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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Clinical Sciences</h1><div class="u-tcGrayDark">88,714 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Clinical Sciences</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Clinical_Sciences">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Clinical_Sciences/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Clinical_Sciences/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Clinical_Sciences/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Clinical_Sciences">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11231053" data-work_id="11231053" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11231053/CD5_provides_viability_signals_to_B_cells_from_a_subset_of_B_CLL_patients_by_a_mechanism_that_involves_PKC">CD5 provides viability signals to B cells from a subset of B-CLL patients by a mechanism that involves PKC</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">B-chronic lymphocytic leukaemia (B-CLL) is a heterogeneous disease characterized by an accumulation of B lymphocytes expressing CD5. To date, the biological significance of this molecule in B-CLL B cells remains to be elucidated. In this... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11231053" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">B-chronic lymphocytic leukaemia (B-CLL) is a heterogeneous disease characterized by an accumulation of B lymphocytes expressing CD5. To date, the biological significance of this molecule in B-CLL B cells remains to be elucidated. In this study, we have analysed the functional consequences of the binding of an anti-CD5 antibody on B-CLL B cells. To this purpose, we have measured the percentage of viability of B-CLL B cells in the presence or in the absence of anti-CD5 antibodies and also examined some of the biochemical events downstream the CD5-signalling. We demonstrate that anti-CD5 induces phosphorylation of protein tyrosine kinases and protein kinase C (PKC), while no activation of Akt/PKB and MAPKs is detected. This signalling cascade results in viability in a group of patients in which we observe an increase of Mcl-1 levels, whereas the levels of bcl-2, bcl-xL and XIAP do not change. We also report that this pathway leads to IL-10 production, an immunoregulatory cytokine that might act as an autocrine growth factor for leukaemic B cells. Inhibition of PKC prevents the induction of Mcl-1 and IL-10, suggesting that the activation of PKC plays an important role in the CD5-mediated survival signals in B cells from a subset of B-CLL patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11231053" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dde9069ae2b7245f4cc3d02e2cea7f6a" rel="nofollow" data-download="{"attachment_id":46805109,"asset_id":11231053,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46805109/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27139427" href="https://independent.academia.edu/PalomaPerezAciego">Paloma Perez-Aciego</a><script data-card-contents-for-user="27139427" type="text/json">{"id":27139427,"first_name":"Paloma","last_name":"Perez-Aciego","domain_name":"independent","page_name":"PalomaPerezAciego","display_name":"Paloma Perez-Aciego","profile_url":"https://independent.academia.edu/PalomaPerezAciego?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11231053 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11231053"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11231053, container: ".js-paper-rank-work_11231053", }); 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$(".js-view-count[data-work-id=11231053]").text(description); $(".js-view-count-work_11231053").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11231053").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11231053"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="14109" rel="nofollow" href="https://www.academia.edu/Documents/in/Leukemia">Leukemia</a>, <script data-card-contents-for-ri="14109" type="text/json">{"id":14109,"name":"Leukemia","url":"https://www.academia.edu/Documents/in/Leukemia?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24731" rel="nofollow" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a>, <script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" rel="nofollow" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a>, <script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="140106" rel="nofollow" href="https://www.academia.edu/Documents/in/Protein_Tyrosine_Kinase">Protein Tyrosine Kinase</a><script data-card-contents-for-ri="140106" type="text/json">{"id":140106,"name":"Protein Tyrosine Kinase","url":"https://www.academia.edu/Documents/in/Protein_Tyrosine_Kinase?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11231053]'), work: {"id":11231053,"title":"CD5 provides viability signals to B cells from a subset of B-CLL patients by a mechanism that involves PKC","created_at":"2015-03-03T07:42:01.145-08:00","url":"https://www.academia.edu/11231053/CD5_provides_viability_signals_to_B_cells_from_a_subset_of_B_CLL_patients_by_a_mechanism_that_involves_PKC?f_ri=244814","dom_id":"work_11231053","summary":"B-chronic lymphocytic leukaemia (B-CLL) is a heterogeneous disease characterized by an accumulation of B lymphocytes expressing CD5. To date, the biological significance of this molecule in B-CLL B cells remains to be elucidated. In this study, we have analysed the functional consequences of the binding of an anti-CD5 antibody on B-CLL B cells. To this purpose, we have measured the percentage of viability of B-CLL B cells in the presence or in the absence of anti-CD5 antibodies and also examined some of the biochemical events downstream the CD5-signalling. We demonstrate that anti-CD5 induces phosphorylation of protein tyrosine kinases and protein kinase C (PKC), while no activation of Akt/PKB and MAPKs is detected. This signalling cascade results in viability in a group of patients in which we observe an increase of Mcl-1 levels, whereas the levels of bcl-2, bcl-xL and XIAP do not change. We also report that this pathway leads to IL-10 production, an immunoregulatory cytokine that might act as an autocrine growth factor for leukaemic B cells. Inhibition of PKC prevents the induction of Mcl-1 and IL-10, suggesting that the activation of PKC plays an important role in the CD5-mediated survival signals in B cells from a subset of B-CLL patients.","downloadable_attachments":[{"id":46805109,"asset_id":11231053,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27139427,"first_name":"Paloma","last_name":"Perez-Aciego","domain_name":"independent","page_name":"PalomaPerezAciego","display_name":"Paloma Perez-Aciego","profile_url":"https://independent.academia.edu/PalomaPerezAciego?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":14109,"name":"Leukemia","url":"https://www.academia.edu/Documents/in/Leukemia?f_ri=244814","nofollow":true},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=244814","nofollow":true},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=244814","nofollow":true},{"id":140106,"name":"Protein Tyrosine Kinase","url":"https://www.academia.edu/Documents/in/Protein_Tyrosine_Kinase?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes?f_ri=244814"},{"id":951344,"name":"Growth Factor","url":"https://www.academia.edu/Documents/in/Growth_Factor?f_ri=244814"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival?f_ri=244814"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24348904" data-work_id="24348904" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24348904/Lead_Explantation_Late_After_Atrial_Perforation">Lead Explantation Late After Atrial Perforation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">TRIGANO, A.J., ET AL.: Lead Explantation Late After Atrial Perforation. Tbis report describes the case of a patient in wbom atrial perforation witb penetration of tbe tboracic wall was diagnosed 2 years after tbe implantation of an... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24348904" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">TRIGANO, A.J., ET AL.: Lead Explantation Late After Atrial Perforation. Tbis report describes the case of a patient in wbom atrial perforation witb penetration of tbe tboracic wall was diagnosed 2 years after tbe implantation of an Accufix lead. Despite tbis complication, atrial detection in the bipolar mode and ventricular pacing were normal. Digital fluoroscopy detected a fracture witb extrusion of a short segment of tbe retention wire. Tbe rupture of tbe retention wire might have been the result, but was not the cause of tbe perforation. (PACE 1996; 19:1268-1269 atrial perforation, Accufix^'^ atrial lead</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24348904" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8e18c82df4238dfabf94daa8438a40d6" rel="nofollow" data-download="{"attachment_id":44682949,"asset_id":24348904,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44682949/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46742101" href="https://independent.academia.edu/ThierryCaus">Thierry Caus</a><script data-card-contents-for-user="46742101" type="text/json">{"id":46742101,"first_name":"Thierry","last_name":"Caus","domain_name":"independent","page_name":"ThierryCaus","display_name":"Thierry Caus","profile_url":"https://independent.academia.edu/ThierryCaus?f_ri=244814","photo":"https://0.academia-photos.com/46742101/39330372/32586295/s65_thierry.caus.jpeg"}</script></span></span></li><li class="js-paper-rank-work_24348904 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24348904"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24348904, container: ".js-paper-rank-work_24348904", }); });</script></li><li class="js-percentile-work_24348904 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24348904; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24348904"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24348904 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24348904"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24348904; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24348904]").text(description); $(".js-view-count-work_24348904").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24348904").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24348904"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1131" rel="nofollow" href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a>, <script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="413301" rel="nofollow" href="https://www.academia.edu/Documents/in/Perforation">Perforation</a><script data-card-contents-for-ri="413301" type="text/json">{"id":413301,"name":"Perforation","url":"https://www.academia.edu/Documents/in/Perforation?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24348904]'), work: {"id":24348904,"title":"Lead Explantation Late After Atrial Perforation","created_at":"2016-04-12T22:30:04.466-07:00","url":"https://www.academia.edu/24348904/Lead_Explantation_Late_After_Atrial_Perforation?f_ri=244814","dom_id":"work_24348904","summary":"TRIGANO, A.J., ET AL.: Lead Explantation Late After Atrial Perforation. Tbis report describes the case of a patient in wbom atrial perforation witb penetration of tbe tboracic wall was diagnosed 2 years after tbe implantation of an Accufix lead. Despite tbis complication, atrial detection in the bipolar mode and ventricular pacing were normal. Digital fluoroscopy detected a fracture witb extrusion of a short segment of tbe retention wire. Tbe rupture of tbe retention wire might have been the result, but was not the cause of tbe perforation. (PACE 1996; 19:1268-1269 atrial perforation, Accufix^'^ atrial lead","downloadable_attachments":[{"id":44682949,"asset_id":24348904,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":46742101,"first_name":"Thierry","last_name":"Caus","domain_name":"independent","page_name":"ThierryCaus","display_name":"Thierry Caus","profile_url":"https://independent.academia.edu/ThierryCaus?f_ri=244814","photo":"https://0.academia-photos.com/46742101/39330372/32586295/s65_thierry.caus.jpeg"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":413301,"name":"Perforation","url":"https://www.academia.edu/Documents/in/Perforation?f_ri=244814","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_53339818" data-work_id="53339818" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/53339818/Vasopressin_Excess_and_Hyponatremia">Vasopressin Excess and Hyponatremia</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">is a common electrolyte disorder that frequently is overlooked and undertreated. Although the pathophysiological process of hyponatremia is complex, arginine vasopressin (AVP) is a common etiologic factor. Excess AVP release by osmotic or... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_53339818" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">is a common electrolyte disorder that frequently is overlooked and undertreated. Although the pathophysiological process of hyponatremia is complex, arginine vasopressin (AVP) is a common etiologic factor. Excess AVP release by osmotic or nonosmotic stimuli or both can lead to sodium and water imbalance. Conventional treatment options for hyponatremia, including water restriction and administration of sodium chloride with or without loop diuretics, do not directly address the underlying water retention induced by excess AVP in many cases. Clinical trials showed that AVP-receptor antagonists, including lixivaptan, tolvaptan, and conivaptan, produce aquaresis, the electrolyte-sparing excretion of free water, to correct serum sodium concentration. We review results from recent clinical trials involving AVP-receptor antagonists in the treatment of hyponatremia associated with AVP excess.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/53339818" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="91760683b7cfa0df4f93825800a9e195" rel="nofollow" data-download="{"attachment_id":70229526,"asset_id":53339818,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70229526/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="107572382" href="https://independent.academia.edu/chithuanpham">chi thuan pham</a><script data-card-contents-for-user="107572382" type="text/json">{"id":107572382,"first_name":"chi thuan","last_name":"pham","domain_name":"independent","page_name":"chithuanpham","display_name":"chi thuan pham","profile_url":"https://independent.academia.edu/chithuanpham?