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type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"An open, randomised, multicentre trial was performed to compare the reactogenicity and safety profile of the administration of a hexavalent diphtheria-tetanus-acellular pertussis–hepatitis B–inactivated polio (DTPa–HBV–IPV) vaccine administered in one injection mixed with Haemophilus influenzae type b (Hib) conjugate vaccine (Group 1) with that of a pentavalent DTPa–IPV vaccine mixed with a Hib vaccine (DTPa–IPV/Hib), simultaneously administered with HBV (Group 2)","author":[{"@context":"https://schema.org","@type":"Person","name":"Josep Marés"},{"@context":"https://schema.org","@type":"Person","name":"Eugenio de Frutos"}],"contributor":[{"@context":"https://schema.org","@type":"Person","name":"Eugenio de Frutos"}],"dateCreated":"2015-10-14","dateModified":"2023-12-17","datePublished":"2003-01-01","headline":"Comparison of the reactogenicity and immunogenicity of a combined diphtheria, 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influenzae type b (Hib) conjugate vaccine and administered as a single injection, with the DTPa–IPV/Hib and...</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="26641596" href="https://independent.academia.edu/EugeniodeFrutos"><img alt="Profile image of Eugenio de Frutos" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/26641596/7416203/8336011/s65_eugenio.de_frutos.jpg" />Eugenio de Frutos</a><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="36236693" href="https://independent.academia.edu/JosepMar%C3%A9s"><img alt="Profile image of Josep Marés" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Josep Marés</a></div><p class="ds-work-card--detail ds2-5-body-sm">2003, Vaccine</p><div class="ds-work-card--button-container"><button class="ds2-5-button 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data-landing_url="https://www.academia.edu/16795810/Comparison_of_the_reactogenicity_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_DTPa_HBV_IPV_vaccine_mixed_with_the_Haemophilus_influenzae_type_b_Hib_conjugate_vaccine_and_administered_as_a_single_injection_with_the_DTPa_IPV_Hib_and_" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="99497823" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants">Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="176086834" href="https://independent.academia.edu/ZeppFred">Fred Zepp</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatrics, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective. Combination vaccines simplify vaccine administration and have the potential to promote compliance and cost-effectiveness by decreasing the number of injections needed to immunize a child. The objective of this study was to assess the safety and reactogenicity of the diphtheria-tetanus toxoid-acellular pertussis-hepatitis B virus-inactivated polio virus (DTPa-HBV-IPV) vaccine when coadministered with different Haemophilus influenzae type B (Hib) vaccines in comparison with separate, commercially available, control vaccines in a 3-dose primary vaccination series. Methods. An open-label, randomized, parallel-group study in 5318 infants who were 8 to 16 weeks of age at enrollment was conducted in 90 centers in Germany. 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href="https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given">Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37298606" href="https://unimedizin-mainz.academia.edu/ClaudiusMeyer">Claudius Meyer</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and 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href="https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="2495889" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life">Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2293675" href="https://ankara.academia.edu/BetulUlukol">Betul Ulukol</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1999</p><p class="ds-related-work--abstract ds2-5-body-sm">This study was designed to assess the immunogenicity of a vaccine combining diphtheria and tetanus toxoids, acellular pertussis vaccine, and inactivated poliovirus vaccine reconstituting Haemophilus influenzae type b polysaccharide conjugated to tetanus protein (DTaP-IPV//PRP-T; Pasteur Mérieux Connaught, Lyon, France) administered simultaneously in association with hepatitis B vaccine (RECOMBIVAX ™ Merck, Sharp & Dohme, West Point, PA, USA) for the primary immunization of infants. The vaccines were administered at two, three and four months of age. One hundred and sixty-two healthy infants, aged 8–10 weeks, were enrolled in the study. Blood samples were taken before the first dose and 4 weeks after the third dose. The infants were observed for 15 minutes after vaccination for any immediate reaction. Adverse events requiring a medical consultation were recorded by the parents in a diary over the 7 days following vaccination. Four weeks after the third immunization, the percentages of infants fulfilling seroconversion criteria were 98.9% for pertussis toxin, 95.9% for filamentous haemagglutinin, 100.0% for tetanus, 100.0% for diphtheria, 99.3% for poliovirus type 1, 100.0% for both poliovirus types 2 and 3, 98.0% for Haemophilus influenzae type b, and 100% for hepatitis B surface antigen. No vaccine-related serious adverse event was reported. The simultaneous administration of DTaP-IPV//PRP-T and hepatitis B vaccines at two, three and four months of age yielded clinically satisfactory immune responses to all antigens compared with historical controls and gave a good safety profile.