CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Dionysios Papachristou Md | University of Patras - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="B6eL0UefBqflcyOSfJUFwTcw0SMKdsZYQG8LMOxMOyWR-f6aOqHHubDTByOwM5hsdgHnoPLPnoHgKkHXbFSFMQ" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-3d36c19b4875b226bfed0fcba1dcea3f2fe61148383d97c0465c016b8c969290.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-79e78ce59bef0a338eb6540ec3d93b4a7952115b56c57f1760943128f4544d42.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-95367dc03b794f6737f30123738a886cf53b7a65cdef98a922a98591d60063e3.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-bfbac2a470372e2f3a6661a65fa7ff0a0fbf7aa32534d9a831d683d2a6f9e01b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-170d1319f0e354621e81ca17054bb147da2856ec0702fe440a99af314a6338c5.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="author" content="dionysios papachristou md" /> <meta name="description" content="Dionysios Papachristou Md, University of Patras: 27 Followers, 22 Following, 51 Research papers. Research interests: Validity Research, Generalized Linear…" /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = 'bbdb80613189ba697977787ab78246749f444764'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":14016,"monthly_visitors":"107 million","monthly_visitor_count":107440917,"monthly_visitor_count_in_millions":107,"user_count":283665332,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1740482156000); window.Aedu.timeDifference = new Date().getTime() - 1740482156000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link rel="preload" href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" as="style" onload="this.rel='stylesheet'"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-1eb081e01ca8bc0c1b1d866df79d9eb4dd2c484e4beecf76e79a7806c72fee08.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-0f3bf7f6f3517097948bf4ffb828d255bab326cd7f9daa1b0fac1bbd8d6b6df6.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-bb770f3e69f95986e63e7c7781a4a48d351e700cb7be914bb67d866ee608a254.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://upatras.academia.edu/DionysiosPapachristouMd" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-cc15444cb79edeb8ffc95efe7d12e4ad4e4df656440f173bd09913cdd0643e0d.js" defer="defer"></script><script>$viewedUser = Aedu.User.set_viewed( {"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd","photo":"https://0.academia-photos.com/32809036/9774300/10889516/s65_dionysios_papachristou.md.jpg_oh_98fc89a98b16832db4f393ab6548b695_oe_56211402___gda___1444069583_05878d599a4ef54d684eae6b1d1f1f72","has_photo":true,"department":{"id":1563759,"name":"Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies","url":"https://upatras.academia.edu/Departments/Anatomy_Histology_Embryology_Unit_of_Bone_and_Soft_Tissue_Studies/Documents","university":{"id":1405,"name":"University of Patras","url":"https://upatras.academia.edu/"}},"position":"Faculty Member","position_id":1,"is_analytics_public":false,"interests":[{"id":46694,"name":"Validity Research","url":"https://www.academia.edu/Documents/in/Validity_Research"},{"id":40172,"name":"Generalized Linear models","url":"https://www.academia.edu/Documents/in/Generalized_Linear_models"},{"id":32433,"name":"Logistic Regression","url":"https://www.academia.edu/Documents/in/Logistic_Regression"},{"id":19120,"name":"Regression Models","url":"https://www.academia.edu/Documents/in/Regression_Models"},{"id":8566,"name":"Clinical Epidemiology","url":"https://www.academia.edu/Documents/in/Clinical_Epidemiology"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://upatras.academia.edu/DionysiosPapachristouMd","location":"/DionysiosPapachristouMd","scheme":"https","host":"upatras.academia.edu","port":null,"pathname":"/DionysiosPapachristouMd","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-7ffacad4-0610-41af-8f46-56d05059d144"></div> <div id="ProfileCheckPaperUpdate-react-component-7ffacad4-0610-41af-8f46-56d05059d144"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Dionysios Papachristou Md" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/32809036/9774300/10889516/s200_dionysios_papachristou.md.jpg_oh_98fc89a98b16832db4f393ab6548b695_oe_56211402___gda___1444069583_05878d599a4ef54d684eae6b1d1f1f72" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Dionysios Papachristou Md</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://upatras.academia.edu/">University of Patras</a>, <a class="u-tcGrayDarker" href="https://upatras.academia.edu/Departments/Anatomy_Histology_Embryology_Unit_of_Bone_and_Soft_Tissue_Studies/Documents">Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Dionysios Papachristou" data-follow-user-id="32809036" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="32809036"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">27</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">22</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">7</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/DionysiosPapachristouMd/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://upatras.academia.edu/NikolaosBouropoulos"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://upatras.academia.edu/NikolaosBouropoulos">Nikolaos Bouropoulos</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Patras</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/PavolSzomolanyi"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/PavolSzomolanyi">Pavol Szomolanyi</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/FangsenCui"><img class="profile-avatar u-positionAbsolute" alt="Fangsen Cui" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/176768250/122976182/112320996/s200_fangsen.cui.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/FangsenCui">Fangsen Cui</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/AdetolaAdesida"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/AdetolaAdesida">Adetola Adesida</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/MKLotz"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/MKLotz">MK Lotz</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://scrippshealth.academia.edu/ShawnGrogan"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://scrippshealth.academia.edu/ShawnGrogan">Shawn Grogan</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Scripps Health</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://srmuniv.academia.edu/ShantanuPatil"><img class="profile-avatar u-positionAbsolute" alt="Shantanu S Patil" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/49683930/14099821/15106126/s200_shantanu.patil.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://srmuniv.academia.edu/ShantanuPatil">Shantanu S Patil</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">SRM UNIVERSITY</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/NickSkaer"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/NickSkaer">Nick Skaer</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://washington.academia.edu/AlbertGee"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://washington.academia.edu/AlbertGee">Albert Gee</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Washington</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/RussellHuffman"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/RussellHuffman">Russell Huffman</a></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32809036" href="https://www.academia.edu/Documents/in/Validity_Research"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://upatras.academia.edu/DionysiosPapachristouMd","location":"/DionysiosPapachristouMd","scheme":"https","host":"upatras.academia.edu","port":null,"pathname":"/DionysiosPapachristouMd","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Validity Research"]}" data-trace="false" data-dom-id="Pill-react-component-5ec864ad-c2eb-43de-b71d-83fdd1bc4440"></div> <div id="Pill-react-component-5ec864ad-c2eb-43de-b71d-83fdd1bc4440"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32809036" href="https://www.academia.edu/Documents/in/Generalized_Linear_models"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Generalized Linear models"]}" data-trace="false" data-dom-id="Pill-react-component-faddeffd-e815-41aa-9a59-7a83f2664711"></div> <div id="Pill-react-component-faddeffd-e815-41aa-9a59-7a83f2664711"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32809036" href="https://www.academia.edu/Documents/in/Logistic_Regression"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Logistic Regression"]}" data-trace="false" data-dom-id="Pill-react-component-981b6c20-2750-4aed-b230-097ab001a781"></div> <div id="Pill-react-component-981b6c20-2750-4aed-b230-097ab001a781"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32809036" href="https://www.academia.edu/Documents/in/Regression_Models"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Regression Models"]}" data-trace="false" data-dom-id="Pill-react-component-a2ccca1e-aaaf-4c6a-98e1-3cd13e77a104"></div> <div id="Pill-react-component-a2ccca1e-aaaf-4c6a-98e1-3cd13e77a104"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32809036" href="https://www.academia.edu/Documents/in/Clinical_Epidemiology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Clinical Epidemiology"]}" data-trace="false" data-dom-id="Pill-react-component-bd06d2d3-4d37-4c7e-a7b6-2119da33c6f4"></div> <div id="Pill-react-component-bd06d2d3-4d37-4c7e-a7b6-2119da33c6f4"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Dionysios Papachristou Md</h3></div><div class="js-work-strip profile--work_container" data-work-id="72782692"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782692/Collagen_orientation_probed_by_polarized_Raman_spectra_can_serve_as_differential_diagnosis_indicator_between_different_grades_of_meniscus_degeneration"><img alt="Research paper thumbnail of Collagen orientation probed by polarized Raman spectra can serve as differential diagnosis indicator between different grades of meniscus degeneration" class="work-thumbnail" src="https://attachments.academia-assets.com/81572940/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782692/Collagen_orientation_probed_by_polarized_Raman_spectra_can_serve_as_differential_diagnosis_indicator_between_different_grades_of_meniscus_degeneration">Collagen orientation probed by polarized Raman spectra can serve as differential diagnosis indicator between different grades of meniscus degeneration</a></div><div class="wp-workCard_item"><span>Scientific Reports</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of the present study was to analyze normal and degenerated menisci with Raman methodo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of the present study was to analyze normal and degenerated menisci with Raman methodology on thin sections of formalin fixed paraffin embedding tissues and to correlate the Raman findings with the grade of meniscus degeneration. Menisci (n = 27) were removed from human knee joints after total knee replacement or meniscectomy. Following routine histopathological analysis to determine the grade of meniscal lesions obtained from healthy and degenerated formaline fixed paraffin embedded (FFPE) meniscal sections, Raman polarization approach was applied to evaluate the orientation of collagen fibrils in different levels of the same 5 μm thick FFPE meniscal tissue sections, used for histopathological assessment. We collected Raman spectra in two different polarization geometries, v-HH and v-VV, and calculated the mean value of the v-HH/v-VV intensity ratio of two Raman bands, sensitive and non-sensitive to the molecular orientation. The collagen specific amide I band at 1665 cm...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0d41b54097ae57a68a3110d8430f56e5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572940,"asset_id":72782692,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572940/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782692"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782692"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782692; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782692]").text(description); $(".js-view-count[data-work-id=72782692]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782692; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782692']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0d41b54097ae57a68a3110d8430f56e5" } } $('.js-work-strip[data-work-id=72782692]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782692,"title":"Collagen orientation probed by polarized Raman spectra can serve as differential diagnosis indicator between different grades of meniscus degeneration","internal_url":"https://www.academia.edu/72782692/Collagen_orientation_probed_by_polarized_Raman_spectra_can_serve_as_differential_diagnosis_indicator_between_different_grades_of_meniscus_degeneration","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572940,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572940/thumbnails/1.jpg","file_name":"s41598-021-99569-2.pdf","download_url":"https://www.academia.edu/attachments/81572940/download_file","bulk_download_file_name":"Collagen_orientation_probed_by_polarized.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572940/s41598-021-99569-2-libre.pdf?1646226221=\u0026response-content-disposition=attachment%3B+filename%3DCollagen_orientation_probed_by_polarized.pdf\u0026Expires=1740429569\u0026Signature=CRfazlWt4BLCQd-h2mrY39jDxe7Ke~Eqh4DlJXAeBIfOsslmRh~BAVERVdZ8VqnOXaLyJlZG93Uik0AB8H1d6hFIzANTjsCukXR7dakSdF2Gdi6TeZv~-fBw4X3o7VmijHkV0UGPMQZvu6DiTpRfnJbX09Scj2cVZnWTXTsuroxMzkYvdOpRsMoJKgkC7LpkxaP98SY0VFjEYBvTzlzo7RlWfvLXbWo6wnnQKmoUIzKUFjHVHe7kEsGcJTpGtJyLP7BGTTS0StecNk1zvqprCdzuGX93l5KYbx-eyfU1nGrHY~YaFdcQtZr-nJ0DojbJxlwCSd5y6ghN1-qmNmUokg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":81572941,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572941/thumbnails/1.jpg","file_name":"s41598-021-99569-2.pdf","download_url":"https://www.academia.edu/attachments/81572941/download_file","bulk_download_file_name":"Collagen_orientation_probed_by_polarized.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572941/s41598-021-99569-2-libre.pdf?1646226221=\u0026response-content-disposition=attachment%3B+filename%3DCollagen_orientation_probed_by_polarized.pdf\u0026Expires=1740429569\u0026Signature=ZE18cJDEvxMzMoW1lixXE7b2SxCPnOMEK0B-NLyK9I00tnPV4P6RrEVZp6odzKirP~6J19GHrXICkJmak8AX5oW9Ws3B8ktaJG4e4Yc6NVqcVU~Kiqimync9dEWg2Tj1HQ4elK6zY2D8jLM2qHz-iOKj5Lw4ZAneBnqjCgqHtHCbazx~i0gjqHtcsoF9hGIthfo7s6dArY3a~jfdwyJ9zp5dj3-zrPzKDGtp7XgDLd2z8qbUsDtohULwS5SnVfN~3NtVI2n~0Zovz528Y8NCue09N9lyGOfDjcw-9tO9kLrYvHG9qv4r-VZL4xp5R5mbCnPi1c5TGjoxKoqN-mXDjg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782683"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782683/Platelet_rich_Plasma_and_Mesenchymal_Stem_Cells_Local_Infiltration_Promote_Functional_Recovery_and_Histological_Repair_of_Experimentally_Transected_Sciatic_Nerves_in_Rats"><img alt="Research paper thumbnail of Platelet-rich Plasma and Mesenchymal Stem Cells Local Infiltration Promote Functional Recovery and Histological Repair of Experimentally Transected Sciatic Nerves in Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/81573061/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782683/Platelet_rich_Plasma_and_Mesenchymal_Stem_Cells_Local_Infiltration_Promote_Functional_Recovery_and_Histological_Repair_of_Experimentally_Transected_Sciatic_Nerves_in_Rats">Platelet-rich Plasma and Mesenchymal Stem Cells Local Infiltration Promote Functional Recovery and Histological Repair of Experimentally Transected Sciatic Nerves in Rats</a></div><div class="wp-workCard_item"><span>Cureus</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The number of counted neural axons at the area distal to the nerve repair site were significantly...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The number of counted neural axons at the area distal to the nerve repair site were significantly repetitive (p<0.05) in both the PRP and MSC groups when compared with the control group. Conclusions Both PRP and MSCs appear to play an essential role in the enhancement of nerve repair in terms of functionality and histology. MSCs group demonstrated a positive effect, whereas the PRP group showed statistically significant better results.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e4afccad900dc669a5784b93e587e931" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573061,"asset_id":72782683,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573061/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782683"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782683"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782683; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782683]").text(description); $(".js-view-count[data-work-id=72782683]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782683; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782683']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e4afccad900dc669a5784b93e587e931" } } $('.js-work-strip[data-work-id=72782683]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782683,"title":"Platelet-rich Plasma and Mesenchymal Stem Cells Local Infiltration Promote Functional Recovery and Histological Repair of Experimentally Transected Sciatic Nerves in Rats","internal_url":"https://www.academia.edu/72782683/Platelet_rich_Plasma_and_Mesenchymal_Stem_Cells_Local_Infiltration_Promote_Functional_Recovery_and_Histological_Repair_of_Experimentally_Transected_Sciatic_Nerves_in_Rats","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573061,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573061/thumbnails/1.jpg","file_name":"1590337648-20200524-31511-e7j54d.pdf","download_url":"https://www.academia.edu/attachments/81573061/download_file","bulk_download_file_name":"Platelet_rich_Plasma_and_Mesenchymal_Ste.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573061/1590337648-20200524-31511-e7j54d-libre.pdf?1646226189=\u0026response-content-disposition=attachment%3B+filename%3DPlatelet_rich_Plasma_and_Mesenchymal_Ste.pdf\u0026Expires=1740485755\u0026Signature=YTHyjBeRf2pvQzHqmA7csZH3dycZeOyjjExrmkbNofPWFmrZWqmLG~bKCMb8ElDTtfA-SFNGUfvGmS07MmgVxwfVfMv3AybGkfUKTx2n4HGtBiOOP5t4y1DMQosinJKMlwgTGrz6PFkSvwPP-6wG6j17ruqWSQjrmwSsRKhBt0wx1zQIYw-RZ2QY0-uKd5XoiKkl6eMqu8Il4SxBt~rQoUqZExKh8dGYVL~WYKHRgdZ5~hhXbuw~uToZGxpMYwqhfEKtVF9SA-B9IN7lH1maoyWgExy5DGEHGAZzJYIcJ5XYVaxyS8qZ3r2zjou9djfbyRYUb2tSybRcu3vYD7UO8w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782674"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782674/Biglycan_Regulates_MG63_Osteosarcoma_Cell_Growth_Through_a_LPR6_%CE%B2_Catenin_IGFR_IR_Signaling_Axis"><img alt="Research paper thumbnail of Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis" class="work-thumbnail" src="https://attachments.academia-assets.com/81573050/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782674/Biglycan_Regulates_MG63_Osteosarcoma_Cell_Growth_Through_a_LPR6_%CE%B2_Catenin_IGFR_IR_Signaling_Axis">Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis</a></div><div class="wp-workCard_item"><span>Frontiers in oncology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone homeostas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone homeostasis and development as well as in bone pathology. In the present study biglycan was identified as a positive regulator of MG63 osteosarcoma cell growth ( ≤ 0.001). IGF-I was shown to increase biglycan expression ( ≤ 0.01), whereas biglycan-deficiency attenuated significantly both basal and IGF-I induced cell proliferation of MG63 cells ≤ 0.001; ≤ 0.01, respectively). These effects were executed through the IGF-IR receptor whose activation was strongly attenuated ( ≤ 0.01) in biglycan-deficient MG63 cells. Biglycan, previously shown to regulate Wnt/β-catenin pathway, was demonstrated to induce a significant increase in β-catenin protein expression evident at cytoplasmic ( ≤ 0.01), membrane ( ≤ 0.01), and nucleus fractions in MG63 cells ( ≤ 0.05). As demonstrated by immunofluorescence, increase in β-catenin expression is attributed to co-localization of biglycan with the Wnt co-receptor low...