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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Endothelin-1</h1><div class="u-tcGrayDark">9 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Endothelin-1</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Endothelin-1">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Endothelin-1/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Endothelin-1/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Endothelin-1/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Endothelin-1">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5627577" data-work_id="5627577" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5627577/Endothelin1_stimulates_insulin_secretion_by_direct_action_on_the_islets_of_Langerhans_in_mice">Endothelin1 stimulates insulin secretion by direct action on the islets of Langerhans in mice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Endothelin-1 (ET-1), a potent endothelium-derived vasoconstrictor peptide, is secreted in response to insulin. Elevated circulating ET-1 levels have been found in patients with diabetes mellitus and vascular dysfunction. The question... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5627577" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Endothelin-1 (ET-1), a potent endothelium-derived vasoconstrictor peptide, is secreted in response to insulin. Elevated circulating ET-1 levels have been found in patients with diabetes mellitus and vascular dysfunction. The question arises whether ET-1 acts as a direct modulator of insulin secretion. To test this, we studied the effects of ET-1 on isolated mouse islets of Langerhans. ET-1 (1 nmol/l-1 Μmol/l) dose-dependently stimulated insulin secretion from islets incubated in the presence of 16.7 mmol/l glucose (p<0.05). The effect of ET-1 is glucose-dependent since no potentiation was found at 3.3 mmol/l glucose. Furthermore, ET-1 induced a large, transient increase in glucose-stimulated insulin secretion during islet perifusion in the presence (p<0.001), but not in the absence, of extracellular Ca2+. The rate of 45Ca2+-efflux from 45Ca2+-prelabelled islets was transiently stimulated by ET-1 during perifusion at 16.7 mmol/l glucose in the presence of extracellular Ca2+ (p<0.001). A short-lived increase in 45Ca2+-efflux was also observed in the absence of extracellular Ca2+ (p<0.05). It is suggested that the effects of ET-1 on insulin secretion are critically dependent on influx via Ca2+-channels. In addition, ET-1 transiently enhanced 86Rb+-efflux from 86Rb+-prelabelled islets both in the presence (p<0.001) and in the absence (p<0.001) of extracellular Ca2+ suggesting that ET-1 does not elicit insulin secretion by inhibition of the potassium permeability. Our study provides evidence that ET-1 stimulates insulin secretion via a direct effect on the islets of Langerhans.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5627577" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1512cde5acb70f2f5d50e02989a2c28c" rel="nofollow" data-download="{"attachment_id":49208635,"asset_id":5627577,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49208635/download_file?st=MTczMjczMTIwNSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8074246" href="https://rm.academia.edu/kjeldhermansen">kjeld hermansen</a><script data-card-contents-for-user="8074246" type="text/json">{"id":8074246,"first_name":"kjeld","last_name":"hermansen","domain_name":"rm","page_name":"kjeldhermansen","display_name":"kjeld hermansen","profile_url":"https://rm.academia.edu/kjeldhermansen?f_ri=539690","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_5627577 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5627577"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5627577, container: ".js-paper-rank-work_5627577", }); 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Elevated circulating ET-1 levels have been found in patients with diabetes mellitus and vascular dysfunction. The question arises whether ET-1 acts as a direct modulator of insulin secretion. To test this, we studied the effects of ET-1 on isolated mouse islets of Langerhans. ET-1 (1 nmol/l-1 Μmol/l) dose-dependently stimulated insulin secretion from islets incubated in the presence of 16.7 mmol/l glucose (p\u003c0.05). The effect of ET-1 is glucose-dependent since no potentiation was found at 3.3 mmol/l glucose. Furthermore, ET-1 induced a large, transient increase in glucose-stimulated insulin secretion during islet perifusion in the presence (p\u003c0.001), but not in the absence, of extracellular Ca2+. The rate of 45Ca2+-efflux from 45Ca2+-prelabelled islets was transiently stimulated by ET-1 during perifusion at 16.7 mmol/l glucose in the