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La premiere partie montre l&#39;effet" /> <title>(PDF) Etude Des Effets De L'Extrait De Cartilage De Requin et Du TLN-4601 Sur Le Glioblastome Chez La Souris GR ^ Ace Aux Technologies Transcriptomiques et Proteomiques | Bryan Simard - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/94967993/Etude_Des_Effets_De_LExtrait_De_Cartilage_De_Requin_et_Du_TLN_4601_Sur_Le_Glioblastome_Chez_La_Souris_GR_Ace_Aux_Technologies_Transcriptomiques_et_Proteomiques" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732476392000); window.Aedu.timeDifference = new Date().getTime() - 1732476392000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Le glioblastome represente le grade le plus eleve des tumeurs cerebrales. Sa croissance est favorisee par une forte neovascularisation de meme que par l\u0026amp;amp;#39;activation de la voie du recepteur a l\u0026amp;amp;#39;EGFR-Ras. La premiere partie montre l\u0026amp;amp;#39;effet antiangiogenique et antitumoral de l\u0026amp;amp;#39;extrait de cartilage dans plusieurs modeles de glioblastome chez la souris. L\u0026amp;amp;#39;etude du transcriptome des cellules endotheliales a permise de proposer des mecanismes d\u0026amp;amp;#39;actions. Il a ete propose que l\u0026amp;amp;#39;extrait de cartilage induise la secretion de cytokines, qui entrainent la generation de derives reactifs de l\u0026amp;amp;#39;oxygene. Ceux-ci entraineraient l\u0026amp;amp;#39;activation du NFkB qui induirait l\u0026amp;amp;#39;expression d\u0026amp;amp;#39;un premier reseau de genes impliques dans l\u0026amp;amp;#39;inflammation de l\u0026amp;amp;#39;endothelium en croissance. La co-administration de corticoides pour reduire l\u0026amp;amp;#39;œdeme tumoral a d\u0026amp;amp;#39;ailleurs entraine une perte de l\u0026amp;amp;#39;efficacite in vivo et serait donc a proscrire en clinique. L\u0026amp;amp;#39;extrait de ca...","author":[{"@context":"https://schema.org","@type":"Person","name":"Bryan Simard"}],"contributor":[],"dateCreated":"2023-01-14","dateModified":"2023-01-14","datePublished":"2010-01-01","headline":"Etude Des Effets De L'Extrait De Cartilage De Requin et Du TLN-4601 Sur Le Glioblastome Chez La Souris GR ^ Ace Aux Technologies Transcriptomiques et Proteomiques","inLanguage":"en","keywords":["Chemistry","Molecular 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Sa croissance est favorisee par une forte neovascularisation de meme que par l\u0026#39;activation de la voie du recepteur a l\u0026#39;EGFR-Ras. La premiere partie montre l\u0026#39;effet antiangiogenique et antitumoral de l\u0026#39;extrait de cartilage dans plusieurs modeles de glioblastome chez la souris. L\u0026#39;etude du transcriptome des cellules endotheliales a permise de proposer des mecanismes d\u0026#39;actions. Il a ete propose que l\u0026#39;extrait de cartilage induise la secretion de cytokines, qui entrainent la generation de derives reactifs de l\u0026#39;oxygene. Ceux-ci entraineraient l\u0026#39;activation du NFkB qui induirait l\u0026#39;expression d\u0026#39;un premier reseau de genes impliques dans l\u0026#39;inflammation de l\u0026#39;endothelium en croissance. La co-administration de corticoides pour reduire l\u0026#39;œdeme tumoral a d\u0026#39;ailleurs entraine une perte de l\u0026#39;efficacite in vivo et serait donc a proscrire en clinique. L\u0026#39;extrait de ca...","publication_date":"2010,,"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Etude Des Effets De L'Extrait De Cartilage De Requin et Du TLN-4601 Sur Le Glioblastome Chez La Souris GR ^ Ace Aux Technologies Transcriptomiques et Proteomiques","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [16445012]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":97280791,"attachmentType":"pdf"}"><img alt="First page of “Etude Des Effets De L'Extrait De Cartilage De Requin et Du TLN-4601 Sur Le Glioblastome Chez La Souris GR ^ Ace Aux Technologies Transcriptomiques et Proteomiques”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/97280791/mini_magick20230114-1-xoyqyz.png?1673707621" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Etude