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Material and methods: Retrospective observational cohort study. Data of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_40029023" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: In the present study, perioperative outcomes of laparoscopy (LPS) were compared to open surgery (OS) for the treatment of large adnexal masses (AM). Material and methods: Retrospective observational cohort study. Data of consecutive patients who underwent ovarian cystectomy or salpingo-oophorectomy for large AM (diameter ≥10 cm) at a referral minimally invasive gynecologic center were analyzed. Propensity score match (PSM) analysis was used to minimize covariate imbalances between the two groups. Results: Overall 330 patients, 285 (86.4%) LPSs and 45 (13.6%) OSs were included. PSM showed LPS (vs. OS) to be associated with less intraoperative blood loss (mL: 131.1 ± 52.6 vs. 545.5 ± 101.2; p = .007), shorter operative time (min: 84.8 ± 77.9 vs. 123.7 ± 70.1; p < .001), but higher rate of spillage (54.5% vs. 12.1%; p < .001). Among the LPS group, a positive correlation between AM size and both conversion to open surgery and need for mini-laparotomy was found (p < .05). Conclusions: An accurate patient selection, a dedicated workup, and an appropriate counselling are mandatory before LPS for large AM. The increased risks of intraoperative spillage associated with the minimally invasive approach should be acknowledged.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/40029023" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c4895ae26e963d16a4e50970f322e97a" rel="nofollow" data-download="{"attachment_id":60225467,"asset_id":40029023,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/60225467/download_file?st=MTczMjc0NTAyMiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12242463" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a><script data-card-contents-for-user="12242463" type="text/json">{"id":12242463,"first_name":"Antonio Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-40029023">+1</span><div class="hidden js-additional-users-40029023"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://azospvr.academia.edu/SimoneGarzon">Simone Garzon</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-40029023'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-40029023').html(); 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Material and methods: Retrospective observational cohort study. Data of consecutive patients who underwent ovarian cystectomy or salpingo-oophorectomy for large AM (diameter ≥10 cm) at a referral minimally invasive gynecologic center were analyzed. Propensity score match (PSM) analysis was used to minimize covariate imbalances between the two groups. Results: Overall 330 patients, 285 (86.4%) LPSs and 45 (13.6%) OSs were included. PSM showed LPS (vs. OS) to be associated with less intraoperative blood loss (mL: 131.1 ± 52.6 vs. 545.5 ± 101.2; p = .007), shorter operative time (min: 84.8 ± 77.9 vs. 123.7 ± 70.1; p \u003c .001), but higher rate of spillage (54.5% vs. 12.1%; p \u003c .001). Among the LPS group, a positive correlation between AM size and both conversion to open surgery and need for mini-laparotomy was found (p \u003c .05). Conclusions: An accurate patient selection, a dedicated workup, and an appropriate counselling are mandatory before LPS for large AM. The increased risks of intraoperative spillage associated with the minimally invasive approach should be acknowledged.","publication":"Minim Invasive Ther Allied Technol.","publication_with_fallback":"Minim Invasive Ther Allied Technol.","downloadable_attachments":[{"id":60225467,"asset_id":40029023,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/60225467/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/60225467/205_-_Surgical_treatment_of_large_adnexal_masses20190807-103904-1ypfarg-libre.pdf?1565182836=\u0026response-content-disposition=attachment%3B+filename%3DSurgical_treatment_of_large_adnexal_mass.pdf\u0026Expires=1732748622\u0026Signature=DxP49iw-OUEt-GRn6oKGTkAX7yiDydY84v-6q4ZKJ-859YPNH2JtagNnef-kFFjQIxae1hdCDPGzCjMBszuRMCtmN0nPsmrNMsu42~C1cdwTaZRQWtb6p2MoN6CVeRnFc9-blqtvie3M8FCDw~~iM9YBGzkYm-N~QhuXwzvq~SfiuQmmIPtUQaWzr5m131hLBtpf25DMF~2txnxENL1Sja~HkzIEWRf82fpqCrwsscD3cGTf0qzV0oFbUIud8PibLPN6JxPF1ndv7QkPVOhgOl8bAILKkl0e5mIVYQjN8ScSuLqBRbFmKVsBYDbMR~dz9HUe6BdkqEe8nn4y~MdOPw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/60225467/download_file?st=MTczMjc0NTAyMiw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