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A slit spectrograph was used to collect spectral image data sequences. These were analyzed using an algorithm that corrects for the wavelength dependency in the optical path lengths produced by the light scattering properties of tissue. The analysis produced the changes in the oxyand deoxygenation of hemoglobin following stimulation. Two methods of stimulation were used. One method mechanically vibrated a single whisker, the other electrically stimulated the whisker pad. The electrical stimulation intensity varied from 0.4 to 1.6 mA. The hemodynamic responses to stimulation increased as a function of intensity. At 0.4 mA they were commensurate with those from the mechanical stimulation; however, the responses at the higher levels were greater by a factor of ϳ10. For both methods of data collection, the results of the spectroscopic analysis showed an early increase in deoxygenated hemoglobin (Hbr) with no evidence for a corresponding decrease in oxygenated hemoglobin (HbO 2 ). Evidence for increased oxygen consumption (CMRO 2 ) was obtained by converting the fractional changes in blood volume (Hbt) into estimates of changes in blood flow and using the resulting time course to scale the fractional changes in Hbr. The results show an early increase CMRO 2 peaking ϳ2 s after stimulation onset. Using these methods, we find evidence for increased oxygen consumption following increased neural activity even at low levels of stimulation intensity.","publication_date":"2000,,","publication_name":"Neuroimage","grobid_abstract_attachment_id":"46434133"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Spectroscopic analysis of neural activity in brain: increased oxygen consumption following …","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [29530872]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div 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class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/30876863/_Spectroscopic_Analysis_of_Neural_Activity_in_Brain_Increased_Oxygen_Consumption_Following_Activation_of_Barrel_Cortex_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="30876870" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30876870/Increased_Oxygen_Consumption_Following_Activation_of_Brain_Theoretical_Footnotes_Using_Spectroscopic_Data_from_Barrel_Cortex">Increased Oxygen Consumption Following Activation of Brain: Theoretical Footnotes Using Spectroscopic Data from Barrel Cortex</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author 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