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Increased levels in dementia of the Alzheimer type</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Memory impairment is a process associated with alterations in neuronal plasticity, synapses formation, and stabilization. As the neural cell adhesion molecule (NCAM) plays a key role in synaptic bond stabilization, we analyzed the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14468274" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Memory impairment is a process associated with alterations in neuronal plasticity, synapses formation, and stabilization. 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type="text/json">{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12071" href="https://www.academia.edu/Documents/in/Immunohistochemistry">Immunohistochemistry</a>, <script data-card-contents-for-ri="12071" type="text/json">{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="60971" href="https://www.academia.edu/Documents/in/Cerebrospinal_Fluid">Cerebrospinal Fluid</a><script data-card-contents-for-ri="60971" type="text/json">{"id":60971,"name":"Cerebrospinal Fluid","url":"https://www.academia.edu/Documents/in/Cerebrospinal_Fluid?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: 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class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26468149/Intermittent_fasting_and_caloric_restriction_ameliorate_age_related_behavioral_deficits_in_the_triple_transgenic_mouse_model_of_Alzheimers_disease">Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26468149" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a 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patel","profile_url":"https://independent.academia.edu/maulikpatel22?f_ri=2214","photo":"https://0.academia-photos.com/13445166/145154761/134684789/s65_maulik.patel.png"}</script></span></span></li><li class="js-paper-rank-work_7512489 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7512489"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7512489, container: ".js-paper-rank-work_7512489", }); });</script></li><li class="js-percentile-work_7512489 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 7512489; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = 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style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="7512489"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">37</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="140" href="https://www.academia.edu/Documents/in/Pharmacology">Pharmacology</a>, <script data-card-contents-for-ri="140" type="text/json">{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2007" href="https://www.academia.edu/Documents/in/Electrophysiology">Electrophysiology</a>, <script data-card-contents-for-ri="2007" type="text/json">{"id":2007,"name":"Electrophysiology","url":"https://www.academia.edu/Documents/in/Electrophysiology?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2214" href="https://www.academia.edu/Documents/in/Neurobiology_Of_Disease">Neurobiology Of Disease</a><script data-card-contents-for-ri="2214" type="text/json">{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7512489]'), work: {"id":7512489,"title":"Behavioral And Electrophysiological Effects Of Ethanol On Crayfish","created_at":"2014-06-30T16:15:44.455-07:00","url":"https://www.academia.edu/7512489/Behavioral_And_Electrophysiological_Effects_Of_Ethanol_On_Crayfish?f_ri=2214","dom_id":"work_7512489","summary":null,"downloadable_attachments":[{"id":48441722,"asset_id":7512489,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":13445166,"first_name":"maulik","last_name":"patel","domain_name":"independent","page_name":"maulikpatel22","display_name":"maulik patel","profile_url":"https://independent.academia.edu/maulikpatel22?f_ri=2214","photo":"https://0.academia-photos.com/13445166/145154761/134684789/s65_maulik.patel.png"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=2214","nofollow":false},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=2214","nofollow":false},{"id":2007,"name":"Electrophysiology","url":"https://www.academia.edu/Documents/in/Electrophysiology?f_ri=2214","nofollow":false},{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false},{"id":2749,"name":"Animal Behavior","url":"https://www.academia.edu/Documents/in/Animal_Behavior?f_ri=2214"},{"id":4307,"name":"Behavior","url":"https://www.academia.edu/Documents/in/Behavior?f_ri=2214"},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=2214"},{"id":14277,"name":"Brain and Cognitive Development","url":"https://www.academia.edu/Documents/in/Brain_and_Cognitive_Development?f_ri=2214"},{"id":25804,"name":"Neurobiology","url":"https://www.academia.edu/Documents/in/Neurobiology?f_ri=2214"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=2214"},{"id":61516,"name":"Evoked Potentials","url":"https://www.academia.edu/Documents/in/Evoked_Potentials?f_ri=2214"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=2214"},{"id":84291,"name":"Change detection","url":"https://www.academia.edu/Documents/in/Change_detection?f_ri=2214"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=2214"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=2214"},{"id":103192,"name":"Motor Coordination","url":"https://www.academia.edu/Documents/in/Motor_Coordination?f_ri=2214"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=2214"},{"id":119665,"name":"Reaction Time","url":"https://www.academia.edu/Documents/in/Reaction_Time?f_ri=2214"},{"id":121707,"name":"Open Field","url":"https://www.academia.edu/Documents/in/Open_Field?f_ri=2214"},{"id":154341,"name":"Pitch Perception","url":"https://www.academia.edu/Documents/in/Pitch_Perception?f_ri=2214"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=2214"},{"id":209780,"name":"Dystonia","url":"https://www.academia.edu/Documents/in/Dystonia?f_ri=2214"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=2214"},{"id":251019,"name":"Haloperidol","url":"https://www.academia.edu/Documents/in/Haloperidol?f_ri=2214"},{"id":253554,"name":"Mismatch Negativity","url":"https://www.academia.edu/Documents/in/Mismatch_Negativity?f_ri=2214"},{"id":298288,"name":"Baclofen","url":"https://www.academia.edu/Documents/in/Baclofen?f_ri=2214"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=2214"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=2214"},{"id":383087,"name":"Globus Pallidus","url":"https://www.academia.edu/Documents/in/Globus_Pallidus?f_ri=2214"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats?f_ri=2214"},{"id":969578,"name":"Single Unit Recording","url":"https://www.academia.edu/Documents/in/Single_Unit_Recording?f_ri=2214"},{"id":994239,"name":"Transgenic Mouse Technology","url":"https://www.academia.edu/Documents/in/Transgenic_Mouse_Technology?f_ri=2214"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=2214"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity?f_ri=2214"},{"id":2367569,"name":"Excitatory Postsynaptic Potentials","url":"https://www.academia.edu/Documents/in/Excitatory_Postsynaptic_Potentials?f_ri=2214"},{"id":2410542,"name":"Dopamine antagonists","url":"https://www.academia.edu/Documents/in/Dopamine_antagonists?f_ri=2214"},{"id":2428413,"name":"Acoustic Stimulation","url":"https://www.academia.edu/Documents/in/Acoustic_Stimulation?f_ri=2214"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42943363" data-work_id="42943363" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42943363/Disentangling_the_Neural_Basis_of_Cognitive_Behavioral_Therapy_in_Psychiatric_Disorders_A_Focus_on_Depression">Disentangling the Neural Basis of Cognitive Behavioral Therapy in Psychiatric Disorders: A Focus on Depression</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Major depressive disorder (MDD) stands among the most frequent psychiatric disorders. Cognitive behavioral therapy (CBT) has been shown to be effective for treating depression, yet its neural mechanisms of action are not well... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_42943363" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Major depressive disorder (MDD) stands among the most frequent psychiatric disorders. Cognitive behavioral therapy (CBT) has been shown to be effective for treating depression, yet its neural mechanisms of action are not well elucidated. The objective of this work is to assess the available neuroimaging studies exploring CBT's effects in adult patients with MDD. Methods: Computerized databases were consulted till April 2018 and a research was conducted according to PRISMA guidelines in order to identify original research articles published at any time in English and French languages on this topic. Results: Seventeen studies were identified. Only one study was randomized comparing CBT to pharmacological interventions, and none included an effective control. Following CBT, changes occurred in cerebral areas that are part of the fronto-limbic system, namely the cingulate cortex, prefrontal cortex and amygdala-hippocampal complex. However, the pattern of activation and connectivity in these areas varied across the studies. Conclusion: A considerable heterogeneity exists with regard to study design, adapted CBT type and intensity, and employed neuroimaging paradigms, all of which may partly explain the difference in studies' outcomes. The lack of randomization and effective controls in most of them makes it difficult to draw formal conclusion whether the observed effects are CBT mediated or due to spontaneous recovery. Despite the observed inconsistencies and dearth of data, CBT appears to exert its anti-depressant effects mainly by modulating the function of affective and cognitive networks devoted to emotions generation and control, respectively. This concept remains to be validated in large scale randomized controlled trials.