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class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Mary Darcy</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://usfca.academia.edu/">University of San Francisco</a>, <a class="u-tcGrayDarker" href="https://usfca.academia.edu/Departments/Psychology/Documents">Psychology</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Mary" data-follow-user-id="35037977" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" 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data-dom-id="Pill-react-component-f3068d15-1737-49f3-8f32-98f38c2067c2"></div> <div id="Pill-react-component-f3068d15-1737-49f3-8f32-98f38c2067c2"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Mary Darcy</h3></div><div class="js-work-strip profile--work_container" data-work-id="15859671"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15859671/Risk_scoring_systems_for_predicting_preterm_birth_with_the_aim_of_reducing_associated_adverse_outcomes"><img alt="Research paper thumbnail of Risk scoring systems for predicting preterm birth with the aim of reducing associated adverse outcomes" class="work-thumbnail" src="https://attachments.academia-assets.com/42850592/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15859671/Risk_scoring_systems_for_predicting_preterm_birth_with_the_aim_of_reducing_associated_adverse_outcomes">Risk scoring systems for predicting preterm birth with the aim of reducing associated adverse outcomes</a></div><div class="wp-workCard_item"><span>Reviews</span><span>, 1996</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4b162efee437a3c94e696c3ddbdac642" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42850592,"asset_id":15859671,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42850592/download_file?st=MTczMjQzMDExOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15859671"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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class="js-work-strip profile--work_container" data-work-id="15859666"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15859666/Having_a_baby_in_Victoria_1989_2000_continuity_and_change_in_the_decade_following_the_Victorian_Ministerial_Review_of_Birthing_Services"><img alt="Research paper thumbnail of Having a baby in Victoria 1989-2000: continuity and change in the decade following the Victorian Ministerial Review of Birthing Services" class="work-thumbnail" src="https://attachments.academia-assets.com/42850593/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" 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href="https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity"><img alt="Research paper thumbnail of A combined liquid Hib (PRP-OMP), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and reactogenicity" class="work-thumbnail" src="https://attachments.academia-assets.com/42850599/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity">A combined liquid Hib (PRP-OMP), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and reactogenicity</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a8ecf78a2a00a2561722107937cb800" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42850599,"asset_id":15859662,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42850599/download_file?st=MTczMjQzMDExOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15859662"><a class="js-profile-work-strip-edit-button" 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$('.js-work-strip[data-work-id=15859662]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15859662,"title":"A combined liquid Hib (PRP-OMP), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and reactogenicity","translated_title":"","metadata":{"grobid_abstract":"porates a diphtheria, tetanus and whole-cell pertussis vaccine with Hib (PRPOMP) and hepatitis B vaccines. Forty-jive infants received three doses of the pentavalent vaccination at 2, 4, and 6 months of age, and then a fourth dose at 18 months of age. Subjects were bled prior to each vaccination, and a month after the third and fourth vaccinations. A 7-day diary card was used to record subject temperatures and other systemic and local clinical signs after each vaccination. After the third dose, 98% of subjects had anti-PRP titres above 1 pg ml-' (95%ci 88%, 100Y0). Following boosting, the geometric mean titre (GMT) rose a mean 27-fold (95%ci 19-fold, 38-fold) to 33 /g ml-', and all suqjects' titres (lower bound of 95%ci 92%) exceeded 1 pg ml-'. For hepatitis B antibodji there was a GMT of 100 mIU ml-' after the third dose, and 86% of infants (95%ci 73%, 9.5%) had antibody levels 210 mIU ml-'. After the fourth dose, there was a mean 77-fold boost (95%ci 48-fold, 130-fold) to a GMT of 860 mIU ml-' and 95% (95%ci 84%, 99%) of subjects had titres 210 mIU ml-. Diphtheria, tetanus, and pertussis antibody levels were all at acceptable levels after the first three doses and again after the fourth vaccination. The pentavalent vaccine was well tolerated at all administration times, and had a minor reactogenicity profile similar to DTPw alone 17s reported in previous studies. This study has provided preliminary evidence for both the safety and immunogenic@ of the pentavalent vaccine given as a course at 2, 4, 6 and 18 months. 