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Response element - Wikipedia

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class="firstHeading mw-first-heading"><span class="mw-page-title-main">Response element</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Response_Element" title="Response Element – German" lang="de" hreflang="de" data-title="Response Element" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Elemento_de_resposta" title="Elemento de resposta – Galician" lang="gl" hreflang="gl" data-title="Elemento de resposta" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%B0%98%EC%9D%91%EC%9A%94%EC%86%8C" title="반응요소 – Korean" lang="ko" hreflang="ko" data-title="반응요소" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%AD%D0%BB%D0%B5%D0%BC%D0%B5%D0%BD%D1%82%D1%8B_%D0%BE%D1%82%D0%BA%D0%BB%D0%B8%D0%BA%D0%B0" title="Элементы отклика – Russian" lang="ru" hreflang="ru" data-title="Элементы отклика" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Response_element" title="Response element – Turkish" lang="tr" hreflang="tr" data-title="Response element" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%93%8D%E5%BA%94%E5%85%83%E4%BB%B6" title="响应元件 – Chinese" lang="zh" hreflang="zh" data-title="响应元件" data-language-autonym="中文" data-language-local-name="Chinese" 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class="mw-redirectedfrom">(Redirected from <a href="/w/index.php?title=Hormone_response_element&amp;redirect=no" class="mw-redirect" title="Hormone response element">Hormone response element</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><p><i>Response elements</i> are short sequences of <a href="/wiki/DNA" title="DNA">DNA</a> within a gene <a href="/wiki/Promoter_(genetics)" title="Promoter (genetics)">promoter</a> or <a href="/wiki/Enhancer_(genetics)" title="Enhancer (genetics)">enhancer</a> region that are able to bind specific <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factors</a> and regulate <a href="/wiki/Transcription_(genetics)" class="mw-redirect" title="Transcription (genetics)">transcription</a> of <a href="/wiki/Gene" title="Gene">genes</a>. </p><p>Under conditions of stress, a transcription activator protein binds to the response element and stimulates transcription. If the same response element sequence is located in the control regions of different genes, then these genes will be activated by the same stimuli, thus producing a coordinated response. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Hormone_response_element">Hormone response element</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Response_element&amp;action=edit&amp;section=1" title="Edit section: Hormone response element"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A <b>hormone response element</b> (HRE) is a short sequence of <a href="/wiki/DNA" title="DNA">DNA</a> within the <a href="/wiki/Promoter_(biology)" class="mw-redirect" title="Promoter (biology)">promoter</a> of a gene, that is able to bind to a specific <a href="/wiki/Hormone_receptor" title="Hormone receptor">hormone receptor</a> complex and therefore regulate <a href="/wiki/Transcription_(genetics)" class="mw-redirect" title="Transcription (genetics)">transcription</a>.<sup id="cite_ref-web1_1-0" class="reference"><a href="#cite_note-web1-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> The sequence is most commonly a pair of <a href="/wiki/Inverted_repeat" title="Inverted repeat">inverted repeats</a> separated by three nucleotides, which also indicates that the receptor binds as a <a href="/wiki/Protein_dimer" title="Protein dimer">dimer</a>. Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE. This regulates the transcription of genes signalled by the steroid hormone. </p><p>A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.<sup id="cite_ref-isbn0-7167-4366-3_2-0" class="reference"><a href="#cite_note-isbn0-7167-4366-3-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p><p>HRE are used in <a href="/wiki/Transgenic" class="mw-redirect" title="Transgenic">transgenic</a> animal cells as <a href="/wiki/Inducer_(biology)" class="mw-redirect" title="Inducer (biology)">inducers</a> of gene expression. </p><p>Examples of HREs include estrogen response elements and androgen response elements. </p> <div class="mw-heading mw-heading2"><h2 id="Examples">Examples</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Response_element&amp;action=edit&amp;section=2" title="Edit section: Examples"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Examples of response elements include: </p> <ul><li><a href="/wiki/Nuclear_receptor" title="Nuclear receptor">Nuclear receptor</a> (NR) response elements &#8211; two 6-meric repeats for