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class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">A Model for the Coupling Between Cerebral Blood Flow and Oxygen Metabolism During Neural Stimulation</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="32478770" href="https://ucsd.academia.edu/RichardbBuxton"><img alt="Profile image of Richard b. Buxton" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Richard b. Buxton</a></div><p class="ds-work-card--detail ds2-5-body-sm">1997, Journal of Cerebral Blood Flow & Metabolism</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":45571731,"attachmentType":"pdf","workUrl":"https://www.academia.edu/13227321/A_Model_for_the_Coupling_Between_Cerebral_Blood_Flow_and_Oxygen_Metabolism_During_Neural_Stimulation"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":45571731,"attachmentType":"pdf","workUrl":"https://www.academia.edu/13227321/A_Model_for_the_Coupling_Between_Cerebral_Blood_Flow_and_Oxygen_Metabolism_During_Neural_Stimulation"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="45571731" data-landing_url="https://www.academia.edu/13227321/A_Model_for_the_Coupling_Between_Cerebral_Blood_Flow_and_Oxygen_Metabolism_During_Neural_Stimulation" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="102145135" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/102145135/Changes_in_cerebral_blood_flow_and_cerebral_oxygen_metabolism_during_neural_activation_measured_by_positron_emission_tomography_Comparison_with_changes_in_blood_oxygenation_level_dependent_contrast_measured_by_functional_magnetic_resonance_imaging">Changes in cerebral blood flow and cerebral oxygen metabolism during neural activation measured by positron emission tomography: Comparison with changes in blood oxygenation level-dependent contrast measured by functional magnetic resonance imaging</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34797888" href="https://independent.academia.edu/IwaoKanno">Iwao Kanno</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Cerebral Blood Flow &#38; 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The changes in the cerebral metabolic rate of oxygen (CMRO2) were also evaluated using a hypotension condition established by our group based on the administration of a vasodilator. Under normal conditions, CBF, PO2, and OIS showed positive signal changes (48%, 32%, and 0.42%, respectively) following stimulation. Over multiple trials, the CBF responses were well correlated with the integral of the LFP amplitudes (sigmaLFP) (Rmean=0.78), whereas a lower correlation was found between PO2 and sigmaLFP (Rmean=0.60) and between OIS and sigmaLFP (Rmean=0.54). Under the hypotension condition the LFP responses were preserved, but the CBF responses were suppressed and the PO2 and OIS changes were negative (-12% and -0.28%, respectively). In this condition, the trial-by-trial variations in PO2 and OIS were well correlated with the variability in sigmaLFPs (Rmean= -0.77 and -0.76, respectively), indicating a single trial coupling between CMRO2 changes and sigmaLFP. These findings show that CBF and CMRO2 signals are more directly correlated with neural activity compared to blood oxygen-sensitive methods such as OIS and BOLD fMRI.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses","attachmentId":42096008,"attachmentType":"pdf","work_url":"https://www.academia.edu/19361905/Trial_by_trial_relationship_between_neural_activity_oxygen_consumption_and_blood_flow_responses","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" 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The model predicted a nonlinear relationship between stimulus-evoked changes of oxygen consumption and blood flow. The magnitude of the CMRO2/CBF ratio index ( IO2) was used to indicate the degree of flow-metabolism coupling prevailing in specific areas of the brain during physiological stimulation. Therefore, the index provided a measure of the blood oxygenation level dependent (BOLD) magnetic resonance contrast. To evaluate the changes of IO2 in response to visual stimulation, the model was applied to the effect of a changing flicker rate of a visual stimulus on the magnitudes of CBF, CMRO2, and oxygen diffusion capacity, in the human brain. 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href="https://www.academia.edu/52000210/Model_of_Blood_Brain_Transfer_of_Oxygen_Explains_Nonlinear_Flow_Metabolism_Coupling_During_Stimulation_of_Visual_Cortex"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="15623296" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15623296/Evoked_cerebral_blood_flow_is_linear_to_neuronal_activation_but_independent_of_metabolic_oxygen_demand">Evoked cerebral blood flow is linear to neuronal activation but independent of metabolic oxygen demand</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34797888" href="https://independent.academia.edu/IwaoKanno">Iwao Kanno</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Congress Series, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evoked cerebral blood flow is linear to neuronal activation but independent of metabolic oxygen demand","attachmentId":43024057,"attachmentType":"pdf","work_url":"https://www.academia.edu/15623296/Evoked_cerebral_blood_flow_is_linear_to_neuronal_activation_but_independent_of_metabolic_oxygen_demand","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" 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