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window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":48310388,"created_at":"2021-05-04T13:09:43.466-07:00","from_world_paper_id":169561030,"updated_at":"2024-11-23T06:48:21.075-08:00","_data":{"publisher":"Elsevier BV","grobid_abstract":"To assess the disposition, tolerance, and toxicity of an intravenous preparation of immunoglobulin (IGIV) in very low birth weight (VLBW) neonates, we administered single doses of 500 or 750 mg/kg to 20 neonates with birth weights between 750 and 1500 g during the first week of life. The infusion of this product was well tolerated. Modest changes in hemoglobin, hematocrit, and total hemolytic complement occurred as expected. Hepatic toxic effects were not detected. Mean peak IgG concentrations were 1564 and 1316 mg/dL for the high-dose and low-dose groups, respectively. Mean IgG concentrations were very similar for both groups on postinfusion days I, 4, 7, 14, 21, and 28. IgG concentrations remained above 300 mg/dL in seven of 10 infants in each group by day 21, and in six of the high-dose group and seven of the low-dose group by day 28. Mean elimination half-lives were 22.6 and 22.8 days in the high-dose and low-dose groups, respectively. These data provide a basis for assessment of potential efficacy of IGIV in the prevention of late-onset infection in VLBW neonates.","publication_date":"1988,,","publication_name":"The Journal of Pediatrics","grobid_abstract_attachment_id":"66990400"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Disposition of an immunoglobulin intravenous preparation in very low birth weight neonates","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [52654958]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div 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href="https://independent.academia.edu/CostantinoDeGiacomo">Costantino De Giacomo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives de Pédiatrie, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"L’administration d’immunoglobulines intraveineuses n’est pas sans risque durant la période néonatale","attachmentId":68699995,"attachmentType":"pdf","work_url":"https://www.academia.edu/50832753/L_administration_d_immunoglobulines_intraveineuses_n_est_pas_sans_risque_durant_la_p%C3%A9riode_n%C3%A9onatale","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/50832753/L_administration_d_immunoglobulines_intraveineuses_n_est_pas_sans_risque_durant_la_p%C3%A9riode_n%C3%A9onatale"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="15913476" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15913476/Phannacokinetics_of_Intravenous_Immunoglobulin_in_Neonates">Phannacokinetics of Intravenous Immunoglobulin in Neonates</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35069596" href="https://independent.academia.edu/ValHemming">Val Hemming</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vox Sanguinis, 1989</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Phannacokinetics of Intravenous Immunoglobulin in Neonates","attachmentId":42827189,"attachmentType":"pdf","work_url":"https://www.academia.edu/15913476/Phannacokinetics_of_Intravenous_Immunoglobulin_in_Neonates","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15913476/Phannacokinetics_of_Intravenous_Immunoglobulin_in_Neonates"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="83750309" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis">Prolonged intravenous immunoglobulin treatment in very low birth weight infants with late onset sepsis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="63989664" href="https://independent.academia.edu/AldoBancalari">Aldo Bancalari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neonatal-Perinatal Medicine, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">BACKGROUND: Neonatal infections are a leading cause of morbi-mortality despite advances in antimicrobials and neonatal care. Preterm infants have greater susceptibility to sepsis due to an immature immune system and lower immunoglobulin levels. Intravenous immunoglobulins (IVIG) have been used in several studies as an adjuvant treatment to improve this physiological immune deficiency, with different outcomes. METHODS: Very low birth weight (VLBW) infants who developed sepsis in the neonatal ICU were studied. They were randomly divided in 2 groups: one group was treated with antibiotics (Group I), and the other received antibiotics plus a 500 mg/kg/day of IVIG during 7 days (Group II). Serum IgG concentration was determined at initiation, during and after treatment Group I, and daily during the 7 days of therapy in Group II. RESULTS: The baseline IgG concentration in group II was 486 g/dL, and increased to 852 mg/dL after the first dose of IVIG (p</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prolonged intravenous immunoglobulin treatment in very low birth weight infants with late onset sepsis","attachmentId":88994346,"attachmentType":"pdf","work_url":"https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="78303241" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/78303241/Clinical_usage_of_intravenous_immunoglobulin_in_neonates_in_a_tertiary_care_centre_a_retrospective_observational_study">Clinical usage of intravenous immunoglobulin in neonates in a tertiary care centre: a retrospective observational study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="9031392" href="https://independent.academia.edu/BADREDDINEBOUSBIA">BADREDDINE BOUSBIA</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Contemporary Pediatrics, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Intravenous Immunoglobulin (IVIG) is a blood product manufactured from pooled plasma. With increasing availability, an increased usage in neonates is being noted, though its utilisation has not been audited thoroughly. The objectives of this study are to describe the usage pattern and indications of IVIG and its outcome in a state-run tertiary care NICU.Methods: This retrospective observational study was carried out at the inborn unit of Department of Neonatology, Madras Medical College, Chennai on a cohort of neonates who received IVIG over 3.5 years from January 2016 to June 2019. Data was collected from drug register, neonatal case records, exchange transfusion register and death register.Results: Our study cohort had 55 neonates who received IVIG over 3.5 years. Indications for IVIG usage were Rh-alloimmunisation (23), ABO-alloimmunisation (7), prophylaxis of perinatal varicella (20), and other immune thrombocytopenia (5). Among 30 neonates with ABO-/Rh-incompatibili...