presence of extracellular Ca2+ (p\u003c0.001). A short-lived increase in 45Ca2+-efflux was also observed in the absence of extracellular Ca2+ (p\u003c0.05). It is suggested that the effects of ET-1 on insulin secretion are critically dependent on influx via Ca2+-channels. In addition, ET-1 transiently enhanced 86Rb+-efflux from 86Rb+-prelabelled islets both in the presence (p\u003c0.001) and in the absence (p\u003c0.001) of extracellular Ca2+ suggesting that ET-1 does not elicit insulin secretion by inhibition of the potassium permeability. Our study provides evidence that ET-1 stimulates insulin secretion via a direct effect on the islets of Langerhans.","downloadable_attachments":[{"id":49208635,"asset_id":5627577,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8074246,"first_name":"kjeld","last_name":"hermansen","domain_name":"rm","page_name":"kjeldhermansen","display_name":"kjeld hermansen","profile_url":"https://rm.academia.edu/kjeldhermansen?f_ri=539690","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=539690","nofollow":false},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=539690","nofollow":false},{"id":71289,"name":"Glucose","url":"https://www.academia.edu/Documents/in/Glucose?f_ri=539690","nofollow":false},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin?f_ri=539690","nofollow":false},{"id":71426,"name":"Insulin 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class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13043227/Endothelial_function_and_dysfunction_Part_I_Methodological_issues_for_assessment_in_the_different_vascular_beds_a_statement_by_the_Working_Group_on_Endothelin_and_Endothelial_Factors_of_the_European_Society_of_Hypertension">Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">An enormous number of studies in the last two decades have been devoted to investigating the role of the endothelium in cardiovascular diseases. Nonetheless, the optimal methodology for investigating the multifaceted aspects of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13043227" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">An enormous number of studies in the last two decades have been devoted to investigating the role of the endothelium in cardiovascular diseases. 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class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28219244/Endothelin_1_is_a_useful_biomarker_for_early_detection_of_bronchiolitis_obliterans_in_lung_transplant_recipients">Endothelin-1 is a useful biomarker for early detection of bronchiolitis obliterans in lung transplant recipients</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28219244" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ca300f69209b556827f4d7d9e5fd3062" rel="nofollow" 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type="text/json">{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="182337" href="https://www.academia.edu/Documents/in/Acute_Lung_Injury">Acute Lung Injury</a>, <script data-card-contents-for-ri="182337" type="text/json">{"id":182337,"name":"Acute Lung Injury","url":"https://www.academia.edu/Documents/in/Acute_Lung_Injury?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=539690","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18599962]'), work: 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22232943/Use_of_Diffusion_Tensor_Imaging_to_Predict_Myocardial_Viability_After_Warm_Global_Ischemia_Possible_Avenue_for_Use_of_Non_beating_Donor_Hearts">Use of Diffusion Tensor Imaging to Predict Myocardial Viability After Warm Global Ischemia: Possible Avenue for Use of Non-beating Donor Hearts</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22232943" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li 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href="https://www.academia.edu/Documents/in/Calcium">Calcium</a>, <script data-card-contents-for-ri="9534" type="text/json">{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="48057" href="https://www.academia.edu/Documents/in/DNA">DNA</a><script data-card-contents-for-ri="48057" type="text/json">{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA?f_ri=539690","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: 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structure determination of endothelin-1 in methanol/water by NMR and molecular modelling methods</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24989808" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="93a39928d8f6c6da7f81da67de49274d" rel="nofollow" data-download="{"attachment_id":45316781,"asset_id":24989808,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2215" href="https://www.academia.edu/Documents/in/Water">Water</a>, <script data-card-contents-for-ri="2215" type="text/json">{"id":2215,"name":"Water","url":"https://www.academia.edu/Documents/in/Water?