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As mammalian oocyte development begins in fetal" /> <meta property="article:author" content="https://independent.academia.edu/RebeccaVanders" /> <meta name="description" content="The theory of fetal origins of adult disease was first proposed in 1989 and in the decades since, a wide range of other diseases from obesity to asthma have been found to originate in early development. As mammalian oocyte development begins in fetal" /> <meta name="robots" content="noindex" /> <title>Maternal Smoke Exposure Impairs the Long Term Fertility of Female Offspring in a Murine Model | Rebecca Vanders - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/34431203/Maternal_Smoke_Exposure_Impairs_the_Long_Term_Fertility_of_Female_Offspring_in_a_Murine_Model" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '1bbbda12a33dda6b7b03832db85b3e64a22beabd'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732756493000); window.Aedu.timeDifference = new Date().getTime() - 1732756493000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"The theory of fetal origins of adult disease was first proposed in 1989 and in the decades since, a wide range of other diseases from obesity to asthma have been found to originate in early development. As mammalian oocyte development begins in fetal life it has been suggested that environmental and lifestyle factors of the mother could directly impact the fertility of subsequent generations. Cigarette smoke is a known ovotoxicant in active smokers, yet disturbingly 13% of Australian and 12% of US women continue to smoke throughout pregnancy. The focus of our investigation was to characterize the adverse effects of smoking on ovary and oocyte quality in female offspring exposed in utero. Pregnant mice were nasally exposed to cigarette smoke for 12 wk throughout pregnancy/lactation and ovary and oocyte quality of the F1 (maternal smoke exposed) generation was examined. Neonatal ovaries displayed abnormal somatic cell proliferation and increased apoptosis leading to a reduction in fol...","author":[{"@context":"https://schema.org","@type":"Person","name":"Rebecca Vanders"}],"contributor":[],"dateCreated":"2017-08-31","dateModified":"2017-08-31","datePublished":"2016-01-13","headline":"Maternal Smoke Exposure Impairs the Long Term Fertility of Female Offspring in a Murine Model","inLanguage":"en","keywords":["Fertility","Oxidative Stress","Biological Sciences","Pregnancy","Mice","Female","Animals","Smoke","Ovarian Follicle","Ovary","Oocytes","Biology Reproduction","Maternal Exposure"],"locationCreated":null,"publication":"Biology of reproduction","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/34431203/Maternal_Smoke_Exposure_Impairs_the_Long_Term_Fertility_of_Female_Offspring_in_a_Murine_Model","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link 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As mammalian oocyte development begins in fetal life it has been suggested that environmental and lifestyle factors of the mother could directly impact the fertility of subsequent generations. Cigarette smoke is a known ovotoxicant in active smokers, yet disturbingly 13% of Australian and 12% of US women continue to smoke throughout pregnancy. The focus of our investigation was to characterize the adverse effects of smoking on ovary and oocyte quality in female offspring exposed in utero. Pregnant mice were nasally exposed to cigarette smoke for 12 wk throughout pregnancy/lactation and ovary and oocyte quality of the F1 (maternal smoke exposed) generation was examined. Neonatal ovaries displayed abnormal somatic cell proliferation and increased apoptosis leading to a reduction in fol...","publication_date":"2016,1,13","publication_name":"Biology of reproduction"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"low","language":"en","title":"Maternal Smoke Exposure Impairs the Long Term Fertility of Female Offspring in a Murine Model","broadcastable":false,"draft":null,"has_indexable_attachment":false,"indexable":true}}["work"]; window.loswp.workCoauthors = [67791335]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "grid"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="loswp-grid--container"><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-landing_url="https://www.academia.edu/34431203/Maternal_Smoke_Exposure_Impairs_the_Long_Term_Fertility_of_Female_Offspring_in_a_Murine_Model" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="above-fold