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data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Rolando Maestro</h3></div><div class="js-work-strip profile--work_container" data-work-id="113442391"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442391/The_importance_of_cell_density_in_the_interpretation_of_growth_factor_effects_on_collagenase_IV_activity_release_and_extracellular_matrix_production_from_C6_astrocytoma_cells"><img alt="Research paper thumbnail of The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells" class="work-thumbnail" src="https://attachments.academia-assets.com/110399748/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442391/The_importance_of_cell_density_in_the_interpretation_of_growth_factor_effects_on_collagenase_IV_activity_release_and_extracellular_matrix_production_from_C6_astrocytoma_cells">The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells</a></div><div class="wp-workCard_item"><span>Journal of Neuro-oncology</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have examined the influence of basic fibroblast growth factor (FGF-2) and vascular endothelial...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have examined the influence of basic fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF) on the release of collagenase type IV activity and the production of extracellular matrix (ECM) molecules using C6 astrocytoma cells in monolayer culture. Collagenase type IV activity was significantly increased in a dose dependent manner in the low cell density group by treatment</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="252101d4b0a3b29dfcf3973d6c7e9358" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399748,"asset_id":113442391,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399748/download_file?st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442391"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442391"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442391; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442391]").text(description); $(".js-view-count[data-work-id=113442391]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442391; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442391']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442391, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "252101d4b0a3b29dfcf3973d6c7e9358" } } $('.js-work-strip[data-work-id=113442391]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442391,"title":"The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells","translated_title":"","metadata":{"abstract":"We have examined the influence of basic fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF) on the release of collagenase type IV activity and the production of extracellular matrix (ECM) molecules using C6 astrocytoma cells in monolayer culture. 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113442390"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442390/Effects_of_Surgical_Excision_and_Radiation_on_Medulloblastoma_Cell_Invasiveness"><img alt="Research paper thumbnail of Effects of Surgical Excision and Radiation on Medulloblastoma Cell Invasiveness" class="work-thumbnail" src="https://attachments.academia-assets.com/110399724/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442390/Effects_of_Surgical_Excision_and_Radiation_on_Medulloblastoma_Cell_Invasiveness">Effects of Surgical Excision and Radiation on Medulloblastoma Cell Invasiveness</a></div><div class="wp-workCard_item"><span>Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives:Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patien...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives:Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patient management. We utilized a novel 3-dimensional assay to identify how (a) radiation, (b) excision of the primary tumour aggregate, and (c) both treatments combined influence MB cell invasiveness.Methods:Five MB cell lines (UW228-1, 2 and 3; Daoy, and Madsen) were implanted onto a 3-dimensional, type I collagen gel assay to assess tumour invasion distance over five days, in response to (1) needle-assisted excision of the central cell aggregate; (2) pre-exposure to single-dose and fractionated dose irradiation in doses from 6-25 and 8-24 Gy, respectively; and (3) excision plus either single-dose or fractionated radiation.Results:Within hours, individual MB cells detached from the surface of the cell aggregates and invaded the collagen matrix, to distances up to 1200 μm and at rates up to 300 μm daily. The UW228-1 cell line was less invasive than the other cell lines and was dropped from fu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7c65150f7278961fb4585e9be2073fd8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399724,"asset_id":113442390,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399724/download_file?st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442390"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442390; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442390]").text(description); $(".js-view-count[data-work-id=113442390]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442390; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442390']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442390, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7c65150f7278961fb4585e9be2073fd8" } } $('.js-work-strip[data-work-id=113442390]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442390,"title":"Effects of Surgical Excision and Radiation on Medulloblastoma Cell Invasiveness","translated_title":"","metadata":{"abstract":"Objectives:Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patient management. We utilized a novel 3-dimensional assay to identify how (a) radiation, (b) excision of the primary tumour aggregate, and (c) both treatments combined influence MB cell invasiveness.Methods:Five MB cell lines (UW228-1, 2 and 3; Daoy, and Madsen) were implanted onto a 3-dimensional, type I collagen gel assay to assess tumour invasion distance over five days, in response to (1) needle-assisted excision of the central cell aggregate; (2) pre-exposure to single-dose and fractionated dose irradiation in doses from 6-25 and 8-24 Gy, respectively; and (3) excision plus either single-dose or fractionated radiation.Results:Within hours, individual MB cells detached from the surface of the cell aggregates and invaded the collagen matrix, to distances up to 1200 μm and at rates up to 300 μm daily. The UW228-1 cell line was less invasive than the other cell lines and was dropped from fu...","publisher":"Cambridge University Press (CUP)","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques"},"translated_abstract":"Objectives:Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patient management. We utilized a novel 3-dimensional assay to identify how (a) radiation, (b) excision of the primary tumour aggregate, and (c) both treatments combined influence MB cell invasiveness.Methods:Five MB cell lines (UW228-1, 2 and 3; Daoy, and Madsen) were implanted onto a 3-dimensional, type I collagen gel assay to assess tumour invasion distance over five days, in response to (1) needle-assisted excision of the central cell aggregate; (2) pre-exposure to single-dose and fractionated dose irradiation in doses from 6-25 and 8-24 Gy, respectively; and (3) excision plus either single-dose or fractionated radiation.Results:Within hours, individual MB cells detached from the surface of the cell aggregates and invaded the collagen matrix, to distances up to 1200 μm and at rates up to 300 μm daily. The UW228-1 cell line was less invasive than the other cell lines and was dropped from 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href="https://www.academia.edu/113442389/Pineal_Apoplexy_Imaging_Diagnosis_and_Follow_up_of_Three_New_Cases"><img alt="Research paper thumbnail of Pineal Apoplexy: Imaging Diagnosis and Follow-up of Three New Cases" class="work-thumbnail" src="https://attachments.academia-assets.com/110399743/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442389/Pineal_Apoplexy_Imaging_Diagnosis_and_Follow_up_of_Three_New_Cases">Pineal Apoplexy: Imaging Diagnosis and Follow-up of Three New Cases</a></div><div class="wp-workCard_item"><span>The Canadian Journal of Neurological Sciences</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cabb5417833c2a3a6029f85256ada267" class="wp-workCard--action" 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442389]").text(description); $(".js-view-count[data-work-id=113442389]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442389; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442389']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442389, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cabb5417833c2a3a6029f85256ada267" } } $('.js-work-strip[data-work-id=113442389]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442389,"title":"Pineal Apoplexy: Imaging Diagnosis and Follow-up of Three New Cases","translated_title":"","metadata":{"publisher":"Cambridge University Press (CUP)","grobid_abstract":"Cystic lesions on the pineal gland are a common phenomenon, being found on up to 40% of autopsy cases 1. However, symptomatology as a result of these cysts is considerably rare. Mukherjee, Banerji and Sharma identified 74 cases in the literature 1. Symptomatic pineal cysts present as one of three syndromes identified by Wisoff and Epstein 2 : (1) paroxysmal headache with gaze paresis, (2) chronic headache, gaze paresis, papilledema and hydrocephalus, and (3) pineal apoplexy with acute hydrocephalus. Pineal apoplexy is understood as an acute presentation of hemorrhage within a pineal cystic lesion. Of the three syndromes pineal apoplexy is the rarest and while poorly understood, can have the most catastrophic of consequences, resulting in sudden death 3. Herein we report three cases with clinical and imaging findings suggestive of pineal gland apoplexy in the context of a discussion of the relevant literature.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"The Canadian Journal of Neurological Sciences","grobid_abstract_attachment_id":110399743},"translated_abstract":null,"internal_url":"https://www.academia.edu/113442389/Pineal_Apoplexy_Imaging_Diagnosis_and_Follow_up_of_Three_New_Cases","translated_internal_url":"","created_at":"2024-01-13T11:57:24.522-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110399743,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399743/thumbnails/1.jpg","file_name":"div-class-title-pineal-apoplexy-imaging-diagnosis-and-follow-up-of-three-new-cases-div.pdf","download_url":"https://www.academia.edu/attachments/110399743/download_file?st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Pineal_Apoplexy_Imaging_Diagnosis_and_Fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399743/div-class-title-pineal-apoplexy-imaging-diagnosis-and-follow-up-of-three-new-cases-div-libre.pdf?1705176154=\u0026response-content-disposition=attachment%3B+filename%3DPineal_Apoplexy_Imaging_Diagnosis_and_Fo.pdf\u0026Expires=1732807501\u0026Signature=aXtCUlN~sh74RUxx2K4zJmba6~yRybn4lH30XI7cXd501teER5seajDvlW8Ug-7BB9kZQfHiDn0aEmsrmlVQkLZZuvUuwbo30HzoplGzEPZy-5JxFDrBc48KsPzaSHlmZWkvzVzYI9Pqqc3m713hJw1jusxr9ABAKcOF9SFY6Ycldtc8xe1t6pw0~2TyI8KGKLetM~7bEwO6TlXV5~v9GZbU6USPXkmE1TghKSYZsTAHFQooLmyTDEm5rvV0z~bEVFpd~048Pr2a0~6YfFru41oST02paJ0L9gIkYhPR533j4Pmhy-4keUjnvswlyLIhdIx0o8zbKHmX88fATxco3A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Pineal_Apoplexy_Imaging_Diagnosis_and_Follow_up_of_Three_New_Cases","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":110399743,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399743/thumbnails/1.jpg","file_name":"div-class-title-pineal-apoplexy-imaging-diagnosis-and-follow-up-of-three-new-cases-div.pdf","download_url":"https://www.academia.edu/attachments/110399743/download_file?st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Pineal_Apoplexy_Imaging_Diagnosis_and_Fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399743/div-class-title-pineal-apoplexy-imaging-diagnosis-and-follow-up-of-three-new-cases-div-libre.pdf?1705176154=\u0026response-content-disposition=attachment%3B+filename%3DPineal_Apoplexy_Imaging_Diagnosis_and_Fo.pdf\u0026Expires=1732807501\u0026Signature=aXtCUlN~sh74RUxx2K4zJmba6~yRybn4lH30XI7cXd501teER5seajDvlW8Ug-7BB9kZQfHiDn0aEmsrmlVQkLZZuvUuwbo30HzoplGzEPZy-5JxFDrBc48KsPzaSHlmZWkvzVzYI9Pqqc3m713hJw1jusxr9ABAKcOF9SFY6Ycldtc8xe1t6pw0~2TyI8KGKLetM~7bEwO6TlXV5~v9GZbU6USPXkmE1TghKSYZsTAHFQooLmyTDEm5rvV0z~bEVFpd~048Pr2a0~6YfFru41oST02paJ0L9gIkYhPR533j4Pmhy-4keUjnvswlyLIhdIx0o8zbKHmX88fATxco3A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":293670,"name":"Pituitary Gland","url":"https://www.academia.edu/Documents/in/Pituitary_Gland"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113442388"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442388/Effect_of_ibuprofen_on_tumor_growth_in_the_C6_spheroid_implantation_glioma_model"><img alt="Research paper thumbnail of Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442388/Effect_of_ibuprofen_on_tumor_growth_in_the_C6_spheroid_implantation_glioma_model">Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model</a></div><div class="wp-workCard_item"><span>Journal of Neurosurgery</span><span>, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">✓ The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were ass...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">✓ The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats. The rats were treated with ibuprofen (24 mg/kg/day or 96 mg/kg/day) for 24 hours before implantation of C6 astrocytoma spheroids and then for 13 days following implantation. The wet and dry weight of the tumors and protein extravasation were measured by an Evans blue dye technique. Protein extravasation did not appear to be reduced by the treatments when assessed on the basis of tumor dry weight. The treatment significantly reduced the wet weight of the tumors in rats treated with high-dose and low-dose ibuprofen when compared to tumor wet weights in untreated rats. High-dose ibuprofen treatment significantly decreased the dry weight of the tumors compared to that of tumors in untreated control animals. It is hypothesized that the ibuprofen treatment regimen employed inhibits prostaglandin-associated angiogenesis induced by the C6 tumor cell growth and/or...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442388"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442388"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442388; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442388]").text(description); $(".js-view-count[data-work-id=113442388]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442388; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442388']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442388, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113442388]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442388,"title":"Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model","translated_title":"","metadata":{"abstract":"✓ The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats. The rats were treated with ibuprofen (24 mg/kg/day or 96 mg/kg/day) for 24 hours before implantation of C6 astrocytoma spheroids and then for 13 days following implantation. The wet and dry weight of the tumors and protein extravasation were measured by an Evans blue dye technique. Protein extravasation did not appear to be reduced by the treatments when assessed on the basis of tumor dry weight. The treatment significantly reduced the wet weight of the tumors in rats treated with high-dose and low-dose ibuprofen when compared to tumor wet weights in untreated rats. High-dose ibuprofen treatment significantly decreased the dry weight of the tumors compared to that of tumors in untreated control animals. 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The treatment significantly reduced the wet weight of the tumors in rats treated with high-dose and low-dose ibuprofen when compared to tumor wet weights in untreated rats. High-dose ibuprofen treatment significantly decreased the dry weight of the tumors compared to that of tumors in untreated control animals. It is hypothesized that the ibuprofen treatment regimen employed inhibits prostaglandin-associated angiogenesis induced by the C6 tumor cell growth and/or...","internal_url":"https://www.academia.edu/113442388/Effect_of_ibuprofen_on_tumor_growth_in_the_C6_spheroid_implantation_glioma_model","translated_internal_url":"","created_at":"2024-01-13T11:57:24.310-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_ibuprofen_on_tumor_growth_in_the_C6_spheroid_implantation_glioma_model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[],"research_interests":[{"id":650,"name":"Neurosurgery","url":"https://www.academia.edu/Documents/in/Neurosurgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38650,"name":"Cell Division","url":"https://www.academia.edu/Documents/in/Cell_Division"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":83972,"name":"Permeability","url":"https://www.academia.edu/Documents/in/Permeability"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":284339,"name":"Ibuprofen","url":"https://www.academia.edu/Documents/in/Ibuprofen"},{"id":1178162,"name":"Tumor Growth","url":"https://www.academia.edu/Documents/in/Tumor_Growth"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":3693750,"name":"Extravasation","url":"https://www.academia.edu/Documents/in/Extravasation"}],"urls":[{"id":38532193,"url":"https://thejns.org/downloadpdf/journals/j-neurosurg/68/6/article-p925.xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113442387"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442387/Effects_of_steroids_and_nonsteroid_anti_inflammatory_agents_on_vascular_permeability_in_a_rat_glioma_model"><img alt="Research paper thumbnail of Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model" class="work-thumbnail" src="https://attachments.academia-assets.com/110399744/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442387/Effects_of_steroids_and_nonsteroid_anti_inflammatory_agents_on_vascular_permeability_in_a_rat_glioma_model">Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model</a></div><div class="wp-workCard_item"><span>Journal of Neurosurgery</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">✓ Cerebral edema produced by brain tumors is clinically and experimentally reduced by steroid the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">✓ Cerebral edema produced by brain tumors is clinically and experimentally reduced by steroid therapy. Nonsteroid anti-inflammatory drugs (NSAID&#39;s) which have been used to treat non-neural inflammation and swelling have not been evaluated for their ability to affect edema produced by brain tumors. The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID&#39;s (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas. Evans blue dye was used as a marker for serum albumin extravasation. The concentration of Evans blue dye was measured in the tumor and peritumoral and contralateral brain tissue 1 hour after intravenous injection. Extravasation of Evans blue dye within the tumor was decreased in all treatment groups when compared to placebo-injected control animals. The differences between the control specimens and those treated with dexamethasone, methyl...