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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="Hq4Yp8kkAaHcVhijI/Gp27I+Qzy7SvXLfOFQIP+AbVL7pxVBLdPHk8nVAGOi5DqLmQ/74U3+NgGms+2lYN7J/Q==" /> <meta name="citation_title" content="Intravenous Immunoglobulin in Neonatal Sepsis" /> <meta name="citation_publication_date" content="2013" /> <meta name="citation_journal_title" content="Journal of Nepal Paediatric Society" /> <meta name="citation_author" content="Jiang Li" /> <meta name="citation_author" content="Mahesh Kumar Gautam" /> <meta name="citation_volume" content="33" /> <meta name="citation_issue" content="2" /> <meta name="citation_firstpage" content="125-128" /> <meta name="citation_issn" content="1990-7982" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis" /> <meta name="twitter:title" content="Intravenous Immunoglobulin in Neonatal Sepsis" /> <meta name="twitter:description" content="Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. 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Despite of advances in technology and optimal antibiotic treatment, incidence of neonatal" /> <meta property="article:author" content="https://independent.academia.edu/GautamMaheshKumar" /> <meta name="description" content="Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. Despite of advances in technology and optimal antibiotic treatment, incidence of neonatal" /> <title>(PDF) Intravenous Immunoglobulin in Neonatal Sepsis | Mahesh Kumar Gautam - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '92477ec68c09d28ae4730a4143c926f074776319'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732793138000); window.Aedu.timeDifference = new Date().getTime() - 1732793138000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. Despite of advances in technology and optimal antibiotic treatment, incidence of neonatal sepsis and its complications remains unacceptably high especially in developing countries. Premature neonates in particular are at higher risk due to developmentally immature host defense mechanisms. Though not approved by Food and Drug Administration (FDA) U.S.A, off label use of intravenous immunoglobulin continues in many countries. Recent evidences showed no significant decrease in the mortality rate or other outcomes when intravenous immunoglobulin is administered in addition to standard therapies. Hence, use of intravenous immunoglobulin in suspected or proven neonatal sepsis is not recommended. The expense of prophylactic use of intravenous immunoglobulin administration for both term and preterm newborn population, given the minimal be...","author":[{"@context":"https://schema.org","@type":"Person","name":"Mahesh Kumar Gautam"}],"contributor":[],"dateCreated":"2023-03-13","dateModified":"2023-03-13","datePublished":"2013-01-01","headline":"Intravenous Immunoglobulin in Neonatal Sepsis","inLanguage":"en","keywords":["Pediatrics","Medicine","Population","Sepsis","Neonatal Sepsis"],"locationCreated":null,"publication":"Journal of Nepal Paediatric Society","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Nepal Journals Online (JOL)"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F98441844%2FIntravenous_Immunoglobulin_in_Neonatal_Sepsis%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":99792213,"identifier":"Attachment_99792213","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":98441844,"created_at":"2023-03-13T06:34:03.551-07:00","from_world_paper_id":229514000,"updated_at":"2023-03-13T06:57:43.728-07:00","_data":{"abstract":"Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. Despite of advances in technology and optimal antibiotic treatment, incidence of neonatal sepsis and its complications remains unacceptably high especially in developing countries. Premature neonates in particular are at higher risk due to developmentally immature host defense mechanisms. Though not approved by Food and Drug Administration (FDA) U.S.A, off label use of intravenous immunoglobulin continues in many countries. Recent evidences showed no significant decrease in the mortality rate or other outcomes when intravenous immunoglobulin is administered in addition to standard therapies. Hence, use of intravenous immunoglobulin in suspected or proven neonatal sepsis is not recommended. The expense of prophylactic use of intravenous immunoglobulin administration for both term and preterm newborn population, given the minimal be...","publisher":"Nepal Journals Online (JOL)","publication_date":"2013,,","publication_name":"Journal of Nepal Paediatric Society"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Intravenous Immunoglobulin in Neonatal Sepsis","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [261377943]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":99792213,"attachmentType":"pdf"}"><img alt="First page of “Intravenous Immunoglobulin in Neonatal Sepsis”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/99792213/mini_magick20230313-1-1mx8r1d.png?1678714578" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Intravenous Immunoglobulin in