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42943363" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="22211a90568d8905a5affbdfefaf053e" rel="nofollow" data-download="{"attachment_id":63197331,"asset_id":42943363,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/63197331/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52998441" href="https://lau.academia.edu/MoussaAntoineCHALAH">Moussa Antoine CHALAH</a><script data-card-contents-for-user="52998441" type="text/json">{"id":52998441,"first_name":"Moussa Antoine","last_name":"CHALAH","domain_name":"lau","page_name":"MoussaAntoineCHALAH","display_name":"Moussa Antoine CHALAH","profile_url":"https://lau.academia.edu/MoussaAntoineCHALAH?f_ri=2214","photo":"https://0.academia-photos.com/52998441/14010988/34717125/s65_moussa_antoine.chalah.jpg"}</script></span></span></li><li class="js-paper-rank-work_42943363 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42943363"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42943363, container: ".js-paper-rank-work_42943363", }); 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$(".js-view-count[data-work-id=42943363]").text(description); $(".js-view-count-work_42943363").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42943363").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42943363"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="230" href="https://www.academia.edu/Documents/in/Cognitive_Behavioral_Therapy">Cognitive Behavioral Therapy</a>, <script data-card-contents-for-ri="230" type="text/json">{"id":230,"name":"Cognitive Behavioral Therapy","url":"https://www.academia.edu/Documents/in/Cognitive_Behavioral_Therapy?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2214" href="https://www.academia.edu/Documents/in/Neurobiology_Of_Disease">Neurobiology Of Disease</a>, <script data-card-contents-for-ri="2214" type="text/json">{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3217" href="https://www.academia.edu/Documents/in/Depression">Depression</a><script data-card-contents-for-ri="3217" type="text/json">{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42943363]'), work: {"id":42943363,"title":"Disentangling the Neural Basis of Cognitive Behavioral Therapy in Psychiatric Disorders: A Focus on Depression","created_at":"2020-05-04T16:04:28.446-07:00","url":"https://www.academia.edu/42943363/Disentangling_the_Neural_Basis_of_Cognitive_Behavioral_Therapy_in_Psychiatric_Disorders_A_Focus_on_Depression?f_ri=2214","dom_id":"work_42943363","summary":"Background: Major depressive disorder (MDD) stands among the most frequent psychiatric disorders. Cognitive behavioral therapy (CBT) has been shown to be effective for treating depression, yet its neural mechanisms of action are not well elucidated. The objective of this work is to assess the available neuroimaging studies exploring CBT's effects in adult patients with MDD. Methods: Computerized databases were consulted till April 2018 and a research was conducted according to PRISMA guidelines in order to identify original research articles published at any time in English and French languages on this topic. Results: Seventeen studies were identified. Only one study was randomized comparing CBT to pharmacological interventions, and none included an effective control. Following CBT, changes occurred in cerebral areas that are part of the fronto-limbic system, namely the cingulate cortex, prefrontal cortex and amygdala-hippocampal complex. However, the pattern of activation and connectivity in these areas varied across the studies. Conclusion: A considerable heterogeneity exists with regard to study design, adapted CBT type and intensity, and employed neuroimaging paradigms, all of which may partly explain the difference in studies' outcomes. The lack of randomization and effective controls in most of them makes it difficult to draw formal conclusion whether the observed effects are CBT mediated or due to spontaneous recovery. Despite the observed inconsistencies and dearth of data, CBT appears to exert its anti-depressant effects mainly by modulating the function of affective and cognitive networks devoted to emotions generation and control, respectively. This concept remains to be validated in large scale randomized controlled trials.","downloadable_attachments":[{"id":63197331,"asset_id":42943363,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":52998441,"first_name":"Moussa Antoine","last_name":"CHALAH","domain_name":"lau","page_name":"MoussaAntoineCHALAH","display_name":"Moussa Antoine CHALAH","profile_url":"https://lau.academia.edu/MoussaAntoineCHALAH?f_ri=2214","photo":"https://0.academia-photos.com/52998441/14010988/34717125/s65_moussa_antoine.chalah.jpg"}],"research_interests":[{"id":230,"name":"Cognitive Behavioral Therapy","url":"https://www.academia.edu/Documents/in/Cognitive_Behavioral_Therapy?f_ri=2214","nofollow":false},{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false},{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=2214","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_60616531" data-work_id="60616531" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/60616531/Health_Medicine_Pharmacy_Student_Library_Volume_1_Textbooks_by_First_Author">Health -Medicine -Pharmacy Student Library; Volume 1 Textbooks by First Author</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Summary: Textbook suggestions for a student library on Health-Medicine-Pharmacy, alphabetically listed by First Author. Each textbook has been checked (see -c after book title) for Author Names, Publication Year, Book Title, Publisher,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_60616531" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Summary: Textbook suggestions for a student library on Health-Medicine-Pharmacy, alphabetically listed by First Author. Each textbook has been checked (see -c after book title) for Author Names, Publication Year, Book Title, Publisher, and for Book Cover, Title Page, Copyright Page, Table of Contents, and Subject Index. If missing, such pages have been added where available. All textbooks are .pdf, unless marked by djvu,  epub,  or  chm  after the title. To find books with a particular key word/subject in the book title, please use the Search Function of your computer on this document.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/60616531" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9dde502028e81460b1f010b27364459a" rel="nofollow" data-download="{"attachment_id":73980303,"asset_id":60616531,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73980303/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5470642" href="https://hasdenbosch.academia.edu/JanwillemRouweler">Janwillem Rouweler</a><script data-card-contents-for-user="5470642" type="text/json">{"id":5470642,"first_name":"Janwillem","last_name":"Rouweler","domain_name":"hasdenbosch","page_name":"JanwillemRouweler","display_name":"Janwillem Rouweler","profile_url":"https://hasdenbosch.academia.edu/JanwillemRouweler?f_ri=2214","photo":"https://0.academia-photos.com/5470642/2401819/2795628/s65_janwillem.rouweler.jpg"}</script></span></span></li><li class="js-paper-rank-work_60616531 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="60616531"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 60616531, container: ".js-paper-rank-work_60616531", }); 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$(".js-view-count[data-work-id=60616531]").text(description); $(".js-view-count-work_60616531").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_60616531").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="60616531"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="607" href="https://www.academia.edu/Documents/in/Emergency_Medicine">Emergency Medicine</a>, <script data-card-contents-for-ri="607" type="text/json">{"id":607,"name":"Emergency Medicine","url":"https://www.academia.edu/Documents/in/Emergency_Medicine?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="620" href="https://www.academia.edu/Documents/in/Internal_Medicine_General_Medicine_">Internal Medicine (General Medicine)</a>, <script data-card-contents-for-ri="620" type="text/json">{"id":620,"name":"Internal Medicine (General Medicine)","url":"https://www.academia.edu/Documents/in/Internal_Medicine_General_Medicine_?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="647" href="https://www.academia.edu/Documents/in/Surgery">Surgery</a>, <script data-card-contents-for-ri="647" type="text/json">{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="656" href="https://www.academia.edu/Documents/in/Pharmacy">Pharmacy</a><script data-card-contents-for-ri="656" type="text/json">{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=60616531]'), work: {"id":60616531,"title":"Health -Medicine -Pharmacy Student Library; Volume 1 Textbooks by First Author","created_at":"2021-10-31T18:04:57.993-07:00","url":"https://www.academia.edu/60616531/Health_Medicine_Pharmacy_Student_Library_Volume_1_Textbooks_by_First_Author?f_ri=2214","dom_id":"work_60616531","summary":"Summary: Textbook suggestions for a student library on Health-Medicine-Pharmacy, alphabetically listed by First Author. Each textbook has been checked (see -c after book title) for Author Names, Publication Year, Book Title, Publisher, and for Book Cover, Title Page, Copyright Page, Table of Contents, and Subject Index. If missing, such pages have been added where available. All textbooks are .pdf, unless marked by djvu, epub, or chm after the title. To find books with a particular key word/subject in the book title, please use the Search Function of your computer on this document.","downloadable_attachments":[{"id":73980303,"asset_id":60616531,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5470642,"first_name":"Janwillem","last_name":"Rouweler","domain_name":"hasdenbosch","page_name":"JanwillemRouweler","display_name":"Janwillem Rouweler","profile_url":"https://hasdenbosch.academia.edu/JanwillemRouweler?f_ri=2214","photo":"https://0.academia-photos.com/5470642/2401819/2795628/s65_janwillem.rouweler.jpg"}],"research_interests":[{"id":607,"name":"Emergency