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e36462010554d569e2345530a45e57eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399744,"asset_id":113442387,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399744/download_file?st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442387"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442387"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442387; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442387]").text(description); $(".js-view-count[data-work-id=113442387]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442387; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442387']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442387, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e36462010554d569e2345530a45e57eb" } } $('.js-work-strip[data-work-id=113442387]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442387,"title":"Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model","translated_title":"","metadata":{"abstract":"✓ Cerebral edema produced by brain tumors is clinically and experimentally reduced by steroid therapy. Nonsteroid anti-inflammatory drugs (NSAID\u0026#39;s) which have been used to treat non-neural inflammation and swelling have not been evaluated for their ability to affect edema produced by brain tumors. The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID\u0026#39;s (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas. Evans blue dye was used as a marker for serum albumin extravasation. The concentration of Evans blue dye was measured in the tumor and peritumoral and contralateral brain tissue 1 hour after intravenous injection. Extravasation of Evans blue dye within the tumor was decreased in all treatment groups when compared to placebo-injected control animals. 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442386/A_new_glioma_model_in_rat_The_C6_spheroid_implantation_technique_permeability_and_vascular_characterization"><img alt="Research paper thumbnail of A new glioma model in rat: The C6 spheroid implantation technique permeability and vascular characterization" class="work-thumbnail" src="https://attachments.academia-assets.com/110399752/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442386/A_new_glioma_model_in_rat_The_C6_spheroid_implantation_technique_permeability_and_vascular_characterization">A new glioma model in rat: The C6 spheroid implantation technique permeability and vascular characterization</a></div><div class="wp-workCard_item"><span>Journal of Neuro-Oncology</span><span>, 1987</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="64c81eb60b69567afd05fb9b23d398ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399752,"asset_id":113442386,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399752/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442386"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div 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{"id":113442386,"title":"A new glioma model in rat: The C6 spheroid implantation technique permeability and vascular characterization","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"The C6 spheroid implantation glioma model is a simple, easily reproduced model for primary gliomas in which C6 astrocytoma cells are grown in vitro as spheroids and subsequently implanted into the brains of Sprague Dawley rat hosts. This report describes the growth, histology, vessel architecture and vascular permeability of the resulting tumors. The appearance of the tumor was investigated by light and electron microscopy, and by using the alkaline phosphatase technique. The leakage of tracer was measured from vessels in the tumor and peritumoral area at various times during tumor development. The spheroid implant produces a fully vascularized, rapidly growing tumor with many of the characteristics of glioblastoma multiforme, from an avascular focus of neoplastic cells. The major advantage of this model is that the tumors grow in a spheroidal fashion and the tumor-brain interface can be easily located. Many of the important events in the process of vascularization take place at the tumor-brain interface. Two distinctive vascular events appear to occur simultaneously: 1) proliferation of blood vessels and their growth into the tumor mass so that they develop into typical, permeable tumor vessels, and 2) migration of tumor cells along normal vessels into the surrounding brain. Tumor vessels were permeable to the tracer Evans Blue (EB) from the earliest days of ingrowth. Leakage of the EB increased as the tumors increased in size, but eventually leakage plateaued as tumors developed necrotic centers. It is well known that the structural and permeability characteristics of vessels associated with the tumor affect tumor growth. This model will be useful for a number of proposed studies including assessment of various clinical therapies on tumor growth and development, and more specifically, quantitative analysis of the vascularization process in tumors.","publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"Journal of 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data-work-id="113442385"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442385/Accelerated_Hypofractionated_Intensity_Modulated_Radiotherapy_With_Concurrent_and_Adjuvant_Temozolomide_for_Patients_With_Glioblastoma_Multiforme_A_Safety_and_Efficacy_Analysis"><img alt="Research paper thumbnail of Accelerated Hypofractionated Intensity-Modulated Radiotherapy With Concurrent and Adjuvant Temozolomide for Patients With Glioblastoma Multiforme: A Safety and Efficacy Analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/110399749/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442385/Accelerated_Hypofractionated_Intensity_Modulated_Radiotherapy_With_Concurrent_and_Adjuvant_Temozolomide_for_Patients_With_Glioblastoma_Multiforme_A_Safety_and_Efficacy_Analysis">Accelerated Hypofractionated Intensity-Modulated Radiotherapy With Concurrent and Adjuvant Temozolomide for Patients With Glioblastoma Multiforme: A Safety and Efficacy Analysis</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Oncology*Biology*Physics</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ed7d84ae3443d97828f92655194662cc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399749,"asset_id":113442385,"asset_type":"Work","button_location":"profile"}" 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ed7d84ae3443d97828f92655194662cc" } } $('.js-work-strip[data-work-id=113442385]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442385,"title":"Accelerated Hypofractionated Intensity-Modulated Radiotherapy With Concurrent and Adjuvant Temozolomide for Patients With Glioblastoma Multiforme: A Safety and Efficacy Analysis","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"6 mg/m 2 q3wk cohort, and one DLT (pneumonia/infection without neutropenia) in six patients treated at 8 mg/m 2 q3wk. In the subsequent dose level (10 mg/m 2 q3wk), two DLT's occurred among four treated patients: one patient with renal failure and one patient with fatal pulmonary hemorrhage (the latter DLT was probably more likely related to underlying tumor than study treatment but a possible relationship can not be ruled out). It was decided to consider 8 mg/m 2 q3wk the MTD and future recommended phase II dose. Two patients (out of four evaluable patients) in this dose level had partial responses. Conclusions: With palliative fractionated brain radiotherapy (minimum 37.5 Gy), concurrent patupilone can be given at 8 mg/m 2 q3wk; this regimen is feasible for Phase II study.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"International Journal of Radiation 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442384/A_quantitative_study_of_blood_brain_barrier_permeability_ultrastructure_in_a_new_rat_glioma_model">A quantitative study of blood-brain barrier permeability ultrastructure in a new rat glioma model</a></div><div class="wp-workCard_item"><span>Acta Neuropathologica</span><span>, 1985</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd0d13f7d77f3b40dcdcc203c9a56b10" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399742,"asset_id":113442384,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399742/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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the blood-brain barrier (B-BB). The vascular ultrastructural changes that underlie edema formation have been described in a variety of tumors. Interendothelial junction abnormalities, fenestrations, and large numbers of tubulo-vesicular profiles in the tumor vascular endothelium have been presumed to represent permeability routes that permit the escape of serum constituents into the tumor, from where they flow into the surrounding brain. Descriptive studies do not provide information on the relative frequency of these presumptive permeability routes. In the study reported here we have quantified ultrastructural features associated with the B-BB in the vessels of an experimental glioma in rat. We found that approximately 60% of the tumor vessel profiles have junctional abnormalities and 30% have one or more fenestrations. The density of tubulo-vesicular profiles, however, was not increased. In addition, tumor vessel walls were thicker than normal vessels of the same caliber and the mitochondrial density was in the range of that for non-barrier vessels. Vessels in peritumoral regions were not altered in any of the parameters measured.","publication_date":{"day":null,"month":null,"year":1985,"errors":{}},"publication_name":"Acta Neuropathologica","grobid_abstract_attachment_id":110399742},"translated_abstract":null,"internal_url":"https://www.academia.edu/113442384/A_quantitative_study_of_blood_brain_barrier_permeability_ultrastructure_in_a_new_rat_glioma_model","translated_internal_url":"","created_at":"2024-01-13T11:57:23.522-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110399742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399742/thumbnails/1.jpg","file_name":"BF00688129.pdf","download_url":"https://www.academia.edu/attachments/110399742/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_quantitative_study_of_blood_brain_barr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399742/BF00688129-libre.pdf?1705176154=\u0026response-content-disposition=attachment%3B+filename%3DA_quantitative_study_of_blood_brain_barr.pdf\u0026Expires=1732807502\u0026Signature=gUa0o~JFqL~qJv0p-Fcow95F3VvwqHDUn19Dr3v-Vsq0vqth3kGVbyvhhgI4T1wvOXKUhgtH7JAqb4AP9WrzaICNmtITKK-xnQjAt7Xiu3aYelkxGwHTDFa0fTK~OltcbzobWe21Qw4Gy7hI8qExYXzVMJCZWW3EIv2ut0BrMSIwDOQ5P7pF74kvFK~6YkTJ8YtqCgyZw-wHHUhRcy59kxDm4QB2im-FeGZIkhiiF1xdmhFBTMewS6MCRPRahrMj-H5yHtGKOiJUXeJm~hMJ7pv955hJ2swTl6uZNtjmkncDxWFRfoPoKhDrP0tNSM8G5H9LtjcoZjkM0SbQa8Pq6A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_quantitative_study_of_blood_brain_barrier_permeability_ultrastructure_in_a_new_rat_glioma_model","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":110399742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399742/thumbnails/1.jpg","file_name":"BF00688129.pdf","download_url":"https://www.academia.edu/attachments/110399742/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_quantitative_study_of_blood_brain_barr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399742/BF00688129-libre.pdf?1705176154=\u0026response-content-disposition=attachment%3B+filename%3DA_quantitative_study_of_blood_brain_barr.pdf\u0026Expires=1732807502\u0026Signature=gUa0o~JFqL~qJv0p-Fcow95F3VvwqHDUn19Dr3v-Vsq0vqth3kGVbyvhhgI4T1wvOXKUhgtH7JAqb4AP9WrzaICNmtITKK-xnQjAt7Xiu3aYelkxGwHTDFa0fTK~OltcbzobWe21Qw4Gy7hI8qExYXzVMJCZWW3EIv2ut0BrMSIwDOQ5P7pF74kvFK~6YkTJ8YtqCgyZw-wHHUhRcy59kxDm4QB2im-FeGZIkhiiF1xdmhFBTMewS6MCRPRahrMj-H5yHtGKOiJUXeJm~hMJ7pv955hJ2swTl6uZNtjmkncDxWFRfoPoKhDrP0tNSM8G5H9LtjcoZjkM0SbQa8Pq6A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":15719,"name":"Mitochondria","url":"https://www.academia.edu/Documents/in/Mitochondria"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":98913,"name":"Blood brain barrier","url":"https://www.academia.edu/Documents/in/Blood_brain_barrier"},{"id":138877,"name":"Vascular endothelium","url":"https://www.academia.edu/Documents/in/Vascular_endothelium"},{"id":212476,"name":"Ultrastructure","url":"https://www.academia.edu/Documents/in/Ultrastructure"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":557543,"name":"Blood Vessels","url":"https://www.academia.edu/Documents/in/Blood_Vessels"},{"id":788667,"name":"ENDOTHELIUM","url":"https://www.academia.edu/Documents/in/ENDOTHELIUM"},{"id":1142512,"name":"Vascular Permeability","url":"https://www.academia.edu/Documents/in/Vascular_Permeability"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1251210,"name":"Blood Vessel","url":"https://www.academia.edu/Documents/in/Blood_Vessel"},{"id":1363401,"name":"Brain Edema","url":"https://www.academia.edu/Documents/in/Brain_Edema"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"}],"urls":[{"id":38532189,"url":"http://link.springer.com/content/pdf/10.1007/BF00688129.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113442309"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442309/Suturing_Technique_and_the_Integrity_of_Dural_Closures_An_in_Vitro_Study"><img alt="Research paper thumbnail of Suturing Technique and the Integrity of Dural Closures: An in Vitro Study" class="work-thumbnail" src="https://attachments.academia-assets.com/110399716/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442309/Suturing_Technique_and_the_Integrity_of_Dural_Closures_An_in_Vitro_Study">Suturing Technique and the Integrity of Dural Closures: An in Vitro Study</a></div><div class="wp-workCard_item"><span>Neurosurgery</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cca54bb777db4778dc172f84f6d1ae4d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399716,"asset_id":113442309,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399716/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442309"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442309"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442309; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442309]").text(description); $(".js-view-count[data-work-id=113442309]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442309; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442309']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442309, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Nevertheless, for any given operator and type of suture, it is still not certain which suturing technique affords the most watertight dural closure. We have developed a laboratory model that allows us to compare the pressures at which dural closures leak when different suturing techniques are used. METHODS: Human cadaveric dura was secured to a glass cylinder filled with colored saline. By application of force to a bag of saline attached to the cylinder, the pressure at which sutured dural incisions leak can be recorded. Using this method, we have compared the closure of 2-cm dural incisions with 3-0 silk using the following techniques (10 per group): 1) interrupted simple, 2) running simple, 3) running locked, and 4) interrupted vertical mattress. We have also compared the closure of 1-ϫ 3-cm dural windows with cadaveric dura and 3-0 silk using the same suturing techniques (10 per group). RESULTS: The pressure at which 2-cm linear dural incisions leaked was significantly higher when they were closed with the interrupted simple suturing technique (P Ͻ 0.05). There was no significant difference among the different suturing techniques when they were used to close a 1-ϫ 3-cm dural window with a duraplasty. Overall, the pressures at which sutured linear dural incisions leaked were higher than the pressures at which sutured dural windows closed with duraplasties leaked. CONCLUSION: In the experimental model described, an interrupted simple suturing technique affords the most watertight dural closure for linear incisions, whereas no suturing technique proved advantageous for the closure of a duraplasty.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Neurosurgery","grobid_abstract_attachment_id":110399716},"translated_abstract":null,"internal_url":"https://www.academia.edu/113442309/Suturing_Technique_and_the_Integrity_of_Dural_Closures_An_in_Vitro_Study","translated_internal_url":"","created_at":"2024-01-13T11:55:51.708-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110399716,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399716/thumbnails/1.jpg","file_name":"01.neu.0000138441.07112.1b20240113-1-kdc6sp.pdf","download_url":"https://www.academia.edu/attachments/110399716/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Suturing_Technique_and_the_Integrity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399716/01.neu.0000138441.07112.1b20240113-1-kdc6sp-libre.pdf?1705176160=\u0026response-content-disposition=attachment%3B+filename%3DSuturing_Technique_and_the_Integrity_of.pdf\u0026Expires=1732807502\u0026Signature=VF7BiBfM0FmAavS3BtOzk12eyvXn59VajUA30MHNeYI21DYVVtkNiZJtFvi6CLWLjpWcxE4Awasfizik85HP7ye8khPiSQ915w7qebW4LZmINas-Bfy-bxoe1yTpW4ybIKLkb55mVh9ohvMvCCjoL~NID~48Yl0hXWEwxqGYG5cHcSVbkwFA34xhJzrGnpN2GFqV04tfTv9ADIzdG0ieEU4ds~OsK4nbXcOrti47yhczFo583h3TAY~Zdfu0HdA0Asimemu-jjd4bB9xkNJFLDEfXrwmzViyhvNUNK5nU6ecuzcWfR7Z9vMkC~WBKwRbtoGhCBN9q2Xzu9QsbgE1LQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Suturing_Technique_and_the_Integrity_of_Dural_Closures_An_in_Vitro_Study","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":110399716,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399716/thumbnails/1.jpg","file_name":"01.neu.0000138441.07112.1b20240113-1-kdc6sp.pdf","download_url":"https://www.academia.edu/attachments/110399716/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Suturing_Technique_and_the_Integrity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399716/01.neu.0000138441.07112.1b20240113-1-kdc6sp-libre.pdf?1705176160=\u0026response-content-disposition=attachment%3B+filename%3DSuturing_Technique_and_the_Integrity_of.pdf\u0026Expires=1732807502\u0026Signature=VF7BiBfM0FmAavS3BtOzk12eyvXn59VajUA30MHNeYI21DYVVtkNiZJtFvi6CLWLjpWcxE4Awasfizik85HP7ye8khPiSQ915w7qebW4LZmINas-Bfy-bxoe1yTpW4ybIKLkb55mVh9ohvMvCCjoL~NID~48Yl0hXWEwxqGYG5cHcSVbkwFA34xhJzrGnpN2GFqV04tfTv9ADIzdG0ieEU4ds~OsK4nbXcOrti47yhczFo583h3TAY~Zdfu0HdA0Asimemu-jjd4bB9xkNJFLDEfXrwmzViyhvNUNK5nU6ecuzcWfR7Z9vMkC~WBKwRbtoGhCBN9q2Xzu9QsbgE1LQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":650,"name":"Neurosurgery","url":"https://www.academia.edu/Documents/in/Neurosurgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":247948,"name":"Cadaver","url":"https://www.academia.edu/Documents/in/Cadaver"},{"id":280139,"name":"Suture","url":"https://www.academia.edu/Documents/in/Suture"},{"id":546400,"name":"Postoperative Hemorrhage","url":"https://www.academia.edu/Documents/in/Postoperative_Hemorrhage"},{"id":780594,"name":"In Vitro Studies","url":"https://www.academia.edu/Documents/in/In_Vitro_Studies"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications"},{"id":3123412,"name":"Cerebrospinal Fluid Leak Repair","url":"https://www.academia.edu/Documents/in/Cerebrospinal_Fluid_Leak_Repair"},{"id":3153703,"name":"Suture techniques","url":"https://www.academia.edu/Documents/in/Suture_techniques"},{"id":3996792,"name":"Dura mater","url":"https://www.academia.edu/Documents/in/Dura_mater"}],"urls":[{"id":38532170,"url":"http://academic.oup.com/neurosurgery/article-pdf/55/4/950/10971647/00006123-200410000-00032.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80146522"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80146522/A_free_radical_approach_to_tissue_injury"><img alt="Research paper thumbnail of A free radical approach to tissue injury" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80146522/A_free_radical_approach_to_tissue_injury">A free radical approach to tissue injury</a></div><div class="wp-workCard_item"><span>Organ Preservation</span><span>, 1982</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Problems associated with hypoxic tissue damage emerge as central constraints in cardiovascular, n...