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_53339818 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="53339818"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 53339818, container: ".js-paper-rank-work_53339818", }); 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$(".js-view-count[data-work-id=53339818]").text(description); $(".js-view-count-work_53339818").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_53339818").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="53339818"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="622" rel="nofollow" href="https://www.academia.edu/Documents/in/Nephrology">Nephrology</a>, <script data-card-contents-for-ri="622" type="text/json">{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="653" rel="nofollow" href="https://www.academia.edu/Documents/in/Urology">Urology</a>, <script data-card-contents-for-ri="653" type="text/json">{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="88114" rel="nofollow" href="https://www.academia.edu/Documents/in/Congestive_Heart_Failure">Congestive Heart Failure</a>, <script data-card-contents-for-ri="88114" type="text/json">{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=53339818]'), work: {"id":53339818,"title":"Vasopressin Excess and Hyponatremia","created_at":"2021-09-25T16:43:44.414-07:00","url":"https://www.academia.edu/53339818/Vasopressin_Excess_and_Hyponatremia?f_ri=244814","dom_id":"work_53339818","summary":"is a common electrolyte disorder that frequently is overlooked and undertreated. Although the pathophysiological process of hyponatremia is complex, arginine vasopressin (AVP) is a common etiologic factor. Excess AVP release by osmotic or nonosmotic stimuli or both can lead to sodium and water imbalance. Conventional treatment options for hyponatremia, including water restriction and administration of sodium chloride with or without loop diuretics, do not directly address the underlying water retention induced by excess AVP in many cases. Clinical trials showed that AVP-receptor antagonists, including lixivaptan, tolvaptan, and conivaptan, produce aquaresis, the electrolyte-sparing excretion of free water, to correct serum sodium concentration. We review results from recent clinical trials involving AVP-receptor antagonists in the treatment of hyponatremia associated with AVP excess.","downloadable_attachments":[{"id":70229526,"asset_id":53339818,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":107572382,"first_name":"chi thuan","last_name":"pham","domain_name":"independent","page_name":"chithuanpham","display_name":"chi thuan pham","profile_url":"https://independent.academia.edu/chithuanpham?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology?f_ri=244814","nofollow":true},{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology?f_ri=244814","nofollow":true},{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":1028433,"name":"Hyponatremia","url":"https://www.academia.edu/Documents/in/Hyponatremia?f_ri=244814"},{"id":1524090,"name":"Benzamides","url":"https://www.academia.edu/Documents/in/Benzamides?f_ri=244814"},{"id":2583478,"name":"Neuropeptide","url":"https://www.academia.edu/Documents/in/Neuropeptide?f_ri=244814"},{"id":3903683,"name":"Arginine Vasopressin","url":"https://www.academia.edu/Documents/in/Arginine_Vasopressin?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4559902" data-work_id="4559902" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4559902/Citrate_anticoagulation_abolishes_degranulation_of_polymorphonuclear_cells_and_platelets_and_reduces_oxidative_stress_during_haemodialysis">Citrate anticoagulation abolishes degranulation of polymorphonuclear cells and platelets and reduces oxidative stress during haemodialysis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background. During haemodialysis (HD), polymorphonuclear cells (PMNs) and platelets are activated and release various granule products, including myeloperoxidase (MPO) and platelet factor 4 (PF4). MPO triggers the generation of reactive... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_4559902" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background. During haemodialysis (HD), polymorphonuclear cells (PMNs) and platelets are activated and release various granule products, including myeloperoxidase (MPO) and platelet factor 4 (PF4). MPO triggers the generation of reactive oxygen species, leading to irreversible protein, carbohydrate and lipid modification. PF4 probably also contributes to oxidative stress. As previously shown, HD-induced PMN degranulation is almost completely abolished during citrate anticoagulation, most probably due to its calcium chelation ability. Methods. In the present study, apart from HDinduced PMN and platelet degranulation, oxidative stress was analysed during three modes of anticoagulation. Heparin, dalteparin and citrate (HD hep , HD dal and HD cit ) were compared in a randomized, crossover fashion in eight chronic HD patients. Multiple blood samples were taken during the third HD session of each modality, from both the afferent and efferent line. Besides the degranulation markers MPO and PF4, various markers of oxidative stress were measured, including oxidized low-density lipoprotein (ox-LDL), malondialdehyde (MDA) and carboxymethyllysine (CML). Results. During HD hep and HD dal , marked degranulation was observed shortly after the start of HD. In contrast, during HD cit , PF4 and MPO levels remained unaltered, suggesting no release at all. After 1 week of HD cit , ox-LDL levels were markedly reduced [median 26% (3-65%), P ¼ 0.01], if compared with HD hep and HD dal . As regards MDA and CML, no differences were found.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4559902" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="53c360dc51f53c2ef1ede147130a0a62" rel="nofollow" data-download="{"attachment_id":31937260,"asset_id":4559902,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/31937260/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5701984" href="https://independent.academia.edu/MarianneSchoorl">Marianne Schoorl</a><script data-card-contents-for-user="5701984" type="text/json">{"id":5701984,"first_name":"Marianne","last_name":"Schoorl","domain_name":"independent","page_name":"MarianneSchoorl","display_name":"Marianne Schoorl","profile_url":"https://independent.academia.edu/MarianneSchoorl?f_ri=244814","photo":"https://0.academia-photos.com/5701984/2476159/2876684/s65_marianne.schoorl.jpg"}</script></span></span></li><li class="js-paper-rank-work_4559902 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4559902"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4559902, container: ".js-paper-rank-work_4559902", }); 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$(".js-view-count[data-work-id=4559902]").text(description); $(".js-view-count-work_4559902").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_4559902").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="4559902"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3243" rel="nofollow" href="https://www.academia.edu/Documents/in/Nonparametric_Statistics">Nonparametric Statistics</a>, <script data-card-contents-for-ri="3243" type="text/json">{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="14292" rel="nofollow" href="https://www.academia.edu/Documents/in/Oxidative_Stress">Oxidative Stress</a>, <script data-card-contents-for-ri="14292" type="text/json">{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="33069" rel="nofollow" href="https://www.academia.edu/Documents/in/Probability">Probability</a>, <script data-card-contents-for-ri="33069" type="text/json">{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="66325" rel="nofollow" href="https://www.academia.edu/Documents/in/Heparin">Heparin</a><script data-card-contents-for-ri="66325" type="text/json">{"id":66325,"name":"Heparin","url":"https://www.academia.edu/Documents/in/Heparin?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=4559902]'), work: {"id":4559902,"title":"Citrate anticoagulation abolishes degranulation of polymorphonuclear cells and platelets and reduces oxidative stress during haemodialysis","created_at":"2013-09-23T01:16:03.821-07:00","url":"https://www.academia.edu/4559902/Citrate_anticoagulation_abolishes_degranulation_of_polymorphonuclear_cells_and_platelets_and_reduces_oxidative_stress_during_haemodialysis?f_ri=244814","dom_id":"work_4559902","summary":"Background. During haemodialysis (HD), polymorphonuclear cells (PMNs) and platelets are activated and release various granule products, including myeloperoxidase (MPO) and platelet factor 4 (PF4). MPO triggers the generation of reactive oxygen species, leading to irreversible protein, carbohydrate and lipid modification. PF4 probably also contributes to oxidative stress. As previously shown, HD-induced PMN degranulation is almost completely abolished during citrate anticoagulation, most probably due to its calcium chelation ability. Methods. In the present study, apart from HDinduced PMN and platelet degranulation, oxidative stress was analysed during three modes of anticoagulation. Heparin, dalteparin and citrate (HD hep , HD dal and HD cit ) were compared in a randomized, crossover fashion in eight chronic HD patients. Multiple blood samples were taken during the third HD session of each modality, from both the afferent and efferent line. Besides the degranulation markers MPO and PF4, various markers of oxidative stress were measured, including oxidized low-density lipoprotein (ox-LDL), malondialdehyde (MDA) and carboxymethyllysine (CML). Results. During HD hep and HD dal , marked degranulation was observed shortly after the start of HD. In contrast, during HD cit , PF4 and MPO levels remained unaltered, suggesting no release at all. After 1 week of HD cit , ox-LDL levels were markedly reduced [median 26% (3-65%), P ¼ 0.01], if compared with HD hep and HD dal . As regards MDA and CML, no differences were found.","downloadable_attachments":[{"id":31937260,"asset_id":4559902,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5701984,"first_name":"Marianne","last_name":"Schoorl","domain_name":"independent","page_name":"MarianneSchoorl","display_name":"Marianne Schoorl","profile_url":"https://independent.academia.edu/MarianneSchoorl?f_ri=244814","photo":"https://0.academia-photos.com/5701984/2476159/2876684/s65_marianne.schoorl.jpg"}],"research_interests":[{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=244814","nofollow":true},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=244814","nofollow":true},{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability?f_ri=244814","nofollow":true},{"id":66325,"name":"Heparin","url":"https://www.academia.edu/Documents/in/Heparin?f_ri=244814","nofollow":true},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=244814"},{"id":103298,"name":"Blood sampling","url":"https://www.academia.edu/Documents/in/Blood_sampling?f_ri=244814"},{"id":172673,"name":"Haemodialysis","url":"https://www.academia.edu/Documents/in/Haemodialysis?f_ri=244814"},{"id":189949,"name":"Anticoagulants","url":"https://www.academia.edu/Documents/in/Anticoagulants?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814"},{"id":295260,"name":"Neutrophils","url":"https://www.academia.edu/Documents/in/Neutrophils?f_ri=244814"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=244814"},{"id":1000427,"name":"Reference Values","url":"https://www.academia.edu/Documents/in/Reference_Values?f_ri=244814"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure?f_ri=244814"},{"id":1146830,"name":"Cross-Over Studies","url":"https://www.academia.edu/Documents/in/Cross-Over_Studies?f_ri=244814"},{"id":1401310,"name":"Myeloperoxidase","url":"https://www.academia.edu/Documents/in/Myeloperoxidase?f_ri=244814"},{"id":1446339,"name":"Malondialdehyde","url":"https://www.academia.edu/Documents/in/Malondialdehyde?f_ri=244814"},{"id":1611680,"name":"Renal Dialysis","url":"https://www.academia.edu/Documents/in/Renal_Dialysis?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24129839" data-work_id="24129839" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24129839/An_emerging_renaissance_in_medical_education">An emerging renaissance in medical education</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList 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Medicine","url":"https://www.academia.edu/Documents/in/General_Internal_Medicine?f_ri=244814","nofollow":true},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_49578030" data-work_id="49578030" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49578030/Recombinant_factor_VIII_Fc_fusion_protein_for_immune_tolerance_induction_in_patients_with_severe_haemophilia_A_with_inhibitors_A_retrospective_analysis">Recombinant factor VIII Fc fusion protein for immune tolerance induction in patients with severe haemophilia A with inhibitors-A retrospective analysis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Aim: Review outcomes of ITI with recombinant factor VIII Fc fusion protein (rFVIIIFc) in patients with severe haemophilia A and high-titre inhibitors. Methods: Multicentre retrospective chart review of severe haemophilia A patients... