/strong> Kersemans V, Cornelissen B, Allen PD, Beech JS, Smart SC. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3799\" target=\"_blank\" rel=\"noreferrer noopener\">Subcutaneous Tumor Volume Measurement in the Awake, Manually Restrained Mouse Using MRI<\/a>. <em>J Magn Reson Imaging<\/em>. 2013;37(6):1499-1504.<br><strong>3<\/strong> Ayers GD, McKinley ET, Zhao P, et al. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3800\" target=\"_blank\" rel=\"noreferrer noopener\">Volume of Preclinical Xenograft Tumors is More Accurately Assessed by Ultrasound Imaging than Manual Caliper Measurements<\/a>. <em>J Ultrasound Med<\/em>. 2010;29(6):891-901.<\/p>\n","post_title":"If patient-derived xenograft orthotopic models are superior to patient-derived xenograft subcutaneous mouse models, why does the industry still rely so heavily on subcutaneous PDX models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"if-orthotopic-pdx-models-are-superior-to-subcutaneous-pdx-models-why-does-the-industry-still-rely-so-heavily-on-subcutaneous-pdx-models","to_ping":"","pinged":"","post_modified":"2024-02-19 19:59:04","post_modified_gmt":"2024-02-19 19:59:04","post_content_filtered":"","post_parent":3382,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3375","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3381,"post_author":"6","post_date":"2021-09-17 19:59:19","post_date_gmt":"2021-09-17 19:59:19","post_content":"<p>The majority of Certis preclinical studies using orthotopic models are conducted using triple immunodeficient NOG mice (NOD.Cg-Prkdc<sup>scid<\/sup> Il2rg<sup>tm1Sug<\/sup>\/JicTac) sourced from Taconic Biosciences. We have also established partnerships with other vendors, which allows us to source other immunodeficient mouse strains to meet your requirements.<\/p>\n","post_title":"In what mouse strain are preclinical studies with orthotopic models typically run?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"in-what-mouse-strain-are-o-pdx-studies-typically-run","to_ping":"","pinged":"","post_modified":"2024-02-16 18:56:35","post_modified_gmt":"2024-02-16 18:56:35","post_content_filtered":"","post_parent":3382,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3381","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3389,"post_author":"6","post_date":"2021-09-17 22:14:17","post_date_gmt":"2021-09-17 22:14:17","post_content":"\n<p>Patient-derived xenograft orthotopic models are more clinically relevant than traditional PDX or CDX models\u202fbecause they<sup>1-4<\/sup>:<\/p>\n\n\n\n<p>Preserve the histological architecture, stroma construction<sup>5-8<\/sup>, and gene-expression or mutation status of the original tumor tissue.<sup>7-10<\/sup><\/p>\n\n\n\n<p>Replicate the human tumor microenvironment (TME), which is critical to cancer progression and metastasis, and for assessing therapies that involve components of TME.<sup>5<\/sup><\/p>\n\n\n\n<p>Can predict the development of resistance to first-line therapy and response to second-line therapy \u2013 before these events are observed in patients.<sup>7,11<\/sup><\/p>\n\n\n\n<p>Patient-derived xenograft orthotopic models have gained prominence in basic and translational oncology research.<sup>5,12<\/sup><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<p><strong>1<\/strong> Byrne AT, Alf\u00e9rez DG, Amant F, et al. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3810\" target=\"_blank\" rel=\"noreferrer noopener\">Interrogating Open Issues in Cancer Precision Medicine with Patient-Derived Xenografts<\/a>. <em>Nat Rev Cancer<\/em>. 2017;17(4):254-268.<br><strong>2<\/strong> DeRose YS, Wang G, Lin YC, et al. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3781\" target=\"_blank\" rel=\"noreferrer noopener\">Tumor Grafts Derived from Women with Breast Cancer Authentically Reflect Tumor Pathology, Growth, Metastasis and Disease Outcomes<\/a>. <em>Nat Med<\/em>. 2011;17(11):1514-1520.<br><strong>3<\/strong> Joo KM, Kim J, Jin J, et al. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3784\" target=\"_blank\" rel=\"noreferrer noopener\">Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ<\/a>. <em>Cell Rep<\/em>. 