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Problems associated with hypoxic tissue damage emerge as central constraints in cardiovascular, neurosurgical and transplantation surgery. Achievements in these fields have been predominantly the results of advances in surgical techniques, medical and intensive-care methods.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80146522"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80146522"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80146522; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80146522]").text(description); $(".js-view-count[data-work-id=80146522]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80146522; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80146522']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80146522, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=80146522]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80146522,"title":"A free radical approach to tissue injury","translated_title":"","metadata":{"abstract":"Problems associated with hypoxic tissue damage emerge as central constraints in cardiovascular, neurosurgical and transplantation surgery. 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Achievements in these fields have been predominantly the results of advances in surgical techniques, medical and intensive-care methods.","internal_url":"https://www.academia.edu/80146522/A_free_radical_approach_to_tissue_injury","translated_internal_url":"","created_at":"2022-05-28T17:56:30.462-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_free_radical_approach_to_tissue_injury","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":203424,"name":"Organ Preservation","url":"https://www.academia.edu/Documents/in/Organ_Preservation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="67349217"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/67349217/Free_radicals_as_mediators_of_tissue_injury"><img alt="Research paper thumbnail of Free radicals as mediators of tissue injury" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/67349217/Free_radicals_as_mediators_of_tissue_injury">Free radicals as mediators of tissue injury</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RolandoMaestro">Rolando Maestro</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HowardThaw">Howard H Thaw</a></span></div><div class="wp-workCard_item"><span>Acta physiologica Scandinavica. Supplementum</span><span>, 1980</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polymorphonuclear leukocytes and other inflammatory cells on exposure to appropriate stimuli rele...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polymorphonuclear leukocytes and other inflammatory cells on exposure to appropriate stimuli release superoxide anion radical into the extracellular space. This results in the further generation of other activated oxygen species such as hydrogen peroxide, hydroxyl radical and singlet oxygen. We have assessed the influence of activated oxygen species, generated by substrate-xanthine oxidase systems, on the degradation of hyaluronic acid, human glial cells in culture and the microcirculation of the hamster cheek pouch. Hyaluronic acid degradation was observed and morphological changes, culminating in cell death, were seen in glial cells. Increased microvascular permeability and increased polymorphonuclear leukocyte-endothelial adhesion were also observed. The results suggest that a variety of alterations to macromolecular and cellular elements of tissues can be mediated by specific free radical species. Similar mechanisms may play a role in the structural and cellular injury occurring...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="67349217"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="67349217"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67349217; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67349217]").text(description); $(".js-view-count[data-work-id=67349217]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67349217; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='67349217']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 67349217, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=67349217]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":67349217,"title":"Free radicals as mediators of tissue injury","translated_title":"","metadata":{"abstract":"Polymorphonuclear leukocytes and other inflammatory cells on exposure to appropriate stimuli release superoxide anion radical into the extracellular space. This results in the further generation of other activated oxygen species such as hydrogen peroxide, hydroxyl radical and singlet oxygen. We have assessed the influence of activated oxygen species, generated by substrate-xanthine oxidase systems, on the degradation of hyaluronic acid, human glial cells in culture and the microcirculation of the hamster cheek pouch. Hyaluronic acid degradation was observed and morphological changes, culminating in cell death, were seen in glial cells. Increased microvascular permeability and increased polymorphonuclear leukocyte-endothelial adhesion were also observed. The results suggest that a variety of alterations to macromolecular and cellular elements of tissues can be mediated by specific free radical species. Similar mechanisms may play a role in the structural and cellular injury occurring...","publisher":"Acta physiologica Scandinavica. Supplementum","publication_date":{"day":null,"month":null,"year":1980,"errors":{}},"publication_name":"Acta physiologica Scandinavica. Supplementum"},"translated_abstract":"Polymorphonuclear leukocytes and other inflammatory cells on exposure to appropriate stimuli release superoxide anion radical into the extracellular space. This results in the further generation of other activated oxygen species such as hydrogen peroxide, hydroxyl radical and singlet oxygen. We have assessed the influence of activated oxygen species, generated by substrate-xanthine oxidase systems, on the degradation of hyaluronic acid, human glial cells in culture and the microcirculation of the hamster cheek pouch. Hyaluronic acid degradation was observed and morphological changes, culminating in cell death, were seen in glial cells. Increased microvascular permeability and increased polymorphonuclear leukocyte-endothelial adhesion were also observed. The results suggest that a variety of alterations to macromolecular and cellular elements of tissues can be mediated by specific free radical species. Similar mechanisms may play a role in the structural and cellular injury occurring...","internal_url":"https://www.academia.edu/67349217/Free_radicals_as_mediators_of_tissue_injury","translated_internal_url":"","created_at":"2022-01-06T02:20:39.770-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":5370266,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":37887392,"work_id":67349217,"tagging_user_id":5370266,"tagged_user_id":46086183,"co_author_invite_id":null,"email":"r***o@mcgill.ca","display_order":0,"name":"Rolando Maestro","title":"Free radicals as mediators of tissue injury"},{"id":37887393,"work_id":67349217,"tagging_user_id":5370266,"tagged_user_id":11242026,"co_author_invite_id":null,"email":"a***s@gmail.com","display_order":4194304,"name":"Karl E. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025540"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025540/Face_content_and_construct_validity_of_human_placenta_as_a_haptic_training_tool_in_neurointerventional_surgery"><img alt="Research paper thumbnail of Face, content, and construct validity of human placenta as a haptic training tool in neurointerventional surgery" class="work-thumbnail" src="https://attachments.academia-assets.com/75591477/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025540/Face_content_and_construct_validity_of_human_placenta_as_a_haptic_training_tool_in_neurointerventional_surgery">Face, content, and construct validity of human placenta as a haptic training tool in neurointerventional surgery</a></div><div class="wp-workCard_item"><span>Journal of neurosurgery</span><span>, Jan 9, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">OBJECT The development of neurointerventional treatments of central nervous system disorders has ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">OBJECT The development of neurointerventional treatments of central nervous system disorders has resulted in the need for adequate training environments for novice interventionalists. Virtual simulators offer anatomical definition but lack adequate tactile feedback. Animal models, which provide more lifelike training, require an appropriate infrastructure base. The authors describe a training model for neurointerventional procedures using the human placenta (HP), which affords haptic training with significantly fewer resource requirements, and discuss its validation. METHODS Twelve HPs were prepared for simulated endovascular procedures. Training exercises performed by interventional neuroradiologists and novice fellows were placental angiography, stent placement, aneurysm coiling, and intravascular liquid embolic agent injection. RESULTS The endovascular training exercises proposed can be easily reproduced in the HP. Face, content, and construct validity were assessed by 6 neuroint...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5faecf636f74343e0516b86a7f0359f8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75591477,"asset_id":63025540,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75591477/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025540"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025540"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025540; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025540]").text(description); $(".js-view-count[data-work-id=63025540]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025540; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025540']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025540, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5faecf636f74343e0516b86a7f0359f8" } } $('.js-work-strip[data-work-id=63025540]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025540,"title":"Face, content, and construct validity of human placenta as a haptic training tool in neurointerventional surgery","translated_title":"","metadata":{"abstract":"OBJECT The development of neurointerventional treatments of central nervous system disorders has resulted in the need for adequate training environments for novice interventionalists. Virtual simulators offer anatomical definition but lack adequate tactile feedback. Animal models, which provide more lifelike training, require an appropriate infrastructure base. The authors describe a training model for neurointerventional procedures using the human placenta (HP), which affords haptic training with significantly fewer resource requirements, and discuss its validation. METHODS Twelve HPs were prepared for simulated endovascular procedures. Training exercises performed by interventional neuroradiologists and novice fellows were placental angiography, stent placement, aneurysm coiling, and intravascular liquid embolic agent injection. RESULTS The endovascular training exercises proposed can be easily reproduced in the HP. 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Training exercises performed by interventional neuroradiologists and novice fellows were placental angiography, stent placement, aneurysm coiling, and intravascular liquid embolic agent injection. RESULTS The endovascular training exercises proposed can be easily reproduced in the HP. Face, content, and construct validity were assessed by 6 neuroint...","internal_url":"https://www.academia.edu/63025540/Face_content_and_construct_validity_of_human_placenta_as_a_haptic_training_tool_in_neurointerventional_surgery","translated_internal_url":"","created_at":"2021-12-02T14:27:58.666-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75591477,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591477/thumbnails/1.jpg","file_name":"3b8e55e5aed56f952803b7893266e2978b73.pdf","download_url":"https://www.academia.edu/attachments/75591477/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Face_content_and_construct_validity_of_h.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591477/3b8e55e5aed56f952803b7893266e2978b73-libre.pdf?1638487316=\u0026response-content-disposition=attachment%3B+filename%3DFace_content_and_construct_validity_of_h.pdf\u0026Expires=1732807502\u0026Signature=TjEeT-O2t7OhyhfrUYq~oFQBWjJp8UZNzjhn5pQhLr8C9g7D-vXl8dqFArtcfXYDe8f6UdeTYxkCsfJrGeAZ2om5RrCxd83ktACcALSEXI2168NSDnCcy7edwDsj-h9rNXewnI0wiVJk5oJIXrixcFL~QMaRykjxouIgMOcnBm1tnArmIjtkOkR6y5vRf5MgQkx5tkgSOQCdzhLXlF7mGCmRJxKDf3bBQariJ1-YX8mR3wU0Z-yMBBqM6zU~Bpe7biEIA6HvVOzNgv22ATaApC5QeMGdD3bTIMtH-T6y4B0g~9w3grga8dpEgWFlLIHpElrEYkllnUmaLTt9DgcYiQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Face_content_and_construct_validity_of_human_placenta_as_a_haptic_training_tool_in_neurointerventional_surgery","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":75591477,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591477/thumbnails/1.jpg","file_name":"3b8e55e5aed56f952803b7893266e2978b73.pdf","download_url":"https://www.academia.edu/attachments/75591477/download_file?st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Face_content_and_construct_validity_of_h.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591477/3b8e55e5aed56f952803b7893266e2978b73-libre.pdf?1638487316=\u0026response-content-disposition=attachment%3B+filename%3DFace_content_and_construct_validity_of_h.pdf\u0026Expires=1732807502\u0026Signature=TjEeT-O2t7OhyhfrUYq~oFQBWjJp8UZNzjhn5pQhLr8C9g7D-vXl8dqFArtcfXYDe8f6UdeTYxkCsfJrGeAZ2om5RrCxd83ktACcALSEXI2168NSDnCcy7edwDsj-h9rNXewnI0wiVJk5oJIXrixcFL~QMaRykjxouIgMOcnBm1tnArmIjtkOkR6y5vRf5MgQkx5tkgSOQCdzhLXlF7mGCmRJxKDf3bBQariJ1-YX8mR3wU0Z-yMBBqM6zU~Bpe7biEIA6HvVOzNgv22ATaApC5QeMGdD3bTIMtH-T6y4B0g~9w3grga8dpEgWFlLIHpElrEYkllnUmaLTt9DgcYiQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":650,"name":"Neurosurgery","url":"https://www.academia.edu/Documents/in/Neurosurgery"},{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":247701,"name":"Angiography","url":"https://www.academia.edu/Documents/in/Angiography"},{"id":704648,"name":"Clinical Competence","url":"https://www.academia.edu/Documents/in/Clinical_Competence"},{"id":1205102,"name":"Cerebrovascular Disorders","url":"https://www.academia.edu/Documents/in/Cerebrovascular_Disorders"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1909338,"name":"Endovascular Procedures","url":"https://www.academia.edu/Documents/in/Endovascular_Procedures"},{"id":3208250,"name":"Intracranial aneurysm","url":"https://www.academia.edu/Documents/in/Intracranial_aneurysm"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025539"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025539/Face_Content_and_Construct_Validity_of_Brain_Tumor_Microsurgery_Simulation_Using_a_Human_Placenta_Model"><img alt="Research paper thumbnail of Face, Content, and Construct Validity of Brain Tumor Microsurgery Simulation Using a Human Placenta Model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025539/Face_Content_and_Construct_Validity_of_Brain_Tumor_Microsurgery_Simulation_Using_a_Human_Placenta_Model">Face, Content, and Construct Validity of Brain Tumor Microsurgery Simulation Using a Human Placenta Model</a></div><div class="wp-workCard_item"><span>Neurosurgery</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND Brain tumors are complex 3-dimensional lesions. Their resection involves training and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND Brain tumors are complex 3-dimensional lesions. Their resection involves training and the use of the multiple microsurgical techniques available for removal. Simulation models, with haptic and visual realism, may be useful for improving the bimanual technical skills of neurosurgical residents and neurosurgeons, potentially decreasing surgical errors and thus improving patient outcomes. OBJECTIVE To describe and assess an ex vivo placental model for brain tumor microsurgery using a simulation tool in neurosurgical psychomotor teaching and assessment. METHODS Sixteen human placentas were used in this research project. Intravascular blood remnants were removed by continuous saline solution irrigation of the 2 placental arteries and placental vein. Brain tumors were simulated using silicone injections in the placental stroma. Eight neurosurgeons and 8 neurosurgical residents carried out the resection of simulated tumors using the same surgical instruments and bimanual microsu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025539"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025539"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025539; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025539]").text(description); $(".js-view-count[data-work-id=63025539]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025539; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025539']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025539, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63025539]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025539,"title":"Face, Content, and Construct Validity of Brain Tumor Microsurgery Simulation Using a Human Placenta Model","translated_title":"","metadata":{"abstract":"BACKGROUND Brain tumors are complex 3-dimensional lesions. Their resection involves training and the use of the multiple microsurgical techniques available for removal. Simulation models, with haptic and visual realism, may be useful for improving the bimanual technical skills of neurosurgical residents and neurosurgeons, potentially decreasing surgical errors and thus improving patient outcomes. OBJECTIVE To describe and assess an ex vivo placental model for brain tumor microsurgery using a simulation tool in neurosurgical psychomotor teaching and assessment. METHODS Sixteen human placentas were used in this research project. Intravascular blood remnants were removed by continuous saline solution irrigation of the 2 placental arteries and placental vein. Brain tumors were simulated using silicone injections in the placental stroma. Eight neurosurgeons and 8 neurosurgical residents carried out the resection of simulated tumors using the same surgical instruments and bimanual microsu...","publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Neurosurgery"},"translated_abstract":"BACKGROUND Brain tumors are complex 3-dimensional lesions. Their resection involves training and the use of the multiple microsurgical techniques available for removal. Simulation models, with haptic and visual realism, may be useful for improving the bimanual technical skills of neurosurgical residents and neurosurgeons, potentially decreasing surgical errors and thus improving patient outcomes. OBJECTIVE To describe and assess an ex vivo placental model for brain tumor microsurgery using a simulation tool in neurosurgical psychomotor teaching and assessment. METHODS Sixteen human placentas were used in this research project. Intravascular blood remnants were removed by continuous saline solution irrigation of the 2 placental arteries and placental vein. Brain tumors were simulated using silicone injections in the placental stroma. Eight neurosurgeons and 8 neurosurgical residents carried out the resection of simulated tumors using the same surgical instruments and bimanual microsu...","internal_url":"https://www.academia.edu/63025539/Face_Content_and_Construct_Validity_of_Brain_Tumor_Microsurgery_Simulation_Using_a_Human_Placenta_Model","translated_internal_url":"","created_at":"2021-12-02T14:27:58.552-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Face_Content_and_Construct_Validity_of_Brain_Tumor_Microsurgery_Simulation_Using_a_Human_Placenta_Model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[],"research_interests":[{"id":650,"name":"Neurosurgery","url":"https://www.academia.edu/Documents/in/Neurosurgery"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025538"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025538/Effects_of_radiation_on_a_model_of_malignant_glioma_invasion"><img alt="Research paper thumbnail of Effects of radiation on a model of malignant glioma invasion" class="work-thumbnail" src="https://attachments.academia-assets.com/75591482/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025538/Effects_of_radiation_on_a_model_of_malignant_glioma_invasion">Effects of radiation on a model of malignant glioma invasion</a></div><div class="wp-workCard_item"><span>Journal of neuro-oncology</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We sought to characterize the effects of radiation alone and in combination with BCNU and dexamet...