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class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Antonio Simone Laganà" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/12242463/3514808/147404315/s200_antonio_simone.lagan_.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Antonio Simone Laganà</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://unipa.academia.edu/">Università degli Studi di Palermo</a>, <a class="u-tcGrayDarker" href="https://unipa.academia.edu/Departments/Unit_of_Obstetrics_and_Gynecology_Paolo_Giaccone_Hospital_Department_of_Health_Promotion_Mother_and_Child_Care_Internal_Medicine_and_Medical_Specialties_PROMISE_/Documents">Unit of Obstetrics and Gynecology, “Paolo Giaccone” Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE)</a>, <span class="u-tcGrayDarker">Faculty Member</span></div><div><a class="u-tcGrayDarker" href="https://unipa.academia.edu/">Università degli Studi di Palermo</a>, <a class="u-tcGrayDarker" href="https://unipa.academia.edu/Departments/Unit_of_Gynecologic_Oncology_ARNAS_Civico_Di_Cristina_Benfratelli_Department_of_Health_Promotion_Mother_and_Child_Care_Internal_Medicine_and_Medical_Specialties_PROMISE_/Documents">Unit of Gynecologic Oncology, ARNAS "Civico – Di Cristina – Benfratelli", Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE)</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" 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class="label">Following</p><p class="data">442</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">131</p></div></a><a href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0/Analytics"><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></a></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Assistant Professor in the Unit of Obstetrics and Gynecology, “Paolo Giaccone” Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo (Palermo, Italy).<br />Antonio Simone Laganà was born in Reggio Calabria (Italy) on 8th May 1986. He is Coordinator of the Special Interest Group for Endometriosis & Endometrial Disorders (SIGEED) of the European Society of Human Reproduction and Embryology (ESHRE). <br />Antonio Simone Laganà was trained in obstetric/gynecological ultrasound at the Altamedica Main Centre in Rome (Italy), got the Master in “Gynecological Minimally Invasive and Robotic Surgery” at the University of Pisa (Italy), the Ph.D. in “Medical and Surgical Biotechnologies” at the University of Messina (Italy), and developed an intensive training in minimally invasive gynecological surgery (high-volume advanced laparoscopy, hysteroscopy) at the Univerzitetni Klinični Center Ljubljana (Slovenia), during the Subspecialist Training Programme (Fellowship) in Reproductive Medicine (according to the criteria of the European Society of Human Reproduction and Embryology, ESHRE, and European Board and College of Gynecology and Obstetrics, EBCOG).<br />His research interests include endometriosis, reproductive immunology, infertility, gynaecological endocrinology, laparoscopy, and hysteroscopy. He is the author of more than 440 papers published in PubMed-indexed international peer-reviewed journals, and his presence is often requested as an invited speaker at international congresses. He is currently an editor of high-impact journals, including Scientific Reports, Journal of Minimally Invasive Gynecology, Journal of Ovarian Research, Gynecologic and Obstetric Investigation, and many others.<br />He is habilitated as Full Professor in Italy for Gynecology and Obstetrics.<br /><b>Address: </b>Messina (Italy)<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="12242463">View All (25)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="12242463" href="https://www.academia.edu/Documents/in/Endometriosis"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","location":"/AntonioSimoneLagan%C3%A0","scheme":"https","host":"unipa.academia.edu","port":null,"pathname":"/AntonioSimoneLagan%C3%A0","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Endometriosis"]}" data-trace="false" data-dom-id="Pill-react-component-896a008a-29f0-4cf7-9c77-09d55082bda9"></div> <div id="Pill-react-component-896a008a-29f0-4cf7-9c77-09d55082bda9"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="12242463" href="https://www.academia.edu/Documents/in/Immunogenetics_and_Reproductive_Immunology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Immunogenetics and Reproductive Immunology"]}" data-trace="false" data-dom-id="Pill-react-component-7230c6d0-955a-4d39-91fb-95cd5fb566f9"></div> <div id="Pill-react-component-7230c6d0-955a-4d39-91fb-95cd5fb566f9"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="12242463" href="https://www.academia.edu/Documents/in/Reproductive_Immunology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Reproductive Immunology"]}" data-trace="false" data-dom-id="Pill-react-component-3b6e2d17-a018-4327-a0ef-7616e8afbb06"></div> <div id="Pill-react-component-3b6e2d17-a018-4327-a0ef-7616e8afbb06"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="12242463" href="https://www.academia.edu/Documents/in/T_Cell_biology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["T Cell biology"]}" data-trace="false" data-dom-id="Pill-react-component-ef59984c-1798-462b-bd27-5a7b665ca4fe"></div> <div id="Pill-react-component-ef59984c-1798-462b-bd27-5a7b665ca4fe"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="12242463" href="https://www.academia.edu/Documents/in/T_cells"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["T cells"]}" data-trace="false" data-dom-id="Pill-react-component-8d5417da-553d-4b07-8b72-3ea6f47b92c7"></div> <div id="Pill-react-component-8d5417da-553d-4b07-8b72-3ea6f47b92c7"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li class="left-most js-UserInfo-social-cv" data-broccoli-component="user-info.cv-button" data-click-track="profile-user-info-cv" data-cv-filename="Antonio_Simone_Lagana_CV.pdf" data-placement="top" data-toggle="tooltip" href="/AntonioSimoneLagan%C3%A0/CurriculumVitae"><button class="ds2-5-text-link ds2-5-text-link--small" style="font-size: 20px; 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Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the literature.<br />Case presentation. We reported clinical, diagnostic and therapeutical choices of a 44-year aged patient with a rare abnormally sized vulvar lipoma. A Diamond-shaped skin incision was performed and the neoformation was removed without capsule lesions. A vaginal plastic skin-reducing was performed to reduce redundant tissue. The deep planes of the lesion have been reconstructed to avoid leakage.<br />Conclusions. This kind of lipomas can be potentially diagnosed through clinical examination because of their specific characteristics. However, imaging is advisable to differentiate benign neoplasm from malignant one. Different approaches can be achieved for lipomas based on the size of lump, patient’s feelings and necessities and the operation goals; however, the complete surgical excision with the removal of capsules to prevent recurrence remains the treatment of choice for vulvar lipomas. Different surgical approaches aim to achieve better esthetical results, less scarring, and less colour discordance of the connected tissues post-surgery. Surgery is the gold standard for treatment of vulvar lesions. Currently, there is no evidence of long-term follow-up in the literature. We recommend an adequate counselling with the patient to understand their needs and encouraging them to seek medical advice and to tailor the treatment of such lesions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="377330743865e2ea764d63b709a68821" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117874429,"asset_id":123445950,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117874429/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123445950"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123445950"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123445950; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123445950]").text(description); $(".js-view-count[data-work-id=123445950]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123445950; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123445950']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123445950, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "377330743865e2ea764d63b709a68821" } } $('.js-work-strip[data-work-id=123445950]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123445950,"title":"Vulvar lipoma: rare case, rare location","translated_title":"","metadata":{"doi":"10.36129/jog.2023.134","abstract":"Background. Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the literature.\nCase presentation. We reported clinical, diagnostic and therapeutical choices of a 44-year aged patient with a rare abnormally sized vulvar lipoma. A Diamond-shaped skin incision was performed and the neoformation was removed without capsule lesions. A vaginal plastic skin-reducing was performed to reduce redundant tissue. The deep planes of the lesion have been reconstructed to avoid leakage.\nConclusions. This kind of lipomas can be potentially diagnosed through clinical examination because of their specific characteristics. However, imaging is advisable to differentiate benign neoplasm from malignant one. Different approaches can be achieved for lipomas based on the size of lump, patient’s feelings and necessities and the operation goals; however, the complete surgical excision with the removal of capsules to prevent recurrence remains the treatment of choice for vulvar lipomas. Different surgical approaches aim to achieve better esthetical results, less scarring, and less colour discordance of the connected tissues post-surgery. Surgery is the gold standard for treatment of vulvar lesions. Currently, there is no evidence of long-term follow-up in the literature. We recommend an adequate counselling with the patient to understand their needs and encouraging them to seek medical advice and to tailor the treatment of such lesions.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Italian Journal of Gynæcology \u0026 Obstetrics"},"translated_abstract":"Background. Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the literature.\nCase presentation. We reported clinical, diagnostic and therapeutical choices of a 44-year aged patient with a rare abnormally sized vulvar lipoma. A Diamond-shaped skin incision was performed and the neoformation was removed without capsule lesions. A vaginal plastic skin-reducing was performed to reduce redundant tissue. The deep planes of the lesion have been reconstructed to avoid leakage.\nConclusions. This kind of lipomas can be potentially diagnosed through clinical examination because of their specific characteristics. However, imaging is advisable to differentiate benign neoplasm from malignant one. Different approaches can be achieved for lipomas based on the size of lump, patient’s feelings and necessities and the operation goals; however, the complete surgical excision with the removal of capsules to prevent recurrence remains the treatment of choice for vulvar lipomas. Different surgical approaches aim to achieve better esthetical results, less scarring, and less colour discordance of the connected tissues post-surgery. Surgery is the gold standard for treatment of vulvar lesions. Currently, there is no evidence of long-term follow-up in the literature. We recommend an adequate counselling with the patient to understand their needs and encouraging them to seek medical advice and to tailor the treatment of such lesions.","internal_url":"https://www.academia.edu/123445950/Vulvar_lipoma_rare_case_rare_location","translated_internal_url":"","created_at":"2024-09-01T09:45:03.752-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":117874429,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117874429/thumbnails/1.jpg","file_name":"570_Vulvar_Lipoma._Rare_case_rare_location.pdf","download_url":"https://www.academia.edu/attachments/117874429/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_lipoma_rare_case_rare_location.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117874429/570_Vulvar_Lipoma._Rare_case_rare_location-libre.pdf?1725211054=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_lipoma_rare_case_rare_location.pdf\u0026Expires=1732736057\u0026Signature=V4eOi8bzLKxXlYoPKvN3TLhGe5mbR5jlB4nfhr0kWxxIiA3200dnTdYx2BQ27FeS136~jEiUyAyS5W3pob~um51I0bLlt8JRaCwUBbgkbGjVeyvmAZioApHsFo6ayjmH4QLWqcYiqHjbUHUVGi0~3POFVL7gZKwakFAFCMiyX0jcibv~B94bd1W~DBQrA~DSOWpFa3yratHA-ZDc3OF2vVgaRrM~YCycQW2vdze4S1XmoA2BL8nKOz479plczfsq1-51AwDl9iSF2UKGUPsS74NPq9h6~9Bl5jbGmtsBh2bkvh-dzX0ec9gEUu~tMbq2KdFzkks2ucif6Hvlg8GXCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Vulvar_lipoma_rare_case_rare_location","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"TmV6dUUrSWpNUEIwU0JIS2NycXBMVzVxZmpxd01mN0hQVmJKZzRSc3h2Zz0tLU5WcDlGdCtrdlRRa1loUzZnL2g3eWc9PQ==--8e39d3f60d2104fe22883a3cdf46500cd9114424"},"attachments":[{"id":117874429,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117874429/thumbnails/1.jpg","file_name":"570_Vulvar_Lipoma._Rare_case_rare_location.pdf","download_url":"https://www.academia.edu/attachments/117874429/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_lipoma_rare_case_rare_location.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117874429/570_Vulvar_Lipoma._Rare_case_rare_location-libre.pdf?1725211054=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_lipoma_rare_case_rare_location.pdf\u0026Expires=1732736057\u0026Signature=V4eOi8bzLKxXlYoPKvN3TLhGe5mbR5jlB4nfhr0kWxxIiA3200dnTdYx2BQ27FeS136~jEiUyAyS5W3pob~um51I0bLlt8JRaCwUBbgkbGjVeyvmAZioApHsFo6ayjmH4QLWqcYiqHjbUHUVGi0~3POFVL7gZKwakFAFCMiyX0jcibv~B94bd1W~DBQrA~DSOWpFa3yratHA-ZDc3OF2vVgaRrM~YCycQW2vdze4S1XmoA2BL8nKOz479plczfsq1-51AwDl9iSF2UKGUPsS74NPq9h6~9Bl5jbGmtsBh2bkvh-dzX0ec9gEUu~tMbq2KdFzkks2ucif6Hvlg8GXCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":618,"name":"Gynaecology","url":"https://www.academia.edu/Documents/in/Gynaecology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"},{"id":1584584,"name":"Obgyn and Gynecology","url":"https://www.academia.edu/Documents/in/Obgyn_and_Gynecology"},{"id":1789935,"name":"Ob/gyn","url":"https://www.academia.edu/Documents/in/Ob_gyn-1"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122867561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122867561/Silent_spontaneous_uterine_rupture_in_a_term_pregnancy_with_extrusion_of_an_intact_amniotic_sac_and_without_maternal_and_neonatal_morbidity_and_mortality"><img alt="Research paper thumbnail of Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and mortality" class="work-thumbnail" src="https://attachments.academia-assets.com/117439334/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122867561/Silent_spontaneous_uterine_rupture_in_a_term_pregnancy_with_extrusion_of_an_intact_amniotic_sac_and_without_maternal_and_neonatal_morbidity_and_mortality">Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and mortality</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/SorrentinoFelice">Felice Sorrentino</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FeliceSorrentino2">Felice Sorrentino</a></span></div><div class="wp-workCard_item"><span>Italian Journal of Gynæcology & Obstetrics</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Uterine rupture in pregnancy is a rare and catastrophic complication with a high inci...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Uterine rupture in pregnancy is a rare and catastrophic complication with a high incidence of fetal and maternal morbidity and mortality. Silent spontaneous uterine rupture without maternal or neonatal morbidity or mortality is very rare.<br />Case presentation. We describe a case of silent spontaneous uterine rupture diagnosed during a planned cesarean section in a patient at 38+4 weeks’ gestation with two previous cesarean sections. The mother and newborn were discharged three days later in good health and without complications.<br />Conclusions. Worldwide, the frequency of cesarean deliveries has increased in recent decades and uterine rupture is a very rare catastrophic emergency that can have dramatic consequences. Our case report shows that uterine rupture can occur in pregnancy before labour without any signs or symptoms. Despite the uterine rupture with extrusion of the intact amniotic sac, there were no complications for the mother or the foetus. Timely diagnosis is crucial and future research should find more reproducible parameters to objectify the risk of silent uterine rupture and define the timing of delivery of previous cesarean sections requiring a new surgical delivery. All patients with previous cesarean sections should be counselled about the possibility of early delivery by cesarean section.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7fcec18aa9933dec5b30fdcdc240b4dd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117439334,"asset_id":122867561,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117439334/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122867561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122867561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122867561; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122867561]").text(description); $(".js-view-count[data-work-id=122867561]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122867561; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122867561']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122867561, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7fcec18aa9933dec5b30fdcdc240b4dd" } } $('.js-work-strip[data-work-id=122867561]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122867561,"title":"Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and mortality","translated_title":"","metadata":{"doi":"10.36129/jog.2024.153","abstract":"Background. Uterine rupture in pregnancy is a rare and catastrophic complication with a high incidence of fetal and maternal morbidity and mortality. Silent spontaneous uterine rupture without maternal or neonatal morbidity or mortality is very rare.\nCase presentation. We describe a case of silent spontaneous uterine rupture diagnosed during a planned cesarean section in a patient at 38+4 weeks’ gestation with two previous cesarean sections. The mother and newborn were discharged three days later in good health and without complications.\nConclusions. Worldwide, the frequency of cesarean deliveries has increased in recent decades and uterine rupture is a very rare catastrophic emergency that can have dramatic consequences. Our case report shows that uterine rupture can occur in pregnancy before labour without any signs or symptoms. Despite the uterine rupture with extrusion of the intact amniotic sac, there were no complications for the mother or the foetus. Timely diagnosis is crucial and future research should find more reproducible parameters to objectify the risk of silent uterine rupture and define the timing of delivery of previous cesarean sections requiring a new surgical delivery. All patients with previous cesarean sections should be counselled about the possibility of early delivery by cesarean section.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Italian Journal of Gynæcology \u0026 Obstetrics"},"translated_abstract":"Background. Uterine rupture in pregnancy is a rare and catastrophic complication with a high incidence of fetal and maternal morbidity and mortality. Silent spontaneous uterine rupture without maternal or neonatal morbidity or mortality is very rare.\nCase presentation. We describe a case of silent spontaneous uterine rupture diagnosed during a planned cesarean section in a patient at 38+4 weeks’ gestation with two previous cesarean sections. The mother and newborn were discharged three days later in good health and without complications.\nConclusions. Worldwide, the frequency of cesarean deliveries has increased in recent decades and uterine rupture is a very rare catastrophic emergency that can have dramatic consequences. Our case report shows that uterine rupture can occur in pregnancy before labour without any signs or symptoms. Despite the uterine rupture with extrusion of the intact amniotic sac, there were no complications for the mother or the foetus. Timely diagnosis is crucial and future research should find more reproducible parameters to objectify the risk of silent uterine rupture and define the timing of delivery of previous cesarean sections requiring a new surgical delivery. All patients with previous cesarean sections should be counselled about the possibility of early delivery by cesarean section.","internal_url":"https://www.academia.edu/122867561/Silent_spontaneous_uterine_rupture_in_a_term_pregnancy_with_extrusion_of_an_intact_amniotic_sac_and_without_maternal_and_neonatal_morbidity_and_mortality","translated_internal_url":"","created_at":"2024-08-14T03:19:51.338-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42223258,"work_id":122867561,"tagging_user_id":12242463,"tagged_user_id":300691524,"co_author_invite_id":null,"email":"f***3@gmail.com","display_order":1,"name":"Felice Sorrentino","title":"Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122844338/When_one_size_does_not_fit_all_Reconsidering_PCOS_etiology_diagnosis_clinical_subgroups_and_subgroup_specific_treatments"><img alt="Research paper thumbnail of When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments" class="work-thumbnail" src="https://attachments.academia-assets.com/117422033/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122844338/When_one_size_does_not_fit_all_Reconsidering_PCOS_etiology_diagnosis_clinical_subgroups_and_subgroup_specific_treatments">When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments</a></div><div class="wp-workCard_item"><span>Endocrine and Metabolic Science</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion of women. Due to its heterogeneity, the best diagnostic strategy has been a matter of contention. Since 1990 scientific societies in the field of human reproduction have tried to define the pivotal criteria for the diagnosis of PCOS. The consensus Rotterdam diagnostic criteria included the presence of hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology (PCOM), and have now been updated to evidence based diagnostic criteria in the 2018 and 2023 International Guideline diagnostic criteria endorsed by 39 societies internationally. Within the Rotterdam Criteria, at least two out of three of the above-mentioned features are required to be present to diagnose PCOS, resulting in four phenotypes being identified: phenotype A, characterized by the presence of all the features, phenotype B, exhibiting hyperandrogenism and oligo-anovulation, phenotype C, presenting as hyperandrogenism and PCOM and finally the phenotype D that is characterized by oligo-anovulation and PCOM, lacking the hyperandrogenic component. However, it is the hypothesis of the EGOI group that the Rotterdam phenotypes A, B, and C have a different underlying causality to phenotype D. Recent studies have highlighted the strong correlation between insulin resistance and hyperandrogenism, and the pivotal role of these factors in driving ovarian alterations, such as oligo-anovulation and follicular functional cyst formation. This new understanding of PCOS pathogenesis has led the authors to hypothesis that phenotypes A, B, and C are endocrine-metabolic syndromes with a metabolic clinical onset. Conversely, the absence of hyperandrogenism and metabolic disturbances in phenotype D suggests a different origin of this condition, and point towards novel pathophysiological mechanisms; however, these are still not fully understood. Further questions have been raised regarding the suitability of the “phenotypes” described by the Rotterdam Criteria by the publication by recent GWAS studies, which demonstrated that these phenotypes should be considered clinical subtypes as they are not reflected in the genetic picture. Hence, by capturing the heterogeneity of this complex disorder, current diagnostic criteria may benefit from a reassessment and the evaluation of additional parameters such as insulin resistance and endometrial thickness, with the purpose of not only improving their diagnostic accuracy but also of assigning an appropriate and personalized treatment. In this framework, the present overview aims to analyze the diagnostic criteria currently recognized by the scientific community and assess the suitability of their application in clinical practice in light of the newly emerging evidence.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="13b44d6210a559a0791ed516a0616ead" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117422033,"asset_id":122844338,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117422033/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122844338"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122844338"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122844338; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122844338]").text(description); $(".js-view-count[data-work-id=122844338]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122844338; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122844338']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122844338, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "13b44d6210a559a0791ed516a0616ead" } } $('.js-work-strip[data-work-id=122844338]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122844338,"title":"When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments","translated_title":"","metadata":{"doi":"10.1016/j.endmts.2024.100159","abstract":"Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion of women. 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122808467"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122808467/The_importance_of_a_multidisciplinary_approach_in_the_treatment_of_uterine_fibroids"><img alt="Research paper thumbnail of The importance of a multidisciplinary approach in the treatment of uterine fibroids" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122808467/The_importance_of_a_multidisciplinary_approach_in_the_treatment_of_uterine_fibroids">The importance of a multidisciplinary approach in the treatment of uterine fibroids</a></div><div class="wp-workCard_item"><span>Gazzetta Medica Italiana Archivio per le Scienze Mediche</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122808467"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122808467"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122808467; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122711902/Hormonal_Therapies_before_in_vitro_fertilization_in_women_with_endometriosis_The_Minotaurs_Labyrinth_and_the_Ariadnes_Thread"><img alt="Research paper thumbnail of Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122711902/Hormonal_Therapies_before_in_vitro_fertilization_in_women_with_endometriosis_The_Minotaurs_Labyrinth_and_the_Ariadnes_Thread">Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread</a></div><div class="wp-workCard_item"><span>Best Practice & Research Clinical Obstetrics & Gynaecology</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In recent years, prolonged pre-cycle hormonal regimens gained attention as a mean of improving the assisted reproduction technologies (ART) success rates in endometriosis patients. GnRH agonists, dienogest, medroxyprogesterone acetate, and aromatase inhibitors are the most studied medications. Conflicting results and a high risk of bias exist in almost all of the conducted studies in the field. However, current evidence suggests that pre-cycle treatment with GnRH agonists may be beneficial for patients with stage III/IV endometriosis. Dienogest and medroxyprogesterone acetate-based progestin-primed ovarian stimulation protocol was shown to be comparable to the prolonged GnRH agonists protocol. Finally, aromatase inhibitors seem to be of limited benefit to the assisted reproductive outcomes of endometriosis patients. Although it is challenging to draw any clinical conclusions, pre-cycle hormonal treatments seem to be best indicated in endometriosis patients who had previously failed ART treatment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122711902"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122711902"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122711902; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122711902]").text(description); $(".js-view-count[data-work-id=122711902]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122711902; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122711902']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122711902, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122711902]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122711902,"title":"Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread","translated_title":"","metadata":{"doi":"10.1016/j.bpobgyn.2024.102500","abstract":"Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In recent years, prolonged pre-cycle hormonal regimens gained attention as a mean of improving the assisted reproduction technologies (ART) success rates in endometriosis patients. GnRH agonists, dienogest, medroxyprogesterone acetate, and aromatase inhibitors are the most studied medications. Conflicting results and a high risk of bias exist in almost all of the conducted studies in the field. However, current evidence suggests that pre-cycle treatment with GnRH agonists may be beneficial for patients with stage III/IV endometriosis. Dienogest and medroxyprogesterone acetate-based progestin-primed ovarian stimulation protocol was shown to be comparable to the prolonged GnRH agonists protocol. Finally, aromatase inhibitors seem to be of limited benefit to the assisted reproductive outcomes of endometriosis patients. Although it is challenging to draw any clinical conclusions, pre-cycle hormonal treatments seem to be best indicated in endometriosis patients who had previously failed ART treatment.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Best Practice \u0026 Research Clinical Obstetrics \u0026 Gynaecology"},"translated_abstract":"Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In recent years, prolonged pre-cycle hormonal regimens gained attention as a mean of improving the assisted reproduction technologies (ART) success rates in endometriosis patients. GnRH agonists, dienogest, medroxyprogesterone acetate, and aromatase inhibitors are the most studied medications. Conflicting results and a high risk of bias exist in almost all of the conducted studies in the field. However, current evidence suggests that pre-cycle treatment with GnRH agonists may be beneficial for patients with stage III/IV endometriosis. Dienogest and medroxyprogesterone acetate-based progestin-primed ovarian stimulation protocol was shown to be comparable to the prolonged GnRH agonists protocol. Finally, aromatase inhibitors seem to be of limited benefit to the assisted reproductive outcomes of endometriosis patients. 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Alth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Endometriosis means the presence of tissue similar to normal endometrium outside the uterus. Although surgical, hormonal, and analgesic treatment relieves symptoms and improves fertility, it is associated with side effects and a high recurrence rate. Alternative medicines like medicinal plants have been used for the treatment of chronic diseases. Given the global importance of endometriosis as a chronic disease affecting over 15% of all women in their fertile period, this systematic review aimed to give a comprehensive view of research on medicinal plants. MATERIALS AND METHODS: Comprehensive searches were performed on three databases, including PubMed/MEDLINE, Web of Science Core Collection (Indexes = SCI-EXPANDED, SS-CI, A, and HCI Timespan), and Scopus, to identify papers published until June 2023. Keywords, such as "Endometriosis" and "Herbal Medicine", were used to search. A manual search of valid journals followed by a manual search of the references of the retrieved full-text articles was performed. All retrieved articles were imported into a database into Endnote X9. Articles that did not meet the inclusion criteria were excluded from the study, and the full texts of all the articles that met the inclusion criteria were assessed. Studies that evaluated the effects of herbal compounds on various aspects of endometriosis treatment were included in the review. RESULTS: In total, 11 studies were included in the present study. The evidence showed that in addition to safety, drugs available alongside treatments could play an effective role in improving the symptoms associated with endometriosis. In this study, the positive results of using Chinese treatments were reported in aspects such as fertility rate, pain, endometriosis recurrence rate, quality of life, sexual function, CA-125 level, and menopause symptoms. CONCLUSIONS: A wide range of preclinical and clinical studies evaluated the effectiveness and safety of medicinal plants in the treatment of endometriosis symptoms. Thus, alternative treatments for endometriosis with no or low side effects should be included in the holistic treatment of endometriosis upfront. However, there is still a need for well-designed trials to investigate standard interventions and specific and safe doses of herbal medicines.