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class="sf-depth-3" title="Patients partner with our scientists to accelerate the pace of discovery and find better treatments.">Patient-partnered research <span class="sf-description">Patients partner with our scientists to accelerate the pace of discovery and find better treatments.</span></a></li><li id="header-menu-menu-link-content93f5c6b6-e25f-4dcf-940d-8cd0ebdaab9a" class="sf-depth-3 sf-no-children"><a href="/strategic-alliances-and-partnering" class="sf-depth-3" title="We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries.">Partnering and licensing <span class="sf-description">We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries.</span></a></li><li id="header-menu-menu-link-content40d899bd-29da-4415-816c-0381756261ac" class="sf-depth-3 sf-no-children"><a href="/publications" class="sf-depth-3" title="A catalog of scientific papers published by our 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class="sf-depth-2 sf-no-children"><a href="/gerstner-center-cancer-diagnostics" class="sf-depth-2" title="The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.">Gerstner Center for Cancer Diagnostics <span class="sf-description">The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.</span></a></li><li id="header-menu-menu-link-contenta1450e5b-1fbb-4d9e-85f7-e0df335ada8c" class="sf-depth-2 sf-no-children"><a href="/klarman-cell-observatory" class="sf-depth-2" title="The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.">Klarman Cell Observatory <span class="sf-description">The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.</span></a></li><li id="header-menu-menu-link-contentf919ca42-db45-41ce-8888-efe027a9fb36" class="sf-depth-2 sf-no-children"><a href="/merkin-institute-transformative-technologies-healthcare" class="sf-depth-2" title="The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.">Merkin Institute for Transformative Technologies in Healthcare <span class="sf-description">The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.</span></a></li><li id="header-menu-menu-link-contentb12c2ad1-a84c-455a-821e-59bfd482c758" class="sf-depth-2 sf-no-children"><a href="/nnfc" class="sf-depth-2" title="This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community.">Novo Nordisk Foundation Center for Genomic Mechanisms of Disease <span class="sf-description">This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community.</span></a></li><li id="header-menu-menu-link-content317da4e7-16de-4bbc-95da-f3ea10e0c178" class="sf-depth-2 sf-no-children"><a href="/ewsc" class="sf-depth-2" title="The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.">Eric and Wendy Schmidt Center <span class="sf-description">The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.</span></a></li><li id="header-menu-menu-link-content13d4c1b3-4076-45da-bf73-8a5d2c08222e" class="sf-depth-2 sf-no-children"><a href="/stanley-center-for-psychiatric-research" class="sf-depth-2" title="The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.">Stanley Center for Psychiatric Research <span class="sf-description">The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.</span></a></li></ol></li></ul></li><li id="header-menu-menu-link-content77da995c-f5d1-4f7a-bcf0-9955394a546b" class="sf-depth-1 menuparent"><a href="/education-and-outreach" class="sf-depth-1 menuparent">Education and outreach</a><ul class="sf-multicolumn"><li class="sf-multicolumn-wrapper "><ol><li id="header-menu-menu-link-content7d3d54b0-8276-4d96-8184-c75a39b36485" class="sf-depth-2 sf-no-children"><a 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">Broad Discovery Center <span class="sf-description">Visit our free public educational space that showcases how researchers at the Broad and their colleagues around the world seek to understand and treat human disease. </span></a></li><li id="header-menu-menu-link-content69a14c4f-942a-47cf-ada5-0603f64a74a7" class="sf-depth-2 sf-no-children"><a href="/learning-resources" class="sf-depth-2" title="Access free classroom materials and more for STEM educators, parents, students, tutors, and others.">Learning resources <span class="sf-description">Access free classroom materials and more for STEM educators, parents, students, tutors, and others.</span></a></li><li id="header-menu-menu-link-contentfa54febf-3b0a-4901-8f6d-5b1ca8073ed5" class="sf-depth-2 sf-no-children"><a href="/public-programs" class="sf-depth-2" title="Discover remarkable stories of scientific progress, and explore the intersections of science, medicine, and society."