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We sought to characterize the effects of radiation alone and in combination with BCNU and dexamethasone on malignant glioma invasion. A model of malignant glioma invasion into a gel matrix of collagen type I was used to characterize response to radiation treatment for four malignant glioma cell lines (C6, U251, U373, A172) and nine primary human glioblastoma explants. A radiation dose dependent inhibition of invasion was noted for the C6 astrocytoma cell line but not the other cell lines or explants. Addition of BCNU and dexamethasone to radiation produced additional inhibition of invasion among the cell lines and explants but could not suppress invasion entirely.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b5e0aea61b9f8a84d13cb4849744f8c1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75591482,"asset_id":63025538,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75591482/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025538"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025538"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025538; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025538]").text(description); $(".js-view-count[data-work-id=63025538]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025538; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025538']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025538, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b5e0aea61b9f8a84d13cb4849744f8c1" } } $('.js-work-strip[data-work-id=63025538]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025538,"title":"Effects of radiation on a model of malignant glioma invasion","translated_title":"","metadata":{"abstract":"We sought to characterize the effects of radiation alone and in combination with BCNU and dexamethasone on malignant glioma invasion. 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Addition of BCNU and dexamethasone to radiation produced additional inhibition of invasion among the cell lines and explants but could not suppress invasion entirely.","internal_url":"https://www.academia.edu/63025538/Effects_of_radiation_on_a_model_of_malignant_glioma_invasion","translated_internal_url":"","created_at":"2021-12-02T14:27:58.459-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75591482,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591482/thumbnails/1.jpg","file_name":"a_3A100631941707720211202-8113-88diu9.pdf","download_url":"https://www.academia.edu/attachments/75591482/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_radiation_on_a_model_of_malig.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591482/a_3A100631941707720211202-8113-88diu9-libre.pdf?1638487308=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_radiation_on_a_model_of_malig.pdf\u0026Expires=1732807502\u0026Signature=bL0mV4GqA27Rhv2Q1KKqiWayufDHkPtRuOAsekBP38JXFqikgkNJyFJbqk~DceuI5O7EEp7MRWsctCJ2FL9jTjuYuQEoprmtmIT3VZ48MSTyP2x451g134gcBw88XOgyLXcris8ETIgSechEEqztwxB9JU71LkOGvF~f9iVcUBdWuQh9w-LQ8xZx1ssDWp6-~uXyeq~rpXDVdbidGjNkzs91HT0AxkFs5-aoO7ecC9AgPXe8WG~TlDj-GoMSPOsdx79KmckhwtbGMn6Nwii~0c-1NP5pRFMxeiiSiK9caeFV27UDo~QXyr1PGTa3xyD5MUuPMlsBcaNXu~eEf46nZg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effects_of_radiation_on_a_model_of_malignant_glioma_invasion","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":75591482,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591482/thumbnails/1.jpg","file_name":"a_3A100631941707720211202-8113-88diu9.pdf","download_url":"https://www.academia.edu/attachments/75591482/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_radiation_on_a_model_of_malig.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591482/a_3A100631941707720211202-8113-88diu9-libre.pdf?1638487308=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_radiation_on_a_model_of_malig.pdf\u0026Expires=1732807503\u0026Signature=gq-7ZScuDxzHnjwsSFZvt9tM3FEv0yBjDK~xnPFxGJIss0f6RyP~0h6yakj~L0So2m81dgZuMKMM~UO4CXPRRGVu3GRLzbi~mT~GWhNtTW7U1y9Pj2O6O6D3HeQ22fSsaFeX4DwiFexeFSx5NfKyhDU9mBRbUDCa2YDw2VsOShagk4JClNl3PtNmz9q8xXDsPXCYTgQfCl0zCpilqYW-bqqYdiNymQrAQLfwnbKKl4dZbZdtqV5KZJlDJRYEIHsoaOfqtI2uC3HLW4ntjQT62V2gnd5trL1eB72bKRWD67BlzCd4hHHybXpsJDnL9AL1O7IsT9tBR9gObLTurSTRUQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":57801,"name":"Dexamethasone","url":"https://www.academia.edu/Documents/in/Dexamethasone"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":91499,"name":"Glioblastoma","url":"https://www.academia.edu/Documents/in/Glioblastoma"},{"id":127604,"name":"Neuro","url":"https://www.academia.edu/Documents/in/Neuro"},{"id":371494,"name":"Neoplasm Invasiveness","url":"https://www.academia.edu/Documents/in/Neoplasm_Invasiveness"},{"id":389506,"name":"Radiation Dose","url":"https://www.academia.edu/Documents/in/Radiation_Dose"},{"id":573989,"name":"Malignant Glioma","url":"https://www.academia.edu/Documents/in/Malignant_Glioma"},{"id":859051,"name":"Astrocytoma","url":"https://www.academia.edu/Documents/in/Astrocytoma"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025537"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025537/Radiation_induced_cavernous_hemangiomas_case_report_and_literature_review"><img alt="Research paper thumbnail of Radiation-induced cavernous hemangiomas: case report and literature review" class="work-thumbnail" src="https://attachments.academia-assets.com/75591484/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025537/Radiation_induced_cavernous_hemangiomas_case_report_and_literature_review">Radiation-induced cavernous hemangiomas: case report and literature review</a></div><div class="wp-workCard_item"><span>The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cranial irradiation for a cerebellar astrocytoma is reported. A review of 84 cases of radiation-induced cavernous hemangiomas found in the literature is presented. In this series the mean age at the time of irradiation (+/- SD) was 10.4 +/- 2.0 years (median = 8 years), while the mean time to cavernous hemangioma diagnosis (+/- SD) was 10.3 +/- 1.9 years (median = 8 years). Time to cavernous hemangioma diagnosis was found to be inversely related to radiation dose. Hemorrhage from radiation-induced cavernous hemangiomas was found in 40.0% of patients, with an incidence of 3.9% per patient year. An inverse trend was identified between radiation dose and symptomatic presentation, cavernous hemangioma hemorrhage or surgical resection. This review of radiation-induced cavernous hemangiomas confirms that both younger patients and those who received a larger dose of radiation are at increased ris...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b187511dda47851a810070c2b776b8a7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75591484,"asset_id":63025537,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75591484/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025537"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025537"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025537; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025537]").text(description); $(".js-view-count[data-work-id=63025537]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025537; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025537']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025537, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b187511dda47851a810070c2b776b8a7" } } $('.js-work-strip[data-work-id=63025537]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025537,"title":"Radiation-induced cavernous hemangiomas: case report and literature review","translated_title":"","metadata":{"abstract":"The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cranial irradiation for a cerebellar astrocytoma is reported. A review of 84 cases of radiation-induced cavernous hemangiomas found in the literature is presented. In this series the mean age at the time of irradiation (+/- SD) was 10.4 +/- 2.0 years (median = 8 years), while the mean time to cavernous hemangioma diagnosis (+/- SD) was 10.3 +/- 1.9 years (median = 8 years). Time to cavernous hemangioma diagnosis was found to be inversely related to radiation dose. Hemorrhage from radiation-induced cavernous hemangiomas was found in 40.0% of patients, with an incidence of 3.9% per patient year. An inverse trend was identified between radiation dose and symptomatic presentation, cavernous hemangioma hemorrhage or surgical resection. This review of radiation-induced cavernous hemangiomas confirms that both younger patients and those who received a larger dose of radiation are at increased ris...","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques"},"translated_abstract":"The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cranial irradiation for a cerebellar astrocytoma is reported. A review of 84 cases of radiation-induced cavernous hemangiomas found in the literature is presented. In this series the mean age at the time of irradiation (+/- SD) was 10.4 +/- 2.0 years (median = 8 years), while the mean time to cavernous hemangioma diagnosis (+/- SD) was 10.3 +/- 1.9 years (median = 8 years). Time to cavernous hemangioma diagnosis was found to be inversely related to radiation dose. Hemorrhage from radiation-induced cavernous hemangiomas was found in 40.0% of patients, with an incidence of 3.9% per patient year. An inverse trend was identified between radiation dose and symptomatic presentation, cavernous hemangioma hemorrhage or surgical resection. This review of radiation-induced cavernous hemangiomas confirms that both younger patients and those who received a larger dose of radiation are at increased ris...","internal_url":"https://www.academia.edu/63025537/Radiation_induced_cavernous_hemangiomas_case_report_and_literature_review","translated_internal_url":"","created_at":"2021-12-02T14:27:58.365-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75591484,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591484/thumbnails/1.jpg","file_name":"fcbb6c4a9559f82bc03f2bfc43f5ede918ba.pdf","download_url":"https://www.academia.edu/attachments/75591484/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Radiation_induced_cavernous_hemangiomas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591484/fcbb6c4a9559f82bc03f2bfc43f5ede918ba-libre.pdf?1638487309=\u0026response-content-disposition=attachment%3B+filename%3DRadiation_induced_cavernous_hemangiomas.pdf\u0026Expires=1732807503\u0026Signature=b8-m37RA0wHtkFC7CRwyTggnAr4LDAL5pMyA1uraKeS1P58QlmmGUioi7r1grgoTXFy5thcLHK8zg5ncMqblbpB69bpnWW~ZfF8sBs4zCLpyGYgbeWpUGldVDI039P12QkD2eDLH3czVTqFel0QxIA-3LmcaqtJLXDLxglKIdCwtvcfuZgUCMatiVo~ZVG1oQlYBcgHq~FkH2G1zDWQWjIAZkwQAQK0K1moliZSUVQP-OyyeuYWkLo-e83PtNGbVK1IRAx49wRWcqP5CqwRKe6iSnLHJ-vUz00qQVFzu3vbozaiCbI23pnJM~EzRgJcE6j8VfjVps6wBz1tRc2VE7A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Radiation_induced_cavernous_hemangiomas_case_report_and_literature_review","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":75591484,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591484/thumbnails/1.jpg","file_name":"fcbb6c4a9559f82bc03f2bfc43f5ede918ba.pdf","download_url":"https://www.academia.edu/attachments/75591484/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Radiation_induced_cavernous_hemangiomas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591484/fcbb6c4a9559f82bc03f2bfc43f5ede918ba-libre.pdf?1638487309=\u0026response-content-disposition=attachment%3B+filename%3DRadiation_induced_cavernous_hemangiomas.pdf\u0026Expires=1732807503\u0026Signature=b8-m37RA0wHtkFC7CRwyTggnAr4LDAL5pMyA1uraKeS1P58QlmmGUioi7r1grgoTXFy5thcLHK8zg5ncMqblbpB69bpnWW~ZfF8sBs4zCLpyGYgbeWpUGldVDI039P12QkD2eDLH3czVTqFel0QxIA-3LmcaqtJLXDLxglKIdCwtvcfuZgUCMatiVo~ZVG1oQlYBcgHq~FkH2G1zDWQWjIAZkwQAQK0K1moliZSUVQP-OyyeuYWkLo-e83PtNGbVK1IRAx49wRWcqP5CqwRKe6iSnLHJ-vUz00qQVFzu3vbozaiCbI23pnJM~EzRgJcE6j8VfjVps6wBz1tRc2VE7A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025536"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025536/Dynamics_of_C6_astrocytoma_invasion_into_three_dimensional_collagen_gels"><img alt="Research paper thumbnail of Dynamics of C6 astrocytoma invasion into three-dimensional collagen gels" class="work-thumbnail" src="https://attachments.academia-assets.com/75591519/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025536/Dynamics_of_C6_astrocytoma_invasion_into_three_dimensional_collagen_gels">Dynamics of C6 astrocytoma invasion into three-dimensional collagen gels</a></div><div class="wp-workCard_item"><span>Journal of neuro-oncology</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The dynamic mechanisms underlying the three-dimensional invasive paradigm of C6 astrocytoma cells...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The dynamic mechanisms underlying the three-dimensional invasive paradigm of C6 astrocytoma cells has been assessed. Spheroids of C6 astrocytoma cells were implanted into three-dimensional collagen type I gels (vitrogen 100) and individual C6 astrocytoma cell invasion monitored. Time-lapsed videomicroscopy was used to assess the dynamic components of cell invasion in three dimensions while scanning and transmission electron microscopy were used to assess matrix architecture and the static aspects of cell invasion. Videomicroscopy outlined an invasion paradigm continuum with repeating phases. A cell surface ruffling phase was followed by invadopodia extension and pull up phases. For some cells the collagen type I matrix extracellular matrix appeared to modify the ability of C6 cells to carry out their invasion paradigm. C6 astrocytoma cells invading a three-dimensional collagen type I matrix utilize a invasion paradigm made up of a number of phases. A better understanding of the dyna...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5fdbeda0e32bf032694c1ddb8ff3f6fb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75591519,"asset_id":63025536,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75591519/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025536"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025536"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025536; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025536]").text(description); $(".js-view-count[data-work-id=63025536]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025536; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025536']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025536, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5fdbeda0e32bf032694c1ddb8ff3f6fb" } } $('.js-work-strip[data-work-id=63025536]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025536,"title":"Dynamics of C6 astrocytoma invasion into three-dimensional collagen gels","translated_title":"","metadata":{"abstract":"The dynamic mechanisms underlying the three-dimensional invasive paradigm of C6 astrocytoma cells has been assessed. Spheroids of C6 astrocytoma cells were implanted into three-dimensional collagen type I gels (vitrogen 100) and individual C6 astrocytoma cell invasion monitored. Time-lapsed videomicroscopy was used to assess the dynamic components of cell invasion in three dimensions while scanning and transmission electron microscopy were used to assess matrix architecture and the static aspects of cell invasion. Videomicroscopy outlined an invasion paradigm continuum with repeating phases. A cell surface ruffling phase was followed by invadopodia extension and pull up phases. For some cells the collagen type I matrix extracellular matrix appeared to modify the ability of C6 cells to carry out their invasion paradigm. C6 astrocytoma cells invading a three-dimensional collagen type I matrix utilize a invasion paradigm made up of a number of phases. A better understanding of the dyna...","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Journal of neuro-oncology"},"translated_abstract":"The dynamic mechanisms underlying the three-dimensional invasive paradigm of C6 astrocytoma cells has been assessed. Spheroids of C6 astrocytoma cells were implanted into three-dimensional collagen type I gels (vitrogen 100) and individual C6 astrocytoma cell invasion monitored. Time-lapsed videomicroscopy was used to assess the dynamic components of cell invasion in three dimensions while scanning and transmission electron microscopy were used to assess matrix architecture and the static aspects of cell invasion. Videomicroscopy outlined an invasion paradigm continuum with repeating phases. A cell surface ruffling phase was followed by invadopodia extension and pull up phases. For some cells the collagen type I matrix extracellular matrix appeared to modify the ability of C6 cells to carry out their invasion paradigm. C6 astrocytoma cells invading a three-dimensional collagen type I matrix utilize a invasion paradigm made up of a number of phases. A better understanding of the dyna...","internal_url":"https://www.academia.edu/63025536/Dynamics_of_C6_astrocytoma_invasion_into_three_dimensional_collagen_gels","translated_internal_url":"","created_at":"2021-12-02T14:27:58.268-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75591519,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591519/thumbnails/1.jpg","file_name":"a_3A101223683023020211202-24090-hw4ana.pdf","download_url":"https://www.academia.edu/attachments/75591519/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamics_of_C6_astrocytoma_invasion_into.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591519/a_3A101223683023020211202-24090-hw4ana-libre.pdf?1638487305=\u0026response-content-disposition=attachment%3B+filename%3DDynamics_of_C6_astrocytoma_invasion_into.pdf\u0026Expires=1732807503\u0026Signature=Ds~i3fjqf-Udo6G9bZCtvFOOVA0FKo6R6r5n~2LAab~3XiLgn3QSvLY6dRkR6HZGqPE9W-nz6D4BZsFaTb23fIdNPCkMG1v~j1DYpRMl14kH5EhCdTv0Cr~1089vIkKVCEXQ6klfYxu9V7xPQKP-JjF4GYJjM44GdHtQftyCtglBo2b0~MceUGR2Jof0WWJaPKCqDMSMQhTqXk7P3Pq7fAOzRwrImKbdSPyGm-yibwZXDqCbIMFCnhrjKxejIbccH0BHtwbcFxGUftOrojeI0JxqSvM9oJc6Ke4~wZc~T02lEO7t8HrVGUd2twt3y9kqQwOkaOP3VhViPLnRw4IHpA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dynamics_of_C6_astrocytoma_invasion_into_three_dimensional_collagen_gels","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":75591519,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591519/thumbnails/1.jpg","file_name":"a_3A101223683023020211202-24090-hw4ana.pdf","download_url":"https://www.academia.edu/attachments/75591519/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamics_of_C6_astrocytoma_invasion_into.