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ce6b3bb1338f1be28ea3ec8e992f262c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117178102,"asset_id":122535283,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117178102/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122535283"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122535283"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122535283; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122535283]").text(description); $(".js-view-count[data-work-id=122535283]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122535283; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122535283']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122535283, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ce6b3bb1338f1be28ea3ec8e992f262c" } } $('.js-work-strip[data-work-id=122535283]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122535283,"title":"Effects of herbal compounds on various aspects of endometriosis treatment: a systematic review","translated_title":"","metadata":{"doi":"10.26355/eurrev_202405_36182","abstract":"Endometriosis means the presence of tissue similar to normal endometrium outside the uterus. Although surgical, hormonal, and analgesic treatment relieves symptoms and improves fertility, it is associated with side effects and a high recurrence rate. Alternative medicines like medicinal plants have been used for the treatment of chronic diseases. Given the global importance of endometriosis as a chronic disease affecting over 15% of all women in their fertile period, this systematic review aimed to give a comprehensive view of research on medicinal plants. MATERIALS AND METHODS: Comprehensive searches were performed on three databases, including PubMed/MEDLINE, Web of Science Core Collection (Indexes = SCI-EXPANDED, SS-CI, A, and HCI Timespan), and Scopus, to identify papers published until June 2023. Keywords, such as \"Endometriosis\" and \"Herbal Medicine\", were used to search. A manual search of valid journals followed by a manual search of the references of the retrieved full-text articles was performed. 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Thus, alternative treatments for endometriosis with no or low side effects should be included in the holistic treatment of endometriosis upfront. However, there is still a need for well-designed trials to investigate standard interventions and specific and safe doses of herbal medicines.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"European Review for Medical and Pharmacological Sciences"},"translated_abstract":"Endometriosis means the presence of tissue similar to normal endometrium outside the uterus. Although surgical, hormonal, and analgesic treatment relieves symptoms and improves fertility, it is associated with side effects and a high recurrence rate. Alternative medicines like medicinal plants have been used for the treatment of chronic diseases. 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Studies that evaluated the effects of herbal compounds on various aspects of endometriosis treatment were included in the review. RESULTS: In total, 11 studies were included in the present study. The evidence showed that in addition to safety, drugs available alongside treatments could play an effective role in improving the symptoms associated with endometriosis. In this study, the positive results of using Chinese treatments were reported in aspects such as fertility rate, pain, endometriosis recurrence rate, quality of life, sexual function, CA-125 level, and menopause symptoms. CONCLUSIONS: A wide range of preclinical and clinical studies evaluated the effectiveness and safety of medicinal plants in the treatment of endometriosis symptoms. Thus, alternative treatments for endometriosis with no or low side effects should be included in the holistic treatment of endometriosis upfront. However, there is still a need for well-designed trials to investigate standard interventions and specific and safe doses of herbal medicines.","internal_url":"https://www.academia.edu/122535283/Effects_of_herbal_compounds_on_various_aspects_of_endometriosis_treatment_a_systematic_review","translated_internal_url":"","created_at":"2024-08-02T09:43:25.675-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42157303,"work_id":122535283,"tagging_user_id":12242463,"tagged_user_id":null,"co_author_invite_id":5804907,"email":"a***a@hotmail.com","display_order":1,"name":"A. Laganà","title":"Effects of herbal compounds on various aspects of endometriosis treatment: a systematic review"},{"id":42157304,"work_id":122535283,"tagging_user_id":12242463,"tagged_user_id":139424579,"co_author_invite_id":null,"email":"i***t@uksh.de","display_order":2,"name":"I. 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href="https://www.academia.edu/122466389/Editorial_Early_cervical_cancer_laparotomic_vs_minimally_invasive_surgery_and_fertility_sparing_possible_strategies">Editorial: Early cervical cancer: laparotomic vs minimally invasive surgery and fertility-sparing possible strategies</a></div><div class="wp-workCard_item"><span>Frontiers in Medicine</span><span>, 2024</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fa7924eb682168300d61bd01a3ac4161" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117124063,"asset_id":122466389,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117124063/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: 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and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413312"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413312/Long_term_therapy_with_dienogest_or_other_oral_cyclic_estrogen_progestogen_can_reduce_the_need_for_ovarian_endometrioma_surgery"><img alt="Research paper thumbnail of Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma surgery" class="work-thumbnail" src="https://attachments.academia-assets.com/117081017/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413312/Long_term_therapy_with_dienogest_or_other_oral_cyclic_estrogen_progestogen_can_reduce_the_need_for_ovarian_endometrioma_surgery">Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma surgery</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MatteoEpis">Matteo Epis</a></span></div><div class="wp-workCard_item"><span>Womens Health (Lond)</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Almost 10% of women in reproductive age are diagnosed with ovarian endometriomas and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Almost 10% of women in reproductive age are diagnosed with ovarian endometriomas and can experience symptoms and infertility disorders. Ovarian endometriomas can be treated with medical or surgical therapy. Objective: To assess whether long-term therapy with dienogest or oral cyclic estrogen-progestogens is effective in reducing the size of ovarian endometriomas, alleviating associated symptoms, and reducing the requirement for surgery. Design: Prospective non-interventional cohort study. Methods: We enrolled childbearing women diagnosed with ovarian endometriomas. We collected demographic, clinical, and surgical data, including the evaluation of ovarian endometrioma-associated symptoms and pain using the visual analog scale. We grouped the women according to treatment regimen into dienogest, estrogen-progestogens, and no-treatment. Patient's assessment was performed at baseline and after 12 months evaluating the largest ovarian endometrioma diameter (in millimeters) and the associated symptoms. Furthermore, we analyzed the impact of hormonal treatment in a subgroup of women fulfilling at baseline the criteria for a first-line surgical approach (ovarian endometrioma > 30 mm with visual analog scale > 8 or ovarian endometrioma > 40 mm before assisted reproductive treatments or any ovarian endometrioma(s) > 60 mm). Results: We enrolled 142 patients: 62, 38, and 42 in dienogest, estrogen-progestogens, and no-treatment groups, respectively. No significant differences were found regarding baseline characteristics. After 12 months, the mean largest ovarian endometrioma diameter increased in the no-treatment group (31.1 versus 33.8; p < 0.01), while a significant reduction was registered in the dienogest (35.1 versus 25.8; p < 0.01) and estrogen-progestogens (28.4 versus 16.7; p < 0.01) groups; no significant difference in ovarian endometrioma diameter reduction between these two latter groups was noted (p = 0.18). Ovarian endometrioma-associated symptoms and pain improved in dienogest and estrogenprogestogens groups, with a significantly greater effect for dienogest than for estrogen-progestogens for dysmenorrhea (74% versus 59%; p < 0.01). In the subgroup of women eligible for first-line surgery at baseline, long-term treatment with dienogest and estrogen-progestogens reduced surgical eligibility by 30%.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="75047536bba04a20f48f404ed16124c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117081017,"asset_id":122413312,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117081017/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413312"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413312"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413312; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413312]").text(description); $(".js-view-count[data-work-id=122413312]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413312; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413312']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122413312, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "75047536bba04a20f48f404ed16124c3" } } $('.js-work-strip[data-work-id=122413312]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413312,"title":"Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma surgery","translated_title":"","metadata":{"doi":"10.1177/17455057241252573","abstract":"Background: Almost 10% of women in reproductive age are diagnosed with ovarian endometriomas and can experience symptoms and infertility disorders. Ovarian endometriomas can be treated with medical or surgical therapy. Objective: To assess whether long-term therapy with dienogest or oral cyclic estrogen-progestogens is effective in reducing the size of ovarian endometriomas, alleviating associated symptoms, and reducing the requirement for surgery. Design: Prospective non-interventional cohort study. Methods: We enrolled childbearing women diagnosed with ovarian endometriomas. We collected demographic, clinical, and surgical data, including the evaluation of ovarian endometrioma-associated symptoms and pain using the visual analog scale. We grouped the women according to treatment regimen into dienogest, estrogen-progestogens, and no-treatment. Patient's assessment was performed at baseline and after 12 months evaluating the largest ovarian endometrioma diameter (in millimeters) and the associated symptoms. Furthermore, we analyzed the impact of hormonal treatment in a subgroup of women fulfilling at baseline the criteria for a first-line surgical approach (ovarian endometrioma \u003e 30 mm with visual analog scale \u003e 8 or ovarian endometrioma \u003e 40 mm before assisted reproductive treatments or any ovarian endometrioma(s) \u003e 60 mm). Results: We enrolled 142 patients: 62, 38, and 42 in dienogest, estrogen-progestogens, and no-treatment groups, respectively. No significant differences were found regarding baseline characteristics. After 12 months, the mean largest ovarian endometrioma diameter increased in the no-treatment group (31.1 versus 33.8; p \u003c 0.01), while a significant reduction was registered in the dienogest (35.1 versus 25.8; p \u003c 0.01) and estrogen-progestogens (28.4 versus 16.7; p \u003c 0.01) groups; no significant difference in ovarian endometrioma diameter reduction between these two latter groups was noted (p = 0.18). Ovarian endometrioma-associated symptoms and pain improved in dienogest and estrogenprogestogens groups, with a significantly greater effect for dienogest than for estrogen-progestogens for dysmenorrhea (74% versus 59%; p \u003c 0.01). In the subgroup of women eligible for first-line surgery at baseline, long-term treatment with dienogest and estrogen-progestogens reduced surgical eligibility by 30%.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Womens Health (Lond)"},"translated_abstract":"Background: Almost 10% of women in reproductive age are diagnosed with ovarian endometriomas and can experience symptoms and infertility disorders. Ovarian endometriomas can be treated with medical or surgical therapy. Objective: To assess whether long-term therapy with dienogest or oral cyclic estrogen-progestogens is effective in reducing the size of ovarian endometriomas, alleviating associated symptoms, and reducing the requirement for surgery. Design: Prospective non-interventional cohort study. Methods: We enrolled childbearing women diagnosed with ovarian endometriomas. We collected demographic, clinical, and surgical data, including the evaluation of ovarian endometrioma-associated symptoms and pain using the visual analog scale. We grouped the women according to treatment regimen into dienogest, estrogen-progestogens, and no-treatment. Patient's assessment was performed at baseline and after 12 months evaluating the largest ovarian endometrioma diameter (in millimeters) and the associated symptoms. Furthermore, we analyzed the impact of hormonal treatment in a subgroup of women fulfilling at baseline the criteria for a first-line surgical approach (ovarian endometrioma \u003e 30 mm with visual analog scale \u003e 8 or ovarian endometrioma \u003e 40 mm before assisted reproductive treatments or any ovarian endometrioma(s) \u003e 60 mm). Results: We enrolled 142 patients: 62, 38, and 42 in dienogest, estrogen-progestogens, and no-treatment groups, respectively. No significant differences were found regarding baseline characteristics. After 12 months, the mean largest ovarian endometrioma diameter increased in the no-treatment group (31.1 versus 33.8; p \u003c 0.01), while a significant reduction was registered in the dienogest (35.1 versus 25.8; p \u003c 0.01) and estrogen-progestogens (28.4 versus 16.7; p \u003c 0.01) groups; no significant difference in ovarian endometrioma diameter reduction between these two latter groups was noted (p = 0.18). Ovarian endometrioma-associated symptoms and pain improved in dienogest and estrogenprogestogens groups, with a significantly greater effect for dienogest than for estrogen-progestogens for dysmenorrhea (74% versus 59%; p \u003c 0.01). In the subgroup of women eligible for first-line surgery at baseline, long-term treatment with dienogest and estrogen-progestogens reduced surgical eligibility by 30%.","internal_url":"https://www.academia.edu/122413312/Long_term_therapy_with_dienogest_or_other_oral_cyclic_estrogen_progestogen_can_reduce_the_need_for_ovarian_endometrioma_surgery","translated_internal_url":"","created_at":"2024-07-28T09:33:08.208-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42125814,"work_id":122413312,"tagging_user_id":12242463,"tagged_user_id":272341019,"co_author_invite_id":null,"email":"f***i@unibs.it","display_order":1,"name":"Federi Ferrari","title":"Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma 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"profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122353682"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122353682/Coexistence_of_Endometriosis_and_Thyroid_Autoimmunity_in_Infertile_Women_Impact_on_in_vitro_Fertilization_and_Reproductive_Outcomes"><img alt="Research paper thumbnail of Coexistence of Endometriosis and Thyroid Autoimmunity in Infertile Women: Impact on in vitro Fertilization and Reproductive Outcomes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122353682/Coexistence_of_Endometriosis_and_Thyroid_Autoimmunity_in_Infertile_Women_Impact_on_in_vitro_Fertilization_and_Reproductive_Outcomes">Coexistence of Endometriosis and Thyroid Autoimmunity in Infertile Women: Impact on in vitro Fertilization and Reproductive Outcomes</a></div><div class="wp-workCard_item"><span>Gynecologic and Obstetric Investigation</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: The objective of the study was to evaluate the prevalence and impact of impaired thyr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: The objective of the study was to evaluate the prevalence and impact of impaired thyroid-stimulating hormone (TSH) levels on the reproductive outcomes of in vitro fertilization patients diagnosed with endometriosis and compared to controls without endometriosis.<br /><br />Design: This is a retrospective cohort study on prospectively collected data.<br /><br />Setting: The study was conducted at tertiary care university hospital.<br /><br />Participants: Participants were infertile women with histopathological diagnosis of endometriosis.<br /><br />Methods: For 12 months (January 2018 to January 2019), women were deemed suitable and subsequently divided according to serum TSH levels above or below 2.5 mIU/L and compared to patients without endometriosis. Needed sample size was at least 41 patients for each cohort of women. Co-primary outcomes were the live birth rate (LBR), clinical pregnancy rate (CPR), and pregnancy loss rate (PLR).<br /><br />Results: Overall, 226 women (45 with endometriosis and 181 controls without endometriosis) were included. Diagnoses of Hashimoto thyroiditis were significantly more frequent in women with rather than without endometriosis (14/45 [31.1%] vs. 27/181 [14.9%]; p = 0.012). Similarly, in women with endometriosis, Hashimoto diagnosis rates were higher with TSH ≥2.5 mIU/L compared to TSH &lt;2.5 mIU/L (9/15 [60%] vs.5/30 [16.6%]; p = 0.001) so were the Hashimoto diagnosis rates in control group (women without endometriosis) with TSH ≥2.5 mIU/L compared to TSH &lt;2.5 mIU/L (17/48 [35.4%] vs. 10/133 [7.5%], respectively; p = 0.001). Effect size analysis confirmed an increased risk of Hashimoto thyroiditis in women with endometriosis and TSH ≥2.5 mIU/L compared to women with endometriosis and TSH &lt;2.5 mIU/L (risk ratio [RR] 3.60 [95% CI 1.46-8.86]) and in women with endometriosis and TSH ≥2.5 mIU/L compared to non-endometriotic euthyroid patients (RR 7.98 [95% CI 3.86-16.48]). Dysmenorrhea risk was higher in endometriotic euthyroid women compared to euthyroid patients with no endometriosis (RR 1.87 [95% CI 1.21-2.87]). The risk was still increased in euthyroid women with endometriosis relative to dysthyroid women with no endometriosis (RR 1.97 [95% CI 1.11-3.50]). There were no significant differences between the four groups for CPR, LBR, PLR and retrieved oocytes, immature oocytes, degenerated and unfertilized oocytes, cultured blastocysts, embryos and transferred embryos.<br /><br />Limitations: Limitations of the study were retrospective design, limited sample size, and use of different ovarian stimulation protocol.<br /><br />Conclusions: Thyroid autoimmunity seems more common in women with endometriosis and TSH over 2.5 mIU/L. However, there was no significant impact on in vitro fertilization and reproductive outcomes related to the coexistence of endometriosis, Hashimoto disease, and higher TSH levels. Due to limitations of the study, additional evidence is required to validate the abovementioned findings.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122353682"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122353682"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122353682; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122353682]").text(description); $(".js-view-count[data-work-id=122353682]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122353682; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122353682']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122353682, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122353682]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122353682,"title":"Coexistence of Endometriosis and Thyroid Autoimmunity in Infertile Women: Impact on in vitro Fertilization and Reproductive Outcomes","translated_title":"","metadata":{"doi":"10.1159/000539265","abstract":"Objectives: The objective of the study was to evaluate the prevalence and impact of impaired thyroid-stimulating hormone (TSH) levels on the reproductive outcomes of in vitro fertilization patients diagnosed with endometriosis and compared to controls without endometriosis.\n\nDesign: This is a retrospective cohort study on prospectively collected data.\n\nSetting: The study was conducted at tertiary care university hospital.\n\nParticipants: Participants were infertile women with histopathological diagnosis of endometriosis.\n\nMethods: For 12 months (January 2018 to January 2019), women were deemed suitable and subsequently divided according to serum TSH levels above or below 2.5 mIU/L and compared to patients without endometriosis. Needed sample size was at least 41 patients for each cohort of women. Co-primary outcomes were the live birth rate (LBR), clinical pregnancy rate (CPR), and pregnancy loss rate (PLR).\n\nResults: Overall, 226 women (45 with endometriosis and 181 controls without endometriosis) were included. Diagnoses of Hashimoto thyroiditis were significantly more frequent in women with rather than without endometriosis (14/45 [31.1%] vs. 27/181 [14.9%]; p = 0.012). Similarly, in women with endometriosis, Hashimoto diagnosis rates were higher with TSH ≥2.5 mIU/L compared to TSH \u0026lt;2.5 mIU/L (9/15 [60%] vs.5/30 [16.6%]; p = 0.001) so were the Hashimoto diagnosis rates in control group (women without endometriosis) with TSH ≥2.5 mIU/L compared to TSH \u0026lt;2.5 mIU/L (17/48 [35.4%] vs. 10/133 [7.5%], respectively; p = 0.001). Effect size analysis confirmed an increased risk of Hashimoto thyroiditis in women with endometriosis and TSH ≥2.5 mIU/L compared to women with endometriosis and TSH \u0026lt;2.5 mIU/L (risk ratio [RR] 3.60 [95% CI 1.46-8.86]) and in women with endometriosis and TSH ≥2.5 mIU/L compared to non-endometriotic euthyroid patients (RR 7.98 [95% CI 3.86-16.48]). Dysmenorrhea risk was higher in endometriotic euthyroid women compared to euthyroid patients with no endometriosis (RR 1.87 [95% CI 1.21-2.87]). The risk was still increased in euthyroid women with endometriosis relative to dysthyroid women with no endometriosis (RR 1.97 [95% CI 1.11-3.50]). There were no significant differences between the four groups for CPR, LBR, PLR and retrieved oocytes, immature oocytes, degenerated and unfertilized oocytes, cultured blastocysts, embryos and transferred embryos.\n\nLimitations: Limitations of the study were retrospective design, limited sample size, and use of different ovarian stimulation protocol.\n\nConclusions: Thyroid autoimmunity seems more common in women with endometriosis and TSH over 2.5 mIU/L. However, there was no significant impact on in vitro fertilization and reproductive outcomes related to the coexistence of endometriosis, Hashimoto disease, and higher TSH levels. Due to limitations of the study, additional evidence is required to validate the abovementioned findings.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Gynecologic and Obstetric Investigation"},"translated_abstract":"Objectives: The objective of the study was to evaluate the prevalence and impact of impaired thyroid-stimulating hormone (TSH) levels on the reproductive outcomes of in vitro fertilization patients diagnosed with endometriosis and compared to controls without endometriosis.\n\nDesign: This is a retrospective cohort study on prospectively collected data.\n\nSetting: The study was conducted at tertiary care university hospital.\n\nParticipants: Participants were infertile women with histopathological diagnosis of endometriosis.\n\nMethods: For 12 months (January 2018 to January 2019), women were deemed suitable and subsequently divided according to serum TSH levels above or below 2.5 mIU/L and compared to patients without endometriosis. Needed sample size was at least 41 patients for each cohort of women. Co-primary outcomes were the live birth rate (LBR), clinical pregnancy rate (CPR), and pregnancy loss rate (PLR).\n\nResults: Overall, 226 women (45 with endometriosis and 181 controls without endometriosis) were included. Diagnoses of Hashimoto thyroiditis were significantly more frequent in women with rather than without endometriosis (14/45 [31.1%] vs. 27/181 [14.9%]; p = 0.012). Similarly, in women with endometriosis, Hashimoto diagnosis rates were higher with TSH ≥2.5 mIU/L compared to TSH \u0026lt;2.5 mIU/L (9/15 [60%] vs.5/30 [16.6%]; p = 0.001) so were the Hashimoto diagnosis rates in control group (women without endometriosis) with TSH ≥2.5 mIU/L compared to TSH \u0026lt;2.5 mIU/L (17/48 [35.4%] vs. 10/133 [7.5%], respectively; p = 0.001). Effect size analysis confirmed an increased risk of Hashimoto thyroiditis in women with endometriosis and TSH ≥2.5 mIU/L compared to women with endometriosis and TSH \u0026lt;2.5 mIU/L (risk ratio [RR] 3.60 [95% CI 1.46-8.86]) and in women with endometriosis and TSH ≥2.5 mIU/L compared to non-endometriotic euthyroid patients (RR 7.98 [95% CI 3.86-16.48]). Dysmenorrhea risk was higher in endometriotic euthyroid women compared to euthyroid patients with no endometriosis (RR 1.87 [95% CI 1.21-2.87]). The risk was still increased in euthyroid women with endometriosis relative to dysthyroid women with no endometriosis (RR 1.97 [95% CI 1.11-3.50]). There were no significant differences between the four groups for CPR, LBR, PLR and retrieved oocytes, immature oocytes, degenerated and unfertilized oocytes, cultured blastocysts, embryos and transferred embryos.\n\nLimitations: Limitations of the study were retrospective design, limited sample size, and use of different ovarian stimulation protocol.\n\nConclusions: Thyroid autoimmunity seems more common in women with endometriosis and TSH over 2.5 mIU/L. However, there was no significant impact on in vitro fertilization and reproductive outcomes related to the coexistence of endometriosis, Hashimoto disease, and higher TSH levels. Due to limitations of the study, additional evidence is required to validate the abovementioned findings.","internal_url":"https://www.academia.edu/122353682/Coexistence_of_Endometriosis_and_Thyroid_Autoimmunity_in_Infertile_Women_Impact_on_in_vitro_Fertilization_and_Reproductive_Outcomes","translated_internal_url":"","created_at":"2024-07-25T22:04:12.371-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Coexistence_of_Endometriosis_and_Thyroid_Autoimmunity_in_Infertile_Women_Impact_on_in_vitro_Fertilization_and_Reproductive_Outcomes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"RGU3clJ0SXBBRVdiOWMrckdRSFdoaUMwaXhobWhwL3N3d0YyY0dYZng0TT0tLUo3cmRpb3VzYWdtbk1kNStqN3V4NXc9PQ==--e61d07bbf160cfaa107a65208edb9a5e0c1c5818"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":25630,"name":"Endocrinology \u0026 Metabolism","url":"https://www.academia.edu/Documents/in/Endocrinology_and_Metabolism"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"}],"urls":[{"id":43688843,"url":"https://karger.com/goi/article/doi/10.1159/000539265/907088/Coexistence-of-Endometriosis-and-Thyroid"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122244986"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122244986/Reproductive_Outcomes_in_Young_Women_with_Early_Stage_Cervical_Cancer_Greater_Than_2_cm_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review"><img alt="Research paper thumbnail of Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater Than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review" class="work-thumbnail" src="https://attachments.academia-assets.com/116952161/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122244986/Reproductive_Outcomes_in_Young_Women_with_Early_Stage_Cervical_Cancer_Greater_Than_2_cm_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review">Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater Than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review</a></div><div class="wp-workCard_item"><span>Medicina</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background and Objectives: Despite advancements in detection and treatment, cervical cancer remai...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background and Objectives: Despite advancements in detection and treatment, cervical cancer remains a significant health concern, particularly among young women of reproductive age. Limited data exists in the literature regarding fertility-sparing treatment (FST) of cervical cancers with tumor sizes greater than 2 cm. The objective of this systematic review was to evaluate the reproductive outcomes of women diagnosed with cervical cancer greater than 2 cm who underwent FST. Materials and Methods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies (retrospective or prospective) that reported reproductive outcomes of patients with cervical cancer >2 cm were considered eligible for inclusion in this systematic review (CRD42024521964). Studies describing only the oncologic outcomes, involving FST for cervical cancers less than 2 cm in size, and case reports were excluded. Results: Seventeen papers that met the abovementioned inclusion criteria were included in the present systematic review. In total, 443 patients with a cervical cancer larger than 2 cm were included in this systematic review. Eighty pregnancies occurred, with 24 miscarriages and 54 live births. Conclusions: FST appears to be a viable option for women of childbearing age diagnosed with cervical cancer larger than 2 cm. However, careful consideration is advised in interpreting these encouraging results, as they are subject to limitations, such as variability in study designs and potential biases. In addition, reproductive outcomes should be further cross-referenced with oncologic outcomes to clarify the potential risk-benefit ratio. It is critical to conduct further research using standardized approaches and larger participant groups to strengthen the validity of the conclusions drawn.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="19043a2be8763b37073d7ef31ffe1cec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116952161,"asset_id":122244986,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116952161/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122244986"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122244986"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122244986; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122244986]").text(description); $(".js-view-count[data-work-id=122244986]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122244986; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122244986']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122244986, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "19043a2be8763b37073d7ef31ffe1cec" } } $('.js-work-strip[data-work-id=122244986]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122244986,"title":"Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater Than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review","translated_title":"","metadata":{"doi":"10.3390/medicina60040608","abstract":"Background and Objectives: Despite advancements in detection and treatment, cervical cancer remains a significant health concern, particularly among young women of reproductive age. Limited data exists in the literature regarding fertility-sparing treatment (FST) of cervical cancers with tumor sizes greater than 2 cm. The objective of this systematic review was to evaluate the reproductive outcomes of women diagnosed with cervical cancer greater than 2 cm who underwent FST. Materials and Methods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies (retrospective or prospective) that reported reproductive outcomes of patients with cervical cancer \u003e2 cm were considered eligible for inclusion in this systematic review (CRD42024521964). Studies describing only the oncologic outcomes, involving FST for cervical cancers less than 2 cm in size, and case reports were excluded. 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Conclusions: FST appears to be a viable option for women of childbearing age diagnosed with cervical cancer larger than 2 cm. However, careful consideration is advised in interpreting these encouraging results, as they are subject to limitations, such as variability in study designs and potential biases. In addition, reproductive outcomes should be further cross-referenced with oncologic outcomes to clarify the potential risk-benefit ratio. 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122056566"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122056566/Isthmocele_and_Infertility"><img alt="Research paper thumbnail of Isthmocele and Infertility" class="work-thumbnail" src="https://attachments.academia-assets.com/116795252/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122056566/Isthmocele_and_Infertility">Isthmocele and Infertility</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AngelucciCecilia">Cecilia Angelucci</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AndreaTinelli2">Andrea Tinelli</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GiorgioBaldini4">Giorgio Baldini</a></span></div><div class="wp-workCard_item"><span>Journal of Clinical Medicine</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or insufficient healing of the uterine wall following a cesarean incision. It appears that isthmocele may impact a woman's quality of life as well as her reproductive capacity. The incidence of isthmocele can range from 20% to 70% in women who have undergone a cesarean section. This review aims to sum up the current knowledge about the effect of isthmocele on fertility and the possible therapeutic strategies to achieve pregnancy. However, currently, there is not sufficiently robust evidence to indicate the need for surgical correction in all asymptomatic patients seeking fertility. In cases where surgical correction of isthmocele is deemed necessary, it is advisable to evaluate residual myometrial thickness (RMT). For patients with RMT >2.5-3 mm, hysteroscopy appears to be the technique of choice. In cases where the residual tissue is lower, recourse to laparotomic, laparoscopic, or vaginal approaches is warranted.