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(PDF) Quality of the Haemophilus influenzae Type b (Hib) Antibody Response Induced by Diphtheria-Tetanus-Acellular Pertussis/Hib Combination Vaccines | Jan Poolman - Academia.edu

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{"work":{"id":28870297,"created_at":"2016-10-02T12:43:48.786-07:00","from_world_paper_id":157922609,"updated_at":"2024-11-15T08:02:27.923-08:00","_data":{"grobid_abstract":"It has been repeatedly observed that mixing Haemophilus influenzae type b (Hib) conjugate vaccines with acellular pertussis-containing vaccines (diphtheria-tetanus-acellular pertussis [DTPa]) resulted in a reduced magnitude of the anti-polyriboseribitolphosphate antibody response compared to that obtained when Hib vaccines were administered separately and not mixed. Nevertheless, the quality and functionality of the immune responses have been shown to be the same. With the purpose of investigating the quality of the anti-Hib immune responses that are elicited under different vaccination regimens, we report here four primary and booster-based pediatric clinical trials in which Hib vaccine was either mixed with DTPa or diphtheria-","publication_date":"2007,,","publication_name":"Clinical and Vaccine Immunology","grobid_abstract_attachment_id":"49297294"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Quality of the Haemophilus influenzae Type b (Hib) Antibody Response Induced by Diphtheria-Tetanus-Acellular Pertussis/Hib Combination Vaccines","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [54357892]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; 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Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37298606" href="https://unimedizin-mainz.academia.edu/ClaudiusMeyer">Claudius Meyer</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given&quot;,&quot;attachmentId&quot;:42251428,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="99497823" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants">Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="176086834" href="https://independent.academia.edu/ZeppFred">Fred Zepp</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatrics, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective. Combination vaccines simplify vaccine administration and have the potential to promote compliance and cost-effectiveness by decreasing the number of injections needed to immunize a child. The objective of this study was to assess the safety and reactogenicity of the diphtheria-tetanus toxoid-acellular pertussis-hepatitis B virus-inactivated polio virus (DTPa-HBV-IPV) vaccine when coadministered with different Haemophilus influenzae type B (Hib) vaccines in comparison with separate, commercially available, control vaccines in a 3-dose primary vaccination series. Methods. An open-label, randomized, parallel-group study in 5318 infants who were 8 to 16 weeks of age at enrollment was conducted in 90 centers in Germany. The incidence of adverse events that occurred in infants who received the DTPa-HBV-IPV candidate vaccine coadministered with 1 of 4 different Hib vaccines (given in separate sites; groups 1–4) was compared with the incidence that occurred in infants who receive...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants&quot;,&quot;attachmentId&quot;:100570559,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="28870344" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28870344/Clinical_relevance_of_lower_Hib_response_in_DTPa_based_combination_vaccines">Clinical relevance of lower Hib response in DTPa-based combination vaccines</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="54357892" href="https://independent.academia.edu/JanPoolman">Jan Poolman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2001</p><p class="ds-related-work--abstract ds2-5-body-sm">Combination vaccines are essential to enable administration of all the required antigens in routine infant immunisation schedules at any single visit. Some combinations of diphtheria-tetanus-acellular pertussis (DTPa) with Haemophilus influenzae type b (Hib) conjugate vaccines have been shown to result in lower Hib titres than when Hib is administered separately. While confirming that a primary series with a DTPa-HBV-IPV/Hib combination gives lower antibody levels than separate Hib conjugates, we show that the nature (isotype and IgG subclasses) and function (avidity and opsonic activity) of the antibodies are the same, and immunologic memory is induced. It is likely therefore that the DTPa-HBV-IPV/Hib combination will be efficacious against Hib disease.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Clinical relevance of lower Hib response in DTPa-based combination vaccines&quot;,&quot;attachmentId&quot;:49297327,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/28870344/Clinical_relevance_of_lower_Hib_response_in_DTPa_based_combination_vaccines&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/28870344/Clinical_relevance_of_lower_Hib_response_in_DTPa_based_combination_vaccines"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="63167849" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63167849/Suppression_and_Modulation_of_Cellular_and_Humoral_Immune_Responses_to_Haemophilus_influenzae_Type_B_Hib_Conjugate_Vaccine_in_Hib_Diphtheria_Tetanus_Toxoids_Acellular_Pertussis_Combination_Vaccines_A_Study_in_a_Rat_Model">Suppression and Modulation of Cellular and Humoral Immune Responses to Haemophilus influenzae Type B (Hib) Conjugate Vaccine in Hib-Diphtheria-Tetanus