2013;3(1):260-273.<br><strong>4<\/strong> Du Q, Jiang L, Wang XQ, Pan W, She FF, Chen YL. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3784\" target=\"_blank\" rel=\"noreferrer noopener\">Establishment of and Comparison Between Orthotopic Xenograft and Subcutaneous Xenograft Models of Gallbladder Carcinoma<\/a>. <em>Asian Pac J Cancer Prev<\/em>. 2014;15(8):3747-3752.<br><strong>5<\/strong> Long JE, Jankovic M, Maddalo D. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3782\" target=\"_blank\" rel=\"noreferrer noopener\">Drug Discovery Oncology in a Mouse: Concepts, Models and Limitations<\/a>. <em>Future Sci OA<\/em>. 2021;7(8):FSO737.<br><strong>6<\/strong> Nakano, K., Nishizawa, T., Komura, D., Fujii, E., Monnai, M., Kato, A., Funahashi, S. I., Ishikawa, S., & Suzuki, M. (2018). <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3513\" target=\"_blank\" rel=\"noreferrer noopener\">Difference in Morphology and Interactome Profiles Between Orthotopic and Subcutaneous Gastric Cancer Xenograft Models<\/a>. J of Toxicologic Pathology, 31(4), 293\u2013300.<br><strong>7<\/strong> Julien S, Merino-Trigo A, Lacroix L, et al. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3780\" target=\"_blank\" rel=\"noreferrer noopener\">Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer<\/a>.<em> Clin Cancer Res<\/em>. 2012;18(19):5314-5328.<br><strong>8<\/strong> Walters DM, Stokes JB, Adair SJ, et al. <a href=\"http:\/\/certisoncology.com\/resources\/supporting-research\/#3769\" target=\"_blank\" rel=\"noreferrer noopener\">Clinical, Molecular and Genetic Validation of a Murine Orthotopic Xenograft Model of Pancreatic Adenocarcinoma Using Fresh Human Specimens<\/a>. <em>PLoS One<\/em>. 2013;8(10): e77065.<br><strong>9<\/strong> Zhao X, Liu Z, Yu L, et al. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3784\" target=\"_blank\" rel=\"noreferrer noopener\">Global Gene Expression Profiling Confirms the Molecular Fidelity of Primary Tumor-Based Orthotopic Xenograft Mouse Models of Medulloblastoma<\/a>. <em>Neuro Oncol<\/em>. 2012;14(5):574-583.<br><strong>10<\/strong> Shankavaram UT, Bredel M, Burgan WE, Carter D, Tofilon P, Camphausen K. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#4022\" target=\"_blank\" rel=\"noreferrer noopener\">Molecular Profiling Indicates Orthotopic Xenograft of Glioma Cell Lines Simulate a Subclass of Human Glioblastom<\/a>a. <em>J Cell Mol Med.<\/em> 2012;16(3):545-554.<br><strong>11<\/strong> Tran Chau, V., Liu, W., Gerb\u00e9 de Thor\u00e9, M., Meziani, L., Mondini, M., O’Connor, M. J., Deutsch, E., & Cl\u00e9menson, C. (2020). <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3271\" target=\"_blank\" rel=\"noreferrer noopener\">Differential Therapeutic Effects of PARP and ATR Inhibition Combined with Radiotherapy in the Treatment of Subcutaneous Versus Orthotopic Lung Tumor Models<\/a>. British J of Cancer, 123(5), 762\u2013771.<br><strong>12<\/strong>\u00a0Killion, J\u00a0J, Radinsky, R, Fidler, I J.\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1023%2FA%3A1006140513233\" target=\"_blank\" rel=\"noreferrer noopener\">Orthotopic Models are Necessary to Predict Therapy of Transplantable Tumors in Mice<\/a>.\u00a0<em>Cancer Metastasis Rev.<\/em>\u00a01998;17<strong>:<\/strong>279\u2013284\u00a0<a href=\"https:\/\/doi.org\/10.1023\/A:1006140513233\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1023\/A:1006140513233<\/a>.