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10896" href="https://www.academia.edu/Documents/in/Peptide_Science">Peptide Science</a>, <script data-card-contents-for-ri="10896" type="text/json">{"id":10896,"name":"Peptide Science","url":"https://www.academia.edu/Documents/in/Peptide_Science?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="21732" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy">Magnetic Resonance Spectroscopy</a>, <script data-card-contents-for-ri="21732" type="text/json">{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="69542" href="https://www.academia.edu/Documents/in/Computer_Simulation">Computer Simulation</a><script data-card-contents-for-ri="69542" type="text/json">{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation?f_ri=539690","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24989808]'), work: {"id":24989808,"title":"Solution structure determination of endothelin-1 in methanol/water by NMR and molecular modelling 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Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=539690"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20107214" data-work_id="20107214" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20107214/17_hydroxyprogesterone_blunts_the_hypertensive_response_associated_with_reductions_in_uterine_perfusion_pressure_in_pregnant_rats">17-hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant rats</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm 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necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha?f_ri=539690"},{"id":539690,"name":"Endothelin-1","url":"https://www.academia.edu/Documents/in/Endothelin-1?f_ri=539690"},{"id":872856,"name":"Utero","url":"https://www.academia.edu/Documents/in/Utero?f_ri=539690"},{"id":987472,"name":"Gestation","url":"https://www.academia.edu/Documents/in/Gestation?f_ri=539690"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_41830639" data-work_id="41830639" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/41830639/Role_BOZPAH_Tablets_Bosentan_Monohydrate_in_Pulmonary_Hypertension">Role BOZPAH Tablets (Bosentan Monohydrate) in Pulmonary Hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Bosentan is highly bound (>98%) to plasma proteins, mainly albumin. Bosentan does not penetrate into erythrocytes. A volume of distribution (Vss) of about 18 liters was determined after an intravenous dose of 250mg.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/41830639" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0032b9fed1e34cefa9bec59043538fe8" rel="nofollow" data-download="{"attachment_id":61968218,"asset_id":41830639,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/61968218/download_file?st=MTczMjczMTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12245559" href="https://ciitswl.academia.edu/NAWAZISHALISHAUKAT">NAWAZISH ALI SHAUKAT</a><script data-card-contents-for-user="12245559" type="text/json">{"id":12245559,"first_name":"NAWAZISH","last_name":"ALI SHAUKAT","domain_name":"ciitswl","page_name":"NAWAZISHALISHAUKAT","display_name":"NAWAZISH ALI SHAUKAT","profile_url":"https://ciitswl.academia.edu/NAWAZISHALISHAUKAT?f_ri=539690","photo":"https://0.academia-photos.com/12245559/3525016/4138756/s65_nawazish.ali_shaukat.jpg"}</script></span></span></li><li class="js-paper-rank-work_41830639 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="41830639"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 41830639, container: ".js-paper-rank-work_41830639", }); 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In a previous experiment involving 4-wk-old lambs with pulmonary hypertension... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19357885" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neonates and infants with congenital heart disease with increased pulmonary blood flow suffer morbidity from poor oxygenation and decreased lung compliance. In a previous experiment involving 4-wk-old lambs with pulmonary hypertension secondary to increased pulmonary blood flow following an in utero placement of an aortopulmonary vascular graft, we found a decrease in surfactant protein (SP)-A gene expression as well as a decrease in SP-A and SP-B protein contents. To determine the timing of these changes, the objective of the present study was to characterize the effect of increased pulmonary blood flow and pulmonary hypertension on SP-A, -B, and -C gene expressions and protein contents within the first week of life. Of eight fetal lambs that underwent the in utero placement of the shunt, there was no difference in the expression of SP-A, -B, and -C mRNA levels or SP-A and -B protein contents compared with age-matched controls. The results showed that, in this model of congenital heart disease with pulmonary hypertension and increased pulmonary blood flow, the effect of the shunt on SP gene expression and protein content was not apparent within the first week of life.