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A critical epigenetic mark could be miswritten. A key circuit might be over- or under-active. We use a diverse set of tools — including genetic perturbations and genome- and proteome-wide measurements — to decipher the functions of coding and non-coding regions of the genome and study cellular circuitry, with a strong emphasis on the analysis of single cells." /> <link rel="shortlink" href="https://www.broadinstitute.org/node/8796" /> <link rel="canonical" href="https://www.broadinstitute.org/genomeregulation-cellcircuitry-epigenomics" /> <link rel="image_src" href="https://www.broadinstitute.org/files/2022-06/Screenshot_8%20%281%29.png" /> <meta property="og:site_name" content="@broadinstitute" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.broadinstitute.org/genomeregulation-cellcircuitry-epigenomics" /> <meta property="og:title" content="Genome regulation, cellular circuitry and epigenomics" /> <meta property="og:description" content="In disease, a key gene regulator could be missing or defective. A critical epigenetic mark could be miswritten. A key circuit might be over- or under-active. We use a diverse set of tools — including genetic perturbations and genome- and proteome-wide measurements — to decipher the functions of coding and non-coding regions of the genome and study cellular circuitry, with a strong emphasis on the analysis of single cells." /> <meta property="og:image" content="https://www.broadinstitute.org/files/2022-06/Screenshot_8%20%281%29.png" /> <meta property="og:image:url" content="https://www.broadinstitute.org/files/2022-06/Screenshot_8%20%281%29.png" /> <meta property="og:image:secure_url" content="https://www.broadinstitute.org/files/2022-06/Screenshot_8%20%281%29.png" /> <meta property="og:updated_time" content="2022-12-28T19:46:26-05:00" /> <meta property="article:published_time" content="2016-06-27T11:07:15-04:00" /> <meta property="article:modified_time" content="2016-06-27T11:07:15-04:00" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:title" content="Genome regulation, cellular circuitry and epigenomics" /> <meta name="twitter:description" content="In disease, a key gene regulator could be missing or defective. A critical epigenetic mark could be miswritten. A key circuit might be over- or under-active. We use a diverse set of tools — including genetic perturbations and genome- and proteome-wide measurements — to decipher the functions of coding and non-coding regions of the genome and study cellular circuitry, with a strong emphasis on the analysis of single cells." /> <meta name="twitter:site" content="@broadinstitute" /> <meta name="twitter:creator" content="@broadinstitute" /> <meta name="twitter:image" content="https://www.broadinstitute.org/files/2022-06/Screenshot_8%20%281%29.png" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/themes/custom/broad/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Genome regulation, cellular circuitry and epigenomics | Broad Institute</title> <link rel="stylesheet" media="all" 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class="node__content"> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/research-areas">Research Areas</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1> Genome regulation, cellular circuitry and epigenomics</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>We build comprehensive models of cell and tissue circuits in order to understand how human disease arises from variations in these processes. We monitor the activities of many molecular elements that define and regulate the cell, including DNA, RNA, transcription factors, chromatin regulators, histone modifications, and signaling proteins.</p> </div> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/2022-06/Screenshot_8%20%281%29.png?itok=ydJ9V0Ki 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/2022-06/Screenshot_8%20%281%29.png?itok=ydJ9V0Ki 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/2022-06/Screenshot_8%20%281%29.png?itok=P2nM7Jok 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/2022-06/Screenshot_8%20%281%29.png?itok=e4YWRkK6 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/2022-06/Screenshot_8%20%281%29.png?itok=rENnugeW 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/2022-06/Screenshot_8%20%281%29.png?itok=AffjR2qX 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"/> <img loading="eager" src="/files/styles/multiple_ct_header_phone/public/2022-06/Screenshot_8%20%281%29.png?itok=AffjR2qX" width="499" height="294" alt="Screenshot_8" typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Screenshot_8 </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>In disease, a key gene regulator could be missing or defective. A critical epigenetic mark could be miswritten. A key circuit might be over- or under-active. We use a diverse set of tools — including genetic perturbations and genome- and proteome-wide measurements — to decipher the functions of coding and non-coding regions of the genome and study cellular circuitry, with a strong emphasis on the analysis of single cells.