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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="YOkKNnlj06h75XSeJzV0KPKn43EpZ2CGUjMSf8IZl/W33Py5Uj+0EhaBUwa1VhtuQF2G8lw+NjOXEH6CpYb8Ag==" /> <meta name="citation_title" content="Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration" /> <meta name="citation_publication_date" content="2015" /> <meta name="citation_journal_title" content="Journal of Clinical Virology" /> <meta name="citation_author" content="Meng-Hsiu Yen" /> <meta name="citation_author" content="Yhu-Chering Huang" /> <meta name="citation_author" content="Min-Chi Chen" /> <meta name="citation_author" content="Ching-Chuan Liu" /> <meta name="citation_author" content="Nan-Chang Chiu" /> <meta name="citation_author" content="Reyin Lien" /> <meta name="citation_author" content="Luan-Yin Chang" /> <meta name="citation_author" content="Cheng-Hsun Chiu" /> <meta name="citation_author" content="Kuo-Chien Tsao" /> <meta name="citation_author" content="Tzou-Yien Lin" /> <meta name="citation_volume" content="64" /> <meta name="citation_firstpage" content="92-96" /> <meta name="citation_issn" content="1386-6532" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/14115145/Effect_of_intravenous_immunoglobulin_for_neonates_with_severe_enteroviral_infections_with_emphasis_on_the_timing_of_administration" /> <meta name="twitter:title" content="Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration" /> <meta name="twitter:description" content="The benefits of intravenous immunoglobulin (IVIG) therapy for severe neonatal enterovirus infections are still controversial. To evaluate whether timing of IVIG administration might affect clinical outcomes of neonates with severe enteroviral" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/14115145/Effect_of_intravenous_immunoglobulin_for_neonates_with_severe_enteroviral_infections_with_emphasis_on_the_timing_of_administration" /> <meta property="og:title" content="Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="The benefits of intravenous immunoglobulin (IVIG) therapy for severe neonatal enterovirus infections are still controversial. To evaluate whether timing of IVIG administration might affect clinical outcomes of neonates with severe enteroviral" /> <meta property="article:author" content="https://taiwan.academia.edu/LuanyinChang" /> <meta name="description" content="The benefits of intravenous immunoglobulin (IVIG) therapy for severe neonatal enterovirus infections are still controversial. To evaluate whether timing of IVIG administration might affect clinical outcomes of neonates with severe enteroviral" /> <title>(PDF) Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration | Luan-yin Chang - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/14115145/Effect_of_intravenous_immunoglobulin_for_neonates_with_severe_enteroviral_infections_with_emphasis_on_the_timing_of_administration" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732466749000); window.Aedu.timeDifference = new Date().getTime() - 1732466749000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"The benefits of intravenous immunoglobulin (IVIG) therapy for severe neonatal enterovirus infections are still controversial. To evaluate whether timing of IVIG administration might affect clinical outcomes of neonates with severe enteroviral infections. We retrospectively analyzed 67 neonates with culture-confirmed severe enteroviral infection, defined as hepatitis with coagulopathy and thrombocytopenia. Clinical features, outcomes and the usage of IVIG therapy were collected and analyzed. IVIG administered within 3 days of illness onset was classified as early IVIG therapy. Of the 67 cases, 38 (57%) were male, 27 (40%) were premature, 57 (85%) had disease onset within 7 days of life and all but 2 cases were caused by coxsackievirus B group. Ten infants (15%) had clinically evident myocarditis. 41 infants (61%) received IVIG therapy and 29 were early IVIG therapy. Fifteen infants (22%) eventually died, without IVIG therapy for 7 infants. The deceased had a significantly higher peak...","author":[{"@context":"https://schema.org","@type":"Person","name":"Luan-yin Chang"}],"contributor":[],"dateCreated":"2015-07-16","dateModified":"2015-07-16","datePublished":"2015-01-01","headline":"Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration","inLanguage":"en","keywords":[],"locationCreated":null,"publication":"Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/14115145/Effect_of_intravenous_immunoglobulin_for_neonates_with_severe_enteroviral_infections_with_emphasis_on_the_timing_of_administration","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"taiwan"}]}</script><link rel="stylesheet" media="all" 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{"work":{"id":14115145,"created_at":"2015-07-16T07:34:05.083-07:00","from_world_paper_id":139609151,"updated_at":"2021-01-18T00:17:06.890-08:00","_data":{"abstract":"The benefits of intravenous immunoglobulin (IVIG) therapy for severe neonatal enterovirus infections are still controversial. To evaluate whether timing of IVIG administration might affect clinical outcomes of neonates with severe enteroviral infections. We retrospectively analyzed 67 neonates with culture-confirmed severe enteroviral infection, defined as hepatitis with coagulopathy and thrombocytopenia. Clinical features, outcomes and the usage of IVIG therapy were collected and analyzed. IVIG administered within 3 days of illness onset was classified as early IVIG therapy. Of the 67 cases, 38 (57%) were male, 27 (40%) were premature, 57 (85%) had disease onset within 7 days of life and all but 2 cases were caused by coxsackievirus B group. Ten infants (15%) had clinically evident myocarditis. 