> Public programs <span class="sf-description">Discover 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href="https://giving.broadinstitute.org/" class="menu-link_mobile sf-depth-1 sf-external" target="_blank">Giving</a></li><li id="header-menu-menu-link-content32de5f66-eff6-4cde-9d5b-c25acdaa8947" class="sf-depth-1 mobile-wrapper-links sf-no-children"><a href="https://intranet.broadinstitute.org" class="menu-link_mobile sf-depth-1 sf-external" target="_blank">Intranet</a></li><li id="header-menu-menu-link-contentc13b0045-6a18-4925-8006-dd7744b9f280" class="sf-depth-1 mobile-wrapper-links sf-no-children"><a href="/search" class="menu-link_mobile sf-depth-1">Search</a></li> </ul> </div> </div> </div> </div> </div> </header> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div><div id="block-page-content" class="block block-system block-system-main-block"> <article about="/diabetes" class="node node--type-landing-page node--view-mode-full"> <div class="node__content"> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/disease-areas">Disease Areas</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Diabetes</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Type 2 diabetes (T2D) affects more than 463 million people worldwide and is a leading cause of morbidity and mortality across the globe.</p> </div> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/2022-11/diabetes.png?itok=550cxgjv 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/2022-11/diabetes.png?itok=550cxgjv 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/2022-11/diabetes.png?itok=3h1_67nb 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/2022-11/diabetes.png?itok=mEEinx2H 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/2022-11/diabetes.png?itok=XYZ8JRTX 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/2022-11/diabetes.png?itok=lz02a51R 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"/> <img loading="eager" src="/files/styles/multiple_ct_header_phone/public/2022-11/diabetes.png?itok=lz02a51R" width="499" height="294" alt="An intact pancreatic islet treated with interferon alpha and gamma, and stained for HLA-1 (yellow), proinsulin (magenta), nuclei (cyan)." title="An intact pancreatic islet treated with interferon alpha and gamma, and stained for HLA-1 (yellow), proinsulin (magenta), nuclei (cyan)." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__description"> An intact pancreatic islet treated with interferon alpha and gamma, and stained for HLA-1 (yellow), proinsulin (magenta), nuclei (cyan). </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Diabetes and its complications represent one of the most serious challenges to public health in the 21<sup>st</sup> century. With its concomitant life-threatening complications of cardiovascular disease, renal failure, blindness, and peripheral vascular disease, T2D can undermine the global economy, with a disproportionate burden on underprivileged groups and emerging nations.</p> <p>The T2D epidemic is occurring as a result of deleterious changes in our environment, diet, and lifestyle, which take place against a background of genetic predisposition. Many large-scale, genome-wide investigations have sought to identify the genetic roots of T2D. Broad researchers study genes associated with the disease to uncover their molecular functions, their roles in relevant cell models, and their impacts on both mouse and human physiology. At the Broad, a community of scientists known as the Diabetes Research Group is dedicated to studying diabetes, with five major research aims: genetic discovery, functional validation, physiological characterization, clinical translation, and therapeutic discovery.</p> <p>The overarching goal of these efforts is to determine the genetic underpinnings of this disease and translate that knowledge into clinical and therapeutic interventions. Members of the Diabetes Research Group are dedicated to pursuing this new area of genetics research with the aim of contributing to improved medical care for those with, or at risk of developing, type 2 diabetes.</p> </div> </div> </div> <div class="content-section__right col-2"> <div class="open block block-broad-menu-reference block-broad-menu-blockadmin"> <h2>Diabetes</h2> <ul class="menu"> <li class="menu-item"> <a href="/diabetes" data-drupal-link-system-path="node/8502" class="is-active" aria-current="page">About</a> </li> <li class="menu-item"> <a href="/diabetes/diabetes-team" data-drupal-link-system-path="node/8840">Team</a> </li> </ul> </div> <div class="open block block-broad-menu-reference block-broad-menu-blockadmin"> <h2>Areas of Focus</h2> <ul class="menu"> <li class="menu-item"> <a href="/diabetes/genetic-basis-type-2-diabetes-t2d-and-t2d-related-traits" data-drupal-link-system-path="node/8822">Genetic Basis of Type 2 Diabetes (T2D) and T2D-related Traits</a> </li> <li class="menu-item"> <a href="/diabetes/functional-characterization-t2d-associated-genes-and-pathways" data-drupal-link-system-path="node/8823">Functional Characterization of T2D-associated Genes and Pathways</a> </li> <li class="menu-item"> <a href="/diabetes/translation-genetic-information-clinical-practice" data-drupal-link-system-path="node/8824">Translation of Genetic Information to Clinical Practice</a> </li> <li class="menu-item"> <a href="/diabetes/chemical-biology-diabetes" data-drupal-link-system-path="node/8825">Chemical Biology of Diabetes</a> </li> </ul> </div> <div class="block block-ctools block-entity-viewnode"> <article about="/diabetes" class="node node--type-landing-page node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-video-embed"> <div class="field field--name-field-video-embed field--type-video-embed-field