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a9229d18a6afdaac31ebd3e02c376d54" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573050,"asset_id":72782674,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573050/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782674"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782674"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782674; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782674]").text(description); $(".js-view-count[data-work-id=72782674]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782674; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782674']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a9229d18a6afdaac31ebd3e02c376d54" } } $('.js-work-strip[data-work-id=72782674]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782674,"title":"Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis","internal_url":"https://www.academia.edu/72782674/Biglycan_Regulates_MG63_Osteosarcoma_Cell_Growth_Through_a_LPR6_%CE%B2_Catenin_IGFR_IR_Signaling_Axis","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573050,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573050/thumbnails/1.jpg","file_name":"11fdecf7a3eb292ef1b3afe97296039b76d1.pdf","download_url":"https://www.academia.edu/attachments/81573050/download_file","bulk_download_file_name":"Biglycan_Regulates_MG63_Osteosarcoma_Cel.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573050/11fdecf7a3eb292ef1b3afe97296039b76d1-libre.pdf?1646226191=\u0026response-content-disposition=attachment%3B+filename%3DBiglycan_Regulates_MG63_Osteosarcoma_Cel.pdf\u0026Expires=1740485755\u0026Signature=Sm~ZNyYicLorFp4vPQs29yjGeNvEu8YwZOsPxlWd~QdcuyOhROuq5ZJh40gtwVz~9V6umJYi~TwGhlPv4tHYTl75qic4Z-K7JJY~cqcLla8Zi-f0zmpe8CCB11u1rjfcduaQn4eWnuxZMPfif~GDgb-jGKfeb0MeLl~lkoxYX5J8f1uabJy2LnNn~ZHsDOYHU4qQ~vsFdBNDuLULeI1jKyXeycjXZwiwJGALURUZSA8bja0Sx-FlaWtLzVMl6jnzlYh95rGXc3iat2xg7KvmFWpXOv7ZRxYp0849s5eoeJbyt28V~QO1CDgZT9YSCDrsL2z3xGMl5LjEXhlbp-4~SQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782664"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782664/Western_type_diet_differentially_modulates_osteoblast_osteoclast_and_lipoblast_differentiation_and_activation_in_a_background_of_APOE_deficiency"><img alt="Research paper thumbnail of Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency" class="work-thumbnail" src="https://attachments.academia-assets.com/81573060/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782664/Western_type_diet_differentially_modulates_osteoblast_osteoclast_and_lipoblast_differentiation_and_activation_in_a_background_of_APOE_deficiency">Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency</a></div><div class="wp-workCard_item"><span>Laboratory investigation; a journal of technical methods and pathology</span><span>, Jan 11, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During the past few years, considerable evidence has uncovered a strong relationship between fat ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During the past few years, considerable evidence has uncovered a strong relationship between fat and bone metabolism. Consequently, alterations in plasma lipid metabolic pathways strongly affect bone mass and quality. We recently showed that the deficiency of apolipoprotein A-1 (APOA1), a central regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, results in reduced bone mass in C57BL/6 mice. It is documented that apolipoprotein E (APOE), a lipoprotein know for its atheroprotective functions and de novo biogenesis of HDL-C, is associated with the accumulation of fat in the liver and other organs and regulates bone mass in mice. We further studied the mechanism of APOE in bone metabolism using well-characterized APOE knockout mice. We found that bone mass was remarkably reduced in APOE deficient mice fed Western-type diet (WTD) compared to wild type counterparts. Static (microCT-based) and dynamic histomorphometry showed that the reduced bone mass in APOΕ mice is at...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a2a6bb24ef32dd62d18e242e2d2f6f8e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573060,"asset_id":72782664,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573060/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782664"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782664"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782664; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782664]").text(description); $(".js-view-count[data-work-id=72782664]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782664; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782664']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a2a6bb24ef32dd62d18e242e2d2f6f8e" } } $('.js-work-strip[data-work-id=72782664]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782664,"title":"Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency","internal_url":"https://www.academia.edu/72782664/Western_type_diet_differentially_modulates_osteoblast_osteoclast_and_lipoblast_differentiation_and_activation_in_a_background_of_APOE_deficiency","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573060,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573060/thumbnails/1.jpg","file_name":"s41374-018-0107-7.pdf","download_url":"https://www.academia.edu/attachments/81573060/download_file","bulk_download_file_name":"Western_type_diet_differentially_modulat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573060/s41374-018-0107-7-libre.pdf?1646226187=\u0026response-content-disposition=attachment%3B+filename%3DWestern_type_diet_differentially_modulat.pdf\u0026Expires=1740485755\u0026Signature=afyiqJe-zsnKSNJV4X0xO0EWzZ7uRXwJ5eW-5y~lobTcnzTt3L3TupVHkCP9WppcB8s5R6sEJj9hZiwPIkkLEllQ0RKP5PvjIOsBTokiVISlwew~AvP8foGTV3Hcc8~Am9N41YZHuGAh7704TEMD8ZLT1y4PIuEGE~SWLdrPxzAiHZxRfHfR2OX0w7UTZTeEbBFQQ9FcbngWeiIxmDfp9W7BhCffB-Si3xmRTWUnAkAENvVw3HMw0hYfSk5W6mp3Sy6y0bkw7b-rUtVJp6u3S0ZgVN2b2u5EZbTTeLsNB0LNB~ybsZbdGJVmzgN9U1OT6nV5S-sLAtOqmNNu6BloTQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782657"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782657/IGF_I_regulates_HT1080_fibrosarcoma_cell_migration_through_a_syndecan_2_Erk_ezrin_signaling_axis"><img alt="Research paper thumbnail of IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis" class="work-thumbnail" src="https://attachments.academia-assets.com/81573035/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782657/IGF_I_regulates_HT1080_fibrosarcoma_cell_migration_through_a_syndecan_2_Erk_ezrin_signaling_axis">IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis</a></div><div class="wp-workCard_item"><span>Experimental cell research</span><span>, Dec 1, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fibrosarcoma is a tumor of mesenchymal origin, originating from fibroblasts. IGF-I is an anabolic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fibrosarcoma is a tumor of mesenchymal origin, originating from fibroblasts. IGF-I is an anabolic growth factor which exhibits significant involvement in cancer progression. In this study, we investigated the possible participation of syndecan-2 (SDC-2), a cell membrane heparan sulfate (HS) proteoglycan on IGF-I dependent fibrosarcoma cell motility. Our results demonstrate that SDC-2-deficient HT1080 cells exhibit attenuated IGF-I-dependent chemotactic migration (p &lt; 0.001). SDC-2 was found to co-localize to IGF-I receptor (IGF-IR) in a manner dependent on IGF-I activity (P ≤ 0.01). In parallel, the downregulation of SDC-2 significantly inhibited both basal and due to IGF-I action ERK1/2 activation, (p &lt; 0.001). The phosphorylation levels of ezrin (Thr567), which is suggested to act as a signaling bridge between the cellular membrane receptors and actin cytoskeleton, were strongly enhanced by IGF-I at both 1h and 24h (p &lt; 0.05; p &lt; 0.01). The formation of an immunoprecip...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5c39663c0dd0e5358a8785db6e8334ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573035,"asset_id":72782657,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573035/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782657"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782657"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782657; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782657]").text(description); $(".js-view-count[data-work-id=72782657]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782657; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782657']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5c39663c0dd0e5358a8785db6e8334ec" } } $('.js-work-strip[data-work-id=72782657]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782657,"title":"IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis","internal_url":"https://www.academia.edu/72782657/IGF_I_regulates_HT1080_fibrosarcoma_cell_migration_through_a_syndecan_2_Erk_ezrin_signaling_axis","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573035,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573035/thumbnails/1.jpg","file_name":"IGF-I_20regulates_20HT1080.pdf","download_url":"https://www.academia.edu/attachments/81573035/download_file","bulk_download_file_name":"IGF_I_regulates_HT1080_fibrosarcoma_cell.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573035/IGF-I_20regulates_20HT1080-libre.pdf?1646226194=\u0026response-content-disposition=attachment%3B+filename%3DIGF_I_regulates_HT1080_fibrosarcoma_cell.pdf\u0026Expires=1740485755\u0026Signature=ELmrYvc8Cxx7lmFT1AzNMOVq3Olqp06H-C0SBxBP-2~ofcMZWRYIUHDyiTTLQQSpm7AvBVVds9xO4UiFCAjuCbCLkzxicdrKCs5rPDvNB6wJStpNQQRIy~0xIJbclcil5t9vNYuND~~s4vxFGDyEdLoL5SHRG0zrDHy3v2lM4CJedASX2IviKPOarogjvN4i7962~oZZKSUnIPl2Qotllsmi5fi5QzLDeM~D28is2WcQo8nbmeeUGVoIPwoHxWrN6uHEkEQ8ow5~2QC4LuFJvgHBRw-~rXmERBLrubEWfSLbCB0spDOnjJMnOiZIGJoKpoB8AueR0zD9RdFDgOylCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782646"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782646/High_density_lipoprotein_HDL_metabolism_and_bone_mass"><img alt="Research paper thumbnail of High-density lipoprotein (HDL) metabolism and bone mass" class="work-thumbnail" src="https://attachments.academia-assets.com/81573044/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782646/High_density_lipoprotein_HDL_metabolism_and_bone_mass">High-density lipoprotein (HDL) metabolism and bone mass</a></div><div class="wp-workCard_item"><span>Journal of Endocrinology</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is well appreciated that high-density lipoprotein (HDL) and bone physiology and pathology are ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is well appreciated that high-density lipoprotein (HDL) and bone physiology and pathology are tightly linked. Studies, primarily in mouse models, have shown that dysfunctional and/or disturbed HDL can affect bone mass through many different ways. Specifically, reduced HDL levels have been associated with the development of an inflammatory microenvironment that affects the differentiation and function of osteoblasts. In addition, perturbation in metabolic pathways of HDL favors adipoblastic differentiation and restrains osteoblastic differentiation through, among others, the modification of specific bone-related chemokines and signaling cascades. Increased bone marrow adiposity also deteriorates bone osteoblastic function and thus bone synthesis, leading to reduced bone mass. In this review, we present the current knowledge and the future directions with regard to the HDL–bone mass connection. Unraveling the molecular phenomena that underline this connection will promote the deepe...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5a92f2501d3f17ade241659527b6e3a1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573044,"asset_id":72782646,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573044/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782646"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782646"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782646; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782646]").text(description); $(".js-view-count[data-work-id=72782646]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782646; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782646']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5a92f2501d3f17ade241659527b6e3a1" } } $('.js-work-strip[data-work-id=72782646]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782646,"title":"High-density lipoprotein (HDL) metabolism and bone mass","internal_url":"https://www.academia.edu/72782646/High_density_lipoprotein_HDL_metabolism_and_bone_mass","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573044,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573044/thumbnails/1.jpg","file_name":"a7e9fedd1e08c31995d5394e89099750e0bb.pdf","download_url":"https://www.academia.edu/attachments/81573044/download_file","bulk_download_file_name":"High_density_lipoprotein_HDL_metabolism.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573044/a7e9fedd1e08c31995d5394e89099750e0bb-libre.pdf?1646226191=\u0026response-content-disposition=attachment%3B+filename%3DHigh_density_lipoprotein_HDL_metabolism.pdf\u0026Expires=1740485755\u0026Signature=gun1jUUZYz2kZQnqtb6LJx8p8zHu9s0jQjfj9cwmRb15kqtlh9fLL60vFHdlSqLyk4jOoqgoaZDvRW0iQzjvLgPBvYxbNDUXAyHfC2pJI2xPnKPbyZRyMbcwQ8RQvEee4wQXntrkRRQ3bDhv-3phyVIglS6xzs-TAfXRErrlljcXZ9TO5lStsdWwWMu35Bfms~mTzcVPrvG4Me3dbaOoTXs06yI-3xlAmteJXdihFwK41F4M-r-GcKA6FIZwbZrW-9MpMiIn~BsafG2FywVagbzdp7I8HYupsBOMCN8g05wAe6e4InLy2MJziblzZjVn4rccUXDjwpJ~i2ugEOEMFg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782641"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782641/Novel_evidence_that_ApoA_1_deficiency_facilitates_HSC_mobilization_and_differentiation_and_halts_HSC_quiescence_and_self_renewal_in_mice"><img alt="Research paper thumbnail of Novel evidence that ApoA-1 deficiency facilitates HSC mobilization and differentiation and halts HSC quiescence and self-renewal in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/81573025/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782641/Novel_evidence_that_ApoA_1_deficiency_facilitates_HSC_mobilization_and_differentiation_and_halts_HSC_quiescence_and_self_renewal_in_mice">Novel evidence that ApoA-1 deficiency facilitates HSC mobilization and differentiation and halts HSC quiescence and self-renewal in mice</a></div><div class="wp-workCard_item"><span>Bone Abstracts</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The expression of CLCX12 was significantly reduced, while the expression CXCR4 was greatly augmen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The expression of CLCX12 was significantly reduced, while the expression CXCR4 was greatly augmented (possibly via feedback cell reactionmechanism) in the WBMCs of the ApoA-I-/compared to the WT mice. 2.WBMCs from ApoA-I-/mice displayed strongly increased mRNA levels of Jagged-1 compared to the WT mice. 3.Osteopontin mRNA expression levels were decreased in apoA-1-/mice in contrast to the WT mice. 4.Flow cytometry revealed no significant differences in CXCR4 expression on HSCs of both study groups. CONCLUSIONS: The present study suggests for the first time that ApoA-I deficiency (and thus impaired HDL) halts HSC maintenance and quiescence, whereas it promotes HSC differentiation suggesting that it may be involved in the pathobiology of hematologic malignancies and possibly bone metastases.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f614a6c30c4b32dc058c26229a6b6b1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573025,"asset_id":72782641,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573025/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782641"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782641"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782641; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782641]").text(description); $(".js-view-count[data-work-id=72782641]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782641; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782641']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f614a6c30c4b32dc058c26229a6b6b1" } } $('.js-work-strip[data-work-id=72782641]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782641,"title":"Novel evidence that ApoA-1 deficiency facilitates HSC mobilization and differentiation and halts HSC quiescence and self-renewal in mice","internal_url":"https://www.academia.edu/72782641/Novel_evidence_that_ApoA_1_deficiency_facilitates_HSC_mobilization_and_differentiation_and_halts_HSC_quiescence_and_self_renewal_in_mice","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573025,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573025/thumbnails/1.jpg","file_name":"7baf47528cbb6fb00f4d46364651e73a503b.pdf","download_url":"https://www.academia.edu/attachments/81573025/download_file","bulk_download_file_name":"Novel_evidence_that_ApoA_1_deficiency_fa.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573025/7baf47528cbb6fb00f4d46364651e73a503b-libre.pdf?1646226198=\u0026response-content-disposition=attachment%3B+filename%3DNovel_evidence_that_ApoA_1_deficiency_fa.pdf\u0026Expires=1740485755\u0026Signature=a5wYwoktVLuCqcqeSYA9r3Du~-8OBET22LXA6IKnToCVW26q1fj6wnFRhIrIBwvDVbRHPBI5hhDyfzBZhylIUD3OSb8P2sT5kJOIB9tk6DU3HG02nfufWRRnCI~p2gO~Cx5MO4ZcRM7rPt7q2fmYOj3oF76WIcVVZON5JTIl4acycgCPeh-RSievBDEdsQlxjK4FvXCsPdqB3MDsd2FhJEM-qdxSzvydPmC~x2txf7FRAoG~rkTk4ag84OEwHGCbW5RJiI4ZP5tDpSMJZhL9QGanXwO2kdHRMbwb~uHsSK7Ur~AS6L7bUOLodq4LMgRMe-PGiCMmqe0n65dKa36kEg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782634"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782634/Cancer_of_unknown_primary_ultimately_diagnosed_as_male_breast_cancer_A_rare_case_report"><img alt="Research paper thumbnail of Cancer of unknown primary ultimately diagnosed as male breast cancer: A rare case report" class="work-thumbnail" src="https://attachments.academia-assets.com/81573019/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782634/Cancer_of_unknown_primary_ultimately_diagnosed_as_male_breast_cancer_A_rare_case_report">Cancer of unknown primary ultimately diagnosed as male breast cancer: A rare case report</a></div><div class="wp-workCard_item"><span>Molecular and Clinical Oncology</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancers of unknown primary (CUP) constitute a significant diagnostic and therapeutic challenge fo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancers of unknown primary (CUP) constitute a significant diagnostic and therapeutic challenge for clinicians and a frequent cause of cancer-related mortality in Western countries. Immunohistochemistry assays are commonly used to identify the primary cancer, but fail in approximately one-third of cases. The identification of the possible origin of CUP is crucial, as it may help select the appropriate treatment options. We herein present the case of a 54-year-old male patient, who presented with lower back pain in June, 2013. Following a thorough investigation, the clinical and pathological findings could not identify the primary cancer, leading towards a misdiagnosis. Ultimately, microRNA testing of the resected spine lesion was able to identify the primary tumor as male breast cancer and allow for optimal treatment of the patient.