Toxoids-Acellular Pertussis Combination Vaccines: A Study in a Rat Model</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="128181599" href="https://independent.academia.edu/SamPeacock2">Sam Peacock</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Infectious Diseases, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Suppression and Modulation of Cellular and Humoral Immune Responses to Haemophilus influenzae Type B (Hib) Conjugate Vaccine in Hib-Diphtheria-Tetanus Toxoids-Acellular Pertussis Combination Vaccines: A Study in a Rat Model&quot;,&quot;attachmentId&quot;:75680940,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/63167849/Suppression_and_Modulation_of_Cellular_and_Humoral_Immune_Responses_to_Haemophilus_influenzae_Type_B_Hib_Conjugate_Vaccine_in_Hib_Diphtheria_Tetanus_Toxoids_Acellular_Pertussis_Combination_Vaccines_A_Study_in_a_Rat_Model&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63167849/Suppression_and_Modulation_of_Cellular_and_Humoral_Immune_Responses_to_Haemophilus_influenzae_Type_B_Hib_Conjugate_Vaccine_in_Hib_Diphtheria_Tetanus_Toxoids_Acellular_Pertussis_Combination_Vaccines_A_Study_in_a_Rat_Model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="4278383" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections">Primary vaccination of infants with diphtheria-tetanus-acellular pertussis–hepatitis B virus– inactivated polio virus and Haemophilus influenzae type b vaccines given as either separate or mixed injections</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5193659" href="https://independent.academia.edu/OrtizEsteban">Esteban Ortiz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Pediatrics, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Primary vaccination of infants with diphtheria-tetanus-acellular pertussis–hepatitis B virus– inactivated polio virus and Haemophilus influenzae type b vaccines given as either separate or mixed injections&quot;,&quot;attachmentId&quot;:49963493,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="92826712" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine">Reactogenicity and Immunogenicity Profiles of a Novel Pentavalent Diphtheria-Tetanus???Whole Cell Pertussis???Hepatitis B and Haemophilus Influenzae Type B Vaccine</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="249836346" href="https://independent.academia.edu/TheinAungMyat">Aung Myat Thein</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Pediatric Infectious Disease Journal, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Reactogenicity and Immunogenicity Profiles of a Novel Pentavalent Diphtheria-Tetanus???Whole Cell Pertussis???Hepatitis B and Haemophilus Influenzae Type B Vaccine&quot;,&quot;attachmentId&quot;:95732621,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="89762773" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/89762773/Comparison_of_separate_and_mixed_administration_of_DTPw_HBV_and_Hib_vaccines_Immunogenicity_and_reactogenicity_profiles">Comparison of separate and mixed administration of DTPw-HBV and Hib vaccines: Immunogenicity and reactogenicity profiles</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="243267001" href="https://independent.academia.edu/KhinKhinWin3">Khin Khin Win</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Infectious Diseases, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Comparison of separate and mixed administration of DTPw-HBV and Hib vaccines: Immunogenicity and reactogenicity profiles&quot;,&quot;attachmentId&quot;:93514569,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/89762773/Comparison_of_separate_and_mixed_administration_of_DTPw_HBV_and_Hib_vaccines_Immunogenicity_and_reactogenicity_profiles&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/89762773/Comparison_of_separate_and_mixed_administration_of_DTPw_HBV_and_Hib_vaccines_Immunogenicity_and_reactogenicity_profiles"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="27615805" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic">Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37075888" href="https://independent.academia.edu/KarinHardt">Karin Hardt</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Infectious Diseases, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic&quot;,&quot;attachmentId&quot;:47880484,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="15536449" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age">Reactogenicity of DTPa-HBV/Hib vaccine administered as a single injection vs DTPa-HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34691855" href="https://independent.academia.edu/Jos%C3%A9Garciasicilia">José Garcia-sicilia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2001</p><p class="ds-related-work--abstract ds2-5-body-sm">An open, randomised, multicentre trial was performed to assess the reactogenicity and safety profile of the administration of a candidate Haemophilus influenzae type b (Hib) conjugate vaccine with a quadrivalent diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine as a single injection (Group 1) versus the simultaneous administration of the latter vaccine (DTPa-HBV) and an available Hib conjugate vaccine (Group 2) in opposite thighs, as a primary vaccination course to healthy infants at 2, 4 and 6 months of age. Eight hundred and eighty five infants (9.3+/-1.4 weeks old) were randomly allocated to Group 1 (n=665) and Group 2 (n=221). Oral polio vaccine was given concomitantly to all subjects. Blood samples (pre-vaccination and 1 month after the third dose) were obtained from a subset of infants (Group 1, 73; Group 2, 22) for serological determinations. Local and general symptoms were recorded by parents on diary cards. 