dimeric binding <ul><li>Type 1 NR response elements: inverted repeat<sup id="cite_ref-web1_1-1" class="reference"><a href="#cite_note-web1-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> <ul><li>estrogen response elements (EREs)</li> <li>androgen response elements (AREs)</li> <li>glucocorticoid response elements (GREs)</li></ul></li> <li>Type 2 NR response elements: direct repeat <a href="/wiki/FASTA_format#Sequence_representation" title="FASTA format">RGKTCA</a> motifs, canonically AGGTCA<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> <ul><li><a href="/wiki/VDRE" title="VDRE">Vitamin D response element (VDRE)</a></li> <li>Retinoic acid response elements (RAREs)</li> <li><a href="/wiki/RAR-related_orphan_receptor_alpha#Mechanism" title="RAR-related orphan receptor alpha">ROR-response element</a></li> <li>Thyroid hormone response element</li> <li>Growth hormone response element (GHRE)</li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor#Physiological_function" title="Peroxisome proliferator-activated receptor">Peroxisome proliferator hormone response elements (PPREs)</a></li></ul></li></ul></li> <li><a href="/wiki/CAMP_response_element" class="mw-redirect" title="CAMP response element">cAMP response element (CRE)</a></li> <li><a href="/wiki/B_recognition_element" title="B recognition element">B recognition element</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor#DNA_binding_(xenobiotic_response_element_–_XRE)" title="Aryl hydrocarbon receptor">AhR-, dioxin- or xenobiotic- responsive element</a> (XRE)</li> <li><a href="/wiki/Hypoxia-inducible_factor#Mechanism" title="Hypoxia-inducible factor">Hypoxia-responsive elements</a> (HREs)</li> <li><a href="/wiki/Serum_response_factor#Function" title="Serum response factor">Serum response element (SRE)</a></li> <li><a href="/wiki/MTF1#Function" title="MTF1">Metal-responsive element (MRE)</a></li> <li>DNA damage response element (DRE)</li> <li><a href="/wiki/Interferon#Downstream_signaling" title="Interferon">IFN-stimulated response elements (ISREs)</a></li> <li><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR029309">Calcium-response element CaRE1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">Antioxidant response element (ARE)</a></li> <li>p53 response element</li> <li><a href="/wiki/Sterol_regulatory_element-binding_protein#Function" title="Sterol regulatory element-binding protein">Sterol regulatory element</a> (StRE)</li> <li><a href="/wiki/Polycomb-group_proteins" title="Polycomb-group proteins">Polycomb</a> response elements (PREs)</li> <li><a href="/wiki/HIV_Rev_response_element" title="HIV Rev response element">Rev response element (RRE)</a></li> <li><a href="/wiki/TCF/LEF_family#History" title="TCF/LEF family">Wnt response element</a> (WRE), core CTTTG</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Response_element&amp;action=edit&amp;section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output 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(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFKimball2011" class="citation web cs1">Kimball JW (25 April 2011). <a rel="nofollow" class="external text" href="http://www.biology-pages.info/S/SteroidREs.html">"Steroid Hormone Receptors and their Response Elements"</a>. <i>Kimball's Biology Pages</i>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Kimball%27s+Biology+Pages&amp;rft.atitle=Steroid+Hormone+Receptors+and+their+Response+Elements&amp;rft.date=2011-04-25&amp;rft.aulast=Kimball&amp;rft.aufirst=John+W.&amp;rft_id=http%3A%2F%2Fwww.biology-pages.info%2FS%2FSteroidREs.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AResponse+element" class="Z3988"></span></span> </li> <li id="cite_note-isbn0-7167-4366-3-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-isbn0-7167-4366-3_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKriegerScottMatsudairaLodish2003" class="citation book cs1">Krieger M, Scott MP, Matsudaira PT, Lodish HF, Darnell JE, Lawrence Z, Kaiser C, Berk A (2003). <span class="id-lock-registration" title="Free registration required"><a rel="nofollow" class="external text" href="https://archive.org/details/molecularcellbio00harv/page/973"><i>Molecular Cell Biology</i></a></span> (Fifth&#160;ed.). San Francisco: W.H. Freeman. p.&#160;<a rel="nofollow" class="external text" href="https://archive.org/details/molecularcellbio00harv/page/973">973 pages</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/0-7167-4366-3" title="Special:BookSources/0-7167-4366-3"><bdi>0-7167-4366-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Molecular+Cell+Biology&amp;rft.place=San+Francisco&amp;rft.pages=973+pages&amp;rft.edition=Fifth&amp;rft.pub=W.H.