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19357885" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="09ca09823546f1176022cb8430c9d614" rel="nofollow" data-download="{"attachment_id":42096231,"asset_id":19357885,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42096231/download_file?st=MTczMjczMTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39623382" href="https://userena.academia.edu/SoniaSalas">Sonia Salas</a><script data-card-contents-for-user="39623382" type="text/json">{"id":39623382,"first_name":"Sonia","last_name":"Salas","domain_name":"userena","page_name":"SoniaSalas","display_name":"Sonia Salas","profile_url":"https://userena.academia.edu/SoniaSalas?f_ri=539690","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_19357885 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19357885"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19357885, container: ".js-paper-rank-work_19357885", }); 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In a previous experiment involving 4-wk-old lambs with pulmonary hypertension secondary to increased pulmonary blood flow following an in utero placement of an aortopulmonary vascular graft, we found a decrease in surfactant protein (SP)-A gene expression as well as a decrease in SP-A and SP-B protein contents. To determine the timing of these changes, the objective of the present study was to characterize the effect of increased pulmonary blood flow and pulmonary hypertension on SP-A, -B, and -C gene expressions and protein contents within the first week of life. Of eight fetal lambs that underwent the in utero placement of the shunt, there was no difference in the expression of SP-A, -B, and -C mRNA levels or SP-A and -B protein contents compared with age-matched controls. The results showed that, in this model of congenital heart disease with pulmonary hypertension and increased pulmonary blood flow, the effect of the shunt on SP gene expression and protein content was not apparent within the first week of life.","downloadable_attachments":[{"id":42096231,"asset_id":19357885,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39623382,"first_name":"Sonia","last_name":"Salas","domain_name":"userena","page_name":"SoniaSalas","display_name":"Sonia Salas","profile_url":"https://userena.academia.edu/SoniaSalas?f_ri=539690","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=539690","nofollow":false},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=539690","nofollow":false},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=539690","nofollow":false},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=539690","nofollow":false},{"id":84913,"name":"Sheep","url":"https://www.academia.edu/Documents/in/Sheep?f_ri=539690"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=539690"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=539690"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=539690"},{"id":379301,"name":"SURFACTANT PROTEIN A","url":"https://www.academia.edu/Documents/in/SURFACTANT_PROTEIN_A?f_ri=539690"},{"id":539690,"name":"Endothelin-1","url":"https://www.academia.edu/Documents/in/Endothelin-1?f_ri=539690"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=539690"},{"id":735030,"name":"Congenital Heart Disease","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Disease?f_ri=539690"},{"id":1969879,"name":"Vascular Resistance","url":"https://www.academia.edu/Documents/in/Vascular_Resistance?f_ri=539690"},{"id":2226523,"name":"Pulmonary circulation","url":"https://www.academia.edu/Documents/in/Pulmonary_circulation?f_ri=539690"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17469535" data-work_id="17469535" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17469535/Protective_effects_of_endothelin_antagonists_in_chronic_renal_failure">Protective effects of endothelin antagonists in chronic renal failure</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17469535" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="87e4d4061c13b276fd3e5844cd13cdfc" rel="nofollow" data-download="{"attachment_id":39526807,"asset_id":17469535,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="375054" href="https://www.academia.edu/Documents/in/Rats">Rats</a><script data-card-contents-for-ri="375054" type="text/json">{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=539690","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17469535]'), work: {"id":17469535,"title":"Protective effects of endothelin antagonists in chronic renal 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href="https://www.academia.edu/17448761/Effect_of_lidocaine_on_endothelin_1_mediated_airway_smooth_muscle_contraction_in_the_rat_trachea">Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Endothelin-1 (ET-1) is a 21-amino acid peptide that induces airway smooth muscle (ASM) constriction by activating G-protein-coupled endothelin receptors A (ETA) and B (ETB), thereby increasing intracellular calcium ([Ca(2+)]i). Lidocaine... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17448761" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Endothelin-1 (ET-1) is a 21-amino acid peptide that induces airway smooth muscle (ASM) constriction by activating G-protein-coupled endothelin receptors A (ETA) and B (ETB), thereby increasing intracellular calcium ([Ca(2+)]i). Lidocaine can cause direct ASM relaxation by decreasing [Ca(2+)]i. This study investigated the direct relaxant effects of lidocaine on ET-1-induced contraction in rat tracheas. Mid-tracheal rings (2-3 mm diameter) were excised and attached to a force transducer suspended in Krebs-Henseliet solution. Carbachol concentration-response curves (10 nM and 100 microM) were generated to determine maximal contractility (C(max)). ET-1 (3 nM to 200 nM) responses to lidocaine (100 nM, 10 microM, and 1 mM) were measured in the presence and absence of extracellular calcium. Contractile responses to ET-1 are presented as percentage of Cmax (% Cmax). Data were analyzed using analysis of variance and unpaired t-tests with Welsh correction. No significant effect on ET-1-induce...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17448761" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5f46024e24f29aa1b29906b78957ec47" rel="nofollow" data-download="{"attachment_id":39514392,"asset_id":17448761,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39514392/download_file?st=MTczMjczMTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37190301" href="https://independent.academia.edu/SorinBrull">Sorin Brull</a><script data-card-contents-for-user="37190301" type="text/json">{"id":37190301,"first_name":"Sorin","last_name":"Brull","domain_name":"independent","page_name":"SorinBrull","display_name":"Sorin Brull","profile_url":"https://independent.academia.edu/SorinBrull?f_ri=539690","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17448761 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17448761"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17448761, container: ".js-paper-rank-work_17448761", }); 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Lidocaine can cause direct ASM relaxation by decreasing [Ca(2+)]i. This study investigated the direct relaxant effects of lidocaine on ET-1-induced contraction in rat tracheas. Mid-tracheal rings (2-3 mm diameter) were excised and attached to a force transducer suspended in Krebs-Henseliet solution. Carbachol concentration-response curves (10 nM and 100 microM) were generated to determine maximal contractility (C(max)). ET-1 (3 nM to 200 nM) responses to lidocaine (100 nM, 10 microM, and 1 mM) were measured in the presence and absence of extracellular calcium. Contractile responses to ET-1 are presented as percentage of Cmax (% Cmax). Data were analyzed using analysis of variance and unpaired t-tests with Welsh correction. No significant effect on ET-1-induce...","downloadable_attachments":[{"id":39514392,"asset_id":17448761,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37190301,"first_name":"Sorin","last_name":"Brull","domain_name":"independent","page_name":"SorinBrull","display_name":"Sorin Brull","profile_url":"https://independent.academia.edu/SorinBrull?f_ri=539690","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=539690","nofollow":false},{"id":65171,"name":"Smooth muscle","url":"https://www.academia.edu/Documents/in/Smooth_muscle?f_ri=539690","nofollow":false},{"id":99271,"name":"Calcium channels","url":"https://www.academia.edu/Documents/in/Calcium_channels?f_ri=539690","nofollow":false},{"id":140081,"name":"Calcium 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href="https://www.academia.edu/4520911/Conversion_From_Calcineurin_Inhibitors_to_Sirolimus_for_Chronic_Renal_Allograft_Dysfunction_A_Systematic_Review_of_the_Evidence">Conversion From Calcineurin Inhibitors to Sirolimus for Chronic Renal Allograft Dysfunction: A Systematic Review of the Evidence</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4520911" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b88f09b0a08c121b325b221b4d4a2d55" rel="nofollow" 