41 infants (61%) received IVIG therapy and 29 were early IVIG therapy. Fifteen infants (22%) eventually died, without IVIG therapy for 7 infants. The deceased had a significantly higher peak...","publication_date":"2015,,","publication_name":"Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [33115704]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":44588958,"attachmentType":"pdf"}"><img alt="First page of “Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/44588958/mini_magick20190214-787-awa2fn.png?1550149914" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="33115704" href="https://taiwan.academia.edu/LuanyinChang"><img alt="Profile image of Luan-yin Chang" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Luan-yin Chang</a></div><p class="ds-work-card--detail ds2-5-body-sm">2015, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The benefits of intravenous immunoglobulin (IVIG) therapy for severe neonatal enterovirus infections are still controversial. To evaluate whether timing of IVIG administration might affect clinical outcomes of neonates with severe enteroviral infections. We retrospectively analyzed 67 neonates with culture-confirmed severe enteroviral infection, defined as hepatitis with coagulopathy and thrombocytopenia. Clinical features, outcomes and the usage of IVIG therapy were collected and analyzed. IVIG administered within 3 days of illness onset was classified as early IVIG therapy. Of the 67 cases, 38 (57%) were male, 27 (40%) were premature, 57 (85%) had disease onset within 7 days of life and all but 2 cases were caused by coxsackievirus B group. Ten infants (15%) had clinically evident myocarditis. 41 infants (61%) received IVIG therapy and 29 were early IVIG therapy. Fifteen infants (22%) eventually died, without IVIG therapy for 7 infants. The deceased had a significantly higher peak...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":44588958,"attachmentType":"pdf","workUrl":"https://www.academia.edu/14115145/Effect_of_intravenous_immunoglobulin_for_neonates_with_severe_enteroviral_infections_with_emphasis_on_the_timing_of_administration"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":44588958,"attachmentType":"pdf","workUrl":"https://www.academia.edu/14115145/Effect_of_intravenous_immunoglobulin_for_neonates_with_severe_enteroviral_infections_with_emphasis_on_the_timing_of_administration"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="44588958" data-landing_url="https://www.academia.edu/14115145/Effect_of_intravenous_immunoglobulin_for_neonates_with_severe_enteroviral_infections_with_emphasis_on_the_timing_of_administration" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="14115115" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14115115/Neonatal_enterovirus_infections_emphasis_on_risk_factors_of_severe_and_fatal_infections">Neonatal enterovirus infections: emphasis on risk factors of severe and fatal infections</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33115704" href="https://taiwan.academia.edu/LuanyinChang">Luan-yin Chang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Pediatric Infectious Disease Journal, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal enterovirus infections: emphasis on risk factors of severe and fatal infections","attachmentId":44588972,"attachmentType":"pdf","work_url":"https://www.academia.edu/14115115/Neonatal_enterovirus_infections_emphasis_on_risk_factors_of_severe_and_fatal_infections","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14115115/Neonatal_enterovirus_infections_emphasis_on_risk_factors_of_severe_and_fatal_infections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="70598017" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/70598017/Enteroviral_Infections_in_the_First_Three_Months_of_Life">Enteroviral Infections in the First Three Months of Life</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="136500566" href="https://independent.academia.edu/AlbertoBerardi2">Alberto Berardi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pathogens</p><p class="ds-related-work--abstract ds2-5-body-sm">Enteroviruses (EVs) are an important source of infection in the paediatric age, with most cases concerning the neonatal age and early infancy. Molecular epidemiology is crucial to understand the circulation of main serotypes in a specific area and period due to their extreme epidemiological variability. The diagnosis of EVs infection currently relies on the detection of EVs RNA in biological samples (usually cerebrospinal fluid and plasma, but also throat swabs and feces) through a polymerase chain reaction assay. Although EVs infections usually have a benign course, they sometimes become life threatening, especially when symptoms develop in the first few days of life. Mortality is primarily associated with myocarditis, acute hepatitis, and multi-organ failure. Neurodevelopmental sequelae have been reported following severe infections with central nervous system involvement. Unfortunately, at present, the treatment of EVs infections is mainly supportive. The use of specific antivira...