Des Effets De L'Extrait De Cartilage De Requin et Du TLN-4601 Sur Le Glioblastome Chez La Souris GR ^ Ace Aux Technologies Transcriptomiques et Proteomiques</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="16445012" href="https://nrc-ca.academia.edu/BryanSimard"><img alt="Profile image of Bryan Simard" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Bryan Simard</a></div><p class="ds-work-card--detail ds2-5-body-sm">2010</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Le glioblastome represente le grade le plus eleve des tumeurs cerebrales. Sa croissance est favorisee par une forte neovascularisation de meme que par l&#39;activation de la voie du recepteur a l&#39;EGFR-Ras. La premiere partie montre l&#39;effet antiangiogenique et antitumoral de l&#39;extrait de cartilage dans plusieurs modeles de glioblastome chez la souris. L&#39;etude du transcriptome des cellules endotheliales a permise de proposer des mecanismes d&#39;actions. Il a ete propose que l&#39;extrait de cartilage induise la secretion de cytokines, qui entrainent la generation de derives reactifs de l&#39;oxygene. Ceux-ci entraineraient l&#39;activation du NFkB qui induirait l&#39;expression d&#39;un premier reseau de genes impliques dans l&#39;inflammation de l&#39;endothelium en croissance. La co-administration de corticoides pour reduire l&#39;œdeme tumoral a d&#39;ailleurs entraine une perte de l&#39;efficacite in vivo et serait donc a proscrire en clinique. L&#39;extrait de ca...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":97280791,"attachmentType":"pdf","workUrl":"https://www.academia.edu/94967993/Etude_Des_Effets_De_LExtrait_De_Cartilage_De_Requin_et_Du_TLN_4601_Sur_Le_Glioblastome_Chez_La_Souris_GR_Ace_Aux_Technologies_Transcriptomiques_et_Proteomiques"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":97280791,"attachmentType":"pdf","workUrl":"https://www.academia.edu/94967993/Etude_Des_Effets_De_LExtrait_De_Cartilage_De_Requin_et_Du_TLN_4601_Sur_Le_Glioblastome_Chez_La_Souris_GR_Ace_Aux_Technologies_Transcriptomiques_et_Proteomiques"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="97280791" data-landing_url="https://www.academia.edu/94967993/Etude_Des_Effets_De_LExtrait_De_Cartilage_De_Requin_et_Du_TLN_4601_Sur_Le_Glioblastome_Chez_La_Souris_GR_Ace_Aux_Technologies_Transcriptomiques_et_Proteomiques" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="8285353" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/8285353/Induction_of_the_fibrinolytic_system_by_cartilage_extract_mediates_its_antiangiogenic_effect_in_mouse_glioma">Induction of the fibrinolytic system by cartilage extract mediates its antiangiogenic effect in mouse glioma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="16445012" href="https://nrc-ca.academia.edu/BryanSimard">Bryan Simard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Microvascular Research, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Induction of the fibrinolytic system by cartilage extract mediates its antiangiogenic effect in mouse glioma","attachmentId":48154859,"attachmentType":"pdf","work_url":"https://www.academia.edu/8285353/Induction_of_the_fibrinolytic_system_by_cartilage_extract_mediates_its_antiangiogenic_effect_in_mouse_glioma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/8285353/Induction_of_the_fibrinolytic_system_by_cartilage_extract_mediates_its_antiangiogenic_effect_in_mouse_glioma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="85137534" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85137534/Corticosteroids_compromise_survival_in_glioblastoma">Corticosteroids compromise survival in glioblastoma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47430850" href="https://independent.academia.edu/KathrynBeal">Kathryn Beal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain : a journal of neurology, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Glioblastoma is the most common and most aggressive primary brain tumour. 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