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href="https://www.academia.edu/24506255/Circulating_Levels_of_Markers_of_Inflammation_and_Endothelial_Activation_are_Increased_in_Men_with_Chronic_Spinal_Cord_Injury">Circulating Levels of Markers of Inflammation and Endothelial Activation are Increased in Men with Chronic Spinal Cord Injury</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24506255" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="214aabf9c11a984022418226df560e58" rel="nofollow" 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A quantitative immunohistochemical study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Endothelin-1 (ET-1) is a vasoconstrictor peptide which is produced by endothelial cells. The subcellular distribution of ET-1 in human skin and the variation of immunostaining for ET-1 by light microscopy in skin biopsies of diabetic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_3343287" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Endothelin-1 (ET-1) is a vasoconstrictor peptide which is produced by endothelial cells. The subcellular distribution of ET-1 in human skin and the variation of immunostaining for ET-1 by light microscopy in skin biopsies of diabetic patients have been analysed using immunohistochemistry and image analysis quantification. Skin biopsies were collected from 17 patients with type 1 diabetes of different durations and with presence or absence of microangiopathy in the retina; skin biopsies of healthy subjects were utilized as controls. The distribution of ET-1 immunoreactivity (IR) at both light and electron microscopy was compared to that of von Willebrand factor (vWf), a general marker of total cutaneous microvessels. Immunohistochemistry revealed that in controls the distribution of immunostaining was similar for ET-1 and vWf, being localized to microvessels in all areas of the skin. However, at the electron microscopical level ET-1-IR was localized in the endothelial cytoplasm rather than in specific organelles, while vWf immunostaining was associated with Weibel-Palade bodies. ET-1-IR was observed in 4/8 (50 per cent) biopsies from healthy subjects; this increased to 81.8 per cent in biopsies of patients affected by diabetes for less than 10 years and decreased to 16.6 per cent in patients with diabetes for more than 10 years. Quantification of ET-1 staining showed a significant decrease of ET-1-IR in patients affected by diabetes for more than 10 years compared with those affected by diabetes for less than 10 years (P<0.05). Also, the percentage of biopsies showing positive ET-1 staining was lower in patients with retinopathy than in patients without retinopathy. On the contrary, vWf-IR was observed in all skin specimens and its quantification showed no differences between diabetic patients and controls. These changes are not related to variations in the number of blood vessels, and it is suggested that they reflect a possible functional alteration of the endothelial cells during diabetes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/3343287" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1c59bf569382a56f748168f7e34bea97" rel="nofollow" data-download="{"attachment_id":50324350,"asset_id":3343287,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50324350/download_file?st=MTczMjczMTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="2826514" href="https://independent.academia.edu/GPoccia">Gianfranco Poccia</a><script data-card-contents-for-user="2826514" type="text/json">{"id":2826514,"first_name":"Gianfranco","last_name":"Poccia","domain_name":"independent","page_name":"GPoccia","display_name":"Gianfranco Poccia","profile_url":"https://independent.academia.edu/GPoccia?f_ri=539690","photo":"https://0.academia-photos.com/2826514/924664/1157595/s65_gianfranco.poccia.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-3343287">+1</span><div class="hidden js-additional-users-3343287"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/GianfrancoProperzi">Gianfranco Properzi</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-3343287'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-3343287').html(); 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A quantitative immunohistochemical study","created_at":"2013-04-20T08:37:51.769-07:00","url":"https://www.academia.edu/3343287/Early_increase_precedes_a_depletion_of_endothelin_1_but_not_of_von_Willebrand_factor_in_cutaneous_microvessels_of_diabetic_patients_A_quantitative_immunohistochemical_study?f_ri=539690","dom_id":"work_3343287","summary":"Endothelin-1 (ET-1) is a vasoconstrictor peptide which is produced by endothelial cells. The subcellular distribution of ET-1 in human skin and the variation