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(PDF) prevention and GUIDELINES ON control of chemical hazard | Rohan Mehta - Academia.edu

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data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Occupational exposure limits for cumene, 2,4‐dichlorophenoxy acetic acid, silicon carbide whisker, benzyl alcohol, and methylamine, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications&quot;,&quot;attachmentId&quot;:110738761,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/113896950/Occupational_exposure_limits_for_cumene_2_4_dichlorophenoxy_acetic_acid_silicon_carbide_whisker_benzyl_alcohol_and_methylamine_and_carcinogenicity_occupational_sensitizer_and_reproductive_toxicant_classifications&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/113896950/Occupational_exposure_limits_for_cumene_2_4_dichlorophenoxy_acetic_acid_silicon_carbide_whisker_benzyl_alcohol_and_methylamine_and_carcinogenicity_occupational_sensitizer_and_reproductive_toxicant_classifications"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="19372674" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19372674/Mixture_effects_of_benzene_toluene_ethylbenzene_and_xylenes_BTEX_on_lung_carcinoma_cells_via_a_hanging_drop_air_exposure_system">Mixture effects of benzene, toluene, ethylbenzene, and xylenes (BTEX) on lung carcinoma cells via a hanging drop air exposure system</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39638814" href="https://independent.academia.edu/FayeLiu1">Faye Liu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chemical research in toxicology, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">A recently developed hanging drop air exposure system for toxicity studies of volatile chemicals was applied to evaluate the cell viability of lung carcinoma A549 cells after 1 and 24 h of exposure to benzene, toluene, ethylbenzene, and xylenes (BTEX) as individual compounds and as mixtures of four or six components. The cellular chemical concentrations causing 50% reduction of cell viability (EC50) were calculated using a mass balance model and came to 17, 12, 11, 9, 4, and 4 mmol/kg cell dry weight for benzene, toluene, ethylbenzene, m-xylene, o-xylene, and p-xylene, respectively, after 1 h of exposure. The EC50 decreased by a factor of 4 after 24 h of exposure. All mixture effects were best described by the mixture toxicity model of concentration addition, which is valid for chemicals with the same mode of action. 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