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Enteroviral Infections in the First Three Months of Life","attachmentId":80283223,"attachmentType":"pdf","work_url":"https://www.academia.edu/70598017/Enteroviral_Infections_in_the_First_Three_Months_of_Life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/70598017/Enteroviral_Infections_in_the_First_Three_Months_of_Life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="78303241" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/78303241/Clinical_usage_of_intravenous_immunoglobulin_in_neonates_in_a_tertiary_care_centre_a_retrospective_observational_study">Clinical usage of intravenous immunoglobulin in neonates in a tertiary care centre: a retrospective observational study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="9031392" href="https://independent.academia.edu/BADREDDINEBOUSBIA">BADREDDINE BOUSBIA</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Contemporary Pediatrics, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Intravenous Immunoglobulin (IVIG) is a blood product manufactured from pooled plasma. With increasing availability, an increased usage in neonates is being noted, though its utilisation has not been audited thoroughly. The objectives of this study are to describe the usage pattern and indications of IVIG and its outcome in a state-run tertiary care NICU.Methods: This retrospective observational study was carried out at the inborn unit of Department of Neonatology, Madras Medical College, Chennai on a cohort of neonates who received IVIG over 3.5 years from January 2016 to June 2019. Data was collected from drug register, neonatal case records, exchange transfusion register and death register.Results: Our study cohort had 55 neonates who received IVIG over 3.5 years. Indications for IVIG usage were Rh-alloimmunisation (23), ABO-alloimmunisation (7), prophylaxis of perinatal varicella (20), and other immune thrombocytopenia (5). Among 30 neonates with ABO-/Rh-incompatibili...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Clinical usage of intravenous immunoglobulin in neonates in a tertiary care centre: a retrospective observational study","attachmentId":85397721,"attachmentType":"pdf","work_url":"https://www.academia.edu/78303241/Clinical_usage_of_intravenous_immunoglobulin_in_neonates_in_a_tertiary_care_centre_a_retrospective_observational_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/78303241/Clinical_usage_of_intravenous_immunoglobulin_in_neonates_in_a_tertiary_care_centre_a_retrospective_observational_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="95575306" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/95575306/Enteroviral_Infections_in_Infants">Enteroviral Infections in Infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="203844642" href="https://independent.academia.edu/SrijanSingh51">Srijan Singh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Newborn</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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study","attachmentId":72610218,"attachmentType":"pdf","work_url":"https://www.academia.edu/57971821/Clinical_characterization_of_neonatal_and_pediatric_enteroviral_infections_an_Italian_single_center_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/57971821/Clinical_characterization_of_neonatal_and_pediatric_enteroviral_infections_an_Italian_single_center_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="58184450" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/58184450/Intravenous_Immunoglobulin_and_Necrotizing_Enterocolitis_in_Newborns_With_Hemolytic_Disease">Intravenous Immunoglobulin and Necrotizing Enterocolitis in Newborns With Hemolytic Disease</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42202147" href="https://independent.academia.edu/FBotetmussons">F. Botet-mussons</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PEDIATRICS, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intravenous Immunoglobulin and Necrotizing Enterocolitis in Newborns With Hemolytic Disease","attachmentId":72718243,"attachmentType":"pdf","work_url":"https://www.academia.edu/58184450/Intravenous_Immunoglobulin_and_Necrotizing_Enterocolitis_in_Newborns_With_Hemolytic_Disease","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/58184450/Intravenous_Immunoglobulin_and_Necrotizing_Enterocolitis_in_Newborns_With_Hemolytic_Disease"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="50832753" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/50832753/L_administration_d_immunoglobulines_intraveineuses_n_est_pas_sans_risque_durant_la_p%C3%A9riode_n%C3%A9onatale">L’administration d’immunoglobulines intraveineuses n’est pas sans risque durant la période néonatale</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="194962700" href="https://independent.academia.edu/CostantinoDeGiacomo">Costantino De Giacomo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives de Pédiatrie, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"L’administration d’immunoglobulines intraveineuses n’est pas sans risque durant la période