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49578030" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Aim: Review outcomes of ITI with recombinant factor VIII Fc fusion protein (rFVIIIFc) in patients with severe haemophilia A and high-titre inhibitors. Methods: Multicentre retrospective chart review of severe haemophilia A patients treated with rFVIIIFc for ITI. Results: Of 19 patients, 7 were first-time ITI and 12 were rescue ITI. Of 7 first-time patients, 6 had at least 1 high-risk feature for ITI failure. Four of 7 first-time patients were tolerized in a median of 7.8 months. The remaining 3 patients continue on rFVIIIFc ITI. Of 12 rescue patients, 7 initially achieved a negative Bethesda titre (≤0.6) in a median of 3.3 months, 1 had a decrease in Bethesda titre and continues on rFVIIIFc ITI and 4 have not demonstrated a decrease in Bethesda titre. Of these 4, 3 continue on rFVIIIFc ITI and 1 switched to bypass therapy alone. Two initially responsive patients transitioned to other factors due to recurrence. Overall, 16 of 19 patients remain on rFVIIIFc (prophylaxis or ITI). For those still undergoing ITI, longer follow-up is needed to determine final outcomes. No adverse events reported. Conclusions: Recombinant factor VIII Fc fusion protein demonstrated rapid time to tolerization in high-risk first-time ITI patients. For rescue ITI, rFVIIIFc showed therapeutic benefit in some patients who previously failed ITI with other products. These findings highlight the need to further evaluate the use of rFVIIIFc for ITI. K E Y W O R D S haemophilia A, immune tolerance induction, inhibitor, recombinant factor VIII Fc fusion protein, rescue therapy, retrospective chart review This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49578030" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="02a92a3657eeeb9c9d7cde0b69ee8a25" rel="nofollow" data-download="{"attachment_id":67899494,"asset_id":49578030,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67899494/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51281503" href="https://independent.academia.edu/KLieuw">K. 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Methods: Multicentre retrospective chart review of severe haemophilia A patients treated with rFVIIIFc for ITI. Results: Of 19 patients, 7 were first-time ITI and 12 were rescue ITI. Of 7 first-time patients, 6 had at least 1 high-risk feature for ITI failure. Four of 7 first-time patients were tolerized in a median of 7.8 months. The remaining 3 patients continue on rFVIIIFc ITI. Of 12 rescue patients, 7 initially achieved a negative Bethesda titre (≤0.6) in a median of 3.3 months, 1 had a decrease in Bethesda titre and continues on rFVIIIFc ITI and 4 have not demonstrated a decrease in Bethesda titre. Of these 4, 3 continue on rFVIIIFc ITI and 1 switched to bypass therapy alone. Two initially responsive patients transitioned to other factors due to recurrence. Overall, 16 of 19 patients remain on rFVIIIFc (prophylaxis or ITI). For those still undergoing ITI, longer follow-up is needed to determine final outcomes. No adverse events reported. Conclusions: Recombinant factor VIII Fc fusion protein demonstrated rapid time to tolerization in high-risk first-time ITI patients. For rescue ITI, rFVIIIFc showed therapeutic benefit in some patients who previously failed ITI with other products. These findings highlight the need to further evaluate the use of rFVIIIFc for ITI. K E Y W O R D S haemophilia A, immune tolerance induction, inhibitor, recombinant factor VIII Fc fusion protein, rescue therapy, retrospective chart review This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.","downloadable_attachments":[{"id":67899494,"asset_id":49578030,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51281503,"first_name":"K.","last_name":"Lieuw","domain_name":"independent","page_name":"KLieuw","display_name":"K. Lieuw","profile_url":"https://independent.academia.edu/KLieuw?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":52588,"name":"Haemophilia","url":"https://www.academia.edu/Documents/in/Haemophilia?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66442358" data-work_id="66442358" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66442358/REVIEW_ARTICLE_Mid_urethral_synthetic_slings_for_female_stress_urinary_incontinence">REVIEW ARTICLE: Mid-urethral synthetic slings for female stress urinary incontinence</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Mid-urethral synthetic slings (MUSS) have grown in acceptance and popularity to gain a foremost position in stress urinary incontinence (SUI) surgery. • There are numerous studies that provide a large amount of Level 1 and 2 evidence that... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_66442358" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Mid-urethral synthetic slings (MUSS) have grown in acceptance and popularity to gain a foremost position in stress urinary incontinence (SUI) surgery. • There are numerous studies that provide a large amount of Level 1 and 2 evidence that support the concept of a sling placed at the level of the mid-urethra. • Long-term follow-up has been published for the original tension-free vaginal tape (TVT) procedure with the most recent publication providing Level 2 evidence with mean follow-up of 11.5 years of 69/91 (77%) of patients from the original series. There was objective cure was in 90% of women and 77% considered themselves subjectively cured, based on the Patient Global Impression of Improvement. • Level 1 evidence with long-term follow-up has been provided comparing colposuspension to TVT at 2 and 5 years. At 5 years for the primary efficacy variable of a negative 1 h stress pad test, there was no difference in success (81% vs 90%). • Two recent meta-analyses provide Level 1 evidence comparing outcomes for retropubic vs transobturator MUSS. One included 18 studies, randomized and cohort: cohort studies had a 12.3% failure rate for transobturator and 13.7% failure for the retropubic approach, randomized studies showed 5.7% failure in the transobturator vs 7.8% in the retropubic group. The other meta-analysis included 11 studies published 2008-2009, which found that the shortterm cure rate was borderline inferior for the transobturator tape group (odds ratio 0.62; 95% confidence interval 0.37-1.00), nearly reaching statistical significance (P = 0.05). • This review details further comparator evidence and evidence for use in specific patient groups (elderly, obese, intrinsic sphincter deficiency, mixed UI).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66442358" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="942bc66cb548e8e47b586e1a2741a8a1" rel="nofollow" data-download="{"attachment_id":77631910,"asset_id":66442358,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77631910/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47238985" href="https://independent.academia.edu/EvaFong">Eva Fong</a><script data-card-contents-for-user="47238985" type="text/json">{"id":47238985,"first_name":"Eva","last_name":"Fong","domain_name":"independent","page_name":"EvaFong","display_name":"Eva Fong","profile_url":"https://independent.academia.edu/EvaFong?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_66442358 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66442358"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66442358, container: ".js-paper-rank-work_66442358", }); });</script></li><li class="js-percentile-work_66442358 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66442358; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_66442358"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_66442358 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="66442358"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66442358; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66442358]").text(description); $(".js-view-count-work_66442358").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_66442358").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66442358"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3382525" rel="nofollow" href="https://www.academia.edu/Documents/in/Suburethral_slings">Suburethral slings</a><script data-card-contents-for-ri="3382525" type="text/json">{"id":3382525,"name":"Suburethral slings","url":"https://www.academia.edu/Documents/in/Suburethral_slings?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66442358]'), work: {"id":66442358,"title":"REVIEW ARTICLE: Mid-urethral synthetic slings for female stress urinary incontinence","created_at":"2021-12-29T13:55:43.529-08:00","url":"https://www.academia.edu/66442358/REVIEW_ARTICLE_Mid_urethral_synthetic_slings_for_female_stress_urinary_incontinence?f_ri=244814","dom_id":"work_66442358","summary":"Mid-urethral synthetic slings (MUSS) have grown in acceptance and popularity to gain a foremost position in stress urinary incontinence (SUI) surgery. • There are numerous studies that provide a large amount of Level 1 and 2 evidence that support the concept of a sling placed at the level of the mid-urethra. • Long-term follow-up has been published for the original tension-free vaginal tape (TVT) procedure with the most recent publication providing Level 2 evidence with mean follow-up of 11.5 years of 69/91 (77%) of patients from the original series. There was objective cure was in 90% of women and 77% considered themselves subjectively cured, based on the Patient Global Impression of Improvement. • Level 1 evidence with long-term follow-up has been provided comparing colposuspension to TVT at 2 and 5 years. At 5 years for the primary efficacy variable of a negative 1 h stress pad test, there was no difference in success (81% vs 90%). • Two recent meta-analyses provide Level 1 evidence comparing outcomes for retropubic vs transobturator MUSS. One included 18 studies, randomized and cohort: cohort studies had a 12.3% failure rate for transobturator and 13.7% failure for the retropubic approach, randomized studies showed 5.7% failure in the transobturator vs 7.8% in the retropubic group. The other meta-analysis included 11 studies published 2008-2009, which found that the shortterm cure rate was borderline inferior for the transobturator tape group (odds ratio 0.62; 95% confidence interval 0.37-1.00), nearly reaching statistical significance (P = 0.05). • This review details further comparator evidence and evidence for use in specific patient groups (elderly, obese, intrinsic sphincter deficiency, mixed UI).","downloadable_attachments":[{"id":77631910,"asset_id":66442358,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47238985,"first_name":"Eva","last_name":"Fong","domain_name":"independent","page_name":"EvaFong","display_name":"Eva Fong","profile_url":"https://independent.academia.edu/EvaFong?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=244814","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":3382525,"name":"Suburethral slings","url":"https://www.academia.edu/Documents/in/Suburethral_slings?f_ri=244814","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21993975" data-work_id="21993975" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21993975/ETFDH_mutations_CoQ10_levels_and_respiratory_chain_activities_in_patients_with_riboflavin_responsive_multiple_acyl_CoA_dehydrogenase_deficiency">ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Multiple acyl-CoA dehydrogenase deficiency CoQ 10 deficiency Riboflavin Electron transfer flavoprotein ubiquinone oxidoreductase a b s t r a c t Multiple acyl-CoA dehydrogenase deficiency (MADD) is a metabolic disorder due to dysfunction... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21993975" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Multiple acyl-CoA dehydrogenase deficiency CoQ 10 deficiency Riboflavin Electron transfer flavoprotein ubiquinone oxidoreductase a b s t r a c t Multiple acyl-CoA dehydrogenase deficiency (MADD) is a metabolic disorder due to dysfunction of electron transfer flavoprotein (ETF) or ETF-ubiquinone oxidoreductase (ETF-QO). Mutations in ETFDH, encoding ETF-QO have been associated with both riboflavin-responsive and non-responsive MADD as well as a myopathic form of CoQ 10 deficiency, although pathomechanisms responsible for these different phenotypes are not well-defined. We performed mutation analysis in four Taiwanese MADD patients. Three novel ETFDH mutations were identified in four patients and all harbored the p.A84T mutation. Muscle CoQ 10 levels and respiratory chain activities measured in two patients were normal. Three patients improved on riboflavin together with carnitine. Our results show that not all MADD patients have CoQ 10 deficiency. Based upon our data, riboflavin and carnitine may be the first-line treatment for MADD.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21993975" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ab4f16045b353b397fdcc180c97cb60e" rel="nofollow" data-download="{"attachment_id":42699352,"asset_id":21993975,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42699352/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43250037" href="https://independent.academia.edu/IchizoNishino">Ichizo Nishino</a><script data-card-contents-for-user="43250037" type="text/json">{"id":43250037,"first_name":"Ichizo","last_name":"Nishino","domain_name":"independent","page_name":"IchizoNishino","display_name":"Ichizo Nishino","profile_url":"https://independent.academia.edu/IchizoNishino?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21993975 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21993975"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21993975, container: ".js-paper-rank-work_21993975", }); });</script></li><li class="js-percentile-work_21993975 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21993975; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21993975"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21993975 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21993975"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21993975; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21993975]").text(description); $(".js-view-count-work_21993975").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21993975").