2614 diary cards (Group 1, 1966; Group 2, 648) ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Reactogenicity of DTPa-HBV/Hib vaccine administered as a single injection vs DTPa-HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age&quot;,&quot;attachmentId&quot;:43111726,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;continue-reading-button--sticky-ctas&quot;,&quot;attachmentId&quot;:49297294,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;workUrl&quot;:null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;download-pdf-button--sticky-ctas&quot;,&quot;attachmentId&quot;:49297294,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;workUrl&quot;:null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_49297294" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="4578781" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4578781/Pattern_of_functional_antibody_activity_against_Haemophilus_influenzae_type_b_Hib_in_infants_immunized_with_diphtheria_tetanus_pertussis_Hib_Brazilian_combination_vaccine">Pattern of functional antibody activity against Haemophilus influenzae type b (Hib) in infants immunized with diphtheria-tetanus-pertussis/Hib Brazilian combination vaccine</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="15859662" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity">A combined liquid Hib (PRP-OMP), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and reactogenicity</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35037977" href="https://usfca.academia.edu/MaryDarcy">Mary Darcy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><div 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js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="13904521" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13904521/Immunogenicity_and_Reactogenicity_following_Primary_Immunisation_with_a_Combined_DTaP_HBV_Vaccine_and_a_Haemophilus_influenzae_Type_B_Vaccine_Administered_by_Separate_or_Mixed_Injection">Immunogenicity and Reactogenicity following Primary Immunisation with a Combined DTaP-HBV Vaccine and a??Haemophilus influenzae Type B Vaccine Administered by Separate or Mixed Injection</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32975976" href="https://ulg.academia.edu/KarinHardt">Karin Hardt</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Drug Investigation, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Immunogenicity and Reactogenicity following Primary Immunisation with a Combined DTaP-HBV Vaccine and a??Haemophilus influenzae Type B Vaccine Administered by Separate or Mixed 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="113807853" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/113807853/Safety_and_reactogenicity_of_DTPa_HBV_IPV_Hib_and_DTPa_IPV_I_Hib_vaccines_in_a_post_marketing_surveillance_setting">Safety and reactogenicity of DTPa-HBV-IPV/Hib and DTPa-IPV/I-Hib vaccines in a post-marketing surveillance setting</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40792864" href="https://independent.academia.edu/KongPhua">Kong Phua</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Southeast Asian journal of tropical medicine and public health, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="15859663" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15859663/A_combined_liquid_Hib_PRP_OMPC_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_controlled_studies_of_immunogenicity_and_reactogenicity">A combined liquid Hib (PRP-OMPC), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: controlled studies of immunogenicity and reactogenicity</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35037977" href="https://usfca.academia.edu/MaryDarcy">Mary Darcy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;A combined liquid Hib (PRP-OMPC), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: controlled studies of immunogenicity and reactogenicity&quot;,&quot;attachmentId&quot;:42850597,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/15859663/A_combined_liquid_Hib_PRP_OMPC_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_controlled_studies_of_immunogenicity_and_reactogenicity&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2293675" href="https://ankara.academia.edu/BetulUlukol">Betul Ulukol</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life&quot;,&quot;attachmentId&quot;:50600022,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="32135519" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/32135519/Safety_and_immunogenicity_of_a_diphtheria_tetanus_acellular_pertussis_and_Haemophilus_influenzae_Type_b_combination_vaccine_compared_with_separate_administration_of_licensed_equivalent_vaccines_in_Chinese_infants_and_toddlers_for_primary_and_booster_immunization">Safety and immunogenicity of a diphtheria, tetanus, acellular pertussis and Haemophilus influenzae Type b combination vaccine compared with separate administration of licensed equivalent vaccines in Chinese infants and toddlers for primary and booster immunization</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="62301814" href="https://independent.academia.edu/QiangYe4">Qiang Ye</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/32135519/Safety_and_immunogenicity_of_a_diphtheria_tetanus_acellular_pertussis_and_Haemophilus_influenzae_Type_b_combination_vaccine_compared_with_separate_administration_of_licensed_equivalent_vaccines_in_Chinese_infants_and_toddlers_for_primary_and_booster_immunization"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="62049503" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules">Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31850906" href="https://unito.academia.edu/CarlaZotti">Carla