+Freeman&amp;rft.date=2003&amp;rft.isbn=0-7167-4366-3&amp;rft.aulast=Krieger&amp;rft.aufirst=Monty&amp;rft.au=Scott%2C+Matthew+P&amp;rft.au=Matsudaira%2C+Paul+T.&amp;rft.au=Lodish%2C+Harvey+F.&amp;rft.au=Darnell%2C+James+E.&amp;rft.au=Lawrence%2C+Zipursky&amp;rft.au=Kaiser%2C+Chris&amp;rft.au=Berk%2C+Arnold&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fmolecularcellbio00harv%2Fpage%2F973&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AResponse+element" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPenvoseKeenanBrayRamlall2019" class="citation journal cs1">Penvose, A; Keenan, JL; Bray, D; Ramlall, V; Siggers, T (7 June 2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555819">"Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity"</a>. <i>Nature Communications</i>. <b>10</b> (1): 2514. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2019NatCo..10.2514P">2019NatCo..10.2514P</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fs41467-019-10264-3">10.1038/s41467-019-10264-3</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555819">6555819</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31175293">31175293</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Nature+Communications&amp;rft.atitle=Comprehensive+study+of+nuclear+receptor+DNA+binding+provides+a+revised+framework+for+understanding+receptor+specificity.&amp;rft.volume=10&amp;rft.issue=1&amp;rft.pages=2514&amp;rft.date=2019-06-07&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6555819%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F31175293&amp;rft_id=info%3Adoi%2F10.1038%2Fs41467-019-10264-3&amp;rft_id=info%3Abibcode%2F2019NatCo..10.2514P&amp;rft.aulast=Penvose&amp;rft.aufirst=A&amp;rft.au=Keenan%2C+JL&amp;rft.au=Bray%2C+D&amp;rft.au=Ramlall%2C+V&amp;rft.au=Siggers%2C+T&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6555819&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AResponse+element" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Response_element&amp;action=edit&amp;section=4" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=response+element">response+element</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline 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.navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Transcription_(Bacterial,_Eukaryotic)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output 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template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Transcription" title="Template talk:Transcription"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Transcription" title="Special:EditPage/Template:Transcription"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Transcription_(Bacterial,_Eukaryotic)" style="font-size:114%;margin:0 4em"><a href="/wiki/Transcription_(genetics)" class="mw-redirect" title="Transcription (genetics)">Transcription</a> (<a href="/wiki/Bacterial_transcription" title="Bacterial transcription">Bacterial</a>, <a href="/wiki/Eukaryotic_transcription" title="Eukaryotic transcription">Eukaryotic</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Transcriptional_regulation" title="Transcriptional regulation">Transcriptional regulation</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">prokaryotic</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Operon" title="Operon">Operon</a> <ul><li><a href="/wiki/Lac_operon" title="Lac operon">lac operon</a></li> <li><a href="/wiki/Trp_operon" title="Trp operon">trp operon</a></li> <li><a href="/wiki/Gab_operon" title="Gab operon">gab operon</a></li> <li><a href="/wiki/Gua_Operon" title="Gua Operon">Gua Operon</a></li> <li><a href="/wiki/L-arabinose_operon" title="L-arabinose operon">ara operon</a></li> <li><a href="/wiki/Gal_operon" title="Gal operon">gal operon</a></li></ul></li> <li><a href="/wiki/Repressor" title="Repressor">Repressor</a> <ul><li><a href="/wiki/Lac_repressor" title="Lac repressor">lac repressor</a></li> <li><a href="/wiki/Tryptophan_repressor" title="Tryptophan repressor">trp repressor</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">eukaryotic</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Histone-modifying_enzymes" title="Histone-modifying enzymes">Histone-modifying enzymes</a><br />(<a href="/wiki/Histone" title="Histone">histone</a>/<a href="/wiki/Nucleosome" title="Nucleosome">nucleosome</a>):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Histone_methylation" title="Histone methylation">Histone methylation</a>/<a href="/wiki/Histone_methyltransferase" title="Histone methyltransferase">Histone methyltransferase</a> <ul><li><a href="/wiki/EZH2" title="EZH2">EZH2</a></li></ul></li> <li><a href="/wiki/Demethylase" title="Demethylase">Histone demethylase</a></li> <li><a