<\/p>\n","post_title":"What makes orthotopic patient-derived xenograft (O-PDX) models more clinically relevant than traditional patient-derived xenograft (PDX) or cell-derived xenograft (CDX) models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-makes-orthotopic-patient-derived-xenograft-o-pdx-models-better-than-traditional-patient-derived-xenograft-pdx-or-cell-derived-xenograft-cdx-models","to_ping":"","pinged":"","post_modified":"2024-02-28 00:45:08","post_modified_gmt":"2024-02-28 00:45:08","post_content_filtered":"","post_parent":3382,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3389","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3340,"post_author":"6","post_date":"2021-09-17 17:32:19","post_date_gmt":"2021-09-17 17:32:19","post_content":"<p>Certis implants both tumor chunk and single-cell suspensions, depending on the circumstances. Certis implants tumor chunks of approximately 2-3mm when possible, as this technique helps preserve the original tumor\u2019s histological architecture and stroma construction, cell-cell ,adhesions, and cell-type composition. Orthotopic engraftment further improves clinical relevance through recapitulation of the tumor microenvironment. If implantation of a tumor chunk is not possible, we use single-cell suspensions. Clinically annotated patient-derived xenograft (PDX) models are generated from tumor cells isolated from the ascites or pleural fluid of patients undergoing clinical procedures. Currently, single-cell suspensions are used for brain, bone and lung model development.<\/p>\n","post_title":"When creating PDX models, does Certis implant tumor fragments or single-cell suspensions?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"when-creating-pdx-models-does-certis-implant-tumor-fragments-or-single-cell-suspensions","to_ping":"","pinged":"","post_modified":"2024-02-16 19:00:24","post_modified_gmt":"2024-02-16 19:00:24","post_content_filtered":"","post_parent":3382,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3340","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6078,"post_author":"6","post_date":"2024-01-23 22:24:06","post_date_gmt":"2024-01-23 22:24:06","post_content":"\n<p>Yes, you can send Certis a custom antibody for validation, as well as for protocol transfer, method validation and method optimization services.<\/p>\n","post_title":"Does Certis offer custom antibody services?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"does-certis-offer-custom-antibody-services","to_ping":"","pinged":"","post_modified":"2024-01-23 22:24:06","post_modified_gmt":"2024-01-23 22:24:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6078","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3349,"post_author":"6","post_date":"2021-09-17 17:47:29","post_date_gmt":"2021-09-17 17:47:29","post_content":"<p>Certis can send you FFPE slides and snap frozen tissue samples for your in-house histology or protein analysis. A small shipping and handling fee will apply. You may also engage Certis directly to validate your custom antibody in our CLIA-certified lab.<\/p>\n","post_title":"I have a custom antibody. What kinds of samples will Certis send me so I can validate expression in house?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"i-have-a-custom-antibody-what-kinds-of-samples-will-certis-send-me-so-i-can-validate-expression-in-house","to_ping":"","pinged":"","post_modified":"2024-02-16 19:01:41","post_modified_gmt":"2024-02-16 19:01:41","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3349","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3352,"post_author":"6","post_date":"2021-09-17 17:58:24","post_date_gmt":"2021-09-17 17:58:24","post_content":"\n<p>Certis provides intravenous, oral, continuous (ALZET<sup>\u00ae<\/sup> pump) infusion, and radiotherapy routes of administration. Please let us know if you require an alternative dosing method.<\/p>\n","post_title":"What routes of administration does Certis offer?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-kind-of-routes-of-administration-can-i-use-to-dose-my-test-agent","to_ping":"","pinged":"","post_modified":"2024-02-16 19:04:21","post_modified_gmt":"2024-02-16 19:04:21","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3352","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"}],"cta":"","layout":{"background":"","background-offset":""}}"></component-5f6e40ba1bdc4><component-5f7e3c2a849f9 :arr="{"title":"Talk to Us Today About Increasing Translational Relevance with Custom Model Development","description":"<h3 id=\"Enter-your-information\">Enter your information<a 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