Neonatal Sepsis</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="261377943" href="https://independent.academia.edu/GautamMaheshKumar"><img alt="Profile image of Mahesh Kumar Gautam" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/261377943/113240878/102510297/s65_mahesh_kumar.gautam.png" />Mahesh Kumar Gautam</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2013, Journal of Nepal Paediatric Society</p></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. Despite of advances in technology and optimal antibiotic treatment, incidence of neonatal sepsis and its complications remains unacceptably high especially in developing countries. Premature neonates in particular are at higher risk due to developmentally immature host defense mechanisms. Though not approved by Food and Drug Administration (FDA) U.S.A, off label use of intravenous immunoglobulin continues in many countries. Recent evidences showed no significant decrease in the mortality rate or other outcomes when intravenous immunoglobulin is administered in addition to standard therapies. Hence, use of intravenous immunoglobulin in suspected or proven neonatal sepsis is not recommended. The expense of prophylactic use of intravenous immunoglobulin administration for both term and preterm newborn population, given the minimal be...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":99792213,"attachmentType":"pdf","workUrl":"https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":99792213,"attachmentType":"pdf","workUrl":"https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="99792213" data-landing_url="https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="31871982" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31871982/Intravenous_immunoglobulin_for_prophylaxis_of_neonatal_sepsis_in_premature_infants">Intravenous immunoglobulin for prophylaxis of neonatal sepsis in premature infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="61544757" href="https://independent.academia.edu/MariaPastore5">Maria Pastore</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Disease in Childhood, 1988</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intravenous immunoglobulin for prophylaxis of neonatal sepsis in premature infants","attachmentId":52159805,"attachmentType":"pdf","work_url":"https://www.academia.edu/31871982/Intravenous_immunoglobulin_for_prophylaxis_of_neonatal_sepsis_in_premature_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/31871982/Intravenous_immunoglobulin_for_prophylaxis_of_neonatal_sepsis_in_premature_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="69160562" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/69160562/Effect_of_Intravenous_Immunoglobulin_in_Prevention_of_Preterm_Neonatal_Sepsis_A_Clinical_Trial_Study">Effect of Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis: A Clinical Trial Study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47645342" href="https://independent.academia.edu/saadathossein">hossein saadat</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Healthmedica, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis: A Clinical Trial Study","attachmentId":79362603,"attachmentType":"pdf","work_url":"https://www.academia.edu/69160562/Effect_of_Intravenous_Immunoglobulin_in_Prevention_of_Preterm_Neonatal_Sepsis_A_Clinical_Trial_Study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/69160562/Effect_of_Intravenous_Immunoglobulin_in_Prevention_of_Preterm_Neonatal_Sepsis_A_Clinical_Trial_Study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="93255343" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93255343/A_Study_to_Assess_the_Importance_of_Intravenous_Immunoglobulin_Ivig_as_an_Adjuvant_in_the_Treatment_of_Neonatal_Sepsis_in_Preterm_Babies">A Study to Assess the Importance of Intravenous Immunoglobulin (Ivig) as an Adjuvant in the Treatment of Neonatal Sepsis in Preterm Babies</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="250465137" href="https://independent.academia.edu/MannanMalik3">Mannan Malik</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Study to Assess the Importance of Intravenous Immunoglobulin (Ivig) as an Adjuvant in the Treatment of Neonatal Sepsis in Preterm Babies","attachmentId":96043012,"attachmentType":"pdf","work_url":"https://www.academia.edu/93255343/A_Study_to_Assess_the_Importance_of_Intravenous_Immunoglobulin_Ivig_as_an_Adjuvant_in_the_Treatment_of_Neonatal_Sepsis_in_Preterm_Babies","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/93255343/A_Study_to_Assess_the_Importance_of_Intravenous_Immunoglobulin_Ivig_as_an_Adjuvant_in_the_Treatment_of_Neonatal_Sepsis_in_Preterm_Babies"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="43962406" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/43962406/PHARMACEUTICAL_SCIENCES_SJIF_Impact_Factor_7_187_A_STUDY_TO_ASSESS_THE_IMPORTANCE_OF_INTRAVENOUS_IMMUNOGLOBULIN_IVIG_AS_AN_ADJUVANT_IN_THE_TREATMENT_OF_NEONATAL_SEPSIS_IN_PRETERM_BABIES_QR_code">PHARMACEUTICAL SCIENCES SJIF Impact Factor: 7.187 A STUDY TO ASSESS THE IMPORTANCE