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Clinical usage of intravenous immunoglobulin in neonates in a tertiary care centre: a retrospective observational study","attachmentId":85397721,"attachmentType":"pdf","work_url":"https://www.academia.edu/78303241/Clinical_usage_of_intravenous_immunoglobulin_in_neonates_in_a_tertiary_care_centre_a_retrospective_observational_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/78303241/Clinical_usage_of_intravenous_immunoglobulin_in_neonates_in_a_tertiary_care_centre_a_retrospective_observational_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="49461969" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/49461969/A_randomized_double_blind_placebo_controlled_investigation_of_the_safety_of_intravenous_immune_globulin_administration_to_preterm_neonates">A randomized, double-blind, placebo-controlled investigation of the safety of intravenous immune globulin administration to preterm neonates</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="22308311" href="https://modares.academia.edu/SajadNoorian">Sajad Noorian</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of perinatology : official journal of the California Perinatal Association, 1989</p><p class="ds-related-work--abstract ds2-5-body-sm">Intravenous immune globulin (750 mg/kg), or an equivalent volume of a placebo, was administered during the first week of life, in a randomized trial, to 20 preterm neonates weighing 710 to 1800 g. A variety of laboratory and clinical values were measured serially and analyzed for possible untoward effects. Serum IgG levels were also determined serially. No differences in heart rate, respiratory rate, urine output, blood glucose, serum osmolality, BUN, SGPT, pH, blood gasses, serum electrolytes, total or direct bilirubin, blood leukocyte concentration, absolute neutrophil count, or blood platelet concentration were observed between the intravenous immune globulin (IVIG) and placebo recipients before or following IVIG administration. The red blood cell concentration of IVIG recipients diminished transiently and only slightly (P less than .05). Serum IgG levels increased from 503 +/- 162 mg/dL (X +/- SD) to 1492 +/- 201 mg/dL 15 minutes after the IVIG administration (P less than .001)....</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A randomized, double-blind, placebo-controlled investigation of the safety of intravenous immune globulin administration to preterm neonates","attachmentId":67807802,"attachmentType":"pdf","work_url":"https://www.academia.edu/49461969/A_randomized_double_blind_placebo_controlled_investigation_of_the_safety_of_intravenous_immune_globulin_administration_to_preterm_neonates","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/49461969/A_randomized_double_blind_placebo_controlled_investigation_of_the_safety_of_intravenous_immune_globulin_administration_to_preterm_neonates"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="105560716" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105560716/Current_status_of_intravenous_immunoglobuiin_in_preventing_or_treating_neonatal_bacterial_infections">Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36158955" href="https://independent.academia.edu/LeonardWeisman">Leonard Weisman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Reviews in Allergy, 1992</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections","attachmentId":104980295,"attachmentType":"pdf","work_url":"https://www.academia.edu/105560716/Current_status_of_intravenous_immunoglobuiin_in_preventing_or_treating_neonatal_bacterial_infections","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/105560716/Current_status_of_intravenous_immunoglobuiin_in_preventing_or_treating_neonatal_bacterial_infections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":66990400,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":66990400,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_66990400" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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href="https://www.academia.edu/18323843/Preterm_infants_with_low_immunoglobulin_G_levels_have_increased_risk_of_neonatal_sepsis_but_do_not_benefit_from_prophylactic_immunoglobulin_G"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="31871982" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31871982/Intravenous_immunoglobulin_for_prophylaxis_of_neonatal_sepsis_in_premature_infants">Intravenous immunoglobulin for prophylaxis of neonatal sepsis in premature infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="61544757" href="https://independent.academia.edu/MariaPastore5">Maria Pastore</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Disease in Childhood, 1988</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intravenous immunoglobulin for prophylaxis of neonatal sepsis in premature infants","attachmentId":52159805,"attachmentType":"pdf","work_url":"https://www.academia.edu/31871982/Intravenous_immunoglobulin_for_prophylaxis_of_neonatal_sepsis_in_premature_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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class="ds-related-work--metadata ds2-5-body-xs">Acta Paediatrica, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"High-dose intravenous immunoglobulin therapy in neonatal immune haemolytic jaundice","attachmentId":105937688,"attachmentType":"pdf","work_url":"https://www.academia.edu/107197053/High_dose_intravenous_immunoglobulin_therapy_in_neonatal_immune_haemolytic_jaundice","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/107197053/High_dose_intravenous_immunoglobulin_therapy_in_neonatal_immune_haemolytic_jaundice"><span class="ds2-5-text-link__content">View PDF</span><span 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data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intravenous Immunoglobulin in Neonatal Sepsis","attachmentId":99792213,"attachmentType":"pdf","work_url":"https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="110671809" data-sort-order="default"><a class="ds-related-work--title 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