/60225467/mini_magick20190807-17025-2azyau.png?1565182177"}],"downloadable_attachments_with_full_thumbnails":[{"id":60225467,"asset_id":40029023,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/60225467/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/60225467/205_-_Surgical_treatment_of_large_adnexal_masses20190807-103904-1ypfarg-libre.pdf?1565182836=\u0026response-content-disposition=attachment%3B+filename%3DSurgical_treatment_of_large_adnexal_mass.pdf\u0026Expires=1732748622\u0026Signature=DxP49iw-OUEt-GRn6oKGTkAX7yiDydY84v-6q4ZKJ-859YPNH2JtagNnef-kFFjQIxae1hdCDPGzCjMBszuRMCtmN0nPsmrNMsu42~C1cdwTaZRQWtb6p2MoN6CVeRnFc9-blqtvie3M8FCDw~~iM9YBGzkYm-N~QhuXwzvq~SfiuQmmIPtUQaWzr5m131hLBtpf25DMF~2txnxENL1Sja~HkzIEWRf82fpqCrwsscD3cGTf0qzV0oFbUIud8PibLPN6JxPF1ndv7QkPVOhgOl8bAILKkl0e5mIVYQjN8ScSuLqBRbFmKVsBYDbMR~dz9HUe6BdkqEe8nn4y~MdOPw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/60225467/download_file?st=MTczMjc0NTAyMiw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/60225467/mini_magick20190807-17025-2azyau.png?1565182177"}],"has_pdf":true,"has_fulltext":true,"page_count":9,"ordered_authors":[{"id":12242463,"first_name":"Antonio Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"},{"id":43686761,"first_name":"Simone","last_name":"Garzon","domain_name":"azospvr","page_name":"SimoneGarzon","display_name":"Simone Garzon","profile_url":"https://azospvr.academia.edu/SimoneGarzon","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics","nofollow":false},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology","nofollow":false},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"}],"publication_year":2019,"publication_year_with_fallback":2019,"paper_rank":null,"all_time_views":57,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_40114343 coauthored" data-work_id="40114343" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/40114343/Vaginal_flap_for_urethral_neomeatus_reconstruction_after_radical_surgery_for_vulvar_cancer_a_retrospective_cohort_analysis">Vaginal flap for urethral neomeatus reconstruction after radical surgery for vulvar cancer: a retrospective cohort analysis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">INTRODUCTION: Partial urethrectomy during radical surgery for vulvar cancer may help avoid adjuvant radiotherapy in some patients. This study aimed to evaluate surgical, oncologic, and urinary outcomes of a new surgical technique based on... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_40114343" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">INTRODUCTION:<br />Partial urethrectomy during radical surgery for vulvar cancer may help avoid adjuvant radiotherapy in some patients. This study aimed to evaluate surgical, oncologic, and urinary outcomes of a new surgical technique based on vaginal flap to perform neomeatus reconstruction after distal urethral resection in radical surgery for vulvar cancer.<br /><br />METHODS:<br />Retrospective cohort study between January 2005 and December 2017. We recorded data on pre- and post-operative urinary symptoms, surgical procedures, complications, adjuvant therapy, and follow-up of all patients who underwent surgery for vulvar cancer and had distal urethral resection and neomeatus reconstruction with the proposed technique. The reconstruction was based on the development of a vaginal flap in which a circular opening was created to become the neo-outlet of the urethra.<br /><br />RESULTS:<br />Of a total of 200 patients with vulvar cancer operated with curative intent, 33 (16.5%) underwent distal urethral resection and neomeatus reconstruction during surgery (median age 73 (range 57-89) years; median body mass index 25.3 (range 16.3-36.4) kg/m2). Urethrectomy allowed the avoidance of adjuvant radiotherapy in 15/33 (45.5%) patients. No case of dehiscence was reported at the site of neomeatus. After a median follow-up of 39 (range 14-151) months, only one case of deviated urinary stream (3%) and no cases of neomeatus stricture were reported. Six (18.2%) patients developed or worsened urinary incontinence after urethral resection and neomeatus reconstruction, and there was no difference in the prevalence of urethral compressor muscle involvement during urethrectomy (p=0.19) and adjuvant radiotherapy (p=1.00). No recurrences were reported at urethral margins.