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2b1b288d3796102cb7624ddbcd7363bc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116795252,"asset_id":122056566,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116795252/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122056566"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122056566"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122056566; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122056566]").text(description); $(".js-view-count[data-work-id=122056566]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122056566; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122056566']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122056566, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2b1b288d3796102cb7624ddbcd7363bc" } } $('.js-work-strip[data-work-id=122056566]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122056566,"title":"Isthmocele and Infertility","translated_title":"","metadata":{"doi":"10.3390/jcm13082192","abstract":"Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or insufficient healing of the uterine wall following a cesarean incision. It appears that isthmocele may impact a woman's quality of life as well as her reproductive capacity. The incidence of isthmocele can range from 20% to 70% in women who have undergone a cesarean section. This review aims to sum up the current knowledge about the effect of isthmocele on fertility and the possible therapeutic strategies to achieve pregnancy. However, currently, there is not sufficiently robust evidence to indicate the need for surgical correction in all asymptomatic patients seeking fertility. In cases where surgical correction of isthmocele is deemed necessary, it is advisable to evaluate residual myometrial thickness (RMT). For patients with RMT \u003e2.5-3 mm, hysteroscopy appears to be the technique of choice. In cases where the residual tissue is lower, recourse to laparotomic, laparoscopic, or vaginal approaches is warranted.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Journal of Clinical Medicine"},"translated_abstract":"Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or insufficient healing of the uterine wall following a cesarean incision. It appears that isthmocele may impact a woman's quality of life as well as her reproductive capacity. The incidence of isthmocele can range from 20% to 70% in women who have undergone a cesarean section. This review aims to sum up the current knowledge about the effect of isthmocele on fertility and the possible therapeutic strategies to achieve pregnancy. However, currently, there is not sufficiently robust evidence to indicate the need for surgical correction in all asymptomatic patients seeking fertility. In cases where surgical correction of isthmocele is deemed necessary, it is advisable to evaluate residual myometrial thickness (RMT). For patients with RMT \u003e2.5-3 mm, hysteroscopy appears to be the technique of choice. In cases where the residual tissue is lower, recourse to laparotomic, laparoscopic, or vaginal approaches is warranted.","internal_url":"https://www.academia.edu/122056566/Isthmocele_and_Infertility","translated_internal_url":"","created_at":"2024-07-15T00:00:22.967-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42057658,"work_id":122056566,"tagging_user_id":12242463,"tagged_user_id":null,"co_author_invite_id":8197186,"email":"d***i@libero.itd","display_order":1,"name":"Giorgio Baldi","title":"Isthmocele and Infertility"},{"id":42057659,"work_id":122056566,"tagging_user_id":12242463,"tagged_user_id":323778881,"co_author_invite_id":173889,"email":"a***i@gmail.com","display_order":2,"name":"Antonio Malvasi","title":"Isthmocele and 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href="https://www.academia.edu/122035235/Impact_of_Thrombophilic_Polymorphisms_in_Antenatal_Women_on_Perinatal_Health_A_Single_Center_Prospective_Study"><img alt="Research paper thumbnail of Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study" class="work-thumbnail" src="https://attachments.academia-assets.com/116778595/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122035235/Impact_of_Thrombophilic_Polymorphisms_in_Antenatal_Women_on_Perinatal_Health_A_Single_Center_Prospective_Study">Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study</a></div><div class="wp-workCard_item"><span>Journal of Personalized Medicine</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Despite pregnancy's hypercoagulable state, the correlation between inherited thrombop...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Despite pregnancy's hypercoagulable state, the correlation between inherited thrombophilia and thrombotic adverse pregnancy outcomes remains uncertain. The objective of this study was to determine the prevalence of inherited thrombophilic polymorphisms among asymptomatic pregnant individuals and to examine their potential correlation with adverse perinatal outcomes. Methods: in this single-center prospective study, 105 healthy pregnant women were included. Genotyping was conducted for factor V Leiden (FVL), prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, and plasminogen activator inhibitor-1 (PAI-1), alongside the assessment of protein C (PC), protein S (PS), and antithrombin (AT) levels. The study analyzed the association between inherited thrombophilic polymorphisms and pregnancy complications linked to placental insufficiency, such as gestational hypertension (GH), preeclampsia (PE), intrauterine death (IUD), fetal growth restriction (FGR), and placental abruption. Results: The prevalence of identifiable thrombophilic polymorphism mutations was 61.9% (95% confidence interval-CI 52.4-70.8%), with the most common single mutation being PAI-1 4G/5G (12/105, 11.4%, 95% CI 6.4-18.5). The most frequent combined mutation was heterozygosity for MTHFR C677T and PAI-1 (12/105, 11.4%, 95% CI 6.4-18.5). Notably, no FVL homozygous carriers or single homozygous and heterozygous carriers for prothrombin polymorphisms were found. Additionally, no deficiencies in PC and AT were detected among participants. Except for homozygosity for PAI-1, none of the studied polymorphisms demonstrated a significant association with pregnancy complications linked to placental insufficiency. Conclusions: The asymptomatic carriers of inherited thrombophilic polymorphisms do not have an increased risk of adverse perinatal outcomes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aa51c4cfe3462d6f69193cc2717ae51f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116778595,"asset_id":122035235,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116778595/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122035235"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122035235"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122035235; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122035235]").text(description); $(".js-view-count[data-work-id=122035235]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122035235; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122035235']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122035235, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aa51c4cfe3462d6f69193cc2717ae51f" } } $('.js-work-strip[data-work-id=122035235]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122035235,"title":"Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study","translated_title":"","metadata":{"doi":"10.3390/jpm14040433","abstract":"Background: Despite pregnancy's hypercoagulable state, the correlation between inherited thrombophilia and thrombotic adverse pregnancy outcomes remains uncertain. The objective of this study was to determine the prevalence of inherited thrombophilic polymorphisms among asymptomatic pregnant individuals and to examine their potential correlation with adverse perinatal outcomes. Methods: in this single-center prospective study, 105 healthy pregnant women were included. Genotyping was conducted for factor V Leiden (FVL), prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, and plasminogen activator inhibitor-1 (PAI-1), alongside the assessment of protein C (PC), protein S (PS), and antithrombin (AT) levels. The study analyzed the association between inherited thrombophilic polymorphisms and pregnancy complications linked to placental insufficiency, such as gestational hypertension (GH), preeclampsia (PE), intrauterine death (IUD), fetal growth restriction (FGR), and placental abruption. Results: The prevalence of identifiable thrombophilic polymorphism mutations was 61.9% (95% confidence interval-CI 52.4-70.8%), with the most common single mutation being PAI-1 4G/5G (12/105, 11.4%, 95% CI 6.4-18.5). The most frequent combined mutation was heterozygosity for MTHFR C677T and PAI-1 (12/105, 11.4%, 95% CI 6.4-18.5). Notably, no FVL homozygous carriers or single homozygous and heterozygous carriers for prothrombin polymorphisms were found. Additionally, no deficiencies in PC and AT were detected among participants. Except for homozygosity for PAI-1, none of the studied polymorphisms demonstrated a significant association with pregnancy complications linked to placental insufficiency. Conclusions: The asymptomatic carriers of inherited thrombophilic polymorphisms do not have an increased risk of adverse perinatal outcomes.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Journal of Personalized Medicine"},"translated_abstract":"Background: Despite pregnancy's hypercoagulable state, the correlation between inherited thrombophilia and thrombotic adverse pregnancy outcomes remains uncertain. The objective of this study was to determine the prevalence of inherited thrombophilic polymorphisms among asymptomatic pregnant individuals and to examine their potential correlation with adverse perinatal outcomes. Methods: in this single-center prospective study, 105 healthy pregnant women were included. Genotyping was conducted for factor V Leiden (FVL), prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, and plasminogen activator inhibitor-1 (PAI-1), alongside the assessment of protein C (PC), protein S (PS), and antithrombin (AT) levels. The study analyzed the association between inherited thrombophilic polymorphisms and pregnancy complications linked to placental insufficiency, such as gestational hypertension (GH), preeclampsia (PE), intrauterine death (IUD), fetal growth restriction (FGR), and placental abruption. Results: The prevalence of identifiable thrombophilic polymorphism mutations was 61.9% (95% confidence interval-CI 52.4-70.8%), with the most common single mutation being PAI-1 4G/5G (12/105, 11.4%, 95% CI 6.4-18.5). The most frequent combined mutation was heterozygosity for MTHFR C677T and PAI-1 (12/105, 11.4%, 95% CI 6.4-18.5). Notably, no FVL homozygous carriers or single homozygous and heterozygous carriers for prothrombin polymorphisms were found. Additionally, no deficiencies in PC and AT were detected among participants. Except for homozygosity for PAI-1, none of the studied polymorphisms demonstrated a significant association with pregnancy complications linked to placental insufficiency. 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endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study" class="work-thumbnail" src="https://attachments.academia-assets.com/116755062/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122005009/Can_the_endometrioma_be_an_obstacle_to_complete_oocyte_retrieval_in_IVF_cycles_A_retrospective_study">Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/BaldiniDomenico">Domenico Baldini</a></span></div><div class="wp-workCard_item"><span>European Review for Medical and Pharmacological Sciences</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The study aimed to evaluate the utility and safety of ancillary maneuvers during oocyte retrieval...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The study aimed to evaluate the utility and safety of ancillary maneuvers during oocyte retrieval for patients with endometrioma that makes ovum pickup hard due to poor ovarian surgical accessibility. PATIENTS AND METHODS: Cases of 251 women with ovarian endometriomas undergoing in vitro fertilization (IVF) in our infertility unit were retrospectively analyzed to evaluate the clinical IVF cycle outcomes after oocyte retrieval. Controls (n = 251) were age-matched women without endometriomas who underwent an uncomplicated oocyte retrieval. RESULTS: No statistically significant differences were observed between groups except for the number of oocytes retrieved, which was higher in the control group than in the group of women with endometrioma. On the contrary, there were no differences between the experimental groups in the fertilization rate and number of embryos and neither were there in the pregnancy and live birth rate. Moreover, the surgical complications were infrequent and similar between the two analyzed groups. Accidental or voluntary endometrioma punctures were not accompanied by increases in the risk of a pelvic infection. CONCLUSIONS: In conclusion, patients with endometrioma can undergo high-performance oocyte recovery procedures thanks to safe accessory maneuvers during the ovum pickup .</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="87a827f8807a1f4e5d54cdd8dc26df61" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116755062,"asset_id":122005009,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116755062/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122005009"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122005009"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122005009; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122005009]").text(description); $(".js-view-count[data-work-id=122005009]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122005009; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122005009']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122005009, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "87a827f8807a1f4e5d54cdd8dc26df61" } } $('.js-work-strip[data-work-id=122005009]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122005009,"title":"Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study","translated_title":"","metadata":{"doi":"10.26355/eurrev_202404_35911","abstract":"The study aimed to evaluate the utility and safety of ancillary maneuvers during oocyte retrieval for patients with endometrioma that makes ovum pickup hard due to poor ovarian surgical accessibility. PATIENTS AND METHODS: Cases of 251 women with ovarian endometriomas undergoing in vitro fertilization (IVF) in our infertility unit were retrospectively analyzed to evaluate the clinical IVF cycle outcomes after oocyte retrieval. Controls (n = 251) were age-matched women without endometriomas who underwent an uncomplicated oocyte retrieval. RESULTS: No statistically significant differences were observed between groups except for the number of oocytes retrieved, which was higher in the control group than in the group of women with endometrioma. On the contrary, there were no differences between the experimental groups in the fertilization rate and number of embryos and neither were there in the pregnancy and live birth rate. Moreover, the surgical complications were infrequent and similar between the two analyzed groups. Accidental or voluntary endometrioma punctures were not accompanied by increases in the risk of a pelvic infection. CONCLUSIONS: In conclusion, patients with endometrioma can undergo high-performance oocyte recovery procedures thanks to safe accessory maneuvers during the ovum pickup .","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"European Review for Medical and Pharmacological Sciences"},"translated_abstract":"The study aimed to evaluate the utility and safety of ancillary maneuvers during oocyte retrieval for patients with endometrioma that makes ovum pickup hard due to poor ovarian surgical accessibility. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121668801"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121668801/Early_pregnancy_bleeding_after_assisted_reproductive_technology_a_common_adverse_event_that_does_not_always_affect_reproductive_outcome"><img alt="Research paper thumbnail of Early pregnancy bleeding after assisted reproductive technology: a common adverse event that does not always affect reproductive outcome" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121668801/Early_pregnancy_bleeding_after_assisted_reproductive_technology_a_common_adverse_event_that_does_not_always_affect_reproductive_outcome">Early pregnancy bleeding after assisted reproductive technology: a common adverse event that does not always affect reproductive outcome</a></div><div class="wp-workCard_item"><span>Evidence-Based Nursing</span><span>, 2024</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121668801"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121668801"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121668801; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121551856"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121551856/Analogies_between_HPV_Behavior_in_Oral_and_Vaginal_Cavity_Narrative_Review_on_the_Current_Evidence_in_the_Literature"><img alt="Research paper thumbnail of Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature" class="work-thumbnail" src="https://attachments.academia-assets.com/116397834/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121551856/Analogies_between_HPV_Behavior_in_Oral_and_Vaginal_Cavity_Narrative_Review_on_the_Current_Evidence_in_the_Literature">Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature</a></div><div class="wp-workCard_item"><span>Journal of Clinical Medicine</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Human genital papilloma virus infection is the most prevalent sexually transmitted infection in t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. It is estimated that more than 75% of sexually active women contract this infection in their lifetime. In 80% of young women, there is the clearance of the virus within 18-24 months. In developed countries, oral squamous cell carcinoma (OSCC) is now the most frequent human papilloma virus (HPV)-related cancer, having surpassed cervical cancer, and it is predicted that by 2030 most squamous cell carcinomas will be the HPV-related rather than non-HPV-related form. However, there are currently no screening programs for oral cavity infection. While the natural history of HPV infection in the cervix is well known, in the oropharynx, it is not entirely clear. Furthermore, the prevalence of HPV in the oropharynx is unknown. Published studies have found wide-ranging prevalence estimates of 2.6% to 50%. There are also conflicting results regarding the percentage of women presenting the same type of HPV at two mucosal sites, ranging from 0 to 60%. Additionally, the question arises as to whether oral infection can develop from genital HPV infection, through oral and genital contact or by self-inoculation, or whether it should be considered an independent event. However, there is still no consensus on these topics, nor on the relationship between genital and oral HPV infections. Therefore, this literature review aims to evaluate whether there is evidence of a connection between oral and cervical HPV, while also endorsing the usefulness of the screening of oral infection in patients with high-risk cervical HPV as a means of facilitating the diagnosis and early management of HPV-related oral lesions. Finally, this review emphasizes the recommendation for the use of the HPV vaccines in primary prevention in the male and female population as the most effective means of successfully counteracting the increasing incidence of OSCC to date.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7aa68f4b8b2c9a2579b3044d1df308d1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116397834,"asset_id":121551856,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116397834/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121551856"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121551856"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121551856; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121551856]").text(description); $(".js-view-count[data-work-id=121551856]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121551856; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121551856']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121551856, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7aa68f4b8b2c9a2579b3044d1df308d1" } } $('.js-work-strip[data-work-id=121551856]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121551856,"title":"Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature","translated_title":"","metadata":{"doi":"10.3390/jcm13051429","abstract":"Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121433831"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121433831/The_great_debate_Surgical_outcomes_of_laparoscopic_versus_laparotomic_myomectomy_A_meta_analysis_to_critically_evaluate_current_evidence_and_look_over_the_horizon"><img alt="Research paper thumbnail of The great debate: Surgical outcomes of laparoscopic versus laparotomic myomectomy. A meta-analysis to critically evaluate current evidence and look over the horizon" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121433831/The_great_debate_Surgical_outcomes_of_laparoscopic_versus_laparotomic_myomectomy_A_meta_analysis_to_critically_evaluate_current_evidence_and_look_over_the_horizon">The great debate: Surgical outcomes of laparoscopic versus laparotomic myomectomy. A meta-analysis to critically evaluate current evidence and look over the horizon</a></div><div class="wp-workCard_item"><span>European Journal of Obstetrics & Gynecology and Reproductive Biology</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Myomectomy is one of the most common surgical procedure in the field of gynecology. However, the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Myomectomy is one of the most common surgical procedure in the field of gynecology. However, the role of laparoscopic myomectomy is still debated for many factors, including surgical considerations, safety and fertility concerns, long-term outcomes, and cost-related issues. The aim of this study is to evaluate the surgical peri- and post-operative outcomes of laparoscopic and abdominal myomectomy. A systematic search for studies was performed up to June 2023 through MEDLINE, Pubmed, Embase. Studies reporting the comparison of surgical and obstetrical outcomes in laparoscopic versus laparotomic myomectomy were included for the following outcomes: time of surgery, estimated blood loss, decrease of postoperative hemoglobin, hospital stay, intra-operative complication rates, postoperative complications rates, postoperative analgesic use, postoperative pain at 24 h and pregnancy rate. The meta-analysis was performed using the Cochrane Review software. Fifty-six relevant articles were retrieved through the process of evidence acquisition. Eleven articles met inclusion criteria, for a total of 2,133 patients undergoing laparoscopic or laparotomic myomectomy. The estimated blood loss [standard mean differences (SMD) 0.72, IC 95 % 0.22 to 1.22], the hospital stays [SMD 3.12, IC 95 % 0.57 to 4.28], were significantly lower in laparoscopic than in open group. No statistically significant difference in intra-operative and post-operative complication rates, in pregnancy rate and others obstetrical outcomes between two surgical approaches were found. The findings of present metanalysis suggest that laparoscopic myomectomy offers multiple benefits, including reduced blood loss, shorter hospital stays, and less postoperative analgesic need, without a significant increase in complication rates and similar results in obstetrical outcomes when compared to abdominal myomectomy. However, the presence of few randomized studies on selected population may limit the generalizability of the findings to the entire population. Therefore, more well-designed studies or large population programdata to draw definitive conclusions are therefore warranted.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121433831"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121433831"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121433831; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121433831]").text(description); $(".js-view-count[data-work-id=121433831]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121433831; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121433831']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121433831, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121433831]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121433831,"title":"The great debate: Surgical outcomes of laparoscopic versus laparotomic myomectomy. 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Studies reporting the comparison of surgical and obstetrical outcomes in laparoscopic versus laparotomic myomectomy were included for the following outcomes: time of surgery, estimated blood loss, decrease of postoperative hemoglobin, hospital stay, intra-operative complication rates, postoperative complications rates, postoperative analgesic use, postoperative pain at 24 h and pregnancy rate. The meta-analysis was performed using the Cochrane Review software. Fifty-six relevant articles were retrieved through the process of evidence acquisition. Eleven articles met inclusion criteria, for a total of 2,133 patients undergoing laparoscopic or laparotomic myomectomy. The estimated blood loss [standard mean differences (SMD) 0.72, IC 95 % 0.22 to 1.22], the hospital stays [SMD 3.12, IC 95 % 0.57 to 4.28], were significantly lower in laparoscopic than in open group. No statistically significant difference in intra-operative and post-operative complication rates, in pregnancy rate and others obstetrical outcomes between two surgical approaches were found. The findings of present metanalysis suggest that laparoscopic myomectomy offers multiple benefits, including reduced blood loss, shorter hospital stays, and less postoperative analgesic need, without a significant increase in complication rates and similar results in obstetrical outcomes when compared to abdominal myomectomy. However, the presence of few randomized studies on selected population may limit the generalizability of the findings to the entire population. Therefore, more well-designed studies or large population programdata to draw definitive conclusions are therefore warranted.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"European Journal of Obstetrics \u0026 Gynecology and Reproductive Biology"},"translated_abstract":"Myomectomy is one of the most common surgical procedure in the field of gynecology. However, the role of laparoscopic myomectomy is still debated for many factors, including surgical considerations, safety and fertility concerns, long-term outcomes, and cost-related issues. The aim of this study is to evaluate the surgical peri- and post-operative outcomes of laparoscopic and abdominal myomectomy. A systematic search for studies was performed up to June 2023 through MEDLINE, Pubmed, Embase. Studies reporting the comparison of surgical and obstetrical outcomes in laparoscopic versus laparotomic myomectomy were included for the following outcomes: time of surgery, estimated blood loss, decrease of postoperative hemoglobin, hospital stay, intra-operative complication rates, postoperative complications rates, postoperative analgesic use, postoperative pain at 24 h and pregnancy rate. The meta-analysis was performed using the Cochrane Review software. Fifty-six relevant articles were retrieved through the process of evidence acquisition. Eleven articles met inclusion criteria, for a total of 2,133 patients undergoing laparoscopic or laparotomic myomectomy. The estimated blood loss [standard mean differences (SMD) 0.72, IC 95 % 0.22 to 1.22], the hospital stays [SMD 3.12, IC 95 % 0.57 to 4.28], were significantly lower in laparoscopic than in open group. No statistically significant difference in intra-operative and post-operative complication rates, in pregnancy rate and others obstetrical outcomes between two surgical approaches were found. The findings of present metanalysis suggest that laparoscopic myomectomy offers multiple benefits, including reduced blood loss, shorter hospital stays, and less postoperative analgesic need, without a significant increase in complication rates and similar results in obstetrical outcomes when compared to abdominal myomectomy. However, the presence of few randomized studies on selected population may limit the generalizability of the findings to the entire population. Therefore, more well-designed studies or large population programdata to draw definitive conclusions are therefore warranted.","internal_url":"https://www.academia.edu/121433831/The_great_debate_Surgical_outcomes_of_laparoscopic_versus_laparotomic_myomectomy_A_meta_analysis_to_critically_evaluate_current_evidence_and_look_over_the_horizon","translated_internal_url":"","created_at":"2024-06-23T22:06:38.925-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_great_debate_Surgical_outcomes_of_laparoscopic_versus_laparotomic_myomectomy_A_meta_analysis_to_critically_evaluate_current_evidence_and_look_over_the_horizon","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"NXF2bjZMV3BnQkVURzdOa2s4MkJoSlcwMGdsZWxhcXdsQUs1UUFLZ3lWaz0tLURObE4ra2JmUWRybHBhTDV1SHc0ZUE9PQ==--acb24a89d0a6f863e493a7e0ccc488fb673027d1"},"attachments":[],"research_interests":[{"id":618,"name":"Gynaecology","url":"https://www.academia.edu/Documents/in/Gynaecology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"},{"id":1584584,"name":"Obgyn and Gynecology","url":"https://www.academia.edu/Documents/in/Obgyn_and_Gynecology"}],"urls":[{"id":43189148,"url":"https://pubmed.ncbi.nlm.nih.gov/38581885/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120760515"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120760515/Effect_of_maternal_age_and_BMI_on_induction_of_labor_using_oral_misoprostol_in_late_term_pregnancies_a_retrospective_cross_sectional_study"><img alt="Research paper thumbnail of Effect of maternal age and BMI on induction of labor using oral misoprostol in late-term pregnancies: a retrospective cross-sectional study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120760515/Effect_of_maternal_age_and_BMI_on_induction_of_labor_using_oral_misoprostol_in_late_term_pregnancies_a_retrospective_cross_sectional_study">Effect of maternal age and BMI on induction of labor using oral misoprostol in late-term pregnancies: a retrospective cross-sectional study</a></div><div class="wp-workCard_item"><span>Gynecologic and Obstetric Investigation</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: To evaluate the effect of maternal age and body mass index (BMI) on oral misoprostol ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: To evaluate the effect of maternal age and body mass index (BMI) on oral misoprostol induction of labor for late-term pregnancies.<br /><br />Design: Retrospective cross-sectional study (ClinicalTrial iD: NCT06184139), including only late-term pregnancies in healthy nulliparous women and single cephalic fetus with normal birthweight. Specify the type of study (randomized, prospective cohort, case-control, other) and include the number of study subjects (cases/controls), treatment type and duration, sampling procedures if applicable.<br /><br />Participants/materials, setting, methods: One-hundred-and-four pregnant women underwent induction of labor with oral misoprostol for late-term pregnancy on the 290th day of gestation. Study population was divided in two groups based on age (<35 and ≥35 years) and obesity (BMI <30 and ≥30). Statistical analysis was performed using SPSS V.21.0 (IBM Corporation, Armonk, NY). The inclusion of 51 women from each of the two arms achieved 80% power with an alpha error of 0.05. Continuous variables were expressed as the mean and standard deviation (SD). Categorical variables are expressed as frequencies and percentages. Results No statistically significant differences were recorded between younger and older women. Obese women reported a longer time between the last dose of misoprostol and cervical dilation of 6 cm (p=0.01), a longer time between the last dose of misoprostol and delivery (p=0.04), and a higher rate of grade II vaginal lacerations (p=0.02). Limitations While this study contributes novel insights into cervical ripening and labor induction using oral misoprostol for late-term pregnancies, its scope is limited by the retrospective study design, inherently carrying biases compared to prospective approaches, and the limited sample size within the study cohort. Conclusions Maternal BMI is a factor negatively influencing the efficacy of oral misoprostol for induction of labor in late-term pregnancy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120760515"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120760515"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120760515; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120760515]").text(description); $(".js-view-count[data-work-id=120760515]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120760515; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120760515']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 120760515, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120760515]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120760515,"title":"Effect of maternal age and BMI on induction of labor using oral misoprostol in late-term pregnancies: a retrospective cross-sectional study","translated_title":"","metadata":{"doi":"10.1159/000538374","abstract":"Objectives: To evaluate the effect of maternal age and body mass index (BMI) on oral misoprostol induction of labor for late-term pregnancies.\n\nDesign: Retrospective cross-sectional study (ClinicalTrial iD: NCT06184139), including only late-term pregnancies in healthy nulliparous women and single cephalic fetus with normal birthweight. Specify the type of study (randomized, prospective cohort, case-control, other) and include the number of study subjects (cases/controls), treatment type and duration, sampling procedures if applicable.\n\nParticipants/materials, setting, methods: One-hundred-and-four pregnant women underwent induction of labor with oral misoprostol for late-term pregnancy on the 290th day of gestation. Study population was divided in two groups based on age (\u003c35 and ≥35 years) and obesity (BMI \u003c30 and ≥30). Statistical analysis was performed using SPSS V.21.0 (IBM Corporation, Armonk, NY). The inclusion of 51 women from each of the two arms achieved 80% power with an alpha error of 0.05. Continuous variables were expressed as the mean and standard deviation (SD). Categorical variables are expressed as frequencies and percentages. Results No statistically significant differences were recorded between younger and older women. Obese women reported a longer time between the last dose of misoprostol and cervical dilation of 6 cm (p=0.01), a longer time between the last dose of misoprostol and delivery (p=0.04), and a higher rate of grade II vaginal lacerations (p=0.02). Limitations While this study contributes novel insights into cervical ripening and labor induction using oral misoprostol for late-term pregnancies, its scope is limited by the retrospective study design, inherently carrying biases compared to prospective approaches, and the limited sample size within the study cohort. Conclusions Maternal BMI is a factor negatively influencing the efficacy of oral misoprostol for induction of labor in late-term pregnancy.