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591519/a_3A101223683023020211202-24090-hw4ana-libre.pdf?1638487305=\u0026response-content-disposition=attachment%3B+filename%3DDynamics_of_C6_astrocytoma_invasion_into.pdf\u0026Expires=1732807503\u0026Signature=Ds~i3fjqf-Udo6G9bZCtvFOOVA0FKo6R6r5n~2LAab~3XiLgn3QSvLY6dRkR6HZGqPE9W-nz6D4BZsFaTb23fIdNPCkMG1v~j1DYpRMl14kH5EhCdTv0Cr~1089vIkKVCEXQ6klfYxu9V7xPQKP-JjF4GYJjM44GdHtQftyCtglBo2b0~MceUGR2Jof0WWJaPKCqDMSMQhTqXk7P3Pq7fAOzRwrImKbdSPyGm-yibwZXDqCbIMFCnhrjKxejIbccH0BHtwbcFxGUftOrojeI0JxqSvM9oJc6Ke4~wZc~T02lEO7t8HrVGUd2twt3y9kqQwOkaOP3VhViPLnRw4IHpA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3091,"name":"Microscopy","url":"https://www.academia.edu/Documents/in/Microscopy"},{"id":14079,"name":"Scanning Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Scanning_Transmission_Electron_Microscopy"},{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture"},{"id":62244,"name":"Video microscopy","url":"https://www.academia.edu/Documents/in/Video_microscopy"},{"id":62320,"name":"Dynamics","url":"https://www.academia.edu/Documents/in/Dynamics"},{"id":79808,"name":"Collagen","url":"https://www.academia.edu/Documents/in/Collagen"},{"id":127604,"name":"Neuro","url":"https://www.academia.edu/Documents/in/Neuro"},{"id":284907,"name":"Gels","url":"https://www.academia.edu/Documents/in/Gels"},{"id":371494,"name":"Neoplasm Invasiveness","url":"https://www.academia.edu/Documents/in/Neoplasm_Invasiveness"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":494469,"name":"Gel","url":"https://www.academia.edu/Documents/in/Gel"},{"id":504035,"name":"Three Dimensional","url":"https://www.academia.edu/Documents/in/Three_Dimensional"},{"id":859051,"name":"Astrocytoma","url":"https://www.academia.edu/Documents/in/Astrocytoma"},{"id":1145520,"name":"Equipment Design","url":"https://www.academia.edu/Documents/in/Equipment_Design"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025535"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025535/Preoperative_and_postoperative_functional_magnetic_resonance_imaging_and_intraoperative_assessment_of_mental_spatial_transformations_in_patients_undergoing_surgery_for_brain_tumors"><img alt="Research paper thumbnail of Preoperative and postoperative functional magnetic resonance imaging and intraoperative assessment of mental spatial transformations in patients undergoing surgery for brain tumors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025535/Preoperative_and_postoperative_functional_magnetic_resonance_imaging_and_intraoperative_assessment_of_mental_spatial_transformations_in_patients_undergoing_surgery_for_brain_tumors">Preoperative and postoperative functional magnetic resonance imaging and intraoperative assessment of mental spatial transformations in patients undergoing surgery for brain tumors</a></div><div class="wp-workCard_item"><span>Brain Mapping</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025535"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025535"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025535; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4937783" id="papers"><div class="js-work-strip profile--work_container" data-work-id="113442391"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442391/The_importance_of_cell_density_in_the_interpretation_of_growth_factor_effects_on_collagenase_IV_activity_release_and_extracellular_matrix_production_from_C6_astrocytoma_cells"><img alt="Research paper thumbnail of The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells" class="work-thumbnail" src="https://attachments.academia-assets.com/110399748/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442391/The_importance_of_cell_density_in_the_interpretation_of_growth_factor_effects_on_collagenase_IV_activity_release_and_extracellular_matrix_production_from_C6_astrocytoma_cells">The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells</a></div><div class="wp-workCard_item"><span>Journal of Neuro-oncology</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have examined the influence of basic fibroblast growth factor (FGF-2) and vascular endothelial...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have examined the influence of basic fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF) on the release of collagenase type IV activity and the production of extracellular matrix (ECM) molecules using C6 astrocytoma cells in monolayer culture. Collagenase type IV activity was significantly increased in a dose dependent manner in the low cell density group by treatment</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="252101d4b0a3b29dfcf3973d6c7e9358" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399748,"asset_id":113442391,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399748/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442391"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442391"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442391; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442391]").text(description); $(".js-view-count[data-work-id=113442391]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442391; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442391']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442391, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "252101d4b0a3b29dfcf3973d6c7e9358" } } $('.js-work-strip[data-work-id=113442391]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442391,"title":"The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells","translated_title":"","metadata":{"abstract":"We have examined the influence of basic fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF) on the release of collagenase type IV activity and the production of extracellular matrix (ECM) molecules using C6 astrocytoma cells in monolayer culture. 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113442390"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442390/Effects_of_Surgical_Excision_and_Radiation_on_Medulloblastoma_Cell_Invasiveness"><img alt="Research paper thumbnail of Effects of Surgical Excision and Radiation on Medulloblastoma Cell Invasiveness" class="work-thumbnail" src="https://attachments.academia-assets.com/110399724/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442390/Effects_of_Surgical_Excision_and_Radiation_on_Medulloblastoma_Cell_Invasiveness">Effects of Surgical Excision and Radiation on Medulloblastoma Cell Invasiveness</a></div><div class="wp-workCard_item"><span>Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives:Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patien...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives:Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patient management. We utilized a novel 3-dimensional assay to identify how (a) radiation, (b) excision of the primary tumour aggregate, and (c) both treatments combined influence MB cell invasiveness.Methods:Five MB cell lines (UW228-1, 2 and 3; Daoy, and Madsen) were implanted onto a 3-dimensional, type I collagen gel assay to assess tumour invasion distance over five days, in response to (1) needle-assisted excision of the central cell aggregate; (2) pre-exposure to single-dose and fractionated dose irradiation in doses from 6-25 and 8-24 Gy, respectively; and (3) excision plus either single-dose or fractionated radiation.Results:Within hours, individual MB cells detached from the surface of the cell aggregates and invaded the collagen matrix, to distances up to 1200 μm and at rates up to 300 μm daily. The UW228-1 cell line was less invasive than the other cell lines and was dropped from fu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7c65150f7278961fb4585e9be2073fd8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399724,"asset_id":113442390,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399724/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442390"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442390; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442390]").text(description); $(".js-view-count[data-work-id=113442390]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442390; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442390']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442390, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7c65150f7278961fb4585e9be2073fd8" } } $('.js-work-strip[data-work-id=113442390]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442390,"title":"Effects of Surgical Excision and Radiation on Medulloblastoma Cell Invasiveness","translated_title":"","metadata":{"abstract":"Objectives:Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patient management. We utilized a novel 3-dimensional assay to identify how (a) radiation, (b) excision of the primary tumour aggregate, and (c) both treatments combined influence MB cell invasiveness.Methods:Five MB cell lines (UW228-1, 2 and 3; Daoy, and Madsen) were implanted onto a 3-dimensional, type I collagen gel assay to assess tumour invasion distance over five days, in response to (1) needle-assisted excision of the central cell aggregate; (2) pre-exposure to single-dose and fractionated dose irradiation in doses from 6-25 and 8-24 Gy, respectively; and (3) excision plus either single-dose or fractionated radiation.Results:Within hours, individual MB cells detached from the surface of the cell aggregates and invaded the collagen matrix, to distances up to 1200 μm and at rates up to 300 μm daily. The UW228-1 cell line was less invasive than the other cell lines and was dropped from fu...","publisher":"Cambridge University Press (CUP)","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques"},"translated_abstract":"Objectives:Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patient management. We utilized a novel 3-dimensional assay to identify how (a) radiation, (b) excision of the primary tumour aggregate, and (c) both treatments combined influence MB cell invasiveness.Methods:Five MB cell lines (UW228-1, 2 and 3; Daoy, and Madsen) were implanted onto a 3-dimensional, type I collagen gel assay to assess tumour invasion distance over five days, in response to (1) needle-assisted excision of the central cell aggregate; (2) pre-exposure to single-dose and fractionated dose irradiation in doses from 6-25 and 8-24 Gy, respectively; and (3) excision plus either single-dose or fractionated radiation.Results:Within hours, individual MB cells detached from the surface of the cell aggregates and invaded the collagen matrix, to distances up to 1200 μm and at rates up to 300 μm daily. The UW228-1 cell line was less invasive than the other cell lines and was dropped from 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href="https://www.academia.edu/113442389/Pineal_Apoplexy_Imaging_Diagnosis_and_Follow_up_of_Three_New_Cases"><img alt="Research paper thumbnail of Pineal Apoplexy: Imaging Diagnosis and Follow-up of Three New Cases" class="work-thumbnail" src="https://attachments.academia-assets.com/110399743/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442389/Pineal_Apoplexy_Imaging_Diagnosis_and_Follow_up_of_Three_New_Cases">Pineal Apoplexy: Imaging Diagnosis and Follow-up of Three New Cases</a></div><div class="wp-workCard_item"><span>The Canadian Journal of Neurological Sciences</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cabb5417833c2a3a6029f85256ada267" class="wp-workCard--action" 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113442389, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cabb5417833c2a3a6029f85256ada267" } } $('.js-work-strip[data-work-id=113442389]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442389,"title":"Pineal Apoplexy: Imaging Diagnosis and Follow-up of Three New Cases","translated_title":"","metadata":{"publisher":"Cambridge University Press (CUP)","grobid_abstract":"Cystic lesions on the pineal gland are a common phenomenon, being found on up to 40% of autopsy cases 1. However, symptomatology as a result of these cysts is considerably rare. Mukherjee, Banerji and Sharma identified 74 cases in the literature 1. Symptomatic pineal cysts present as one of three syndromes identified by Wisoff and Epstein 2 : (1) paroxysmal headache with gaze paresis, (2) chronic headache, gaze paresis, papilledema and hydrocephalus, and (3) pineal apoplexy with acute hydrocephalus. Pineal apoplexy is understood as an acute presentation of hemorrhage within a pineal cystic lesion. Of the three syndromes pineal apoplexy is the rarest and while poorly understood, can have the most catastrophic of consequences, resulting in sudden death 3. Herein we report three cases with clinical and imaging findings suggestive of pineal gland apoplexy in the context of a discussion of the relevant literature.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"The Canadian Journal of Neurological Sciences","grobid_abstract_attachment_id":110399743},"translated_abstract":null,"internal_url":"https://www.academia.edu/113442389/Pineal_Apoplexy_Imaging_Diagnosis_and_Follow_up_of_Three_New_Cases","translated_internal_url":"","created_at":"2024-01-13T11:57:24.522-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110399743,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399743/thumbnails/1.jpg","file_name":"div-class-title-pineal-apoplexy-imaging-diagnosis-and-follow-up-of-three-new-cases-div.pdf","download_url":"https://www.academia.edu/attachments/110399743/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Pineal_Apoplexy_Imaging_Diagnosis_and_Fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399743/div-class-title-pineal-apoplexy-imaging-diagnosis-and-follow-up-of-three-new-cases-div-libre.pdf?1705176154=\u0026response-content-disposition=attachment%3B+filename%3DPineal_Apoplexy_Imaging_Diagnosis_and_Fo.pdf\u0026Expires=1732807501\u0026Signature=aXtCUlN~sh74RUxx2K4zJmba6~yRybn4lH30XI7cXd501teER5seajDvlW8Ug-7BB9kZQfHiDn0aEmsrmlVQkLZZuvUuwbo30HzoplGzEPZy-5JxFDrBc48KsPzaSHlmZWkvzVzYI9Pqqc3m713hJw1jusxr9ABAKcOF9SFY6Ycldtc8xe1t6pw0~2TyI8KGKLetM~7bEwO6TlXV5~v9GZbU6USPXkmE1TghKSYZsTAHFQooLmyTDEm5rvV0z~bEVFpd~048Pr2a0~6YfFru41oST02paJ0L9gIkYhPR533j4Pmhy-4keUjnvswlyLIhdIx0o8zbKHmX88fATxco3A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Pineal_Apoplexy_Imaging_Diagnosis_and_Follow_up_of_Three_New_Cases","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":110399743,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399743/thumbnails/1.jpg","file_name":"div-class-title-pineal-apoplexy-imaging-diagnosis-and-follow-up-of-three-new-cases-div.pdf","download_url":"https://www.academia.edu/attachments/110399743/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Pineal_Apoplexy_Imaging_Diagnosis_and_Fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399743/div-class-title-pineal-apoplexy-imaging-diagnosis-and-follow-up-of-three-new-cases-div-libre.pdf?1705176154=\u0026response-content-disposition=attachment%3B+filename%3DPineal_Apoplexy_Imaging_Diagnosis_and_Fo.pdf\u0026Expires=1732807501\u0026Signature=aXtCUlN~sh74RUxx2K4zJmba6~yRybn4lH30XI7cXd501teER5seajDvlW8Ug-7BB9kZQfHiDn0aEmsrmlVQkLZZuvUuwbo30HzoplGzEPZy-5JxFDrBc48KsPzaSHlmZWkvzVzYI9Pqqc3m713hJw1jusxr9ABAKcOF9SFY6Ycldtc8xe1t6pw0~2TyI8KGKLetM~7bEwO6TlXV5~v9GZbU6USPXkmE1TghKSYZsTAHFQooLmyTDEm5rvV0z~bEVFpd~048Pr2a0~6YfFru41oST02paJ0L9gIkYhPR533j4Pmhy-4keUjnvswlyLIhdIx0o8zbKHmX88fATxco3A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":293670,"name":"Pituitary Gland","url":"https://www.academia.edu/Documents/in/Pituitary_Gland"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113442388"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442388/Effect_of_ibuprofen_on_tumor_growth_in_the_C6_spheroid_implantation_glioma_model"><img alt="Research paper thumbnail of Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442388/Effect_of_ibuprofen_on_tumor_growth_in_the_C6_spheroid_implantation_glioma_model">Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model</a></div><div class="wp-workCard_item"><span>Journal of Neurosurgery</span><span>, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">✓ The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were ass...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">✓ The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats. The rats were treated with ibuprofen (24 mg/kg/day or 96 mg/kg/day) for 24 hours before implantation of C6 astrocytoma spheroids and then for 13 days following implantation. The wet and dry weight of the tumors and protein extravasation were measured by an Evans blue dye technique. Protein extravasation did not appear to be reduced by the treatments when assessed on the basis of tumor dry weight. The treatment significantly reduced the wet weight of the tumors in rats treated with high-dose and low-dose ibuprofen when compared to tumor wet weights in untreated rats. High-dose ibuprofen treatment significantly decreased the dry weight of the tumors compared to that of tumors in untreated control animals. It is hypothesized that the ibuprofen treatment regimen employed inhibits prostaglandin-associated angiogenesis induced by the C6 tumor cell growth and/or...