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21993975"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4228" rel="nofollow" href="https://www.academia.edu/Documents/in/Skeletal_muscle_biology">Skeletal muscle biology</a>, <script data-card-contents-for-ri="4228" type="text/json">{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="36213" rel="nofollow" href="https://www.academia.edu/Documents/in/Energy_Metabolism">Energy Metabolism</a>, <script data-card-contents-for-ri="36213" type="text/json">{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="74780" rel="nofollow" href="https://www.academia.edu/Documents/in/Mutation">Mutation</a><script data-card-contents-for-ri="74780" type="text/json">{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21993975]'), work: {"id":21993975,"title":"ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency","created_at":"2016-02-15T04:28:18.623-08:00","url":"https://www.academia.edu/21993975/ETFDH_mutations_CoQ10_levels_and_respiratory_chain_activities_in_patients_with_riboflavin_responsive_multiple_acyl_CoA_dehydrogenase_deficiency?f_ri=244814","dom_id":"work_21993975","summary":"Multiple acyl-CoA dehydrogenase deficiency CoQ 10 deficiency Riboflavin Electron transfer flavoprotein ubiquinone oxidoreductase a b s t r a c t Multiple acyl-CoA dehydrogenase deficiency (MADD) is a metabolic disorder due to dysfunction of electron transfer flavoprotein (ETF) or ETF-ubiquinone oxidoreductase (ETF-QO). Mutations in ETFDH, encoding ETF-QO have been associated with both riboflavin-responsive and non-responsive MADD as well as a myopathic form of CoQ 10 deficiency, although pathomechanisms responsible for these different phenotypes are not well-defined. We performed mutation analysis in four Taiwanese MADD patients. Three novel ETFDH mutations were identified in four patients and all harbored the p.A84T mutation. Muscle CoQ 10 levels and respiratory chain activities measured in two patients were normal. Three patients improved on riboflavin together with carnitine. Our results show that not all MADD patients have CoQ 10 deficiency. Based upon our data, riboflavin and carnitine may be the first-line treatment for MADD.","downloadable_attachments":[{"id":42699352,"asset_id":21993975,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43250037,"first_name":"Ichizo","last_name":"Nishino","domain_name":"independent","page_name":"IchizoNishino","display_name":"Ichizo Nishino","profile_url":"https://independent.academia.edu/IchizoNishino?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=244814","nofollow":true},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism?f_ri=244814","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=244814","nofollow":true},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=244814","nofollow":true},{"id":83359,"name":"Electron Transfer","url":"https://www.academia.edu/Documents/in/Electron_Transfer?f_ri=244814"},{"id":94451,"name":"Taiwan","url":"https://www.academia.edu/Documents/in/Taiwan?f_ri=244814"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=244814"},{"id":159283,"name":"Mitochondrial Respiratory Chain","url":"https://www.academia.edu/Documents/in/Mitochondrial_Respiratory_Chain?f_ri=244814"},{"id":186094,"name":"Electron Transport","url":"https://www.academia.edu/Documents/in/Electron_Transport?f_ri=244814"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":295453,"name":"L-carnitine","url":"https://www.academia.edu/Documents/in/L-carnitine?f_ri=244814"},{"id":407854,"name":"Neuromuscular Disorders","url":"https://www.academia.edu/Documents/in/Neuromuscular_Disorders?f_ri=244814"},{"id":561987,"name":"Asian Continental Ancestry Group","url":"https://www.academia.edu/Documents/in/Asian_Continental_Ancestry_Group?f_ri=244814"},{"id":900002,"name":"Metabolic Disorder","url":"https://www.academia.edu/Documents/in/Metabolic_Disorder?f_ri=244814"},{"id":1155960,"name":"Neuromuscular","url":"https://www.academia.edu/Documents/in/Neuromuscular?f_ri=244814"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=244814"},{"id":1489115,"name":"Age of Onset","url":"https://www.academia.edu/Documents/in/Age_of_Onset?f_ri=244814"},{"id":1573017,"name":"Riboflavin","url":"https://www.academia.edu/Documents/in/Riboflavin?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61124960" data-work_id="61124960" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61124960/Distinct_patterns_of_APP_processing_in_the_CNS_in_autosomal_dominant_and_sporadic_Alzheimer_disease">Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes. Studies from families with ADAD have been critical to support the amyloid cascade... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61124960" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes. Studies from families with ADAD have been critical to support the amyloid cascade hypothesis of Alzheimer disease (AD), the basis for the current development of amyloid-based disease-modifying therapies in sporadic AD (SAD). However, whether the pathological changes in APP processing in the CNS in ADAD are similar to those observed in SAD remains unclear. In this study, we measured b-site APP-cleaving enzyme (BACE) protein levels and activity, APP and APP C-terminal fragments in brain samples from subjects with ADAD carrying APP or PSEN1 mutations (n = 18), patients with SAD (n = 27) and agematched controls (n = 22). We also measured sAPPb and BACE protein levels, as well as BACE activity, in CSF from individuals carrying PSEN1 mutations (10 mutation carriers and 7 non-carrier controls), patients with SAD (n = 32) and age-matched controls (n = 11). We found that in the brain, the pattern in ADAD was characterized by an increase in APP b-C-terminal fragment (b-CTF) levels despite no changes in BACE protein levels or activity. In contrast, the pattern in SAD in the brain was mainly characterized by an increase in BACE levels and activity, with less APP b-CTF accumulation than ADAD. In the CSF, no differences were found between groups in BACE activity or expression or sAPPb levels. Taken together, these data suggest that the physiopathological events underlying the chronic Ab production/clearance imbalance in SAD and ADAD are different. These differences should be considered in the design of intervention trials in AD.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61124960" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3f3cda966b097717ea598902428263d0" rel="nofollow" data-download="{"attachment_id":74274665,"asset_id":61124960,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74274665/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="149928559" href="https://noente.academia.edu/DanielAlcolea">Daniel Alcolea</a><script data-card-contents-for-user="149928559" type="text/json">{"id":149928559,"first_name":"Daniel","last_name":"Alcolea","domain_name":"noente","page_name":"DanielAlcolea","display_name":"Daniel Alcolea","profile_url":"https://noente.academia.edu/DanielAlcolea?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61124960 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61124960"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61124960, container: ".js-paper-rank-work_61124960", }); });</script></li><li class="js-percentile-work_61124960 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61124960; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_61124960"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_61124960 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="61124960"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61124960; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61124960]").text(description); $(".js-view-count-work_61124960").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61124960").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61124960"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12071" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunohistochemistry">Immunohistochemistry</a>, <script data-card-contents-for-ri="12071" type="text/json">{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37834" rel="nofollow" href="https://www.academia.edu/Documents/in/Western_blotting">Western blotting</a>, <script data-card-contents-for-ri="37834" type="text/json">{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="74780" rel="nofollow" href="https://www.academia.edu/Documents/in/Mutation">Mutation</a>, <script data-card-contents-for-ri="74780" type="text/json">{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="147195" rel="nofollow" href="https://www.academia.edu/Documents/in/Central_Nervous_System">Central Nervous System</a><script data-card-contents-for-ri="147195" type="text/json">{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61124960]'), work: {"id":61124960,"title":"Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease","created_at":"2021-11-06T10:51:20.465-07:00","url":"https://www.academia.edu/61124960/Distinct_patterns_of_APP_processing_in_the_CNS_in_autosomal_dominant_and_sporadic_Alzheimer_disease?f_ri=244814","dom_id":"work_61124960","summary":"Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes. Studies from families with ADAD have been critical to support the amyloid cascade hypothesis of Alzheimer disease (AD), the basis for the current development of amyloid-based disease-modifying therapies in sporadic AD (SAD). However, whether the pathological changes in APP processing in the CNS in ADAD are similar to those observed in SAD remains unclear. In this study, we measured b-site APP-cleaving enzyme (BACE) protein levels and activity, APP and APP C-terminal fragments in brain samples from subjects with ADAD carrying APP or PSEN1 mutations (n = 18), patients with SAD (n = 27) and agematched controls (n = 22). We also measured sAPPb and BACE protein levels, as well as BACE activity, in CSF from individuals carrying PSEN1 mutations (10 mutation carriers and 7 non-carrier controls), patients with SAD (n = 32) and age-matched controls (n = 11). We found that in the brain, the pattern in ADAD was characterized by an increase in APP b-C-terminal fragment (b-CTF) levels despite no changes in BACE protein levels or activity. In contrast, the pattern in SAD in the brain was mainly characterized by an increase in BACE levels and activity, with less APP b-CTF accumulation than ADAD. In the CSF, no differences were found between groups in BACE activity or expression or sAPPb levels. Taken together, these data suggest that the physiopathological events underlying the chronic Ab production/clearance imbalance in SAD and ADAD are different. These differences should be considered in the design of intervention trials in AD.","downloadable_attachments":[{"id":74274665,"asset_id":61124960,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":149928559,"first_name":"Daniel","last_name":"Alcolea","domain_name":"noente","page_name":"DanielAlcolea","display_name":"Daniel Alcolea","profile_url":"https://noente.academia.edu/DanielAlcolea?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=244814","nofollow":true},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=244814","nofollow":true},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=244814","nofollow":true},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814"},{"id":452440,"name":"Presenilin-2","url":"https://www.academia.edu/Documents/in/Presenilin-2?f_ri=244814"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease?f_ri=244814"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=244814"},{"id":2028686,"name":"Amyloid Beta Precursor Protein","url":"https://www.academia.edu/Documents/in/Amyloid_Beta_Precursor_Protein?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23374555 coauthored" data-work_id="23374555" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23374555/Relative_value_units_and_payer_mix_analysis_of_facial_trauma_coverage_at_a_level_1_trauma_center_Is_the_current_model_sustainable">Relative value units and payer mix analysis of facial trauma coverage at a level 1 trauma center: Is the current model sustainable?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose. We aimed to approximate the annual clinical work that is performed during facial trauma coverage and analyze the economic incentives for subspecialty surgeons providing the coverage. Methods. A retrospective, clinical... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23374555" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose. We aimed to approximate the annual clinical work that is performed during facial trauma coverage and analyze the economic incentives for subspecialty surgeons providing the coverage. Methods. A retrospective, clinical productivity data analysis of 6 consecutive years of facial trauma coverage at an American College of Surgeons-verified Level I trauma center was performed by the use of a trauma database and relative value unit (RVU) data. A payer mix analysis also was completed. SPSS V19 was used for analysis. Results. Between 2006 and 2011, 526 patients were treated for facial injuries. The annual nonoperative RVUs ranged from 371 to 539, whereas the annual operative RVUs range was 235-426. Trend analysis displayed that most of the annual RVUs were nonoperative until the year 2011, when the operative RVUs surpassed the nonoperative. Payer mix analysis revealed that commercial insurance coverage was the most common (range 21-54%, median 41%) followed by self-pay coverage (18-32%, median 29%). This finding was a consistent phenomenon except in the year 2009, when self-pay covered the majority of the RVUs (32%). Nasal bone fractures (24%) and mandibular fractures (16%) were the two most common diagnoses. Open reduction and internal fixation of mandibular fractures (17%), open reduction and internal fixation orbital bone fractures (15%), and complex facial repair (12%) constituted the most common operative procedures. Facial trauma consultations were obtained 22% (16-24%) of covered days. The percent of days requiring emergency procedures was (0.5-1%). Conclusion. The infrequency of subspecialty consultations and operative interventions, and significant payer mix differences between facial trauma patients relative to the current ambulatory surgery population of the covering subspecialties poses economical challenges for both the hospitals and providers that use the traditional coverage models. (Surgery 2014; From the Brigham and Women'</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23374555" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e83b91358ba16fb0abbc62a62b023a25" rel="nofollow" data-download="{"attachment_id":43825956,"asset_id":23374555,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43825956/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45240964" href="https://independent.academia.edu/ReginaldBaugh">Reginald Baugh</a><script data-card-contents-for-user="45240964" type="text/json">{"id":45240964,"first_name":"Reginald","last_name":"Baugh","domain_name":"independent","page_name":"ReginaldBaugh","display_name":"Reginald Baugh","profile_url":"https://independent.academia.edu/ReginaldBaugh?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-23374555">+1</span><div class="hidden js-additional-users-23374555"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/MalloryWilliams2">Mallory Williams</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-23374555'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-23374555').