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life","attachmentId":50600022,"attachmentType":"pdf","work_url":"https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="16626614" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16626614/Safety_reactogenicity_and_immunogenicity_of_a_combined_hexavalent_tetanus_diphtheria_acellular_pertussis_hepatitis_B_inactivated_poliovirus_vaccine_and_Haemophilus_influenzae_type_b_conjugate_vaccine_for_primary_immunization_of_infants">Safety, reactogenicity and immunogenicity of a combined hexavalent tetanus, diphtheria, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate vaccine, for primary immunization of infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35974695" href="https://unibas.academia.edu/UlrichHeininger">Ulrich Heininger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2004</p><p class="ds-related-work--abstract ds2-5-body-sm">Safety, reactogenicity and immunogenicity of GSK Biologicals&amp;#39; hexavalent DTPa-HBV-IPV/Hib vaccine (Infanrix)hexa) was assessed when used for primary vaccination at 3, 4 and 5 months of age (N = 2163), compared to the separate administration of DTPa-IPV/Hib and HBV vaccines (N = 720). A similar safety and reactogenicity profile was demonstrated for both vaccine regimens, as well as a good immune response for all antigen components. By offering protection against six diseases in a series of single injections, the hexavalent DTPa-HBV-IPV/Hib vaccine was shown to be a safe, well tolerated and immunogenic alternative to primary immunization with licensed separately administered vaccines.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety, reactogenicity and immunogenicity of a combined hexavalent tetanus, diphtheria, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate vaccine, for primary immunization of infants","attachmentId":42424809,"attachmentType":"pdf","work_url":"https://www.academia.edu/16626614/Safety_reactogenicity_and_immunogenicity_of_a_combined_hexavalent_tetanus_diphtheria_acellular_pertussis_hepatitis_B_inactivated_poliovirus_vaccine_and_Haemophilus_influenzae_type_b_conjugate_vaccine_for_primary_immunization_of_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16626614/Safety_reactogenicity_and_immunogenicity_of_a_combined_hexavalent_tetanus_diphtheria_acellular_pertussis_hepatitis_B_inactivated_poliovirus_vaccine_and_Haemophilus_influenzae_type_b_conjugate_vaccine_for_primary_immunization_of_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="15859663" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15859663/A_combined_liquid_Hib_PRP_OMPC_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_controlled_studies_of_immunogenicity_and_reactogenicity">A combined liquid Hib (PRP-OMPC), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: controlled studies of immunogenicity and reactogenicity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35037977" href="https://usfca.academia.edu/MaryDarcy">Mary Darcy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A combined liquid Hib (PRP-OMPC), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: controlled studies of immunogenicity and reactogenicity","attachmentId":42850597,"attachmentType":"pdf","work_url":"https://www.academia.edu/15859663/A_combined_liquid_Hib_PRP_OMPC_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_controlled_studies_of_immunogenicity_and_reactogenicity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15859663/A_combined_liquid_Hib_PRP_OMPC_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_controlled_studies_of_immunogenicity_and_reactogenicity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="92826712" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine">Reactogenicity and Immunogenicity Profiles of a Novel Pentavalent Diphtheria-Tetanus???Whole Cell Pertussis???Hepatitis B and Haemophilus Influenzae Type B Vaccine</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="249836346" href="https://independent.academia.edu/TheinAungMyat">Aung Myat Thein</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Pediatric Infectious Disease Journal, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity and Immunogenicity Profiles of a Novel Pentavalent