néonatale","attachmentId":68699995,"attachmentType":"pdf","work_url":"https://www.academia.edu/50832753/L_administration_d_immunoglobulines_intraveineuses_n_est_pas_sans_risque_durant_la_p%C3%A9riode_n%C3%A9onatale","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/50832753/L_administration_d_immunoglobulines_intraveineuses_n_est_pas_sans_risque_durant_la_p%C3%A9riode_n%C3%A9onatale"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="52829753" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/52829753/Neonatal_Enterovirus_Infection_Case_Series_of_Clinical_Sepsis_and_Positive_Cerebrospinal_Fluid_Polymerase_Chain_Reaction_Test_with_Myocarditis_and_Cerebral_White_Matter_Injury_Complications">Neonatal Enterovirus Infection: Case Series of Clinical Sepsis and Positive Cerebrospinal Fluid Polymerase Chain Reaction Test with Myocarditis and Cerebral White Matter Injury Complications</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39179792" href="https://independent.academia.edu/FrankMorriss">Frank Morriss</a></div><p class="ds-related-work--metadata ds2-5-body-xs">AJP reports, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective We describe five neonates with enteroviral (EV) infection to demonstrate central nervous system (CNS) and cardiac complications and report successful treatment of myocarditis with immunoglobulin intravenous (IVIG) in two. Study Design Case series identified during three enteroviral seasons in one neonatal intensive care unit (NICU) by cerebral spinal fluid (CSF) reverse transcriptase polymerase chain reaction (PCR) testing for EV in neonates suspected to have sepsis, but with sterile bacterial cultures. Results Cases were identified in each of three sequential years in a NICU with 800 to 900 admissions/year. Two cases were likely acquired perinatally; all were symptomatic with lethargy and poor feeding by age 5 to 10 days. All had signs of sepsis and/or meningitis; one progressed to periventricular leukomalacia and encephalomalacia. Two recovered from myocarditis after treatment that included IVIG 3 to 5 g/kg. Conclusion Neonates who appear septic without bacterial etiolog...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal Enterovirus Infection: Case Series of Clinical Sepsis and Positive Cerebrospinal Fluid Polymerase Chain Reaction Test with Myocarditis and Cerebral White Matter Injury Complications","attachmentId":69905058,"attachmentType":"pdf","work_url":"https://www.academia.edu/52829753/Neonatal_Enterovirus_Infection_Case_Series_of_Clinical_Sepsis_and_Positive_Cerebrospinal_Fluid_Polymerase_Chain_Reaction_Test_with_Myocarditis_and_Cerebral_White_Matter_Injury_Complications","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/52829753/Neonatal_Enterovirus_Infection_Case_Series_of_Clinical_Sepsis_and_Positive_Cerebrospinal_Fluid_Polymerase_Chain_Reaction_Test_with_Myocarditis_and_Cerebral_White_Matter_Injury_Complications"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="9440950" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/9440950/Neonatal_Enterovirus_Infections_Reported_to_the_National_Enterovirus_Surveillance_System_in_the_United_States_1983_2003">Neonatal Enterovirus Infections Reported to the National Enterovirus Surveillance System in the United States, 1983???2003</a><div class="ds-related-work--metadata"><a 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class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/9440950/Neonatal_Enterovirus_Infections_Reported_to_the_National_Enterovirus_Surveillance_System_in_the_United_States_1983_2003"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="101632316" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/101632316/Necrotizing_enterocolitis_following_the_use_of_intravenous_immunoglobulin_for_haemolytic_disease_of_the_newborn">Necrotizing enterocolitis following the use of intravenous immunoglobulin for haemolytic disease of the newborn</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="269326364" href="https://independent.academia.edu/MarielNavarro32">Mariel Navarro</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Paediatrica, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Necrotizing enterocolitis following the use of intravenous immunoglobulin for haemolytic disease of the newborn","attachmentId":102119657,"attachmentType":"pdf","work_url":"https://www.academia.edu/101632316/Necrotizing_enterocolitis_following_the_use_of_intravenous_immunoglobulin_for_haemolytic_disease_of_the_newborn","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/101632316/Necrotizing_enterocolitis_following_the_use_of_intravenous_immunoglobulin_for_haemolytic_disease_of_the_newborn"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":44588958,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":44588958,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="107197053" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/107197053/High_dose_intravenous_immunoglobulin_therapy_in_neonatal_immune_haemolytic_jaundice">High-dose intravenous immunoglobulin therapy in neonatal immune haemolytic jaundice</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="190219403" href="https://independent.academia.edu/Laurencechan9">Laurence chan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Paediatrica, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"High-dose intravenous immunoglobulin therapy in neonatal 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