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c7ba8d7318a172de984a9c8a71d4a6c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573019,"asset_id":72782634,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573019/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782634"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782634]").text(description); $(".js-view-count[data-work-id=72782634]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782634']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c7ba8d7318a172de984a9c8a71d4a6c5" } } $('.js-work-strip[data-work-id=72782634]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782634,"title":"Cancer of unknown primary ultimately diagnosed as male breast cancer: A rare case report","internal_url":"https://www.academia.edu/72782634/Cancer_of_unknown_primary_ultimately_diagnosed_as_male_breast_cancer_A_rare_case_report","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573019,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573019/thumbnails/1.jpg","file_name":"7749a7cba90bb38d4d2c50aa1b1f91b1f8cd.pdf","download_url":"https://www.academia.edu/attachments/81573019/download_file","bulk_download_file_name":"Cancer_of_unknown_primary_ultimately_dia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573019/7749a7cba90bb38d4d2c50aa1b1f91b1f8cd-libre.pdf?1646226198=\u0026response-content-disposition=attachment%3B+filename%3DCancer_of_unknown_primary_ultimately_dia.pdf\u0026Expires=1740485755\u0026Signature=Ish7HAp2pdK1n1pIQeftGWmS64webSGa6GLdEF28zAw0QAxCTN-dD9kr20k4GaL~6W8gsnsTRI2NV1dL7~TIYCOuAAcvzLeoTm1vW5C4qUtS1QkgYq2eKPPYCTzdSxeGl34eBWddLnrv6Sh43w3VPfX5wXDsxm5UjFEaYRhtyYjBF0RuaEOPmX5eunFqlxKdduJAg2pQ9KvZI~9vaLDz4eUbTm14a6Q58oOnrf~HqfEjj4LUHYb4C4UxgUz5xIBpMNLGCUoIG8H~Q0-TE62LYHXk69ryO5XsElEYprWlidujmLrvFKdnQHawyKejqfgSpvcjnHkHG32iFacRa~v3rw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782621"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782621/B_cell_depletion_therapy_upregulates_Dkk_1_skin_expression_in_patients_with_systemic_sclerosis_association_with_enhanced_resolution_of_skin_fibrosis"><img alt="Research paper thumbnail of B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis" class="work-thumbnail" src="https://attachments.academia-assets.com/81573026/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782621/B_cell_depletion_therapy_upregulates_Dkk_1_skin_expression_in_patients_with_systemic_sclerosis_association_with_enhanced_resolution_of_skin_fibrosis">B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis</a></div><div class="wp-workCard_item"><span>Arthritis research & therapy</span><span>, Jan 21, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Rituximab (RTX) may favorably affect skin and lung fibrosis in patients with systemic sclerosis (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Rituximab (RTX) may favorably affect skin and lung fibrosis in patients with systemic sclerosis (SSc); however, the underlying molecular mechanisms remain unknown. We aimed to explore the hypothesis that RTX may mediate its antifibrotic effects by regulating the expression of Dickkopf-1 (Dkk-1), an inhibitor of the Wnt pathway. Fourteen patients with SSc and five healthy subjects were recruited. Dkk-1 expression was immunohistochemically assessed in skin biopsies obtained from 11 patients with SSc (8 treated with RTX and 3 with standard treatment), whereas DKK1 gene expression was assessed in 3 patients prior to and following RTX administration. In baseline biopsies obtained from all patients with SSc but not in healthy subjects, Dkk-1 was undetectable in skin fibroblasts. Following RTX treatment, four out of eight patients had obvious upregulation of Dkk-1 skin expression. Similarly, RTX treatment correlated with a significant 4.8-fold upregulation of DKK1 gene expression (p = 0.03...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="12a76c863946672ca8ea7d7351546284" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573026,"asset_id":72782621,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573026/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782621"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782621"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782621; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782621]").text(description); $(".js-view-count[data-work-id=72782621]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782621; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782621']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "12a76c863946672ca8ea7d7351546284" } } $('.js-work-strip[data-work-id=72782621]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782621,"title":"B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis","internal_url":"https://www.academia.edu/72782621/B_cell_depletion_therapy_upregulates_Dkk_1_skin_expression_in_patients_with_systemic_sclerosis_association_with_enhanced_resolution_of_skin_fibrosis","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573026,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573026/thumbnails/1.jpg","file_name":"pmc4875588.pdf","download_url":"https://www.academia.edu/attachments/81573026/download_file","bulk_download_file_name":"B_cell_depletion_therapy_upregulates_Dkk.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573026/pmc4875588-libre.pdf?1646226196=\u0026response-content-disposition=attachment%3B+filename%3DB_cell_depletion_therapy_upregulates_Dkk.pdf\u0026Expires=1740485755\u0026Signature=a7emp5sQ0EBZm5x0WM2sxTxx2xBXj9MkY1v8pT-AlzV4xKif3rWLpbZoNkCB7f6q0qG~1kz6hEf6tKaciLXyPbiBAlqynnZCW0RIR0p3Lo5MMnN8LtNz-PcxCGxct00wwSj82HpSTblonPwzUVwoAzbcHKwgtyZLptMbcffYSBTu8r2qRtqsyQ7cniyQmGmap2cMxzsOAd-Iz8K6oB~f1wqLk55pmBhfWXpwkb~VEd9Em5acYTbCAC8YncGLKO6tkVLj27Gun4sCjvNkOZ4bAnloCSkvZNqg5e9EVZ8ehXLIheeTGNwNPLGJm3RQMqs1yeCJF5bNYhAkHCTQS08oxA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782615"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782615/Giant_Cell_Tumor_of_the_Patella_Tendon_Sheath_Presenting_as_a_Painful_Locked_Knee"><img alt="Research paper thumbnail of Giant Cell Tumor of the Patella Tendon Sheath Presenting as a Painful Locked Knee" class="work-thumbnail" src="https://attachments.academia-assets.com/81573003/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782615/Giant_Cell_Tumor_of_the_Patella_Tendon_Sheath_Presenting_as_a_Painful_Locked_Knee">Giant Cell Tumor of the Patella Tendon Sheath Presenting as a Painful Locked Knee</a></div><div class="wp-workCard_item"><span>American Journal of Case Reports</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: Rare disease Background: The giant cell tumor of the tendon sheath (GCT-TS) is a benig...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: Rare disease Background: The giant cell tumor of the tendon sheath (GCT-TS) is a benign proliferative synovial tumor manifesting as an intra-articular solitary nodule. When it involves the infrapatellar fat pad it can present acutely as a painful locked knee. Case Report: A 26-year-old white male presented with a 2-week history of painful locking in his right knee. Clinical examination revealed lack of extension by approximately 20°. To help establish the diagnosis, an MRI scan of the right knee was performed, showing a large (5×4×2 cm), oval, well-circumscribed mass with a low-intensity homogenous signal. The size of the mass prohibited the removal by arthroscopy and we therefore proceeded with an open arthrotomy. Histological examination showed a tendosynovial giant cell tumor of the patella tendon sheath. At the latest follow-up, 2 years postoperatively, there was no local tumor recurrence. Conclusions: These rare tumorous lesions should be included in the differential diagnosis of painful locking knee, especially in the absence of definite traumatic history.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4efce2a9ce6fa660c1f005146b8d0ea5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573003,"asset_id":72782615,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573003/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782615"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782615"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782615; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782615]").text(description); $(".js-view-count[data-work-id=72782615]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782615; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782615']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4efce2a9ce6fa660c1f005146b8d0ea5" } } $('.js-work-strip[data-work-id=72782615]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782615,"title":"Giant Cell Tumor of the Patella Tendon Sheath Presenting as a Painful Locked Knee","internal_url":"https://www.academia.edu/72782615/Giant_Cell_Tumor_of_the_Patella_Tendon_Sheath_Presenting_as_a_Painful_Locked_Knee","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573003,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573003/thumbnails/1.jpg","file_name":"b7da8bbd4276b6ab74625663cea1558423bb.pdf","download_url":"https://www.academia.edu/attachments/81573003/download_file","bulk_download_file_name":"Giant_Cell_Tumor_of_the_Patella_Tendon_S.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573003/b7da8bbd4276b6ab74625663cea1558423bb-libre.pdf?1646226203=\u0026response-content-disposition=attachment%3B+filename%3DGiant_Cell_Tumor_of_the_Patella_Tendon_S.pdf\u0026Expires=1740485755\u0026Signature=TEpjxdSgv-CCd2lyOV7PNVP0eYTFjGpxEs~eA-xrjFEvAvfJ0bJV3Li9KfU-Q-BYNTSy6yDZK5xH6hIWdRjzO3KKnSue7OuGA5lHR0WIWpvBLnfZ2GO703a8ElgC8mvSU2Yx3m-Ke~1OH-dVpXi8oGTtrKrp0UQLnUEDRXlyuRypJePIjV~Oycdbvae2Ga0xD-FZnhb7lXAeWp090jzhvI0n9Q5FwZwVOiDf7n2X0E4Fs4QZ2gQd-LQ7q-OtKCdgo5zXgWrC1~Tdr6E2LqVFwGdIv0i3tLJzctsdyqe3yZncSaQuA3ITKIDHNQa29-WIhlFWzIzk-0jW37z8QAYu3A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782605"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782605/Investigation_on_Toxicity_and_Teratogenicity_in_Rats_of_a_Retinoid_Polyamine_Conjugate_with_Potent_Anti_Inflammatory_Properties"><img alt="Research paper thumbnail of Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties" class="work-thumbnail" src="https://attachments.academia-assets.com/81572998/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782605/Investigation_on_Toxicity_and_Teratogenicity_in_Rats_of_a_Retinoid_Polyamine_Conjugate_with_Potent_Anti_Inflammatory_Properties">Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties</a></div><div class="wp-workCard_item"><span>Birth Defects Research Part B: Developmental and Reproductive Toxicology</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Previous studies have shown that N 1 ,N 12-bis(all-trans-retinoyl)spermine (RASP), a retinoid ana...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Previous studies have shown that N 1 ,N 12-bis(all-trans-retinoyl)spermine (RASP), a retinoid analog, inhibits RNase P activity and angiogenesis in the chicken embryo chorioallantoic membrane, demonstrates anti-tumor activity on prostate cancer cells, and acts as anti-inflammatory agent, being more effective and less toxic than all-trans retinoic acid. In an attempt to further characterize the biological profile of RASP, we tested its effects on organ toxicity and teratogenicity by daily oral gavage of RASP at a level of 50 mg/Kg of body weight in two generations of rats. We found that this compound does not induce changes to the body growth, the appearance of physical features, and the animal's reflexes. Additionally, no substantial histopathological lesions were found in brain, heart, lung, thymus, liver, thyroid gland, adrenal gland, pituitary gland, kidneys, spleen, skin, femora, prostate, testis, epididymis, vagina, uterus, and ovaries of RASP-treated animals. These results suggest RASP, as a promising lead compound for the treatment of several dermatological disorders and certain cancer types, has apparently minimal toxic side-effects as revealed in this two-generation reproduction study in rats.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9dda7bdadaed34f65e2f4d07b151c396" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572998,"asset_id":72782605,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572998/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782605"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782605"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782605; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782605]").text(description); $(".js-view-count[data-work-id=72782605]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782605; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782605']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9dda7bdadaed34f65e2f4d07b151c396" } } $('.js-work-strip[data-work-id=72782605]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782605,"title":"Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties","internal_url":"https://www.academia.edu/72782605/Investigation_on_Toxicity_and_Teratogenicity_in_Rats_of_a_Retinoid_Polyamine_Conjugate_with_Potent_Anti_Inflammatory_Properties","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572998,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572998/thumbnails/1.jpg","file_name":"bdrb.pdf","download_url":"https://www.academia.edu/attachments/81572998/download_file","bulk_download_file_name":"Investigation_on_Toxicity_and_Teratogeni.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572998/bdrb-libre.pdf?1646226204=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_on_Toxicity_and_Teratogeni.pdf\u0026Expires=1740485755\u0026Signature=SMGanaet3M3ojyey8DRPjsjmBpwtccimp-s5RiObUx0HqCDc-n20IT6SBs2PslfVnGz3-dmXff8~clfpKZwP54NvAnYt7YQdowCY2G7IxCntIJtKRkYnkBy3TTbePy9aT5mXkhdXn-8wEd8JA~k-O9HRoxufy0wqlIFg4WyeD61bm0AEhq3idcK8PwR26XhPwVTcg-BjoXTRPRSFB1Sr2Iq~3nG9UOoDVwfG5491C23cKH7NdiwXU0C3~kj~HUw2~Irav2xXByd6fRcYCYHhXPV-WLPfRAuA1jr2PVSCHnHJFtPVb6~LH23GkV1jm5aGnnr~-4Hr8BgKQNjxChJzoQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782593"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782593/Increased_Expression_of_Serglycin_in_Specific_Carcinomas_and_Aggressive_Cancer_Cell_Lines"><img alt="Research paper thumbnail of Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines" class="work-thumbnail" src="https://attachments.academia-assets.com/81572875/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782593/Increased_Expression_of_Serglycin_in_Specific_Carcinomas_and_Aggressive_Cancer_Cell_Lines">Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>BioMed Research International</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present pilot study, we examined the presence of serglycin in lung, breast, prostate, and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present pilot study, we examined the presence of serglycin in lung, breast, prostate, and colon cancer and evaluated its expression in cell lines and tissues. We found that serglycin was expressed and constitutively secreted in culture medium in high levels in more aggressive cancer cells. It is worth noticing that aggressive cancer cells that harbor KRAS or EGFR mutations secreted serglycin constitutively in elevated levels. Furthermore, we detected the transcription of an alternative splice variant of serglycin lacking exon 2 in specific cell lines. In a limited number of tissue samples analyzed, serglycin was detected in normal epithelium but was also expressed in higher levels in advanced grade tumors as shown by immunohistochemistry. Serglycin staining was diffuse, granular, and mainly cytoplasmic. In some cancer cells serglycin also exhibited membrane and/or nuclear immunolocalization. Interestingly, the stromal cells of the reactive tumor stroma were positive for sergl...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9df1fa6eb5558b1f93acb28b9bc85531" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572875,"asset_id":72782593,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572875/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782593"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782593"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782593; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782593]").text(description); $(".js-view-count[data-work-id=72782593]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782593; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782593']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9df1fa6eb5558b1f93acb28b9bc85531" } } $('.js-work-strip[data-work-id=72782593]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782593,"title":"Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines","internal_url":"https://www.academia.edu/72782593/Increased_Expression_of_Serglycin_in_Specific_Carcinomas_and_Aggressive_Cancer_Cell_Lines","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572875,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572875/thumbnails/1.jpg","file_name":"690721.pdf","download_url":"https://www.academia.edu/attachments/81572875/download_file","bulk_download_file_name":"Increased_Expression_of_Serglycin_in_Spe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572875/690721-libre.pdf?1646226239=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Expression_of_Serglycin_in_Spe.pdf\u0026Expires=1740485755\u0026Signature=JIQHDcoE7yfP4puZ6C-1XcCdqP9HZ88NGJNBr2bIe0WbtbltF6pUuzNPbef-NLbHusffyoxhRyf0fnjVNMUHf9el2gtqV6gyFcu96uirxUBREzx2wARJwnNOA1zc90LLzVZ7UZHh-aeuxbj4r5nJ-dlXRokkfjFLYilhOPA~0jq0NtqhayzllcwQpvHU2Um42RtWh~KicKCnIkRcIU2th41SBnYZp5vnweDXX3nLu6Jl2gPWCP5xR-g0XdpsxiE0fSbh8DD5lPiewY1TIh8wFT8KW3SV8Ml-Y0bXr3PHrGflRSp-5Kc3-OYT3Q1bn2WuF1qLdM7l9K4AeYxuZQ~reQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":81572874,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572874/thumbnails/1.jpg","file_name":"690721.pdf","download_url":"https://www.academia.edu/attachments/81572874/download_file","bulk_download_file_name":"Increased_Expression_of_Serglycin_in_Spe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572874/690721-libre.pdf?1646226239=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Expression_of_Serglycin_in_Spe.pdf\u0026Expires=1740485756\u0026Signature=XM4t0ev6hr8FXugt3xpyireOQohcJPHE-Z-Sa~SyZ4nukwjbLdpEF~P4IHYIodG9Dhrz7Ohyw7X8CiREK~3DPR9GyBqJ3genbZuCF-UGaUNZr6m5vDi5D27dWwb5di0PBnSBLdVyPsR~raH092dQ9UojDOuSsoftQtbo40jEfqnLVGWmOBIIn7EmP6hgT093rveaPf~jeIS0eKjbmYUw8VhsoRshwHcyHqVxldAKy3vwVpTvvSUNxJL3ILMseLFzxWailjdh7sAHcBTY2myhMCLmwpTdZjqpLJiolpWTW3QK5pO2JCBlSnOKUJkwTs74U5HIY8yAi~mp8FqVpj5Ccg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782584"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782584/Expression_of_vascular_endothelial_growth_factor_and_its_receptor_KDR_Flk_1_in_soft_tissue_sarcomas"><img alt="Research paper thumbnail of Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas" class="work-thumbnail" src="https://attachments.academia-assets.com/81572976/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782584/Expression_of_vascular_endothelial_growth_factor_and_its_receptor_KDR_Flk_1_in_soft_tissue_sarcomas">Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas</a></div><div class="wp-workCard_item"><span>Anticancer research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of the present study was to evaluate the association of vascular endothelial growth facto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of the present study was to evaluate the association of vascular endothelial growth factor (VEGF) and its receptor, KDR/Flk-1, with tumor grade, microvessel density (MVD) and clinical outcome in patients with soft tissue sarcomas (STSs). Tissue specimens of 28 patients with STSs were analyzed immunohistochemically using specific monoclonal antibodies. Tissue samples were obtained prior to any treatment. Half of the STSs exhibited strong expression of VEGF that was associated statistically significantly with high tumor grade. Strong expression of KDR/Flk-1 was detected in only 2 sarcomas. No association was demonstrated between VEGF and KDR/Flk-1 expression. MVD was significantly associated with tumor grade and was higher in sarcomas with strong VEGF expression. Limited data on clinical outcome precluded solid analyses for an association with disease progression. This study provides further evidence on the role of VEGF and MVD in tumor aggressiveness in STSs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="669fe8c6a72d2198f58aadad8b60c422" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572976,"asset_id":72782584,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572976/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782584]").text(description); $(".js-view-count[data-work-id=72782584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "669fe8c6a72d2198f58aadad8b60c422" } } $('.js-work-strip[data-work-id=72782584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782584,"title":"Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas","internal_url":"https://www.academia.edu/72782584/Expression_of_vascular_endothelial_growth_factor_and_its_receptor_KDR_Flk_1_in_soft_tissue_sarcomas","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572976,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572976/thumbnails/1.jpg","file_name":"1477-7819-3-2.pdf","download_url":"https://www.academia.edu/attachments/81572976/download_file","bulk_download_file_name":"Expression_of_vascular_endothelial_growt.