OF INTRAVENOUS IMMUNOGLOBULIN (IVIG) AS AN ADJUVANT IN THE TREATMENT OF NEONATAL SEPSIS IN PRETERM BABIES QR code</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="15402473" href="https://nagajunauniversity.academia.edu/Editoriajps">Editor iajps</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Newborn children conceived before 32 weeks of incubation are genuinely immune deficient with cord blood centralization of IgG being not as much as half contrasted with those found in infants conceived at full term. Furthermore, exceptionally preterm newborn children have lessened supplement components, polymorphonuclear chemotaxis and are obligated to debilitate their capacity pools. Goals and Goals: An attempt was made to conduct this planned study with accompanying goals to focus on administering IVIG in addition to antibiotics to improve the therapeutic consequences of sepsis in premature infants. Materials and Methods: Sixty preterm infants with sepsis were randomly assigned to study and control groups in the Neonatal Intensive Care Unit of Fauji Foundation Hospital, Rawalpindi for one-year duration from May 2019 to April 2020. The study group was given IVIG in addition to standard treatment. Results: A total of 60 patients were enrolled, 30 in the study and 30 in the control group. There were no differences between the sexes (male 50%, females 50%) of the included newborns, which is also visible in the study (men 47.7%, women 52.3%) and the control group (males 52.3%, females 47.7 %). Conclusion: The low level of immunity in premature babies causes increased morbidity and mortality in severe infections. Using IVIG along with antibiotics and other supportive therapies may improve outcome.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"PHARMACEUTICAL SCIENCES SJIF Impact Factor: 7.187 A STUDY TO ASSESS THE IMPORTANCE OF INTRAVENOUS IMMUNOGLOBULIN (IVIG) AS AN ADJUVANT IN THE TREATMENT OF NEONATAL SEPSIS IN PRETERM BABIES QR code","attachmentId":64289846,"attachmentType":"pdf","work_url":"https://www.academia.edu/43962406/PHARMACEUTICAL_SCIENCES_SJIF_Impact_Factor_7_187_A_STUDY_TO_ASSESS_THE_IMPORTANCE_OF_INTRAVENOUS_IMMUNOGLOBULIN_IVIG_AS_AN_ADJUVANT_IN_THE_TREATMENT_OF_NEONATAL_SEPSIS_IN_PRETERM_BABIES_QR_code","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/43962406/PHARMACEUTICAL_SCIENCES_SJIF_Impact_Factor_7_187_A_STUDY_TO_ASSESS_THE_IMPORTANCE_OF_INTRAVENOUS_IMMUNOGLOBULIN_IVIG_AS_AN_ADJUVANT_IN_THE_TREATMENT_OF_NEONATAL_SEPSIS_IN_PRETERM_BABIES_QR_code"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="83750309" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis">Prolonged intravenous immunoglobulin treatment in very low birth weight infants with late onset sepsis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="63989664" href="https://independent.academia.edu/AldoBancalari">Aldo Bancalari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neonatal-Perinatal Medicine, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">BACKGROUND: Neonatal infections are a leading cause of morbi-mortality despite advances in antimicrobials and neonatal care. Preterm infants have greater susceptibility to sepsis due to an immature immune system and lower immunoglobulin levels. Intravenous immunoglobulins (IVIG) have been used in several studies as an adjuvant treatment to improve this physiological immune deficiency, with different outcomes. METHODS: Very low birth weight (VLBW) infants who developed sepsis in the neonatal ICU were studied. They were randomly divided in 2 groups: one group was treated with antibiotics (Group I), and the other received antibiotics plus a 500 mg/kg/day of IVIG during 7 days (Group II). Serum IgG concentration was determined at initiation, during and after treatment Group I, and daily during the 7 days of therapy in Group II. RESULTS: The baseline IgG concentration in group II was 486 g/dL, and increased to 852 mg/dL after the first dose of IVIG (p</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prolonged intravenous immunoglobulin treatment in very low birth weight infants with late onset sepsis","attachmentId":88994346,"attachmentType":"pdf","work_url":"https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="90355451" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis">Role of immunoglobulins in neonatal sepsis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="244473959" href="https://independent.academia.edu/FEDERICAIZZO10">FEDERICA IZZO</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Translational Medicine @ UniSa, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Neonates, especially VLBW, are at high risk for sepsis related morbidity and mortality for immaturity of their immune system and invasive NICU practices. The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune system contributes to their high risk for systemic infection. The use of intravenous IgM enriched immunoglobulins, with higher antimicrobial activity than standard IgG, has been demonstrated in a retrospective study to reduce short term mortality in VLBW infant with proven sepsis. Larger, randomized prospective trials given the enormous burden of morbidity and mortality imposed by neonatal sepsis should urgently be addressed not only to validate this results but also to tailor the optimal scheme of treatment.