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Gynecologic and Obstetric Investigation"},"translated_abstract":"Objectives: To evaluate the effect of maternal age and body mass index (BMI) on oral misoprostol induction of labor for late-term pregnancies.\n\nDesign: Retrospective cross-sectional study (ClinicalTrial iD: NCT06184139), including only late-term pregnancies in healthy nulliparous women and single cephalic fetus with normal birthweight. Specify the type of study (randomized, prospective cohort, case-control, other) and include the number of study subjects (cases/controls), treatment type and duration, sampling procedures if applicable.\n\nParticipants/materials, setting, methods: One-hundred-and-four pregnant women underwent induction of labor with oral misoprostol for late-term pregnancy on the 290th day of gestation. Study population was divided in two groups based on age (\u003c35 and ≥35 years) and obesity (BMI \u003c30 and ≥30). Statistical analysis was performed using SPSS V.21.0 (IBM Corporation, Armonk, NY). The inclusion of 51 women from each of the two arms achieved 80% power with an alpha error of 0.05. Continuous variables were expressed as the mean and standard deviation (SD). Categorical variables are expressed as frequencies and percentages. Results No statistically significant differences were recorded between younger and older women. Obese women reported a longer time between the last dose of misoprostol and cervical dilation of 6 cm (p=0.01), a longer time between the last dose of misoprostol and delivery (p=0.04), and a higher rate of grade II vaginal lacerations (p=0.02). Limitations While this study contributes novel insights into cervical ripening and labor induction using oral misoprostol for late-term pregnancies, its scope is limited by the retrospective study design, inherently carrying biases compared to prospective approaches, and the limited sample size within the study cohort. Conclusions Maternal BMI is a factor negatively influencing the efficacy of oral misoprostol for induction of labor in late-term pregnancy.","internal_url":"https://www.academia.edu/120760515/Effect_of_maternal_age_and_BMI_on_induction_of_labor_using_oral_misoprostol_in_late_term_pregnancies_a_retrospective_cross_sectional_study","translated_internal_url":"","created_at":"2024-06-09T02:32:36.586-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_maternal_age_and_BMI_on_induction_of_labor_using_oral_misoprostol_in_late_term_pregnancies_a_retrospective_cross_sectional_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"Yjl2eENPWEk4VEFNMHFUL0xIWDBtVjc1WkVqR0pLSk5aY1hXZDJIR2pmbz0tLXdmSGFRVTAyWWhxdjh1MnkzRjJ5d3c9PQ==--b153db4046d26adec0a855eb1c196c56b1f814ae"},"attachments":[],"research_interests":[{"id":3770,"name":"Metabolism","url":"https://www.academia.edu/Documents/in/Metabolism"},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity"},{"id":25630,"name":"Endocrinology \u0026 Metabolism","url":"https://www.academia.edu/Documents/in/Endocrinology_and_Metabolism"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"},{"id":1584584,"name":"Obgyn and Gynecology","url":"https://www.academia.edu/Documents/in/Obgyn_and_Gynecology"}],"urls":[{"id":42782625,"url":"https://pubmed.ncbi.nlm.nih.gov/38565086/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="118241104"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/118241104/Management_of_Uterine_Fibroids_and_Sarcomas_The_Palermo_Position_Paper"><img alt="Research paper thumbnail of Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper" class="work-thumbnail" src="https://attachments.academia-assets.com/113914032/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/118241104/Management_of_Uterine_Fibroids_and_Sarcomas_The_Palermo_Position_Paper">Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper</a></div><div class="wp-workCard_item"><span>Gynecologic and Obstetric Investigation</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cell...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cells of the myometrium, constituting the most prevalent pathology within the female genital tract. Uterine sarcomas, although rare, still represent a diagnostic challenge and should be managed in centers with adequate expertise in gynecological oncology.<br /><br />Objectives: This article is aimed to summarize and discuss cutting-edge elements about the diagnosis and management of uterine fibroids and sarcomas.<br /><br />Methods: This paper is a report of the lectures presented in an expert meeting about uterine fibroids and sarcomas held in Palermo in February 2023.<br /><br />Outcome: Overall, the combination of novel molecular pathways may help combine biomarkers and expert ultrasound for the differential diagnosis of uterine fibroids and sarcomas. On the one hand, molecular and cellular maps of uterine fibroids and matched myometrium may enhance our understanding of tumor development compared to histologic analysis and whole tissue transcriptomics, and support the development of minimally invasive treatment strategies; on the other hand, ultrasound imaging allows in most of the cases a proper mapping the fibroids and to differentiate between benign and malignant lesions, which need appropriate management.<br /><br />Conclusions and outlook: The choice of uterine fibroid management, including pharmacological approaches, surgical treatment, or other strategies, such as high-intensity focused ultrasound (HIFU), should be carefully considered, taking into account the characteristics of the patient and reproductive prognosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7044dd1ea07b1557785543406c7cacb9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113914032,"asset_id":118241104,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113914032/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="118241104"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="118241104"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 118241104; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=118241104]").text(description); $(".js-view-count[data-work-id=118241104]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 118241104; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='118241104']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 118241104, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7044dd1ea07b1557785543406c7cacb9" } } $('.js-work-strip[data-work-id=118241104]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":118241104,"title":"Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper","translated_title":"","metadata":{"doi":"10.1159/000537730","abstract":"Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cells of the myometrium, constituting the most prevalent pathology within the female genital tract. Uterine sarcomas, although rare, still represent a diagnostic challenge and should be managed in centers with adequate expertise in gynecological oncology.\n\nObjectives: This article is aimed to summarize and discuss cutting-edge elements about the diagnosis and management of uterine fibroids and sarcomas.\n\nMethods: This paper is a report of the lectures presented in an expert meeting about uterine fibroids and sarcomas held in Palermo in February 2023.\n\nOutcome: Overall, the combination of novel molecular pathways may help combine biomarkers and expert ultrasound for the differential diagnosis of uterine fibroids and sarcomas. On the one hand, molecular and cellular maps of uterine fibroids and matched myometrium may enhance our understanding of tumor development compared to histologic analysis and whole tissue transcriptomics, and support the development of minimally invasive treatment strategies; on the other hand, ultrasound imaging allows in most of the cases a proper mapping the fibroids and to differentiate between benign and malignant lesions, which need appropriate management.\n\nConclusions and outlook: The choice of uterine fibroid management, including pharmacological approaches, surgical treatment, or other strategies, such as high-intensity focused ultrasound (HIFU), should be carefully considered, taking into account the characteristics of the patient and reproductive prognosis.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Gynecologic and Obstetric Investigation"},"translated_abstract":"Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cells of the myometrium, constituting the most prevalent pathology within the female genital tract. Uterine sarcomas, although rare, still represent a diagnostic challenge and should be managed in centers with adequate expertise in gynecological oncology.\n\nObjectives: This article is aimed to summarize and discuss cutting-edge elements about the diagnosis and management of uterine fibroids and sarcomas.\n\nMethods: This paper is a report of the lectures presented in an expert meeting about uterine fibroids and sarcomas held in Palermo in February 2023.\n\nOutcome: Overall, the combination of novel molecular pathways may help combine biomarkers and expert ultrasound for the differential diagnosis of uterine fibroids and sarcomas. On the one hand, molecular and cellular maps of uterine fibroids and matched myometrium may enhance our understanding of tumor development compared to histologic analysis and whole tissue transcriptomics, and support the development of minimally invasive treatment strategies; on the other hand, ultrasound imaging allows in most of the cases a proper mapping the fibroids and to differentiate between benign and malignant lesions, which need appropriate management.\n\nConclusions and outlook: The choice of uterine fibroid management, including pharmacological approaches, surgical treatment, or other strategies, such as high-intensity focused ultrasound (HIFU), should be carefully considered, taking into account the characteristics of the patient and reproductive prognosis.","internal_url":"https://www.academia.edu/118241104/Management_of_Uterine_Fibroids_and_Sarcomas_The_Palermo_Position_Paper","translated_internal_url":"","created_at":"2024-04-28T22:10:50.226-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41580308,"work_id":118241104,"tagging_user_id":12242463,"tagged_user_id":null,"co_author_invite_id":7622721,"email":"a***a@unipa.it","display_order":1,"name":"Antonio Laganà","title":"Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper"},{"id":41580309,"work_id":118241104,"tagging_user_id":12242463,"tagged_user_id":38626512,"co_author_invite_id":null,"email":"m***e@uni-muenster.de","affiliation":"University of Münster","display_order":2,"name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117131259"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117131259/Prophylactic_Antibiotics_before_Gynecologic_Surgery_A_Comprehensive_Review_of_Guidelines"><img alt="Research paper thumbnail of Prophylactic Antibiotics before Gynecologic Surgery: A Comprehensive Review of Guidelines" class="work-thumbnail" src="https://attachments.academia-assets.com/113068650/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117131259/Prophylactic_Antibiotics_before_Gynecologic_Surgery_A_Comprehensive_Review_of_Guidelines">Prophylactic Antibiotics before Gynecologic Surgery: A Comprehensive Review of Guidelines</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/StamatiosPetousis">Stamatios Petousis</a></span></div><div class="wp-workCard_item"><span>Journal of Personalized Medicine</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Surgical site infections (SSIs) refer to infections in the incision, organ, or postoperative spac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Surgical site infections (SSIs) refer to infections in the incision, organ, or postoperative space. As common healthcare-associated infections, SSIs correlate with prolonged hospital stay, additional procedures, ICU stay, and higher mortality rates. Around 8-10% of gynecologic surgery patients may experience infectious complications, influenced by microbial contamination, surgical nature, and patient factors. The goal of this narrative review is to compare and merge recommendations from globally published guidelines concerning the utilization of antibiotics in the perioperative phase. A comparative descriptive/narrative review of the guidelines issued by the American College of Obstetrics and Gynecology (ACOG), Society of Obstetricians and Gynecologists of Canada (SOGC), Royal College of Obstetricians and Gynecologists (RCOG), National Institute for Health and Care Excellence (NICE), Royal Australian and New Zealand College of Obstetricians and Gynecologists (RANZCOG), European Society of Gynecologic Oncology (ESGO), Société Française d' Anésthesie et de Réanimation (SFAR), Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), and Hellenic Society of Obstetrics and Gynecology (HSOG) was conducted. For hysterectomy, first/second-generation cephalosporins are suggested, with metronidazole as an option. Laparoscopy without entering the bowel or vagina typically does not require prophylaxis. Uterine evacuation and hysteroscopy may involve doxycycline or azithromycin based on risk factors, whereas, for vulvectomy, cefazolin is recommended. Urogynecology procedures may include cefazolin with metronidazole. In cases of penicillin allergy, cephalosporins are suggested, and, for obese patients, adjusted doses are advised. Additional doses may be needed for prolonged procedures or excessive blood loss. Timing recommendations are 15-60 min before incision, adjusting for specific antibiotics. Clear indications exist for certain surgeries like hysterectomy, termination of pregnancy, and urogynecologic procedures. Conversely, procedures such as intrauterine device insertion, hysteroscopy, and laparoscopy typically do not necessitate antibiotic prophylaxis. For several other procedures, the evidence is inconclusive, while considering dose, timing, and indications can mitigate infectious complications and provide benefits for the healthcare system.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e50eeef0e8086c8ad5002206b3deb47e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113068650,"asset_id":117131259,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113068650/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117131259"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117131259"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117131259; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117131259]").text(description); $(".js-view-count[data-work-id=117131259]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117131259; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117131259']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117131259, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e50eeef0e8086c8ad5002206b3deb47e" } } $('.js-work-strip[data-work-id=117131259]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117131259,"title":"Prophylactic Antibiotics before Gynecologic Surgery: A Comprehensive Review of Guidelines","translated_title":"","metadata":{"doi":"10.3390/jpm14030327","abstract":"Surgical site infections (SSIs) refer to infections in the incision, organ, or postoperative space. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117089781"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117089781/Reproductive_and_Oncologic_Outcomes_in_Young_Women_with_Stage_IA_and_Grade_2_Endometrial_Carcinoma_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review"><img alt="Research paper thumbnail of Reproductive and Oncologic Outcomes in Young Women with Stage IA and Grade 2 Endometrial Carcinoma Undergoing Fertility-Sparing Treatment: A Systematic Review" class="work-thumbnail" src="https://attachments.academia-assets.com/113041225/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117089781/Reproductive_and_Oncologic_Outcomes_in_Young_Women_with_Stage_IA_and_Grade_2_Endometrial_Carcinoma_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review">Reproductive and Oncologic Outcomes in Young Women with Stage IA and Grade 2 Endometrial Carcinoma Undergoing Fertility-Sparing Treatment: A Systematic Review</a></div><div class="wp-workCard_item"><span>Biomolecules</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Endometrial cancer (EC) is the most common gynecological malignancy in both Europe an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Endometrial cancer (EC) is the most common gynecological malignancy in both Europe and the USA. Approximately 3-5% of cases occur in women of reproductive age. Fertility-sparing treatment (FST) options are available, but very limited evidence regarding grade 2 (G2) ECs exists in the current literature. This systematic review aimed to comprehensively evaluate reproductive and oncologic outcomes among young women diagnosed with stage IA or G2EC disease who underwent FST.<br /><br />Methods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies that reported the oncologic and reproductive outcomes of patients with stage IA and G2EC tumors who underwent FST were considered eligible for inclusion in this systematic review (CRD42023484892). Studies describing only the FST for endometrial hyperplasia or G1 EC were excluded.<br /><br />Results: Twenty-two papers that met the abovementioned inclusion criteria were included in the present systematic review. Preliminary analysis suggested encouraging oncologic and reproductive outcomes after FST.<br /><br />Conclusions: The FST approach may represent a feasible and safe option for women of childbearing age diagnosed with G2EC. Despite these promising findings, cautious interpretation is warranted due to inherent limitations, including heterogeneity in study designs and potential biases. Further research with standardized methodologies and larger sample sizes is imperative for obtaining more robust conclusions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a0a2028f3bd00ab4e0d7acf2e11c9bb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113041225,"asset_id":117089781,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113041225/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117089781"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117089781"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117089781; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117089781]").text(description); $(".js-view-count[data-work-id=117089781]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117089781; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117089781']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117089781, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a0a2028f3bd00ab4e0d7acf2e11c9bb" } } $('.js-work-strip[data-work-id=117089781]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117089781,"title":"Reproductive and Oncologic Outcomes in Young Women with Stage IA and Grade 2 Endometrial Carcinoma Undergoing Fertility-Sparing Treatment: A Systematic Review","translated_title":"","metadata":{"doi":"10.3390/biom14030306","abstract":"Background: Endometrial cancer (EC) is the most common gynecological malignancy in both Europe and the USA. Approximately 3-5% of cases occur in women of reproductive age. Fertility-sparing treatment (FST) options are available, but very limited evidence regarding grade 2 (G2) ECs exists in the current literature. This systematic review aimed to comprehensively evaluate reproductive and oncologic outcomes among young women diagnosed with stage IA or G2EC disease who underwent FST.\n\nMethods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies that reported the oncologic and reproductive outcomes of patients with stage IA and G2EC tumors who underwent FST were considered eligible for inclusion in this systematic review (CRD42023484892). 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wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123445950/Vulvar_lipoma_rare_case_rare_location">Vulvar lipoma: rare case, rare location</a></div><div class="wp-workCard_item"><span>Italian Journal of Gynæcology & Obstetrics</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the literature.<br />Case presentation. We reported clinical, diagnostic and therapeutical choices of a 44-year aged patient with a rare abnormally sized vulvar lipoma. A Diamond-shaped skin incision was performed and the neoformation was removed without capsule lesions. A vaginal plastic skin-reducing was performed to reduce redundant tissue. The deep planes of the lesion have been reconstructed to avoid leakage.<br />Conclusions. This kind of lipomas can be potentially diagnosed through clinical examination because of their specific characteristics. However, imaging is advisable to differentiate benign neoplasm from malignant one. Different approaches can be achieved for lipomas based on the size of lump, patient’s feelings and necessities and the operation goals; however, the complete surgical excision with the removal of capsules to prevent recurrence remains the treatment of choice for vulvar lipomas. Different surgical approaches aim to achieve better esthetical results, less scarring, and less colour discordance of the connected tissues post-surgery. Surgery is the gold standard for treatment of vulvar lesions. Currently, there is no evidence of long-term follow-up in the literature. We recommend an adequate counselling with the patient to understand their needs and encouraging them to seek medical advice and to tailor the treatment of such lesions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="377330743865e2ea764d63b709a68821" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117874429,"asset_id":123445950,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117874429/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123445950"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123445950"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123445950; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=123445950]").text(description); $(".js-view-count[data-work-id=123445950]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 123445950; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='123445950']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 123445950, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "377330743865e2ea764d63b709a68821" } } $('.js-work-strip[data-work-id=123445950]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":123445950,"title":"Vulvar lipoma: rare case, rare location","translated_title":"","metadata":{"doi":"10.36129/jog.2023.134","abstract":"Background. Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the literature.\nCase presentation. We reported clinical, diagnostic and therapeutical choices of a 44-year aged patient with a rare abnormally sized vulvar lipoma. A Diamond-shaped skin incision was performed and the neoformation was removed without capsule lesions. A vaginal plastic skin-reducing was performed to reduce redundant tissue. The deep planes of the lesion have been reconstructed to avoid leakage.\nConclusions. This kind of lipomas can be potentially diagnosed through clinical examination because of their specific characteristics. However, imaging is advisable to differentiate benign neoplasm from malignant one. Different approaches can be achieved for lipomas based on the size of lump, patient’s feelings and necessities and the operation goals; however, the complete surgical excision with the removal of capsules to prevent recurrence remains the treatment of choice for vulvar lipomas. Different surgical approaches aim to achieve better esthetical results, less scarring, and less colour discordance of the connected tissues post-surgery. Surgery is the gold standard for treatment of vulvar lesions. Currently, there is no evidence of long-term follow-up in the literature. We recommend an adequate counselling with the patient to understand their needs and encouraging them to seek medical advice and to tailor the treatment of such lesions.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Italian Journal of Gynæcology \u0026 Obstetrics"},"translated_abstract":"Background. Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the literature.\nCase presentation. We reported clinical, diagnostic and therapeutical choices of a 44-year aged patient with a rare abnormally sized vulvar lipoma. A Diamond-shaped skin incision was performed and the neoformation was removed without capsule lesions. A vaginal plastic skin-reducing was performed to reduce redundant tissue. The deep planes of the lesion have been reconstructed to avoid leakage.\nConclusions. This kind of lipomas can be potentially diagnosed through clinical examination because of their specific characteristics. However, imaging is advisable to differentiate benign neoplasm from malignant one. Different approaches can be achieved for lipomas based on the size of lump, patient’s feelings and necessities and the operation goals; however, the complete surgical excision with the removal of capsules to prevent recurrence remains the treatment of choice for vulvar lipomas. Different surgical approaches aim to achieve better esthetical results, less scarring, and less colour discordance of the connected tissues post-surgery. Surgery is the gold standard for treatment of vulvar lesions. Currently, there is no evidence of long-term follow-up in the literature. We recommend an adequate counselling with the patient to understand their needs and encouraging them to seek medical advice and to tailor the treatment of such lesions.","internal_url":"https://www.academia.edu/123445950/Vulvar_lipoma_rare_case_rare_location","translated_internal_url":"","created_at":"2024-09-01T09:45:03.752-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":117874429,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117874429/thumbnails/1.jpg","file_name":"570_Vulvar_Lipoma._Rare_case_rare_location.pdf","download_url":"https://www.academia.edu/attachments/117874429/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_lipoma_rare_case_rare_location.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117874429/570_Vulvar_Lipoma._Rare_case_rare_location-libre.pdf?1725211054=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_lipoma_rare_case_rare_location.pdf\u0026Expires=1732736057\u0026Signature=V4eOi8bzLKxXlYoPKvN3TLhGe5mbR5jlB4nfhr0kWxxIiA3200dnTdYx2BQ27FeS136~jEiUyAyS5W3pob~um51I0bLlt8JRaCwUBbgkbGjVeyvmAZioApHsFo6ayjmH4QLWqcYiqHjbUHUVGi0~3POFVL7gZKwakFAFCMiyX0jcibv~B94bd1W~DBQrA~DSOWpFa3yratHA-ZDc3OF2vVgaRrM~YCycQW2vdze4S1XmoA2BL8nKOz479plczfsq1-51AwDl9iSF2UKGUPsS74NPq9h6~9Bl5jbGmtsBh2bkvh-dzX0ec9gEUu~tMbq2KdFzkks2ucif6Hvlg8GXCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Vulvar_lipoma_rare_case_rare_location","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"TmV6dUUrSWpNUEIwU0JIS2NycXBMVzVxZmpxd01mN0hQVmJKZzRSc3h2Zz0tLU5WcDlGdCtrdlRRa1loUzZnL2g3eWc9PQ==--8e39d3f60d2104fe22883a3cdf46500cd9114424"},"attachments":[{"id":117874429,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117874429/thumbnails/1.jpg","file_name":"570_Vulvar_Lipoma._Rare_case_rare_location.pdf","download_url":"https://www.academia.edu/attachments/117874429/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_lipoma_rare_case_rare_location.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117874429/570_Vulvar_Lipoma._Rare_case_rare_location-libre.pdf?1725211054=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_lipoma_rare_case_rare_location.pdf\u0026Expires=1732736057\u0026Signature=V4eOi8bzLKxXlYoPKvN3TLhGe5mbR5jlB4nfhr0kWxxIiA3200dnTdYx2BQ27FeS136~jEiUyAyS5W3pob~um51I0bLlt8JRaCwUBbgkbGjVeyvmAZioApHsFo6ayjmH4QLWqcYiqHjbUHUVGi0~3POFVL7gZKwakFAFCMiyX0jcibv~B94bd1W~DBQrA~DSOWpFa3yratHA-ZDc3OF2vVgaRrM~YCycQW2vdze4S1XmoA2BL8nKOz479plczfsq1-51AwDl9iSF2UKGUPsS74NPq9h6~9Bl5jbGmtsBh2bkvh-dzX0ec9gEUu~tMbq2KdFzkks2ucif6Hvlg8GXCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":618,"name":"Gynaecology","url":"https://www.academia.edu/Documents/in/Gynaecology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"},{"id":1584584,"name":"Obgyn and Gynecology","url":"https://www.academia.edu/Documents/in/Obgyn_and_Gynecology"},{"id":1789935,"name":"Ob/gyn","url":"https://www.academia.edu/Documents/in/Ob_gyn-1"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122867561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122867561/Silent_spontaneous_uterine_rupture_in_a_term_pregnancy_with_extrusion_of_an_intact_amniotic_sac_and_without_maternal_and_neonatal_morbidity_and_mortality"><img alt="Research paper thumbnail of Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and mortality" class="work-thumbnail" src="https://attachments.academia-assets.com/117439334/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122867561/Silent_spontaneous_uterine_rupture_in_a_term_pregnancy_with_extrusion_of_an_intact_amniotic_sac_and_without_maternal_and_neonatal_morbidity_and_mortality">Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and mortality</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/SorrentinoFelice">Felice Sorrentino</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FeliceSorrentino2">Felice Sorrentino</a></span></div><div class="wp-workCard_item"><span>Italian Journal of Gynæcology & Obstetrics</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Uterine rupture in pregnancy is a rare and catastrophic complication with a high inci...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Uterine rupture in pregnancy is a rare and catastrophic complication with a high incidence of fetal and maternal morbidity and mortality. Silent spontaneous uterine rupture without maternal or neonatal morbidity or mortality is very rare.<br />Case presentation. We describe a case of silent spontaneous uterine rupture diagnosed during a planned cesarean section in a patient at 38+4 weeks’ gestation with two previous cesarean sections. The mother and newborn were discharged three days later in good health and without complications.<br />Conclusions. Worldwide, the frequency of cesarean deliveries has increased in recent decades and uterine rupture is a very rare catastrophic emergency that can have dramatic consequences. Our case report shows that uterine rupture can occur in pregnancy before labour without any signs or symptoms. Despite the uterine rupture with extrusion of the intact amniotic sac, there were no complications for the mother or the foetus. Timely diagnosis is crucial and future research should find more reproducible parameters to objectify the risk of silent uterine rupture and define the timing of delivery of previous cesarean sections requiring a new surgical delivery. All patients with previous cesarean sections should be counselled about the possibility of early delivery by cesarean section.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7fcec18aa9933dec5b30fdcdc240b4dd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117439334,"asset_id":122867561,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117439334/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122867561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122867561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122867561; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122867561]").text(description); $(".js-view-count[data-work-id=122867561]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122867561; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122867561']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122867561, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7fcec18aa9933dec5b30fdcdc240b4dd" } } $('.js-work-strip[data-work-id=122867561]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122867561,"title":"Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and mortality","translated_title":"","metadata":{"doi":"10.36129/jog.2024.153","abstract":"Background. Uterine rupture in pregnancy is a rare and catastrophic complication with a high incidence of fetal and maternal morbidity and mortality. Silent spontaneous uterine rupture without maternal or neonatal morbidity or mortality is very rare.\nCase presentation. We describe a case of silent spontaneous uterine rupture diagnosed during a planned cesarean section in a patient at 38+4 weeks’ gestation with two previous cesarean sections. The mother and newborn were discharged three days later in good health and without complications.\nConclusions. Worldwide, the frequency of cesarean deliveries has increased in recent decades and uterine rupture is a very rare catastrophic emergency that can have dramatic consequences. Our case report shows that uterine rupture can occur in pregnancy before labour without any signs or symptoms. Despite the uterine rupture with extrusion of the intact amniotic sac, there were no complications for the mother or the foetus. Timely diagnosis is crucial and future research should find more reproducible parameters to objectify the risk of silent uterine rupture and define the timing of delivery of previous cesarean sections requiring a new surgical delivery. All patients with previous cesarean sections should be counselled about the possibility of early delivery by cesarean section.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Italian Journal of Gynæcology \u0026 Obstetrics"},"translated_abstract":"Background. Uterine rupture in pregnancy is a rare and catastrophic complication with a high incidence of fetal and maternal morbidity and mortality. Silent spontaneous uterine rupture without maternal or neonatal morbidity or mortality is very rare.