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572976/1477-7819-3-2-libre.pdf?1646226211=\u0026response-content-disposition=attachment%3B+filename%3DExpression_of_vascular_endothelial_growt.pdf\u0026Expires=1740485756\u0026Signature=cc0QfMhhAt2SB5TVnZYSxiNWa0IG8vvbxOu~bJQgA03fJZQ7PgCLoTXtrsYVNryqSyO6Ugvh9905lM24Y3sbhOk3pca7GVQu~25KmO~mfZ4ehjPgvWz-xZtCntS8-swF0AuOcrF99wq6QRZnp4ijcdal1VD2mM5IXCfIYnD0q7MCruCEr~vPrmOK6xgVEfNPq5mSySt6LgGL9HgKbzNoOkVw0xPsXw4NwSo6AHJJwJGyQSF5uiBKr-Q~EbIdU7qsQh-9MKmOVKdoyXln-VPN1IzHJhS3QOz7IdmnRf6hrtcy62bPA~CRERX9xKfHSMPuUQSVoo9wXheqaFyZpgWADg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782578"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782578/The_inhibition_of_aromatase_alters_the_mechanical_and_rheological_properties_of_non_small_cell_lung_cancer_cell_lines_affecting_cell_migration"><img alt="Research paper thumbnail of The inhibition of aromatase alters the mechanical and rheological properties of non-small-cell lung cancer cell lines affecting cell migration" class="work-thumbnail" src="https://attachments.academia-assets.com/81572970/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782578/The_inhibition_of_aromatase_alters_the_mechanical_and_rheological_properties_of_non_small_cell_lung_cancer_cell_lines_affecting_cell_migration">The inhibition of aromatase alters the mechanical and rheological properties of non-small-cell lung cancer cell lines affecting cell migration</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tumor invasion and metastasis are key aspects of non-small cell lung cancer (NSCLC). During migra...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tumor invasion and metastasis are key aspects of non-small cell lung cancer (NSCLC). During migration, cells undergo mechanical alterations. The mechanical phenotype of breast cancer cells is correlated with aromatase gene expression. We have previously shown that targeting aromatase is a promising strategy for NSCLC. The aim of this study was to examine morphological and mechanical changes of NSCLC cells, upon treatment with aromatase inhibitor and correlate their ability to migrate and invade. In vitro experiments were performed using H23 and A549 NSCLC cell lines and exemestane was used for aromatase inhibition. We demonstrated that exemestane reduced H23 cell migration and invasion and caused changes in cell morphology including increased vacuolar structures and greater pleomorphism. In addition, exemestane changed the distribution of α-tubulin in H23 and A549 cells in a way that might destabilize microtubules polymerization. These effects were associated with increased cell viscosity and decreased elastic shear modulus. Although exemestane caused similar effects in A549 cells regarding viscosity and elastic shear modulus, it did not affect A549 cell migration and caused an increase in invasion. The increased invasion was in line with vimentin perinuclear localization. Our data show that the treatment of NSCLC cells with an aromatase inhibitor not only affects cell migration and invasion but also alters the mechanical properties of the cells. It suggests that the different origin of cancer cells is associated with different morphological characteristics and mechanical behavior.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="de7f8625d875c2d8cf4c9d279f6f412a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572970,"asset_id":72782578,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572970/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782578"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782578"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782578; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782578]").text(description); $(".js-view-count[data-work-id=72782578]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782578; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782578']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "de7f8625d875c2d8cf4c9d279f6f412a" } } $('.js-work-strip[data-work-id=72782578]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782578,"title":"The inhibition of aromatase alters the mechanical and rheological properties of non-small-cell lung cancer cell lines affecting cell migration","internal_url":"https://www.academia.edu/72782578/The_inhibition_of_aromatase_alters_the_mechanical_and_rheological_properties_of_non_small_cell_lung_cancer_cell_lines_affecting_cell_migration","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572970,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572970/thumbnails/1.jpg","file_name":"82769308.pdf","download_url":"https://www.academia.edu/attachments/81572970/download_file","bulk_download_file_name":"The_inhibition_of_aromatase_alters_the_m.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572970/82769308-libre.pdf?1646226212=\u0026response-content-disposition=attachment%3B+filename%3DThe_inhibition_of_aromatase_alters_the_m.pdf\u0026Expires=1740485756\u0026Signature=VaX6swwHMbkwH1VvVVs3OyDrAKiVyFrz6zAC-rgF-B7BH9kmhyElQnY7ZgBAhMNouhlFzIfSaLiyjKZW7paC3V8xX~SQeclKxHU-760CeK7bNTAJQsqxrf~D3QWnkL171uvZPg5JlAxTtemZrEx5KwCUy3LE7Q6rKrKngV0h3G-k~kzyeHs710hisFeL7v5-Qy0cZS3eDDybk8yvAIR0kCe4GO~Xs8EWXIJ0lK84UWttrX6QGBIsDhrYXMq3R8gwr84u-8VbCbxVs1D9WxOnQ6D92UAb5VTAobuY1cYTYw7T8XA27uVwdRULYWJ0dRPvb4A4Tjm8Vlcb0iYYWbAAlg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782570"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/72782570/Aggressive_angiomyxoma_of_the_vagina_a_case_report_and_review_of_the_literature"><img alt="Research paper thumbnail of Aggressive angiomyxoma of the vagina: a case report and review of the literature" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/72782570/Aggressive_angiomyxoma_of_the_vagina_a_case_report_and_review_of_the_literature">Aggressive angiomyxoma of the vagina: a case report and review of the literature</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aggressive angiomyxomas are rare soft tissue tumours. They are mainly found females. Steeper and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aggressive angiomyxomas are rare soft tissue tumours. They are mainly found females. Steeper and Rosai described these tumors for the first time in 1983. The diagnosis and the treatment are difficult. The recurrence is frequent. The authors report a case of aggressive angiomyxoma of the vagina and the pelvis, diagnosed in a 34-old-woman. They discuss clinical symptoms and different signs allowing the diagnosis. Therapeutic management is also discussed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782570"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782570"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782570; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782570]").text(description); $(".js-view-count[data-work-id=72782570]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782570; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782570']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72782570]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782570,"title":"Aggressive angiomyxoma of the vagina: a case report and review of the literature","internal_url":"https://www.academia.edu/72782570/Aggressive_angiomyxoma_of_the_vagina_a_case_report_and_review_of_the_literature","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782561/Apolipoprotein_A_I_modulates_processes_associated_with_diet_induced_nonalcoholic_fatty_liver_disease_in_mice"><img alt="Research paper thumbnail of Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/81573030/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782561/Apolipoprotein_A_I_modulates_processes_associated_with_diet_induced_nonalcoholic_fatty_liver_disease_in_mice">Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice</a></div><div class="wp-workCard_item"><span>Molecular Medicine</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein (HDL). We investigate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein (HDL). We investigated the involvement of apoA-I in diet-induced accumulation of triglycerides in hepatocytes and its potential role in the treatment of nonalcoholic fatty liver disease (NAFLD). ApoA-I-deficient (apoA-I-/-) mice showed increased diet-induced hepatic triglyceride deposition and disturbed hepatic histology while they exhibited reduced glucose tolerance and insulin sensitivity. Quantification of FASN (fatty acid synthase 1), DGAT-1 (diacylglycerol O-acyltransferase 1), and PPARγ (peroxisome proliferator-activated receptor γ) mRNA expression suggested that the increased hepatic triglyceride content of the apoA-I-/mice was not due to de novo synthesis of triglycerides. Similarly, metabolic profiling did not reveal differences in the energy expenditure between the two mouse groups. However, apoA-I-/mice exhibited enhanced intestinal absorption of dietary triglycerides (3.6 ± 0.5 mg/dL/min for apoA-I-/versus 2.0 ± 0.7 mg/dL/min for C57BL/6 mice, P < 0.05), accelerated clearance of postprandial triglycerides and a reduced rate of hepatic very low density lipoprotein (VLDL) triglyceride secretion (9.8 ± 1.1 mg/dL/min for apoA-I-/versus 12.5 ± 1.3 mg/dL/min for C57BL/6 mice, P < 0.05). In agreement with these findings, adenovirus-mediated gene transfer of apoA-I Milano in apoA-I-/mice fed a Western-type diet for 12 wks resulted in a significant reduction in hepatic triglyceride content and an improvement of hepatic histology and architecture. Our data extend the current knowledge on the functions of apoA-I, indicating that in addition to its wellestablished properties in atheroprotection, it is also an important modulator of processes associated with diet-induced hepatic lipid deposition and NAFLD development in mice. Our findings raise the interesting possibility that expression of therapeutic forms of apoA-I by gene therapy approaches may have a beneficial effect on NAFLD.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9ac21ccaada269144127514bfdde71b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573030,"asset_id":72782561,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573030/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782561; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782561]").text(description); $(".js-view-count[data-work-id=72782561]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782561; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782561']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e9ac21ccaada269144127514bfdde71b" } } $('.js-work-strip[data-work-id=72782561]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782561,"title":"Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice","internal_url":"https://www.academia.edu/72782561/Apolipoprotein_A_I_modulates_processes_associated_with_diet_induced_nonalcoholic_fatty_liver_disease_in_mice","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573030,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573030/thumbnails/1.jpg","file_name":"molmed.2012.00113.pdf","download_url":"https://www.academia.edu/attachments/81573030/download_file","bulk_download_file_name":"Apolipoprotein_A_I_modulates_processes_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573030/molmed.2012.00113-libre.pdf?1646226195=\u0026response-content-disposition=attachment%3B+filename%3DApolipoprotein_A_I_modulates_processes_a.pdf\u0026Expires=1740429569\u0026Signature=KHbtFP0yFnsQs5FPFyucDceSkpz2RFdbi8kXPpElii9m5KAn39uk50kXuxC2uceWBdFw46PsaWargEZZFmqKMjh3KZq6fHtY-C1Vy~EOWGpUcE7KcQeQyYVgZfZbcSt1XxBwZUj8Zdq5vEn4zxI0aen1snlJZZsJxKHHD2QQJJggwT1-kby3M3NkWXzSoLbLF5ai-71ysT8Rs9qabferv2COI-fOmr7CvPT7d7yMs20i5-2QH9I0kPU27HboWn~9jgam9N2xF2FP0JCv0imYmJTjEzMp~50hygAjucrxKrgqzV~S65-JkO-sMq4NRHQDfTdN6ny5CY6MBIIvKv0m4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782551"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/72782551/Chronic_Alcohol_Consumption_Is_a_Major_Risk_Factor_for_Pancreatic_Necrosis_in_Acute_Pancreatitis"><img alt="Research paper thumbnail of Chronic Alcohol Consumption Is a Major Risk Factor for Pancreatic Necrosis in Acute Pancreatitis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/72782551/Chronic_Alcohol_Consumption_Is_a_Major_Risk_Factor_for_Pancreatic_Necrosis_in_Acute_Pancreatitis">Chronic Alcohol Consumption Is a Major Risk Factor for Pancreatic Necrosis in Acute Pancreatitis</a></div><div class="wp-workCard_item"><span>American Journal of Gastroenterology - AMER J GASTROENTEROL</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND:Much of the late morbidity and mortality of acute pancreatitis (AP) is attributed to c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND:Much of the late morbidity and mortality of acute pancreatitis (AP) is attributed to complications of pancreatic necrosis (PNEC). Early diagnosis of PNEC in high-risk patients is critical to management. Hemoconcentration is one risk factor for PNEC, but additional risk factors are likely implicated.AIMS:(1) To evaluate a series of preselected clinical factors in a prospectively collected cohort with AP to identify risk factors for PNEC and (2) to verify the relative risk of any newly identified factor(s) by retrospective analysis of a large patient cohort.METHODS:Phase I: 102 AP patients were prospectively ascertained, of which 77 (mean age 49 yr; 35 women, 42 men) underwent contrast-enhanced computerized tomography (CECT) and were studied. Eleven subjects developed PNEC (14%). Binary logistic regression was performed to identify any clinical factors associated with PNEC. Phase II: 1,474 anonymized patients admitted to the hospital with a diagnosis of AP were electronical...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782551"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782551"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782551; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782551]").text(description); $(".js-view-count[data-work-id=72782551]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782551; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782551']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72782551]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782551,"title":"Chronic Alcohol Consumption Is a Major Risk Factor for Pancreatic Necrosis in Acute Pancreatitis","internal_url":"https://www.academia.edu/72782551/Chronic_Alcohol_Consumption_Is_a_Major_Risk_Factor_for_Pancreatic_Necrosis_in_Acute_Pancreatitis","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782543"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/72782543/Biomechanical_and_structural_changes_following_the_decellularization_of_bovine_pericardial_tissues_for_use_as_a_tissue_engineering_scaffold"><img alt="Research paper thumbnail of Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/72782543/Biomechanical_and_structural_changes_following_the_decellularization_of_bovine_pericardial_tissues_for_use_as_a_tissue_engineering_scaffold">Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold</a></div><div class="wp-workCard_item"><span>Journal of Materials Science: Materials in Medicine</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To achieve natural scaffolds for tissue engineering applications we decellularized bovine pericar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To achieve natural scaffolds for tissue engineering applications we decellularized bovine pericardial (BP) tissues according to two different protocols: a novel treatment based on Triton(®) X-100 (12 h, 4 °C) (BP1) and a trypsin/EDTA treatment (37 °C, 48 h) (BP2). Results were compared with commercially available acellular xenogeneic biomaterials, Veritas(®) and Collamed(®). Biomechanical characteristics, high (E(h)) and low (E(l)) modulus of elasticity, of the fresh untreated tissue varied with the anatomical direction (apex to base (T) to transverse (L)) (mean ± SDEV): (41.63 ± 14.65-48.12 ± 10.19 MPa and 0.27 ± 0.05-0.30 ± 0.12 MPa respectively). BP1 had no mechanical effect (44.65 ± 19.73-52.67 ± 7.59 MPa and 0.37 ± 0.14-0.37 ± 0.11 MPa, respectively) but BP2 resulted in significant decrease in E(h) and E(l) (20.96 ± 8.17-36.82 ± 3.23 MPa and 0.20 ± 0.06-0.23 ± 0.06 MPa). Hysteresis ratio (h) varied (19-26 % of the loading energy) independently of anatomical direction. Glycosaminoglycans content was unaffected by BP1, while 22 % of chondroitin/dermatan sulphate and 60 % of hyaluronan were removed after BP2 treatment. Endothelial cell adhesion was achieved after 24 h and 3 days cell culture.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782543"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782543"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782543; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782543]").text(description); $(".js-view-count[data-work-id=72782543]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782543; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782543']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72782543]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782543,"title":"Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold","internal_url":"https://www.academia.edu/72782543/Biomechanical_and_structural_changes_following_the_decellularization_of_bovine_pericardial_tissues_for_use_as_a_tissue_engineering_scaffold","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782533"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782533/The_MAPK_AP_1_Runx2_signalling_axes_are_implicated_in_chondrosarcoma_pathobiology_either_independently_or_via_up_regulation_of_VEGF"><img alt="Research paper thumbnail of The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF" class="work-thumbnail" src="https://attachments.academia-assets.com/81572952/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782533/The_MAPK_AP_1_Runx2_signalling_axes_are_implicated_in_chondrosarcoma_pathobiology_either_independently_or_via_up_regulation_of_VEGF">The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF</a></div><div class="wp-workCard_item"><span>Histopathology</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either indepen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF Aims: To investigate whether and how the JNK ⁄ ERK-AP-1 ⁄-Runx2 signalling pathways and vascular endothelial growth factor (VEGF) are engaged in the pathogenesis of cartilaginous tumours. Chondrosarcoma is the third most common primary skeletal malignancy. Nevertheless, the molecular events underlying its pathogenesis remain elusive. JNK ⁄ ERK MAPKs and their downstream effectors, c-Jun and c-Fos (AP-1), are involved in chondroblastic differention ⁄ proliferation. These proteins interact with the Runx2 transcription factor, which is also implicated in chondroblast biology. VEGF, a key angiogenic factor, is up-regulated in human chondrosarcomas. Methods and results: Normal cartilage and neoplastic cells from 45 chondrosarcomas and 21 enchondromas were investigated immunohistochemically. We evaluated the cellular levels of JNK2, p-JNK2 (phosphorylated ⁄ activated JNK2), its main substrate, c-Jun, pc-Jun (phosphorylated ⁄ activated c-Jun) and c-Fos. Moreover, the levels of pERK (phosphorylated ⁄ activated ERK), Runx2 and VEGF were assessed. Positive immunostaining for all proteins was observed in the majority of the examined chondrosarcomas and in a small fraction of enchondromas. The expression levels of all proteins were positively and significantly correlated with each other. These levels were substantially augmented in high-grade compared with lowgrade chondrosarcomas and in low-grade tumours compared with benign enchondromas, implying a potential use as molecular markers for prediction of high-grade neoplasms. Conclusions: The JNK ⁄ ERK-AP-1 ⁄-Runx2 signal transduction 'network' is associated with chondroblastic malignant transformation and chondrosarcoma development, either separately or through coordinated induction of VEGF.