Zotti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="48819486" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/48819486/Immunogenicity_and_safety_of_3_dose_primary_vaccination_with_combined_DTPa_HBV_IPV_Hib_in_Indian_infants">Immunogenicity and safety of 3-dose primary vaccination with combined DTPa-HBV-IPV/Hib in Indian infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41198478" href="https://independent.academia.edu/ShalakaAgarkhedkar">Shalaka Agarkhedkar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines &amp; Immunotherapeutics, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="73781061" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73781061/Immunogenicity_and_Reactogenicity_of_DTPa_IPV_Hib_Vaccine_Co_administered_With_Hepatitis_B_Vaccine_for_Primary_and_Booster_Vaccination_of_Taiwanese_Infants">Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="217595099" href="https://independent.academia.edu/YuChiaHsieh">Yu Chia Hsieh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of the Formosan Medical Association, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants&quot;,&quot;attachmentId&quot;:82168690,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/73781061/Immunogenicity_and_Reactogenicity_of_DTPa_IPV_Hib_Vaccine_Co_administered_With_Hepatitis_B_Vaccine_for_Primary_and_Booster_Vaccination_of_Taiwanese_Infants&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/73781061/Immunogenicity_and_Reactogenicity_of_DTPa_IPV_Hib_Vaccine_Co_administered_With_Hepatitis_B_Vaccine_for_Primary_and_Booster_Vaccination_of_Taiwanese_Infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="29154874" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course">Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="54905929" href="https://independent.academia.edu/ValterSundh">Valter Sundh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of the Formosan Medical Association, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course&quot;,&quot;attachmentId&quot;:49599593,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="4119838" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4119838/Associated_or_combined_vaccination_of_Brazilian_infants_with_a_conjugate_Haemophilus_influenzae_type_b_Hib_vaccine_a_diphtheria_tetanus_whole_cell_pertussis_vaccine_and_IPV_or_OPV_elicits_protective_levels_of_antibodies_against_Hib">Associated or combined vaccination of Brazilian infants with a conjugate Haemophilus influenzae type b (Hib) vaccine, a diphtheria–tetanus–whole-cell pertussis vaccine and IPV or OPV elicits protective levels of antibodies against Hib</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4974027" href="https://ufabc.academia.edu/EduardoCrevelariodeCarvalho">Eduardo E Crevelario de Carvalho</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Associated or combined vaccination of Brazilian infants with a conjugate Haemophilus influenzae type b (Hib) vaccine, a diphtheria–tetanus–whole-cell pertussis vaccine and IPV or OPV elicits protective levels of antibodies against 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href="https://www.academia.edu/18580941/Interaction_of_Haemophilus_influenzae_type_b_conjugate_vaccines_with_diphtheria_tetanus_pertussis_vaccine_in_control_tests"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="11441050" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants">Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27850479" href="https://independent.academia.edu/JuanLopez251">Juan Lopez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants&quot;,&quot;attachmentId&quot;:46706768,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" 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ORTIZ</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Infectious Diseases, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;A fully liquid diphtheria–tetanus–five component acellular pertussis–inactivated poliomyelitis–Haemophilus influenzae type b conjugate vaccine: immunogenicity and safety of primary vaccination in Taiwanese infants&quot;,&quot;attachmentId&quot;:118233648,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/123908120/A_fully_liquid_diphtheria_tetanus_five_component_acellular_pertussis_inactivated_poliomyelitis_Haemophilus_influenzae_type_b_conjugate_vaccine_immunogenicity_and_safety_of_primary_vaccination_in_Taiwanese_infants&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/123908120/A_fully_liquid_diphtheria_tetanus_five_component_acellular_pertussis_inactivated_poliomyelitis_Haemophilus_influenzae_type_b_conjugate_vaccine_immunogenicity_and_safety_of_primary_vaccination_in_Taiwanese_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="16" data-entity-id="15658011" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15658011/Adverse_effects_and_sero_responses_to_an_acellular_pertussis_diphtheria_tetanus_vaccine_when_combined_with_Haemophilus_influenzae_type_b_vaccine_in_an_accelerated_schedule">Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34842742" href="https://independent.academia.edu/CharlesThornton3">Charles Thornton</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Pediatrics, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Adverse effects and sero-responses to an acellular 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