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_23374555 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23374555"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23374555, container: ".js-paper-rank-work_23374555", }); });</script></li><li class="js-percentile-work_23374555 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 23374555; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_23374555"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_23374555 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="23374555"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 23374555; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=23374555]").text(description); $(".js-view-count-work_23374555").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23374555").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23374555"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="647" rel="nofollow" href="https://www.academia.edu/Documents/in/Surgery">Surgery</a>, <script data-card-contents-for-ri="647" type="text/json">{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="652" rel="nofollow" href="https://www.academia.edu/Documents/in/Traumatology">Traumatology</a>, <script data-card-contents-for-ri="652" type="text/json">{"id":652,"name":"Traumatology","url":"https://www.academia.edu/Documents/in/Traumatology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="219927" rel="nofollow" href="https://www.academia.edu/Documents/in/Efficiency">Efficiency</a>, <script data-card-contents-for-ri="219927" type="text/json">{"id":219927,"name":"Efficiency","url":"https://www.academia.edu/Documents/in/Efficiency?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23374555]'), work: {"id":23374555,"title":"Relative value units and payer mix analysis of facial trauma coverage at a level 1 trauma center: Is the current model sustainable?","created_at":"2016-03-17T10:25:00.765-07:00","url":"https://www.academia.edu/23374555/Relative_value_units_and_payer_mix_analysis_of_facial_trauma_coverage_at_a_level_1_trauma_center_Is_the_current_model_sustainable?f_ri=244814","dom_id":"work_23374555","summary":"Purpose. We aimed to approximate the annual clinical work that is performed during facial trauma coverage and analyze the economic incentives for subspecialty surgeons providing the coverage. Methods. A retrospective, clinical productivity data analysis of 6 consecutive years of facial trauma coverage at an American College of Surgeons-verified Level I trauma center was performed by the use of a trauma database and relative value unit (RVU) data. A payer mix analysis also was completed. SPSS V19 was used for analysis. Results. Between 2006 and 2011, 526 patients were treated for facial injuries. The annual nonoperative RVUs ranged from 371 to 539, whereas the annual operative RVUs range was 235-426. Trend analysis displayed that most of the annual RVUs were nonoperative until the year 2011, when the operative RVUs surpassed the nonoperative. Payer mix analysis revealed that commercial insurance coverage was the most common (range 21-54%, median 41%) followed by self-pay coverage (18-32%, median 29%). This finding was a consistent phenomenon except in the year 2009, when self-pay covered the majority of the RVUs (32%). Nasal bone fractures (24%) and mandibular fractures (16%) were the two most common diagnoses. Open reduction and internal fixation of mandibular fractures (17%), open reduction and internal fixation orbital bone fractures (15%), and complex facial repair (12%) constituted the most common operative procedures. Facial trauma consultations were obtained 22% (16-24%) of covered days. The percent of days requiring emergency procedures was (0.5-1%). Conclusion. The infrequency of subspecialty consultations and operative interventions, and significant payer mix differences between facial trauma patients relative to the current ambulatory surgery population of the covering subspecialties poses economical challenges for both the hospitals and providers that use the traditional coverage models. (Surgery 2014; From the Brigham and Women'","downloadable_attachments":[{"id":43825956,"asset_id":23374555,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45240964,"first_name":"Reginald","last_name":"Baugh","domain_name":"independent","page_name":"ReginaldBaugh","display_name":"Reginald Baugh","profile_url":"https://independent.academia.edu/ReginaldBaugh?f_ri=244814","photo":"/images/s65_no_pic.png"},{"id":48152863,"first_name":"Mallory","last_name":"Williams","domain_name":"independent","page_name":"MalloryWilliams2","display_name":"Mallory Williams","profile_url":"https://independent.academia.edu/MalloryWilliams2?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=244814","nofollow":true},{"id":652,"name":"Traumatology","url":"https://www.academia.edu/Documents/in/Traumatology?f_ri=244814","nofollow":true},{"id":219927,"name":"Efficiency","url":"https://www.academia.edu/Documents/in/Efficiency?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17686473" data-work_id="17686473" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17686473/Perception_of_family_functioning_and_depressive_symptomatology_in_individuals_with_anorexia_nervosa_or_bulimia_nervosa">Perception of family functioning and depressive symptomatology in individuals with anorexia nervosa or bulimia nervosa</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This study investigated the relationship between the perception of family functioning and depressive symptomatology in individuals with eating disorders (EDs). Subjects were evaluated by diagnostic clinical interview using DSM-III-R... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17686473" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This study investigated the relationship between the perception of family functioning and depressive symptomatology in individuals with eating disorders (EDs). Subjects were evaluated by diagnostic clinical interview using DSM-III-R criteria for EDs, the Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-L), and two self-report measures, the Beck Depression Inventory (BDI) and the Family Assessment Device (FAD). A significant association was found between self-reported depressive symptomatology and perceived poor family functioning. Subjects with bulimia nervosa (BN) reported a significantly more dysfunctional family background than subjects with anorexia nervosa (AN). In our sample, the presence of self-reported depressive symptomatology was a more powerful predictive variable for perceived family dysfunction than the diagnosis of affective disorder. Also, the diagnosis of BN was a more consistent predictor of dysfunctional family interaction than the diagnosis of affective disorder. Depressive symptoms and EDs seem to play different roles in the way in which they contribute to dysfunctional family patterns.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17686473" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="18b5d88b145f245e7f5f4844a94ebbc3" rel="nofollow" data-download="{"attachment_id":42238516,"asset_id":17686473,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42238516/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33673953" href="https://pfizer.academia.edu/FrancineMandel">Francine S P Mandel</a><script data-card-contents-for-user="33673953" type="text/json">{"id":33673953,"first_name":"Francine","last_name":"Mandel","domain_name":"pfizer","page_name":"FrancineMandel","display_name":"Francine S P Mandel","profile_url":"https://pfizer.academia.edu/FrancineMandel?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17686473 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17686473"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17686473, container: ".js-paper-rank-work_17686473", }); });</script></li><li class="js-percentile-work_17686473 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17686473; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_17686473"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_17686473 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="17686473"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17686473; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17686473]").text(description); $(".js-view-count-work_17686473").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17686473").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17686473"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3217" rel="nofollow" href="https://www.academia.edu/Documents/in/Depression">Depression</a>, <script data-card-contents-for-ri="3217" type="text/json">{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6574" rel="nofollow" href="https://www.academia.edu/Documents/in/Family">Family</a>, <script data-card-contents-for-ri="6574" type="text/json">{"id":6574,"name":"Family","url":"https://www.academia.edu/Documents/in/Family?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="33242" rel="nofollow" href="https://www.academia.edu/Documents/in/Anorexia_Nervosa">Anorexia Nervosa</a><script data-card-contents-for-ri="33242" type="text/json">{"id":33242,"name":"Anorexia Nervosa","url":"https://www.academia.edu/Documents/in/Anorexia_Nervosa?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17686473]'), work: {"id":17686473,"title":"Perception of family functioning and depressive symptomatology in individuals with anorexia nervosa or bulimia nervosa","created_at":"2015-11-03T19:55:59.688-08:00","url":"https://www.academia.edu/17686473/Perception_of_family_functioning_and_depressive_symptomatology_in_individuals_with_anorexia_nervosa_or_bulimia_nervosa?f_ri=244814","dom_id":"work_17686473","summary":"This study investigated the relationship between the perception of family functioning and depressive symptomatology in individuals with eating disorders (EDs). Subjects were evaluated by diagnostic clinical interview using DSM-III-R criteria for EDs, the Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-L), and two self-report measures, the Beck Depression Inventory (BDI) and the Family Assessment Device (FAD). A significant association was found between self-reported depressive symptomatology and perceived poor family functioning. Subjects with bulimia nervosa (BN) reported a significantly more dysfunctional family background than subjects with anorexia nervosa (AN). In our sample, the presence of self-reported depressive symptomatology was a more powerful predictive variable for perceived family dysfunction than the diagnosis of affective disorder. Also, the diagnosis of BN was a more consistent predictor of dysfunctional family interaction than the diagnosis of affective disorder. Depressive symptoms and EDs seem to play different roles in the way in which they contribute to dysfunctional family patterns.","downloadable_attachments":[{"id":42238516,"asset_id":17686473,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33673953,"first_name":"Francine","last_name":"Mandel","domain_name":"pfizer","page_name":"FrancineMandel","display_name":"Francine S P Mandel","profile_url":"https://pfizer.academia.edu/FrancineMandel?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=244814","nofollow":true},{"id":6574,"name":"Family","url":"https://www.academia.edu/Documents/in/Family?f_ri=244814","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=244814","nofollow":true},{"id":33242,"name":"Anorexia Nervosa","url":"https://www.academia.edu/Documents/in/Anorexia_Nervosa?f_ri=244814","nofollow":true},{"id":33243,"name":"Bulimia Nervosa","url":"https://www.academia.edu/Documents/in/Bulimia_Nervosa?f_ri=244814"},{"id":49419,"name":"Problem Solving","url":"https://www.academia.edu/Documents/in/Problem_Solving?f_ri=244814"},{"id":159017,"name":"Family Functioning","url":"https://www.academia.edu/Documents/in/Family_Functioning?f_ri=244814"},{"id":195969,"name":"Beck Depression Inventory","url":"https://www.academia.edu/Documents/in/Beck_Depression_Inventory?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":284201,"name":"Mood Disorders","url":"https://www.academia.edu/Documents/in/Mood_Disorders?f_ri=244814"},{"id":339623,"name":"Comprehensive","url":"https://www.academia.edu/Documents/in/Comprehensive?f_ri=244814"},{"id":578336,"name":"Eating Disorder","url":"https://www.academia.edu/Documents/in/Eating_Disorder?f_ri=244814"},{"id":706975,"name":"Depressive Symptoms","url":"https://www.academia.edu/Documents/in/Depressive_Symptoms?f_ri=244814"},{"id":962636,"name":"Bulimia","url":"https://www.academia.edu/Documents/in/Bulimia?f_ri=244814"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=244814"},{"id":1355489,"name":"Affective Disorder","url":"https://www.academia.edu/Documents/in/Affective_Disorder?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26090734" data-work_id="26090734" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26090734/Angiotensinogen_gene_polymorphisms_Relationship_to_blood_pressure_response_to_antihypertensive_treatment">Angiotensinogen gene polymorphisms: Relationship to blood pressure response to antihypertensive treatment</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The renin-angiotensin-aldosterone system (RAAS) is important for the development of hypertension, and several antihypertensive drugs target this system. Our aim was to determine whether specific single nucleotide polymorphisms (SNPs) in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_26090734" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The renin-angiotensin-aldosterone system (RAAS) is important for the development of hypertension, and several antihypertensive drugs target this system. Our aim was to determine whether specific single nucleotide polymorphisms (SNPs) in RAAS genes were related to the blood pressure (BP) lowering effect of antihypertensive treatment. Methods: Patients with mild to moderate primary hypertension and left ventricular hypertrophy were randomized in a double-blind fashion to treatment with either the angiotensin II type 1 receptor antagonist irbesartan (n ϭ 48) or the ␤ 1 -adrenergic receptor blocker atenolol (n ϭ 49) as monotherapy. A microarray-based minisequencing system was used to genotype 30 SNPs in seven genes in the RAAS. These polymorphisms were related to the antihypertensive response after 12 weeks treatment. Results: The BP reductions were similar in the atenolol and the irbesartan groups. Presence of the angiotensinogen (AGT) -6A allele or the AGT 235T allele were both associated with the most pronounced systolic BP response to atenolol treatment (P ϭ .001 when -6 AAϩAG was compared with GG and P ϭ .008 for presence of the 235T variant compared with 235 MM).