field--label-hidden field__item"><div class="video-embed-field-provider-youtube video-embed-field-responsive-video"><iframe width="854" height="480" frameborder="0" allowfullscreen="allowfullscreen" src="https://www.youtube.com/embed/7tNDMlCyON4?autoplay=0&start=0&rel=0"></iframe> </div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-landing-investigators"> <h2>Investigators</h2> <div class="field field--name-field-landing-investigators field--type-entity-reference field--label-hidden field__items"> <div class="field__item"> <article about="/bios/jose-florez" class="node node--type-biosketch node--view-mode-teaser"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block block-layout-builder block-field-blocknodebiosketchfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-pt-sbs-2-images"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/Florez.jpg?h=8431d930&itok=RK4aiD5r 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/Florez.jpg?h=8431d930&itok=RK4aiD5r 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop/public/bios/photos/Florez.jpg?h=8431d930&itok=92Yxe6_Y 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="609" height="413"/> <source srcset="/files/styles/pt_sbs_2_images_laptop/public/bios/photos/Florez.jpg?h=8431d930&itok=HFAAOjSE 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="594" height="388"/> <source srcset="/files/styles/pt_sbs_2_images_tablet/public/bios/photos/Florez.jpg?h=8431d930&itok=OWrDSXuJ 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="704" height="406"/> <source srcset="/files/styles/pt_sbs_2_images_phone/public/bios/photos/Florez.jpg?h=8431d930&itok=-5I0nbCt 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="288"/> <img loading="eager" src="/files/styles/pt_sbs_2_images_phone/public/bios/photos/Florez.jpg?h=8431d930&itok=-5I0nbCt" width="499" height="288" alt="" typeof="foaf:Image" /> </picture> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block block-layout-builder block-field-blocknodebiosketchtitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/bios/jose-florez" hreflang="und">Jose Florez</a></span> </div> <div class="block block-layout-builder block-field-blocknodebiosketchfield-featured-title"> <div class="clearfix text-formatted field field--name-field-featured-title field--type-text field--label-hidden field__item"><p>Institute Member, Co-director of the Metabolism Program</p> </div> </div> </div> </div> </div> </article> </div> <div class="field__item"> <article about="/bios/jason-flannick" class="node node--type-biosketch node--view-mode-teaser"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block block-layout-builder block-field-blocknodebiosketchfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-pt-sbs-2-images"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/JasonFlannick-bio.png?itok=Vgp1Qm7P 1x" media="all and (min-width: 1921px)" type="image/png" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/JasonFlannick-bio.png?itok=Vgp1Qm7P 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop/public/bios/photos/JasonFlannick-bio.png?itok=J__xsTgA 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="609" height="413"/> <source srcset="/files/styles/pt_sbs_2_images_laptop/public/bios/photos/JasonFlannick-bio.png?itok=OAy3Accp 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="594" height="388"/> <source srcset="/files/styles/pt_sbs_2_images_tablet/public/bios/photos/JasonFlannick-bio.png?itok=-1xziSh1 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="704" height="406"/> <source srcset="/files/styles/pt_sbs_2_images_phone/public/bios/photos/JasonFlannick-bio.png?itok=6T3xVUrD 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="288"/> <img loading="eager" src="/files/styles/pt_sbs_2_images_phone/public/bios/photos/JasonFlannick-bio.png?itok=6T3xVUrD" width="499" height="288" alt="" typeof="foaf:Image" /> </picture> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block block-layout-builder block-field-blocknodebiosketchtitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/bios/jason-flannick" hreflang="und">Jason Flannick</a></span> </div> <div class="block block-layout-builder block-field-blocknodebiosketchfield-featured-title"> <div class="clearfix text-formatted field field--name-field-featured-title field--type-text field--label-hidden field__item"><p>Associate Member</p> </div> </div> </div> </div> </div> </article> </div> <div class="field__item"> <article about="/bios/melina-claussnitzer" class="node node--type-biosketch node--view-mode-teaser"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block block-layout-builder block-field-blocknodebiosketchfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-pt-sbs-2-images"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/melinaClaussnitzer-bio_2_0.png?h=074fffee&itok=ja3peSJX 1x" media="all and (min-width: 1921px)" type="image/png" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/melinaClaussnitzer-bio_2_0.png?h=074fffee&itok=ja3peSJX 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop/public/bios/photos/melinaClaussnitzer-bio_2_0.png?h=074fffee&itok=YLeUSq7- 