<br /><br />CONCLUSIONS:<br />Distal urethral resection and neomeatus reconstruction seem to be associated with adequate healing and low complication rates, such as dehiscence, stenosis, and flux deviation/dribbling. New-onset or worsened urinary incontinence does not seem to be associated with urethral compressor muscle involvement during urethral resection or adjuvant radiotherapy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/40114343" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="186040c7b9516a6eaa4016a07648cda0" rel="nofollow" data-download="{"attachment_id":60326841,"asset_id":40114343,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/60326841/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12242463" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a><script data-card-contents-for-user="12242463" type="text/json">{"id":12242463,"first_name":"Antonio Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-40114343">+1</span><div class="hidden js-additional-users-40114343"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://azospvr.academia.edu/SimoneGarzon">Simone Garzon</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-40114343'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-40114343').html(); 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This study aimed to evaluate surgical, oncologic, and urinary outcomes of a new surgical technique based on vaginal flap to perform neomeatus reconstruction after distal urethral resection in radical surgery for vulvar cancer.\n\nMETHODS:\nRetrospective cohort study between January 2005 and December 2017. We recorded data on pre- and post-operative urinary symptoms, surgical procedures, complications, adjuvant therapy, and follow-up of all patients who underwent surgery for vulvar cancer and had distal urethral resection and neomeatus reconstruction with the proposed technique. The reconstruction was based on the development of a vaginal flap in which a circular opening was created to become the neo-outlet of the urethra.\n\nRESULTS:\nOf a total of 200 patients with vulvar cancer operated with curative intent, 33 (16.5%) underwent distal urethral resection and neomeatus reconstruction during surgery (median age 73 (range 57-89) years; median body mass index 25.3 (range 16.3-36.4) kg/m2). Urethrectomy allowed the avoidance of adjuvant radiotherapy in 15/33 (45.5%) patients. No case of dehiscence was reported at the site of neomeatus. After a median follow-up of 39 (range 14-151) months, only one case of deviated urinary stream (3%) and no cases of neomeatus stricture were reported. Six (18.2%) patients developed or worsened urinary incontinence after urethral resection and neomeatus reconstruction, and there was no difference in the prevalence of urethral compressor muscle involvement during urethrectomy (p=0.19) and adjuvant radiotherapy (p=1.00). No recurrences were reported at urethral margins.\n\nCONCLUSIONS:\nDistal urethral resection and neomeatus reconstruction seem to be associated with adequate healing and low complication rates, such as dehiscence, stenosis, and flux deviation/dribbling. New-onset or worsened urinary incontinence does not seem to be associated with urethral compressor muscle involvement during urethral resection or adjuvant radiotherapy.","publication":"Int J Gynecol Cancer.","publication_with_fallback":"Int J Gynecol 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Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"},{"id":43686761,"first_name":"Simone","last_name":"Garzon","domain_name":"azospvr","page_name":"SimoneGarzon","display_name":"Simone Garzon","profile_url":"https://azospvr.academia.edu/SimoneGarzon","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics","nofollow":false},{"id":121291,"name":"Recovery","url":"https://www.academia.edu/Documents/in/Recovery","nofollow":false},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"}],"publication_year":2019,"publication_year_with_fallback":2019,"paper_rank":null,"all_time_views":20,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_40532918 coauthored" data-work_id="40532918" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/40532918/Hysteroscopic_outpatient_metroplasty_for_T_shaped_uterus_in_women_with_reproductive_failure_Results_from_a_large_prospective_cohort_study">Hysteroscopic outpatient metroplasty for T-shaped uterus in women with reproductive failure: Results from a large prospective cohort study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: To evaluate the effectiveness of hysteroscopic outpatient metroplasty in women with T-shaped uterus and primary reproductive failure. Study Design: Prospective cohort study including nulliparous women with primary unexplained... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_40532918" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: To evaluate the effectiveness of hysteroscopic outpatient metroplasty in women with T-shaped uterus and primary reproductive failure. Study Design: Prospective cohort study including nulliparous women with primary unexplained infertility, repeated in vitro fertilization (IVF) failure or recurrent spontaneous miscarriage and T-shaped uterus anomaly not diethylstilbestrol-related, diagnosed by 3D ultrasound and diagnostic hysteroscopy. Between January 2015 and December 2017, hysteroscopic metroplasty was performed in outpatient settings with a 5-mm diameter hysteroscope and 5-Fr operative scissors. After 3 months, expectant management was proposed to women with unexplained couple infertility or recurrent spontaneous miscarriages, and IVF treatment was proposed after 6 months without natural conception or immediately to couple with repeated IVF failure. Minimum follow-up was planned for 1 year. Results: A total of 63 women were included, and only 60 tried to conceive after metroplasty. Hysteroscopic procedures were performed without complications. Clinical pregnancy rate after metroplasty was 83.3% (n = 50/60) (p < 0.001), and the live birth rate was 63.3% (n = 38/60) (p < 0.001). Cesarean section rate was 26.3%. No pregnancy complications potentially related to uterine surgery were reported. The abortion rate was 12% (n = 6/50) (p < 0.001). Conclusion: In women with primary reproductive failure and T-shaped uterus, hysteroscopic metroplasty seems to be effective to improve reproductive outcomes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/40532918" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="995943403fd94833b5eff11b55f2e7bf" rel="nofollow" data-download="{"attachment_id":60807483,"asset_id":40532918,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/60807483/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12242463" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a><script data-card-contents-for-user="12242463" type="text/json">{"id":12242463,"first_name":"Antonio Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-40532918">+1</span><div class="hidden js-additional-users-40532918"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://azospvr.academia.edu/SimoneGarzon">Simone Garzon</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-40532918'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-40532918').html(); 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Study Design: Prospective cohort study including nulliparous women with primary unexplained infertility, repeated in vitro fertilization (IVF) failure or recurrent spontaneous miscarriage and T-shaped uterus anomaly not diethylstilbestrol-related, diagnosed by 3D ultrasound and diagnostic hysteroscopy. Between January 2015 and December 2017, hysteroscopic metroplasty was performed in outpatient settings with a 5-mm diameter hysteroscope and 5-Fr operative scissors. After 3 months, expectant management was proposed to women with unexplained couple infertility or recurrent spontaneous miscarriages, and IVF treatment was proposed after 6 months without natural conception or immediately to couple with repeated IVF failure. Minimum follow-up was planned for 1 year. Results: A total of 63 women were included, and only 60 tried to conceive after metroplasty. Hysteroscopic procedures were performed without complications. Clinical pregnancy rate after metroplasty was 83.3% (n = 50/60) (p \u003c 0.001), and the live birth rate was 63.3% (n = 38/60) (p \u003c 0.001). Cesarean section rate was 26.3%. No pregnancy complications potentially related to uterine surgery were reported. The abortion rate was 12% (n = 6/50) (p \u003c 0.001). Conclusion: In women with primary reproductive failure and T-shaped uterus, hysteroscopic metroplasty seems to be effective to improve reproductive outcomes.","publication":"Eur J Obstet Gynecol Reprod Biol.","publication_with_fallback":"Eur J Obstet Gynecol Reprod