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26090734" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="35db9bb710fb113c3846e3e73c324f96" rel="nofollow" data-download="{"attachment_id":46443725,"asset_id":26090734,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46443725/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="49791239" href="https://independent.academia.edu/LisaKurland">Lisa Kurland</a><script data-card-contents-for-user="49791239" type="text/json">{"id":49791239,"first_name":"Lisa","last_name":"Kurland","domain_name":"independent","page_name":"LisaKurland","display_name":"Lisa Kurland","profile_url":"https://independent.academia.edu/LisaKurland?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_26090734 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="26090734"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 26090734, container: ".js-paper-rank-work_26090734", }); });</script></li><li class="js-percentile-work_26090734 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26090734; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_26090734"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_26090734 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="26090734"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26090734; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26090734]").text(description); $(".js-view-count-work_26090734").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_26090734").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="26090734"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71399" rel="nofollow" href="https://www.academia.edu/Documents/in/Hypertension">Hypertension</a>, <script data-card-contents-for-ri="71399" type="text/json">{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="88321" rel="nofollow" href="https://www.academia.edu/Documents/in/Blood_Pressure">Blood Pressure</a>, <script data-card-contents-for-ri="88321" type="text/json">{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="90002" rel="nofollow" href="https://www.academia.edu/Documents/in/Renin_Angiotensin_Aldosterone_System">Renin Angiotensin Aldosterone System</a><script data-card-contents-for-ri="90002" type="text/json">{"id":90002,"name":"Renin Angiotensin Aldosterone System","url":"https://www.academia.edu/Documents/in/Renin_Angiotensin_Aldosterone_System?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=26090734]'), work: {"id":26090734,"title":"Angiotensinogen gene polymorphisms: Relationship to blood pressure response to antihypertensive treatment","created_at":"2016-06-13T10:44:02.799-07:00","url":"https://www.academia.edu/26090734/Angiotensinogen_gene_polymorphisms_Relationship_to_blood_pressure_response_to_antihypertensive_treatment?f_ri=244814","dom_id":"work_26090734","summary":"The renin-angiotensin-aldosterone system (RAAS) is important for the development of hypertension, and several antihypertensive drugs target this system. Our aim was to determine whether specific single nucleotide polymorphisms (SNPs) in RAAS genes were related to the blood pressure (BP) lowering effect of antihypertensive treatment. Methods: Patients with mild to moderate primary hypertension and left ventricular hypertrophy were randomized in a double-blind fashion to treatment with either the angiotensin II type 1 receptor antagonist irbesartan (n ϭ 48) or the ␤ 1 -adrenergic receptor blocker atenolol (n ϭ 49) as monotherapy. A microarray-based minisequencing system was used to genotype 30 SNPs in seven genes in the RAAS. These polymorphisms were related to the antihypertensive response after 12 weeks treatment. Results: The BP reductions were similar in the atenolol and the irbesartan groups. Presence of the angiotensinogen (AGT) -6A allele or the AGT 235T allele were both associated with the most pronounced systolic BP response to atenolol treatment (P ϭ .001 when -6 AAϩAG was compared with GG and P ϭ .008 for presence of the 235T variant compared with 235 MM).","downloadable_attachments":[{"id":46443725,"asset_id":26090734,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":49791239,"first_name":"Lisa","last_name":"Kurland","domain_name":"independent","page_name":"LisaKurland","display_name":"Lisa Kurland","profile_url":"https://independent.academia.edu/LisaKurland?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=244814","nofollow":true},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=244814","nofollow":true},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=244814","nofollow":true},{"id":90002,"name":"Renin Angiotensin Aldosterone System","url":"https://www.academia.edu/Documents/in/Renin_Angiotensin_Aldosterone_System?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":306990,"name":"Gene Polymorphism","url":"https://www.academia.edu/Documents/in/Gene_Polymorphism?f_ri=244814"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype?f_ri=244814"},{"id":403740,"name":"Single Nucleotide Polymorphism","url":"https://www.academia.edu/Documents/in/Single_Nucleotide_Polymorphism?f_ri=244814"},{"id":1015099,"name":"Drug Targeting","url":"https://www.academia.edu/Documents/in/Drug_Targeting?f_ri=244814"},{"id":1592916,"name":"Drug treatment","url":"https://www.academia.edu/Documents/in/Drug_treatment?f_ri=244814"},{"id":2328374,"name":"Atenolol","url":"https://www.academia.edu/Documents/in/Atenolol?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5491847" data-work_id="5491847" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5491847/Clinical_and_molecular_features_of_mitochondrial_DNA_depletion_syndromes">Clinical and molecular features of mitochondrial DNA depletion syndromes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Mitochondrial DNA depletion syndromes (MDSs) form a group of autosomal recessive disorders characterized by profoundly decreased mitochondrial DNA copy numbers in affected tissues. Three main clinical presentations are known: myopathic,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5491847" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Mitochondrial DNA depletion syndromes (MDSs) form a group of autosomal recessive disorders characterized by profoundly decreased mitochondrial DNA copy numbers in affected tissues. Three main clinical presentations are known: myopathic, encephalomyopathic and hepatocerebral. The first is associated with mutations in thymidine kinase 2 (TK2) and p53-induced ribonucleotide reductase B subunit (RRM2B); the second with mutations in succinate synthase A (SUCLA2) and B (SUCLG1); the third with mutations in Twinkle (PEO1), pol-γA (POLG1), deoxyguanosine kinase (DGUOK) and MPV17 (MPV17). In this work, we review the MDS-associated phenotypes and present our own experience of 32 MDS patients, with the aim of defining the mutation frequency of the known genes, the clinical spectrum of the diseases, and the genotype–phenotype correlations. Five of our patients carried previously unreported mutations in one of the eight MDS genes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5491847" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9d314ecd6e937d950e1183a419804605" rel="nofollow" data-download="{"attachment_id":49272469,"asset_id":5491847,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49272469/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7734703" href="https://mrc.academia.edu/antonellaSpinazzola">antonella Spinazzola</a><script data-card-contents-for-user="7734703" type="text/json">{"id":7734703,"first_name":"antonella","last_name":"Spinazzola","domain_name":"mrc","page_name":"antonellaSpinazzola","display_name":"antonella Spinazzola","profile_url":"https://mrc.academia.edu/antonellaSpinazzola?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_5491847 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5491847"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5491847, container: ".js-paper-rank-work_5491847", }); 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Three main clinical presentations are known: myopathic, encephalomyopathic and hepatocerebral. The first is associated with mutations in thymidine kinase 2 (TK2) and p53-induced ribonucleotide reductase B subunit (RRM2B); the second with mutations in succinate synthase A (SUCLA2) and B (SUCLG1); the third with mutations in Twinkle (PEO1), pol-γA (POLG1), deoxyguanosine kinase (DGUOK) and MPV17 (MPV17). In this work, we review the MDS-associated phenotypes and present our own experience of 32 MDS patients, with the aim of defining the mutation frequency of the known genes, the clinical spectrum of the diseases, and the genotype–phenotype correlations. Five of our patients carried previously unreported mutations in one of the eight MDS genes.","downloadable_attachments":[{"id":49272469,"asset_id":5491847,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":7734703,"first_name":"antonella","last_name":"Spinazzola","domain_name":"mrc","page_name":"antonellaSpinazzola","display_name":"antonella Spinazzola","profile_url":"https://mrc.academia.edu/antonellaSpinazzola?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=244814","nofollow":true},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=244814","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=244814","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=244814","nofollow":true},{"id":63093,"name":"Mitochondrial DNA","url":"https://www.academia.edu/Documents/in/Mitochondrial_DNA?f_ri=244814"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=244814"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver?f_ri=244814"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=244814"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=244814"},{"id":170918,"name":"Electromyography","url":"https://www.academia.edu/Documents/in/Electromyography?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=244814"},{"id":290205,"name":"Mitochondrial Diseases","url":"https://www.academia.edu/Documents/in/Mitochondrial_Diseases?f_ri=244814"},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum?f_ri=244814"},{"id":627622,"name":"Thymidine Kinase","url":"https://www.academia.edu/Documents/in/Thymidine_Kinase?f_ri=244814"},{"id":830071,"name":"Ribonucleotide Reductase","url":"https://www.academia.edu/Documents/in/Ribonucleotide_Reductase?f_ri=244814"},{"id":961812,"name":"Autosomal Recessive","url":"https://www.academia.edu/Documents/in/Autosomal_Recessive?f_ri=244814"},{"id":985062,"name":"Clinical Presentation","url":"https://www.academia.edu/Documents/in/Clinical_Presentation?f_ri=244814"},{"id":1489115,"name":"Age of Onset","url":"https://www.academia.edu/Documents/in/Age_of_Onset?f_ri=244814"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=244814"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22662832" data-work_id="22662832" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22662832/Preemptive_analgesia_in_elective_surgery_in_patients_with_complex_regional_pain_syndrome_A_case_report">Preemptive analgesia in elective surgery in patients with complex regional pain syndrome: A case report</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Comp lex regional pain syndrome (CRPS) can be a complication of injury or surgery or have an obscu re etiology. Special precautions are indicated (i.e., preemptive analgesia) when surgery is required with a patient who has been diagnosed... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22662832" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Comp lex regional pain syndrome (CRPS) can be a complication of injury or surgery or have an obscu re etiology. Special precautions are indicated (i.e., preemptive analgesia) when surgery is required with a patient who has been diagnosed with CRPS. The complex case of a 44-year-old female diagnosed with reflex sympathetic dystrophy (RSD) is discussed, including current treatment options. A brief review of the literature as well as the features of complex regional pain syndrome (CRPS IIRSD and CRPS I//causalgia) are presented.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22662832" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d2338728474a4ff4e9421e0d212884d8" rel="nofollow" data-download="{"attachment_id":43252793,"asset_id":22662832,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43252793/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44252152" href="https://independent.academia.edu/RaczGabor">Gabor Racz</a><script data-card-contents-for-user="44252152" type="text/json">{"id":44252152,"first_name":"Gabor","last_name":"Racz","domain_name":"independent","page_name":"RaczGabor","display_name":"Gabor Racz","profile_url":"https://independent.academia.edu/RaczGabor?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22662832 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22662832"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22662832, container: ".js-paper-rank-work_22662832", }); 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Special precautions are indicated (i.e., preemptive analgesia) when surgery is required with a patient who has been diagnosed with CRPS. The complex case of a 44-year-old female diagnosed with reflex sympathetic dystrophy (RSD) is discussed, including current treatment options. A brief review of the literature as well as the features of complex regional pain syndrome (CRPS IIRSD and CRPS I//causalgia) are presented.","downloadable_attachments":[{"id":43252793,"asset_id":22662832,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44252152,"first_name":"Gabor","last_name":"Racz","domain_name":"independent","page_name":"RaczGabor","display_name":"Gabor Racz","profile_url":"https://independent.academia.edu/RaczGabor?