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c5389977064fa671d6e19ecea9f3b86e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572952,"asset_id":72782533,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572952/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782533"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782533"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782533; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782533]").text(description); $(".js-view-count[data-work-id=72782533]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782533; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782533']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c5389977064fa671d6e19ecea9f3b86e" } } $('.js-work-strip[data-work-id=72782533]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782533,"title":"The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF","internal_url":"https://www.academia.edu/72782533/The_MAPK_AP_1_Runx2_signalling_axes_are_implicated_in_chondrosarcoma_pathobiology_either_independently_or_via_up_regulation_of_VEGF","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572952,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572952/thumbnails/1.jpg","file_name":"j.1365-2559.2005.02266.x20220302-956-kkju09.pdf","download_url":"https://www.academia.edu/attachments/81572952/download_file","bulk_download_file_name":"The_MAPK_AP_1_Runx2_signalling_axes_are.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572952/j.1365-2559.2005.02266.x20220302-956-kkju09-libre.pdf?1646226217=\u0026response-content-disposition=attachment%3B+filename%3DThe_MAPK_AP_1_Runx2_signalling_axes_are.pdf\u0026Expires=1740429569\u0026Signature=HGhDElaO2i-wtbaEOyzdLwMQ4AS4AD6wIRgb8SmtAHXa31l6XgVB7KYtdcn5SLvlNPBZKspSiZ-4DoRjlfIoPn8G0jerT0vbNb7lZHLDC1HVn3ACFq6NNsZAIxjQS0Rjw45Yw7ceJ8CZZaWPww4CFOjC7Qx-s9k8DifYV~gZmAdXWvD-f0N5HUdez5lWX0pr2NGEsRUQ-lm9myT1lM8b5~TjRced5xP~RIEA80Cu78cRju~QcCytQwIRh83gUWNLJS-14Mu7ZlBSjzX0aB340tP2nlSQo9xJ2qHKdnM1TeFFMxA8nOA9ATmftmYo5mhu0y5V4TLNL4df~LSt6k5p4g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782526"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782526/Systemic_silicosis_that_involves_the_pancreas"><img alt="Research paper thumbnail of Systemic silicosis that involves the pancreas" class="work-thumbnail" src="https://attachments.academia-assets.com/81572951/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782526/Systemic_silicosis_that_involves_the_pancreas">Systemic silicosis that involves the pancreas</a></div><div class="wp-workCard_item"><span>Gastrointestinal …</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="103067bd2f63c0f1a14da88759affa6a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572951,"asset_id":72782526,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572951/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782526"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782526"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782526; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782526]").text(description); $(".js-view-count[data-work-id=72782526]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782526; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782526']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "103067bd2f63c0f1a14da88759affa6a" } } $('.js-work-strip[data-work-id=72782526]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782526,"title":"Systemic silicosis that involves the pancreas","internal_url":"https://www.academia.edu/72782526/Systemic_silicosis_that_involves_the_pancreas","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572951,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572951/thumbnails/1.jpg","file_name":"j.gie.2005.07.01020220302-20746-151cggj.pdf","download_url":"https://www.academia.edu/attachments/81572951/download_file","bulk_download_file_name":"Systemic_silicosis_that_involves_the_pan.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572951/j.gie.2005.07.01020220302-20746-151cggj-libre.pdf?1646226217=\u0026response-content-disposition=attachment%3B+filename%3DSystemic_silicosis_that_involves_the_pan.pdf\u0026Expires=1740485756\u0026Signature=HME1avCzFrC7Z0TdMlgY772FQBu10Skl5rn7QH7MUTpbG-Y8yYI3SO41VTOqWWNmQY0oMEKNz9vqCSyBU4cM17DDhao-~6EflfCcThDCq-RknQ6fXHe3oXvVfrBIq2bNqZdxK6VDkGYPUjyrC6M9zEEBPSbAJCfQhtBoWGB3cTK-HxM4blGRjjB9eeBvUfnoxILYGb7Hak-hEhOzbOzm1Yq-1SutmZHi86gP964qBZNLHP5-pr~-dHuOjSkfKUwMtyiKvdthxkX8Nzty8dORtShCNTJZtDzkcZhDRGQu-cqJWf0dCwpkx4mqTZc80JcTP0AYnXNdwEWIaF7JGHeIEg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3155970" id="papers"><div class="js-work-strip profile--work_container" data-work-id="72782692"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782692/Collagen_orientation_probed_by_polarized_Raman_spectra_can_serve_as_differential_diagnosis_indicator_between_different_grades_of_meniscus_degeneration"><img alt="Research paper thumbnail of Collagen orientation probed by polarized Raman spectra can serve as differential diagnosis indicator between different grades of meniscus degeneration" class="work-thumbnail" src="https://attachments.academia-assets.com/81572940/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782692/Collagen_orientation_probed_by_polarized_Raman_spectra_can_serve_as_differential_diagnosis_indicator_between_different_grades_of_meniscus_degeneration">Collagen orientation probed by polarized Raman spectra can serve as differential diagnosis indicator between different grades of meniscus degeneration</a></div><div class="wp-workCard_item"><span>Scientific Reports</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of the present study was to analyze normal and degenerated menisci with Raman methodo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of the present study was to analyze normal and degenerated menisci with Raman methodology on thin sections of formalin fixed paraffin embedding tissues and to correlate the Raman findings with the grade of meniscus degeneration. Menisci (n = 27) were removed from human knee joints after total knee replacement or meniscectomy. Following routine histopathological analysis to determine the grade of meniscal lesions obtained from healthy and degenerated formaline fixed paraffin embedded (FFPE) meniscal sections, Raman polarization approach was applied to evaluate the orientation of collagen fibrils in different levels of the same 5 μm thick FFPE meniscal tissue sections, used for histopathological assessment. We collected Raman spectra in two different polarization geometries, v-HH and v-VV, and calculated the mean value of the v-HH/v-VV intensity ratio of two Raman bands, sensitive and non-sensitive to the molecular orientation. The collagen specific amide I band at 1665 cm...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0d41b54097ae57a68a3110d8430f56e5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572940,"asset_id":72782692,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572940/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782692"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782692"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782692; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782692]").text(description); $(".js-view-count[data-work-id=72782692]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782692; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782692']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0d41b54097ae57a68a3110d8430f56e5" } } $('.js-work-strip[data-work-id=72782692]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782692,"title":"Collagen orientation probed by polarized Raman spectra can serve as differential diagnosis indicator between different grades of meniscus degeneration","internal_url":"https://www.academia.edu/72782692/Collagen_orientation_probed_by_polarized_Raman_spectra_can_serve_as_differential_diagnosis_indicator_between_different_grades_of_meniscus_degeneration","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572940,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572940/thumbnails/1.jpg","file_name":"s41598-021-99569-2.pdf","download_url":"https://www.academia.edu/attachments/81572940/download_file","bulk_download_file_name":"Collagen_orientation_probed_by_polarized.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572940/s41598-021-99569-2-libre.pdf?1646226221=\u0026response-content-disposition=attachment%3B+filename%3DCollagen_orientation_probed_by_polarized.pdf\u0026Expires=1740429569\u0026Signature=CRfazlWt4BLCQd-h2mrY39jDxe7Ke~Eqh4DlJXAeBIfOsslmRh~BAVERVdZ8VqnOXaLyJlZG93Uik0AB8H1d6hFIzANTjsCukXR7dakSdF2Gdi6TeZv~-fBw4X3o7VmijHkV0UGPMQZvu6DiTpRfnJbX09Scj2cVZnWTXTsuroxMzkYvdOpRsMoJKgkC7LpkxaP98SY0VFjEYBvTzlzo7RlWfvLXbWo6wnnQKmoUIzKUFjHVHe7kEsGcJTpGtJyLP7BGTTS0StecNk1zvqprCdzuGX93l5KYbx-eyfU1nGrHY~YaFdcQtZr-nJ0DojbJxlwCSd5y6ghN1-qmNmUokg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":81572941,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572941/thumbnails/1.jpg","file_name":"s41598-021-99569-2.pdf","download_url":"https://www.academia.edu/attachments/81572941/download_file","bulk_download_file_name":"Collagen_orientation_probed_by_polarized.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572941/s41598-021-99569-2-libre.pdf?1646226221=\u0026response-content-disposition=attachment%3B+filename%3DCollagen_orientation_probed_by_polarized.pdf\u0026Expires=1740429569\u0026Signature=ZE18cJDEvxMzMoW1lixXE7b2SxCPnOMEK0B-NLyK9I00tnPV4P6RrEVZp6odzKirP~6J19GHrXICkJmak8AX5oW9Ws3B8ktaJG4e4Yc6NVqcVU~Kiqimync9dEWg2Tj1HQ4elK6zY2D8jLM2qHz-iOKj5Lw4ZAneBnqjCgqHtHCbazx~i0gjqHtcsoF9hGIthfo7s6dArY3a~jfdwyJ9zp5dj3-zrPzKDGtp7XgDLd2z8qbUsDtohULwS5SnVfN~3NtVI2n~0Zovz528Y8NCue09N9lyGOfDjcw-9tO9kLrYvHG9qv4r-VZL4xp5R5mbCnPi1c5TGjoxKoqN-mXDjg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782683"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782683/Platelet_rich_Plasma_and_Mesenchymal_Stem_Cells_Local_Infiltration_Promote_Functional_Recovery_and_Histological_Repair_of_Experimentally_Transected_Sciatic_Nerves_in_Rats"><img alt="Research paper thumbnail of Platelet-rich Plasma and Mesenchymal Stem Cells Local Infiltration Promote Functional Recovery and Histological Repair of Experimentally Transected Sciatic Nerves in Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/81573061/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782683/Platelet_rich_Plasma_and_Mesenchymal_Stem_Cells_Local_Infiltration_Promote_Functional_Recovery_and_Histological_Repair_of_Experimentally_Transected_Sciatic_Nerves_in_Rats">Platelet-rich Plasma and Mesenchymal Stem Cells Local Infiltration Promote Functional Recovery and Histological Repair of Experimentally Transected Sciatic Nerves in Rats</a></div><div class="wp-workCard_item"><span>Cureus</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The number of counted neural axons at the area distal to the nerve repair site were significantly...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The number of counted neural axons at the area distal to the nerve repair site were significantly repetitive (p<0.05) in both the PRP and MSC groups when compared with the control group. Conclusions Both PRP and MSCs appear to play an essential role in the enhancement of nerve repair in terms of functionality and histology. MSCs group demonstrated a positive effect, whereas the PRP group showed statistically significant better results.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e4afccad900dc669a5784b93e587e931" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573061,"asset_id":72782683,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573061/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782683"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782683"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782683; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782683]").text(description); $(".js-view-count[data-work-id=72782683]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782683; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782683']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e4afccad900dc669a5784b93e587e931" } } $('.js-work-strip[data-work-id=72782683]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782683,"title":"Platelet-rich Plasma and Mesenchymal Stem Cells Local Infiltration Promote Functional Recovery and Histological Repair of Experimentally Transected Sciatic Nerves in Rats","internal_url":"https://www.academia.edu/72782683/Platelet_rich_Plasma_and_Mesenchymal_Stem_Cells_Local_Infiltration_Promote_Functional_Recovery_and_Histological_Repair_of_Experimentally_Transected_Sciatic_Nerves_in_Rats","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573061,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573061/thumbnails/1.jpg","file_name":"1590337648-20200524-31511-e7j54d.pdf","download_url":"https://www.academia.edu/attachments/81573061/download_file","bulk_download_file_name":"Platelet_rich_Plasma_and_Mesenchymal_Ste.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573061/1590337648-20200524-31511-e7j54d-libre.pdf?1646226189=\u0026response-content-disposition=attachment%3B+filename%3DPlatelet_rich_Plasma_and_Mesenchymal_Ste.pdf\u0026Expires=1740485755\u0026Signature=YTHyjBeRf2pvQzHqmA7csZH3dycZeOyjjExrmkbNofPWFmrZWqmLG~bKCMb8ElDTtfA-SFNGUfvGmS07MmgVxwfVfMv3AybGkfUKTx2n4HGtBiOOP5t4y1DMQosinJKMlwgTGrz6PFkSvwPP-6wG6j17ruqWSQjrmwSsRKhBt0wx1zQIYw-RZ2QY0-uKd5XoiKkl6eMqu8Il4SxBt~rQoUqZExKh8dGYVL~WYKHRgdZ5~hhXbuw~uToZGxpMYwqhfEKtVF9SA-B9IN7lH1maoyWgExy5DGEHGAZzJYIcJ5XYVaxyS8qZ3r2zjou9djfbyRYUb2tSybRcu3vYD7UO8w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782674"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782674/Biglycan_Regulates_MG63_Osteosarcoma_Cell_Growth_Through_a_LPR6_%CE%B2_Catenin_IGFR_IR_Signaling_Axis"><img alt="Research paper thumbnail of Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis" class="work-thumbnail" src="https://attachments.academia-assets.com/81573050/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782674/Biglycan_Regulates_MG63_Osteosarcoma_Cell_Growth_Through_a_LPR6_%CE%B2_Catenin_IGFR_IR_Signaling_Axis">Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis</a></div><div class="wp-workCard_item"><span>Frontiers in oncology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone homeostas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone homeostasis and development as well as in bone pathology. In the present study biglycan was identified as a positive regulator of MG63 osteosarcoma cell growth ( ≤ 0.001). IGF-I was shown to increase biglycan expression ( ≤ 0.01), whereas biglycan-deficiency attenuated significantly both basal and IGF-I induced cell proliferation of MG63 cells ≤ 0.001; ≤ 0.01, respectively). These effects were executed through the IGF-IR receptor whose activation was strongly attenuated ( ≤ 0.01) in biglycan-deficient MG63 cells. Biglycan, previously shown to regulate Wnt/β-catenin pathway, was demonstrated to induce a significant increase in β-catenin protein expression evident at cytoplasmic ( ≤ 0.01), membrane ( ≤ 0.01), and nucleus fractions in MG63 cells ( ≤ 0.05). As demonstrated by immunofluorescence, increase in β-catenin expression is attributed to co-localization of biglycan with the Wnt co-receptor low...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a9229d18a6afdaac31ebd3e02c376d54" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573050,"asset_id":72782674,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573050/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782674"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782674"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782674; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782674]").text(description); $(".js-view-count[data-work-id=72782674]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782674; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782674']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a9229d18a6afdaac31ebd3e02c376d54" } } $('.js-work-strip[data-work-id=72782674]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782674,"title":"Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis","internal_url":"https://www.academia.edu/72782674/Biglycan_Regulates_MG63_Osteosarcoma_Cell_Growth_Through_a_LPR6_%CE%B2_Catenin_IGFR_IR_Signaling_Axis","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573050,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573050/thumbnails/1.jpg","file_name":"11fdecf7a3eb292ef1b3afe97296039b76d1.pdf","download_url":"https://www.academia.edu/attachments/81573050/download_file","bulk_download_file_name":"Biglycan_Regulates_MG63_Osteosarcoma_Cel.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573050/11fdecf7a3eb292ef1b3afe97296039b76d1-libre.pdf?1646226191=\u0026response-content-disposition=attachment%3B+filename%3DBiglycan_Regulates_MG63_Osteosarcoma_Cel.pdf\u0026Expires=1740485755\u0026Signature=Sm~ZNyYicLorFp4vPQs29yjGeNvEu8YwZOsPxlWd~QdcuyOhROuq5ZJh40gtwVz~9V6umJYi~TwGhlPv4tHYTl75qic4Z-K7JJY~cqcLla8Zi-f0zmpe8CCB11u1rjfcduaQn4eWnuxZMPfif~GDgb-jGKfeb0MeLl~lkoxYX5J8f1uabJy2LnNn~ZHsDOYHU4qQ~vsFdBNDuLULeI1jKyXeycjXZwiwJGALURUZSA8bja0Sx-FlaWtLzVMl6jnzlYh95rGXc3iat2xg7KvmFWpXOv7ZRxYp0849s5eoeJbyt28V~QO1CDgZT9YSCDrsL2z3xGMl5LjEXhlbp-4~SQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782664"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782664/Western_type_diet_differentially_modulates_osteoblast_osteoclast_and_lipoblast_differentiation_and_activation_in_a_background_of_APOE_deficiency"><img alt="Research paper thumbnail of Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency" class="work-thumbnail" src="https://attachments.academia-assets.com/81573060/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782664/Western_type_diet_differentially_modulates_osteoblast_osteoclast_and_lipoblast_differentiation_and_activation_in_a_background_of_APOE_deficiency">Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency</a></div><div class="wp-workCard_item"><span>Laboratory investigation; a journal of technical methods and pathology</span><span>, Jan 11, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During the past few years, considerable evidence has uncovered a strong relationship between fat ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During the past few years, considerable evidence has uncovered a strong relationship between fat and bone metabolism. Consequently, alterations in plasma lipid metabolic pathways strongly affect bone mass and quality. We recently showed that the deficiency of apolipoprotein A-1 (APOA1), a central regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, results in reduced bone mass in C57BL/6 mice. It is documented that apolipoprotein E (APOE), a lipoprotein know for its atheroprotective functions and de novo biogenesis of HDL-C, is associated with the accumulation of fat in the liver and other organs and regulates bone mass in mice. We further studied the mechanism of APOE in bone metabolism using well-characterized APOE knockout mice. We found that bone mass was remarkably reduced in APOE deficient mice fed Western-type diet (WTD) compared to wild type counterparts. Static (microCT-based) and dynamic histomorphometry showed that the reduced bone mass in APOΕ mice is at...