Diphtheria-Tetanus???Whole Cell Pertussis???Hepatitis B and Haemophilus Influenzae Type B Vaccine","attachmentId":95732621,"attachmentType":"pdf","work_url":"https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="29154874" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course">Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="54905929" href="https://independent.academia.edu/ValterSundh">Valter Sundh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of the Formosan Medical Association, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course","attachmentId":49599593,"attachmentType":"pdf","work_url":"https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="15536449" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age">Reactogenicity of DTPa-HBV/Hib vaccine administered as a single injection vs DTPa-HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34691855" href="https://independent.academia.edu/Jos%C3%A9Garciasicilia">José Garcia-sicilia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2001</p><p class="ds-related-work--abstract ds2-5-body-sm">An open, randomised, multicentre trial was performed to assess the reactogenicity and safety profile of the administration of a candidate Haemophilus influenzae type b (Hib) conjugate vaccine with a quadrivalent diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine as a single injection (Group 1) versus the simultaneous administration of the latter vaccine (DTPa-HBV) and an available Hib conjugate vaccine (Group 2) in opposite thighs, as a primary vaccination course to healthy infants at 2, 4 and 6 months of age. Eight hundred and eighty five infants (9.3+/-1.4 weeks old) were randomly allocated to Group 1 (n=665) and Group 2 (n=221). Oral polio vaccine was given concomitantly to all subjects. Blood samples (pre-vaccination and 1 month after the third dose) were obtained from a subset of infants (Group 1, 73; Group 2, 22) for serological determinations. Local and general symptoms were recorded by parents on diary cards. 2614 diary cards (Group 1, 1966; Group 2, 648) ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity of DTPa-HBV/Hib vaccine administered as a single injection vs DTPa-HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age","attachmentId":43111726,"attachmentType":"pdf","work_url":"https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="15859662" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity">A combined liquid Hib (PRP-OMP), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and reactogenicity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35037977" href="https://usfca.academia.edu/MaryDarcy">Mary Darcy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A combined liquid Hib (PRP-OMP), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and reactogenicity","attachmentId":42850599,"attachmentType":"pdf","work_url":"https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":39187356,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":39187356,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_39187356" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="27615805" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic">Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37075888" href="https://independent.academia.edu/KarinHardt">Karin Hardt</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Infectious Diseases, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic","attachmentId":47880484,"attachmentType":"pdf","work_url":"https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="113807853" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/113807853/Safety_and_reactogenicity_of_DTPa_HBV_IPV_Hib_and_DTPa_IPV_I_Hib_vaccines_in_a_post_marketing_surveillance_setting">Safety and reactogenicity of DTPa-HBV-IPV/Hib and DTPa-IPV/I-Hib vaccines in a post-marketing surveillance setting</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40792864" href="https://independent.academia.edu/KongPhua">Kong Phua</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Southeast Asian journal of tropical medicine and public health, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants","attachmentId":82168690,"attachmentType":"pdf","work_url":"https://www.academia.edu/73781061/Immunogenicity_and_Reactogenicity_of_DTPa_IPV_Hib_Vaccine_Co_administered_With_Hepatitis_B_Vaccine_for_Primary_and_Booster_Vaccination_of_Taiwanese_Infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31850906" href="https://unito.academia.edu/CarlaZotti">Carla Zotti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules","attachmentId":74917132,"attachmentType":"pdf","work_url":"https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" 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href="https://www.academia.edu/16980685/Immunogenicity_and_safety_of_a_DTaP_IPV_PRP_approximately_T_combination_vaccine_given_with_hepatitis_B_vaccine_a_randomized_open_label_trial">Immunogenicity