Biol.","downloadable_attachments":[{"id":60807483,"asset_id":40532918,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/60807483/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/60807483/211_-_T-shaped_uterus_and_reproductive_outcomes20191005-60594-ujxcu3-libre.pdf?1570299979=\u0026response-content-disposition=attachment%3B+filename%3DHysteroscopic_outpatient_metroplasty_for.pdf\u0026Expires=1732747681\u0026Signature=Xui9D39fcZQylTYYvj5qtohelWuiDYnmmtZI2OuJhfC4oeRXAEUsajOOtSqEoZBpfTLd5sfVpx3Ibxlq0CWPVNgeWHYvo0ZpFamp3736GGdL1b2IKVRTJ8XzoNpJoMfDBn-AgQW3x1K6cT2CRdg36hvfF768DTNQukCzixJ5-5MSr2sbn3oUqgnxOKDtoLuSGDhQ6lWXnGvttLbaldu~FvnTPskg5LSZIkDhBpDUfDdCWUeOlwzOdFGFy36BkP3rgTXT2m8tAy3-e8a0beLkB3AO3kQcWX34~oIjjNWbquIaAztmnkLinPn1WiMoOrF4mId9pfUknbgTvpdrS8jojA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/60807483/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/60807483/mini_magick20191005-18756-wcb5wm.png?1570299976"}],"downloadable_attachments_with_full_thumbnails":[{"id":60807483,"asset_id":40532918,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/60807483/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/60807483/211_-_T-shaped_uterus_and_reproductive_outcomes20191005-60594-ujxcu3-libre.pdf?1570299979=\u0026response-content-disposition=attachment%3B+filename%3DHysteroscopic_outpatient_metroplasty_for.pdf\u0026Expires=1732747681\u0026Signature=Xui9D39fcZQylTYYvj5qtohelWuiDYnmmtZI2OuJhfC4oeRXAEUsajOOtSqEoZBpfTLd5sfVpx3Ibxlq0CWPVNgeWHYvo0ZpFamp3736GGdL1b2IKVRTJ8XzoNpJoMfDBn-AgQW3x1K6cT2CRdg36hvfF768DTNQukCzixJ5-5MSr2sbn3oUqgnxOKDtoLuSGDhQ6lWXnGvttLbaldu~FvnTPskg5LSZIkDhBpDUfDdCWUeOlwzOdFGFy36BkP3rgTXT2m8tAy3-e8a0beLkB3AO3kQcWX34~oIjjNWbquIaAztmnkLinPn1WiMoOrF4mId9pfUknbgTvpdrS8jojA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/60807483/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/60807483/mini_magick20191005-18756-wcb5wm.png?1570299976"}],"has_pdf":true,"has_fulltext":true,"page_count":6,"ordered_authors":[{"id":12242463,"first_name":"Antonio Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"},{"id":43686761,"first_name":"Simone","last_name":"Garzon","domain_name":"azospvr","page_name":"SimoneGarzon","display_name":"Simone Garzon","profile_url":"https://azospvr.academia.edu/SimoneGarzon","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery","nofollow":false},{"id":4559,"name":"Reproduction","url":"https://www.academia.edu/Documents/in/Reproduction","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false},{"id":74399,"name":"IVF","url":"https://www.academia.edu/Documents/in/IVF","nofollow":false},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":230950,"name":"Hysteroscopy","url":"https://www.academia.edu/Documents/in/Hysteroscopy"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"}],"publication_year":2019,"publication_year_with_fallback":2019,"paper_rank":null,"all_time_views":138,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_40532921 coauthored" data-work_id="40532921" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/40532921/Non_syndromic_monogenic_female_infertility">Non-syndromic monogenic female infertility</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Infertility is a significant clinical problem. It affects 8-12% of couples worldwide, about 30% of whom are diagnosed with idiopathic infertility (infertility lacking any obvious cause). In 2010, the World Health Organization calculated... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_40532921" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Infertility is a significant clinical problem. It affects 8-12% of couples worldwide, about 30% of whom are diagnosed with idiopathic infertility (infertility lacking any obvious cause). In 2010, the World Health Organization calculated that 1.9% of child-seeking women aged 20-44 years were unable to have a first live birth (primary infertility), and 10.5% of child-seeking women with a prior live birth were unable to have an additional live birth (secondary infertility). About 50% of all infertility cases are due to female reproductive defects. Several chromosome aberrations, diagnosed by karyotype analysis, have long been known to be associated with female infertility and monogenic mutations have also recently been found. Female infertility primarily involves oogenesis. The following phenotypes are associated with monogenic female infertility: premature ovarian failure, ovarian dysgenesis, oocyte maturation defects, early embryo arrest, polycystic ovary syndrome and recurrent pregnancy loss. Here we summarize the genetic causes of non-syndromic monogenic female infertility and the genes analyzed by our genetic test.