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a2a6bb24ef32dd62d18e242e2d2f6f8e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573060,"asset_id":72782664,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573060/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782664"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782664"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782664; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782664]").text(description); $(".js-view-count[data-work-id=72782664]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782664; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782664']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a2a6bb24ef32dd62d18e242e2d2f6f8e" } } $('.js-work-strip[data-work-id=72782664]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782664,"title":"Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency","internal_url":"https://www.academia.edu/72782664/Western_type_diet_differentially_modulates_osteoblast_osteoclast_and_lipoblast_differentiation_and_activation_in_a_background_of_APOE_deficiency","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573060,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573060/thumbnails/1.jpg","file_name":"s41374-018-0107-7.pdf","download_url":"https://www.academia.edu/attachments/81573060/download_file","bulk_download_file_name":"Western_type_diet_differentially_modulat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573060/s41374-018-0107-7-libre.pdf?1646226187=\u0026response-content-disposition=attachment%3B+filename%3DWestern_type_diet_differentially_modulat.pdf\u0026Expires=1740485755\u0026Signature=afyiqJe-zsnKSNJV4X0xO0EWzZ7uRXwJ5eW-5y~lobTcnzTt3L3TupVHkCP9WppcB8s5R6sEJj9hZiwPIkkLEllQ0RKP5PvjIOsBTokiVISlwew~AvP8foGTV3Hcc8~Am9N41YZHuGAh7704TEMD8ZLT1y4PIuEGE~SWLdrPxzAiHZxRfHfR2OX0w7UTZTeEbBFQQ9FcbngWeiIxmDfp9W7BhCffB-Si3xmRTWUnAkAENvVw3HMw0hYfSk5W6mp3Sy6y0bkw7b-rUtVJp6u3S0ZgVN2b2u5EZbTTeLsNB0LNB~ybsZbdGJVmzgN9U1OT6nV5S-sLAtOqmNNu6BloTQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782657"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782657/IGF_I_regulates_HT1080_fibrosarcoma_cell_migration_through_a_syndecan_2_Erk_ezrin_signaling_axis"><img alt="Research paper thumbnail of IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis" class="work-thumbnail" src="https://attachments.academia-assets.com/81573035/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782657/IGF_I_regulates_HT1080_fibrosarcoma_cell_migration_through_a_syndecan_2_Erk_ezrin_signaling_axis">IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis</a></div><div class="wp-workCard_item"><span>Experimental cell research</span><span>, Dec 1, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fibrosarcoma is a tumor of mesenchymal origin, originating from fibroblasts. IGF-I is an anabolic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fibrosarcoma is a tumor of mesenchymal origin, originating from fibroblasts. IGF-I is an anabolic growth factor which exhibits significant involvement in cancer progression. In this study, we investigated the possible participation of syndecan-2 (SDC-2), a cell membrane heparan sulfate (HS) proteoglycan on IGF-I dependent fibrosarcoma cell motility. Our results demonstrate that SDC-2-deficient HT1080 cells exhibit attenuated IGF-I-dependent chemotactic migration (p &lt; 0.001). SDC-2 was found to co-localize to IGF-I receptor (IGF-IR) in a manner dependent on IGF-I activity (P ≤ 0.01). In parallel, the downregulation of SDC-2 significantly inhibited both basal and due to IGF-I action ERK1/2 activation, (p &lt; 0.001). The phosphorylation levels of ezrin (Thr567), which is suggested to act as a signaling bridge between the cellular membrane receptors and actin cytoskeleton, were strongly enhanced by IGF-I at both 1h and 24h (p &lt; 0.05; p &lt; 0.01). The formation of an immunoprecip...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5c39663c0dd0e5358a8785db6e8334ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573035,"asset_id":72782657,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573035/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782657"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782657"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782657; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782657]").text(description); $(".js-view-count[data-work-id=72782657]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782657; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782657']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5c39663c0dd0e5358a8785db6e8334ec" } } $('.js-work-strip[data-work-id=72782657]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782657,"title":"IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis","internal_url":"https://www.academia.edu/72782657/IGF_I_regulates_HT1080_fibrosarcoma_cell_migration_through_a_syndecan_2_Erk_ezrin_signaling_axis","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573035,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573035/thumbnails/1.jpg","file_name":"IGF-I_20regulates_20HT1080.pdf","download_url":"https://www.academia.edu/attachments/81573035/download_file","bulk_download_file_name":"IGF_I_regulates_HT1080_fibrosarcoma_cell.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573035/IGF-I_20regulates_20HT1080-libre.pdf?1646226194=\u0026response-content-disposition=attachment%3B+filename%3DIGF_I_regulates_HT1080_fibrosarcoma_cell.pdf\u0026Expires=1740485755\u0026Signature=ELmrYvc8Cxx7lmFT1AzNMOVq3Olqp06H-C0SBxBP-2~ofcMZWRYIUHDyiTTLQQSpm7AvBVVds9xO4UiFCAjuCbCLkzxicdrKCs5rPDvNB6wJStpNQQRIy~0xIJbclcil5t9vNYuND~~s4vxFGDyEdLoL5SHRG0zrDHy3v2lM4CJedASX2IviKPOarogjvN4i7962~oZZKSUnIPl2Qotllsmi5fi5QzLDeM~D28is2WcQo8nbmeeUGVoIPwoHxWrN6uHEkEQ8ow5~2QC4LuFJvgHBRw-~rXmERBLrubEWfSLbCB0spDOnjJMnOiZIGJoKpoB8AueR0zD9RdFDgOylCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782646"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782646/High_density_lipoprotein_HDL_metabolism_and_bone_mass"><img alt="Research paper thumbnail of High-density lipoprotein (HDL) metabolism and bone mass" class="work-thumbnail" src="https://attachments.academia-assets.com/81573044/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782646/High_density_lipoprotein_HDL_metabolism_and_bone_mass">High-density lipoprotein (HDL) metabolism and bone mass</a></div><div class="wp-workCard_item"><span>Journal of Endocrinology</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is well appreciated that high-density lipoprotein (HDL) and bone physiology and pathology are ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is well appreciated that high-density lipoprotein (HDL) and bone physiology and pathology are tightly linked. Studies, primarily in mouse models, have shown that dysfunctional and/or disturbed HDL can affect bone mass through many different ways. Specifically, reduced HDL levels have been associated with the development of an inflammatory microenvironment that affects the differentiation and function of osteoblasts. In addition, perturbation in metabolic pathways of HDL favors adipoblastic differentiation and restrains osteoblastic differentiation through, among others, the modification of specific bone-related chemokines and signaling cascades. Increased bone marrow adiposity also deteriorates bone osteoblastic function and thus bone synthesis, leading to reduced bone mass. In this review, we present the current knowledge and the future directions with regard to the HDL–bone mass connection. Unraveling the molecular phenomena that underline this connection will promote the deepe...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5a92f2501d3f17ade241659527b6e3a1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573044,"asset_id":72782646,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573044/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782646"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782646"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782646; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782646]").text(description); $(".js-view-count[data-work-id=72782646]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782646; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782646']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5a92f2501d3f17ade241659527b6e3a1" } } $('.js-work-strip[data-work-id=72782646]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782646,"title":"High-density lipoprotein (HDL) metabolism and bone mass","internal_url":"https://www.academia.edu/72782646/High_density_lipoprotein_HDL_metabolism_and_bone_mass","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573044,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573044/thumbnails/1.jpg","file_name":"a7e9fedd1e08c31995d5394e89099750e0bb.pdf","download_url":"https://www.academia.edu/attachments/81573044/download_file","bulk_download_file_name":"High_density_lipoprotein_HDL_metabolism.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573044/a7e9fedd1e08c31995d5394e89099750e0bb-libre.pdf?1646226191=\u0026response-content-disposition=attachment%3B+filename%3DHigh_density_lipoprotein_HDL_metabolism.pdf\u0026Expires=1740485755\u0026Signature=gun1jUUZYz2kZQnqtb6LJx8p8zHu9s0jQjfj9cwmRb15kqtlh9fLL60vFHdlSqLyk4jOoqgoaZDvRW0iQzjvLgPBvYxbNDUXAyHfC2pJI2xPnKPbyZRyMbcwQ8RQvEee4wQXntrkRRQ3bDhv-3phyVIglS6xzs-TAfXRErrlljcXZ9TO5lStsdWwWMu35Bfms~mTzcVPrvG4Me3dbaOoTXs06yI-3xlAmteJXdihFwK41F4M-r-GcKA6FIZwbZrW-9MpMiIn~BsafG2FywVagbzdp7I8HYupsBOMCN8g05wAe6e4InLy2MJziblzZjVn4rccUXDjwpJ~i2ugEOEMFg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782641"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782641/Novel_evidence_that_ApoA_1_deficiency_facilitates_HSC_mobilization_and_differentiation_and_halts_HSC_quiescence_and_self_renewal_in_mice"><img alt="Research paper thumbnail of Novel evidence that ApoA-1 deficiency facilitates HSC mobilization and differentiation and halts HSC quiescence and self-renewal in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/81573025/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782641/Novel_evidence_that_ApoA_1_deficiency_facilitates_HSC_mobilization_and_differentiation_and_halts_HSC_quiescence_and_self_renewal_in_mice">Novel evidence that ApoA-1 deficiency facilitates HSC mobilization and differentiation and halts HSC quiescence and self-renewal in mice</a></div><div class="wp-workCard_item"><span>Bone Abstracts</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The expression of CLCX12 was significantly reduced, while the expression CXCR4 was greatly augmen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The expression of CLCX12 was significantly reduced, while the expression CXCR4 was greatly augmented (possibly via feedback cell reactionmechanism) in the WBMCs of the ApoA-I-/compared to the WT mice. 2.WBMCs from ApoA-I-/mice displayed strongly increased mRNA levels of Jagged-1 compared to the WT mice. 3.Osteopontin mRNA expression levels were decreased in apoA-1-/mice in contrast to the WT mice. 4.Flow cytometry revealed no significant differences in CXCR4 expression on HSCs of both study groups. CONCLUSIONS: The present study suggests for the first time that ApoA-I deficiency (and thus impaired HDL) halts HSC maintenance and quiescence, whereas it promotes HSC differentiation suggesting that it may be involved in the pathobiology of hematologic malignancies and possibly bone metastases.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f614a6c30c4b32dc058c26229a6b6b1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573025,"asset_id":72782641,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573025/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782641"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782641"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782641; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782641]").text(description); $(".js-view-count[data-work-id=72782641]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782641; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782641']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f614a6c30c4b32dc058c26229a6b6b1" } } $('.js-work-strip[data-work-id=72782641]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782641,"title":"Novel evidence that ApoA-1 deficiency facilitates HSC mobilization and differentiation and halts HSC quiescence and self-renewal in mice","internal_url":"https://www.academia.edu/72782641/Novel_evidence_that_ApoA_1_deficiency_facilitates_HSC_mobilization_and_differentiation_and_halts_HSC_quiescence_and_self_renewal_in_mice","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573025,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573025/thumbnails/1.jpg","file_name":"7baf47528cbb6fb00f4d46364651e73a503b.pdf","download_url":"https://www.academia.edu/attachments/81573025/download_file","bulk_download_file_name":"Novel_evidence_that_ApoA_1_deficiency_fa.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573025/7baf47528cbb6fb00f4d46364651e73a503b-libre.pdf?1646226198=\u0026response-content-disposition=attachment%3B+filename%3DNovel_evidence_that_ApoA_1_deficiency_fa.pdf\u0026Expires=1740485755\u0026Signature=a5wYwoktVLuCqcqeSYA9r3Du~-8OBET22LXA6IKnToCVW26q1fj6wnFRhIrIBwvDVbRHPBI5hhDyfzBZhylIUD3OSb8P2sT5kJOIB9tk6DU3HG02nfufWRRnCI~p2gO~Cx5MO4ZcRM7rPt7q2fmYOj3oF76WIcVVZON5JTIl4acycgCPeh-RSievBDEdsQlxjK4FvXCsPdqB3MDsd2FhJEM-qdxSzvydPmC~x2txf7FRAoG~rkTk4ag84OEwHGCbW5RJiI4ZP5tDpSMJZhL9QGanXwO2kdHRMbwb~uHsSK7Ur~AS6L7bUOLodq4LMgRMe-PGiCMmqe0n65dKa36kEg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782634"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782634/Cancer_of_unknown_primary_ultimately_diagnosed_as_male_breast_cancer_A_rare_case_report"><img alt="Research paper thumbnail of Cancer of unknown primary ultimately diagnosed as male breast cancer: A rare case report" class="work-thumbnail" src="https://attachments.academia-assets.com/81573019/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782634/Cancer_of_unknown_primary_ultimately_diagnosed_as_male_breast_cancer_A_rare_case_report">Cancer of unknown primary ultimately diagnosed as male breast cancer: A rare case report</a></div><div class="wp-workCard_item"><span>Molecular and Clinical Oncology</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancers of unknown primary (CUP) constitute a significant diagnostic and therapeutic challenge fo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancers of unknown primary (CUP) constitute a significant diagnostic and therapeutic challenge for clinicians and a frequent cause of cancer-related mortality in Western countries. Immunohistochemistry assays are commonly used to identify the primary cancer, but fail in approximately one-third of cases. The identification of the possible origin of CUP is crucial, as it may help select the appropriate treatment options. We herein present the case of a 54-year-old male patient, who presented with lower back pain in June, 2013. Following a thorough investigation, the clinical and pathological findings could not identify the primary cancer, leading towards a misdiagnosis. Ultimately, microRNA testing of the resected spine lesion was able to identify the primary tumor as male breast cancer and allow for optimal treatment of the patient.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c7ba8d7318a172de984a9c8a71d4a6c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573019,"asset_id":72782634,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573019/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782634"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782634]").text(description); $(".js-view-count[data-work-id=72782634]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782634']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c7ba8d7318a172de984a9c8a71d4a6c5" } } $('.js-work-strip[data-work-id=72782634]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782634,"title":"Cancer of unknown primary ultimately diagnosed as male breast cancer: A rare case report","internal_url":"https://www.academia.edu/72782634/Cancer_of_unknown_primary_ultimately_diagnosed_as_male_breast_cancer_A_rare_case_report","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573019,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573019/thumbnails/1.jpg","file_name":"7749a7cba90bb38d4d2c50aa1b1f91b1f8cd.pdf","download_url":"https://www.academia.edu/attachments/81573019/download_file","bulk_download_file_name":"Cancer_of_unknown_primary_ultimately_dia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573019/7749a7cba90bb38d4d2c50aa1b1f91b1f8cd-libre.pdf?1646226198=\u0026response-content-disposition=attachment%3B+filename%3DCancer_of_unknown_primary_ultimately_dia.pdf\u0026Expires=1740485755\u0026Signature=Ish7HAp2pdK1n1pIQeftGWmS64webSGa6GLdEF28zAw0QAxCTN-dD9kr20k4GaL~6W8gsnsTRI2NV1dL7~TIYCOuAAcvzLeoTm1vW5C4qUtS1QkgYq2eKPPYCTzdSxeGl34eBWddLnrv6Sh43w3VPfX5wXDsxm5UjFEaYRhtyYjBF0RuaEOPmX5eunFqlxKdduJAg2pQ9KvZI~9vaLDz4eUbTm14a6Q58oOnrf~HqfEjj4LUHYb4C4UxgUz5xIBpMNLGCUoIG8H~Q0-TE62LYHXk69ryO5XsElEYprWlidujmLrvFKdnQHawyKejqfgSpvcjnHkHG32iFacRa~v3rw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782621"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782621/B_cell_depletion_therapy_upregulates_Dkk_1_skin_expression_in_patients_with_systemic_sclerosis_association_with_enhanced_resolution_of_skin_fibrosis"><img alt="Research paper thumbnail of B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis" class="work-thumbnail" src="https://attachments.academia-assets.com/81573026/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782621/B_cell_depletion_therapy_upregulates_Dkk_1_skin_expression_in_patients_with_systemic_sclerosis_association_with_enhanced_resolution_of_skin_fibrosis">B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis</a></div><div class="wp-workCard_item"><span>Arthritis research & therapy</span><span>, Jan 21, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Rituximab (RTX) may favorably affect skin and lung fibrosis in patients with systemic sclerosis (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Rituximab (RTX) may favorably affect skin and lung fibrosis in patients with systemic sclerosis (SSc); however, the underlying molecular mechanisms remain unknown. We aimed to explore the hypothesis that RTX may mediate its antifibrotic effects by regulating the expression of Dickkopf-1 (Dkk-1), an inhibitor of the Wnt pathway. Fourteen patients with SSc and five healthy subjects were recruited. Dkk-1 expression was immunohistochemically assessed in skin biopsies obtained from 11 patients with SSc (8 treated with RTX and 3 with standard treatment), whereas DKK1 gene expression was assessed in 3 patients prior to and following RTX administration. In baseline biopsies obtained from all patients with SSc but not in healthy subjects, Dkk-1 was undetectable in skin fibroblasts. Following RTX treatment, four out of eight patients had obvious upregulation of Dkk-1 skin expression. Similarly, RTX treatment correlated with a significant 4.8-fold upregulation of DKK1 gene expression (p = 0.03...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="12a76c863946672ca8ea7d7351546284" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573026,"asset_id":72782621,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573026/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782621"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782621"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782621; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782621]").text(description); $(".js-view-count[data-work-id=72782621]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782621; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782621']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "12a76c863946672ca8ea7d7351546284" } } $('.js-work-strip[data-work-id=72782621]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782621,"title":"B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis","internal_url":"https://www.academia.edu/72782621/B_cell_depletion_therapy_upregulates_Dkk_1_skin_expression_in_patients_with_systemic_sclerosis_association_with_enhanced_resolution_of_skin_fibrosis","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573026,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573026/thumbnails/1.jpg","file_name":"pmc4875588.pdf","download_url":"https://www.academia.edu/attachments/81573026/download_file","bulk_download_file_name":"B_cell_depletion_therapy_upregulates_Dkk.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573026/pmc4875588-libre.pdf?1646226196=\u0026response-content-disposition=attachment%3B+filename%3DB_cell_depletion_therapy_upregulates_Dkk.pdf\u0026Expires=1740485755\u0026Signature=a7emp5sQ0EBZm5x0WM2sxTxx2xBXj9MkY1v8pT-AlzV4xKif3rWLpbZoNkCB7f6q0qG~1kz6hEf6tKaciLXyPbiBAlqynnZCW0RIR0p3Lo5MMnN8LtNz-PcxCGxct00wwSj82HpSTblonPwzUVwoAzbcHKwgtyZLptMbcffYSBTu8r2qRtqsyQ7cniyQmGmap2cMxzsOAd-Iz8K6oB~f1wqLk55pmBhfWXpwkb~VEd9Em5acYTbCAC8YncGLKO6tkVLj27Gun4sCjvNkOZ4bAnloCSkvZNqg5e9EVZ8ehXLIheeTGNwNPLGJm3RQMqs1yeCJF5bNYhAkHCTQS08oxA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782615"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782615/Giant_Cell_Tumor_of_the_Patella_Tendon_Sheath_Presenting_as_a_Painful_Locked_Knee"><img alt="Research paper thumbnail of Giant Cell Tumor of the Patella Tendon Sheath Presenting as a Painful Locked Knee" class="work-thumbnail" src="https://attachments.academia-assets.com/81573003/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782615/Giant_Cell_Tumor_of_the_Patella_Tendon_Sheath_Presenting_as_a_Painful_Locked_Knee">Giant Cell Tumor of the Patella Tendon Sheath Presenting as a Painful Locked Knee</a></div><div class="wp-workCard_item"><span>American Journal of Case Reports</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: Rare disease Background: The giant cell tumor of the tendon sheath (GCT-TS) is a benig...