</p> </div> </div> </div> <div class="content-section__right col-2"> <div class="open block block-broad-menu-reference block-broad-menu-blockadmin"> <h2>Genome Regulation, Cellular Circuitry and Epigenomics</h2> <ul class="menu"> <li class="menu-item"> <a href="/genomeregulation-cellcircuitry-epigenomics" data-drupal-link-system-path="node/8796" class="is-active" aria-current="page">About</a> </li> <li class="menu-item"> <a href="/cell-circuits-and-complex-tissues" data-drupal-link-system-path="node/8832">Cell Circuits and Complex Tissues</a> </li> <li class="menu-item"> <a href="/epigenomics" data-drupal-link-system-path="node/8831">Epigenomics</a> </li> <li class="menu-item"> <a href="/gene-regulation-observatory-gro" data-drupal-link-system-path="node/768556">Gene Regulation Observatory (GRO)</a> </li> </ul> </div> <div class="block block-ctools block-entity-viewnode"> <article about="/genomeregulation-cellcircuitry-epigenomics" class="node node--type-landing-page node--view-mode-sidebar"> <div class="node__content"> </div> </article> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-landing-investigators"> <h2>Investigators</h2> <div class="field field--name-field-landing-investigators field--type-entity-reference field--label-hidden field__items"> <div class="field__item"> <article about="/bios/bradley-e-bernstein" class="node node--type-biosketch node--view-mode-teaser"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block block-layout-builder block-field-blocknodebiosketchfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-pt-sbs-2-images"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/Brad%20Bernstein.jpg?h=3449d55f&itok=J8C88Har 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/Brad%20Bernstein.jpg?h=3449d55f&itok=J8C88Har 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop/public/bios/photos/Brad%20Bernstein.jpg?h=3449d55f&itok=Ufm96BWW 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="609" height="413"/> <source srcset="/files/styles/pt_sbs_2_images_laptop/public/bios/photos/Brad%20Bernstein.jpg?h=3449d55f&itok=f1g3N-Wi 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="594" height="388"/> <source srcset="/files/styles/pt_sbs_2_images_tablet/public/bios/photos/Brad%20Bernstein.jpg?h=3449d55f&itok=jPrNi8CI 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="704" height="406"/> <source srcset="/files/styles/pt_sbs_2_images_phone/public/bios/photos/Brad%20Bernstein.jpg?h=3449d55f&itok=VzALRIYs 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="288"/> <img loading="eager" src="/files/styles/pt_sbs_2_images_phone/public/bios/photos/Brad%20Bernstein.jpg?h=3449d55f&itok=VzALRIYs" width="499" height="288" alt="" typeof="foaf:Image" /> </picture> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block block-layout-builder block-field-blocknodebiosketchtitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/bios/bradley-e-bernstein" hreflang="und">Bradley E. Bernstein</a></span> </div> <div class="block block-layout-builder block-field-blocknodebiosketchfield-featured-title"> <div class="clearfix text-formatted field field--name-field-featured-title field--type-text field--label-hidden field__item"><p>Institute Member, Director of the Gene Regulation Observatory, and Director of the Epigenomics Program</p> </div> </div> </div> </div> </div> </article> </div> <div class="field__item"> <article about="/bios/nir-hacohen" class="node node--type-biosketch node--view-mode-teaser"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block block-layout-builder block-field-blocknodebiosketchfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-pt-sbs-2-images"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/Nir%20Hacohen_0.jpg?h=288cf1da&itok=aa0lYots 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/Nir%20Hacohen_0.jpg?h=288cf1da&itok=aa0lYots 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop/public/bios/photos/Nir%20Hacohen_0.jpg?h=288cf1da&itok=6bHvusd6 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="609" height="413"/> <source srcset="/files/styles/pt_sbs_2_images_laptop/public/bios/photos/Nir%20Hacohen_0.jpg?h=288cf1da&itok=0XlzaNwg 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="594" height="388"/> <source