Medicine","url":"https://www.academia.edu/Documents/in/Emergency_Medicine?f_ri=2214","nofollow":false},{"id":620,"name":"Internal Medicine (General Medicine)","url":"https://www.academia.edu/Documents/in/Internal_Medicine_General_Medicine_?f_ri=2214","nofollow":false},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=2214","nofollow":false},{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy?f_ri=2214","nofollow":false},{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214"},{"id":2827,"name":"Mental Health","url":"https://www.academia.edu/Documents/in/Mental_Health?f_ri=2214"},{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=2214"},{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=2214"},{"id":6533,"name":"Hospice \u0026 Palliative Care Nursing","url":"https://www.academia.edu/Documents/in/Hospice_and_Palliative_Care_Nursing?f_ri=2214"},{"id":6535,"name":"Psychiatric \u0026 Mental Health Nursing","url":"https://www.academia.edu/Documents/in/Psychiatric_and_Mental_Health_Nursing?f_ri=2214"},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=2214"},{"id":11558,"name":"Drug interactions","url":"https://www.academia.edu/Documents/in/Drug_interactions?f_ri=2214"},{"id":57294,"name":"Nursing Research","url":"https://www.academia.edu/Documents/in/Nursing_Research?f_ri=2214"},{"id":67366,"name":"Occupational health and safety","url":"https://www.academia.edu/Documents/in/Occupational_health_and_safety-2?f_ri=2214"},{"id":81309,"name":"Infectious Disease","url":"https://www.academia.edu/Documents/in/Infectious_Disease?f_ri=2214"},{"id":84945,"name":"Pharmacology and Clinical pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacology_and_Clinical_pharmacy?f_ri=2214"},{"id":105212,"name":"Pharmacy Education","url":"https://www.academia.edu/Documents/in/Pharmacy_Education?f_ri=2214"},{"id":127605,"name":"Health Science","url":"https://www.academia.edu/Documents/in/Health_Science?f_ri=2214"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems?f_ri=2214"},{"id":992395,"name":"Medicine and Science In Sports and Exercise","url":"https://www.academia.edu/Documents/in/Medicine_and_Science_In_Sports_and_Exercise?f_ri=2214"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_3393872" data-work_id="3393872" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/3393872/Addicted_to_love_What_is_love_addiction_and_when_should_it_be_treated">Addicted to love: What is love addiction and when should it be treated? </a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Recent research suggests that romantic love may be literally addictive. Although the exact nature of the relationship between love and addiction has been described in inconsistent terms throughout the literature, we offer a framework that... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_3393872" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Recent research suggests that romantic love may be literally addictive. Although the exact nature of the relationship between love and addiction has been described in inconsistent terms throughout the literature, we offer a framework that distinguishes between a narrow view and a broad view of love addiction. The narrow view counts only the most extreme, harmful forms of love or love-related behaviors as being potentially addictive in nature. The broad view, by contrast, counts even basic social attachment as being on a spectrum of addictive motivations, underwritten by similar neurochemical processes as more conventional addictions. We argue that on either understanding of love-as-addiction, treatment decisions should hinge on considerations of harm and well-being rather than on definitions of disease. Implications for the ethical use of anti-love biotechnology are considered.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/3393872" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="686ed0b177e8718a348b54b2173eb997" rel="nofollow" data-download="{"attachment_id":51854297,"asset_id":3393872,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51854297/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="377433" href="https://oxford.academia.edu/BrianDEarp">Brian D . Earp</a><script data-card-contents-for-user="377433" type="text/json">{"id":377433,"first_name":"Brian","last_name":"Earp","domain_name":"oxford","page_name":"BrianDEarp","display_name":"Brian D . Earp","profile_url":"https://oxford.academia.edu/BrianDEarp?f_ri=2214","photo":"https://0.academia-photos.com/377433/97125/157103608/s65_brian_d..earp.jpg"}</script></span></span></li><li class="js-paper-rank-work_3393872 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="3393872"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 3393872, container: ".js-paper-rank-work_3393872", }); });</script></li><li class="js-percentile-work_3393872 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3393872; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_3393872"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_3393872 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="3393872"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3393872; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3393872]").text(description); $(".js-view-count-work_3393872").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_3393872").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="3393872"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">203</a>  </div><span class="InlineList-item-text u-textTruncate u-pl11x"><a class="InlineList-item-text" data-has-card-for-ri="46" href="https://www.academia.edu/Documents/in/Business_Ethics">Business Ethics</a>, <script data-card-contents-for-ri="46" type="text/json">{"id":46,"name":"Business Ethics","url":"https://www.academia.edu/Documents/in/Business_Ethics?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="128" href="https://www.academia.edu/Documents/in/History">History</a>, <script data-card-contents-for-ri="128" type="text/json">{"id":128,"name":"History","url":"https://www.academia.edu/Documents/in/History?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="136" href="https://www.academia.edu/Documents/in/Cultural_History">Cultural History</a>, <script data-card-contents-for-ri="136" type="text/json">{"id":136,"name":"Cultural History","url":"https://www.academia.edu/Documents/in/Cultural_History?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="140" href="https://www.academia.edu/Documents/in/Pharmacology">Pharmacology</a><script data-card-contents-for-ri="140" type="text/json">{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3393872]'), work: {"id":3393872,"title":"Addicted to love: What is love addiction and when should it be treated? ","created_at":"2013-04-26T06:27:23.343-07:00","url":"https://www.academia.edu/3393872/Addicted_to_love_What_is_love_addiction_and_when_should_it_be_treated?f_ri=2214","dom_id":"work_3393872","summary":"Recent research suggests that romantic love may be literally addictive. Although the exact nature of the relationship between love and addiction has been described in inconsistent terms throughout the literature, we offer a framework that distinguishes between a narrow view and a broad view of love addiction. The narrow view counts only the most extreme, harmful forms of love or love-related behaviors as being potentially addictive in nature. The broad view, by contrast, counts even basic social attachment as being on a spectrum of addictive motivations, underwritten by similar neurochemical processes as more conventional addictions. We argue that on either understanding of love-as-addiction, treatment decisions should hinge on considerations of harm and well-being rather than on definitions of disease. Implications for the ethical use of anti-love biotechnology are considered.","downloadable_attachments":[{"id":51854297,"asset_id":3393872,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":377433,"first_name":"Brian","last_name":"Earp","domain_name":"oxford","page_name":"BrianDEarp","display_name":"Brian D . 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Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology?f_ri=2214"},{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience?f_ri=2214"},{"id":184,"name":"Sociology","url":"https://www.academia.edu/Documents/in/Sociology?f_ri=2214"},{"id":201,"name":"Political Sociology","url":"https://www.academia.edu/Documents/in/Political_Sociology?f_ri=2214"},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=2214"},{"id":226,"name":"Clinical Psychology","url":"https://www.academia.edu/Documents/in/Clinical_Psychology?f_ri=2214"},{"id":230,"name":"Cognitive Behavioral Therapy","url":"https://www.academia.edu/Documents/in/Cognitive_Behavioral_Therapy?f_ri=2214"},{"id":231,"name":"Family Therapy","url":"https://www.academia.edu/Documents/in/Family_Therapy?f_ri=2214"},{"id":236,"name":"Cognitive Psychology","url":"https://www.academia.edu/Documents/in/Cognitive_Psychology?f_ri=2214"},{"id":237,"name":"Cognitive 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Soekadar","profile_url":"https://uni-tuebingen1.academia.edu/SurjoSoekadar?f_ri=2214","photo":"https://0.academia-photos.com/41575214/11261174/12564494/s65_surjo.soekadar.jpg"}],"research_interests":[{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=2214","nofollow":false},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=2214","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16884288 coauthored" data-work_id="16884288" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16884288/Insulin_resistance_in_Alzheimers_disease">Insulin resistance in Alzheimer's disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Insulin is a key hormone regulating metabolism. Insulin binding to cell surface insulin receptors engages many signaling intermediates operating in parallel and in series to control glucose, energy, and lipids while also regulating... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16884288" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Insulin is a key hormone regulating metabolism. Insulin binding to cell surface insulin receptors engages many signaling intermediates operating in parallel and in series to control glucose, energy, and lipids while also regulating mitogenesis and development. Perturbations in the function of any of these intermediates, which occur in a variety of diseases, cause reduced sensitivity to insulin and insulin resistance with consequent metabolic dysfunction. Chronic inflammation ensues which exacerbates compromised metabolic homeostasis. Since insulin has a key role in learning and memory as well as directly regulating ERK, a kinase required for the type of learning and memory compromised in early Alzheimer&amp;amp;amp;amp;amp;#39;s disease (AD), insulin resistance has been identified as a major risk factor for the onset of AD. Animal models of AD or insulin resistance or both demonstrate that AD pathology and impaired insulin signaling form a reciprocal relationship. Of note are human and animal model studies geared toward improving insulin resistance that have led to the identification of the nuclear receptor and transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) as an intervention tool for early AD. Strategic targeting of alternate nodes within the insulin signaling network has revealed disease-stage therapeutic windows in animal models that coalesce with previous and ongoing clinical trial approaches. Thus, exploiting the connection between insulin resistance and AD provides powerful opportunities to delineate therapeutic interventions that slow or block the pathogenesis of AD.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16884288" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a5030f50262618399c393919c453994c" rel="nofollow" data-download="{"attachment_id":42379689,"asset_id":16884288,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42379689/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36761509" href="https://independent.academia.edu/LDenner">L. Denner</a><script data-card-contents-for-user="36761509" type="text/json">{"id":36761509,"first_name":"L.","last_name":"Denner","domain_name":"independent","page_name":"LDenner","display_name":"L. Denner","profile_url":"https://independent.academia.edu/LDenner?f_ri=2214","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16884288">+2</span><div class="hidden js-additional-users-16884288"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/KellyDineley">Kelly Dineley</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://uthscsa.academia.edu/JJahrling">J. Jahrling</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16884288'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16884288').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_16884288 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16884288"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16884288, container: ".js-paper-rank-work_16884288", }); });</script></li><li class="js-percentile-work_16884288 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16884288; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16884288"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16884288 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16884288"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16884288; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16884288]").text(description); $(".js-view-count-work_16884288").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16884288").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16884288"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2214" href="https://www.academia.edu/Documents/in/Neurobiology_Of_Disease">Neurobiology Of Disease</a>, <script data-card-contents-for-ri="2214" type="text/json">{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="43774" href="https://www.academia.edu/Documents/in/Learning">Learning</a>, <script data-card-contents-for-ri="43774" type="text/json">{"id":43774,"name":"Learning","url":"https://www.academia.edu/Documents/in/Learning?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="51373" href="https://www.academia.edu/Documents/in/Insulin_Resistance">Insulin Resistance</a>, <script data-card-contents-for-ri="51373" type="text/json">{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" href="https://www.academia.edu/Documents/in/Brain">Brain</a><script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16884288]'), work: {"id":16884288,"title":"Insulin resistance in Alzheimer's disease","created_at":"2015-10-16T12:09:23.894-07:00","url":"https://www.academia.edu/16884288/Insulin_resistance_in_Alzheimers_disease?f_ri=2214","dom_id":"work_16884288","summary":"Insulin is a key hormone regulating metabolism. Insulin binding to cell surface insulin receptors engages many signaling intermediates operating in parallel and in series to control glucose, energy, and lipids while also regulating mitogenesis and development. Perturbations in the function of any of these intermediates, which occur in a variety of diseases, cause reduced sensitivity to insulin and insulin resistance with consequent metabolic dysfunction. Chronic inflammation ensues which exacerbates compromised metabolic homeostasis. Since insulin has a key role in learning and memory as well as directly regulating ERK, a kinase required for the type of learning and memory compromised in early Alzheimer\u0026amp;amp;amp;amp;amp;#39;s disease (AD), insulin resistance has been identified as a major risk factor for the onset of AD. Animal models of AD or insulin resistance or both demonstrate that AD pathology and impaired insulin signaling form a reciprocal relationship. Of note are human and animal model studies geared toward improving insulin resistance that have led to the identification of the nuclear receptor and transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) as an intervention tool for early AD. Strategic targeting of alternate nodes within the insulin signaling network has revealed disease-stage therapeutic windows in animal models that coalesce with previous and ongoing clinical trial approaches. Thus, exploiting the connection between insulin resistance and AD provides powerful opportunities to delineate therapeutic interventions that slow or block the pathogenesis of AD.","downloadable_attachments":[{"id":42379689,"asset_id":16884288,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36761509,"first_name":"L.","last_name":"Denner","domain_name":"independent","page_name":"LDenner","display_name":"L. Denner","profile_url":"https://independent.academia.edu/LDenner?f_ri=2214","photo":"/images/s65_no_pic.png"},{"id":36363272,"first_name":"Kelly","last_name":"Dineley","domain_name":"independent","page_name":"KellyDineley","display_name":"Kelly Dineley","profile_url":"https://independent.academia.edu/KellyDineley?f_ri=2214","photo":"/images/s65_no_pic.png"},{"id":36627993,"first_name":"J.","last_name":"Jahrling","domain_name":"uthscsa","page_name":"JJahrling","display_name":"J. Jahrling","profile_url":"https://uthscsa.academia.edu/JJahrling?f_ri=2214","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false},{"id":43774,"name":"Learning","url":"https://www.academia.edu/Documents/in/Learning?f_ri=2214","nofollow":false},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance?f_ri=2214","nofollow":false},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=2214","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=2214"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin?f_ri=2214"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=2214"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=2214"},{"id":1109079,"name":"Encephalitis","url":"https://www.academia.edu/Documents/in/Encephalitis?f_ri=2214"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease?f_ri=2214"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=2214"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_455869" data-work_id="455869" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/455869/The_Collaborative_Patient_Person_Centric_Care_Model_CPCCM_Introducing_a_new_paradigm_in_patient_care_involving_an_evidence_informed_approach_Canadian_Healthcare_Network_EPublished_7_March_2011_http_www_canadianhealthcarenetwork_ca_">The Collaborative Patient/Person-Centric Care Model (CPCCM) Introducing a new paradigm in patient care involving an evidence-informed approach. Canadian Healthcare Network. EPublished 7 March 2011. http://www.canadianhealthcarenetwork.ca/</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">"Patient care has traditionally been guided by the conventional paradigm known as the medical or biomedical model, whose roots can be traced back to the era of reductionism and mind-body dualism, which separates the mental from the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_455869" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">"Patient care has traditionally been guided by the conventional paradigm known as the medical or biomedical model, whose roots can be traced back to the era of reductionism and mind-body dualism, which separates the mental from the somatic. (Engel, 1977) In this model, disease is defined as a biophysical malfunction. (Engel, 1977) In the biomedical model, the goal of treatment is to correct the malfunction in order to cure the disease. (Engel, 1977) As such, this traditional medical model places the pathophysiology of the disease, objective tests, and therapeutic interventions at the centre of patient care. (McCollum, 2009) Such a model offers a one-dimensional approach to patient care that excludes the patient experience of illness and how this might impact other facets of the patient’s life (e.g., work disability, finances, social networks, etc.) because they are believed to lie outside of medicine’s responsibility and authority. (McCollum, 2009; Engel, 1977)<br /><br />By incorporating other psychological (e.g., thoughts, emotions, behaviors) and social dimensions of the patient into the care plan, one moves towards the bio-psycho-social (BPS) model