0 1998 Elsevier Science Ltd. All rights reserved Keywords: DTF'w-Hib-hepatitis B; vaccine: immunogenicity routinely administered in more than 20 countries, and Global control of diphtheria, tetanus, pertussis, hepatitis B and Hib disease are realizable objectives with modern vaccine development. 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are","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Vaccine","grobid_abstract_attachment_id":42850599},"translated_abstract":null,"internal_url":"https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity","translated_internal_url":"","created_at":"2015-09-18T10:55:26.202-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":35037977,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":42850599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42850599/thumbnails/1.jpg","file_name":"s0264-410x_2898_2900074-7.pdf20160219-3022-1u96mcn","download_url":"https://www.academia.edu/attachments/42850599/download_file?st=MTczMjQzMDExOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_combined_liquid_Hib_PRP_OMP_hepatitis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42850599/s0264-410x_2898_2900074-7-libre.pdf20160219-3022-1u96mcn?1455921395=\u0026response-content-disposition=attachment%3B+filename%3DA_combined_liquid_Hib_PRP_OMP_hepatitis.pdf\u0026Expires=1732433718\u0026Signature=Wz7rE1yQhhdOMRB0k2f8yWY77I7Ufxc3AY1zclw9dGx4fFGr1l-xA4FVmQdRC~qtBgGbDlDTv-sKOLbCouoSBtBl71UmbdOZUzNvHNUlc0tnAAYNysJ3A4s4BdYuKTHPtvqHuZbvCXUolyrjAvSbgthOol8oYjJ0uITcLLpUxcRmwzTVrtVR4jWRjZvyhAnvDzq1vzgjCGHVlpREC1lUuujfJOTP8DuBkiSy5elllwo0lXGM-T5RYqJfHW7mL0HTTKPILLtEFUXqfJpIyZFn1HjejWmS6l9YQ3SV3GnWAqfxZ3FBWTtCLmQS2~ISOKh3s52uJu5fRH-cUnErkqdzkA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":35037977,"first_name":"Mary","middle_initials":null,"last_name":"Darcy","page_name":"MaryDarcy","domain_name":"usfca","created_at":"2015-09-18T10:43:32.532-07:00","display_name":"Mary 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B Vaccine at Birth Followed by Pentavalent DTPw/PRP-OMP/Hepatitis B Vaccine at 2, 4, and 6 Months. ♦ 884" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15859660/Immunogenicity_and_Reactogenicity_of_2_5%CE%BCg_or_5%CE%BCg_Monovalent_Hepatitis_B_Vaccine_at_Birth_Followed_by_Pentavalent_DTPw_PRP_OMP_Hepatitis_B_Vaccine_at_2_4_and_6_Months_884">Immunogenicity and Reactogenicity of 2.5μg or 5μg Monovalent Hepatitis B Vaccine at Birth Followed by Pentavalent DTPw/PRP-OMP/Hepatitis B Vaccine at 2, 4, and 6 Months. ♦ 884</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and reactogenicity</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a8ecf78a2a00a2561722107937cb800" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42850599,"asset_id":15859662,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42850599/download_file?st=MTczMjQzMDExOCw4LjIyMi4yMDguMTQ2&st=MTczMjQzMDExOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15859662"><a 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Forty-jive infants received three doses of the pentavalent vaccination at 2, 4, and 6 months of age, and then a fourth dose at 18 months of age. Subjects were bled prior to each vaccination, and a month after the third and fourth vaccinations. A 7-day diary card was used to record subject temperatures and other systemic and local clinical signs after each vaccination. After the third dose, 98% of subjects had anti-PRP titres above 1 pg ml-' (95%ci 88%, 100Y0). Following boosting, the geometric mean titre (GMT) rose a mean 27-fold (95%ci 19-fold, 38-fold) to 33 /g ml-', and all suqjects' titres (lower bound of 95%ci 92%) exceeded 1 pg ml-'. For hepatitis B antibodji there was a GMT of 100 mIU ml-' after the third dose, and 86% of infants (95%ci 73%, 9.5%) had antibody levels 210 mIU ml-'. After the fourth dose, there was a mean 77-fold boost (95%ci 48-fold, 130-fold) to a GMT of 860 mIU ml-' and 95% (95%ci 84%, 99%) of subjects had titres 210 mIU ml-. Diphtheria, tetanus, and pertussis antibody levels were all at acceptable levels after the first three doses and again after the fourth vaccination. The pentavalent vaccine was well tolerated at all administration times, and had a minor reactogenicity profile similar to DTPw alone 17s reported in previous studies. This study has provided preliminary evidence for both the safety and immunogenic@ of the pentavalent vaccine given as a course at 2, 4, 6 and 18 months. 0 1998 Elsevier Science Ltd. All rights reserved Keywords: DTF'w-Hib-hepatitis B; vaccine: immunogenicity routinely administered in more than 20 countries, and Global control of diphtheria, tetanus, pertussis, hepatitis B and Hib disease are realizable objectives with modern vaccine development. 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