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="609" height="413"/> <source srcset="/files/styles/pt_sbs_2_images_laptop/public/bios/photos/melinaClaussnitzer-bio_2_0.png?h=074fffee&itok=57QDNq2M 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="594" height="388"/> <source srcset="/files/styles/pt_sbs_2_images_tablet/public/bios/photos/melinaClaussnitzer-bio_2_0.png?h=074fffee&itok=oJwvriMB 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="704" height="406"/> <source srcset="/files/styles/pt_sbs_2_images_phone/public/bios/photos/melinaClaussnitzer-bio_2_0.png?h=074fffee&itok=sYmC_ocb 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="288"/> <img loading="eager" src="/files/styles/pt_sbs_2_images_phone/public/bios/photos/melinaClaussnitzer-bio_2_0.png?h=074fffee&itok=sYmC_ocb" width="499" height="288" alt="Melina Claussnitzer" title="Melina Claussnitzer" typeof="foaf:Image" /> </picture> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block block-layout-builder block-field-blocknodebiosketchtitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/bios/melina-claussnitzer" hreflang="und">Melina Claussnitzer</a></span> </div> <div class="block block-layout-builder block-field-blocknodebiosketchfield-featured-title"> <div class="clearfix text-formatted field field--name-field-featured-title field--type-text field--label-hidden field__item"><p>Institute Member</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="views-element-container block block-views block-views-blockrelated-publications-list-more-link"> <div class="publications-list-wrapper"> <div class="publications-list-wrapper__title"> <h2>Recent publications</h2> <div class="more-link"> <a href="/publications-list/615">Other Diabetes publications</a> </div> </div> <div><div class="view view-related-publications view-id-related_publications view-display-id-list_more_link js-view-dom-id-bc2c34f66c7038ea6c66409cf6dc53976aa828acb84cf85e94a688b541ed6156"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad55926" hreflang="en">Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad11451" hreflang="en">Type 2 diabetes: genetic data sharing to advance complex disease research.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad22636" hreflang="en">The genetic architecture of type 2 diabetes.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad7897" hreflang="en">Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad7997" hreflang="en">Inhibition of DYRK1A Stimulates Human 尾-Cell Proliferation.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad7433" hreflang="en">Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad6332" hreflang="en">Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad6671" hreflang="en">The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad5576" hreflang="en">Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.</a></span></div></div> </div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blockrelated-items-list"> <div class="related-items-list-wrapper"> <h3>Related</h3> <div><div class="view view-related-items view-id-related_items view-display-id-list js-view-dom-id-92d0f79711126456eb6d10e05378282c68080455c0ed3a939222f75c2e75c4d1"> <div class="view-content"> <div class="slick blazy slick--view slick--view--related-items slick--view--related-items--list slick--view--related-items-block-list slick--skin--default slick--optionset--slider-with-tabs-module" data-blazy=""><div id="slick-108248bb8ce" data-slick="{"count":5,"total":5,"lazyLoad":"blazy","swipeToSlide":true,"touchThreshold":100}" class="slick__slider"> <div class="slick__slide slide slide--0"> <article about="/news/gut-microbiome-changes-fuel-increased-risk-type-2-diabetes" class="node node--type-long-story node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodelong-storyfield-preview-image"> <div class="field field--name-field-preview-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="https://www.broadinstitute.org/news/gut-microbiome-changes-fuel-increased-risk-type-2-diabetes"><picture> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/gut_bacteria_NIH_crop_53006111880_2acea642fb_k.png?itok=Jz9aZnrV 1x" media="all and (min-width: 1921px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/gut_bacteria_NIH_crop_53006111880_2acea642fb_k.png?itok=Jz9aZnrV 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/gut_bacteria_NIH_crop_53006111880_2acea642fb_k.png?itok=Jz9aZnrV 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_laptop/public/longstory/gut_bacteria_NIH_crop_53006111880_2acea642fb_k.png?itok=iMFSDvEW 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="610" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_tablet/public/longstory/gut_bacteria_NIH_crop_53006111880_2acea642fb_k.png?itok=wsDIkoXG 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/gut_bacteria_NIH_crop_53006111880_2acea642fb_k.png?itok=_yyLI789 1x" media="all and (max-width: 539px)" type="image/png" width="500" height="400"/> <img loading="eager" src="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/gut_bacteria_NIH_crop_53006111880_2acea642fb_k.png?itok=_yyLI789" width="500" height="400" alt="An illustration