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":40210,"name":"Foot and Ankle Surgery","url":"https://www.academia.edu/Documents/in/Foot_and_Ankle_Surgery?f_ri=244814","nofollow":true},{"id":63886,"name":"Case Report","url":"https://www.academia.edu/Documents/in/Case_Report?f_ri=244814","nofollow":true},{"id":136811,"name":"Analgesia","url":"https://www.academia.edu/Documents/in/Analgesia?f_ri=244814","nofollow":true},{"id":232448,"name":"Complex Regional Pain Syndrome","url":"https://www.academia.edu/Documents/in/Complex_Regional_Pain_Syndrome?f_ri=244814","nofollow":true},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":449523,"name":"Foot","url":"https://www.academia.edu/Documents/in/Foot?f_ri=244814"},{"id":587010,"name":"Foot Diseases","url":"https://www.academia.edu/Documents/in/Foot_Diseases?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21853371" data-work_id="21853371" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" 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data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" 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Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27984081 coauthored" data-work_id="27984081" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27984081/The_Dog_as_an_Animal_Model_for_Intervertebral_Disc_Degeneration">The Dog as an Animal Model for Intervertebral Disc Degeneration?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Study Design. Prospective observational and analytic study. Objective. To investigate whether spontaneous intervertebral disc degeneration (IVDD) occurring in both chondrodystrophic (CD) and nonchondrodystrophic dogs (NCD) can be used as... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27984081" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Study Design. Prospective observational and analytic study. Objective. To investigate whether spontaneous intervertebral disc degeneration (IVDD) occurring in both chondrodystrophic (CD) and nonchondrodystrophic dogs (NCD) can be used as a valid translational model for human IVDD research. Summary of Background Data. Different animal models are used in IVDD research, but in most of these models IVDD is induced manually or chemically rather than occurring spontaneously. Methods. A total of 184 intervertebral discs (IVDs) from 19 dogs of different breeds were used. The extent of IVDD was evaluated by macroscopic grading, histopathology, glycosaminoglycan content, and matrix metalloproteinase 2 activity. Canine data were compared with human IVD data acquired in this study or from the literature. Results. Gross pathology of IVDD in both dog types (CD and NCD) and humans showed many similarities, but the cartilaginous endplates were signifi cantly thicker and the subchondral cortices signifi cantly thinner in humans than in dogs. Notochordal cells were still present in the IVDs of adult NCD but were not seen in the CD breeds or in humans. Signs of degeneration were seen in young dogs of CD breeds ( < 1 year of age), whereas this was only seen in older dogs of NCD breeds (5-7 years of age). The relative glycosaminoglycan content and metalloproteinase 2 activity in canine IVDD were similar to those in humans: metalloproteinase 2 activity increased and glycosaminoglycan content decreased with increasing severity of IVDD. Conclusion. IVDD is similar in humans and dogs. Both CD and NCD breeds may therefore serve as models of spontaneous IVDD for human research. However, as with all animal models, it is important to recognize interspecies differences and, indeed, the intraspecies differences between CD and NCD breeds (early vs. late onset of IVDD, respectively) to develop an optimal canine model of human IVDD.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27984081" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5f823982c507a767d1917b7901f1ca22" rel="nofollow" data-download="{"attachment_id":48286519,"asset_id":27984081,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48286519/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33399028" href="https://independent.academia.edu/NiklasBergknut">Niklas Bergknut</a><script data-card-contents-for-user="33399028" type="text/json">{"id":33399028,"first_name":"Niklas","last_name":"Bergknut","domain_name":"independent","page_name":"NiklasBergknut","display_name":"Niklas Bergknut","profile_url":"https://independent.academia.edu/NiklasBergknut?f_ri=244814","photo":"https://0.academia-photos.com/33399028/13905881/14972206/s65_niklas.bergknut.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-27984081">+2</span><div class="hidden js-additional-users-27984081"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/AnneSofieLagerstedt">Anne-Sofie Lagerstedt</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://uu.academia.edu/Bj%C3%B6rnMeij">Björn Meij</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-27984081'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-27984081').html(); 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Prospective observational and analytic study. Objective. To investigate whether spontaneous intervertebral disc degeneration (IVDD) occurring in both chondrodystrophic (CD) and nonchondrodystrophic dogs (NCD) can be used as a valid translational model for human IVDD research. Summary of Background Data. Different animal models are used in IVDD research, but in most of these models IVDD is induced manually or chemically rather than occurring spontaneously. Methods. A total of 184 intervertebral discs (IVDs) from 19 dogs of different breeds were used. The extent of IVDD was evaluated by macroscopic grading, histopathology, glycosaminoglycan content, and matrix metalloproteinase 2 activity. Canine data were compared with human IVD data acquired in this study or from the literature. Results. Gross pathology of IVDD in both dog types (CD and NCD) and humans showed many similarities, but the cartilaginous endplates were signifi cantly thicker and the subchondral cortices signifi cantly thinner in humans than in dogs. Notochordal cells were still present in the IVDs of adult NCD but were not seen in the CD breeds or in humans. Signs of degeneration were seen in young dogs of CD breeds ( \u003c 1 year of age), whereas this was only seen in older dogs of NCD breeds (5-7 years of age). The relative glycosaminoglycan content and metalloproteinase 2 activity in canine IVDD were similar to those in humans: metalloproteinase 2 activity increased and glycosaminoglycan content decreased with increasing severity of IVDD. Conclusion. IVDD is similar in humans and dogs. Both CD and NCD breeds may therefore serve as models of spontaneous IVDD for human research. However, as with all animal models, it is important to recognize interspecies differences and, indeed, the intraspecies differences between CD and NCD breeds (early vs. late onset of IVDD, respectively) to develop an optimal canine model of human IVDD.","downloadable_attachments":[{"id":48286519,"asset_id":27984081,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33399028,"first_name":"Niklas","last_name":"Bergknut","domain_name":"independent","page_name":"NiklasBergknut","display_name":"Niklas Bergknut","profile_url":"https://independent.academia.edu/NiklasBergknut?f_ri=244814","photo":"https://0.academia-photos.com/33399028/13905881/14972206/s65_niklas.bergknut.jpg"},{"id":52466949,"first_name":"Anne-Sofie","last_name":"Lagerstedt","domain_name":"independent","page_name":"AnneSofieLagerstedt","display_name":"Anne-Sofie Lagerstedt","profile_url":"https://independent.academia.edu/AnneSofieLagerstedt?f_ri=244814","photo":"/images/s65_no_pic.png"},{"id":36418607,"first_name":"Björn","last_name":"Meij","domain_name":"uu","page_name":"BjörnMeij","display_name":"Björn Meij","profile_url":"https://uu.academia.edu/Bj%C3%B6rnMeij?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=244814","nofollow":true},{"id":4933,"name":"Spine","url":"https://www.academia.edu/Documents/in/Spine?f_ri=244814","nofollow":true},{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=244814","nofollow":true},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs?f_ri=244814","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=244814"},{"id":133360,"name":"Intervertebral disc","url":"https://www.academia.edu/Documents/in/Intervertebral_disc?f_ri=244814"},{"id":193017,"name":"Intervertebral disc degeneration","url":"https://www.academia.edu/Documents/in/Intervertebral_disc_degeneration?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":784076,"name":"Species Specificity","url":"https://www.academia.edu/Documents/in/Species_Specificity?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_76351815" data-work_id="76351815" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/76351815/Abstract_17311_Gut_Microbiota_Derived_Metabolites_Impact_Lymphatic_Inflammatory_Mechanisms">Abstract 17311: Gut Microbiota Derived Metabolites Impact Lymphatic Inflammatory Mechanisms</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Diet induced changes in gut microbial composition and dysregulated immune responses are key players in the progression of metabolic syndrome (MetSyn) and obesity.The lymphatics that are directly exposed to the gut microbiota in the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_76351815" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Diet induced changes in gut microbial composition and dysregulated immune responses are key players in the progression of metabolic syndrome (MetSyn) and obesity.The lymphatics that are directly exposed to the gut microbiota in the mesenteric bed are central players in inflammatory and immune responses and are impaired during MetSyn. However, the mechanisms remain unknown.Endogenous tryptophan derived gut microbiota metabolites such as indole, significantly limits inflammation and immune response. We hypothesize that microbiota influence the lymphatic mesenteric microenvironment via such discrete metabolites to impact metabolic disease. We evaluated the effects of indole, tryptamine and indole-3-acetate (I-3A) on inflammatory mechanisms in vitro and in vivo using cultured models of lymphatic endothelium (HDLECs) and rat models of high fructose diet induced MetSyn and LPS induced acute inflammation. HDLECs were treated with varying doses of indole, tryptamine and I-3A (100uM-500uM) i...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/76351815" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="98099624" href="https://independent.academia.edu/SabrinaDeLeonibus">Sabrina DeLeonibus</a><script data-card-contents-for-user="98099624" type="text/json">{"id":98099624,"first_name":"Sabrina","last_name":"DeLeonibus","domain_name":"independent","page_name":"SabrinaDeLeonibus","display_name":"Sabrina DeLeonibus","profile_url":"https://independent.academia.edu/SabrinaDeLeonibus?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_76351815 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="76351815"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 76351815, container: ".js-paper-rank-work_76351815", }); 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However, the mechanisms remain unknown.Endogenous tryptophan derived gut microbiota metabolites such as indole, significantly limits inflammation and immune response. We hypothesize that microbiota influence the lymphatic mesenteric microenvironment via such discrete metabolites to impact metabolic disease. We evaluated the effects of indole, tryptamine and indole-3-acetate (I-3A) on inflammatory mechanisms in vitro and in vivo using cultured models of lymphatic endothelium (HDLECs) and rat models of high fructose diet induced MetSyn and LPS induced acute inflammation. HDLECs were treated with varying doses of indole, tryptamine and I-3A (100uM-500uM) i...","downloadable_attachments":[],"ordered_authors":[{"id":98099624,"first_name":"Sabrina","last_name":"DeLeonibus","domain_name":"independent","page_name":"SabrinaDeLeonibus","display_name":"Sabrina DeLeonibus","profile_url":"https://independent.academia.edu/SabrinaDeLeonibus?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=244814","nofollow":true},{"id":515070,"name":"Circulation","url":"https://www.academia.edu/Documents/in/Circulation?f_ri=244814","nofollow":true},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=244814","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_62737836" data-work_id="62737836" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/62737836/PET_CT_and_breast_cancer">PET/CT and breast cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The use of general descriptive names, trademarks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_62737836" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The use of general descriptive names, trademarks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every case the user must check such information by consulting the relevant literature.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/62737836" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0e303f78235a72a81192d2e3196789c1" rel="nofollow" data-download="{"attachment_id":75408775,"asset_id":62737836,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75408775/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="209462481" href="https://unisr.academia.edu/mariapicchio">maria picchio</a><script data-card-contents-for-user="209462481" type="text/json">{"id":209462481,"first_name":"maria","last_name":"picchio","domain_name":"unisr","page_name":"mariapicchio","display_name":"maria picchio","profile_url":"https://unisr.academia.edu/mariapicchio?f_ri=244814","photo":"https://0.academia-photos.com/209462481/69272897/57669330/s65_maria.picchio.jpg"}</script></span></span></li><li class="js-paper-rank-work_62737836 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="62737836"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 62737836, container: ".js-paper-rank-work_62737836", }); 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$(".js-view-count[data-work-id=62737836]").text(description); $(".js-view-count-work_62737836").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_62737836").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="62737836"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1648" rel="nofollow" href="https://www.academia.edu/Documents/in/Computed_Tomography">Computed Tomography</a>, <script data-card-contents-for-ri="1648" type="text/json">{"id":1648,"name":"Computed Tomography","url":"https://www.academia.edu/Documents/in/Computed_Tomography?