href="/wiki/Histone_acetylation_and_deacetylation" title="Histone acetylation and deacetylation">Histone acetylation and deacetylation</a> <ul><li><a href="/wiki/Histone_deacetylase" title="Histone deacetylase">Histone deacetylase</a> <a href="/wiki/HDAC1" title="HDAC1">HDAC1</a></li> <li><a href="/wiki/Histone_acetyltransferase" title="Histone acetyltransferase">Histone acetyltransferase</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/DNA_methylation" title="DNA methylation">DNA methylation</a>:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><ul><li><a href="/wiki/DNA_methyltransferase" title="DNA methyltransferase">DNA methyltransferase</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chromatin_remodeling" title="Chromatin remodeling">Chromatin remodeling</a>:</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CHD7" title="CHD7">CHD7</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">both</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Transcription_coregulator" title="Transcription coregulator">Transcription coregulator</a> <ul><li><a href="/wiki/Activator_(genetics)" title="Activator (genetics)">Activator</a></li> <li><a href="/wiki/Coactivator_(genetics)" title="Coactivator (genetics)">Coactivator</a></li> <li><a href="/wiki/Corepressor" title="Corepressor">Corepressor</a></li></ul></li> <li><a href="/wiki/Inducer" title="Inducer">Inducer</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Promotion</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Promoter_(genetics)" title="Promoter (genetics)">Promoter</a> <ul><li><a href="/wiki/Pribnow_box" title="Pribnow box">Pribnow box</a></li> <li><a href="/wiki/TATA_box" title="TATA box">TATA box</a></li> <li><a href="/wiki/B_recognition_element" title="B recognition element">BRE</a></li> <li><a href="/wiki/CAAT_box" title="CAAT box">CAAT box</a></li> <li><a class="mw-selflink selflink">Response element</a></li></ul></li> <li><a href="/wiki/Enhancer_(genetics)" title="Enhancer (genetics)">Enhancer</a> <ul><li><a href="/wiki/E-box" title="E-box">E-box</a></li> <li><a class="mw-selflink selflink">Response element</a></li></ul></li> <li><a href="/wiki/Insulator_(genetics)" title="Insulator (genetics)">Insulator</a></li> <li><a href="/wiki/Silencer_(DNA)" class="mw-redirect" title="Silencer (DNA)">Silencer</a></li> <li><a href="/wiki/Internal_control_region" title="Internal control region">Internal control region</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Initiation</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bacterial_transcription#Initiation" title="Bacterial transcription">Bacterial</a></li> <li><a href="/wiki/Eukaryotic_transcription#Initiation" title="Eukaryotic transcription">Eukaryotic</a></li> <li><a href="/wiki/Archaeal_transcription_factor_B" title="Archaeal transcription factor B">Archaeal transcription factor B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Elongation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bacterial_transcription#Elongation" title="Bacterial transcription">bacterial</a> <a href="/wiki/RNA_polymerase" title="RNA polymerase">RNA polymerase</a>: <a href="/wiki/RpoB" title="RpoB">rpoB</a></li> <li><a href="/wiki/Eukaryotic_transcription#Transcription_process" title="Eukaryotic transcription">eukaryotic</a> <a href="/wiki/RNA_polymerase" title="RNA polymerase">RNA polymerase</a>: <a href="/wiki/RNA_polymerase_II" title="RNA polymerase II">RNA polymerase II</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Termination<br />(<a href="/wiki/Bacterial_transcription#Termination" title="Bacterial transcription">bacterial</a>,<br /> <a href="/wiki/Eukaryotic_transcription#Termination" title="Eukaryotic transcription">eukaryotic</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Terminator_(genetics)" title="Terminator (genetics)">Terminator</a></li> <li><a href="/wiki/Intrinsic_termination" title="Intrinsic termination">Intrinsic termination</a></li> <li><a href="/wiki/Rho_factor" title="Rho factor">Rho factor</a></li></ul> </div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐api‐int.codfw.main‐6c85b6797‐x8rfh Cached time: 20241030063003 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.274 seconds Real time usage: 0.318 seconds Preprocessor visited node count: 470/1000000 Post‐expand include size: 29883/2097152 bytes Template argument size: 134/2097152 bytes Highest expansion depth: 8/100 Expensive parser function count: 1/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 21336/5000000 bytes Lua time usage: 0.188/10.000 seconds Lua memory usage: 3494701/52428800 bytes Number of Wikibase entities loaded: 0/400 --> <!-- Transclusion expansion time 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