\nCase presentation. We describe a case of silent spontaneous uterine rupture diagnosed during a planned cesarean section in a patient at 38+4 weeks’ gestation with two previous cesarean sections. The mother and newborn were discharged three days later in good health and without complications.\nConclusions. Worldwide, the frequency of cesarean deliveries has increased in recent decades and uterine rupture is a very rare catastrophic emergency that can have dramatic consequences. Our case report shows that uterine rupture can occur in pregnancy before labour without any signs or symptoms. Despite the uterine rupture with extrusion of the intact amniotic sac, there were no complications for the mother or the foetus. Timely diagnosis is crucial and future research should find more reproducible parameters to objectify the risk of silent uterine rupture and define the timing of delivery of previous cesarean sections requiring a new surgical delivery. All patients with previous cesarean sections should be counselled about the possibility of early delivery by cesarean section.","internal_url":"https://www.academia.edu/122867561/Silent_spontaneous_uterine_rupture_in_a_term_pregnancy_with_extrusion_of_an_intact_amniotic_sac_and_without_maternal_and_neonatal_morbidity_and_mortality","translated_internal_url":"","created_at":"2024-08-14T03:19:51.338-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42223258,"work_id":122867561,"tagging_user_id":12242463,"tagged_user_id":300691524,"co_author_invite_id":null,"email":"f***3@gmail.com","display_order":1,"name":"Felice Sorrentino","title":"Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122844338/When_one_size_does_not_fit_all_Reconsidering_PCOS_etiology_diagnosis_clinical_subgroups_and_subgroup_specific_treatments"><img alt="Research paper thumbnail of When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments" class="work-thumbnail" src="https://attachments.academia-assets.com/117422033/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122844338/When_one_size_does_not_fit_all_Reconsidering_PCOS_etiology_diagnosis_clinical_subgroups_and_subgroup_specific_treatments">When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments</a></div><div class="wp-workCard_item"><span>Endocrine and Metabolic Science</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion of women. Due to its heterogeneity, the best diagnostic strategy has been a matter of contention. Since 1990 scientific societies in the field of human reproduction have tried to define the pivotal criteria for the diagnosis of PCOS. The consensus Rotterdam diagnostic criteria included the presence of hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology (PCOM), and have now been updated to evidence based diagnostic criteria in the 2018 and 2023 International Guideline diagnostic criteria endorsed by 39 societies internationally. Within the Rotterdam Criteria, at least two out of three of the above-mentioned features are required to be present to diagnose PCOS, resulting in four phenotypes being identified: phenotype A, characterized by the presence of all the features, phenotype B, exhibiting hyperandrogenism and oligo-anovulation, phenotype C, presenting as hyperandrogenism and PCOM and finally the phenotype D that is characterized by oligo-anovulation and PCOM, lacking the hyperandrogenic component. However, it is the hypothesis of the EGOI group that the Rotterdam phenotypes A, B, and C have a different underlying causality to phenotype D. Recent studies have highlighted the strong correlation between insulin resistance and hyperandrogenism, and the pivotal role of these factors in driving ovarian alterations, such as oligo-anovulation and follicular functional cyst formation. This new understanding of PCOS pathogenesis has led the authors to hypothesis that phenotypes A, B, and C are endocrine-metabolic syndromes with a metabolic clinical onset. Conversely, the absence of hyperandrogenism and metabolic disturbances in phenotype D suggests a different origin of this condition, and point towards novel pathophysiological mechanisms; however, these are still not fully understood. Further questions have been raised regarding the suitability of the “phenotypes” described by the Rotterdam Criteria by the publication by recent GWAS studies, which demonstrated that these phenotypes should be considered clinical subtypes as they are not reflected in the genetic picture. Hence, by capturing the heterogeneity of this complex disorder, current diagnostic criteria may benefit from a reassessment and the evaluation of additional parameters such as insulin resistance and endometrial thickness, with the purpose of not only improving their diagnostic accuracy but also of assigning an appropriate and personalized treatment. In this framework, the present overview aims to analyze the diagnostic criteria currently recognized by the scientific community and assess the suitability of their application in clinical practice in light of the newly emerging evidence.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="13b44d6210a559a0791ed516a0616ead" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117422033,"asset_id":122844338,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117422033/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122844338"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122844338"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122844338; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122844338]").text(description); $(".js-view-count[data-work-id=122844338]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122844338; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122844338']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122844338, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "13b44d6210a559a0791ed516a0616ead" } } $('.js-work-strip[data-work-id=122844338]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122844338,"title":"When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments","translated_title":"","metadata":{"doi":"10.1016/j.endmts.2024.100159","abstract":"Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion of women. 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122808467"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122808467/The_importance_of_a_multidisciplinary_approach_in_the_treatment_of_uterine_fibroids"><img alt="Research paper thumbnail of The importance of a multidisciplinary approach in the treatment of uterine fibroids" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122808467/The_importance_of_a_multidisciplinary_approach_in_the_treatment_of_uterine_fibroids">The importance of a multidisciplinary approach in the treatment of uterine fibroids</a></div><div class="wp-workCard_item"><span>Gazzetta Medica Italiana Archivio per le Scienze Mediche</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122808467"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122808467"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122808467; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122711902/Hormonal_Therapies_before_in_vitro_fertilization_in_women_with_endometriosis_The_Minotaurs_Labyrinth_and_the_Ariadnes_Thread"><img alt="Research paper thumbnail of Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122711902/Hormonal_Therapies_before_in_vitro_fertilization_in_women_with_endometriosis_The_Minotaurs_Labyrinth_and_the_Ariadnes_Thread">Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread</a></div><div class="wp-workCard_item"><span>Best Practice & Research Clinical Obstetrics & Gynaecology</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In recent years, prolonged pre-cycle hormonal regimens gained attention as a mean of improving the assisted reproduction technologies (ART) success rates in endometriosis patients. GnRH agonists, dienogest, medroxyprogesterone acetate, and aromatase inhibitors are the most studied medications. Conflicting results and a high risk of bias exist in almost all of the conducted studies in the field. However, current evidence suggests that pre-cycle treatment with GnRH agonists may be beneficial for patients with stage III/IV endometriosis. Dienogest and medroxyprogesterone acetate-based progestin-primed ovarian stimulation protocol was shown to be comparable to the prolonged GnRH agonists protocol. Finally, aromatase inhibitors seem to be of limited benefit to the assisted reproductive outcomes of endometriosis patients. Although it is challenging to draw any clinical conclusions, pre-cycle hormonal treatments seem to be best indicated in endometriosis patients who had previously failed ART treatment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122711902"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122711902"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122711902; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122711902]").text(description); $(".js-view-count[data-work-id=122711902]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122711902; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122711902']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122711902, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122711902]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122711902,"title":"Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread","translated_title":"","metadata":{"doi":"10.1016/j.bpobgyn.2024.102500","abstract":"Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In recent years, prolonged pre-cycle hormonal regimens gained attention as a mean of improving the assisted reproduction technologies (ART) success rates in endometriosis patients. GnRH agonists, dienogest, medroxyprogesterone acetate, and aromatase inhibitors are the most studied medications. Conflicting results and a high risk of bias exist in almost all of the conducted studies in the field. However, current evidence suggests that pre-cycle treatment with GnRH agonists may be beneficial for patients with stage III/IV endometriosis. Dienogest and medroxyprogesterone acetate-based progestin-primed ovarian stimulation protocol was shown to be comparable to the prolonged GnRH agonists protocol. Finally, aromatase inhibitors seem to be of limited benefit to the assisted reproductive outcomes of endometriosis patients. Although it is challenging to draw any clinical conclusions, pre-cycle hormonal treatments seem to be best indicated in endometriosis patients who had previously failed ART treatment.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Best Practice \u0026 Research Clinical Obstetrics \u0026 Gynaecology"},"translated_abstract":"Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In recent years, prolonged pre-cycle hormonal regimens gained attention as a mean of improving the assisted reproduction technologies (ART) success rates in endometriosis patients. GnRH agonists, dienogest, medroxyprogesterone acetate, and aromatase inhibitors are the most studied medications. Conflicting results and a high risk of bias exist in almost all of the conducted studies in the field. However, current evidence suggests that pre-cycle treatment with GnRH agonists may be beneficial for patients with stage III/IV endometriosis. Dienogest and medroxyprogesterone acetate-based progestin-primed ovarian stimulation protocol was shown to be comparable to the prolonged GnRH agonists protocol. Finally, aromatase inhibitors seem to be of limited benefit to the assisted reproductive outcomes of endometriosis patients. Although it is challenging to draw any clinical conclusions, pre-cycle hormonal treatments seem to be best indicated in endometriosis patients who had previously failed ART treatment.","internal_url":"https://www.academia.edu/122711902/Hormonal_Therapies_before_in_vitro_fertilization_in_women_with_endometriosis_The_Minotaurs_Labyrinth_and_the_Ariadnes_Thread","translated_internal_url":"","created_at":"2024-08-09T01:52:55.842-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Hormonal_Therapies_before_in_vitro_fertilization_in_women_with_endometriosis_The_Minotaurs_Labyrinth_and_the_Ariadnes_Thread","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"OUMxbXZ5Tk02d0wvTGcwRUZCZHRpdmdKREllMURUb04vbGRUU2dISEhHcz0tLUo5VWloRkhld0FmNkVlc05yOWdhbGc9PQ==--0f2d4fcb484aa39ae9458fbc98bf3855d4b368f0"},"attachments":[],"research_interests":[{"id":618,"name":"Gynaecology","url":"https://www.academia.edu/Documents/in/Gynaecology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":81288,"name":"Assisted Reproductive Technologies","url":"https://www.academia.edu/Documents/in/Assisted_Reproductive_Technologies"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"},{"id":1584584,"name":"Obgyn and Gynecology","url":"https://www.academia.edu/Documents/in/Obgyn_and_Gynecology"}],"urls":[{"id":43899313,"url":"https://pubmed.ncbi.nlm.nih.gov/38772765/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122535283"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122535283/Effects_of_herbal_compounds_on_various_aspects_of_endometriosis_treatment_a_systematic_review"><img alt="Research paper thumbnail of Effects of herbal compounds on various aspects of endometriosis treatment: a systematic review" class="work-thumbnail" src="https://attachments.academia-assets.com/117178102/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122535283/Effects_of_herbal_compounds_on_various_aspects_of_endometriosis_treatment_a_systematic_review">Effects of herbal compounds on various aspects of endometriosis treatment: a systematic review</a></div><div class="wp-workCard_item"><span>European Review for Medical and Pharmacological Sciences</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Endometriosis means the presence of tissue similar to normal endometrium outside the uterus. Alth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Endometriosis means the presence of tissue similar to normal endometrium outside the uterus. Although surgical, hormonal, and analgesic treatment relieves symptoms and improves fertility, it is associated with side effects and a high recurrence rate. Alternative medicines like medicinal plants have been used for the treatment of chronic diseases. Given the global importance of endometriosis as a chronic disease affecting over 15% of all women in their fertile period, this systematic review aimed to give a comprehensive view of research on medicinal plants. MATERIALS AND METHODS: Comprehensive searches were performed on three databases, including PubMed/MEDLINE, Web of Science Core Collection (Indexes = SCI-EXPANDED, SS-CI, A, and HCI Timespan), and Scopus, to identify papers published until June 2023. Keywords, such as "Endometriosis" and "Herbal Medicine", were used to search. A manual search of valid journals followed by a manual search of the references of the retrieved full-text articles was performed. All retrieved articles were imported into a database into Endnote X9. Articles that did not meet the inclusion criteria were excluded from the study, and the full texts of all the articles that met the inclusion criteria were assessed. Studies that evaluated the effects of herbal compounds on various aspects of endometriosis treatment were included in the review. RESULTS: In total, 11 studies were included in the present study. The evidence showed that in addition to safety, drugs available alongside treatments could play an effective role in improving the symptoms associated with endometriosis. In this study, the positive results of using Chinese treatments were reported in aspects such as fertility rate, pain, endometriosis recurrence rate, quality of life, sexual function, CA-125 level, and menopause symptoms. CONCLUSIONS: A wide range of preclinical and clinical studies evaluated the effectiveness and safety of medicinal plants in the treatment of endometriosis symptoms. Thus, alternative treatments for endometriosis with no or low side effects should be included in the holistic treatment of endometriosis upfront. However, there is still a need for well-designed trials to investigate standard interventions and specific and safe doses of herbal medicines.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ce6b3bb1338f1be28ea3ec8e992f262c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117178102,"asset_id":122535283,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117178102/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122535283"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122535283"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122535283; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122535283]").text(description); $(".js-view-count[data-work-id=122535283]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122535283; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122535283']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122535283, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ce6b3bb1338f1be28ea3ec8e992f262c" } } $('.js-work-strip[data-work-id=122535283]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122535283,"title":"Effects of herbal compounds on various aspects of endometriosis treatment: a systematic review","translated_title":"","metadata":{"doi":"10.26355/eurrev_202405_36182","abstract":"Endometriosis means the presence of tissue similar to normal endometrium outside the uterus. Although surgical, hormonal, and analgesic treatment relieves symptoms and improves fertility, it is associated with side effects and a high recurrence rate. Alternative medicines like medicinal plants have been used for the treatment of chronic diseases. Given the global importance of endometriosis as a chronic disease affecting over 15% of all women in their fertile period, this systematic review aimed to give a comprehensive view of research on medicinal plants. MATERIALS AND METHODS: Comprehensive searches were performed on three databases, including PubMed/MEDLINE, Web of Science Core Collection (Indexes = SCI-EXPANDED, SS-CI, A, and HCI Timespan), and Scopus, to identify papers published until June 2023. Keywords, such as \"Endometriosis\" and \"Herbal Medicine\", were used to search. A manual search of valid journals followed by a manual search of the references of the retrieved full-text articles was performed. All retrieved articles were imported into a database into Endnote X9. Articles that did not meet the inclusion criteria were excluded from the study, and the full texts of all the articles that met the inclusion criteria were assessed. Studies that evaluated the effects of herbal compounds on various aspects of endometriosis treatment were included in the review. RESULTS: In total, 11 studies were included in the present study. The evidence showed that in addition to safety, drugs available alongside treatments could play an effective role in improving the symptoms associated with endometriosis. In this study, the positive results of using Chinese treatments were reported in aspects such as fertility rate, pain, endometriosis recurrence rate, quality of life, sexual function, CA-125 level, and menopause symptoms. CONCLUSIONS: A wide range of preclinical and clinical studies evaluated the effectiveness and safety of medicinal plants in the treatment of endometriosis symptoms. Thus, alternative treatments for endometriosis with no or low side effects should be included in the holistic treatment of endometriosis upfront. However, there is still a need for well-designed trials to investigate standard interventions and specific and safe doses of herbal medicines.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"European Review for Medical and Pharmacological Sciences"},"translated_abstract":"Endometriosis means the presence of tissue similar to normal endometrium outside the uterus. Although surgical, hormonal, and analgesic treatment relieves symptoms and improves fertility, it is associated with side effects and a high recurrence rate. Alternative medicines like medicinal plants have been used for the treatment of chronic diseases. Given the global importance of endometriosis as a chronic disease affecting over 15% of all women in their fertile period, this systematic review aimed to give a comprehensive view of research on medicinal plants. MATERIALS AND METHODS: Comprehensive searches were performed on three databases, including PubMed/MEDLINE, Web of Science Core Collection (Indexes = SCI-EXPANDED, SS-CI, A, and HCI Timespan), and Scopus, to identify papers published until June 2023. Keywords, such as \"Endometriosis\" and \"Herbal Medicine\", were used to search. A manual search of valid journals followed by a manual search of the references of the retrieved full-text articles was performed. All retrieved articles were imported into a database into Endnote X9. Articles that did not meet the inclusion criteria were excluded from the study, and the full texts of all the articles that met the inclusion criteria were assessed. Studies that evaluated the effects of herbal compounds on various aspects of endometriosis treatment were included in the review. RESULTS: In total, 11 studies were included in the present study. The evidence showed that in addition to safety, drugs available alongside treatments could play an effective role in improving the symptoms associated with endometriosis. In this study, the positive results of using Chinese treatments were reported in aspects such as fertility rate, pain, endometriosis recurrence rate, quality of life, sexual function, CA-125 level, and menopause symptoms. CONCLUSIONS: A wide range of preclinical and clinical studies evaluated the effectiveness and safety of medicinal plants in the treatment of endometriosis symptoms. Thus, alternative treatments for endometriosis with no or low side effects should be included in the holistic treatment of endometriosis upfront. However, there is still a need for well-designed trials to investigate standard interventions and specific and safe doses of herbal medicines.","internal_url":"https://www.academia.edu/122535283/Effects_of_herbal_compounds_on_various_aspects_of_endometriosis_treatment_a_systematic_review","translated_internal_url":"","created_at":"2024-08-02T09:43:25.675-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42157303,"work_id":122535283,"tagging_user_id":12242463,"tagged_user_id":null,"co_author_invite_id":5804907,"email":"a***a@hotmail.com","display_order":1,"name":"A. Laganà","title":"Effects of herbal compounds on various aspects of endometriosis treatment: a systematic review"},{"id":42157304,"work_id":122535283,"tagging_user_id":12242463,"tagged_user_id":139424579,"co_author_invite_id":null,"email":"i***t@uksh.de","display_order":2,"name":"I. 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and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413312"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413312/Long_term_therapy_with_dienogest_or_other_oral_cyclic_estrogen_progestogen_can_reduce_the_need_for_ovarian_endometrioma_surgery"><img alt="Research paper thumbnail of Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma surgery" class="work-thumbnail" src="https://attachments.academia-assets.com/117081017/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413312/Long_term_therapy_with_dienogest_or_other_oral_cyclic_estrogen_progestogen_can_reduce_the_need_for_ovarian_endometrioma_surgery">Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma surgery</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MatteoEpis">Matteo Epis</a></span></div><div class="wp-workCard_item"><span>Womens Health (Lond)</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Almost 10% of women in reproductive age are diagnosed with ovarian endometriomas and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Almost 10% of women in reproductive age are diagnosed with ovarian endometriomas and can experience symptoms and infertility disorders. Ovarian endometriomas can be treated with medical or surgical therapy. Objective: To assess whether long-term therapy with dienogest or oral cyclic estrogen-progestogens is effective in reducing the size of ovarian endometriomas, alleviating associated symptoms, and reducing the requirement for surgery. Design: Prospective non-interventional cohort study. Methods: We enrolled childbearing women diagnosed with ovarian endometriomas. We collected demographic, clinical, and surgical data, including the evaluation of ovarian endometrioma-associated symptoms and pain using the visual analog scale. We grouped the women according to treatment regimen into dienogest, estrogen-progestogens, and no-treatment. Patient's assessment was performed at baseline and after 12 months evaluating the largest ovarian endometrioma diameter (in millimeters) and the associated symptoms. Furthermore, we analyzed the impact of hormonal treatment in a subgroup of women fulfilling at baseline the criteria for a first-line surgical approach (ovarian endometrioma > 30 mm with visual analog scale > 8 or ovarian endometrioma > 40 mm before assisted reproductive treatments or any ovarian endometrioma(s) > 60 mm). Results: We enrolled 142 patients: 62, 38, and 42 in dienogest, estrogen-progestogens, and no-treatment groups, respectively. No significant differences were found regarding baseline characteristics. After 12 months, the mean largest ovarian endometrioma diameter increased in the no-treatment group (31.1 versus 33.8; p < 0.01), while a significant reduction was registered in the dienogest (35.1 versus 25.8; p < 0.01) and estrogen-progestogens (28.4 versus 16.7; p < 0.01) groups; no significant difference in ovarian endometrioma diameter reduction between these two latter groups was noted (p = 0.18). Ovarian endometrioma-associated symptoms and pain improved in dienogest and estrogenprogestogens groups, with a significantly greater effect for dienogest than for estrogen-progestogens for dysmenorrhea (74% versus 59%; p < 0.01). In the subgroup of women eligible for first-line surgery at baseline, long-term treatment with dienogest and estrogen-progestogens reduced surgical eligibility by 30%.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="75047536bba04a20f48f404ed16124c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117081017,"asset_id":122413312,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117081017/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413312"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413312"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413312; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413312]").text(description); $(".js-view-count[data-work-id=122413312]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413312; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413312']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122413312, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "75047536bba04a20f48f404ed16124c3" } } $('.js-work-strip[data-work-id=122413312]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413312,"title":"Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma surgery","translated_title":"","metadata":{"doi":"10.1177/17455057241252573","abstract":"Background: Almost 10% of women in reproductive age are diagnosed with ovarian endometriomas and can experience symptoms and infertility disorders. Ovarian endometriomas can be treated with medical or surgical therapy. Objective: To assess whether long-term therapy with dienogest or oral cyclic estrogen-progestogens is effective in reducing the size of ovarian endometriomas, alleviating associated symptoms, and reducing the requirement for surgery. Design: Prospective non-interventional cohort study. Methods: We enrolled childbearing women diagnosed with ovarian endometriomas. We collected demographic, clinical, and surgical data, including the evaluation of ovarian endometrioma-associated symptoms and pain using the visual analog scale. We grouped the women according to treatment regimen into dienogest, estrogen-progestogens, and no-treatment. Patient's assessment was performed at baseline and after 12 months evaluating the largest ovarian endometrioma diameter (in millimeters) and the associated symptoms. Furthermore, we analyzed the impact of hormonal treatment in a subgroup of women fulfilling at baseline the criteria for a first-line surgical approach (ovarian endometrioma \u003e 30 mm with visual analog scale \u003e 8 or ovarian endometrioma \u003e 40 mm before assisted reproductive treatments or any ovarian endometrioma(s) \u003e 60 mm). Results: We enrolled 142 patients: 62, 38, and 42 in dienogest, estrogen-progestogens, and no-treatment groups, respectively. No significant differences were found regarding baseline characteristics. After 12 months, the mean largest ovarian endometrioma diameter increased in the no-treatment group (31.1 versus 33.8; p \u003c 0.01), while a significant reduction was registered in the dienogest (35.1 versus 25.8; p \u003c 0.01) and estrogen-progestogens (28.4 versus 16.7; p \u003c 0.01) groups; no significant difference in ovarian endometrioma diameter reduction between these two latter groups was noted (p = 0.18). Ovarian endometrioma-associated symptoms and pain improved in dienogest and estrogenprogestogens groups, with a significantly greater effect for dienogest than for estrogen-progestogens for dysmenorrhea (74% versus 59%; p \u003c 0.01). In the subgroup of women eligible for first-line surgery at baseline, long-term treatment with dienogest and estrogen-progestogens reduced surgical eligibility by 30%.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Womens Health (Lond)"},"translated_abstract":"Background: Almost 10% of women in reproductive age are diagnosed with ovarian endometriomas and can experience symptoms and infertility disorders. Ovarian endometriomas can be treated with medical or surgical therapy. Objective: To assess whether long-term therapy with dienogest or oral cyclic estrogen-progestogens is effective in reducing the size of ovarian endometriomas, alleviating associated symptoms, and reducing the requirement for surgery. Design: Prospective non-interventional cohort study. Methods: We enrolled childbearing women diagnosed with ovarian endometriomas. We collected demographic, clinical, and surgical data, including the evaluation of ovarian endometrioma-associated symptoms and pain using the visual analog scale. We grouped the women according to treatment regimen into dienogest, estrogen-progestogens, and no-treatment. Patient's assessment was performed at baseline and after 12 months evaluating the largest ovarian endometrioma diameter (in millimeters) and the associated symptoms. Furthermore, we analyzed the impact of hormonal treatment in a subgroup of women fulfilling at baseline the criteria for a first-line surgical approach (ovarian endometrioma \u003e 30 mm with visual analog scale \u003e 8 or ovarian endometrioma \u003e 40 mm before assisted reproductive treatments or any ovarian endometrioma(s) \u003e 60 mm). Results: We enrolled 142 patients: 62, 38, and 42 in dienogest, estrogen-progestogens, and no-treatment groups, respectively. No significant differences were found regarding baseline characteristics. After 12 months, the mean largest ovarian endometrioma diameter increased in the no-treatment group (31.1 versus 33.8; p \u003c 0.01), while a significant reduction was registered in the dienogest (35.1 versus 25.8; p \u003c 0.01) and estrogen-progestogens (28.4 versus 16.7; p \u003c 0.01) groups; no significant difference in ovarian endometrioma diameter reduction between these two latter groups was noted (p = 0.18). Ovarian endometrioma-associated symptoms and pain improved in dienogest and estrogenprogestogens groups, with a significantly greater effect for dienogest than for estrogen-progestogens for dysmenorrhea (74% versus 59%; p \u003c 0.01). In the subgroup of women eligible for first-line surgery at baseline, long-term treatment with dienogest and estrogen-progestogens reduced surgical eligibility by 30%.","internal_url":"https://www.academia.edu/122413312/Long_term_therapy_with_dienogest_or_other_oral_cyclic_estrogen_progestogen_can_reduce_the_need_for_ovarian_endometrioma_surgery","translated_internal_url":"","created_at":"2024-07-28T09:33:08.208-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42125814,"work_id":122413312,"tagging_user_id":12242463,"tagged_user_id":272341019,"co_author_invite_id":null,"email":"f***i@unibs.it","display_order":1,"name":"Federi Ferrari","title":"Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma 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"profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122353682"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122353682/Coexistence_of_Endometriosis_and_Thyroid_Autoimmunity_in_Infertile_Women_Impact_on_in_vitro_Fertilization_and_Reproductive_Outcomes"><img alt="Research paper thumbnail of Coexistence of Endometriosis and Thyroid Autoimmunity in Infertile Women: Impact on in vitro Fertilization and Reproductive Outcomes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122353682/Coexistence_of_Endometriosis_and_Thyroid_Autoimmunity_in_Infertile_Women_Impact_on_in_vitro_Fertilization_and_Reproductive_Outcomes">Coexistence of Endometriosis and Thyroid Autoimmunity in Infertile Women: Impact on in vitro Fertilization and Reproductive Outcomes</a></div><div class="wp-workCard_item"><span>Gynecologic and Obstetric Investigation</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: The objective of the study was to evaluate the prevalence and impact of impaired thyr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: The objective of the study was to evaluate the prevalence and impact of impaired thyroid-stimulating hormone (TSH) levels on the reproductive outcomes of in vitro fertilization patients diagnosed with endometriosis and compared to controls without endometriosis.<br /><br />Design: This is a retrospective cohort study on prospectively collected data.<br /><br />Setting: The study was conducted at tertiary care university hospital.<br /><br />Participants: Participants were infertile women with histopathological diagnosis of endometriosis.<br /><br />Methods: For 12 months (January 2018 to January 2019), women were deemed suitable and subsequently divided according to serum TSH levels above or below 2.5 mIU/L and compared to patients without endometriosis. Needed sample size was at least 41 patients for each cohort of women. Co-primary outcomes were the live birth rate (LBR), clinical pregnancy rate (CPR), and pregnancy loss rate (PLR).