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of immunoglobulins in neonatal sepsis","attachmentId":93940870,"attachmentType":"pdf","work_url":"https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="1302750" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/1302750/Role_of_Intravenous_Immunoglobulin_IVIG_as_an_Adjuvant_in_the_Treatment_of_Neonatal_Sepsis_in_Preterm_Babies">Role of Intravenous Immunoglobulin (IVIG) as an Adjuvant in the Treatment of Neonatal Sepsis in Preterm Babies.</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="417781" href="https://dhakashishuhospital.academia.edu/NawhadAhmed">Nawshad Ahmed</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="65177755" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/65177755/Intravenous_Immunoglobulin_in_Neonates_Current_Perspective">Intravenous Immunoglobulin in Neonates: Current Perspective</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="205231850" href="https://independent.academia.edu/ChandranRabindran">Rabindran Chandran</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatric Review: International Journal of Pediatric Research</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intravenous Immunoglobulin in Neonates: Current Perspective","attachmentId":76888372,"attachmentType":"pdf","work_url":"https://www.academia.edu/65177755/Intravenous_Immunoglobulin_in_Neonates_Current_Perspective","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/65177755/Intravenous_Immunoglobulin_in_Neonates_Current_Perspective"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="18323843" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18323843/Preterm_infants_with_low_immunoglobulin_G_levels_have_increased_risk_of_neonatal_sepsis_but_do_not_benefit_from_prophylactic_immunoglobulin_G">Preterm infants with low immunoglobulin G levels have increased risk of neonatal sepsis but do not benefit from prophylactic immunoglobulin G</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40422752" href="https://independent.academia.edu/MarthaEibl">Martha Eibl</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38316079" href="https://meduniwien.academia.edu/AngelikaBerger">Angelika Berger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Pediatrics, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Preterm infants with low immunoglobulin G levels have increased risk of neonatal sepsis but do not benefit from prophylactic immunoglobulin G","attachmentId":39995097,"attachmentType":"pdf","work_url":"https://www.academia.edu/18323843/Preterm_infants_with_low_immunoglobulin_G_levels_have_increased_risk_of_neonatal_sepsis_but_do_not_benefit_from_prophylactic_immunoglobulin_G","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18323843/Preterm_infants_with_low_immunoglobulin_G_levels_have_increased_risk_of_neonatal_sepsis_but_do_not_benefit_from_prophylactic_immunoglobulin_G"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div 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data-entity-id="55537942" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55537942/Neonatal_sepsis_Pathogenesis_and_supportive_therapy">Neonatal sepsis: Pathogenesis and supportive therapy</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="139155631" href="https://independent.academia.edu/BaruchWolach">Baruch Wolach</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Seminars in Perinatology, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal sepsis: Pathogenesis and supportive 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class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="192147552" href="https://independent.academia.edu/gokhanceylan">gokhan ceylan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Dr Behcet Uz Children s Hospital</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Assessment of Intravenous Immunoglobulin Indications in Pediatric Intensive Care","attachmentId":108651055,"attachmentType":"pdf","work_url":"https://www.academia.edu/111012375/Assessment_of_Intravenous_Immunoglobulin_Indications_in_Pediatric_Intensive_Care","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link 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href="https://independent.academia.edu/MarciaRench">Marcia Rench</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Pediatrics, 1988</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Disposition of an immunoglobulin intravenous preparation in very low birth weight neonates","attachmentId":66990400,"attachmentType":"pdf","work_url":"https://www.academia.edu/48310388/Disposition_of_an_immunoglobulin_intravenous_preparation_in_very_low_birth_weight_neonates","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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