of gut bacteria, showing a dense cluster of rod-shaped microbes in various bright colors, including blue, green, orange, and purple. The bacteria are depicted in a stylized, almost three-dimensional manner, highlighting their diverse shapes and structures against a dark background." title="An illustration of gut bacteria, showing a dense cluster of rod-shaped microbes in various bright colors, including blue, green, orange, and purple. The bacteria are depicted in a stylized, almost three-dimensional manner, highlighting their diverse shapes and structures against a dark background." typeof="foaf:Image" /> </picture></a> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block-teaser-date block block-layout-builder block-extra-field-blocknodelong-storyextra-field-news-tag-date"> <a href="/news/gut-microbiome-changes-fuel-increased-risk-type-2-diabetes">News 06.25.2024</a> </div> <div class="block-teaser-title block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/news/gut-microbiome-changes-fuel-increased-risk-type-2-diabetes" hreflang="en">Gut microbiome changes align with increased risk of type 2 diabetes</a></span> </div> <div class="block-teaser-link block block-layout-builder block-extra-field-blocknodelong-storyextra-field-readmore"> <div class="field field--name-extra-field-readmore field--type-extra-field field--label-hidden field__items"> <div class="field__item"><a href="https://www.broadinstitute.org/news/gut-microbiome-changes-fuel-increased-risk-type-2-diabetes" hreflang="en">Read more</a></div> </div> </div> </div> </div> </div> </article> </div> <div class="slick__slide slide slide--1"> <article about="/news/study-reveals-genetic-clusters-may-explain-differences-type-2-diabetes-risk" class="node node--type-long-story node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodelong-storyfield-preview-image"> <div class="field field--name-field-preview-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="https://www.broadinstitute.org/news/study-reveals-genetic-clusters-may-explain-differences-type-2-diabetes-risk"><picture> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/DNA_Tripple_Orange.png?itok=_HSqehKx 1x" media="all and (min-width: 1921px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/DNA_Tripple_Orange.png?itok=_HSqehKx 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/DNA_Tripple_Orange.png?itok=_HSqehKx 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_laptop/public/longstory/DNA_Tripple_Orange.png?itok=qlBnNza9 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="610" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_tablet/public/longstory/DNA_Tripple_Orange.png?itok=PjltioZe 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/DNA_Tripple_Orange.png?itok=zID7dQnU 1x" media="all and (max-width: 539px)" type="image/png" width="500" height="400"/> <img loading="eager" src="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/DNA_Tripple_Orange.png?itok=zID7dQnU" width="500" height="400" alt="Graphic depicting DNA and people" title="Graphic depicting DNA and people" typeof="foaf:Image" /> </picture></a> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block-teaser-date block block-layout-builder block-extra-field-blocknodelong-storyextra-field-news-tag-date"> <a href="/news/study-reveals-genetic-clusters-may-explain-differences-type-2-diabetes-risk">News 03.08.2024</a> </div> <div class="block-teaser-title block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/news/study-reveals-genetic-clusters-may-explain-differences-type-2-diabetes-risk" hreflang="en">Study reveals genetic clusters that may explain differences in type 2 diabetes risk</a></span> </div> <div class="block-teaser-link block block-layout-builder block-extra-field-blocknodelong-storyextra-field-readmore"> <div class="field field--name-extra-field-readmore field--type-extra-field field--label-hidden field__items"> <div class="field__item"><a href="https://www.broadinstitute.org/news/study-reveals-genetic-clusters-may-explain-differences-type-2-diabetes-risk" hreflang="en">Read more</a></div> </div> </div> </div> </div> </div> </article> </div> <div class="slick__slide slide slide--2"> <article about="/news/largest-and-most-diverse-genome-wide-association-study-type-2-diabetes-reveals-new-genetic-0" class="node node--type-long-story node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodelong-storyfield-preview-image"> <div class="field field--name-field-preview-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="https://www.broadinstitute.org/news/largest-and-most-diverse-genome-wide-association-study-type-2-diabetes-reveals-new-genetic-0"><picture> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/0224_Diabetes%20GWAS%20news%20story.jpeg?h=ae0fde30&itok=9hd0cm4m 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/0224_Diabetes%20GWAS%20news%20story.jpeg?h=ae0fde30&itok=9hd0cm4m 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/0224_Diabetes%20GWAS%20news%20story.jpeg?h=ae0fde30&itok=9hd0cm4m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="768" height="400"/> <source 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