of immunostaining for ET-1 by light microscopy in skin biopsies of diabetic patients have been analysed using immunohistochemistry and image analysis quantification. Skin biopsies were collected from 17 patients with type 1 diabetes of different durations and with presence or absence of microangiopathy in the retina; skin biopsies of healthy subjects were utilized as controls. The distribution of ET-1 immunoreactivity (IR) at both light and electron microscopy was compared to that of von Willebrand factor (vWf), a general marker of total cutaneous microvessels. Immunohistochemistry revealed that in controls the distribution of immunostaining was similar for ET-1 and vWf, being localized to microvessels in all areas of the skin. However, at the electron microscopical level ET-1-IR was localized in the endothelial cytoplasm rather than in specific organelles, while vWf immunostaining was associated with Weibel-Palade bodies. ET-1-IR was observed in 4/8 (50 per cent) biopsies from healthy subjects; this increased to 81.8 per cent in biopsies of patients affected by diabetes for less than 10 years and decreased to 16.6 per cent in patients with diabetes for more than 10 years. Quantification of ET-1 staining showed a significant decrease of ET-1-IR in patients affected by diabetes for more than 10 years compared with those affected by diabetes for less than 10 years (P\u003c0.05). Also, the percentage of biopsies showing positive ET-1 staining was lower in patients with retinopathy than in patients without retinopathy. On the contrary, vWf-IR was observed in all skin specimens and its quantification showed no differences between diabetic patients and controls. These changes are not related to variations in the number of blood vessels, and it is suggested that they reflect a possible functional alteration of the endothelial cells during diabetes.","downloadable_attachments":[{"id":50324350,"asset_id":3343287,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":2826514,"first_name":"Gianfranco","last_name":"Poccia","domain_name":"independent","page_name":"GPoccia","display_name":"Gianfranco Poccia","profile_url":"https://independent.academia.edu/GPoccia?f_ri=539690","photo":"https://0.academia-photos.com/2826514/924664/1157595/s65_gianfranco.poccia.jpg"},{"id":59870047,"first_name":"Gianfranco","last_name":"Properzi","domain_name":"independent","page_name":"GianfrancoProperzi","display_name":"Gianfranco 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u-linkUnstyled" data-container=".work_19956447" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In the present study, we examined the pattern of Evan&amp;#39;s blue (EB) extravasation over time and we verified the effect of two inhibitors of aldose reductase (sorbinil and ARI 509) as well as aminoguanidine, which modulate nitric oxide (NO) production, on streptozotocin-induced capillary extravasation abnormalities in the upper bronchi, heart, kidney, duodenum, pancreas, skeletal muscle and skin. Albumin extravasation was measured using the EB technique (20 mg/kg). On the third day, a transient decrease in EB leakage was observed in the lung (-49%), heart (-29%) and skeletal muscle (-64%). These early changes in EB were transient, and values returned to normal there after. Later on, EB extravasation was significantly enhanced in the skin (+358, +680, +580, +525 and +365, respectively, at 2, 4, 5, 6 and 7 weeks of diabetes), the duodenum (+101, +160, +92, +124 and +76%), the upper bronchus (+70, +113, +70, +41 and +25%) and the pancreas (+43, +102, +46, +15 and +78%). In the kidney, the increase of EB extravasation was significant at 2 weeks (26%), and from 5 to 7 weeks (+12, +22, +36%). The chronic treatment of diabetic rats with aminoguanidine normalized capillary permeability in most tissues, suggesting that NO is involved in the development of endothelium dysfunction in this streptozotocin-induced diabetic model. Treatment with aldose reductase inhibitors selectively normalized EB extravasation in the kidney.