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/40532921" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="223b3d41370a629c17c0624174a3650e" rel="nofollow" data-download="{"attachment_id":60807488,"asset_id":40532921,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/60807488/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12242463" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a><script data-card-contents-for-user="12242463" type="text/json">{"id":12242463,"first_name":"Antonio Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-40532921">+1</span><div class="hidden js-additional-users-40532921"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://azospvr.academia.edu/SimoneGarzon">Simone Garzon</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-40532921'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-40532921').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_40532921 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="40532921"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 40532921; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=40532921]").text(description); $(".js-view-count-work_40532921").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_40532921").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="40532921"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="647" href="https://www.academia.edu/Documents/in/Surgery">Surgery</a>, <script data-card-contents-for-ri="647" type="text/json">{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4480" href="https://www.academia.edu/Documents/in/Population_Genetics">Population Genetics</a>, <script data-card-contents-for-ri="4480" type="text/json">{"id":4480,"name":"Population Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=40532921]'), work: {"id":40532921,"title":"Non-syndromic monogenic female infertility","created_at":"2019-10-05T11:20:37.801-07:00","owner_id":12242463,"url":"https://www.academia.edu/40532921/Non_syndromic_monogenic_female_infertility","slug":"Non_syndromic_monogenic_female_infertility","dom_id":"work_40532921","summary":"Infertility is a significant clinical problem. It affects 8-12% of couples worldwide, about 30% of whom are diagnosed with idiopathic infertility (infertility lacking any obvious cause). In 2010, the World Health Organization calculated that 1.9% of child-seeking women aged 20-44 years were unable to have a first live birth (primary infertility), and 10.5% of child-seeking women with a prior live birth were unable to have an additional live birth (secondary infertility). About 50% of all infertility cases are due to female reproductive defects. Several chromosome aberrations, diagnosed by karyotype analysis, have long been known to be associated with female infertility and monogenic mutations have also recently been found. Female infertility primarily involves oogenesis. The following phenotypes are associated with monogenic female infertility: premature ovarian failure, ovarian dysgenesis, oocyte maturation defects, early embryo arrest, polycystic ovary syndrome and recurrent pregnancy loss. Here we summarize the genetic causes of non-syndromic monogenic female infertility and the genes analyzed by our genetic test.","publication":"Acta Biomed.","publication_with_fallback":"Acta Biomed.","downloadable_attachments":[{"id":60807488,"asset_id":40532921,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/60807488/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/60807488/212_-_Non-syndromic_monogenic_female_infertility20191005-58269-bbm4lj-libre.pdf?1570299979=\u0026response-content-disposition=attachment%3B+filename%3DNon_syndromic_monogenic_female_infertili.pdf\u0026Expires=1732748623\u0026Signature=caXcMCMHTXa5aLkgC3NidkyJGCf-zw6dQ12Yai1rgfVKbkMehsBdadRaWaH0i4lURZvO5vqnVCzfGMzSRgqBQV6xzDv92I095JCGOQbHWw5M51blF4pHE3xs1a4tN-sFBBuceEjkk8nG7VJUnpQzlcCvVxwBgoWGF~pkGbVjwXoY9WYVmQ8n2HPpt6SUkZP7jwp5WgLcIT0s3HCqgcKXjNAxGopXCwZbHAN~e5eiXE-2c1zNbwQGxs0q2xiRC~YidWzG1LdIwK7IzNF0FBTh6SPAU4hY~487QDxsNEzXhPfdjzRg6tbioAFJa5G1HvMAfwcJQwk9KoRugUDuzLSYCg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/60807488/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/60807488/mini_magick20191005-18752-c1dgtq.png?1570299974"}],"downloadable_attachments_with_full_thumbnails":[{"id":60807488,"asset_id":40532921,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/60807488/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/60807488/212_-_Non-syndromic_monogenic_female_infertility20191005-58269-bbm4lj-libre.pdf?1570299979=\u0026response-content-disposition=attachment%3B+filename%3DNon_syndromic_monogenic_female_infertili.pdf\u0026Expires=1732748623\u0026Signature=caXcMCMHTXa5aLkgC3NidkyJGCf-zw6dQ12Yai1rgfVKbkMehsBdadRaWaH0i4lURZvO5vqnVCzfGMzSRgqBQV6xzDv92I095JCGOQbHWw5M51blF4pHE3xs1a4tN-sFBBuceEjkk8nG7VJUnpQzlcCvVxwBgoWGF~pkGbVjwXoY9WYVmQ8n2HPpt6SUkZP7jwp5WgLcIT0s3HCqgcKXjNAxGopXCwZbHAN~e5eiXE-2c1zNbwQGxs0q2xiRC~YidWzG1LdIwK7IzNF0FBTh6SPAU4hY~487QDxsNEzXhPfdjzRg6tbioAFJa5G1HvMAfwcJQwk9KoRugUDuzLSYCg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/60807488/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/60807488/mini_magick20191005-18752-c1dgtq.png?1570299974"}],"has_pdf":true,"has_fulltext":true,"page_count":7,"ordered_authors":[{"id":12242463,"first_name":"Antonio 