srcset="/files/styles/pt_sbs_2_images_tablet/public/bios/photos/Nir%20Hacohen_0.jpg?h=288cf1da&itok=fSovbV1h 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="704" height="406"/> <source srcset="/files/styles/pt_sbs_2_images_phone/public/bios/photos/Nir%20Hacohen_0.jpg?h=288cf1da&itok=8nIPYWzR 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="288"/> <img loading="eager" src="/files/styles/pt_sbs_2_images_phone/public/bios/photos/Nir%20Hacohen_0.jpg?h=288cf1da&itok=8nIPYWzR" width="499" height="288" alt="" typeof="foaf:Image" /> </picture> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block block-layout-builder block-field-blocknodebiosketchtitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/bios/nir-hacohen" hreflang="und">Nir Hacohen</a></span> </div> <div class="block block-layout-builder block-field-blocknodebiosketchfield-featured-title"> <div class="clearfix text-formatted field field--name-field-featured-title field--type-text field--label-hidden field__item"><p>Core Institute Member, Director of the Cell Circuits Program</p> </div> </div> </div> </div> </div> </article> </div> <div class="field__item"> <article about="/bios/cigall-kadoch" class="node node--type-biosketch node--view-mode-teaser"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block block-layout-builder block-field-blocknodebiosketchfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-pt-sbs-2-images"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/KAdoch.jpg?h=8431d930&itok=wQ3rRN5Q 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/KAdoch.jpg?h=8431d930&itok=wQ3rRN5Q 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop/public/bios/photos/KAdoch.jpg?h=8431d930&itok=vu4xGWsg 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="609" height="413"/> <source srcset="/files/styles/pt_sbs_2_images_laptop/public/bios/photos/KAdoch.jpg?h=8431d930&itok=FZGG0Sy- 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="594" height="388"/> <source srcset="/files/styles/pt_sbs_2_images_tablet/public/bios/photos/KAdoch.jpg?h=8431d930&itok=_MJ7gVBQ 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="704" height="406"/> <source srcset="/files/styles/pt_sbs_2_images_phone/public/bios/photos/KAdoch.jpg?h=8431d930&itok=hbdQUZ-9 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="288"/> <img loading="eager" src="/files/styles/pt_sbs_2_images_phone/public/bios/photos/KAdoch.jpg?h=8431d930&itok=hbdQUZ-9" width="499" height="288" alt="" typeof="foaf:Image" /> </picture> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block block-layout-builder block-field-blocknodebiosketchtitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/bios/cigall-kadoch" hreflang="und">Cigall Kadoch</a></span> </div> <div class="block block-layout-builder block-field-blocknodebiosketchfield-featured-title"> <div class="clearfix text-formatted field field--name-field-featured-title field--type-text field--label-hidden field__item"><p>Institute Member</p> </div> </div> </div> </div> </div> </article> </div> <div class="field__item"> <article about="/bios/jason-d-buenrostro" class="node node--type-biosketch node--view-mode-teaser"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block block-layout-builder block-field-blocknodebiosketchfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-pt-sbs-2-images"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/bio-JasonBuenrostro.png?h=d3c94d2b&itok=mZUecMLH 1x" media="all and (min-width: 1921px)" type="image/png" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop_xl/public/bios/photos/bio-JasonBuenrostro.png?h=d3c94d2b&itok=mZUecMLH 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="616" height="419"/> <source srcset="/files/styles/pt_sbs_2_images_desktop/public/bios/photos/bio-JasonBuenrostro.png?h=d3c94d2b&itok=w3vWPrg1 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="609" height="413"/> <source srcset="/files/styles/pt_sbs_2_images_laptop/public/bios/photos/bio-JasonBuenrostro.png?h=d3c94d2b&itok=cetF2K60 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="594" height="388"/> <source srcset="/files/styles/pt_sbs_2_images_tablet/public/bios/photos/bio-JasonBuenrostro.png?h=d3c94d2b&itok=prl9KDmF 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="704" height="406"/> <source srcset="/files/styles/pt_sbs_2_images_phone/public/bios/photos/bio-JasonBuenrostro.png?h=d3c94d2b&itok=DuCvwx7M 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="288"/> <img loading="eager" src="/files/styles/pt_sbs_2_images_phone/public/bios/photos/bio-JasonBuenrostro.png?h=d3c94d2b&itok=DuCvwx7M" width="499" height="288" alt="Jason D. Buenrostro" title="Jason