of patient care. (Phelps, 2009) The BPS model was first theorized by a psychiatrist, Dr. George L. Engel, in 1977. (Engel, 1977) In the BPS model, patient care is based on the belief that psychological and social dimensions also contribute significantly to human functioning within the context of disease or illness and, as such, need to be considered when providing care to a patient. (Engel, 1977) Specifically, the biological component examines the cause of the illness and how it affects the functioning of the body. (Engel, 1977) The psychological component of the model explores any potential psychological causes for the illness (e.g., lack of self-control, emotional stressors, negative-thinking, etc.). (Engel, 1977) Finally, the social component considers how different social factors (e.g., socioeconomic status, religion, culture, etc.) impact illness. (Engel, 1977) In order to address all aspects of this three-dimensional model, an integrated team approach involving allied healthcare professionals such as physicians, nurses, psychologists, pharmacists, social workers, and rehabilitation specialists are critical for ensuring that more comprehensive patient care is provided. (Phelps, 2009) Overall, the underlying premise of the BPS model is that the body and mind are intricately connected and what affects one will affect the other. (Halligan, 2006; Freudenreich, 2010) However, while this model advances patient care and can address the dis-ease that exists within the disease, it still does not encompass the patient as a “whole” and consider all the multitude of facets that make up the individual.<br /><br />An alternative model to the biomedical and BPS model of care is the recovery model. In the recovery model, the patient is involved in a lifelong recovery process that involves a number of incremental steps across various facets of his or her life. (Turton, 2010) Moreover, the primary illness is seen as only one dimension in the patient’s recovery process. (Turton, 2010) Other key aspects of this model include negotiating treatment approaches between patients and practitioners such that the patient feels empowered. (Turton, 2010) Moreover, this model enables patients to regain their dignity and identity beyond the illness. (Turton, 2010) As such, this model takes the BPS model and advances it forward to include other patient dimensions in the provision of their care. Thus, the underlying ethos of this model for the patient is one of hope and optimism. (Turton, 2010)<br /><br />A recent study conducted in ten European countries aimed to examine the recovery model of patient care in order to identify aspects of care that key stakeholders believed to be most important in the promoting recovery, specifically in patients with mental illness. (Turton, 2010) Eleven important domains of care identified by stakeholders in this study included: (1) social policy and human rights, (2) social inclusion, (3) self-management and autonomy, (4) therapeutic interventions, (5) governance, (6) staffing, (7) staff attitudes, (8) institutional environment, (9) post-discharge care, (10) caregivers, and (11) physical health care. (Turton, 2010) The authors also found that there was generally a high consensus between groups and countries with some modest differences in priorities noted. (Turton, 2010) Interesting, the most highly rated aspect of care was therapeutic interventions, a central piece of the more traditional medical model of care. (Turton, 2010) The authors suggest that stakeholders may still hold therapeutic interventions as the most important aspect of care because such interventions form the foundation and ‘raison d’être’ of health care. (Turton, 2010) Thus, it may be difficult for practitioners to step away from convention and embrace a new paradigm.<br /><br />Incorporating various aspects of the BPS and recovery model of patient care, a patient-centered care (PCC) model has evolved over the last several years to replace the conventional biomedical model of care. (Laird-Fick, 2010) The Institute of Medicine (IOM) has stated that embracing a PCC model will help to close the “quality chasm” often present in the care provided to patients. (IOM, 2001) In a PCC model, the patient’s individuality is central. (Wolf, 2008) The patient has the right to have his or her needs, desires, beliefs, values, and goals respected and placed at the centre of the care plan. (Laird-Fick, 2010; Wolf, 2008) Such respect of the patient’s individuality is part of the team’s commitment to understand the patient’s perspective of his or her own health status and subsequent care. (Wolf, 2008) The underlying ethos of this model of care is that the patient has the right to respect, dignity, and care that focuses on the person and situation versus the disease process. (Wolf, 2008)<br /><br />Our hypothesis is that the medical and bio-psycho-social models act as an essential foundation on which a more patient functionality centered model evolves: the Collaborative Patient/Person-Centric Care Model (CPCCM). This has a paradigm shift in the deliverables of patient care which involves talking to patients and family, listening to their desired outcomes, collaborating with allied health team members in order to help facilitate these patient goals, and finally formulating an individualized care plan that combines the patient’s wishes with the clinical endpoints derived from a uniform therapeutic thought process. The root of this theory is enmeshed in goal driven outcomes, as are the other models. However the goal is driven by the patient and then filtered through the professional lenses of the members of the treating team versus the converse. This evidence-informed versus evidence-based approach is more patient centric than when outcomes are determined independently by clinicians in a traditional hierarchical structure. This also allows the current structure to be realigned along a linear axis. (Lamoure 2008)" Joel Lamoure, Jessica Stovel, Matthew Piamonte et al.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/455869" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ac62df437108034311a84bf185410e8a" rel="nofollow" data-download="{"attachment_id":4604142,"asset_id":455869,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/4604142/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35459" href="https://westernu.academia.edu/JoelLamoure">Joel Lamoure</a><script data-card-contents-for-user="35459" type="text/json">{"id":35459,"first_name":"Joel","last_name":"Lamoure","domain_name":"westernu","page_name":"JoelLamoure","display_name":"Joel Lamoure","profile_url":"https://westernu.academia.edu/JoelLamoure?f_ri=2214","photo":"https://0.academia-photos.com/35459/11696/1750028/s65_dr._joel.lamoure.jpg"}</script></span></span></li><li class="js-paper-rank-work_455869 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="455869"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 455869, container: ".js-paper-rank-work_455869", }); 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$(".js-view-count[data-work-id=455869]").text(description); $(".js-view-count-work_455869").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_455869").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="455869"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="248" href="https://www.academia.edu/Documents/in/Social_Psychology">Social Psychology</a>, <script data-card-contents-for-ri="248" type="text/json">{"id":248,"name":"Social Psychology","url":"https://www.academia.edu/Documents/in/Social_Psychology?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="260" href="https://www.academia.edu/Documents/in/Health_Psychology">Health Psychology</a>, <script data-card-contents-for-ri="260" type="text/json">{"id":260,"name":"Health Psychology","url":"https://www.academia.edu/Documents/in/Health_Psychology?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="588" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a><script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=455869]'), work: {"id":455869,"title":"The Collaborative Patient/Person-Centric Care Model (CPCCM) Introducing a new paradigm in patient care involving an evidence-informed approach. Canadian Healthcare Network. EPublished 7 March 2011. http://www.canadianhealthcarenetwork.ca/","created_at":"2011-02-25T05:49:08.636-08:00","url":"https://www.academia.edu/455869/The_Collaborative_Patient_Person_Centric_Care_Model_CPCCM_Introducing_a_new_paradigm_in_patient_care_involving_an_evidence_informed_approach_Canadian_Healthcare_Network_EPublished_7_March_2011_http_www_canadianhealthcarenetwork_ca_?f_ri=2214","dom_id":"work_455869","summary":"\"Patient care has traditionally been guided by the conventional paradigm known as the medical or biomedical model, whose roots can be traced back to the era of reductionism and mind-body dualism, which separates the mental from the somatic. (Engel, 1977) In this model, disease is defined as a biophysical malfunction. (Engel, 1977) In the biomedical model, the goal of treatment is to correct the malfunction in order to cure the disease. (Engel, 1977) As such, this traditional medical model places the pathophysiology of the disease, objective tests, and therapeutic interventions at the centre of patient care. (McCollum, 2009) Such a model offers a one-dimensional approach to patient care that excludes the patient experience of illness and how this might impact other facets of the patient’s life (e.g., work disability, finances, social networks, etc.) because they are believed to lie outside of medicine’s responsibility and authority. (McCollum, 2009; Engel, 1977)\n\nBy incorporating other psychological (e.g., thoughts, emotions, behaviors) and social dimensions of the patient into the care plan, one moves towards the bio-psycho-social (BPS) model of patient care. (Phelps, 2009) The BPS model was first theorized by a psychiatrist, Dr. George L. Engel, in 1977. (Engel, 1977) In the BPS model, patient care is based on the belief that psychological and social dimensions also contribute significantly to human functioning within the context of disease or illness and, as such, need to be considered when providing care to a patient. (Engel, 1977) Specifically, the biological component examines the cause of the illness and how it affects the functioning of the body. (Engel, 1977) The psychological component of the model explores any potential psychological causes for the illness (e.g., lack of self-control, emotional stressors, negative-thinking, etc.). (Engel, 1977) Finally, the social component considers how different social factors (e.g., socioeconomic status, religion, culture, etc.) impact illness. (Engel, 1977) In order to address all aspects of this three-dimensional model, an integrated team approach involving allied healthcare professionals such as physicians, nurses, psychologists, pharmacists, social workers, and rehabilitation specialists are critical for ensuring that more comprehensive patient care is provided. (Phelps, 2009) Overall, the underlying premise of the BPS model is that the body and mind are intricately connected and what affects one will affect the other. (Halligan, 2006; Freudenreich, 2010) However, while this model advances patient care and can address the dis-ease that exists within the disease, it still does not encompass the patient as a “whole” and consider all the multitude of facets that make up the individual.