<br /><br />Results: Overall, 226 women (45 with endometriosis and 181 controls without endometriosis) were included. Diagnoses of Hashimoto thyroiditis were significantly more frequent in women with rather than without endometriosis (14/45 [31.1%] vs. 27/181 [14.9%]; p = 0.012). Similarly, in women with endometriosis, Hashimoto diagnosis rates were higher with TSH ≥2.5 mIU/L compared to TSH &lt;2.5 mIU/L (9/15 [60%] vs.5/30 [16.6%]; p = 0.001) so were the Hashimoto diagnosis rates in control group (women without endometriosis) with TSH ≥2.5 mIU/L compared to TSH &lt;2.5 mIU/L (17/48 [35.4%] vs. 10/133 [7.5%], respectively; p = 0.001). Effect size analysis confirmed an increased risk of Hashimoto thyroiditis in women with endometriosis and TSH ≥2.5 mIU/L compared to women with endometriosis and TSH &lt;2.5 mIU/L (risk ratio [RR] 3.60 [95% CI 1.46-8.86]) and in women with endometriosis and TSH ≥2.5 mIU/L compared to non-endometriotic euthyroid patients (RR 7.98 [95% CI 3.86-16.48]). Dysmenorrhea risk was higher in endometriotic euthyroid women compared to euthyroid patients with no endometriosis (RR 1.87 [95% CI 1.21-2.87]). The risk was still increased in euthyroid women with endometriosis relative to dysthyroid women with no endometriosis (RR 1.97 [95% CI 1.11-3.50]). There were no significant differences between the four groups for CPR, LBR, PLR and retrieved oocytes, immature oocytes, degenerated and unfertilized oocytes, cultured blastocysts, embryos and transferred embryos.<br /><br />Limitations: Limitations of the study were retrospective design, limited sample size, and use of different ovarian stimulation protocol.<br /><br />Conclusions: Thyroid autoimmunity seems more common in women with endometriosis and TSH over 2.5 mIU/L. However, there was no significant impact on in vitro fertilization and reproductive outcomes related to the coexistence of endometriosis, Hashimoto disease, and higher TSH levels. Due to limitations of the study, additional evidence is required to validate the abovementioned findings.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122353682"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122353682"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122353682; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122353682]").text(description); $(".js-view-count[data-work-id=122353682]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122353682; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122353682']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122353682, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122353682]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122353682,"title":"Coexistence of Endometriosis and Thyroid Autoimmunity in Infertile Women: Impact on in vitro Fertilization and Reproductive Outcomes","translated_title":"","metadata":{"doi":"10.1159/000539265","abstract":"Objectives: The objective of the study was to evaluate the prevalence and impact of impaired thyroid-stimulating hormone (TSH) levels on the reproductive outcomes of in vitro fertilization patients diagnosed with endometriosis and compared to controls without endometriosis.\n\nDesign: This is a retrospective cohort study on prospectively collected data.\n\nSetting: The study was conducted at tertiary care university hospital.\n\nParticipants: Participants were infertile women with histopathological diagnosis of endometriosis.\n\nMethods: For 12 months (January 2018 to January 2019), women were deemed suitable and subsequently divided according to serum TSH levels above or below 2.5 mIU/L and compared to patients without endometriosis. Needed sample size was at least 41 patients for each cohort of women. Co-primary outcomes were the live birth rate (LBR), clinical pregnancy rate (CPR), and pregnancy loss rate (PLR).\n\nResults: Overall, 226 women (45 with endometriosis and 181 controls without endometriosis) were included. Diagnoses of Hashimoto thyroiditis were significantly more frequent in women with rather than without endometriosis (14/45 [31.1%] vs. 27/181 [14.9%]; p = 0.012). Similarly, in women with endometriosis, Hashimoto diagnosis rates were higher with TSH ≥2.5 mIU/L compared to TSH \u0026lt;2.5 mIU/L (9/15 [60%] vs.5/30 [16.6%]; p = 0.001) so were the Hashimoto diagnosis rates in control group (women without endometriosis) with TSH ≥2.5 mIU/L compared to TSH \u0026lt;2.5 mIU/L (17/48 [35.4%] vs. 10/133 [7.5%], respectively; p = 0.001). Effect size analysis confirmed an increased risk of Hashimoto thyroiditis in women with endometriosis and TSH ≥2.5 mIU/L compared to women with endometriosis and TSH \u0026lt;2.5 mIU/L (risk ratio [RR] 3.60 [95% CI 1.46-8.86]) and in women with endometriosis and TSH ≥2.5 mIU/L compared to non-endometriotic euthyroid patients (RR 7.98 [95% CI 3.86-16.48]). Dysmenorrhea risk was higher in endometriotic euthyroid women compared to euthyroid patients with no endometriosis (RR 1.87 [95% CI 1.21-2.87]). The risk was still increased in euthyroid women with endometriosis relative to dysthyroid women with no endometriosis (RR 1.97 [95% CI 1.11-3.50]). There were no significant differences between the four groups for CPR, LBR, PLR and retrieved oocytes, immature oocytes, degenerated and unfertilized oocytes, cultured blastocysts, embryos and transferred embryos.\n\nLimitations: Limitations of the study were retrospective design, limited sample size, and use of different ovarian stimulation protocol.\n\nConclusions: Thyroid autoimmunity seems more common in women with endometriosis and TSH over 2.5 mIU/L. However, there was no significant impact on in vitro fertilization and reproductive outcomes related to the coexistence of endometriosis, Hashimoto disease, and higher TSH levels. Due to limitations of the study, additional evidence is required to validate the abovementioned findings.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Gynecologic and Obstetric Investigation"},"translated_abstract":"Objectives: The objective of the study was to evaluate the prevalence and impact of impaired thyroid-stimulating hormone (TSH) levels on the reproductive outcomes of in vitro fertilization patients diagnosed with endometriosis and compared to controls without endometriosis.\n\nDesign: This is a retrospective cohort study on prospectively collected data.\n\nSetting: The study was conducted at tertiary care university hospital.\n\nParticipants: Participants were infertile women with histopathological diagnosis of endometriosis.\n\nMethods: For 12 months (January 2018 to January 2019), women were deemed suitable and subsequently divided according to serum TSH levels above or below 2.5 mIU/L and compared to patients without endometriosis. Needed sample size was at least 41 patients for each cohort of women. Co-primary outcomes were the live birth rate (LBR), clinical pregnancy rate (CPR), and pregnancy loss rate (PLR).\n\nResults: Overall, 226 women (45 with endometriosis and 181 controls without endometriosis) were included. Diagnoses of Hashimoto thyroiditis were significantly more frequent in women with rather than without endometriosis (14/45 [31.1%] vs. 27/181 [14.9%]; p = 0.012). Similarly, in women with endometriosis, Hashimoto diagnosis rates were higher with TSH ≥2.5 mIU/L compared to TSH \u0026lt;2.5 mIU/L (9/15 [60%] vs.5/30 [16.6%]; p = 0.001) so were the Hashimoto diagnosis rates in control group (women without endometriosis) with TSH ≥2.5 mIU/L compared to TSH \u0026lt;2.5 mIU/L (17/48 [35.4%] vs. 10/133 [7.5%], respectively; p = 0.001). Effect size analysis confirmed an increased risk of Hashimoto thyroiditis in women with endometriosis and TSH ≥2.5 mIU/L compared to women with endometriosis and TSH \u0026lt;2.5 mIU/L (risk ratio [RR] 3.60 [95% CI 1.46-8.86]) and in women with endometriosis and TSH ≥2.5 mIU/L compared to non-endometriotic euthyroid patients (RR 7.98 [95% CI 3.86-16.48]). Dysmenorrhea risk was higher in endometriotic euthyroid women compared to euthyroid patients with no endometriosis (RR 1.87 [95% CI 1.21-2.87]). The risk was still increased in euthyroid women with endometriosis relative to dysthyroid women with no endometriosis (RR 1.97 [95% CI 1.11-3.50]). There were no significant differences between the four groups for CPR, LBR, PLR and retrieved oocytes, immature oocytes, degenerated and unfertilized oocytes, cultured blastocysts, embryos and transferred embryos.\n\nLimitations: Limitations of the study were retrospective design, limited sample size, and use of different ovarian stimulation protocol.\n\nConclusions: Thyroid autoimmunity seems more common in women with endometriosis and TSH over 2.5 mIU/L. However, there was no significant impact on in vitro fertilization and reproductive outcomes related to the coexistence of endometriosis, Hashimoto disease, and higher TSH levels. Due to limitations of the study, additional evidence is required to validate the abovementioned findings.","internal_url":"https://www.academia.edu/122353682/Coexistence_of_Endometriosis_and_Thyroid_Autoimmunity_in_Infertile_Women_Impact_on_in_vitro_Fertilization_and_Reproductive_Outcomes","translated_internal_url":"","created_at":"2024-07-25T22:04:12.371-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Coexistence_of_Endometriosis_and_Thyroid_Autoimmunity_in_Infertile_Women_Impact_on_in_vitro_Fertilization_and_Reproductive_Outcomes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"RGU3clJ0SXBBRVdiOWMrckdRSFdoaUMwaXhobWhwL3N3d0YyY0dYZng0TT0tLUo3cmRpb3VzYWdtbk1kNStqN3V4NXc9PQ==--e61d07bbf160cfaa107a65208edb9a5e0c1c5818"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":25630,"name":"Endocrinology \u0026 Metabolism","url":"https://www.academia.edu/Documents/in/Endocrinology_and_Metabolism"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"}],"urls":[{"id":43688843,"url":"https://karger.com/goi/article/doi/10.1159/000539265/907088/Coexistence-of-Endometriosis-and-Thyroid"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122244986"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122244986/Reproductive_Outcomes_in_Young_Women_with_Early_Stage_Cervical_Cancer_Greater_Than_2_cm_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review"><img alt="Research paper thumbnail of Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater Than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review" class="work-thumbnail" src="https://attachments.academia-assets.com/116952161/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122244986/Reproductive_Outcomes_in_Young_Women_with_Early_Stage_Cervical_Cancer_Greater_Than_2_cm_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review">Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater Than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review</a></div><div class="wp-workCard_item"><span>Medicina</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background and Objectives: Despite advancements in detection and treatment, cervical cancer remai...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background and Objectives: Despite advancements in detection and treatment, cervical cancer remains a significant health concern, particularly among young women of reproductive age. Limited data exists in the literature regarding fertility-sparing treatment (FST) of cervical cancers with tumor sizes greater than 2 cm. The objective of this systematic review was to evaluate the reproductive outcomes of women diagnosed with cervical cancer greater than 2 cm who underwent FST. Materials and Methods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies (retrospective or prospective) that reported reproductive outcomes of patients with cervical cancer >2 cm were considered eligible for inclusion in this systematic review (CRD42024521964). Studies describing only the oncologic outcomes, involving FST for cervical cancers less than 2 cm in size, and case reports were excluded. Results: Seventeen papers that met the abovementioned inclusion criteria were included in the present systematic review. In total, 443 patients with a cervical cancer larger than 2 cm were included in this systematic review. Eighty pregnancies occurred, with 24 miscarriages and 54 live births. Conclusions: FST appears to be a viable option for women of childbearing age diagnosed with cervical cancer larger than 2 cm. However, careful consideration is advised in interpreting these encouraging results, as they are subject to limitations, such as variability in study designs and potential biases. In addition, reproductive outcomes should be further cross-referenced with oncologic outcomes to clarify the potential risk-benefit ratio. It is critical to conduct further research using standardized approaches and larger participant groups to strengthen the validity of the conclusions drawn.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="19043a2be8763b37073d7ef31ffe1cec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116952161,"asset_id":122244986,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116952161/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122244986"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122244986"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122244986; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122244986]").text(description); $(".js-view-count[data-work-id=122244986]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122244986; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122244986']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122244986, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "19043a2be8763b37073d7ef31ffe1cec" } } $('.js-work-strip[data-work-id=122244986]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122244986,"title":"Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater Than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review","translated_title":"","metadata":{"doi":"10.3390/medicina60040608","abstract":"Background and Objectives: Despite advancements in detection and treatment, cervical cancer remains a significant health concern, particularly among young women of reproductive age. Limited data exists in the literature regarding fertility-sparing treatment (FST) of cervical cancers with tumor sizes greater than 2 cm. The objective of this systematic review was to evaluate the reproductive outcomes of women diagnosed with cervical cancer greater than 2 cm who underwent FST. Materials and Methods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies (retrospective or prospective) that reported reproductive outcomes of patients with cervical cancer \u003e2 cm were considered eligible for inclusion in this systematic review (CRD42024521964). Studies describing only the oncologic outcomes, involving FST for cervical cancers less than 2 cm in size, and case reports were excluded. Results: Seventeen papers that met the abovementioned inclusion criteria were included in the present systematic review. In total, 443 patients with a cervical cancer larger than 2 cm were included in this systematic review. Eighty pregnancies occurred, with 24 miscarriages and 54 live births. Conclusions: FST appears to be a viable option for women of childbearing age diagnosed with cervical cancer larger than 2 cm. However, careful consideration is advised in interpreting these encouraging results, as they are subject to limitations, such as variability in study designs and potential biases. In addition, reproductive outcomes should be further cross-referenced with oncologic outcomes to clarify the potential risk-benefit ratio. It is critical to conduct further research using standardized approaches and larger participant groups to strengthen the validity of the conclusions drawn.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Medicina"},"translated_abstract":"Background and Objectives: Despite advancements in detection and treatment, cervical cancer remains a significant health concern, particularly among young women of reproductive age. Limited data exists in the literature regarding fertility-sparing treatment (FST) of cervical cancers with tumor sizes greater than 2 cm. The objective of this systematic review was to evaluate the reproductive outcomes of women diagnosed with cervical cancer greater than 2 cm who underwent FST. Materials and Methods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies (retrospective or prospective) that reported reproductive outcomes of patients with cervical cancer \u003e2 cm were considered eligible for inclusion in this systematic review (CRD42024521964). Studies describing only the oncologic outcomes, involving FST for cervical cancers less than 2 cm in size, and case reports were excluded. Results: Seventeen papers that met the abovementioned inclusion criteria were included in the present systematic review. In total, 443 patients with a cervical cancer larger than 2 cm were included in this systematic review. Eighty pregnancies occurred, with 24 miscarriages and 54 live births. Conclusions: FST appears to be a viable option for women of childbearing age diagnosed with cervical cancer larger than 2 cm. However, careful consideration is advised in interpreting these encouraging results, as they are subject to limitations, such as variability in study designs and potential biases. In addition, reproductive outcomes should be further cross-referenced with oncologic outcomes to clarify the potential risk-benefit ratio. It is critical to conduct further research using standardized approaches and larger participant groups to strengthen the validity of the conclusions drawn.","internal_url":"https://www.academia.edu/122244986/Reproductive_Outcomes_in_Young_Women_with_Early_Stage_Cervical_Cancer_Greater_Than_2_cm_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review","translated_internal_url":"","created_at":"2024-07-21T22:55:48.554-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":42093261,"work_id":122244986,"tagging_user_id":12242463,"tagged_user_id":276916122,"co_author_invite_id":null,"email":"a***9@libero.it","display_order":1,"name":"Antonio D’Amato","title":"Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater Than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122056566"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122056566/Isthmocele_and_Infertility"><img alt="Research paper thumbnail of Isthmocele and Infertility" class="work-thumbnail" src="https://attachments.academia-assets.com/116795252/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122056566/Isthmocele_and_Infertility">Isthmocele and Infertility</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AngelucciCecilia">Cecilia Angelucci</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AndreaTinelli2">Andrea Tinelli</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GiorgioBaldini4">Giorgio Baldini</a></span></div><div class="wp-workCard_item"><span>Journal of Clinical Medicine</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or insufficient healing of the uterine wall following a cesarean incision. It appears that isthmocele may impact a woman's quality of life as well as her reproductive capacity. The incidence of isthmocele can range from 20% to 70% in women who have undergone a cesarean section. This review aims to sum up the current knowledge about the effect of isthmocele on fertility and the possible therapeutic strategies to achieve pregnancy. However, currently, there is not sufficiently robust evidence to indicate the need for surgical correction in all asymptomatic patients seeking fertility. In cases where surgical correction of isthmocele is deemed necessary, it is advisable to evaluate residual myometrial thickness (RMT). For patients with RMT >2.5-3 mm, hysteroscopy appears to be the technique of choice. In cases where the residual tissue is lower, recourse to laparotomic, laparoscopic, or vaginal approaches is warranted.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2b1b288d3796102cb7624ddbcd7363bc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116795252,"asset_id":122056566,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116795252/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122056566"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122056566"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122056566; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122056566]").text(description); $(".js-view-count[data-work-id=122056566]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122056566; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122056566']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122056566, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2b1b288d3796102cb7624ddbcd7363bc" } } $('.js-work-strip[data-work-id=122056566]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122056566,"title":"Isthmocele and Infertility","translated_title":"","metadata":{"doi":"10.3390/jcm13082192","abstract":"Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or insufficient healing of the uterine wall following a cesarean incision. It appears that isthmocele may impact a woman's quality of life as well as her reproductive capacity. The incidence of isthmocele can range from 20% to 70% in women who have undergone a cesarean section. This review aims to sum up the current knowledge about the effect of isthmocele on fertility and the possible therapeutic strategies to achieve pregnancy. However, currently, there is not sufficiently robust evidence to indicate the need for surgical correction in all asymptomatic patients seeking fertility. In cases where surgical correction of isthmocele is deemed necessary, it is advisable to evaluate residual myometrial thickness (RMT). For patients with RMT \u003e2.5-3 mm, hysteroscopy appears to be the technique of choice. In cases where the residual tissue is lower, recourse to laparotomic, laparoscopic, or vaginal approaches is warranted.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Journal of Clinical Medicine"},"translated_abstract":"Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or insufficient healing of the uterine wall following a cesarean incision. It appears that isthmocele may impact a woman's quality of life as well as her reproductive capacity. The incidence of isthmocele can range from 20% to 70% in women who have undergone a cesarean section. This review aims to sum up the current knowledge about the effect of isthmocele on fertility and the possible therapeutic strategies to achieve pregnancy. However, currently, there is not sufficiently robust evidence to indicate the need for surgical correction in all asymptomatic patients seeking fertility. In cases where surgical correction of isthmocele is deemed necessary, it is advisable to evaluate residual myometrial thickness (RMT). For patients with RMT \u003e2.5-3 mm, hysteroscopy appears to be the technique of choice. 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href="https://www.academia.edu/122035235/Impact_of_Thrombophilic_Polymorphisms_in_Antenatal_Women_on_Perinatal_Health_A_Single_Center_Prospective_Study"><img alt="Research paper thumbnail of Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study" class="work-thumbnail" src="https://attachments.academia-assets.com/116778595/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122035235/Impact_of_Thrombophilic_Polymorphisms_in_Antenatal_Women_on_Perinatal_Health_A_Single_Center_Prospective_Study">Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study</a></div><div class="wp-workCard_item"><span>Journal of Personalized Medicine</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Despite pregnancy's hypercoagulable state, the correlation between inherited thrombop...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Despite pregnancy's hypercoagulable state, the correlation between inherited thrombophilia and thrombotic adverse pregnancy outcomes remains uncertain. The objective of this study was to determine the prevalence of inherited thrombophilic polymorphisms among asymptomatic pregnant individuals and to examine their potential correlation with adverse perinatal outcomes. Methods: in this single-center prospective study, 105 healthy pregnant women were included. Genotyping was conducted for factor V Leiden (FVL), prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, and plasminogen activator inhibitor-1 (PAI-1), alongside the assessment of protein C (PC), protein S (PS), and antithrombin (AT) levels. The study analyzed the association between inherited thrombophilic polymorphisms and pregnancy complications linked to placental insufficiency, such as gestational hypertension (GH), preeclampsia (PE), intrauterine death (IUD), fetal growth restriction (FGR), and placental abruption. Results: The prevalence of identifiable thrombophilic polymorphism mutations was 61.9% (95% confidence interval-CI 52.4-70.8%), with the most common single mutation being PAI-1 4G/5G (12/105, 11.4%, 95% CI 6.4-18.5). The most frequent combined mutation was heterozygosity for MTHFR C677T and PAI-1 (12/105, 11.4%, 95% CI 6.4-18.5). Notably, no FVL homozygous carriers or single homozygous and heterozygous carriers for prothrombin polymorphisms were found. Additionally, no deficiencies in PC and AT were detected among participants. Except for homozygosity for PAI-1, none of the studied polymorphisms demonstrated a significant association with pregnancy complications linked to placental insufficiency. Conclusions: The asymptomatic carriers of inherited thrombophilic polymorphisms do not have an increased risk of adverse perinatal outcomes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aa51c4cfe3462d6f69193cc2717ae51f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116778595,"asset_id":122035235,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116778595/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122035235"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122035235"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122035235; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122035235]").text(description); $(".js-view-count[data-work-id=122035235]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122035235; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122035235']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122035235, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aa51c4cfe3462d6f69193cc2717ae51f" } } $('.js-work-strip[data-work-id=122035235]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122035235,"title":"Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study","translated_title":"","metadata":{"doi":"10.3390/jpm14040433","abstract":"Background: Despite pregnancy's hypercoagulable state, the correlation between inherited thrombophilia and thrombotic adverse pregnancy outcomes remains uncertain. The objective of this study was to determine the prevalence of inherited thrombophilic polymorphisms among asymptomatic pregnant individuals and to examine their potential correlation with adverse perinatal outcomes. Methods: in this single-center prospective study, 105 healthy pregnant women were included. Genotyping was conducted for factor V Leiden (FVL), prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, and plasminogen activator inhibitor-1 (PAI-1), alongside the assessment of protein C (PC), protein S (PS), and antithrombin (AT) levels. The study analyzed the association between inherited thrombophilic polymorphisms and pregnancy complications linked to placental insufficiency, such as gestational hypertension (GH), preeclampsia (PE), intrauterine death (IUD), fetal growth restriction (FGR), and placental abruption. Results: The prevalence of identifiable thrombophilic polymorphism mutations was 61.9% (95% confidence interval-CI 52.4-70.8%), with the most common single mutation being PAI-1 4G/5G (12/105, 11.4%, 95% CI 6.4-18.5). The most frequent combined mutation was heterozygosity for MTHFR C677T and PAI-1 (12/105, 11.4%, 95% CI 6.4-18.5). Notably, no FVL homozygous carriers or single homozygous and heterozygous carriers for prothrombin polymorphisms were found. Additionally, no deficiencies in PC and AT were detected among participants. Except for homozygosity for PAI-1, none of the studied polymorphisms demonstrated a significant association with pregnancy complications linked to placental insufficiency. Conclusions: The asymptomatic carriers of inherited thrombophilic polymorphisms do not have an increased risk of adverse perinatal outcomes.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Journal of Personalized Medicine"},"translated_abstract":"Background: Despite pregnancy's hypercoagulable state, the correlation between inherited thrombophilia and thrombotic adverse pregnancy outcomes remains uncertain. The objective of this study was to determine the prevalence of inherited thrombophilic polymorphisms among asymptomatic pregnant individuals and to examine their potential correlation with adverse perinatal outcomes. Methods: in this single-center prospective study, 105 healthy pregnant women were included. Genotyping was conducted for factor V Leiden (FVL), prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, and plasminogen activator inhibitor-1 (PAI-1), alongside the assessment of protein C (PC), protein S (PS), and antithrombin (AT) levels. The study analyzed the association between inherited thrombophilic polymorphisms and pregnancy complications linked to placental insufficiency, such as gestational hypertension (GH), preeclampsia (PE), intrauterine death (IUD), fetal growth restriction (FGR), and placental abruption. Results: The prevalence of identifiable thrombophilic polymorphism mutations was 61.9% (95% confidence interval-CI 52.4-70.8%), with the most common single mutation being PAI-1 4G/5G (12/105, 11.4%, 95% CI 6.4-18.5). The most frequent combined mutation was heterozygosity for MTHFR C677T and PAI-1 (12/105, 11.4%, 95% CI 6.4-18.5). Notably, no FVL homozygous carriers or single homozygous and heterozygous carriers for prothrombin polymorphisms were found. Additionally, no deficiencies in PC and AT were detected among participants. Except for homozygosity for PAI-1, none of the studied polymorphisms demonstrated a significant association with pregnancy complications linked to placental insufficiency. 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and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122005009"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122005009/Can_the_endometrioma_be_an_obstacle_to_complete_oocyte_retrieval_in_IVF_cycles_A_retrospective_study"><img alt="Research paper thumbnail of Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study" class="work-thumbnail" src="https://attachments.academia-assets.com/116755062/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122005009/Can_the_endometrioma_be_an_obstacle_to_complete_oocyte_retrieval_in_IVF_cycles_A_retrospective_study">Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/BaldiniDomenico">Domenico Baldini</a></span></div><div class="wp-workCard_item"><span>European Review for Medical and Pharmacological Sciences</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The study aimed to evaluate the utility and safety of ancillary maneuvers during oocyte retrieval...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The study aimed to evaluate the utility and safety of ancillary maneuvers during oocyte retrieval for patients with endometrioma that makes ovum pickup hard due to poor ovarian surgical accessibility. PATIENTS AND METHODS: Cases of 251 women with ovarian endometriomas undergoing in vitro fertilization (IVF) in our infertility unit were retrospectively analyzed to evaluate the clinical IVF cycle outcomes after oocyte retrieval. Controls (n = 251) were age-matched women without endometriomas who underwent an uncomplicated oocyte retrieval. RESULTS: No statistically significant differences were observed between groups except for the number of oocytes retrieved, which was higher in the control group than in the group of women with endometrioma. On the contrary, there were no differences between the experimental groups in the fertilization rate and number of embryos and neither were there in the pregnancy and live birth rate. Moreover, the surgical complications were infrequent and similar between the two analyzed groups. Accidental or voluntary endometrioma punctures were not accompanied by increases in the risk of a pelvic infection. CONCLUSIONS: In conclusion, patients with endometrioma can undergo high-performance oocyte recovery procedures thanks to safe accessory maneuvers during the ovum pickup .</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="87a827f8807a1f4e5d54cdd8dc26df61" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116755062,"asset_id":122005009,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116755062/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122005009"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122005009"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122005009; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122005009]").text(description); $(".js-view-count[data-work-id=122005009]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122005009; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122005009']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 122005009, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "87a827f8807a1f4e5d54cdd8dc26df61" } } $('.js-work-strip[data-work-id=122005009]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122005009,"title":"Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? 