D. Buenrostro" typeof="foaf:Image" /> </picture> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block block-layout-builder block-field-blocknodebiosketchtitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/bios/jason-d-buenrostro" hreflang="und">Jason D. Buenrostro</a></span> </div> <div class="block block-layout-builder block-field-blocknodebiosketchfield-featured-title"> <div class="clearfix text-formatted field field--name-field-featured-title field--type-text field--label-hidden field__item"><p>Institute Member</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="views-element-container block block-views block-views-blockrelated-publications-list-more-link"> <div class="publications-list-wrapper"> <div class="publications-list-wrapper__title"> <h2>Recent publications</h2> <div class="more-link"> <a href="/publications-list/591">Other Genome regulation, cell circuitry, and epigenomics publications</a> </div> </div> <div><div class="view view-related-publications view-id-related_publications view-display-id-list_more_link js-view-dom-id-f5030f340a1384e3fbccac7ac1cf6295c55c900b2adb80eb295c421d5d0ee662"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad739611" hreflang="en">Parallel Single-Cell RNA-Seq and Genetic Recording Reveals Lineage Decisions in Developing Embryoid Bodies.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad739606" hreflang="en">Perspectives on ENCODE.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad739616" hreflang="en">Expanded encyclopaedias of DNA elements in the human and mouse genomes.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad625976" hreflang="en">Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad613191" hreflang="en">Resolving medulloblastoma cellular architecture by single-cell genomics.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad739601" hreflang="en">Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad10271" hreflang="en">Single-molecule decoding of combinatorially modified nucleosomes.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad7858" hreflang="en">An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad7708" hreflang="en">A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad7719" hreflang="en">Insulator dysfunction and oncogene activation in IDH mutant gliomas.</a></span></div></div> </div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blockrelated-items-list"> <div class="related-items-list-wrapper"> <h3>Related</h3> <div><div class="view view-related-items view-id-related_items view-display-id-list js-view-dom-id-34da4ba96f50191166eda753897dcde660abe4b7cf2affb448434cb39ab80c44"> <div class="view-content"> <div class="slick blazy slick--view slick--view--related-items slick--view--related-items--list slick--view--related-items-block-list slick--skin--default slick--optionset--slider-with-tabs-module" data-blazy=""><div id="slick-108248bb8ce" data-slick="{"count":5,"total":5,"lazyLoad":"blazy","swipeToSlide":true,"touchThreshold":100}" class="slick__slider"> <div class="slick__slide slide slide--0"> <article about="/news/gene-expression-signatures-indicate-loss-function-master-regulators-genome" class="node node--type-long-story node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodelong-storyfield-preview-image"> <div class="field field--name-field-preview-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="https://www.broadinstitute.org/news/gene-expression-signatures-indicate-loss-function-master-regulators-genome"><picture> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/EggCells_DarkBlue.png?itok=V2tAlczq 1x" media="all and (min-width: 1921px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/EggCells_DarkBlue.png?itok=V2tAlczq 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/EggCells_DarkBlue.png?itok=V2tAlczq 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_laptop/public/longstory/EggCells_DarkBlue.png?itok=dFruPEOY 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="610" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_tablet/public/longstory/EggCells_DarkBlue.png?itok=zaOXpwp1 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/EggCells_DarkBlue.png?itok=1Cr7nXGW 1x" media="all and (max-width: 539px)" type="image/png" width="500" height="400"/> <img loading="eager" src="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/EggCells_DarkBlue.png?itok=1Cr7nXGW" width="500" height="400" alt="Illustration of cells on a background of DNA" title="Illustration of cells on a background of DNA" typeof="foaf:Image" /> </picture></a> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block-teaser-date block block-layout-builder block-extra-field-blocknodelong-storyextra-field-news-tag-date"> <a