js-swp-splash-above-fold"><div class="work-card--container js-swp-control-work-card" data-entity-id="34431203"><div class="work-cover--wrapper"><div class="work-cover--container"><div class="work-cover--no-attachment-container js-swp-splash-paper-cover"><div class="work-cover--file-icon-wrapper"><img alt="paper cover icon" src="//a.academia-assets.com/images/single_work_splash/adobe.icon.svg" /></div><div class="work-cover--title js-swp-splash-paper-cover-page-title">Maternal Smoke Exposure Impairs the Long Term Fertility of Female Offspring in a Murine Model</div><br /><div style="margin-top: 170px"><button class="work-cover--request-pdf-button js-request-pdf-button"><svg style="width: 14px; margin-right: 8px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="envelope" class="svg-inline--fa fa-envelope fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M502.3 190.8c3.9-3.1 9.7-.2 9.7 4.7V400c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V195.6c0-5 5.7-7.8 9.7-4.7 22.4 17.4 52.1 39.5 154.1 113.6 21.1 15.4 56.7 47.8 92.2 47.6 35.7.3 72-32.8 92.3-47.6 102-74.1 131.6-96.3 154-113.7zM256 320c23.2.4 56.6-29.2 73.4-41.4 132.7-96.3 142.8-104.7 173.4-128.7 5.8-4.5 9.2-11.5 9.2-18.9v-19c0-26.5-21.5-48-48-48H48C21.5 64 0 85.5 0 112v19c0 7.4 3.4 14.3 9.2 18.9 30.6 23.9 40.7 32.4 173.4 128.7 16.8 12.2 50.2 41.8 73.4 41.4z"></path></svg>Request PDF</button></div></div></div></div><div class="work-card--content"><h1 class="work-card--title">Maternal Smoke Exposure Impairs the Long Term Fertility of Female Offspring in a Murine Model</h1><div class="work-card--pub-info">Biology of reproduction, 2016</div><div class="work-card--authors-container js-work-toolbar-work-owner"><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><a href="https://independent.academia.edu/RebeccaVanders"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></a></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><a class="u-linkUnstyled u-fw500 u-textTruncate ds2-5-body-sm ds2-5-body-link" href="https://independent.academia.edu/RebeccaVanders" swp="tc-au-34431203">Rebecca Vanders</a></div></div><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><div class="u-fontStyleItalic u-textTruncate">Andrew Jarnicki</div></div></div><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><div class="u-fontStyleItalic u-textTruncate">E. McLaughlin</div></div></div><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><div class="u-fontStyleItalic u-textTruncate">Emma Beckett</div></div></div></div><div class="work-card--no-attachment-details"><div style="font-weight: 700; font-size: 14px;">Abstract</div><div class="work-card--abstract js-swp-splash-abstract">The theory of fetal origins of adult disease was first proposed in 1989 and in the decades since, a wide range of other diseases from obesity to asthma have been found to originate in early development. As mammalian oocyte development begins in fetal life it has been suggested that environmental and lifestyle factors of the mother could directly impact the fertility of subsequent generations. Cigarette smoke is a known ovotoxicant in active smokers, yet disturbingly 13% of Australian and 12% of US women continue to smoke throughout pregnancy. The focus of our investigation was to characterize the adverse effects of smoking on ovary and oocyte quality in female offspring exposed in utero. Pregnant mice were nasally exposed to cigarette smoke for 12 wk throughout pregnancy/lactation and ovary and oocyte quality of the F1 (maternal smoke exposed) generation was examined. Neonatal ovaries displayed abnormal somatic cell proliferation and increased apoptosis leading to a reduction in fol...</div></div><div class="request-upload--container"><p class="request-upload--title">Rebecca Vanders hasn't uploaded this paper.</p><div class="request-upload--info-text"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="info-circle" class="request-upload--info-icon svg-inline--fa fa-info-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z"></path></svg><p class="no-margin hide-on-small-mobile">Let Rebecca know you want this paper to be uploaded.</p><p class="no-margin hide-above-small-mobile">Ask for this paper to be uploaded.</p></div><button class="work-cover--request-pdf-button small js-request-pdf-button hide-on-desktop"><svg style="width: 14px; 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