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class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/research-areas">Research Areas</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Metabolism</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Metabolism is the integration of all chemical reactions in our body. Metabolic processes control how we use or store energy and nutrients from food, and how we create, modify, or degrade biologically active small molecules. Inherited or acquired defects in metabolism can lead directly to disease — ranging from rare, lethal genetic disorders to major public health problems such as type 2 diabetes and obesity.</p> <p> </p> </div> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/2022-11/metabolism.png?itok=b_UwLtQm 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/2022-11/metabolism.png?itok=b_UwLtQm 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/2022-11/metabolism.png?itok=fOKuuHLl 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/2022-11/metabolism.png?itok=tqcBUdFX 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/2022-11/metabolism.png?itok=668u1Sqv 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/2022-11/metabolism.png?itok=RiWqw_cG 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/2022-11/metabolism.png?itok=RiWqw_cG" alt="Transmission electron microscope image of a mitochondria." title="Transmission electron microscope image of a mitochondria." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Louisa Howard </div> <div class="media-caption__description"> Transmission electron microscope image of a mitochondria. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The goal of the Broad Metabolism Program (BMP) is to pioneer new methods to systematically investigate metabolism and exploit the resulting discoveries to decipher the metabolic basis of human disease, leading to better treatments or interventions.</p> <p>BMP is a highly collaborative network with close connections to the Broad’s <a href="/node/8539" title="Metabolomics Platform website">Metabolomics Platform</a>, as well as the <a href="/node/8517" title="Genomics Platform website">Genomics Platform</a>, the <a href="/node/8530" title="Proteomics Platform website">Proteomics Platform</a>, and the <a href="/node/485396" title="Center for the Development of Therapeutics website">Center for the Development of Therapeutics</a>. Many BMP investigators are based at relevant clinical units in affiliated hospitals, and also participate in other institute efforts such as the <a href="https://www.broadinstitute.org/node/8510">Cardiovascular Disease Initiative</a>, the <a href="https://www.broadinstitute.org/node/412561">Kidney Disease Initiative</a>, and the <a href="https://www.broadinstitute.org/node/1099156">Novo Nordisk Foundation Center for Genomic Mechanisms of Disease</a>.</p> <p> </p> </div> </div> </div> <div class="content-section__right col-2"> <div class="open block block-broad-menu-reference block-broad-menu-blockadmin"> <h2>Metabolism</h2> <ul class="menu"> <li class="menu-item"> <a href="/metabolism" data-drupal-link-system-path="node/8516" class="is-active" aria-current="page">About</a> </li> <li class="menu-item"> <a href="/scientific-community/science/programs/metabolic-disease-program/team" data-drupal-link-system-path="node/231">Team</a> </li> </ul> </div> <div class="open block block-broad-menu-reference block-broad-menu-blockadmin"> <h2>Areas of Focus</h2> <ul class="menu"> <li class="menu-item"> <a href="/diabetes" title="Diabetes Disease Area" data-drupal-link-system-path="node/8502">Diabetes</a> </li> <li class="menu-item"> <a href="/obesity" title="Obesity Disease Area" data-drupal-link-system-path="node/8504">Obesity</a> </li> <li class="menu-item"> <a href="/rare-diseases/mitochondrial-disease" title="Mitochondrial Disease Area" data-drupal-link-system-path="node/8720">Mitochondrial Disease</a> </li> <li class="menu-item"> <a href="/faa" title="Friedreich’s Ataxia Accelerator">Friedreich’s Ataxia Accelerator</a> </li> </ul> </div> <div class="block block-ctools block-entity-viewnode"> <article about="/metabolism" class="node node--type-landing-page node--view-mode-sidebar"> <div class="node__content"> </div> </article> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="views-element-container block block-views block-views-blockrelated-publications-list-more-link"> <div class="publications-list-wrapper"> <div class="publications-list-wrapper__title"> <h2>Recent publications</h2> <div class="more-link"> <a href="/publications-list/596">Other Metabolism Program publications</a> </div> </div> <div><div class="view view-related-publications view-id-related_publications view-display-id-list_more_link js-view-dom-id-21ef9bb9e3a9789ce6d49d80097feeaf5b3a1184cf7c3e50daa6f7ea8140f295"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1339051" hreflang="en">Effect of Sickle Cell Trait and Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad19661" hreflang="en">Mitochondrial dysfunction remodels one-carbon metabolism in human cells.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad7688" hreflang="en">Correlating chemical sensitivity and basal gene expression reveals mechanism of action.</a></span></div></div> </div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blockrelated-items-list"> <div class="related-items-list-wrapper"> <h3>Related</h3> <div><div class="view--blazy view view-related-items view-id-related_items view-display-id-list js-view-dom-id-7272384783504d17f78d24f695a1d97de634a87e08ebba6917781dd98f3154b0"> <div class="view-content"> <div class="slick blazy slick--view slick--view--related-items slick--view--related-items--list slick--view--related-items-block-list slick--skin--default slick--optionset--slider-with-tabs-module" data-blazy=""><div id="slick-108248bb8ce" data-slick="{"count":5,"total":5,"lazyLoad":"blazy","swipeToSlide":true,"touchThreshold":100}" class="slick__slider"> <div class="slick__slide slide slide--0"> <article about="/news/lipocyte-profiler-metabolic-biology-tool" class="node node--type-long-story node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodelong-storyfield-preview-image"> <div class="field field--name-field-preview-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="https://www.broadinstitute.org/news/lipocyte-profiler-metabolic-biology-tool"><picture> <source 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