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On the contrary, there were no differences between the experimental groups in the fertilization rate and number of embryos and neither were there in the pregnancy and live birth rate. Moreover, the surgical complications were infrequent and similar between the two analyzed groups. Accidental or voluntary endometrioma punctures were not accompanied by increases in the risk of a pelvic infection. CONCLUSIONS: In conclusion, patients with endometrioma can undergo high-performance oocyte recovery procedures thanks to safe accessory maneuvers during the ovum pickup .","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"European Review for Medical and Pharmacological Sciences"},"translated_abstract":"The study aimed to evaluate the utility and safety of ancillary maneuvers during oocyte retrieval for patients with endometrioma that makes ovum pickup hard due to poor ovarian surgical accessibility. PATIENTS AND METHODS: Cases of 251 women with ovarian endometriomas undergoing in vitro fertilization (IVF) in our infertility unit were retrospectively analyzed to evaluate the clinical IVF cycle outcomes after oocyte retrieval. Controls (n = 251) were age-matched women without endometriomas who underwent an uncomplicated oocyte retrieval. RESULTS: No statistically significant differences were observed between groups except for the number of oocytes retrieved, which was higher in the control group than in the group of women with endometrioma. On the contrary, there were no differences between the experimental groups in the fertilization rate and number of embryos and neither were there in the pregnancy and live birth rate. Moreover, the surgical complications were infrequent and similar between the two analyzed groups. Accidental or voluntary endometrioma punctures were not accompanied by increases in the risk of a pelvic infection. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121668801"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121668801/Early_pregnancy_bleeding_after_assisted_reproductive_technology_a_common_adverse_event_that_does_not_always_affect_reproductive_outcome"><img alt="Research paper thumbnail of Early pregnancy bleeding after assisted reproductive technology: a common adverse event that does not always affect reproductive outcome" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121668801/Early_pregnancy_bleeding_after_assisted_reproductive_technology_a_common_adverse_event_that_does_not_always_affect_reproductive_outcome">Early pregnancy bleeding after assisted reproductive technology: a common adverse event that does not always affect reproductive outcome</a></div><div class="wp-workCard_item"><span>Evidence-Based Nursing</span><span>, 2024</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121668801"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121668801"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121668801; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121551856"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121551856/Analogies_between_HPV_Behavior_in_Oral_and_Vaginal_Cavity_Narrative_Review_on_the_Current_Evidence_in_the_Literature"><img alt="Research paper thumbnail of Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature" class="work-thumbnail" src="https://attachments.academia-assets.com/116397834/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121551856/Analogies_between_HPV_Behavior_in_Oral_and_Vaginal_Cavity_Narrative_Review_on_the_Current_Evidence_in_the_Literature">Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature</a></div><div class="wp-workCard_item"><span>Journal of Clinical Medicine</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Human genital papilloma virus infection is the most prevalent sexually transmitted infection in t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. It is estimated that more than 75% of sexually active women contract this infection in their lifetime. In 80% of young women, there is the clearance of the virus within 18-24 months. In developed countries, oral squamous cell carcinoma (OSCC) is now the most frequent human papilloma virus (HPV)-related cancer, having surpassed cervical cancer, and it is predicted that by 2030 most squamous cell carcinomas will be the HPV-related rather than non-HPV-related form. However, there are currently no screening programs for oral cavity infection. While the natural history of HPV infection in the cervix is well known, in the oropharynx, it is not entirely clear. Furthermore, the prevalence of HPV in the oropharynx is unknown. Published studies have found wide-ranging prevalence estimates of 2.6% to 50%. There are also conflicting results regarding the percentage of women presenting the same type of HPV at two mucosal sites, ranging from 0 to 60%. Additionally, the question arises as to whether oral infection can develop from genital HPV infection, through oral and genital contact or by self-inoculation, or whether it should be considered an independent event. However, there is still no consensus on these topics, nor on the relationship between genital and oral HPV infections. Therefore, this literature review aims to evaluate whether there is evidence of a connection between oral and cervical HPV, while also endorsing the usefulness of the screening of oral infection in patients with high-risk cervical HPV as a means of facilitating the diagnosis and early management of HPV-related oral lesions. Finally, this review emphasizes the recommendation for the use of the HPV vaccines in primary prevention in the male and female population as the most effective means of successfully counteracting the increasing incidence of OSCC to date.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7aa68f4b8b2c9a2579b3044d1df308d1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116397834,"asset_id":121551856,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116397834/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121551856"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121551856"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121551856; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121551856]").text(description); $(".js-view-count[data-work-id=121551856]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121551856; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121551856']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121551856, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7aa68f4b8b2c9a2579b3044d1df308d1" } } $('.js-work-strip[data-work-id=121551856]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121551856,"title":"Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature","translated_title":"","metadata":{"doi":"10.3390/jcm13051429","abstract":"Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121433831"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121433831/The_great_debate_Surgical_outcomes_of_laparoscopic_versus_laparotomic_myomectomy_A_meta_analysis_to_critically_evaluate_current_evidence_and_look_over_the_horizon"><img alt="Research paper thumbnail of The great debate: Surgical outcomes of laparoscopic versus laparotomic myomectomy. A meta-analysis to critically evaluate current evidence and look over the horizon" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121433831/The_great_debate_Surgical_outcomes_of_laparoscopic_versus_laparotomic_myomectomy_A_meta_analysis_to_critically_evaluate_current_evidence_and_look_over_the_horizon">The great debate: Surgical outcomes of laparoscopic versus laparotomic myomectomy. A meta-analysis to critically evaluate current evidence and look over the horizon</a></div><div class="wp-workCard_item"><span>European Journal of Obstetrics & Gynecology and Reproductive Biology</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Myomectomy is one of the most common surgical procedure in the field of gynecology. However, the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Myomectomy is one of the most common surgical procedure in the field of gynecology. However, the role of laparoscopic myomectomy is still debated for many factors, including surgical considerations, safety and fertility concerns, long-term outcomes, and cost-related issues. The aim of this study is to evaluate the surgical peri- and post-operative outcomes of laparoscopic and abdominal myomectomy. A systematic search for studies was performed up to June 2023 through MEDLINE, Pubmed, Embase. Studies reporting the comparison of surgical and obstetrical outcomes in laparoscopic versus laparotomic myomectomy were included for the following outcomes: time of surgery, estimated blood loss, decrease of postoperative hemoglobin, hospital stay, intra-operative complication rates, postoperative complications rates, postoperative analgesic use, postoperative pain at 24 h and pregnancy rate. The meta-analysis was performed using the Cochrane Review software. Fifty-six relevant articles were retrieved through the process of evidence acquisition. Eleven articles met inclusion criteria, for a total of 2,133 patients undergoing laparoscopic or laparotomic myomectomy. The estimated blood loss [standard mean differences (SMD) 0.72, IC 95 % 0.22 to 1.22], the hospital stays [SMD 3.12, IC 95 % 0.57 to 4.28], were significantly lower in laparoscopic than in open group. No statistically significant difference in intra-operative and post-operative complication rates, in pregnancy rate and others obstetrical outcomes between two surgical approaches were found. The findings of present metanalysis suggest that laparoscopic myomectomy offers multiple benefits, including reduced blood loss, shorter hospital stays, and less postoperative analgesic need, without a significant increase in complication rates and similar results in obstetrical outcomes when compared to abdominal myomectomy. However, the presence of few randomized studies on selected population may limit the generalizability of the findings to the entire population. Therefore, more well-designed studies or large population programdata to draw definitive conclusions are therefore warranted.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121433831"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121433831"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121433831; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121433831]").text(description); $(".js-view-count[data-work-id=121433831]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121433831; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121433831']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121433831, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121433831]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121433831,"title":"The great debate: Surgical outcomes of laparoscopic versus laparotomic myomectomy. A meta-analysis to critically evaluate current evidence and look over the horizon","translated_title":"","metadata":{"doi":"10.1016/j.ejogrb.2024.03.045","abstract":"Myomectomy is one of the most common surgical procedure in the field of gynecology. However, the role of laparoscopic myomectomy is still debated for many factors, including surgical considerations, safety and fertility concerns, long-term outcomes, and cost-related issues. The aim of this study is to evaluate the surgical peri- and post-operative outcomes of laparoscopic and abdominal myomectomy. A systematic search for studies was performed up to June 2023 through MEDLINE, Pubmed, Embase. Studies reporting the comparison of surgical and obstetrical outcomes in laparoscopic versus laparotomic myomectomy were included for the following outcomes: time of surgery, estimated blood loss, decrease of postoperative hemoglobin, hospital stay, intra-operative complication rates, postoperative complications rates, postoperative analgesic use, postoperative pain at 24 h and pregnancy rate. The meta-analysis was performed using the Cochrane Review software. Fifty-six relevant articles were retrieved through the process of evidence acquisition. Eleven articles met inclusion criteria, for a total of 2,133 patients undergoing laparoscopic or laparotomic myomectomy. The estimated blood loss [standard mean differences (SMD) 0.72, IC 95 % 0.22 to 1.22], the hospital stays [SMD 3.12, IC 95 % 0.57 to 4.28], were significantly lower in laparoscopic than in open group. No statistically significant difference in intra-operative and post-operative complication rates, in pregnancy rate and others obstetrical outcomes between two surgical approaches were found. The findings of present metanalysis suggest that laparoscopic myomectomy offers multiple benefits, including reduced blood loss, shorter hospital stays, and less postoperative analgesic need, without a significant increase in complication rates and similar results in obstetrical outcomes when compared to abdominal myomectomy. However, the presence of few randomized studies on selected population may limit the generalizability of the findings to the entire population. Therefore, more well-designed studies or large population programdata to draw definitive conclusions are therefore warranted.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"European Journal of Obstetrics \u0026 Gynecology and Reproductive Biology"},"translated_abstract":"Myomectomy is one of the most common surgical procedure in the field of gynecology. However, the role of laparoscopic myomectomy is still debated for many factors, including surgical considerations, safety and fertility concerns, long-term outcomes, and cost-related issues. The aim of this study is to evaluate the surgical peri- and post-operative outcomes of laparoscopic and abdominal myomectomy. A systematic search for studies was performed up to June 2023 through MEDLINE, Pubmed, Embase. Studies reporting the comparison of surgical and obstetrical outcomes in laparoscopic versus laparotomic myomectomy were included for the following outcomes: time of surgery, estimated blood loss, decrease of postoperative hemoglobin, hospital stay, intra-operative complication rates, postoperative complications rates, postoperative analgesic use, postoperative pain at 24 h and pregnancy rate. The meta-analysis was performed using the Cochrane Review software. Fifty-six relevant articles were retrieved through the process of evidence acquisition. Eleven articles met inclusion criteria, for a total of 2,133 patients undergoing laparoscopic or laparotomic myomectomy. The estimated blood loss [standard mean differences (SMD) 0.72, IC 95 % 0.22 to 1.22], the hospital stays [SMD 3.12, IC 95 % 0.57 to 4.28], were significantly lower in laparoscopic than in open group. No statistically significant difference in intra-operative and post-operative complication rates, in pregnancy rate and others obstetrical outcomes between two surgical approaches were found. The findings of present metanalysis suggest that laparoscopic myomectomy offers multiple benefits, including reduced blood loss, shorter hospital stays, and less postoperative analgesic need, without a significant increase in complication rates and similar results in obstetrical outcomes when compared to abdominal myomectomy. However, the presence of few randomized studies on selected population may limit the generalizability of the findings to the entire population. Therefore, more well-designed studies or large population programdata to draw definitive conclusions are therefore warranted.","internal_url":"https://www.academia.edu/121433831/The_great_debate_Surgical_outcomes_of_laparoscopic_versus_laparotomic_myomectomy_A_meta_analysis_to_critically_evaluate_current_evidence_and_look_over_the_horizon","translated_internal_url":"","created_at":"2024-06-23T22:06:38.925-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_great_debate_Surgical_outcomes_of_laparoscopic_versus_laparotomic_myomectomy_A_meta_analysis_to_critically_evaluate_current_evidence_and_look_over_the_horizon","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"NXF2bjZMV3BnQkVURzdOa2s4MkJoSlcwMGdsZWxhcXdsQUs1UUFLZ3lWaz0tLURObE4ra2JmUWRybHBhTDV1SHc0ZUE9PQ==--acb24a89d0a6f863e493a7e0ccc488fb673027d1"},"attachments":[],"research_interests":[{"id":618,"name":"Gynaecology","url":"https://www.academia.edu/Documents/in/Gynaecology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"},{"id":1584584,"name":"Obgyn and Gynecology","url":"https://www.academia.edu/Documents/in/Obgyn_and_Gynecology"}],"urls":[{"id":43189148,"url":"https://pubmed.ncbi.nlm.nih.gov/38581885/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120760515"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120760515/Effect_of_maternal_age_and_BMI_on_induction_of_labor_using_oral_misoprostol_in_late_term_pregnancies_a_retrospective_cross_sectional_study"><img alt="Research paper thumbnail of Effect of maternal age and BMI on induction of labor using oral misoprostol in late-term pregnancies: a retrospective cross-sectional study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120760515/Effect_of_maternal_age_and_BMI_on_induction_of_labor_using_oral_misoprostol_in_late_term_pregnancies_a_retrospective_cross_sectional_study">Effect of maternal age and BMI on induction of labor using oral misoprostol in late-term pregnancies: a retrospective cross-sectional study</a></div><div class="wp-workCard_item"><span>Gynecologic and Obstetric Investigation</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: To evaluate the effect of maternal age and body mass index (BMI) on oral misoprostol ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: To evaluate the effect of maternal age and body mass index (BMI) on oral misoprostol induction of labor for late-term pregnancies.<br /><br />Design: Retrospective cross-sectional study (ClinicalTrial iD: NCT06184139), including only late-term pregnancies in healthy nulliparous women and single cephalic fetus with normal birthweight. Specify the type of study (randomized, prospective cohort, case-control, other) and include the number of study subjects (cases/controls), treatment type and duration, sampling procedures if applicable.<br /><br />Participants/materials, setting, methods: One-hundred-and-four pregnant women underwent induction of labor with oral misoprostol for late-term pregnancy on the 290th day of gestation. Study population was divided in two groups based on age (<35 and ≥35 years) and obesity (BMI <30 and ≥30). Statistical analysis was performed using SPSS V.21.0 (IBM Corporation, Armonk, NY). The inclusion of 51 women from each of the two arms achieved 80% power with an alpha error of 0.05. Continuous variables were expressed as the mean and standard deviation (SD). Categorical variables are expressed as frequencies and percentages. Results No statistically significant differences were recorded between younger and older women. Obese women reported a longer time between the last dose of misoprostol and cervical dilation of 6 cm (p=0.01), a longer time between the last dose of misoprostol and delivery (p=0.04), and a higher rate of grade II vaginal lacerations (p=0.02). Limitations While this study contributes novel insights into cervical ripening and labor induction using oral misoprostol for late-term pregnancies, its scope is limited by the retrospective study design, inherently carrying biases compared to prospective approaches, and the limited sample size within the study cohort. Conclusions Maternal BMI is a factor negatively influencing the efficacy of oral misoprostol for induction of labor in late-term pregnancy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120760515"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120760515"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120760515; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120760515]").text(description); $(".js-view-count[data-work-id=120760515]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120760515; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120760515']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 120760515, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120760515]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120760515,"title":"Effect of maternal age and BMI on induction of labor using oral misoprostol in late-term pregnancies: a retrospective cross-sectional study","translated_title":"","metadata":{"doi":"10.1159/000538374","abstract":"Objectives: To evaluate the effect of maternal age and body mass index (BMI) on oral misoprostol induction of labor for late-term pregnancies.\n\nDesign: Retrospective cross-sectional study (ClinicalTrial iD: NCT06184139), including only late-term pregnancies in healthy nulliparous women and single cephalic fetus with normal birthweight. Specify the type of study (randomized, prospective cohort, case-control, other) and include the number of study subjects (cases/controls), treatment type and duration, sampling procedures if applicable.\n\nParticipants/materials, setting, methods: One-hundred-and-four pregnant women underwent induction of labor with oral misoprostol for late-term pregnancy on the 290th day of gestation. Study population was divided in two groups based on age (\u003c35 and ≥35 years) and obesity (BMI \u003c30 and ≥30). Statistical analysis was performed using SPSS V.21.0 (IBM Corporation, Armonk, NY). The inclusion of 51 women from each of the two arms achieved 80% power with an alpha error of 0.05. Continuous variables were expressed as the mean and standard deviation (SD). Categorical variables are expressed as frequencies and percentages. Results No statistically significant differences were recorded between younger and older women. Obese women reported a longer time between the last dose of misoprostol and cervical dilation of 6 cm (p=0.01), a longer time between the last dose of misoprostol and delivery (p=0.04), and a higher rate of grade II vaginal lacerations (p=0.02). Limitations While this study contributes novel insights into cervical ripening and labor induction using oral misoprostol for late-term pregnancies, its scope is limited by the retrospective study design, inherently carrying biases compared to prospective approaches, and the limited sample size within the study cohort. Conclusions Maternal BMI is a factor negatively influencing the efficacy of oral misoprostol for induction of labor in late-term pregnancy.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Gynecologic and Obstetric Investigation"},"translated_abstract":"Objectives: To evaluate the effect of maternal age and body mass index (BMI) on oral misoprostol induction of labor for late-term pregnancies.\n\nDesign: Retrospective cross-sectional study (ClinicalTrial iD: NCT06184139), including only late-term pregnancies in healthy nulliparous women and single cephalic fetus with normal birthweight. Specify the type of study (randomized, prospective cohort, case-control, other) and include the number of study subjects (cases/controls), treatment type and duration, sampling procedures if applicable.\n\nParticipants/materials, setting, methods: One-hundred-and-four pregnant women underwent induction of labor with oral misoprostol for late-term pregnancy on the 290th day of gestation. Study population was divided in two groups based on age (\u003c35 and ≥35 years) and obesity (BMI \u003c30 and ≥30). Statistical analysis was performed using SPSS V.21.0 (IBM Corporation, Armonk, NY). The inclusion of 51 women from each of the two arms achieved 80% power with an alpha error of 0.05. Continuous variables were expressed as the mean and standard deviation (SD). Categorical variables are expressed as frequencies and percentages. Results No statistically significant differences were recorded between younger and older women. Obese women reported a longer time between the last dose of misoprostol and cervical dilation of 6 cm (p=0.01), a longer time between the last dose of misoprostol and delivery (p=0.04), and a higher rate of grade II vaginal lacerations (p=0.02). Limitations While this study contributes novel insights into cervical ripening and labor induction using oral misoprostol for late-term pregnancies, its scope is limited by the retrospective study design, inherently carrying biases compared to prospective approaches, and the limited sample size within the study cohort. Conclusions Maternal BMI is a factor negatively influencing the efficacy of oral misoprostol for induction of labor in late-term pregnancy.","internal_url":"https://www.academia.edu/120760515/Effect_of_maternal_age_and_BMI_on_induction_of_labor_using_oral_misoprostol_in_late_term_pregnancies_a_retrospective_cross_sectional_study","translated_internal_url":"","created_at":"2024-06-09T02:32:36.586-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_maternal_age_and_BMI_on_induction_of_labor_using_oral_misoprostol_in_late_term_pregnancies_a_retrospective_cross_sectional_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0","email":"Yjl2eENPWEk4VEFNMHFUL0xIWDBtVjc1WkVqR0pLSk5aY1hXZDJIR2pmbz0tLXdmSGFRVTAyWWhxdjh1MnkzRjJ5d3c9PQ==--b153db4046d26adec0a855eb1c196c56b1f814ae"},"attachments":[],"research_interests":[{"id":3770,"name":"Metabolism","url":"https://www.academia.edu/Documents/in/Metabolism"},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity"},{"id":25630,"name":"Endocrinology \u0026 Metabolism","url":"https://www.academia.edu/Documents/in/Endocrinology_and_Metabolism"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":126839,"name":"Obstetrics and Gynaecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_Gynaecology"},{"id":136590,"name":"Obstetrics and gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_and_gynecology"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":820310,"name":"Obsterics and Gynecology","url":"https://www.academia.edu/Documents/in/Obsterics_and_Gynecology"},{"id":1584584,"name":"Obgyn and Gynecology","url":"https://www.academia.edu/Documents/in/Obgyn_and_Gynecology"}],"urls":[{"id":42782625,"url":"https://pubmed.ncbi.nlm.nih.gov/38565086/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="118241104"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/118241104/Management_of_Uterine_Fibroids_and_Sarcomas_The_Palermo_Position_Paper"><img alt="Research paper thumbnail of Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper" class="work-thumbnail" src="https://attachments.academia-assets.com/113914032/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/118241104/Management_of_Uterine_Fibroids_and_Sarcomas_The_Palermo_Position_Paper">Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper</a></div><div class="wp-workCard_item"><span>Gynecologic and Obstetric Investigation</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cell...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cells of the myometrium, constituting the most prevalent pathology within the female genital tract. Uterine sarcomas, although rare, still represent a diagnostic challenge and should be managed in centers with adequate expertise in gynecological oncology.<br /><br />Objectives: This article is aimed to summarize and discuss cutting-edge elements about the diagnosis and management of uterine fibroids and sarcomas.<br /><br />Methods: This paper is a report of the lectures presented in an expert meeting about uterine fibroids and sarcomas held in Palermo in February 2023.<br /><br />Outcome: Overall, the combination of novel molecular pathways may help combine biomarkers and expert ultrasound for the differential diagnosis of uterine fibroids and sarcomas. On the one hand, molecular and cellular maps of uterine fibroids and matched myometrium may enhance our understanding of tumor development compared to histologic analysis and whole tissue transcriptomics, and support the development of minimally invasive treatment strategies; on the other hand, ultrasound imaging allows in most of the cases a proper mapping the fibroids and to differentiate between benign and malignant lesions, which need appropriate management.<br /><br />Conclusions and outlook: The choice of uterine fibroid management, including pharmacological approaches, surgical treatment, or other strategies, such as high-intensity focused ultrasound (HIFU), should be carefully considered, taking into account the characteristics of the patient and reproductive prognosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7044dd1ea07b1557785543406c7cacb9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113914032,"asset_id":118241104,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113914032/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="118241104"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="118241104"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 118241104; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=118241104]").text(description); $(".js-view-count[data-work-id=118241104]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 118241104; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='118241104']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 118241104, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7044dd1ea07b1557785543406c7cacb9" } } $('.js-work-strip[data-work-id=118241104]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":118241104,"title":"Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper","translated_title":"","metadata":{"doi":"10.1159/000537730","abstract":"Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cells of the myometrium, constituting the most prevalent pathology within the female genital tract. Uterine sarcomas, although rare, still represent a diagnostic challenge and should be managed in centers with adequate expertise in gynecological oncology.\n\nObjectives: This article is aimed to summarize and discuss cutting-edge elements about the diagnosis and management of uterine fibroids and sarcomas.\n\nMethods: This paper is a report of the lectures presented in an expert meeting about uterine fibroids and sarcomas held in Palermo in February 2023.\n\nOutcome: Overall, the combination of novel molecular pathways may help combine biomarkers and expert ultrasound for the differential diagnosis of uterine fibroids and sarcomas. On the one hand, molecular and cellular maps of uterine fibroids and matched myometrium may enhance our understanding of tumor development compared to histologic analysis and whole tissue transcriptomics, and support the development of minimally invasive treatment strategies; on the other hand, ultrasound imaging allows in most of the cases a proper mapping the fibroids and to differentiate between benign and malignant lesions, which need appropriate management.\n\nConclusions and outlook: The choice of uterine fibroid management, including pharmacological approaches, surgical treatment, or other strategies, such as high-intensity focused ultrasound (HIFU), should be carefully considered, taking into account the characteristics of the patient and reproductive prognosis.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Gynecologic and Obstetric Investigation"},"translated_abstract":"Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cells of the myometrium, constituting the most prevalent pathology within the female genital tract. Uterine sarcomas, although rare, still represent a diagnostic challenge and should be managed in centers with adequate expertise in gynecological oncology.\n\nObjectives: This article is aimed to summarize and discuss cutting-edge elements about the diagnosis and management of uterine fibroids and sarcomas.\n\nMethods: This paper is a report of the lectures presented in an expert meeting about uterine fibroids and sarcomas held in Palermo in February 2023.\n\nOutcome: Overall, the combination of novel molecular pathways may help combine biomarkers and expert ultrasound for the differential diagnosis of uterine fibroids and sarcomas. On the one hand, molecular and cellular maps of uterine fibroids and matched myometrium may enhance our understanding of tumor development compared to histologic analysis and whole tissue transcriptomics, and support the development of minimally invasive treatment strategies; on the other hand, ultrasound imaging allows in most of the cases a proper mapping the fibroids and to differentiate between benign and malignant lesions, which need appropriate management.\n\nConclusions and outlook: The choice of uterine fibroid management, including pharmacological approaches, surgical treatment, or other strategies, such as high-intensity focused ultrasound (HIFU), should be carefully considered, taking into account the characteristics of the patient and reproductive prognosis.","internal_url":"https://www.academia.edu/118241104/Management_of_Uterine_Fibroids_and_Sarcomas_The_Palermo_Position_Paper","translated_internal_url":"","created_at":"2024-04-28T22:10:50.226-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41580308,"work_id":118241104,"tagging_user_id":12242463,"tagged_user_id":null,"co_author_invite_id":7622721,"email":"a***a@unipa.it","display_order":1,"name":"Antonio Laganà","title":"Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper"},{"id":41580309,"work_id":118241104,"tagging_user_id":12242463,"tagged_user_id":38626512,"co_author_invite_id":null,"email":"m***e@uni-muenster.de","affiliation":"University of Münster","display_order":2,"name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117131259"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117131259/Prophylactic_Antibiotics_before_Gynecologic_Surgery_A_Comprehensive_Review_of_Guidelines"><img alt="Research paper thumbnail of Prophylactic Antibiotics before Gynecologic Surgery: A Comprehensive Review of Guidelines" class="work-thumbnail" src="https://attachments.academia-assets.com/113068650/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117131259/Prophylactic_Antibiotics_before_Gynecologic_Surgery_A_Comprehensive_Review_of_Guidelines">Prophylactic Antibiotics before Gynecologic Surgery: A Comprehensive Review of Guidelines</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/StamatiosPetousis">Stamatios Petousis</a></span></div><div class="wp-workCard_item"><span>Journal of Personalized Medicine</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Surgical site infections (SSIs) refer to infections in the incision, organ, or postoperative spac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Surgical site infections (SSIs) refer to infections in the incision, organ, or postoperative space. As common healthcare-associated infections, SSIs correlate with prolonged hospital stay, additional procedures, ICU stay, and higher mortality rates. Around 8-10% of gynecologic surgery patients may experience infectious complications, influenced by microbial contamination, surgical nature, and patient factors. The goal of this narrative review is to compare and merge recommendations from globally published guidelines concerning the utilization of antibiotics in the perioperative phase. A comparative descriptive/narrative review of the guidelines issued by the American College of Obstetrics and Gynecology (ACOG), Society of Obstetricians and Gynecologists of Canada (SOGC), Royal College of Obstetricians and Gynecologists (RCOG), National Institute for Health and Care Excellence (NICE), Royal Australian and New Zealand College of Obstetricians and Gynecologists (RANZCOG), European Society of Gynecologic Oncology (ESGO), Société Française d' Anésthesie et de Réanimation (SFAR), Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), and Hellenic Society of Obstetrics and Gynecology (HSOG) was conducted. For hysterectomy, first/second-generation cephalosporins are suggested, with metronidazole as an option. Laparoscopy without entering the bowel or vagina typically does not require prophylaxis. Uterine evacuation and hysteroscopy may involve doxycycline or azithromycin based on risk factors, whereas, for vulvectomy, cefazolin is recommended. Urogynecology procedures may include cefazolin with metronidazole. In cases of penicillin allergy, cephalosporins are suggested, and, for obese patients, adjusted doses are advised. Additional doses may be needed for prolonged procedures or excessive blood loss. Timing recommendations are 15-60 min before incision, adjusting for specific antibiotics. Clear indications exist for certain surgeries like hysterectomy, termination of pregnancy, and urogynecologic procedures. Conversely, procedures such as intrauterine device insertion, hysteroscopy, and laparoscopy typically do not necessitate antibiotic prophylaxis. For several other procedures, the evidence is inconclusive, while considering dose, timing, and indications can mitigate infectious complications and provide benefits for the healthcare system.