\n\nAn alternative model to the biomedical and BPS model of care is the recovery model. In the recovery model, the patient is involved in a lifelong recovery process that involves a number of incremental steps across various facets of his or her life. (Turton, 2010) Moreover, the primary illness is seen as only one dimension in the patient’s recovery process. (Turton, 2010) Other key aspects of this model include negotiating treatment approaches between patients and practitioners such that the patient feels empowered. (Turton, 2010) Moreover, this model enables patients to regain their dignity and identity beyond the illness. (Turton, 2010) As such, this model takes the BPS model and advances it forward to include other patient dimensions in the provision of their care. Thus, the underlying ethos of this model for the patient is one of hope and optimism. (Turton, 2010)\n\nA recent study conducted in ten European countries aimed to examine the recovery model of patient care in order to identify aspects of care that key stakeholders believed to be most important in the promoting recovery, specifically in patients with mental illness. (Turton, 2010) Eleven important domains of care identified by stakeholders in this study included: (1) social policy and human rights, (2) social inclusion, (3) self-management and autonomy, (4) therapeutic interventions, (5) governance, (6) staffing, (7) staff attitudes, (8) institutional environment, (9) post-discharge care, (10) caregivers, and (11) physical health care. (Turton, 2010) The authors also found that there was generally a high consensus between groups and countries with some modest differences in priorities noted. (Turton, 2010) Interesting, the most highly rated aspect of care was therapeutic interventions, a central piece of the more traditional medical model of care. (Turton, 2010) The authors suggest that stakeholders may still hold therapeutic interventions as the most important aspect of care because such interventions form the foundation and ‘raison d’être’ of health care. (Turton, 2010) Thus, it may be difficult for practitioners to step away from convention and embrace a new paradigm.\n\nIncorporating various aspects of the BPS and recovery model of patient care, a patient-centered care (PCC) model has evolved over the last several years to replace the conventional biomedical model of care. (Laird-Fick, 2010) The Institute of Medicine (IOM) has stated that embracing a PCC model will help to close the “quality chasm” often present in the care provided to patients. (IOM, 2001) In a PCC model, the patient’s individuality is central. (Wolf, 2008) The patient has the right to have his or her needs, desires, beliefs, values, and goals respected and placed at the centre of the care plan. (Laird-Fick, 2010; Wolf, 2008) Such respect of the patient’s individuality is part of the team’s commitment to understand the patient’s perspective of his or her own health status and subsequent care. (Wolf, 2008) The underlying ethos of this model of care is that the patient has the right to respect, dignity, and care that focuses on the person and situation versus the disease process. (Wolf, 2008)\n\nOur hypothesis is that the medical and bio-psycho-social models act as an essential foundation on which a more patient functionality centered model evolves: the Collaborative Patient/Person-Centric Care Model (CPCCM). This has a paradigm shift in the deliverables of patient care which involves talking to patients and family, listening to their desired outcomes, collaborating with allied health team members in order to help facilitate these patient goals, and finally formulating an individualized care plan that combines the patient’s wishes with the clinical endpoints derived from a uniform therapeutic thought process. The root of this theory is enmeshed in goal driven outcomes, as are the other models. However the goal is driven by the patient and then filtered through the professional lenses of the members of the treating team versus the converse. This evidence-informed versus evidence-based approach is more patient centric than when outcomes are determined independently by clinicians in a traditional hierarchical structure. This also allows the current structure to be realigned along a linear axis. (Lamoure 2008)\" Joel Lamoure, Jessica Stovel, Matthew Piamonte et al.","downloadable_attachments":[{"id":4604142,"asset_id":455869,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35459,"first_name":"Joel","last_name":"Lamoure","domain_name":"westernu","page_name":"JoelLamoure","display_name":"Joel Lamoure","profile_url":"https://westernu.academia.edu/JoelLamoure?f_ri=2214","photo":"https://0.academia-photos.com/35459/11696/1750028/s65_dr._joel.lamoure.jpg"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=2214","nofollow":false},{"id":248,"name":"Social Psychology","url":"https://www.academia.edu/Documents/in/Social_Psychology?f_ri=2214","nofollow":false},{"id":260,"name":"Health Psychology","url":"https://www.academia.edu/Documents/in/Health_Psychology?f_ri=2214","nofollow":false},{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=2214","nofollow":false},{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy?f_ri=2214"},{"id":940,"name":"Social Work","url":"https://www.academia.edu/Documents/in/Social_Work?f_ri=2214"},{"id":1313,"name":"Mood Disorders (Psychology)","url":"https://www.academia.edu/Documents/in/Mood_Disorders_Psychology_?f_ri=2214"},{"id":1414,"name":"Bioethics","url":"https://www.academia.edu/Documents/in/Bioethics?f_ri=2214"},{"id":2047,"name":"Psychopharmacology","url":"https://www.academia.edu/Documents/in/Psychopharmacology?f_ri=2214"},{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214"},{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=2214"},{"id":3645,"name":"Evidence Based Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=2214"},{"id":5985,"name":"Evidence Based Nursing","url":"https://www.academia.edu/Documents/in/Evidence_Based_Nursing?f_ri=2214"},{"id":21559,"name":"Health Care Management","url":"https://www.academia.edu/Documents/in/Health_Care_Management?f_ri=2214"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=2214"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_530699" data-work_id="530699" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/530699/Does_the_salience_network_play_a_cardinal_role_in_psychosis_An_emerging_hypothesis_of_insular_dysfunction">Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction.</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Abstract Insular cortex is one of the brain regions that show consistent abnormalities in both structural and functional neuroimaging studies in schizophrenia. In healthy individuals insula has been implicated in a myriad of physiological... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_530699" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Abstract<br />Insular cortex is one of the brain regions that show consistent abnormalities in both structural and functional neuroimaging studies in schizophrenia. In healthy individuals insula has been implicated in a myriad of physiological functions. Anterior cingulate cortex and insula together constitute the Salience Network (SN), an intrinsic large-scale network showing strong functional connectivity. Considering insula as a functional unit along with anterior cingulate cortex provides an integrated understanding of the role of insula in information processing. In this review, we bring together evidence from imaging studies to understand the role of salience network in schizophrenia, and propose a model of insular dysfunction in psychosis.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/530699" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9b4d9ef6699711a2381b2cbd2bdced9f" rel="nofollow" data-download="{"attachment_id":3853299,"asset_id":530699,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/3853299/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="297657" href="https://nottingham.academia.edu/LPalaniyappan">Lena Palaniyappan</a><script data-card-contents-for-user="297657" type="text/json">{"id":297657,"first_name":"Lena","last_name":"Palaniyappan","domain_name":"nottingham","page_name":"LPalaniyappan","display_name":"Lena Palaniyappan","profile_url":"https://nottingham.academia.edu/LPalaniyappan?f_ri=2214","photo":"https://0.academia-photos.com/297657/60227/63536/s65_lena.palaniyappan.jpg"}</script></span></span></li><li class="js-paper-rank-work_530699 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="530699"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 530699, container: ".js-paper-rank-work_530699", }); 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$(".js-view-count[data-work-id=530699]").text(description); $(".js-view-count-work_530699").