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: Rare disease Background: The giant cell tumor of the tendon sheath (GCT-TS) is a benign proliferative synovial tumor manifesting as an intra-articular solitary nodule. When it involves the infrapatellar fat pad it can present acutely as a painful locked knee. Case Report: A 26-year-old white male presented with a 2-week history of painful locking in his right knee. Clinical examination revealed lack of extension by approximately 20°. To help establish the diagnosis, an MRI scan of the right knee was performed, showing a large (5×4×2 cm), oval, well-circumscribed mass with a low-intensity homogenous signal. The size of the mass prohibited the removal by arthroscopy and we therefore proceeded with an open arthrotomy. Histological examination showed a tendosynovial giant cell tumor of the patella tendon sheath. At the latest follow-up, 2 years postoperatively, there was no local tumor recurrence. Conclusions: These rare tumorous lesions should be included in the differential diagnosis of painful locking knee, especially in the absence of definite traumatic history.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4efce2a9ce6fa660c1f005146b8d0ea5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573003,"asset_id":72782615,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573003/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782615"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782615"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782615; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782615]").text(description); $(".js-view-count[data-work-id=72782615]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782615; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782615']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4efce2a9ce6fa660c1f005146b8d0ea5" } } $('.js-work-strip[data-work-id=72782615]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782615,"title":"Giant Cell Tumor of the Patella Tendon Sheath Presenting as a Painful Locked Knee","internal_url":"https://www.academia.edu/72782615/Giant_Cell_Tumor_of_the_Patella_Tendon_Sheath_Presenting_as_a_Painful_Locked_Knee","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573003,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573003/thumbnails/1.jpg","file_name":"b7da8bbd4276b6ab74625663cea1558423bb.pdf","download_url":"https://www.academia.edu/attachments/81573003/download_file","bulk_download_file_name":"Giant_Cell_Tumor_of_the_Patella_Tendon_S.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573003/b7da8bbd4276b6ab74625663cea1558423bb-libre.pdf?1646226203=\u0026response-content-disposition=attachment%3B+filename%3DGiant_Cell_Tumor_of_the_Patella_Tendon_S.pdf\u0026Expires=1740485755\u0026Signature=TEpjxdSgv-CCd2lyOV7PNVP0eYTFjGpxEs~eA-xrjFEvAvfJ0bJV3Li9KfU-Q-BYNTSy6yDZK5xH6hIWdRjzO3KKnSue7OuGA5lHR0WIWpvBLnfZ2GO703a8ElgC8mvSU2Yx3m-Ke~1OH-dVpXi8oGTtrKrp0UQLnUEDRXlyuRypJePIjV~Oycdbvae2Ga0xD-FZnhb7lXAeWp090jzhvI0n9Q5FwZwVOiDf7n2X0E4Fs4QZ2gQd-LQ7q-OtKCdgo5zXgWrC1~Tdr6E2LqVFwGdIv0i3tLJzctsdyqe3yZncSaQuA3ITKIDHNQa29-WIhlFWzIzk-0jW37z8QAYu3A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782605"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782605/Investigation_on_Toxicity_and_Teratogenicity_in_Rats_of_a_Retinoid_Polyamine_Conjugate_with_Potent_Anti_Inflammatory_Properties"><img alt="Research paper thumbnail of Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties" class="work-thumbnail" src="https://attachments.academia-assets.com/81572998/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782605/Investigation_on_Toxicity_and_Teratogenicity_in_Rats_of_a_Retinoid_Polyamine_Conjugate_with_Potent_Anti_Inflammatory_Properties">Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties</a></div><div class="wp-workCard_item"><span>Birth Defects Research Part B: Developmental and Reproductive Toxicology</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Previous studies have shown that N 1 ,N 12-bis(all-trans-retinoyl)spermine (RASP), a retinoid ana...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Previous studies have shown that N 1 ,N 12-bis(all-trans-retinoyl)spermine (RASP), a retinoid analog, inhibits RNase P activity and angiogenesis in the chicken embryo chorioallantoic membrane, demonstrates anti-tumor activity on prostate cancer cells, and acts as anti-inflammatory agent, being more effective and less toxic than all-trans retinoic acid. In an attempt to further characterize the biological profile of RASP, we tested its effects on organ toxicity and teratogenicity by daily oral gavage of RASP at a level of 50 mg/Kg of body weight in two generations of rats. We found that this compound does not induce changes to the body growth, the appearance of physical features, and the animal's reflexes. Additionally, no substantial histopathological lesions were found in brain, heart, lung, thymus, liver, thyroid gland, adrenal gland, pituitary gland, kidneys, spleen, skin, femora, prostate, testis, epididymis, vagina, uterus, and ovaries of RASP-treated animals. These results suggest RASP, as a promising lead compound for the treatment of several dermatological disorders and certain cancer types, has apparently minimal toxic side-effects as revealed in this two-generation reproduction study in rats.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9dda7bdadaed34f65e2f4d07b151c396" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572998,"asset_id":72782605,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572998/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782605"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782605"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782605; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782605]").text(description); $(".js-view-count[data-work-id=72782605]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782605; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782605']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9dda7bdadaed34f65e2f4d07b151c396" } } $('.js-work-strip[data-work-id=72782605]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782605,"title":"Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties","internal_url":"https://www.academia.edu/72782605/Investigation_on_Toxicity_and_Teratogenicity_in_Rats_of_a_Retinoid_Polyamine_Conjugate_with_Potent_Anti_Inflammatory_Properties","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572998,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572998/thumbnails/1.jpg","file_name":"bdrb.pdf","download_url":"https://www.academia.edu/attachments/81572998/download_file","bulk_download_file_name":"Investigation_on_Toxicity_and_Teratogeni.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572998/bdrb-libre.pdf?1646226204=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_on_Toxicity_and_Teratogeni.pdf\u0026Expires=1740485755\u0026Signature=SMGanaet3M3ojyey8DRPjsjmBpwtccimp-s5RiObUx0HqCDc-n20IT6SBs2PslfVnGz3-dmXff8~clfpKZwP54NvAnYt7YQdowCY2G7IxCntIJtKRkYnkBy3TTbePy9aT5mXkhdXn-8wEd8JA~k-O9HRoxufy0wqlIFg4WyeD61bm0AEhq3idcK8PwR26XhPwVTcg-BjoXTRPRSFB1Sr2Iq~3nG9UOoDVwfG5491C23cKH7NdiwXU0C3~kj~HUw2~Irav2xXByd6fRcYCYHhXPV-WLPfRAuA1jr2PVSCHnHJFtPVb6~LH23GkV1jm5aGnnr~-4Hr8BgKQNjxChJzoQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782593"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782593/Increased_Expression_of_Serglycin_in_Specific_Carcinomas_and_Aggressive_Cancer_Cell_Lines"><img alt="Research paper thumbnail of Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines" class="work-thumbnail" src="https://attachments.academia-assets.com/81572875/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782593/Increased_Expression_of_Serglycin_in_Specific_Carcinomas_and_Aggressive_Cancer_Cell_Lines">Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>BioMed Research International</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present pilot study, we examined the presence of serglycin in lung, breast, prostate, and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present pilot study, we examined the presence of serglycin in lung, breast, prostate, and colon cancer and evaluated its expression in cell lines and tissues. We found that serglycin was expressed and constitutively secreted in culture medium in high levels in more aggressive cancer cells. It is worth noticing that aggressive cancer cells that harbor KRAS or EGFR mutations secreted serglycin constitutively in elevated levels. Furthermore, we detected the transcription of an alternative splice variant of serglycin lacking exon 2 in specific cell lines. In a limited number of tissue samples analyzed, serglycin was detected in normal epithelium but was also expressed in higher levels in advanced grade tumors as shown by immunohistochemistry. Serglycin staining was diffuse, granular, and mainly cytoplasmic. In some cancer cells serglycin also exhibited membrane and/or nuclear immunolocalization. Interestingly, the stromal cells of the reactive tumor stroma were positive for sergl...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9df1fa6eb5558b1f93acb28b9bc85531" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572875,"asset_id":72782593,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572875/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782593"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782593"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782593; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782593]").text(description); $(".js-view-count[data-work-id=72782593]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782593; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782593']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9df1fa6eb5558b1f93acb28b9bc85531" } } $('.js-work-strip[data-work-id=72782593]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782593,"title":"Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines","internal_url":"https://www.academia.edu/72782593/Increased_Expression_of_Serglycin_in_Specific_Carcinomas_and_Aggressive_Cancer_Cell_Lines","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572875,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572875/thumbnails/1.jpg","file_name":"690721.pdf","download_url":"https://www.academia.edu/attachments/81572875/download_file","bulk_download_file_name":"Increased_Expression_of_Serglycin_in_Spe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572875/690721-libre.pdf?1646226239=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Expression_of_Serglycin_in_Spe.pdf\u0026Expires=1740485755\u0026Signature=JIQHDcoE7yfP4puZ6C-1XcCdqP9HZ88NGJNBr2bIe0WbtbltF6pUuzNPbef-NLbHusffyoxhRyf0fnjVNMUHf9el2gtqV6gyFcu96uirxUBREzx2wARJwnNOA1zc90LLzVZ7UZHh-aeuxbj4r5nJ-dlXRokkfjFLYilhOPA~0jq0NtqhayzllcwQpvHU2Um42RtWh~KicKCnIkRcIU2th41SBnYZp5vnweDXX3nLu6Jl2gPWCP5xR-g0XdpsxiE0fSbh8DD5lPiewY1TIh8wFT8KW3SV8Ml-Y0bXr3PHrGflRSp-5Kc3-OYT3Q1bn2WuF1qLdM7l9K4AeYxuZQ~reQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":81572874,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572874/thumbnails/1.jpg","file_name":"690721.pdf","download_url":"https://www.academia.edu/attachments/81572874/download_file","bulk_download_file_name":"Increased_Expression_of_Serglycin_in_Spe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572874/690721-libre.pdf?1646226239=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Expression_of_Serglycin_in_Spe.pdf\u0026Expires=1740485756\u0026Signature=XM4t0ev6hr8FXugt3xpyireOQohcJPHE-Z-Sa~SyZ4nukwjbLdpEF~P4IHYIodG9Dhrz7Ohyw7X8CiREK~3DPR9GyBqJ3genbZuCF-UGaUNZr6m5vDi5D27dWwb5di0PBnSBLdVyPsR~raH092dQ9UojDOuSsoftQtbo40jEfqnLVGWmOBIIn7EmP6hgT093rveaPf~jeIS0eKjbmYUw8VhsoRshwHcyHqVxldAKy3vwVpTvvSUNxJL3ILMseLFzxWailjdh7sAHcBTY2myhMCLmwpTdZjqpLJiolpWTW3QK5pO2JCBlSnOKUJkwTs74U5HIY8yAi~mp8FqVpj5Ccg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782584"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782584/Expression_of_vascular_endothelial_growth_factor_and_its_receptor_KDR_Flk_1_in_soft_tissue_sarcomas"><img alt="Research paper thumbnail of Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas" class="work-thumbnail" src="https://attachments.academia-assets.com/81572976/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782584/Expression_of_vascular_endothelial_growth_factor_and_its_receptor_KDR_Flk_1_in_soft_tissue_sarcomas">Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas</a></div><div class="wp-workCard_item"><span>Anticancer research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of the present study was to evaluate the association of vascular endothelial growth facto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of the present study was to evaluate the association of vascular endothelial growth factor (VEGF) and its receptor, KDR/Flk-1, with tumor grade, microvessel density (MVD) and clinical outcome in patients with soft tissue sarcomas (STSs). Tissue specimens of 28 patients with STSs were analyzed immunohistochemically using specific monoclonal antibodies. Tissue samples were obtained prior to any treatment. Half of the STSs exhibited strong expression of VEGF that was associated statistically significantly with high tumor grade. Strong expression of KDR/Flk-1 was detected in only 2 sarcomas. No association was demonstrated between VEGF and KDR/Flk-1 expression. MVD was significantly associated with tumor grade and was higher in sarcomas with strong VEGF expression. Limited data on clinical outcome precluded solid analyses for an association with disease progression. This study provides further evidence on the role of VEGF and MVD in tumor aggressiveness in STSs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="669fe8c6a72d2198f58aadad8b60c422" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572976,"asset_id":72782584,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572976/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782584]").text(description); $(".js-view-count[data-work-id=72782584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "669fe8c6a72d2198f58aadad8b60c422" } } $('.js-work-strip[data-work-id=72782584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782584,"title":"Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas","internal_url":"https://www.academia.edu/72782584/Expression_of_vascular_endothelial_growth_factor_and_its_receptor_KDR_Flk_1_in_soft_tissue_sarcomas","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572976,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572976/thumbnails/1.jpg","file_name":"1477-7819-3-2.pdf","download_url":"https://www.academia.edu/attachments/81572976/download_file","bulk_download_file_name":"Expression_of_vascular_endothelial_growt.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572976/1477-7819-3-2-libre.pdf?1646226211=\u0026response-content-disposition=attachment%3B+filename%3DExpression_of_vascular_endothelial_growt.pdf\u0026Expires=1740485756\u0026Signature=cc0QfMhhAt2SB5TVnZYSxiNWa0IG8vvbxOu~bJQgA03fJZQ7PgCLoTXtrsYVNryqSyO6Ugvh9905lM24Y3sbhOk3pca7GVQu~25KmO~mfZ4ehjPgvWz-xZtCntS8-swF0AuOcrF99wq6QRZnp4ijcdal1VD2mM5IXCfIYnD0q7MCruCEr~vPrmOK6xgVEfNPq5mSySt6LgGL9HgKbzNoOkVw0xPsXw4NwSo6AHJJwJGyQSF5uiBKr-Q~EbIdU7qsQh-9MKmOVKdoyXln-VPN1IzHJhS3QOz7IdmnRf6hrtcy62bPA~CRERX9xKfHSMPuUQSVoo9wXheqaFyZpgWADg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782578"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782578/The_inhibition_of_aromatase_alters_the_mechanical_and_rheological_properties_of_non_small_cell_lung_cancer_cell_lines_affecting_cell_migration"><img alt="Research paper thumbnail of The inhibition of aromatase alters the mechanical and rheological properties of non-small-cell lung cancer cell lines affecting cell migration" class="work-thumbnail" src="https://attachments.academia-assets.com/81572970/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782578/The_inhibition_of_aromatase_alters_the_mechanical_and_rheological_properties_of_non_small_cell_lung_cancer_cell_lines_affecting_cell_migration">The inhibition of aromatase alters the mechanical and rheological properties of non-small-cell lung cancer cell lines affecting cell migration</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tumor invasion and metastasis are key aspects of non-small cell lung cancer (NSCLC). During migra...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tumor invasion and metastasis are key aspects of non-small cell lung cancer (NSCLC). During migration, cells undergo mechanical alterations. The mechanical phenotype of breast cancer cells is correlated with aromatase gene expression. We have previously shown that targeting aromatase is a promising strategy for NSCLC. The aim of this study was to examine morphological and mechanical changes of NSCLC cells, upon treatment with aromatase inhibitor and correlate their ability to migrate and invade. In vitro experiments were performed using H23 and A549 NSCLC cell lines and exemestane was used for aromatase inhibition. We demonstrated that exemestane reduced H23 cell migration and invasion and caused changes in cell morphology including increased vacuolar structures and greater pleomorphism. In addition, exemestane changed the distribution of α-tubulin in H23 and A549 cells in a way that might destabilize microtubules polymerization. These effects were associated with increased cell viscosity and decreased elastic shear modulus. Although exemestane caused similar effects in A549 cells regarding viscosity and elastic shear modulus, it did not affect A549 cell migration and caused an increase in invasion. The increased invasion was in line with vimentin perinuclear localization. Our data show that the treatment of NSCLC cells with an aromatase inhibitor not only affects cell migration and invasion but also alters the mechanical properties of the cells. It suggests that the different origin of cancer cells is associated with different morphological characteristics and mechanical behavior.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="de7f8625d875c2d8cf4c9d279f6f412a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572970,"asset_id":72782578,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572970/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782578"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782578"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782578; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782578]").text(description); $(".js-view-count[data-work-id=72782578]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782578; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782578']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "de7f8625d875c2d8cf4c9d279f6f412a" } } $('.js-work-strip[data-work-id=72782578]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782578,"title":"The inhibition of aromatase alters the mechanical and rheological properties of non-small-cell lung cancer cell lines affecting cell migration","internal_url":"https://www.academia.edu/72782578/The_inhibition_of_aromatase_alters_the_mechanical_and_rheological_properties_of_non_small_cell_lung_cancer_cell_lines_affecting_cell_migration","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572970,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572970/thumbnails/1.jpg","file_name":"82769308.pdf","download_url":"https://www.academia.edu/attachments/81572970/download_file","bulk_download_file_name":"The_inhibition_of_aromatase_alters_the_m.