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442388"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442388"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442388; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442388]").text(description); $(".js-view-count[data-work-id=113442388]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442388; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442388']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442388, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113442388]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442388,"title":"Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model","translated_title":"","metadata":{"abstract":"✓ The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats. The rats were treated with ibuprofen (24 mg/kg/day or 96 mg/kg/day) for 24 hours before implantation of C6 astrocytoma spheroids and then for 13 days following implantation. The wet and dry weight of the tumors and protein extravasation were measured by an Evans blue dye technique. Protein extravasation did not appear to be reduced by the treatments when assessed on the basis of tumor dry weight. The treatment significantly reduced the wet weight of the tumors in rats treated with high-dose and low-dose ibuprofen when compared to tumor wet weights in untreated rats. High-dose ibuprofen treatment significantly decreased the dry weight of the tumors compared to that of tumors in untreated control animals. It is hypothesized that the ibuprofen treatment regimen employed inhibits prostaglandin-associated angiogenesis induced by the C6 tumor cell growth and/or...","publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","publication_date":{"day":null,"month":null,"year":1988,"errors":{}},"publication_name":"Journal of Neurosurgery"},"translated_abstract":"✓ The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats. The rats were treated with ibuprofen (24 mg/kg/day or 96 mg/kg/day) for 24 hours before implantation of C6 astrocytoma spheroids and then for 13 days following implantation. The wet and dry weight of the tumors and protein extravasation were measured by an Evans blue dye technique. Protein extravasation did not appear to be reduced by the treatments when assessed on the basis of tumor dry weight. The treatment significantly reduced the wet weight of the tumors in rats treated with high-dose and low-dose ibuprofen when compared to tumor wet weights in untreated rats. High-dose ibuprofen treatment significantly decreased the dry weight of the tumors compared to that of tumors in untreated control animals. It is hypothesized that the ibuprofen treatment regimen employed inhibits prostaglandin-associated angiogenesis induced by the C6 tumor cell growth and/or...","internal_url":"https://www.academia.edu/113442388/Effect_of_ibuprofen_on_tumor_growth_in_the_C6_spheroid_implantation_glioma_model","translated_internal_url":"","created_at":"2024-01-13T11:57:24.310-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_ibuprofen_on_tumor_growth_in_the_C6_spheroid_implantation_glioma_model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[],"research_interests":[{"id":650,"name":"Neurosurgery","url":"https://www.academia.edu/Documents/in/Neurosurgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38650,"name":"Cell Division","url":"https://www.academia.edu/Documents/in/Cell_Division"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":83972,"name":"Permeability","url":"https://www.academia.edu/Documents/in/Permeability"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":284339,"name":"Ibuprofen","url":"https://www.academia.edu/Documents/in/Ibuprofen"},{"id":1178162,"name":"Tumor Growth","url":"https://www.academia.edu/Documents/in/Tumor_Growth"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":3693750,"name":"Extravasation","url":"https://www.academia.edu/Documents/in/Extravasation"}],"urls":[{"id":38532193,"url":"https://thejns.org/downloadpdf/journals/j-neurosurg/68/6/article-p925.xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113442387"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442387/Effects_of_steroids_and_nonsteroid_anti_inflammatory_agents_on_vascular_permeability_in_a_rat_glioma_model"><img alt="Research paper thumbnail of Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model" class="work-thumbnail" src="https://attachments.academia-assets.com/110399744/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442387/Effects_of_steroids_and_nonsteroid_anti_inflammatory_agents_on_vascular_permeability_in_a_rat_glioma_model">Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model</a></div><div class="wp-workCard_item"><span>Journal of Neurosurgery</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">✓ Cerebral edema produced by brain tumors is clinically and experimentally reduced by steroid the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">✓ Cerebral edema produced by brain tumors is clinically and experimentally reduced by steroid therapy. Nonsteroid anti-inflammatory drugs (NSAID&#39;s) which have been used to treat non-neural inflammation and swelling have not been evaluated for their ability to affect edema produced by brain tumors. The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID&#39;s (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas. Evans blue dye was used as a marker for serum albumin extravasation. The concentration of Evans blue dye was measured in the tumor and peritumoral and contralateral brain tissue 1 hour after intravenous injection. Extravasation of Evans blue dye within the tumor was decreased in all treatment groups when compared to placebo-injected control animals. The differences between the control specimens and those treated with dexamethasone, methyl...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e36462010554d569e2345530a45e57eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399744,"asset_id":113442387,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399744/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442387"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442387"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442387; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442387]").text(description); $(".js-view-count[data-work-id=113442387]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442387; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442387']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442387, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e36462010554d569e2345530a45e57eb" } } $('.js-work-strip[data-work-id=113442387]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442387,"title":"Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model","translated_title":"","metadata":{"abstract":"✓ Cerebral edema produced by brain tumors is clinically and experimentally reduced by steroid therapy. Nonsteroid anti-inflammatory drugs (NSAID\u0026#39;s) which have been used to treat non-neural inflammation and swelling have not been evaluated for their ability to affect edema produced by brain tumors. The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID\u0026#39;s (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas. Evans blue dye was used as a marker for serum albumin extravasation. The concentration of Evans blue dye was measured in the tumor and peritumoral and contralateral brain tissue 1 hour after intravenous injection. Extravasation of Evans blue dye within the tumor was decreased in all treatment groups when compared to placebo-injected control animals. The differences between the control specimens and those treated with dexamethasone, methyl...","publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","publication_date":{"day":null,"month":null,"year":1986,"errors":{}},"publication_name":"Journal of Neurosurgery"},"translated_abstract":"✓ Cerebral edema produced by brain tumors is clinically and experimentally reduced by steroid therapy. Nonsteroid anti-inflammatory drugs (NSAID\u0026#39;s) which have been used to treat non-neural inflammation and swelling have not been evaluated for their ability to affect edema produced by brain tumors. The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID\u0026#39;s (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas. Evans blue dye was used as a marker for serum albumin extravasation. The concentration of Evans blue dye was measured in the tumor and peritumoral and contralateral brain tissue 1 hour after intravenous injection. Extravasation of Evans blue dye within the tumor was decreased in all treatment groups when compared to placebo-injected control animals. The differences between the control specimens and those treated with dexamethasone, methyl...","internal_url":"https://www.academia.edu/113442387/Effects_of_steroids_and_nonsteroid_anti_inflammatory_agents_on_vascular_permeability_in_a_rat_glioma_model","translated_internal_url":"","created_at":"2024-01-13T11:57:24.115-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110399744,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399744/thumbnails/1.jpg","file_name":"b61270e6beaa998673e0eb4cb382ceb3e4a5.pdf","download_url":"https://www.academia.edu/attachments/110399744/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_steroids_and_nonsteroid_anti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399744/b61270e6beaa998673e0eb4cb382ceb3e4a5-libre.pdf?1705176161=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_steroids_and_nonsteroid_anti.pdf\u0026Expires=1732807501\u0026Signature=BXhrfNEtVItbHpOFZRnh1ihc8AtfD7rxonk8enhuvDKPS5o2rs~A1dLXSwVdjgdgIudvtE5W5E3HO7OrADw6b6q1oaVZaDKPDKKlshJpz30NgiznSkUOuO9ke4ILqEDZb4XVMGMuODl1S2AI6zwg9i3s9Q3ugONnK1IyPFuskZjMe9ivH51VhxEwsvZALgobF9Xhi3Rk2X8rBxHoqjw41IPs1gpxyCsDRlwgXib~SkSG50JtfE-yNEnHklF3mqOZ9I26aPup6eoIP3iDUjQyoVazWafKhnthswStf8K222EQZys5-Mt8c3iLAEzbCsG1HgZelMkohG8BIY8xizctPA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effects_of_steroids_and_nonsteroid_anti_inflammatory_agents_on_vascular_permeability_in_a_rat_glioma_model","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442386/A_new_glioma_model_in_rat_The_C6_spheroid_implantation_technique_permeability_and_vascular_characterization"><img alt="Research paper thumbnail of A new glioma model in rat: The C6 spheroid implantation technique permeability and vascular characterization" class="work-thumbnail" src="https://attachments.academia-assets.com/110399752/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442386/A_new_glioma_model_in_rat_The_C6_spheroid_implantation_technique_permeability_and_vascular_characterization">A new glioma model in rat: The C6 spheroid implantation technique permeability and vascular characterization</a></div><div class="wp-workCard_item"><span>Journal of Neuro-Oncology</span><span>, 1987</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="64c81eb60b69567afd05fb9b23d398ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399752,"asset_id":113442386,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399752/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442386"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span 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This report describes the growth, histology, vessel architecture and vascular permeability of the resulting tumors. The appearance of the tumor was investigated by light and electron microscopy, and by using the alkaline phosphatase technique. The leakage of tracer was measured from vessels in the tumor and peritumoral area at various times during tumor development. The spheroid implant produces a fully vascularized, rapidly growing tumor with many of the characteristics of glioblastoma multiforme, from an avascular focus of neoplastic cells. The major advantage of this model is that the tumors grow in a spheroidal fashion and the tumor-brain interface can be easily located. Many of the important events in the process of vascularization take place at the tumor-brain interface. Two distinctive vascular events appear to occur simultaneously: 1) proliferation of blood vessels and their growth into the tumor mass so that they develop into typical, permeable tumor vessels, and 2) migration of tumor cells along normal vessels into the surrounding brain. Tumor vessels were permeable to the tracer Evans Blue (EB) from the earliest days of ingrowth. Leakage of the EB increased as the tumors increased in size, but eventually leakage plateaued as tumors developed necrotic centers. It is well known that the structural and permeability characteristics of vessels associated with the tumor affect tumor growth. This model will be useful for a number of proposed studies including assessment of various clinical therapies on tumor growth and development, and more specifically, quantitative analysis of the vascularization process in tumors.","publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"Journal of 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data-work-id="113442385"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442385/Accelerated_Hypofractionated_Intensity_Modulated_Radiotherapy_With_Concurrent_and_Adjuvant_Temozolomide_for_Patients_With_Glioblastoma_Multiforme_A_Safety_and_Efficacy_Analysis"><img alt="Research paper thumbnail of Accelerated Hypofractionated Intensity-Modulated Radiotherapy With Concurrent and Adjuvant Temozolomide for Patients With Glioblastoma Multiforme: A Safety and Efficacy Analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/110399749/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442385/Accelerated_Hypofractionated_Intensity_Modulated_Radiotherapy_With_Concurrent_and_Adjuvant_Temozolomide_for_Patients_With_Glioblastoma_Multiforme_A_Safety_and_Efficacy_Analysis">Accelerated Hypofractionated Intensity-Modulated Radiotherapy With Concurrent and Adjuvant Temozolomide for Patients With Glioblastoma Multiforme: A Safety and Efficacy Analysis</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Oncology*Biology*Physics</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ed7d84ae3443d97828f92655194662cc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399749,"asset_id":113442385,"asset_type":"Work","button_location":"profile"}" 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ed7d84ae3443d97828f92655194662cc" } } $('.js-work-strip[data-work-id=113442385]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113442385,"title":"Accelerated Hypofractionated Intensity-Modulated Radiotherapy With Concurrent and Adjuvant Temozolomide for Patients With Glioblastoma Multiforme: A Safety and Efficacy Analysis","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"6 mg/m 2 q3wk cohort, and one DLT (pneumonia/infection without neutropenia) in six patients treated at 8 mg/m 2 q3wk. In the subsequent dose level (10 mg/m 2 q3wk), two DLT's occurred among four treated patients: one patient with renal failure and one patient with fatal pulmonary hemorrhage (the latter DLT was probably more likely related to underlying tumor than study treatment but a possible relationship can not be ruled out). It was decided to consider 8 mg/m 2 q3wk the MTD and future recommended phase II dose. Two patients (out of four evaluable patients) in this dose level had partial responses. Conclusions: With palliative fractionated brain radiotherapy (minimum 37.5 Gy), concurrent patupilone can be given at 8 mg/m 2 q3wk; this regimen is feasible for Phase II study.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"International Journal of Radiation 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the blood-brain barrier (B-BB). The vascular ultrastructural changes that underlie edema formation have been described in a variety of tumors. Interendothelial junction abnormalities, fenestrations, and large numbers of tubulo-vesicular profiles in the tumor vascular endothelium have been presumed to represent permeability routes that permit the escape of serum constituents into the tumor, from where they flow into the surrounding brain. Descriptive studies do not provide information on the relative frequency of these presumptive permeability routes. In the study reported here we have quantified ultrastructural features associated with the B-BB in the vessels of an experimental glioma in rat. We found that approximately 60% of the tumor vessel profiles have junctional abnormalities and 30% have one or more fenestrations. The density of tubulo-vesicular profiles, however, was not increased. In addition, tumor vessel walls were thicker than normal vessels of the same caliber and the mitochondrial density was in the range of that for non-barrier vessels. Vessels in peritumoral regions were not altered in any of the parameters measured.","publication_date":{"day":null,"month":null,"year":1985,"errors":{}},"publication_name":"Acta Neuropathologica","grobid_abstract_attachment_id":110399742},"translated_abstract":null,"internal_url":"https://www.academia.edu/113442384/A_quantitative_study_of_blood_brain_barrier_permeability_ultrastructure_in_a_new_rat_glioma_model","translated_internal_url":"","created_at":"2024-01-13T11:57:23.522-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110399742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399742/thumbnails/1.jpg","file_name":"BF00688129.pdf","download_url":"https://www.academia.edu/attachments/110399742/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_quantitative_study_of_blood_brain_barr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399742/BF00688129-libre.pdf?1705176154=\u0026response-content-disposition=attachment%3B+filename%3DA_quantitative_study_of_blood_brain_barr.pdf\u0026Expires=1732807502\u0026Signature=gUa0o~JFqL~qJv0p-Fcow95F3VvwqHDUn19Dr3v-Vsq0vqth3kGVbyvhhgI4T1wvOXKUhgtH7JAqb4AP9WrzaICNmtITKK-xnQjAt7Xiu3aYelkxGwHTDFa0fTK~OltcbzobWe21Qw4Gy7hI8qExYXzVMJCZWW3EIv2ut0BrMSIwDOQ5P7pF74kvFK~6YkTJ8YtqCgyZw-wHHUhRcy59kxDm4QB2im-FeGZIkhiiF1xdmhFBTMewS6MCRPRahrMj-H5yHtGKOiJUXeJm~hMJ7pv955hJ2swTl6uZNtjmkncDxWFRfoPoKhDrP0tNSM8G5H9LtjcoZjkM0SbQa8Pq6A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_quantitative_study_of_blood_brain_barrier_permeability_ultrastructure_in_a_new_rat_glioma_model","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":110399742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399742/thumbnails/1.jpg","file_name":"BF00688129.pdf","download_url":"https://www.academia.edu/attachments/110399742/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_quantitative_study_of_blood_brain_barr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399742/BF00688129-libre.pdf?1705176154=\u0026response-content-disposition=attachment%3B+filename%3DA_quantitative_study_of_blood_brain_barr.pdf\u0026Expires=1732807502\u0026Signature=gUa0o~JFqL~qJv0p-Fcow95F3VvwqHDUn19Dr3v-Vsq0vqth3kGVbyvhhgI4T1wvOXKUhgtH7JAqb4AP9WrzaICNmtITKK-xnQjAt7Xiu3aYelkxGwHTDFa0fTK~OltcbzobWe21Qw4Gy7hI8qExYXzVMJCZWW3EIv2ut0BrMSIwDOQ5P7pF74kvFK~6YkTJ8YtqCgyZw-wHHUhRcy59kxDm4QB2im-FeGZIkhiiF1xdmhFBTMewS6MCRPRahrMj-H5yHtGKOiJUXeJm~hMJ7pv955hJ2swTl6uZNtjmkncDxWFRfoPoKhDrP0tNSM8G5H9LtjcoZjkM0SbQa8Pq6A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":15719,"name":"Mitochondria","url":"https://www.academia.edu/Documents/in/Mitochondria"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":98913,"name":"Blood brain barrier","url":"https://www.academia.edu/Documents/in/Blood_brain_barrier"},{"id":138877,"name":"Vascular endothelium","url":"https://www.academia.edu/Documents/in/Vascular_endothelium"},{"id":212476,"name":"Ultrastructure","url":"https://www.academia.edu/Documents/in/Ultrastructure"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":557543,"name":"Blood Vessels","url":"https://www.academia.edu/Documents/in/Blood_Vessels"},{"id":788667,"name":"ENDOTHELIUM","url":"https://www.academia.edu/Documents/in/ENDOTHELIUM"},{"id":1142512,"name":"Vascular Permeability","url":"https://www.academia.edu/Documents/in/Vascular_Permeability"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1251210,"name":"Blood Vessel","url":"https://www.academia.edu/Documents/in/Blood_Vessel"},{"id":1363401,"name":"Brain Edema","url":"https://www.academia.edu/Documents/in/Brain_Edema"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"}],"urls":[{"id":38532189,"url":"http://link.springer.com/content/pdf/10.1007/BF00688129.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113442309"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113442309/Suturing_Technique_and_the_Integrity_of_Dural_Closures_An_in_Vitro_Study"><img alt="Research paper thumbnail of Suturing Technique and the Integrity of Dural Closures: An in Vitro Study" class="work-thumbnail" src="https://attachments.academia-assets.com/110399716/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113442309/Suturing_Technique_and_the_Integrity_of_Dural_Closures_An_in_Vitro_Study">Suturing Technique and the Integrity of Dural Closures: An in Vitro Study</a></div><div class="wp-workCard_item"><span>Neurosurgery</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cca54bb777db4778dc172f84f6d1ae4d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110399716,"asset_id":113442309,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110399716/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113442309"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113442309"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113442309; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113442309]").text(description); $(".js-view-count[data-work-id=113442309]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113442309; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113442309']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113442309, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Nevertheless, for any given operator and type of suture, it is still not certain which suturing technique affords the most watertight dural closure. We have developed a laboratory model that allows us to compare the pressures at which dural closures leak when different suturing techniques are used. METHODS: Human cadaveric dura was secured to a glass cylinder filled with colored saline. By application of force to a bag of saline attached to the cylinder, the pressure at which sutured dural incisions leak can be recorded. Using this method, we have compared the closure of 2-cm dural incisions with 3-0 silk using the following techniques (10 per group): 1) interrupted simple, 2) running simple, 3) running locked, and 4) interrupted vertical mattress. We have also compared the closure of 1-ϫ 3-cm dural windows with cadaveric dura and 3-0 silk using the same suturing techniques (10 per group). RESULTS: The pressure at which 2-cm linear dural incisions leaked was significantly higher when they were closed with the interrupted simple suturing technique (P Ͻ 0.05). There was no significant difference among the different suturing techniques when they were used to close a 1-ϫ 3-cm dural window with a duraplasty. Overall, the pressures at which sutured linear dural incisions leaked were higher than the pressures at which sutured dural windows closed with duraplasties leaked. CONCLUSION: In the experimental model described, an interrupted simple suturing technique affords the most watertight dural closure for linear incisions, whereas no suturing technique proved advantageous for the closure of a duraplasty.