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_530699").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="530699"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1312" href="https://www.academia.edu/Documents/in/Psychosis">Psychosis</a>, <script data-card-contents-for-ri="1312" type="text/json">{"id":1312,"name":"Psychosis","url":"https://www.academia.edu/Documents/in/Psychosis?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2214" href="https://www.academia.edu/Documents/in/Neurobiology_Of_Disease">Neurobiology Of Disease</a>, <script data-card-contents-for-ri="2214" type="text/json">{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2639" href="https://www.academia.edu/Documents/in/Neuroimaging">Neuroimaging</a>, <script data-card-contents-for-ri="2639" type="text/json">{"id":2639,"name":"Neuroimaging","url":"https://www.academia.edu/Documents/in/Neuroimaging?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3227" href="https://www.academia.edu/Documents/in/Schizophrenia">Schizophrenia</a><script data-card-contents-for-ri="3227" type="text/json">{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=530699]'), work: {"id":530699,"title":"Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction.","created_at":"2011-04-15T05:02:25.202-07:00","url":"https://www.academia.edu/530699/Does_the_salience_network_play_a_cardinal_role_in_psychosis_An_emerging_hypothesis_of_insular_dysfunction?f_ri=2214","dom_id":"work_530699","summary":"Abstract\nInsular cortex is one of the brain regions that show consistent abnormalities in both structural and functional neuroimaging studies in schizophrenia. In healthy individuals insula has been implicated in a myriad of physiological functions. Anterior cingulate cortex and insula together constitute the Salience Network (SN), an intrinsic large-scale network showing strong functional connectivity. Considering insula as a functional unit along with anterior cingulate cortex provides an integrated understanding of the role of insula in information processing. In this review, we bring together evidence from imaging studies to understand the role of salience network in schizophrenia, and propose a model of insular dysfunction in psychosis.","downloadable_attachments":[{"id":3853299,"asset_id":530699,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":297657,"first_name":"Lena","last_name":"Palaniyappan","domain_name":"nottingham","page_name":"LPalaniyappan","display_name":"Lena Palaniyappan","profile_url":"https://nottingham.academia.edu/LPalaniyappan?f_ri=2214","photo":"https://0.academia-photos.com/297657/60227/63536/s65_lena.palaniyappan.jpg"}],"research_interests":[{"id":1312,"name":"Psychosis","url":"https://www.academia.edu/Documents/in/Psychosis?f_ri=2214","nofollow":false},{"id":2214,"name":"Neurobiology Of 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href="https://www.academia.edu/15745681/Inhibition_of_soluble_TNF_signaling_in_a_mouse_model_of_Alzheimers_disease_prevents_pre_plaque_amyloid_associated_neuropathology">Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Microglial activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in Alzheimer&#39;s disease (AD). Elevated levels of the pro-inflammatory cytokine tumor necrosis factor (TNF) have... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15745681" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Microglial activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in Alzheimer&#39;s disease (AD). Elevated levels of the pro-inflammatory cytokine tumor necrosis factor (TNF) have been reported in serum and post-mortem brains of patients with AD, but its role in progression of AD is unclear. Using novel engineered dominant negative TNF inhibitors (DN-TNFs) selective</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15745681" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9370cd6c84fad65eac0ed0bbbe7d27a0" rel="nofollow" data-download="{"attachment_id":42911832,"asset_id":15745681,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42911832/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35011164" href="https://independent.academia.edu/MBlurtonjones">M. 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class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5552895" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9a0f13480c1684cdc30bf83fe0901740" rel="nofollow" data-download="{"attachment_id":49245960,"asset_id":5552895,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49245960/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa 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href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2214" href="https://www.academia.edu/Documents/in/Neurobiology_Of_Disease">Neurobiology Of Disease</a>, <script data-card-contents-for-ri="2214" type="text/json">{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2583" href="https://www.academia.edu/Documents/in/Deep_Brain_Stimulation">Deep Brain Stimulation</a><script data-card-contents-for-ri="2583" type="text/json">{"id":2583,"name":"Deep Brain Stimulation","url":"https://www.academia.edu/Documents/in/Deep_Brain_Stimulation?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=5552895]'), work: {"id":5552895,"title":"Deep brain stimulationfor movement disorders","created_at":"2013-12-29T07:46:57.452-08:00","url":"https://www.academia.edu/5552895/Deep_brain_stimulationfor_movement_disorders?f_ri=2214","dom_id":"work_5552895","summary":null,"downloadable_attachments":[{"id":49245960,"asset_id":5552895,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":7880910,"first_name":"Alon","last_name":"Mogilner","domain_name":"med-nyu","page_name":"AlonMogilner","display_name":"Alon 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data-work_id="26939684" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26939684/Nuclear_receptors_in_neurodegenerative_diseases">Nuclear receptors in neurodegenerative diseases</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders. Despite years of effort, effective treatments for progressive neurodegenerative... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_26939684" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders. Despite years of effort, effective treatments for progressive neurodegenerative diseases such as Alzheimer&#39;s disease, Parkinson&#39;s disease, Huntington&#39;s disease and ALS remain elusive, making non-classical drug targets such as nuclear receptors an attractive alternative. A substantial literature in mouse models of disease and several clinical trials have investigated the role of nuclear receptors in various neurodegenerative disorders, most prominently AD. These studies have met with mixed results, yet the majority of studies in mouse models report positive outcomes. The mechanisms by which nuclear receptor agonists affect disease pathology remain unclear. Deciphering the complex signaling underlying nuclear receptor action in neurodegenerative diseases is essential for understanding this variability in preclinical stu...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26939684" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2c43d0869b55faa91b980495d7da4881" rel="nofollow" data-download="{"attachment_id":47203464,"asset_id":26939684,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47203464/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="50957258" href="https://case.academia.edu/RebeccaSkerrett">Rebecca Skerrett</a><script data-card-contents-for-user="50957258" type="text/json">{"id":50957258,"first_name":"Rebecca","last_name":"Skerrett","domain_name":"case","page_name":"RebeccaSkerrett","display_name":"Rebecca Skerrett","profile_url":"https://case.academia.edu/RebeccaSkerrett?f_ri=2214","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-26939684">+1</span><div class="hidden js-additional-users-26939684"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/TMalm">T. 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Despite years of effort, effective treatments for progressive neurodegenerative diseases such as Alzheimer\u0026#39;s disease, Parkinson\u0026#39;s disease, Huntington\u0026#39;s disease and ALS remain elusive, making non-classical drug targets such as nuclear receptors an attractive alternative. A substantial literature in mouse models of disease and several clinical trials have investigated the role of nuclear receptors in various neurodegenerative disorders, most prominently AD. These studies have met with mixed results, yet the majority of studies in mouse models report positive outcomes. The mechanisms by which nuclear receptor agonists affect disease pathology remain unclear. 