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and cytogenetics","url":"https://www.academia.edu/Documents/in/Genetics_and_cytogenetics"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"}],"publication_year":2019,"publication_year_with_fallback":2019,"paper_rank":null,"all_time_views":23,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_40851981 coauthored" data-work_id="40851981" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/40851981/Presence_of_Glandular_Cells_at_the_Preoperative_Cervical_Cytology_and_Local_Recurrence_in_Endometrial_Cancer">Presence of Glandular Cells at the Preoperative Cervical Cytology and Local Recurrence in Endometrial Cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We investigated the correlation between glandular cells (GC) detected at preoperative cervical-smear and the histologic findings and oncologic outcomes in patients undergoing surgery for endometrial cancer (EC). We retrospectively... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_40851981" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We investigated the correlation between glandular cells (GC) detected at preoperative cervical-smear and the histologic findings and oncologic outcomes in patients undergoing surgery for endometrial cancer (EC). We retrospectively analyzed data of all consecutive EC patients who underwent surgery between January 1, 1990 and December 31, 2012 with preoperative cervical smear performed within 3 mo from the EC diagnosis. Basic descriptive, logistic regression and artificial neural network analyses were used. Five-year disease-free survival and overall survival were assessed using Kaplan-Meier and Cox hazard models. The study included 229 (89%) and 29 (11%) patients with normal cytology (control group) and GC (GC group), respectively. A higher proportion of elderly patients with nonendometrioid and FIGO grade 3 EC was observed in the GC group compared with the control group (Po0.05). No differences in 5-yr disease-free survival and overall survival were observed. However, patients in the GC group experienced a higher local recurrence rate (hazard ratio: 7.6; 95% confidence interval: 1.7-34.2; P = 0.008). We observed that age, body mass index, cervical stromal invasion, vaginal brachytherapy, and GC influenced the risk for developing local recurrence. However, at the multivariable analysis, only cervical stromal invasion (odds ratio: 1.2; 95% confidence interval: 1.02-1.4; P = 0.02) and GC (odds ratio: 1.07; 95% confidence interval: 1.01-1.14; P = 0.03) correlated with the increased risk. In addition, the results of an artificial neural network analysis reported that the most critical predictor of local failure was cervical stromal invasion (importance: 0.352) followed by GC (importance: 0.194). These results suggest that cervical stromal invasion and presence of GC at the preoperative cervical smear might predict the occurrence of local recurrence in EC.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/40851981" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a8505702826db82fcf6495c1d1fb27c1" rel="nofollow" data-download="{"attachment_id":61137680,"asset_id":40851981,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/61137680/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12242463" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a><script data-card-contents-for-user="12242463" type="text/json">{"id":12242463,"first_name":"Antonio Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-40851981">+1</span><div class="hidden js-additional-users-40851981"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://azospvr.academia.edu/SimoneGarzon">Simone Garzon</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-40851981'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-40851981').html(); 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We retrospectively analyzed data of all consecutive EC patients who underwent surgery between January 1, 1990 and December 31, 2012 with preoperative cervical smear performed within 3 mo from the EC diagnosis. Basic