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Neurosurgery","grobid_abstract_attachment_id":110399716},"translated_abstract":null,"internal_url":"https://www.academia.edu/113442309/Suturing_Technique_and_the_Integrity_of_Dural_Closures_An_in_Vitro_Study","translated_internal_url":"","created_at":"2024-01-13T11:55:51.708-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110399716,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399716/thumbnails/1.jpg","file_name":"01.neu.0000138441.07112.1b20240113-1-kdc6sp.pdf","download_url":"https://www.academia.edu/attachments/110399716/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Suturing_Technique_and_the_Integrity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399716/01.neu.0000138441.07112.1b20240113-1-kdc6sp-libre.pdf?1705176160=\u0026response-content-disposition=attachment%3B+filename%3DSuturing_Technique_and_the_Integrity_of.pdf\u0026Expires=1732807502\u0026Signature=VF7BiBfM0FmAavS3BtOzk12eyvXn59VajUA30MHNeYI21DYVVtkNiZJtFvi6CLWLjpWcxE4Awasfizik85HP7ye8khPiSQ915w7qebW4LZmINas-Bfy-bxoe1yTpW4ybIKLkb55mVh9ohvMvCCjoL~NID~48Yl0hXWEwxqGYG5cHcSVbkwFA34xhJzrGnpN2GFqV04tfTv9ADIzdG0ieEU4ds~OsK4nbXcOrti47yhczFo583h3TAY~Zdfu0HdA0Asimemu-jjd4bB9xkNJFLDEfXrwmzViyhvNUNK5nU6ecuzcWfR7Z9vMkC~WBKwRbtoGhCBN9q2Xzu9QsbgE1LQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Suturing_Technique_and_the_Integrity_of_Dural_Closures_An_in_Vitro_Study","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":110399716,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110399716/thumbnails/1.jpg","file_name":"01.neu.0000138441.07112.1b20240113-1-kdc6sp.pdf","download_url":"https://www.academia.edu/attachments/110399716/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Suturing_Technique_and_the_Integrity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110399716/01.neu.0000138441.07112.1b20240113-1-kdc6sp-libre.pdf?1705176160=\u0026response-content-disposition=attachment%3B+filename%3DSuturing_Technique_and_the_Integrity_of.pdf\u0026Expires=1732807502\u0026Signature=VF7BiBfM0FmAavS3BtOzk12eyvXn59VajUA30MHNeYI21DYVVtkNiZJtFvi6CLWLjpWcxE4Awasfizik85HP7ye8khPiSQ915w7qebW4LZmINas-Bfy-bxoe1yTpW4ybIKLkb55mVh9ohvMvCCjoL~NID~48Yl0hXWEwxqGYG5cHcSVbkwFA34xhJzrGnpN2GFqV04tfTv9ADIzdG0ieEU4ds~OsK4nbXcOrti47yhczFo583h3TAY~Zdfu0HdA0Asimemu-jjd4bB9xkNJFLDEfXrwmzViyhvNUNK5nU6ecuzcWfR7Z9vMkC~WBKwRbtoGhCBN9q2Xzu9QsbgE1LQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":650,"name":"Neurosurgery","url":"https://www.academia.edu/Documents/in/Neurosurgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":247948,"name":"Cadaver","url":"https://www.academia.edu/Documents/in/Cadaver"},{"id":280139,"name":"Suture","url":"https://www.academia.edu/Documents/in/Suture"},{"id":546400,"name":"Postoperative Hemorrhage","url":"https://www.academia.edu/Documents/in/Postoperative_Hemorrhage"},{"id":780594,"name":"In Vitro Studies","url":"https://www.academia.edu/Documents/in/In_Vitro_Studies"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications"},{"id":3123412,"name":"Cerebrospinal Fluid Leak Repair","url":"https://www.academia.edu/Documents/in/Cerebrospinal_Fluid_Leak_Repair"},{"id":3153703,"name":"Suture techniques","url":"https://www.academia.edu/Documents/in/Suture_techniques"},{"id":3996792,"name":"Dura mater","url":"https://www.academia.edu/Documents/in/Dura_mater"}],"urls":[{"id":38532170,"url":"http://academic.oup.com/neurosurgery/article-pdf/55/4/950/10971647/00006123-200410000-00032.pdf"}]}, dispatcherData: dispatcherData }); 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Achievements in these fields have been predominantly the results of advances in surgical techniques, medical and intensive-care methods.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80146522"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80146522"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80146522; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80146522]").text(description); $(".js-view-count[data-work-id=80146522]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80146522; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80146522']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80146522, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=80146522]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80146522,"title":"A free radical approach to tissue injury","translated_title":"","metadata":{"abstract":"Problems associated with hypoxic tissue damage emerge as central constraints in cardiovascular, neurosurgical and transplantation surgery. 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Supplementum</span><span>, 1980</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polymorphonuclear leukocytes and other inflammatory cells on exposure to appropriate stimuli rele...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polymorphonuclear leukocytes and other inflammatory cells on exposure to appropriate stimuli release superoxide anion radical into the extracellular space. This results in the further generation of other activated oxygen species such as hydrogen peroxide, hydroxyl radical and singlet oxygen. We have assessed the influence of activated oxygen species, generated by substrate-xanthine oxidase systems, on the degradation of hyaluronic acid, human glial cells in culture and the microcirculation of the hamster cheek pouch. Hyaluronic acid degradation was observed and morphological changes, culminating in cell death, were seen in glial cells. Increased microvascular permeability and increased polymorphonuclear leukocyte-endothelial adhesion were also observed. The results suggest that a variety of alterations to macromolecular and cellular elements of tissues can be mediated by specific free radical species. Similar mechanisms may play a role in the structural and cellular injury occurring...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="67349217"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="67349217"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67349217; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67349217]").text(description); $(".js-view-count[data-work-id=67349217]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67349217; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='67349217']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 67349217, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=67349217]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":67349217,"title":"Free radicals as mediators of tissue injury","translated_title":"","metadata":{"abstract":"Polymorphonuclear leukocytes and other inflammatory cells on exposure to appropriate stimuli release superoxide anion radical into the extracellular space. 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Supplementum","publication_date":{"day":null,"month":null,"year":1980,"errors":{}},"publication_name":"Acta physiologica Scandinavica. Supplementum"},"translated_abstract":"Polymorphonuclear leukocytes and other inflammatory cells on exposure to appropriate stimuli release superoxide anion radical into the extracellular space. This results in the further generation of other activated oxygen species such as hydrogen peroxide, hydroxyl radical and singlet oxygen. We have assessed the influence of activated oxygen species, generated by substrate-xanthine oxidase systems, on the degradation of hyaluronic acid, human glial cells in culture and the microcirculation of the hamster cheek pouch. Hyaluronic acid degradation was observed and morphological changes, culminating in cell death, were seen in glial cells. Increased microvascular permeability and increased polymorphonuclear leukocyte-endothelial adhesion were also observed. The results suggest that a variety of alterations to macromolecular and cellular elements of tissues can be mediated by specific free radical species. Similar mechanisms may play a role in the structural and cellular injury occurring...","internal_url":"https://www.academia.edu/67349217/Free_radicals_as_mediators_of_tissue_injury","translated_internal_url":"","created_at":"2022-01-06T02:20:39.770-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":5370266,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":37887392,"work_id":67349217,"tagging_user_id":5370266,"tagged_user_id":46086183,"co_author_invite_id":null,"email":"r***o@mcgill.ca","display_order":0,"name":"Rolando Maestro","title":"Free radicals as mediators of tissue injury"},{"id":37887393,"work_id":67349217,"tagging_user_id":5370266,"tagged_user_id":11242026,"co_author_invite_id":null,"email":"a***s@gmail.com","display_order":4194304,"name":"Karl E. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025540"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025540/Face_content_and_construct_validity_of_human_placenta_as_a_haptic_training_tool_in_neurointerventional_surgery"><img alt="Research paper thumbnail of Face, content, and construct validity of human placenta as a haptic training tool in neurointerventional surgery" class="work-thumbnail" src="https://attachments.academia-assets.com/75591477/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025540/Face_content_and_construct_validity_of_human_placenta_as_a_haptic_training_tool_in_neurointerventional_surgery">Face, content, and construct validity of human placenta as a haptic training tool in neurointerventional surgery</a></div><div class="wp-workCard_item"><span>Journal of neurosurgery</span><span>, Jan 9, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">OBJECT The development of neurointerventional treatments of central nervous system disorders has ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">OBJECT The development of neurointerventional treatments of central nervous system disorders has resulted in the need for adequate training environments for novice interventionalists. Virtual simulators offer anatomical definition but lack adequate tactile feedback. Animal models, which provide more lifelike training, require an appropriate infrastructure base. The authors describe a training model for neurointerventional procedures using the human placenta (HP), which affords haptic training with significantly fewer resource requirements, and discuss its validation. METHODS Twelve HPs were prepared for simulated endovascular procedures. Training exercises performed by interventional neuroradiologists and novice fellows were placental angiography, stent placement, aneurysm coiling, and intravascular liquid embolic agent injection. RESULTS The endovascular training exercises proposed can be easily reproduced in the HP. Face, content, and construct validity were assessed by 6 neuroint...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5faecf636f74343e0516b86a7f0359f8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75591477,"asset_id":63025540,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75591477/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025540"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025540"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025540; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025540]").text(description); $(".js-view-count[data-work-id=63025540]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025540; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025540']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025540, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5faecf636f74343e0516b86a7f0359f8" } } $('.js-work-strip[data-work-id=63025540]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025540,"title":"Face, content, and construct validity of human placenta as a haptic training tool in neurointerventional surgery","translated_title":"","metadata":{"abstract":"OBJECT The development of neurointerventional treatments of central nervous system disorders has resulted in the need for adequate training environments for novice interventionalists. Virtual simulators offer anatomical definition but lack adequate tactile feedback. Animal models, which provide more lifelike training, require an appropriate infrastructure base. The authors describe a training model for neurointerventional procedures using the human placenta (HP), which affords haptic training with significantly fewer resource requirements, and discuss its validation. METHODS Twelve HPs were prepared for simulated endovascular procedures. Training exercises performed by interventional neuroradiologists and novice fellows were placental angiography, stent placement, aneurysm coiling, and intravascular liquid embolic agent injection. RESULTS The endovascular training exercises proposed can be easily reproduced in the HP. 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Training exercises performed by interventional neuroradiologists and novice fellows were placental angiography, stent placement, aneurysm coiling, and intravascular liquid embolic agent injection. RESULTS The endovascular training exercises proposed can be easily reproduced in the HP. Face, content, and construct validity were assessed by 6 neuroint...","internal_url":"https://www.academia.edu/63025540/Face_content_and_construct_validity_of_human_placenta_as_a_haptic_training_tool_in_neurointerventional_surgery","translated_internal_url":"","created_at":"2021-12-02T14:27:58.666-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75591477,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591477/thumbnails/1.jpg","file_name":"3b8e55e5aed56f952803b7893266e2978b73.pdf","download_url":"https://www.academia.edu/attachments/75591477/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Face_content_and_construct_validity_of_h.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591477/3b8e55e5aed56f952803b7893266e2978b73-libre.pdf?1638487316=\u0026response-content-disposition=attachment%3B+filename%3DFace_content_and_construct_validity_of_h.pdf\u0026Expires=1732807502\u0026Signature=TjEeT-O2t7OhyhfrUYq~oFQBWjJp8UZNzjhn5pQhLr8C9g7D-vXl8dqFArtcfXYDe8f6UdeTYxkCsfJrGeAZ2om5RrCxd83ktACcALSEXI2168NSDnCcy7edwDsj-h9rNXewnI0wiVJk5oJIXrixcFL~QMaRykjxouIgMOcnBm1tnArmIjtkOkR6y5vRf5MgQkx5tkgSOQCdzhLXlF7mGCmRJxKDf3bBQariJ1-YX8mR3wU0Z-yMBBqM6zU~Bpe7biEIA6HvVOzNgv22ATaApC5QeMGdD3bTIMtH-T6y4B0g~9w3grga8dpEgWFlLIHpElrEYkllnUmaLTt9DgcYiQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Face_content_and_construct_validity_of_human_placenta_as_a_haptic_training_tool_in_neurointerventional_surgery","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":75591477,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591477/thumbnails/1.jpg","file_name":"3b8e55e5aed56f952803b7893266e2978b73.pdf","download_url":"https://www.academia.edu/attachments/75591477/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Face_content_and_construct_validity_of_h.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591477/3b8e55e5aed56f952803b7893266e2978b73-libre.pdf?1638487316=\u0026response-content-disposition=attachment%3B+filename%3DFace_content_and_construct_validity_of_h.pdf\u0026Expires=1732807502\u0026Signature=TjEeT-O2t7OhyhfrUYq~oFQBWjJp8UZNzjhn5pQhLr8C9g7D-vXl8dqFArtcfXYDe8f6UdeTYxkCsfJrGeAZ2om5RrCxd83ktACcALSEXI2168NSDnCcy7edwDsj-h9rNXewnI0wiVJk5oJIXrixcFL~QMaRykjxouIgMOcnBm1tnArmIjtkOkR6y5vRf5MgQkx5tkgSOQCdzhLXlF7mGCmRJxKDf3bBQariJ1-YX8mR3wU0Z-yMBBqM6zU~Bpe7biEIA6HvVOzNgv22ATaApC5QeMGdD3bTIMtH-T6y4B0g~9w3grga8dpEgWFlLIHpElrEYkllnUmaLTt9DgcYiQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":650,"name":"Neurosurgery","url":"https://www.academia.edu/Documents/in/Neurosurgery"},{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":247701,"name":"Angiography","url":"https://www.academia.edu/Documents/in/Angiography"},{"id":704648,"name":"Clinical Competence","url":"https://www.academia.edu/Documents/in/Clinical_Competence"},{"id":1205102,"name":"Cerebrovascular Disorders","url":"https://www.academia.edu/Documents/in/Cerebrovascular_Disorders"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1909338,"name":"Endovascular Procedures","url":"https://www.academia.edu/Documents/in/Endovascular_Procedures"},{"id":3208250,"name":"Intracranial aneurysm","url":"https://www.academia.edu/Documents/in/Intracranial_aneurysm"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025539"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025539/Face_Content_and_Construct_Validity_of_Brain_Tumor_Microsurgery_Simulation_Using_a_Human_Placenta_Model"><img alt="Research paper thumbnail of Face, Content, and Construct Validity of Brain Tumor Microsurgery Simulation Using a Human Placenta Model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025539/Face_Content_and_Construct_Validity_of_Brain_Tumor_Microsurgery_Simulation_Using_a_Human_Placenta_Model">Face, Content, and Construct Validity of Brain Tumor Microsurgery Simulation Using a Human Placenta Model</a></div><div class="wp-workCard_item"><span>Neurosurgery</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND Brain tumors are complex 3-dimensional lesions. Their resection involves training and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND Brain tumors are complex 3-dimensional lesions. Their resection involves training and the use of the multiple microsurgical techniques available for removal. Simulation models, with haptic and visual realism, may be useful for improving the bimanual technical skills of neurosurgical residents and neurosurgeons, potentially decreasing surgical errors and thus improving patient outcomes. OBJECTIVE To describe and assess an ex vivo placental model for brain tumor microsurgery using a simulation tool in neurosurgical psychomotor teaching and assessment. METHODS Sixteen human placentas were used in this research project. Intravascular blood remnants were removed by continuous saline solution irrigation of the 2 placental arteries and placental vein. Brain tumors were simulated using silicone injections in the placental stroma. Eight neurosurgeons and 8 neurosurgical residents carried out the resection of simulated tumors using the same surgical instruments and bimanual microsu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025539"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025539"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025539; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025539]").text(description); $(".js-view-count[data-work-id=63025539]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025539; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025539']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025539, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=63025539]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025539,"title":"Face, Content, and