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(PDF) Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections
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Since newborn babies acquire immunoglobulin (IgG) transplacentally from their mothers in the latter part of gestation, premature infants (\u003c32-34 Wk gestation) have decreased levels of serum IgG (1,2). The antibodies acquired transplacentally are also limited to the mother's previous exposure to specific pathogens~ Therefore, newborns (especially preterms) may have both a qualitative and quantitative immunoglobulin deficiency. Opsonic antibody is important for immunity against bacteria with polysaccharide capsules (Streptococcus agalactiae, Streptococcus pneumoniae, HemophiIus influenzae, Escherichia coli) and intravenous Lmmunoglobulin (MG) has been shown to contain opsonic antibody for several of these bacterial pathogens (3, 6). Several studies over the last 25 yr in newborn babies have suggested that immunoglobulin therapy might enhance neonatal immunity against bacterial pathogens. In 1963 immune serum globulin (ISG) was given intramuscularly every 4 wk to premature infants and resulted in fewer manor il~esses (7). However, it was Concluded","publication_date":"1992,,","publication_name":"Clinical Reviews in Allergy","grobid_abstract_attachment_id":"104980295"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [36158955]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card ds-work-card--no-bottom-spacing"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":104980295,"attachmentType":"pdf"}"><img alt="First page of “Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/104980295/mini_magick20230814-1-khrnv7.png?1691979784" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="36158955" href="https://independent.academia.edu/LeonardWeisman"><img alt="Profile image of Leonard Weisman" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Leonard Weisman</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">1992, Clinical Reviews in Allergy</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">16 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 105560716; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=105560716"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Bacterial infections continue to be an important problem for neonates throughout the world. Since newborn babies acquire immunoglobulin (IgG) transplacentally from their mothers in the latter part of gestation, premature infants (<32-34 Wk gestation) have decreased levels of serum IgG (1,2). The antibodies acquired transplacentally are also limited to the mother's previous exposure to specific pathogens~ Therefore, newborns (especially preterms) may have both a qualitative and quantitative immunoglobulin deficiency. Opsonic antibody is important for immunity against bacteria with polysaccharide capsules (Streptococcus agalactiae, Streptococcus pneumoniae, HemophiIus influenzae, Escherichia coli) and intravenous Lmmunoglobulin (MG) has been shown to contain opsonic antibody for several of these bacterial pathogens (3, 6). Several studies over the last 25 yr in newborn babies have suggested that immunoglobulin therapy might enhance neonatal immunity against bacterial pathogens. In 1963 immune serum globulin (ISG) was given intramuscularly every 4 wk to premature infants and resulted in fewer manor il~esses (7). However, it was Concluded</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":104980295,"attachmentType":"pdf","workUrl":"https://www.academia.edu/105560716/Current_status_of_intravenous_immunoglobuiin_in_preventing_or_treating_neonatal_bacterial_infections"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":104980295,"attachmentType":"pdf","workUrl":"https://www.academia.edu/105560716/Current_status_of_intravenous_immunoglobuiin_in_preventing_or_treating_neonatal_bacterial_infections"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/18323843/Preterm_infants_with_low_immunoglobulin_G_levels_have_increased_risk_of_neonatal_sepsis_but_do_not_benefit_from_prophylactic_immunoglobulin_G"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="15913476" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15913476/Phannacokinetics_of_Intravenous_Immunoglobulin_in_Neonates">Phannacokinetics of Intravenous Immunoglobulin in 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href="https://www.academia.edu/15913476/Phannacokinetics_of_Intravenous_Immunoglobulin_in_Neonates"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="31871982" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31871982/Intravenous_immunoglobulin_for_prophylaxis_of_neonatal_sepsis_in_premature_infants">Intravenous immunoglobulin for prophylaxis of neonatal sepsis in premature infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="61544757" href="https://independent.academia.edu/MariaPastore5">Maria Pastore</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives 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href="https://www.academia.edu/30523496/Immunoglobulin_secretion_by_the_normal_and_the_infected_newborn_infant"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="93255343" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93255343/A_Study_to_Assess_the_Importance_of_Intravenous_Immunoglobulin_Ivig_as_an_Adjuvant_in_the_Treatment_of_Neonatal_Sepsis_in_Preterm_Babies">A Study to Assess the Importance of Intravenous Immunoglobulin (Ivig) as an Adjuvant in the Treatment of Neonatal Sepsis in Preterm Babies</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="250465137" 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href="https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="16" data-entity-id="27621195" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27621195/Directed_immune_globulin_for_the_prevention_or_treatment_of_neonatal_group_B_streptococcal_infections_A_review">Directed immune globulin for the prevention or treatment of neonatal group B streptococcal infections: A review</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35069596" 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