descriptive, logistic regression and artificial neural network analyses were used. Five-year disease-free survival and overall survival were assessed using Kaplan-Meier and Cox hazard models. The study included 229 (89%) and 29 (11%) patients with normal cytology (control group) and GC (GC group), respectively. A higher proportion of elderly patients with nonendometrioid and FIGO grade 3 EC was observed in the GC group compared with the control group (Po0.05). No differences in 5-yr disease-free survival and overall survival were observed. However, patients in the GC group experienced a higher local recurrence rate (hazard ratio: 7.6; 95% confidence interval: 1.7-34.2; P = 0.008). We observed that age, body mass index, cervical stromal invasion, vaginal brachytherapy, and GC influenced the risk for developing local recurrence. However, at the multivariable analysis, only cervical stromal invasion (odds ratio: 1.2; 95% confidence interval: 1.02-1.4; P = 0.02) and GC (odds ratio: 1.07; 95% confidence interval: 1.01-1.14; P = 0.03) correlated with the increased risk. In addition, the results of an artificial neural network analysis reported that the most critical predictor of local failure was cervical stromal invasion (importance: 0.352) followed by GC (importance: 0.194). These results suggest that cervical stromal invasion and presence of GC at the preoperative cervical smear might predict the occurrence of local recurrence in EC.","publication":"Int J Gynecol Pathol.","publication_with_fallback":"Int J Gynecol 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conditions, such as appendicitis, cholecystitis, intestinal occlusion or adnexal mass complications. The early diagnosis and treatment of acute abdomen in pregnant woman... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_42010729" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The 1-2% of pregnant women undergo surgery for pregnancy-unrelated conditions, such as appendicitis, cholecystitis, intestinal occlusion or adnexal mass complications. The early diagnosis and treatment of acute abdomen in pregnant woman are complicated by the physiological and anatomical changes of pregnancy, that make more problematic to recognize early signs of emergent conditions. Moreover, the fear of performing potentially dangerous diagnostic procedures contribute to further delay diagnosis and therapies. In case of acute non-obstetric surgical pathology, conservative management may adversely affect pregnancy outcomes, and surgical intervention should not be deferred only because of the gravid status or the gestational age. Non-obstetric surgery in pregnant patients has been proved to be safe if performed by a team composed by skilled surgeons and obstetricians, and both laparotomic and laparoscopic techniques can be applied if physiological and anatomical changes of pregnancy are considered, and appropriate adjustments are made by the anaesthesiologist. Nevertheless, in many hospital settings there is still a lack of knowledge, and many obstetricians and surgeons are reluctant to practice surgery in pregnant patients, especially laparoscopy. However, the recent available evidence supports non-obstetric surgery's safety and effi cacy, although more data are still needed to make strong recommendations and guidelines.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42010729" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b9851468c4386a1c9a5cd050b66b56c1" rel="nofollow" data-download="{"attachment_id":62135306,"asset_id":42010729,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62135306/download_file?st=MTczMjc0NTAyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12242463" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a><script data-card-contents-for-user="12242463" type="text/json">{"id":12242463,"first_name":"Antonio Simone","last_name":"Laganà","domain_name":"unipa","page_name":"AntonioSimoneLaganà","display_name":"Antonio Simone Laganà","profile_url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","photo":"https://0.academia-photos.com/12242463/3514808/147404315/s65_antonio_simone.lagan_.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-42010729">+1</span><div class="hidden js-additional-users-42010729"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://azospvr.academia.edu/SimoneGarzon">Simone Garzon</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-42010729'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-42010729').html(); 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