Construct Validity of Brain Tumor Microsurgery Simulation Using a Human Placenta Model","translated_title":"","metadata":{"abstract":"BACKGROUND Brain tumors are complex 3-dimensional lesions. Their resection involves training and the use of the multiple microsurgical techniques available for removal. Simulation models, with haptic and visual realism, may be useful for improving the bimanual technical skills of neurosurgical residents and neurosurgeons, potentially decreasing surgical errors and thus improving patient outcomes. OBJECTIVE To describe and assess an ex vivo placental model for brain tumor microsurgery using a simulation tool in neurosurgical psychomotor teaching and assessment. METHODS Sixteen human placentas were used in this research project. Intravascular blood remnants were removed by continuous saline solution irrigation of the 2 placental arteries and placental vein. Brain tumors were simulated using silicone injections in the placental stroma. Eight neurosurgeons and 8 neurosurgical residents carried out the resection of simulated tumors using the same surgical instruments and bimanual microsu...","publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Neurosurgery"},"translated_abstract":"BACKGROUND Brain tumors are complex 3-dimensional lesions. Their resection involves training and the use of the multiple microsurgical techniques available for removal. Simulation models, with haptic and visual realism, may be useful for improving the bimanual technical skills of neurosurgical residents and neurosurgeons, potentially decreasing surgical errors and thus improving patient outcomes. OBJECTIVE To describe and assess an ex vivo placental model for brain tumor microsurgery using a simulation tool in neurosurgical psychomotor teaching and assessment. METHODS Sixteen human placentas were used in this research project. Intravascular blood remnants were removed by continuous saline solution irrigation of the 2 placental arteries and placental vein. Brain tumors were simulated using silicone injections in the placental stroma. Eight neurosurgeons and 8 neurosurgical residents carried out the resection of simulated tumors using the same surgical instruments and bimanual microsu...","internal_url":"https://www.academia.edu/63025539/Face_Content_and_Construct_Validity_of_Brain_Tumor_Microsurgery_Simulation_Using_a_Human_Placenta_Model","translated_internal_url":"","created_at":"2021-12-02T14:27:58.552-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Face_Content_and_Construct_Validity_of_Brain_Tumor_Microsurgery_Simulation_Using_a_Human_Placenta_Model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[],"research_interests":[{"id":650,"name":"Neurosurgery","url":"https://www.academia.edu/Documents/in/Neurosurgery"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025538"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025538/Effects_of_radiation_on_a_model_of_malignant_glioma_invasion"><img alt="Research paper thumbnail of Effects of radiation on a model of malignant glioma invasion" class="work-thumbnail" src="https://attachments.academia-assets.com/75591482/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025538/Effects_of_radiation_on_a_model_of_malignant_glioma_invasion">Effects of radiation on a model of malignant glioma invasion</a></div><div class="wp-workCard_item"><span>Journal of neuro-oncology</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We sought to characterize the effects of radiation alone and in combination with BCNU and dexamet...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We sought to characterize the effects of radiation alone and in combination with BCNU and dexamethasone on malignant glioma invasion. A model of malignant glioma invasion into a gel matrix of collagen type I was used to characterize response to radiation treatment for four malignant glioma cell lines (C6, U251, U373, A172) and nine primary human glioblastoma explants. A radiation dose dependent inhibition of invasion was noted for the C6 astrocytoma cell line but not the other cell lines or explants. Addition of BCNU and dexamethasone to radiation produced additional inhibition of invasion among the cell lines and explants but could not suppress invasion entirely.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b5e0aea61b9f8a84d13cb4849744f8c1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75591482,"asset_id":63025538,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75591482/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025538"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025538"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025538; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025538]").text(description); $(".js-view-count[data-work-id=63025538]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025538; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025538']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025538, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b5e0aea61b9f8a84d13cb4849744f8c1" } } $('.js-work-strip[data-work-id=63025538]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025538,"title":"Effects of radiation on a model of malignant glioma invasion","translated_title":"","metadata":{"abstract":"We sought to characterize the effects of radiation alone and in combination with BCNU and dexamethasone on malignant glioma invasion. 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Addition of BCNU and dexamethasone to radiation produced additional inhibition of invasion among the cell lines and explants but could not suppress invasion entirely.","internal_url":"https://www.academia.edu/63025538/Effects_of_radiation_on_a_model_of_malignant_glioma_invasion","translated_internal_url":"","created_at":"2021-12-02T14:27:58.459-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46086183,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75591482,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591482/thumbnails/1.jpg","file_name":"a_3A100631941707720211202-8113-88diu9.pdf","download_url":"https://www.academia.edu/attachments/75591482/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_radiation_on_a_model_of_malig.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591482/a_3A100631941707720211202-8113-88diu9-libre.pdf?1638487308=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_radiation_on_a_model_of_malig.pdf\u0026Expires=1732807502\u0026Signature=bL0mV4GqA27Rhv2Q1KKqiWayufDHkPtRuOAsekBP38JXFqikgkNJyFJbqk~DceuI5O7EEp7MRWsctCJ2FL9jTjuYuQEoprmtmIT3VZ48MSTyP2x451g134gcBw88XOgyLXcris8ETIgSechEEqztwxB9JU71LkOGvF~f9iVcUBdWuQh9w-LQ8xZx1ssDWp6-~uXyeq~rpXDVdbidGjNkzs91HT0AxkFs5-aoO7ecC9AgPXe8WG~TlDj-GoMSPOsdx79KmckhwtbGMn6Nwii~0c-1NP5pRFMxeiiSiK9caeFV27UDo~QXyr1PGTa3xyD5MUuPMlsBcaNXu~eEf46nZg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effects_of_radiation_on_a_model_of_malignant_glioma_invasion","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":46086183,"first_name":"Rolando","middle_initials":null,"last_name":"Maestro","page_name":"RolandoMaestro","domain_name":"independent","created_at":"2016-03-30T14:14:03.693-07:00","display_name":"Rolando Maestro","url":"https://independent.academia.edu/RolandoMaestro"},"attachments":[{"id":75591482,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75591482/thumbnails/1.jpg","file_name":"a_3A100631941707720211202-8113-88diu9.pdf","download_url":"https://www.academia.edu/attachments/75591482/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_radiation_on_a_model_of_malig.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75591482/a_3A100631941707720211202-8113-88diu9-libre.pdf?1638487308=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_radiation_on_a_model_of_malig.pdf\u0026Expires=1732807503\u0026Signature=gq-7ZScuDxzHnjwsSFZvt9tM3FEv0yBjDK~xnPFxGJIss0f6RyP~0h6yakj~L0So2m81dgZuMKMM~UO4CXPRRGVu3GRLzbi~mT~GWhNtTW7U1y9Pj2O6O6D3HeQ22fSsaFeX4DwiFexeFSx5NfKyhDU9mBRbUDCa2YDw2VsOShagk4JClNl3PtNmz9q8xXDsPXCYTgQfCl0zCpilqYW-bqqYdiNymQrAQLfwnbKKl4dZbZdtqV5KZJlDJRYEIHsoaOfqtI2uC3HLW4ntjQT62V2gnd5trL1eB72bKRWD67BlzCd4hHHybXpsJDnL9AL1O7IsT9tBR9gObLTurSTRUQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":57801,"name":"Dexamethasone","url":"https://www.academia.edu/Documents/in/Dexamethasone"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":91499,"name":"Glioblastoma","url":"https://www.academia.edu/Documents/in/Glioblastoma"},{"id":127604,"name":"Neuro","url":"https://www.academia.edu/Documents/in/Neuro"},{"id":371494,"name":"Neoplasm Invasiveness","url":"https://www.academia.edu/Documents/in/Neoplasm_Invasiveness"},{"id":389506,"name":"Radiation Dose","url":"https://www.academia.edu/Documents/in/Radiation_Dose"},{"id":573989,"name":"Malignant Glioma","url":"https://www.academia.edu/Documents/in/Malignant_Glioma"},{"id":859051,"name":"Astrocytoma","url":"https://www.academia.edu/Documents/in/Astrocytoma"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025537"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025537/Radiation_induced_cavernous_hemangiomas_case_report_and_literature_review"><img alt="Research paper thumbnail of Radiation-induced cavernous hemangiomas: case report and literature review" class="work-thumbnail" src="https://attachments.academia-assets.com/75591484/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025537/Radiation_induced_cavernous_hemangiomas_case_report_and_literature_review">Radiation-induced cavernous hemangiomas: case report and literature review</a></div><div class="wp-workCard_item"><span>The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cranial irradiation for a cerebellar astrocytoma is reported. A review of 84 cases of radiation-induced cavernous hemangiomas found in the literature is presented. In this series the mean age at the time of irradiation (+/- SD) was 10.4 +/- 2.0 years (median = 8 years), while the mean time to cavernous hemangioma diagnosis (+/- SD) was 10.3 +/- 1.9 years (median = 8 years). Time to cavernous hemangioma diagnosis was found to be inversely related to radiation dose. Hemorrhage from radiation-induced cavernous hemangiomas was found in 40.0% of patients, with an incidence of 3.9% per patient year. An inverse trend was identified between radiation dose and symptomatic presentation, cavernous hemangioma hemorrhage or surgical resection. This review of radiation-induced cavernous hemangiomas confirms that both younger patients and those who received a larger dose of radiation are at increased ris...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b187511dda47851a810070c2b776b8a7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75591484,"asset_id":63025537,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75591484/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025537"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025537"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025537; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025537]").text(description); $(".js-view-count[data-work-id=63025537]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025537; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025537']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025537, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b187511dda47851a810070c2b776b8a7" } } $('.js-work-strip[data-work-id=63025537]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025537,"title":"Radiation-induced cavernous hemangiomas: case report and literature review","translated_title":"","metadata":{"abstract":"The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cranial irradiation for a cerebellar astrocytoma is reported. A review of 84 cases of radiation-induced cavernous hemangiomas found in the literature is presented. In this series the mean age at the time of irradiation (+/- SD) was 10.4 +/- 2.0 years (median = 8 years), while the mean time to cavernous hemangioma diagnosis (+/- SD) was 10.3 +/- 1.9 years (median = 8 years). Time to cavernous hemangioma diagnosis was found to be inversely related to radiation dose. Hemorrhage from radiation-induced cavernous hemangiomas was found in 40.0% of patients, with an incidence of 3.9% per patient year. An inverse trend was identified between radiation dose and symptomatic presentation, cavernous hemangioma hemorrhage or surgical resection. This review of radiation-induced cavernous hemangiomas confirms that both younger patients and those who received a larger dose of radiation are at increased ris...","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques"},"translated_abstract":"The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cranial irradiation for a cerebellar astrocytoma is reported. A review of 84 cases of radiation-induced cavernous hemangiomas found in the literature is presented. In this series the mean age at the time of irradiation (+/- SD) was 10.4 +/- 2.0 years (median = 8 years), while the mean time to cavernous hemangioma diagnosis (+/- SD) was 10.3 +/- 1.9 years (median = 8 years). Time to cavernous hemangioma diagnosis was found to be inversely related to radiation dose. Hemorrhage from radiation-induced cavernous hemangiomas was found in 40.0% of patients, with an incidence of 3.9% per patient year. An inverse trend was identified between radiation dose and symptomatic presentation, cavernous hemangioma hemorrhage or surgical resection. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025536"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025536/Dynamics_of_C6_astrocytoma_invasion_into_three_dimensional_collagen_gels"><img alt="Research paper thumbnail of Dynamics of C6 astrocytoma invasion into three-dimensional collagen gels" class="work-thumbnail" src="https://attachments.academia-assets.com/75591519/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025536/Dynamics_of_C6_astrocytoma_invasion_into_three_dimensional_collagen_gels">Dynamics of C6 astrocytoma invasion into three-dimensional collagen gels</a></div><div class="wp-workCard_item"><span>Journal of neuro-oncology</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The dynamic mechanisms underlying the three-dimensional invasive paradigm of C6 astrocytoma cells...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The dynamic mechanisms underlying the three-dimensional invasive paradigm of C6 astrocytoma cells has been assessed. Spheroids of C6 astrocytoma cells were implanted into three-dimensional collagen type I gels (vitrogen 100) and individual C6 astrocytoma cell invasion monitored. Time-lapsed videomicroscopy was used to assess the dynamic components of cell invasion in three dimensions while scanning and transmission electron microscopy were used to assess matrix architecture and the static aspects of cell invasion. Videomicroscopy outlined an invasion paradigm continuum with repeating phases. A cell surface ruffling phase was followed by invadopodia extension and pull up phases. For some cells the collagen type I matrix extracellular matrix appeared to modify the ability of C6 cells to carry out their invasion paradigm. C6 astrocytoma cells invading a three-dimensional collagen type I matrix utilize a invasion paradigm made up of a number of phases. A better understanding of the dyna...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5fdbeda0e32bf032694c1ddb8ff3f6fb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75591519,"asset_id":63025536,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75591519/download_file?st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&st=MTczMjgwMzkwMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025536"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025536"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025536; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63025536]").text(description); $(".js-view-count[data-work-id=63025536]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63025536; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='63025536']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 63025536, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5fdbeda0e32bf032694c1ddb8ff3f6fb" } } $('.js-work-strip[data-work-id=63025536]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":63025536,"title":"Dynamics of C6 astrocytoma invasion into three-dimensional collagen gels","translated_title":"","metadata":{"abstract":"The dynamic mechanisms underlying the three-dimensional invasive paradigm of C6 astrocytoma cells has been assessed. Spheroids of C6 astrocytoma cells were implanted into three-dimensional collagen type I gels (vitrogen 100) and individual C6 astrocytoma cell invasion monitored. Time-lapsed videomicroscopy was used to assess the dynamic components of cell invasion in three dimensions while scanning and transmission electron microscopy were used to assess matrix architecture and the static aspects of cell invasion. Videomicroscopy outlined an invasion paradigm continuum with repeating phases. A cell surface ruffling phase was followed by invadopodia extension and pull up phases. For some cells the collagen type I matrix extracellular matrix appeared to modify the ability of C6 cells to carry out their invasion paradigm. C6 astrocytoma cells invading a three-dimensional collagen type I matrix utilize a invasion paradigm made up of a number of phases. A better understanding of the dyna...","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Journal of neuro-oncology"},"translated_abstract":"The dynamic mechanisms underlying the three-dimensional invasive paradigm of C6 astrocytoma cells has been assessed. Spheroids of C6 astrocytoma cells were implanted into three-dimensional collagen type I gels (vitrogen 100) and individual C6 astrocytoma cell invasion monitored. Time-lapsed videomicroscopy was used to assess the dynamic components of cell invasion in three dimensions while scanning and transmission electron microscopy were used to assess matrix architecture and the static aspects of cell invasion. Videomicroscopy outlined an invasion paradigm continuum with repeating phases. A cell surface ruffling phase was followed by invadopodia extension and pull up phases. For some cells the collagen type I matrix extracellular matrix appeared to modify the ability of C6 cells to carry out their invasion paradigm. C6 astrocytoma cells invading a three-dimensional collagen type I matrix utilize a invasion paradigm made up of a number of phases. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="63025535"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/63025535/Preoperative_and_postoperative_functional_magnetic_resonance_imaging_and_intraoperative_assessment_of_mental_spatial_transformations_in_patients_undergoing_surgery_for_brain_tumors"><img alt="Research paper thumbnail of Preoperative and postoperative functional magnetic resonance imaging and intraoperative assessment of mental spatial transformations in patients undergoing surgery for brain tumors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/63025535/Preoperative_and_postoperative_functional_magnetic_resonance_imaging_and_intraoperative_assessment_of_mental_spatial_transformations_in_patients_undergoing_surgery_for_brain_tumors">Preoperative and postoperative functional magnetic resonance imaging and intraoperative assessment of mental spatial transformations in patients undergoing surgery for brain tumors</a></div><div class="wp-workCard_item"><span>Brain Mapping</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="63025535"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="63025535"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63025535; 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