href="/news/gene-expression-signatures-indicate-loss-function-master-regulators-genome">News 04.07.2023</a> </div> <div class="block-teaser-title block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/news/gene-expression-signatures-indicate-loss-function-master-regulators-genome" hreflang="en">Gene expression signatures indicate loss of function by master regulators of the genome</a></span> </div> <div class="block-teaser-link block block-layout-builder block-extra-field-blocknodelong-storyextra-field-readmore"> <div class="field field--name-extra-field-readmore field--type-extra-field field--label-hidden field__items"> <div class="field__item"><a href="https://www.broadinstitute.org/news/gene-expression-signatures-indicate-loss-function-master-regulators-genome" hreflang="en">Read more</a></div> </div> </div> </div> </div> </div> </article> </div> <div class="slick__slide slide slide--1"> <article about="/news/new-dna-sequencing-technique-preserves-cells%E2%80%99-locations-within-tissues" class="node node--type-news node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="https://www.broadinstitute.org/news/new-dna-sequencing-technique-preserves-cells%E2%80%99-locations-within-tissues"><picture> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/news/images/2021/fig2b_for_web.png?h=d3e04ee7&itok=0ULJAjlr 1x" media="all and (min-width: 1921px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/news/images/2021/fig2b_for_web.png?h=d3e04ee7&itok=0ULJAjlr 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/news/images/2021/fig2b_for_web.png?h=d3e04ee7&itok=0ULJAjlr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_laptop/public/news/images/2021/fig2b_for_web.png?h=d3e04ee7&itok=7UNGZoRW 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="610" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_tablet/public/news/images/2021/fig2b_for_web.png?h=d3e04ee7&itok=rCz7I-Gv 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/news/images/2021/fig2b_for_web.png?h=d3e04ee7&itok=IK_BXUE9 1x" media="all and (max-width: 539px)" type="image/png" width="500" height="400"/> <img loading="eager" src="/files/styles/multiple_ct_teaser_related_items_phone/public/news/images/2021/fig2b_for_web.png?h=d3e04ee7&itok=IK_BXUE9" width="500" height="400" alt="An image of how slide-DNA-seq "sees" cells' organization within a tumor." title="An image of how slide-DNA-seq "sees" cells' organization within a tumor." typeof="foaf:Image" /> </picture></a> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block-teaser-date block block-layout-builder 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1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/news/images/2021/ProteinImmunotherapyGraphic.png?h=b44d6655&itok=-iu8iMbQ 1x" media="all and (max-width: 539px)" type="image/png" width="500" height="400"/> <img loading="eager" src="/files/styles/multiple_ct_teaser_related_items_phone/public/news/images/2021/ProteinImmunotherapyGraphic.png?h=b44d6655&itok=-iu8iMbQ" width="500" height="400" alt="Zayna Sheikh, Broad Communications" typeof="foaf:Image" /> </picture></a> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block-teaser-date block block-layout-builder block-extra-field-blocknodenewsextra-field-news-tag-date"> <a href="/news/tumors-hide-immune-system-help-protein">News 05.05.2021</a> </div> <div class="block-teaser-title block block-layout-builder block-field-blocknodenewstitle"> <span 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type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/blog/images/2021/Torlai_main_v2_0.png?itok=xIawaDkb 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_laptop/public/blog/images/2021/Torlai_main_v2_0.png?itok=Ul_G7Z73 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="610" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_tablet/public/blog/images/2021/Torlai_main_v2_0.png?itok=gpA7LeSn 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/blog/images/2021/Torlai_main_v2_0.png?itok=zSmLoIt8 1x" media="all and (max-width: 539px)" type="image/png" width="500" height="400"/> <img loading="eager" 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media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/news/images/2021/glimoa%20cells%20nci-vol-11261-150%20cropped.jpg?h=d3e04ee7&itok=SjVb-XE1 1x" media="all and (max-width: 539px)" type="image/jpeg" width="500" height="400"/> <img loading="eager" src="/files/styles/multiple_ct_teaser_related_items_phone/public/news/images/2021/glimoa%20cells%20nci-vol-11261-150%20cropped.jpg?h=d3e04ee7&itok=SjVb-XE1" width="500" height="400" alt="Glioma cells. 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