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19956447" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bcb99a917034081e693c9a6eea5e2cc0" rel="nofollow" data-download="{"attachment_id":41999968,"asset_id":19956447,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41999968/download_file?st=MTczMjczMTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40824777" href="https://independent.academia.edu/BerndBalletshofer">Bernd Balletshofer</a><script data-card-contents-for-user="40824777" type="text/json">{"id":40824777,"first_name":"Bernd","last_name":"Balletshofer","domain_name":"independent","page_name":"BerndBalletshofer","display_name":"Bernd Balletshofer","profile_url":"https://independent.academia.edu/BerndBalletshofer?f_ri=539690","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_19956447 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19956447"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19956447, container: ".js-paper-rank-work_19956447", }); 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Albumin extravasation was measured using the EB technique (20 mg/kg). On the third day, a transient decrease in EB leakage was observed in the lung (-49%), heart (-29%) and skeletal muscle (-64%). These early changes in EB were transient, and values returned to normal there after. Later on, EB extravasation was significantly enhanced in the skin (+358, +680, +580, +525 and +365, respectively, at 2, 4, 5, 6 and 7 weeks of diabetes), the duodenum (+101, +160, +92, +124 and +76%), the upper bronchus (+70, +113, +70, +41 and +25%) and the pancreas (+43, +102, +46, +15 and +78%). In the kidney, the increase of EB extravasation was significant at 2 weeks (26%), and from 5 to 7 weeks (+12, +22, +36%). The chronic treatment of diabetic rats with aminoguanidine normalized capillary permeability in most tissues, suggesting that NO is involved in the development of endothelium dysfunction in this streptozotocin-induced diabetic model. Treatment with aldose reductase inhibitors selectively normalized EB extravasation in the kidney.","downloadable_attachments":[{"id":41999968,"asset_id":19956447,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40824777,"first_name":"Bernd","last_name":"Balletshofer","domain_name":"independent","page_name":"BerndBalletshofer","display_name":"Bernd Balletshofer","profile_url":"https://independent.academia.edu/BerndBalletshofer?f_ri=539690","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12981,"name":"Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Enzyme_Inhibitors?f_ri=539690","nofollow":false},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=539690","nofollow":false},{"id":138877,"name":"Vascular endothelium","url":"https://www.academia.edu/Documents/in/Vascular_endothelium?f_ri=539690","nofollow":false},{"id":244814,"name":"Clinical 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href="https://www.academia.edu/Documents/in/Disease_susceptibility">Disease susceptibility</a>, <script data-card-contents-for-ri="29974" type="text/json">{"id":29974,"name":"Disease susceptibility","url":"https://www.academia.edu/Documents/in/Disease_susceptibility?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37931" href="https://www.academia.edu/Documents/in/Transgenic_Mice">Transgenic Mice</a>, <script data-card-contents-for-ri="37931" type="text/json">{"id":37931,"name":"Transgenic Mice","url":"https://www.academia.edu/Documents/in/Transgenic_Mice?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="48183" href="https://www.academia.edu/Documents/in/Lipopolysaccharide">Lipopolysaccharide</a><script data-card-contents-for-ri="48183" 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/29124255/Endothelin_2_in_Ovarian_Follicle_Rupture">Endothelin-2 in Ovarian Follicle Rupture</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29124255" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3974df0d16108435810400c1ac5b12f8" rel="nofollow" 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expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=539690","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="65171" href="https://www.academia.edu/Documents/in/Smooth_muscle">Smooth muscle</a><script data-card-contents-for-ri="65171" type="text/json">{"id":65171,"name":"Smooth muscle","url":"https://www.academia.edu/Documents/in/Smooth_muscle?f_ri=539690","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=29124255]'), work: {"id":29124255,"title":"Endothelin-2 in Ovarian Follicle 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class="clearfix u-pv7x u-mb0x js-work-card work_28691634 coauthored" data-work_id="28691634" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28691634/The_Influences_of_Obesity_and_Glycemic_Control_on_Endothelial_Activation_in_Patients_with_Type_2_Diabetes">The Influences of Obesity and Glycemic Control on Endothelial Activation in Patients with Type 2 Diabetes</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28691634" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" 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data-has-card-for-user="53921969" href="https://independent.academia.edu/WBagg">W. Bagg</a><script data-card-contents-for-user="53921969" type="text/json">{"id":53921969,"first_name":"W.","last_name":"Bagg","domain_name":"independent","page_name":"WBagg","display_name":"W. 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