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572970/82769308-libre.pdf?1646226212=\u0026response-content-disposition=attachment%3B+filename%3DThe_inhibition_of_aromatase_alters_the_m.pdf\u0026Expires=1740485756\u0026Signature=VaX6swwHMbkwH1VvVVs3OyDrAKiVyFrz6zAC-rgF-B7BH9kmhyElQnY7ZgBAhMNouhlFzIfSaLiyjKZW7paC3V8xX~SQeclKxHU-760CeK7bNTAJQsqxrf~D3QWnkL171uvZPg5JlAxTtemZrEx5KwCUy3LE7Q6rKrKngV0h3G-k~kzyeHs710hisFeL7v5-Qy0cZS3eDDybk8yvAIR0kCe4GO~Xs8EWXIJ0lK84UWttrX6QGBIsDhrYXMq3R8gwr84u-8VbCbxVs1D9WxOnQ6D92UAb5VTAobuY1cYTYw7T8XA27uVwdRULYWJ0dRPvb4A4Tjm8Vlcb0iYYWbAAlg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782570"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/72782570/Aggressive_angiomyxoma_of_the_vagina_a_case_report_and_review_of_the_literature"><img alt="Research paper thumbnail of Aggressive angiomyxoma of the vagina: a case report and review of the literature" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/72782570/Aggressive_angiomyxoma_of_the_vagina_a_case_report_and_review_of_the_literature">Aggressive angiomyxoma of the vagina: a case report and review of the literature</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aggressive angiomyxomas are rare soft tissue tumours. They are mainly found females. Steeper and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aggressive angiomyxomas are rare soft tissue tumours. They are mainly found females. Steeper and Rosai described these tumors for the first time in 1983. The diagnosis and the treatment are difficult. The recurrence is frequent. The authors report a case of aggressive angiomyxoma of the vagina and the pelvis, diagnosed in a 34-old-woman. They discuss clinical symptoms and different signs allowing the diagnosis. Therapeutic management is also discussed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782570"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782570"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782570; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782570]").text(description); $(".js-view-count[data-work-id=72782570]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782570; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782570']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72782570]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782570,"title":"Aggressive angiomyxoma of the vagina: a case report and review of the literature","internal_url":"https://www.academia.edu/72782570/Aggressive_angiomyxoma_of_the_vagina_a_case_report_and_review_of_the_literature","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782561/Apolipoprotein_A_I_modulates_processes_associated_with_diet_induced_nonalcoholic_fatty_liver_disease_in_mice"><img alt="Research paper thumbnail of Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/81573030/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782561/Apolipoprotein_A_I_modulates_processes_associated_with_diet_induced_nonalcoholic_fatty_liver_disease_in_mice">Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice</a></div><div class="wp-workCard_item"><span>Molecular Medicine</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein (HDL). We investigate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein (HDL). We investigated the involvement of apoA-I in diet-induced accumulation of triglycerides in hepatocytes and its potential role in the treatment of nonalcoholic fatty liver disease (NAFLD). ApoA-I-deficient (apoA-I-/-) mice showed increased diet-induced hepatic triglyceride deposition and disturbed hepatic histology while they exhibited reduced glucose tolerance and insulin sensitivity. Quantification of FASN (fatty acid synthase 1), DGAT-1 (diacylglycerol O-acyltransferase 1), and PPARγ (peroxisome proliferator-activated receptor γ) mRNA expression suggested that the increased hepatic triglyceride content of the apoA-I-/mice was not due to de novo synthesis of triglycerides. Similarly, metabolic profiling did not reveal differences in the energy expenditure between the two mouse groups. However, apoA-I-/mice exhibited enhanced intestinal absorption of dietary triglycerides (3.6 ± 0.5 mg/dL/min for apoA-I-/versus 2.0 ± 0.7 mg/dL/min for C57BL/6 mice, P < 0.05), accelerated clearance of postprandial triglycerides and a reduced rate of hepatic very low density lipoprotein (VLDL) triglyceride secretion (9.8 ± 1.1 mg/dL/min for apoA-I-/versus 12.5 ± 1.3 mg/dL/min for C57BL/6 mice, P < 0.05). In agreement with these findings, adenovirus-mediated gene transfer of apoA-I Milano in apoA-I-/mice fed a Western-type diet for 12 wks resulted in a significant reduction in hepatic triglyceride content and an improvement of hepatic histology and architecture. Our data extend the current knowledge on the functions of apoA-I, indicating that in addition to its wellestablished properties in atheroprotection, it is also an important modulator of processes associated with diet-induced hepatic lipid deposition and NAFLD development in mice. Our findings raise the interesting possibility that expression of therapeutic forms of apoA-I by gene therapy approaches may have a beneficial effect on NAFLD.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9ac21ccaada269144127514bfdde71b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81573030,"asset_id":72782561,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81573030/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782561; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782561]").text(description); $(".js-view-count[data-work-id=72782561]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782561; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782561']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e9ac21ccaada269144127514bfdde71b" } } $('.js-work-strip[data-work-id=72782561]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782561,"title":"Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice","internal_url":"https://www.academia.edu/72782561/Apolipoprotein_A_I_modulates_processes_associated_with_diet_induced_nonalcoholic_fatty_liver_disease_in_mice","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81573030,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81573030/thumbnails/1.jpg","file_name":"molmed.2012.00113.pdf","download_url":"https://www.academia.edu/attachments/81573030/download_file","bulk_download_file_name":"Apolipoprotein_A_I_modulates_processes_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81573030/molmed.2012.00113-libre.pdf?1646226195=\u0026response-content-disposition=attachment%3B+filename%3DApolipoprotein_A_I_modulates_processes_a.pdf\u0026Expires=1740429569\u0026Signature=KHbtFP0yFnsQs5FPFyucDceSkpz2RFdbi8kXPpElii9m5KAn39uk50kXuxC2uceWBdFw46PsaWargEZZFmqKMjh3KZq6fHtY-C1Vy~EOWGpUcE7KcQeQyYVgZfZbcSt1XxBwZUj8Zdq5vEn4zxI0aen1snlJZZsJxKHHD2QQJJggwT1-kby3M3NkWXzSoLbLF5ai-71ysT8Rs9qabferv2COI-fOmr7CvPT7d7yMs20i5-2QH9I0kPU27HboWn~9jgam9N2xF2FP0JCv0imYmJTjEzMp~50hygAjucrxKrgqzV~S65-JkO-sMq4NRHQDfTdN6ny5CY6MBIIvKv0m4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782551"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/72782551/Chronic_Alcohol_Consumption_Is_a_Major_Risk_Factor_for_Pancreatic_Necrosis_in_Acute_Pancreatitis"><img alt="Research paper thumbnail of Chronic Alcohol Consumption Is a Major Risk Factor for Pancreatic Necrosis in Acute Pancreatitis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/72782551/Chronic_Alcohol_Consumption_Is_a_Major_Risk_Factor_for_Pancreatic_Necrosis_in_Acute_Pancreatitis">Chronic Alcohol Consumption Is a Major Risk Factor for Pancreatic Necrosis in Acute Pancreatitis</a></div><div class="wp-workCard_item"><span>American Journal of Gastroenterology - AMER J GASTROENTEROL</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND:Much of the late morbidity and mortality of acute pancreatitis (AP) is attributed to c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND:Much of the late morbidity and mortality of acute pancreatitis (AP) is attributed to complications of pancreatic necrosis (PNEC). Early diagnosis of PNEC in high-risk patients is critical to management. Hemoconcentration is one risk factor for PNEC, but additional risk factors are likely implicated.AIMS:(1) To evaluate a series of preselected clinical factors in a prospectively collected cohort with AP to identify risk factors for PNEC and (2) to verify the relative risk of any newly identified factor(s) by retrospective analysis of a large patient cohort.METHODS:Phase I: 102 AP patients were prospectively ascertained, of which 77 (mean age 49 yr; 35 women, 42 men) underwent contrast-enhanced computerized tomography (CECT) and were studied. Eleven subjects developed PNEC (14%). Binary logistic regression was performed to identify any clinical factors associated with PNEC. Phase II: 1,474 anonymized patients admitted to the hospital with a diagnosis of AP were electronical...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782551"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782551"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782551; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782551]").text(description); $(".js-view-count[data-work-id=72782551]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782551; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782551']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72782551]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782551,"title":"Chronic Alcohol Consumption Is a Major Risk Factor for Pancreatic Necrosis in Acute Pancreatitis","internal_url":"https://www.academia.edu/72782551/Chronic_Alcohol_Consumption_Is_a_Major_Risk_Factor_for_Pancreatic_Necrosis_in_Acute_Pancreatitis","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782543"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/72782543/Biomechanical_and_structural_changes_following_the_decellularization_of_bovine_pericardial_tissues_for_use_as_a_tissue_engineering_scaffold"><img alt="Research paper thumbnail of Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/72782543/Biomechanical_and_structural_changes_following_the_decellularization_of_bovine_pericardial_tissues_for_use_as_a_tissue_engineering_scaffold">Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold</a></div><div class="wp-workCard_item"><span>Journal of Materials Science: Materials in Medicine</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To achieve natural scaffolds for tissue engineering applications we decellularized bovine pericar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To achieve natural scaffolds for tissue engineering applications we decellularized bovine pericardial (BP) tissues according to two different protocols: a novel treatment based on Triton(®) X-100 (12 h, 4 °C) (BP1) and a trypsin/EDTA treatment (37 °C, 48 h) (BP2). Results were compared with commercially available acellular xenogeneic biomaterials, Veritas(®) and Collamed(®). Biomechanical characteristics, high (E(h)) and low (E(l)) modulus of elasticity, of the fresh untreated tissue varied with the anatomical direction (apex to base (T) to transverse (L)) (mean ± SDEV): (41.63 ± 14.65-48.12 ± 10.19 MPa and 0.27 ± 0.05-0.30 ± 0.12 MPa respectively). BP1 had no mechanical effect (44.65 ± 19.73-52.67 ± 7.59 MPa and 0.37 ± 0.14-0.37 ± 0.11 MPa, respectively) but BP2 resulted in significant decrease in E(h) and E(l) (20.96 ± 8.17-36.82 ± 3.23 MPa and 0.20 ± 0.06-0.23 ± 0.06 MPa). Hysteresis ratio (h) varied (19-26 % of the loading energy) independently of anatomical direction. Glycosaminoglycans content was unaffected by BP1, while 22 % of chondroitin/dermatan sulphate and 60 % of hyaluronan were removed after BP2 treatment. Endothelial cell adhesion was achieved after 24 h and 3 days cell culture.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782543"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782543"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782543; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782543]").text(description); $(".js-view-count[data-work-id=72782543]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782543; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782543']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72782543]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782543,"title":"Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold","internal_url":"https://www.academia.edu/72782543/Biomechanical_and_structural_changes_following_the_decellularization_of_bovine_pericardial_tissues_for_use_as_a_tissue_engineering_scaffold","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782533"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782533/The_MAPK_AP_1_Runx2_signalling_axes_are_implicated_in_chondrosarcoma_pathobiology_either_independently_or_via_up_regulation_of_VEGF"><img alt="Research paper thumbnail of The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF" class="work-thumbnail" src="https://attachments.academia-assets.com/81572952/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782533/The_MAPK_AP_1_Runx2_signalling_axes_are_implicated_in_chondrosarcoma_pathobiology_either_independently_or_via_up_regulation_of_VEGF">The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF</a></div><div class="wp-workCard_item"><span>Histopathology</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either indepen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF Aims: To investigate whether and how the JNK ⁄ ERK-AP-1 ⁄-Runx2 signalling pathways and vascular endothelial growth factor (VEGF) are engaged in the pathogenesis of cartilaginous tumours. Chondrosarcoma is the third most common primary skeletal malignancy. Nevertheless, the molecular events underlying its pathogenesis remain elusive. JNK ⁄ ERK MAPKs and their downstream effectors, c-Jun and c-Fos (AP-1), are involved in chondroblastic differention ⁄ proliferation. These proteins interact with the Runx2 transcription factor, which is also implicated in chondroblast biology. VEGF, a key angiogenic factor, is up-regulated in human chondrosarcomas. Methods and results: Normal cartilage and neoplastic cells from 45 chondrosarcomas and 21 enchondromas were investigated immunohistochemically. We evaluated the cellular levels of JNK2, p-JNK2 (phosphorylated ⁄ activated JNK2), its main substrate, c-Jun, pc-Jun (phosphorylated ⁄ activated c-Jun) and c-Fos. Moreover, the levels of pERK (phosphorylated ⁄ activated ERK), Runx2 and VEGF were assessed. Positive immunostaining for all proteins was observed in the majority of the examined chondrosarcomas and in a small fraction of enchondromas. The expression levels of all proteins were positively and significantly correlated with each other. These levels were substantially augmented in high-grade compared with lowgrade chondrosarcomas and in low-grade tumours compared with benign enchondromas, implying a potential use as molecular markers for prediction of high-grade neoplasms. Conclusions: The JNK ⁄ ERK-AP-1 ⁄-Runx2 signal transduction 'network' is associated with chondroblastic malignant transformation and chondrosarcoma development, either separately or through coordinated induction of VEGF.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c5389977064fa671d6e19ecea9f3b86e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572952,"asset_id":72782533,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572952/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782533"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782533"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782533; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782533]").text(description); $(".js-view-count[data-work-id=72782533]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782533; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782533']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c5389977064fa671d6e19ecea9f3b86e" } } $('.js-work-strip[data-work-id=72782533]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782533,"title":"The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF","internal_url":"https://www.academia.edu/72782533/The_MAPK_AP_1_Runx2_signalling_axes_are_implicated_in_chondrosarcoma_pathobiology_either_independently_or_via_up_regulation_of_VEGF","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572952,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572952/thumbnails/1.jpg","file_name":"j.1365-2559.2005.02266.x20220302-956-kkju09.pdf","download_url":"https://www.academia.edu/attachments/81572952/download_file","bulk_download_file_name":"The_MAPK_AP_1_Runx2_signalling_axes_are.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572952/j.1365-2559.2005.02266.x20220302-956-kkju09-libre.pdf?1646226217=\u0026response-content-disposition=attachment%3B+filename%3DThe_MAPK_AP_1_Runx2_signalling_axes_are.pdf\u0026Expires=1740429569\u0026Signature=HGhDElaO2i-wtbaEOyzdLwMQ4AS4AD6wIRgb8SmtAHXa31l6XgVB7KYtdcn5SLvlNPBZKspSiZ-4DoRjlfIoPn8G0jerT0vbNb7lZHLDC1HVn3ACFq6NNsZAIxjQS0Rjw45Yw7ceJ8CZZaWPww4CFOjC7Qx-s9k8DifYV~gZmAdXWvD-f0N5HUdez5lWX0pr2NGEsRUQ-lm9myT1lM8b5~TjRced5xP~RIEA80Cu78cRju~QcCytQwIRh83gUWNLJS-14Mu7ZlBSjzX0aB340tP2nlSQo9xJ2qHKdnM1TeFFMxA8nOA9ATmftmYo5mhu0y5V4TLNL4df~LSt6k5p4g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72782526"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72782526/Systemic_silicosis_that_involves_the_pancreas"><img alt="Research paper thumbnail of Systemic silicosis that involves the pancreas" class="work-thumbnail" src="https://attachments.academia-assets.com/81572951/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72782526/Systemic_silicosis_that_involves_the_pancreas">Systemic silicosis that involves the pancreas</a></div><div class="wp-workCard_item"><span>Gastrointestinal …</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="103067bd2f63c0f1a14da88759affa6a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81572951,"asset_id":72782526,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81572951/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72782526"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72782526"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72782526; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72782526]").text(description); $(".js-view-count[data-work-id=72782526]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72782526; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72782526']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "103067bd2f63c0f1a14da88759affa6a" } } $('.js-work-strip[data-work-id=72782526]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72782526,"title":"Systemic silicosis that involves the pancreas","internal_url":"https://www.academia.edu/72782526/Systemic_silicosis_that_involves_the_pancreas","owner_id":32809036,"coauthors_can_edit":true,"owner":{"id":32809036,"first_name":"Dionysios Papachristou","middle_initials":null,"last_name":"Md","page_name":"DionysiosPapachristouMd","domain_name":"upatras","created_at":"2015-07-05T08:17:44.524-07:00","display_name":"Dionysios Papachristou Md","url":"https://upatras.academia.edu/DionysiosPapachristouMd"},"attachments":[{"id":81572951,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81572951/thumbnails/1.jpg","file_name":"j.gie.2005.07.01020220302-20746-151cggj.pdf","download_url":"https://www.academia.edu/attachments/81572951/download_file","bulk_download_file_name":"Systemic_silicosis_that_involves_the_pan.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81572951/j.gie.2005.07.01020220302-20746-151cggj-libre.pdf?1646226217=\u0026response-content-disposition=attachment%3B+filename%3DSystemic_silicosis_that_involves_the_pan.pdf\u0026Expires=1740485756\u0026Signature=HME1avCzFrC7Z0TdMlgY772FQBu10Skl5rn7QH7MUTpbG-Y8yYI3SO41VTOqWWNmQY0oMEKNz9vqCSyBU4cM17DDhao-~6EflfCcThDCq-RknQ6fXHe3oXvVfrBIq2bNqZdxK6VDkGYPUjyrC6M9zEEBPSbAJCfQhtBoWGB3cTK-HxM4blGRjjB9eeBvUfnoxILYGb7Hak-hEhOzbOzm1Yq-1SutmZHi86gP964qBZNLHP5-pr~-dHuOjSkfKUwMtyiKvdthxkX8Nzty8dORtShCNTJZtDzkcZhDRGQu-cqJWf0dCwpkx4mqTZc80JcTP0AYnXNdwEWIaF7JGHeIEg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; } .sign-in-with-apple-button > div { margin: 0 auto; / This centers the Apple-rendered button horizontally }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "7c87c89bf91d62d8046fb1927bfecfbeb4a65c89a24acb81491e3baf26590a13", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="kcreM768QuW-0D7Y0c8CxyLJqZ6icRVEm02on0Ku84YHlKt4w4KD--twGmkdaZ9qY_ifHVrITZ07COJ4wrZNkg" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://upatras.academia.edu/DionysiosPapachristouMd" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="seGGoJ2lcQKUmr1fe5q8_0vQLBYJ7p1ykR2MkkaAqdEnv_Pr4JuwHME6me63PCFSCuEalfFXxasxWMZ1xpgXxQ" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>