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e50eeef0e8086c8ad5002206b3deb47e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113068650,"asset_id":117131259,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113068650/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117131259"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117131259"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117131259; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117131259]").text(description); $(".js-view-count[data-work-id=117131259]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117131259; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117131259']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117131259, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e50eeef0e8086c8ad5002206b3deb47e" } } $('.js-work-strip[data-work-id=117131259]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117131259,"title":"Prophylactic Antibiotics before Gynecologic Surgery: A Comprehensive Review of Guidelines","translated_title":"","metadata":{"doi":"10.3390/jpm14030327","abstract":"Surgical site infections (SSIs) refer to infections in the incision, organ, or postoperative space. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117089781"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117089781/Reproductive_and_Oncologic_Outcomes_in_Young_Women_with_Stage_IA_and_Grade_2_Endometrial_Carcinoma_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review"><img alt="Research paper thumbnail of Reproductive and Oncologic Outcomes in Young Women with Stage IA and Grade 2 Endometrial Carcinoma Undergoing Fertility-Sparing Treatment: A Systematic Review" class="work-thumbnail" src="https://attachments.academia-assets.com/113041225/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117089781/Reproductive_and_Oncologic_Outcomes_in_Young_Women_with_Stage_IA_and_Grade_2_Endometrial_Carcinoma_Undergoing_Fertility_Sparing_Treatment_A_Systematic_Review">Reproductive and Oncologic Outcomes in Young Women with Stage IA and Grade 2 Endometrial Carcinoma Undergoing Fertility-Sparing Treatment: A Systematic Review</a></div><div class="wp-workCard_item"><span>Biomolecules</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Endometrial cancer (EC) is the most common gynecological malignancy in both Europe an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Endometrial cancer (EC) is the most common gynecological malignancy in both Europe and the USA. Approximately 3-5% of cases occur in women of reproductive age. Fertility-sparing treatment (FST) options are available, but very limited evidence regarding grade 2 (G2) ECs exists in the current literature. This systematic review aimed to comprehensively evaluate reproductive and oncologic outcomes among young women diagnosed with stage IA or G2EC disease who underwent FST.<br /><br />Methods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies that reported the oncologic and reproductive outcomes of patients with stage IA and G2EC tumors who underwent FST were considered eligible for inclusion in this systematic review (CRD42023484892). Studies describing only the FST for endometrial hyperplasia or G1 EC were excluded.<br /><br />Results: Twenty-two papers that met the abovementioned inclusion criteria were included in the present systematic review. Preliminary analysis suggested encouraging oncologic and reproductive outcomes after FST.<br /><br />Conclusions: The FST approach may represent a feasible and safe option for women of childbearing age diagnosed with G2EC. Despite these promising findings, cautious interpretation is warranted due to inherent limitations, including heterogeneity in study designs and potential biases. Further research with standardized methodologies and larger sample sizes is imperative for obtaining more robust conclusions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a0a2028f3bd00ab4e0d7acf2e11c9bb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113041225,"asset_id":117089781,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113041225/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117089781"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117089781"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117089781; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117089781]").text(description); $(".js-view-count[data-work-id=117089781]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117089781; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117089781']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117089781, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a0a2028f3bd00ab4e0d7acf2e11c9bb" } } $('.js-work-strip[data-work-id=117089781]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117089781,"title":"Reproductive and Oncologic Outcomes in Young Women with Stage IA and Grade 2 Endometrial Carcinoma Undergoing Fertility-Sparing Treatment: A Systematic Review","translated_title":"","metadata":{"doi":"10.3390/biom14030306","abstract":"Background: Endometrial cancer (EC) is the most common gynecological malignancy in both Europe and the USA. Approximately 3-5% of cases occur in women of reproductive age. Fertility-sparing treatment (FST) options are available, but very limited evidence regarding grade 2 (G2) ECs exists in the current literature. This systematic review aimed to comprehensively evaluate reproductive and oncologic outcomes among young women diagnosed with stage IA or G2EC disease who underwent FST.\n\nMethods: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science. Only original studies that reported the oncologic and reproductive outcomes of patients with stage IA and G2EC tumors who underwent FST were considered eligible for inclusion in this systematic review (CRD42023484892). 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endometriosis: A review of systematic reviews" class="work-thumbnail" src="https://attachments.academia-assets.com/80721887/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/71334250/The_effectiveness_of_the_ultralong_GnRH_agonist_protocol_in_improving_IVF_outcomes_in_patients_with_endometriosis_A_review_of_systematic_reviews">The effectiveness of the ultralong GnRH agonist protocol in improving IVF outcomes in patients with endometriosis: A review of systematic reviews</a></div><div class="wp-workCard_item"><span>Proceedings of the Royal College of Obstetricians and Gynaecologists and Blair Bell Research Society Annual Academic Meeting</span><span>, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a 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Should we Update the Current Classification?" class="work-thumbnail" src="https://attachments.academia-assets.com/61147810/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/40862237/Dysmorphic_Uterus_Should_we_Update_the_Current_Classification">Dysmorphic Uterus. Should we Update the Current Classification?</a></div><div class="wp-workCard_item"><span>Journal of Minimally Invasive Gynecology</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Video Objective: To describe three different subtypes of dysmorphic uteri identified using 3D ult...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Video Objective: To describe three different subtypes of dysmorphic uteri identified using 3D ultrasound and hysteroscopy.<br />Setting: Endoscopy unit of an assisted fertility center.<br />Interventions: 3D transvaginal ultrasound and diagnostic hysteroscopy.<br />Conclusion: We identified three different subtypes of dysmorphic uterus. 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The T-shaped uterus, with thick lateral walls with normal uterine fundus and interostial distance; the Y-shaped uterus, with thick lateral walls, fundal septum or subseptum and reduced interostial distance; the I-shaped uterus, with very thick lateral walls (even above the isthmus) and severe reduction of the interostial distance.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"Journal of Minimally Invasive Gynecology"},"translated_abstract":"Video Objective: To describe three different subtypes of dysmorphic uteri identified using 3D ultrasound and hysteroscopy.\nSetting: Endoscopy unit of an assisted fertility center.\nInterventions: 3D transvaginal ultrasound and diagnostic hysteroscopy.\nConclusion: We identified three different subtypes of dysmorphic uterus. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="33641984"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/33641984/Routine_application_of_Jackson_Pratt_chest_drenage_after_diaphragmatic_surgery_for_advanced_ovarian_cancer_a_single_centre_experience"><img alt="Research paper thumbnail of Routine application of Jackson Pratt chest drenage after diaphragmatic surgery for advanced ovarian cancer: a single centre experience" class="work-thumbnail" src="https://attachments.academia-assets.com/53653763/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/33641984/Routine_application_of_Jackson_Pratt_chest_drenage_after_diaphragmatic_surgery_for_advanced_ovarian_cancer_a_single_centre_experience">Routine application of Jackson Pratt chest drenage after diaphragmatic surgery for advanced ovarian cancer: a single centre experience</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/DiegoRossetti">Diego Rossetti</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unico.academia.edu/GaetanoValenti">Gaetano Valenti</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://unico.academia.edu/SalvatoreGiovanniVitale">Salvatore Giovanni Vitale</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: Previous studies reported an high rates of postoperative pulmonary complications in p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: Previous studies reported an high rates of postoperative pulmonary complications in patients undergoing extensive cytoreductive surgery, including diafragmatic resection, for advanced epithelial ovarian cancer (EOC).<br />Methods: This study measured the incidence of postoperative pulmonary complications in a cohort of 21 patients undergoing routine application of Jackson Pratt (JP) drainage as chest tube after diafragmatic resection.<br />Results: The incidence of postoperative pulmonary complications like pleural effusion, pneumothorax and subdiaphragmatic abscess in our group of patients were respectively 33%, 0% and 5%.<br />Conclusions: This study demonstrated a low rate of postoperative pulmonary complications with the routinely application of JP as chest tube with no additional discomfort for patients. Randomized controlled trials are required to test the role of routinely use of chest tube in preventing postoperative pulmonary complications in patients undergoing upper abdominal surgery.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1dfbf634000b380ae5410916623c0237" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53653763,"asset_id":33641984,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53653763/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="33641984"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="33641984"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33641984; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33641984]").text(description); $(".js-view-count[data-work-id=33641984]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33641984; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='33641984']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 33641984, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1dfbf634000b380ae5410916623c0237" } } $('.js-work-strip[data-work-id=33641984]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":33641984,"title":"Routine application of Jackson Pratt chest drenage after diaphragmatic surgery for advanced ovarian cancer: a single centre experience","translated_title":"","metadata":{"abstract":"Objectives: Previous studies reported an high rates of postoperative pulmonary complications in patients undergoing extensive cytoreductive surgery, including diafragmatic resection, for advanced epithelial ovarian cancer (EOC).\nMethods: This study measured the incidence of postoperative pulmonary complications in a cohort of 21 patients undergoing routine application of Jackson Pratt (JP) drainage as chest tube after diafragmatic resection.\nResults: The incidence of postoperative pulmonary complications like pleural effusion, pneumothorax and subdiaphragmatic abscess in our group of patients were respectively 33%, 0% and 5%.\nConclusions: This study demonstrated a low rate of postoperative pulmonary complications with the routinely application of JP as chest tube with no additional discomfort for patients. Randomized controlled trials are required to test the role of routinely use of chest tube in preventing postoperative pulmonary complications in patients undergoing upper abdominal surgery."},"translated_abstract":"Objectives: Previous studies reported an high rates of postoperative pulmonary complications in patients undergoing extensive cytoreductive surgery, including diafragmatic resection, for advanced epithelial ovarian cancer (EOC).\nMethods: This study measured the incidence of postoperative pulmonary complications in a cohort of 21 patients undergoing routine application of Jackson Pratt (JP) drainage as chest tube after diafragmatic resection.\nResults: The incidence of postoperative pulmonary complications like pleural effusion, pneumothorax and subdiaphragmatic abscess in our group of patients were respectively 33%, 0% and 5%.\nConclusions: This study demonstrated a low rate of postoperative pulmonary complications with the routinely application of JP as chest tube with no additional discomfort for patients. Randomized controlled trials are required to test the role of routinely use of chest tube in preventing postoperative pulmonary complications in patients undergoing upper abdominal surgery.","internal_url":"https://www.academia.edu/33641984/Routine_application_of_Jackson_Pratt_chest_drenage_after_diaphragmatic_surgery_for_advanced_ovarian_cancer_a_single_centre_experience","translated_internal_url":"","created_at":"2017-06-25T03:55:49.615-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12242463,"coauthors_can_edit":true,"document_type":"conference_presentation","co_author_tags":[{"id":29501212,"work_id":33641984,"tagging_user_id":12242463,"tagged_user_id":60325051,"co_author_invite_id":null,"email":"d***i@gmail.com","display_order":1,"name":"Diego Rossetti","title":"Routine application of Jackson Pratt chest drenage after diaphragmatic surgery for advanced ovarian cancer: a single centre 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diaphragmatic surgery for advanced ovarian cancer: a single centre experience"},{"id":29501216,"work_id":33641984,"tagging_user_id":12242463,"tagged_user_id":65607495,"co_author_invite_id":null,"email":"s***e@gmail.com","display_order":5,"name":"Giuseppe Sarpietro","title":"Routine application of Jackson Pratt chest drenage after diaphragmatic surgery for advanced ovarian cancer: a single centre experience"},{"id":29501217,"work_id":33641984,"tagging_user_id":12242463,"tagged_user_id":57539824,"co_author_invite_id":null,"email":"a***p@live.it","display_order":6,"name":"Agnese Rapisarda","title":"Routine application of Jackson Pratt chest drenage after diaphragmatic surgery for advanced ovarian cancer: a single centre experience"},{"id":29501218,"work_id":33641984,"tagging_user_id":12242463,"tagged_user_id":61197235,"co_author_invite_id":null,"email":"f***a@libero.it","affiliation":"University of Catania","display_order":7,"name":"Fabrizio Sapia","title":"Routine application of Jackson 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hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/33616888/Radical_omentectomy_including_the_vascular_perigastric_arcade_in_stage_FIGO_III_C_serous_ovarian_tumors"><img alt="Research paper thumbnail of Radical omentectomy including the vascular perigastric arcade in stage FIGO III C serous ovarian tumors" class="work-thumbnail" src="https://attachments.academia-assets.com/53633909/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/33616888/Radical_omentectomy_including_the_vascular_perigastric_arcade_in_stage_FIGO_III_C_serous_ovarian_tumors">Radical omentectomy including the vascular perigastric arcade in stage FIGO III C serous ovarian tumors</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/DiegoRossetti">Diego Rossetti</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unico.academia.edu/GaetanoValenti">Gaetano Valenti</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://unico.academia.edu/SalvatoreGiovanniVitale">Salvatore Giovanni Vitale</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: The aim of this study was to document the presence of severe gastroplegia after radica...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: The aim of this study was to document the presence of severe gastroplegia after radical omentectomy including the perigastric area and lesser omentum in patients with FIGO stage III C serous epithelial ovarian tumors (EOT).<br />Methods: Patients undergoing radical omentectomy in the setting of surgery for FIGO stage IIIC EOT between Jannuary 2014 and Jannuary 2017 were included. Patients with macroscopic involvement of the perigastric area were excluded. The perigastric area was evaluated by an expert pathologist. Nasogastric tube was held for 48 hours. After that it was observed the recovery of gastric function.<br />Results: Fifteen patients were included. All the patients underwent primary debulking surgery. Microscopic involvement of the perigastric omentum area was found in 37% of the cases. Five patients needed to put back the nasogastric tube for severe gastric sintoms.<br />Summary: In this study, evidence is given that radical omentectomy including the perigastric area and lesser omentum is a necessary component of complete cytoreductive surgery in FIGO stage IIIC EOT, whatever great number of severe gastroplegia is reported.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fda3caf4ac4348a33f44482fb4aeaf3c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53633909,"asset_id":33616888,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53633909/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="33616888"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="33616888"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33616888; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33616888]").text(description); $(".js-view-count[data-work-id=33616888]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33616888; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='33616888']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 33616888, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fda3caf4ac4348a33f44482fb4aeaf3c" } } $('.js-work-strip[data-work-id=33616888]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":33616888,"title":"Radical omentectomy including the vascular perigastric arcade in stage FIGO III C serous ovarian tumors","translated_title":"","metadata":{"abstract":"Objective: The aim of this study was to document the presence of severe gastroplegia after radical omentectomy including the perigastric area and lesser omentum in patients with FIGO stage III C serous epithelial ovarian tumors (EOT).\nMethods: Patients undergoing radical omentectomy in the setting of surgery for FIGO stage IIIC EOT between Jannuary 2014 and Jannuary 2017 were included. Patients with macroscopic involvement of the perigastric area were excluded. The perigastric area was evaluated by an expert pathologist. Nasogastric tube was held for 48 hours. After that it was observed the recovery of gastric function.\nResults: Fifteen patients were included. All the patients underwent primary debulking surgery. Microscopic involvement of the perigastric omentum area was found in 37% of the cases. Five patients needed to put back the nasogastric tube for severe gastric sintoms.\nSummary: In this study, evidence is given that radical omentectomy including the perigastric area and lesser omentum is a necessary component of complete cytoreductive surgery in FIGO stage IIIC EOT, whatever great number of severe gastroplegia is reported."},"translated_abstract":"Objective: The aim of this study was to document the presence of severe gastroplegia after radical omentectomy including the perigastric area and lesser omentum in patients with FIGO stage III C serous epithelial ovarian tumors (EOT).\nMethods: Patients undergoing radical omentectomy in the setting of surgery for FIGO stage IIIC EOT between Jannuary 2014 and Jannuary 2017 were included. Patients with macroscopic involvement of the perigastric area were excluded. The perigastric area was evaluated by an expert pathologist. Nasogastric tube was held for 48 hours. 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class="js-work-strip profile--work_container" data-work-id="32186639"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/32186639/Does_exogenous_progesterone_modify_first_trimester_myocardial_performance_index_TEI_in_euploid_fetuses"><img alt="Research paper thumbnail of Does exogenous progesterone modify first trimester myocardial performance index (TEI) in euploid fetuses?" class="work-thumbnail" src="https://attachments.academia-assets.com/52420266/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/32186639/Does_exogenous_progesterone_modify_first_trimester_myocardial_performance_index_TEI_in_euploid_fetuses">Does exogenous progesterone modify first trimester myocardial performance index (TEI) in euploid fetuses?</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unico.academia.edu/SalvatoreGiovanniVitale">Salvatore Giovanni Vitale</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ClaudioGiorlandino">Claudio Giorlandino</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract in: 26th World Congress on Ultrasound in Obstetrics and Gynecology 2016, Marriott Park H...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract in: 26th World Congress on Ultrasound in Obstetrics and Gynecology 2016, Marriott Park Hotel, Roma 25/28 settembre 2016.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2e1e03e5a874c1214232f4bdc080e2ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52420266,"asset_id":32186639,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52420266/download_file?st=MTczMjc1NTE0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="32186639"><a class="js-profile-work-strip-edit-button" 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and <a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Poster in: European Board and College of Obstetrics and Gynaecology (EBCOG) 2016, Centro Congress...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Poster in: European Board and College of Obstetrics and Gynaecology (EBCOG) 2016, Centro Congressi Lingotto, Torino (TO) 19/21 maggio 2016.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ac98d5371317ae3f065d22ed7276db8c" class="wp-workCard--action" rel="nofollow" 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href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FerdinandoGulino">Ferdinando Gulino</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://unico.academia.edu/GaetanoValenti">Gaetano Valenti</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract in: 17th World Congress of Gynecological Endocrinology, Firenze fiera, Firenze (FI) 1/5 ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract in: 17th World Congress of Gynecological Endocrinology, Firenze fiera, Firenze (FI) 1/5 marzo 2016.</span></div><div class="wp-workCard_item 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href="https://www.academia.edu/32186577/Are_first_trimester_cardiac_fetal_dynamic_parameters_related_to_nuchal_translucency_thickness"><img alt="Research paper thumbnail of Are first trimester cardiac fetal dynamic parameters related to nuchal translucency thickness?" class="work-thumbnail" src="https://attachments.academia-assets.com/52420194/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/32186577/Are_first_trimester_cardiac_fetal_dynamic_parameters_related_to_nuchal_translucency_thickness">Are first trimester cardiac fetal dynamic parameters related to nuchal translucency thickness?</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unipa.academia.edu/AntonioSimoneLagan%C3%A0">Antonio Simone Laganà</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unico.academia.edu/SalvatoreGiovanniVitale">Salvatore Giovanni Vitale</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ClaudioGiorlandino">Claudio Giorlandino</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract in: 26th World Congress on Ultrasound in Obstetrics and Gynecology 2016, Marriott Park H...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract in: 26th World Congress on Ultrasound in Obstetrics and Gynecology 2016, Marriott Park Hotel, Roma 25/28 settembre 2016.</span></div><div 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="13904354" id="books"><div class="js-work-strip profile--work_container" data-work-id="116698864"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116698864/Aromatase_inhibitors_in_male_infertility_Letrozole_place_in_therapy"><img alt="Research paper thumbnail of Aromatase inhibitors in male infertility. Letrozole - place in therapy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116698864/Aromatase_inhibitors_in_male_infertility_Letrozole_place_in_therapy">Aromatase inhibitors in male infertility. Letrozole - place in therapy</a></div><div class="wp-workCard_item"><span>Content Ed Net</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There is no reliable treatment for men with idiopathic infertility, but the relationship between ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There is no reliable treatment for men with idiopathic infertility, but the relationship between severe sperm production and the ratio of estrogen to testosterone levels has been shown. Aromatase is an enzyme that plays an important role in converting testosterone to estradiol and androstenedione to estrogen. And Aromatase inhibitors can increase testosterone and androgen production without increasing the amount of estrogen in circulation.<br />One of the highlights of this book is an exploration of Letrozole, a medication originally developed for treating breast cancer, but now showing promising results as an innovative treatment for male infertility. We explored Letrozole’s mode of action and the clinical data that supports its administration, giving readers a thorough grasp of how it can revolutionize the field of treating male infertility.<br />This book aims to apprise the readers about the various aspects of male infertility, approach to management of the condition and role of Letrozole in male infertility treatment, as well as clinical evidence-based discussions on the results of trials and research from across the globe. 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Aromatase is an enzyme that plays an important role in converting testosterone to estradiol and androstenedione to estrogen. And Aromatase inhibitors can increase testosterone and androgen production without increasing the amount of estrogen in circulation.\nOne of the highlights of this book is an exploration of Letrozole, a medication originally developed for treating breast cancer, but now showing promising results as an innovative treatment for male infertility. We explored Letrozole’s mode of action and the clinical data that supports its administration, giving readers a thorough grasp of how it can revolutionize the field of treating male infertility.\nThis book aims to apprise the readers about the various aspects of male infertility, approach to management of the condition and role of Letrozole in male infertility treatment, as well as clinical evidence-based discussions on the results of trials and research from across the globe. 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Letrozole - place in therapy"}],"downloadable_attachments":[],"slug":"Aromatase_inhibitors_in_male_infertility_Letrozole_place_in_therapy","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12242463,"first_name":"Antonio Simone","middle_initials":null,"last_name":"Laganà","page_name":"AntonioSimoneLaganà","domain_name":"unipa","created_at":"2014-05-21T04:45:59.493-07:00","display_name":"Antonio Simone Laganà","url":"https://unipa.academia.edu/AntonioSimoneLagan%C3%A0"},"attachments":[],"research_interests":[{"id":25630,"name":"Endocrinology \u0026 Metabolism","url":"https://www.academia.edu/Documents/in/Endocrinology_and_Metabolism"},{"id":178928,"name":"Male Infertility","url":"https://www.academia.edu/Documents/in/Male_Infertility"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94522618"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94522618/Supplementation_with_D_chiro_inositol_in_women"><img alt="Research paper thumbnail of Supplementation with D-chiro-inositol in women" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94522618/Supplementation_with_D_chiro_inositol_in_women">Supplementation with D-chiro-inositol in women</a></div><div class="wp-workCard_item"><span>A Clinical Guide to Inositols</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The world of natural compounds has been investigated with the aim of discovering possible medical...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The world of natural compounds has been investigated with the aim of discovering possible medical applications ever since the origin of medicine. Recently, the field of gynecology has developed a growing interest regarding inositols. Inositols are cyclic polyols with a key role in many metabolic pathways. Their stability throughout the evolution of life can mark these molecules as prebiotic, due to their biochemical importance. These molecules can be classified into nine stereoisomeric compounds; among them, myo-inositol (MI) is the most important and frequent form found in nature. Inositols were first discovered in 1850 by Johanes Joseph Scherer and extracted from muscle cells, the name of which still persist in the compound (myo: muscle in greek). In humans, inositols are derived from the diet in the primary form of MI. Subsequently, MI can be unidirectionally converted into different forms such as D-chiro-inositol (DCI), thanks to insulin action, and with the action of a specific nicotinamide adenine dinucleotide (NAD)-NADH-dependent epimerase. The primary focus of this chapter is to examine and discuss the biochemical properties of DCI and its clinical implication. In particular, it will provide the details of possible clinical applications of DCI supplementation in women, considering the principal biochemical effects.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94522618"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94522618"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94522618; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94522618]").text(description); $(".js-view-count[data-work-id=94522618]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94522618; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94522618']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94522618, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94522618]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94522618,"title":"Supplementation with D-chiro-inositol in women","translated_title":"","metadata":{"doi":"10.1016/B978-0-323-91673-8.00004-2","abstract":"The world of natural compounds has been investigated with the aim of discovering possible medical applications ever since the origin of medicine. 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These molecules can be classified into nine stereoisomeric compounds; among them, myo-inositol (MI) is the most important and frequent form found in nature. Inositols were first discovered in 1850 by Johanes Joseph Scherer and extracted from muscle cells, the name of which still persist in the compound (myo: muscle in greek). In humans, inositols are derived from the diet in the primary form of MI. Subsequently, MI can be unidirectionally converted into different forms such as D-chiro-inositol (DCI), thanks to insulin action, and with the action of a specific nicotinamide adenine dinucleotide (NAD)-NADH-dependent epimerase. The primary focus of this chapter is to examine and discuss the biochemical properties of DCI and its clinical implication. 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