and safety of a DTaP-IPV//PRP approximately T combination vaccine given with hepatitis B vaccine: a randomized open-label trial</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36500531" href="https://independent.academia.edu/MariaCapeding">Maria Capeding</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Bulletin of the World Health Organization, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and safety of a DTaP-IPV//PRP approximately T combination vaccine given with hepatitis B vaccine: a randomized open-label 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data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and safety of 3-dose primary vaccination with combined DTPa-HBV-IPV/Hib in Indian infants","attachmentId":67244270,"attachmentType":"pdf","work_url":"https://www.academia.edu/48819486/Immunogenicity_and_safety_of_3_dose_primary_vaccination_with_combined_DTPa_HBV_IPV_Hib_in_Indian_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/48819486/Immunogenicity_and_safety_of_3_dose_primary_vaccination_with_combined_DTPa_HBV_IPV_Hib_in_Indian_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div 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class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A randomized, dose-ranging assessment of the immunogenicity and safety of a booster dose of a combined diphtheria-tetanus-whole cell pertussis-hepatitis B-inactivated poliovirus- Hemophilus influenzae type b (DTPw-HBV-IPV/Hib) vaccine vs. co-administration of DTPw-HBV/Hib and IPV vaccines in 12 t...","attachmentId":67057517,"attachmentType":"pdf","work_url":"https://www.academia.edu/48454830/A_randomized_dose_ranging_assessment_of_the_immunogenicity_and_safety_of_a_booster_dose_of_a_combined_diphtheria_tetanus_whole_cell_pertussis_hepatitis_B_inactivated_poliovirus_Hemophilus_influenzae_type_b_DTPw_HBV_IPV_Hib_vaccine_vs_co_administration_of_DTPw_HBV_Hib_and_IPV_vaccines_in_12_t_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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href="https://www.academia.edu/14115018/Safety_and_immunogenicity_of_a_diphtheria_tetanus_and_acellular_pertussis_inactivated_poliovirus_vaccine_Haemophilus_influenzae_type_B_combination_vaccine_administered_to_Taiwanese_infants_at_2_4_and_6_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="63167849" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63167849/Suppression_and_Modulation_of_Cellular_and_Humoral_Immune_Responses_to_Haemophilus_influenzae_Type_B_Hib_Conjugate_Vaccine_in_Hib_Diphtheria_Tetanus_Toxoids_Acellular_Pertussis_Combination_Vaccines_A_Study_in_a_Rat_Model">Suppression and Modulation of Cellular and Humoral Immune 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="15" data-entity-id="4119838" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4119838/Associated_or_combined_vaccination_of_Brazilian_infants_with_a_conjugate_Haemophilus_influenzae_type_b_Hib_vaccine_a_diphtheria_tetanus_whole_cell_pertussis_vaccine_and_IPV_or_OPV_elicits_protective_levels_of_antibodies_against_Hib">Associated or combined vaccination of Brazilian infants with a conjugate Haemophilus influenzae type b (Hib) vaccine, a diphtheria–tetanus–whole-cell pertussis vaccine and IPV or OPV elicits protective levels of antibodies against Hib</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4974027" href="https://ufabc.academia.edu/EduardoCrevelariodeCarvalho">Eduardo E Crevelario de Carvalho</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Associated or combined vaccination of Brazilian infants with a conjugate Haemophilus influenzae type b (Hib) vaccine, a diphtheria–tetanus–whole-cell pertussis vaccine and IPV or OPV elicits protective levels of antibodies against Hib","attachmentId":50023259,"attachmentType":"pdf","work_url":"https://www.academia.edu/4119838/Associated_or_combined_vaccination_of_Brazilian_infants_with_a_conjugate_Haemophilus_influenzae_type_b_Hib_vaccine_a_diphtheria_tetanus_whole_cell_pertussis_vaccine_and_IPV_or_OPV_elicits_protective_levels_of_antibodies_against_Hib","alternativeTracking":true}"><span class="material-symbols-outlined" 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href="https://www.academia.edu/18549004/Safety_and_immunogenicity_of_a_combined_five_component_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_b_conjugate_vaccine_administered_to_infants_at_two_four_and_six_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="17" data-entity-id="13904521" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13904521/Immunogenicity_and_Reactogenicity_following_Primary_Immunisation_with_a_Combined_DTaP_HBV_Vaccine_and_a_Haemophilus_influenzae_Type_B_Vaccine_Administered_by_Separate_or_Mixed_Injection">Immunogenicity and Reactogenicity following Primary Immunisation with a Combined DTaP-HBV Vaccine and a??Haemophilus 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