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Malm","profile_url":"https://independent.academia.edu/TMalm?f_ri=2214","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases?f_ri=2214","nofollow":false},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=2214","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=2214","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=2214"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=2214"},{"id":100501,"name":"Microglia","url":"https://www.academia.edu/Documents/in/Microglia?f_ri=2214"},{"id":244814,"name":"Clinical 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class="summarized">International Conference of Multidisciplinary & Interdisciplinary Bioscience (MIBIO 2022) will provide Biological Sciences Research remains the ubiquitous realm in better human health and well being. Multidisciplinary and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_62345991" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">International Conference of Multidisciplinary & Interdisciplinary Bioscience<br />(MIBIO 2022) will provide Biological Sciences Research remains the ubiquitous realm<br />in better human health and well being. Multidisciplinary and interdisciplinary Bioscience<br />Research has been stressed for explicit scientific advancements. Impact publications for a wider outreach are ascertained. MIBIO 2022 represents the launch-pad forum for<br />researchers, biologists, students, Scientists and Physicians in peer-reviewed podium<br />encompassing Biological Sciences. The conference takes pleasure in inviting your peer<br />Research for a fantabulous realm of rapport in the arena of multidisciplinary and<br />interdisciplinary Life sciences. The area offers discussions with biomedical and<br />environment impact assessors. This allows you to enlighten, enrich and rejuvenate the<br />multitude of oneness in biological sciences</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/62345991" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fc82655aedd17f94338f91a9e17b59f1" rel="nofollow" data-download="{"attachment_id":76888953,"asset_id":62345991,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76888953/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16368816" href="https://independent.academia.edu/IjbbJournal">International Journal on Bioinformatics & Biosciences (IJBB)</a><script data-card-contents-for-user="16368816" type="text/json">{"id":16368816,"first_name":"International Journal on Bioinformatics \u0026 Biosciences","last_name":"(IJBB)","domain_name":"independent","page_name":"IjbbJournal","display_name":"International Journal on Bioinformatics \u0026 Biosciences (IJBB)","profile_url":"https://independent.academia.edu/IjbbJournal?f_ri=2214","photo":"https://0.academia-photos.com/16368816/4447666/66091029/s65_international_journal_on_bioinformatics_biosciences._ijbb_.png"}</script></span></span></li><li class="js-paper-rank-work_62345991 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="62345991"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 62345991, container: ".js-paper-rank-work_62345991", }); 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Multidisciplinary and interdisciplinary Bioscience\nResearch has been stressed for explicit scientific advancements. Impact publications for a wider outreach are ascertained. MIBIO 2022 represents the launch-pad forum for\nresearchers, biologists, students, Scientists and Physicians in peer-reviewed podium\nencompassing Biological Sciences. The conference takes pleasure in inviting your peer\nResearch for a fantabulous realm of rapport in the arena of multidisciplinary and\ninterdisciplinary Life sciences. The area offers discussions with biomedical and\nenvironment impact assessors. 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u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/31960981/Endovanilloid_control_of_pain_modulation_by_the_rostroventromedial_medulla_in_an_animal_model_of_diabetic_neuropathy">Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The involvement of transient receptor vanilloid type-1 (TRPV1) channels in pain modulation by the brain remains understudied. The rostroventromedial medulla (RVM) plays a key role in conveying to the spinal cord pain modulatory influences... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_31960981" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The involvement of transient receptor vanilloid type-1 (TRPV1) channels in pain modulation by the brain remains understudied. The rostroventromedial medulla (RVM) plays a key role in conveying to the spinal cord pain modulatory influences triggered in higher brain centres, with co-existence of inhibitory (antinociceptive) and facilitatory (pronociceptive) effects. In spite of some reports of TRPV1 expression in the RVM, it remains unknown if endovanilloid signalling plays a direct role in local pain modulation. Here we used a model of diabetic neuropathy, the streptozotocin (STZ)-diabetic rat, to study the role of endovanilloid signalling in RVM-mediated pain modulation during chronic pain. Four weeks after diabetes induction, the levels of TRPV1 mRNA and fatty acid amide hydrolase (FAAH), a crucial enzyme for endovanilloid catabolism, in the RVM of STZ-diabetic rats were higher than control. The RVM of STZ-diabetic rats presented decreased levels of several TRPV1 endogenous ligands, namely anandamide (AEA), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). Administration of capsaicin (a TRPV1 agonist) into the RVM decreased nociceptive behavioural responses in the inflammatory phase of the formalin test (phase 2). These findings suggest that diabetic neuropathy induces plastic changes of RVM endovanilloid signaling, indicating that TRPV1 may be a putative target for pain modulation in this chronic pain condition.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31960981" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="41cdadaf08f4f3e82b0eb0d906dba865" rel="nofollow" data-download="{"attachment_id":52235845,"asset_id":31960981,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52235845/download_file?st=MTczMjQxMTIzNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34740020" href="https://kcl.academia.edu/DanielMartins">Daniel Martins</a><script data-card-contents-for-user="34740020" type="text/json">{"id":34740020,"first_name":"Daniel","last_name":"Martins","domain_name":"kcl","page_name":"DanielMartins","display_name":"Daniel Martins","profile_url":"https://kcl.academia.edu/DanielMartins?f_ri=2214","photo":"https://0.academia-photos.com/34740020/10471797/17308731/s65_daniel.martins.jpg"}</script></span></span></li><li class="js-paper-rank-work_31960981 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="31960981"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 31960981, container: ".js-paper-rank-work_31960981", }); 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$(".js-view-count[data-work-id=31960981]").text(description); $(".js-view-count-work_31960981").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_31960981").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="31960981"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2214" href="https://www.academia.edu/Documents/in/Neurobiology_Of_Disease">Neurobiology Of Disease</a>, <script data-card-contents-for-ri="2214" type="text/json">{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4479" href="https://www.academia.edu/Documents/in/Chronic_Pain">Chronic Pain</a>, <script data-card-contents-for-ri="4479" type="text/json">{"id":4479,"name":"Chronic Pain","url":"https://www.academia.edu/Documents/in/Chronic_Pain?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="132028" href="https://www.academia.edu/Documents/in/TRPV1">TRPV1</a>, <script data-card-contents-for-ri="132028" type="text/json">{"id":132028,"name":"TRPV1","url":"https://www.academia.edu/Documents/in/TRPV1?f_ri=2214","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="209529" href="https://www.academia.edu/Documents/in/Diabetic_Neuropathy">Diabetic Neuropathy</a><script data-card-contents-for-ri="209529" type="text/json">{"id":209529,"name":"Diabetic Neuropathy","url":"https://www.academia.edu/Documents/in/Diabetic_Neuropathy?f_ri=2214","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=31960981]'), work: {"id":31960981,"title":"Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy","created_at":"2017-03-21T04:47:54.635-07:00","url":"https://www.academia.edu/31960981/Endovanilloid_control_of_pain_modulation_by_the_rostroventromedial_medulla_in_an_animal_model_of_diabetic_neuropathy?f_ri=2214","dom_id":"work_31960981","summary":"The involvement of transient receptor vanilloid type-1 (TRPV1) channels in pain modulation by the brain remains understudied. The rostroventromedial medulla (RVM) plays a key role in conveying to the spinal cord pain modulatory influences triggered in higher brain centres, with co-existence of inhibitory (antinociceptive) and facilitatory (pronociceptive) effects. In spite of some reports of TRPV1 expression in the RVM, it remains unknown if endovanilloid signalling plays a direct role in local pain modulation. Here we used a model of diabetic neuropathy, the streptozotocin (STZ)-diabetic rat, to study the role of endovanilloid signalling in RVM-mediated pain modulation during chronic pain. Four weeks after diabetes induction, the levels of TRPV1 mRNA and fatty acid amide hydrolase (FAAH), a crucial enzyme for endovanilloid catabolism, in the RVM of STZ-diabetic rats were higher than control. The RVM of STZ-diabetic rats presented decreased levels of several TRPV1 endogenous ligands, namely anandamide (AEA), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). Administration of capsaicin (a TRPV1 agonist) into the RVM decreased nociceptive behavioural responses in the inflammatory phase of the formalin test (phase 2). These findings suggest that diabetic neuropathy induces plastic changes of RVM endovanilloid signaling, indicating that TRPV1 may be a putative target for pain modulation in this chronic pain condition.","downloadable_attachments":[{"id":52235845,"asset_id":31960981,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34740020,"first_name":"Daniel","last_name":"Martins","domain_name":"kcl","page_name":"DanielMartins","display_name":"Daniel Martins","profile_url":"https://kcl.academia.edu/DanielMartins?f_ri=2214","photo":"https://0.academia-photos.com/34740020/10471797/17308731/s65_daniel.martins.jpg"}],"research_interests":[{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease?f_ri=2214","nofollow":false},{"id":4479,"name":"Chronic 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brain during diabetic neuropathy: Uncovering the role of the rostroventromedial medulla</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31960926" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e3f774d8002693d91e382bb3d1e6a722" rel="nofollow" data-download="{"attachment_id":52235809,"asset_id":31960926,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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