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6802" rel="nofollow" href="https://www.academia.edu/Documents/in/Breast_Cancer">Breast Cancer</a>, <script data-card-contents-for-ri="6802" type="text/json">{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="16664" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_assessment">Risk assessment</a>, <script data-card-contents-for-ri="16664" type="text/json">{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="23518" rel="nofollow" href="https://www.academia.edu/Documents/in/Positron_Emission_Tomography">Positron Emission Tomography</a><script data-card-contents-for-ri="23518" type="text/json">{"id":23518,"name":"Positron Emission Tomography","url":"https://www.academia.edu/Documents/in/Positron_Emission_Tomography?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=62737836]'), work: {"id":62737836,"title":"PET/CT and breast cancer","created_at":"2021-11-30T01:59:23.765-08:00","url":"https://www.academia.edu/62737836/PET_CT_and_breast_cancer?f_ri=244814","dom_id":"work_62737836","summary":"The use of general descriptive names, trademarks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every case the user must check such information by consulting the relevant literature.","downloadable_attachments":[{"id":75408775,"asset_id":62737836,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":209462481,"first_name":"maria","last_name":"picchio","domain_name":"unisr","page_name":"mariapicchio","display_name":"maria picchio","profile_url":"https://unisr.academia.edu/mariapicchio?f_ri=244814","photo":"https://0.academia-photos.com/209462481/69272897/57669330/s65_maria.picchio.jpg"}],"research_interests":[{"id":1648,"name":"Computed Tomography","url":"https://www.academia.edu/Documents/in/Computed_Tomography?f_ri=244814","nofollow":true},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=244814","nofollow":true},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=244814","nofollow":true},{"id":23518,"name":"Positron Emission Tomography","url":"https://www.academia.edu/Documents/in/Positron_Emission_Tomography?f_ri=244814","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=244814"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=244814"},{"id":532278,"name":"Cancer Patient","url":"https://www.academia.edu/Documents/in/Cancer_Patient?f_ri=244814"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=244814"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=244814"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=244814"},{"id":784086,"name":"Radiopharmaceuticals","url":"https://www.academia.edu/Documents/in/Radiopharmaceuticals?f_ri=244814"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=244814"},{"id":1779488,"name":"Breast Cancer Diagnosis","url":"https://www.academia.edu/Documents/in/Breast_Cancer_Diagnosis?f_ri=244814"},{"id":2439414,"name":"Magnetic resonance image","url":"https://www.academia.edu/Documents/in/Magnetic_resonance_image?f_ri=244814"},{"id":2463778,"name":"Clinical Trials as Topic","url":"https://www.academia.edu/Documents/in/Clinical_Trials_as_Topic?f_ri=244814"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1619951 coauthored" data-work_id="1619951" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1619951/Preimplantation_genetic_diagnosis_for_chromosome_rearrangements_one_blastomere_biopsy_versus_two_blastomere_biopsy">Preimplantation genetic diagnosis for chromosome rearrangements - one blastomere biopsy versus two blastomere biopsy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose Preimplantation Genetic Diagnosis (PGD) has proven to be a useful reproductive option for carriers of some chromosome rearrangements. The data presented in this study compares the impact of one versus two blastomere biopsy on the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_1619951" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose Preimplantation Genetic Diagnosis (PGD) has proven to be a useful reproductive option for carriers of some chromosome rearrangements. The data presented in this study compares the impact of one versus two blastomere biopsy on the likelihood of achieving a PGD result, as well as the effect on subsequent embryo development and clinical outcomes. Methods IVF-PGD couples had either one or two blastomeres biopsied from all embryos with ≥7 blastomeres on day 3 post oocyte collection. These blastomeres were assessed for the specific chromosome rearrangement using Fluorescent In-situ Hybridisation (FISH). Further embryo development was monitored on days 4 and 5. Clinical outcomes were assessed retrospectively. Results The data shows that statistically more embryos achieved a PGD result following two blastomere biopsy, compared with one blastomere biopsy (92 % versus 88 %, respectively). Furthermore it was found that embryo development and clinical outcomes were similar between the two biopsy groups. Conclusions Based on this analysis it appears that the biopsy of two blastomeres from embryos with ≥7 blastomeres on day 3 is a valid and successful approach for couples presenting for IVF-PGD for a chromosome rearrangement.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1619951" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5ec11227a5957bb100f92205b7ca5a0b" rel="nofollow" data-download="{"attachment_id":38202074,"asset_id":1619951,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/38202074/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="199710" href="https://griffith.academia.edu/SasanRasi">Dr. Sasan Rasi</a><script data-card-contents-for-user="199710" type="text/json">{"id":199710,"first_name":"Dr. Sasan","last_name":"Rasi","domain_name":"griffith","page_name":"SasanRasi","display_name":"Dr. Sasan Rasi","profile_url":"https://griffith.academia.edu/SasanRasi?f_ri=244814","photo":"https://0.academia-photos.com/199710/47176/43431/s65_sasan.rasi.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-1619951">+1</span><div class="hidden js-additional-users-1619951"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/BrodieD">D Brodie</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-1619951'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-1619951').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_1619951 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1619951"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1619951, container: ".js-paper-rank-work_1619951", }); });</script></li><li class="js-percentile-work_1619951 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 1619951; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_1619951"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_1619951 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="1619951"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 1619951; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=1619951]").text(description); $(".js-view-count-work_1619951").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_1619951").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="1619951"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37826" rel="nofollow" href="https://www.academia.edu/Documents/in/Biopsy">Biopsy</a>, <script data-card-contents-for-ri="37826" type="text/json">{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62550" rel="nofollow" href="https://www.academia.edu/Documents/in/Pregnancy">Pregnancy</a>, <script data-card-contents-for-ri="62550" type="text/json">{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65882" rel="nofollow" href="https://www.academia.edu/Documents/in/Fluorescence_in_situ_hybridization">Fluorescence in situ hybridization</a><script data-card-contents-for-ri="65882" type="text/json">{"id":65882,"name":"Fluorescence in situ hybridization","url":"https://www.academia.edu/Documents/in/Fluorescence_in_situ_hybridization?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=1619951]'), work: {"id":1619951,"title":"Preimplantation genetic diagnosis for chromosome rearrangements - one blastomere biopsy versus two blastomere biopsy","created_at":"2012-06-04T14:51:25.759-07:00","url":"https://www.academia.edu/1619951/Preimplantation_genetic_diagnosis_for_chromosome_rearrangements_one_blastomere_biopsy_versus_two_blastomere_biopsy?f_ri=244814","dom_id":"work_1619951","summary":"Purpose Preimplantation Genetic Diagnosis (PGD) has proven to be a useful reproductive option for carriers of some chromosome rearrangements. The data presented in this study compares the impact of one versus two blastomere biopsy on the likelihood of achieving a PGD result, as well as the effect on subsequent embryo development and clinical outcomes. Methods IVF-PGD couples had either one or two blastomeres biopsied from all embryos with ≥7 blastomeres on day 3 post oocyte collection. These blastomeres were assessed for the specific chromosome rearrangement using Fluorescent In-situ Hybridisation (FISH). Further embryo development was monitored on days 4 and 5. Clinical outcomes were assessed retrospectively. Results The data shows that statistically more embryos achieved a PGD result following two blastomere biopsy, compared with one blastomere biopsy (92 % versus 88 %, respectively). Furthermore it was found that embryo development and clinical outcomes were similar between the two biopsy groups. Conclusions Based on this analysis it appears that the biopsy of two blastomeres from embryos with ≥7 blastomeres on day 3 is a valid and successful approach for couples presenting for IVF-PGD for a chromosome rearrangement.","downloadable_attachments":[{"id":38202074,"asset_id":1619951,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":199710,"first_name":"Dr. Sasan","last_name":"Rasi","domain_name":"griffith","page_name":"SasanRasi","display_name":"Dr. Sasan Rasi","profile_url":"https://griffith.academia.edu/SasanRasi?f_ri=244814","photo":"https://0.academia-photos.com/199710/47176/43431/s65_sasan.rasi.jpg"},{"id":33265955,"first_name":"D","last_name":"Brodie","domain_name":"independent","page_name":"BrodieD","display_name":"D Brodie","profile_url":"https://independent.academia.edu/BrodieD?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=244814","nofollow":true},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy?f_ri=244814","nofollow":true},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=244814","nofollow":true},{"id":65882,"name":"Fluorescence in situ hybridization","url":"https://www.academia.edu/Documents/in/Fluorescence_in_situ_hybridization?f_ri=244814","nofollow":true},{"id":98922,"name":"Fertility and Sterility","url":"https://www.academia.edu/Documents/in/Fertility_and_Sterility?f_ri=244814"},{"id":210533,"name":"Embryo Transfer","url":"https://www.academia.edu/Documents/in/Embryo_Transfer?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":277616,"name":"Preimplantation genetic diagnosis","url":"https://www.academia.edu/Documents/in/Preimplantation_genetic_diagnosis?f_ri=244814"},{"id":352300,"name":"Embryonic Development","url":"https://www.academia.edu/Documents/in/Embryonic_Development?f_ri=244814"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=244814"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=244814"},{"id":613442,"name":"Fertilization in Vitro","url":"https://www.academia.edu/Documents/in/Fertilization_in_Vitro?f_ri=244814"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=244814"},{"id":1027717,"name":"Embryos","url":"https://www.academia.edu/Documents/in/Embryos?f_ri=244814"},{"id":1278603,"name":"Pregnancy Rate","url":"https://www.academia.edu/Documents/in/Pregnancy_Rate?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27371495 coauthored" data-work_id="27371495" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27371495/Presentation_and_Management_of_Splenic_Injury_After_Colonoscopy">Presentation and Management of Splenic Injury After Colonoscopy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This study reviewed all single experience of splenic injuries after colonoscopy in the last 40 years to define the possible risk factors and the management of this complication. A MEDLINE and a PubMed search was undertaken to identify... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27371495" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This study reviewed all single experience of splenic injuries after colonoscopy in the last 40 years to define the possible risk factors and the management of this complication. A MEDLINE and a PubMed search was undertaken to identify articles in English, French, Spanish, and Italian from 1974 to 2012 using the key words: "splenic injury," "splenic rupture," and "colonoscopy." Data were analyzed using descriptive statistic. A total of 103 cases have been described in 75 reports. The majority of the patients were women (71.56%) and 6.85% underwent previous pelvic surgery. The mean age was 63 years (range, 29 to 90 y). About 61 of the 103 studies (59.2%) reported the presence or the absence of previous abdominal surgery and within these, only 31 of 61 patients (50.82%) underwent previous abdominal surgery. In this review, over half of the patients with splenic injury underwent colonoscopy for routine surveillance (62.75%), and only one third of the splenic injures were associated with biopsy or polypectomy. The majority of patients (78.57%) developed symptoms within the first 24 hours after colonoscopy and in a minority of cases (21.43%), there was a delayed presentation 24 hours after colonoscopy. Computed tomography was used as the primary modality to make the diagnosis in 69 of 98 cases (70.41%) and as a confirmatory test in many additional cases. Twenty-six of 102 patients (25.49%) were treated by conservative methods, whereas the majority of patients (69.61%) underwent splenectomy as a definitive treatment. Because of possible medicolegal implications, the endoscopists should consider mentioning splenic injury on the consent form of colonoscopy after bowel perforation and bleeding, particularly in higher risk patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27371495" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a8401ea4a718c06bea2134beef9380a1" rel="nofollow" data-download="{"attachment_id":47625844,"asset_id":27371495,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47625844/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51489459" href="https://independent.academia.edu/FrancescoCard%C3%AC">Francesco Cardì</a><script data-card-contents-for-user="51489459" type="text/json">{"id":51489459,"first_name":"Francesco","last_name":"Cardì","domain_name":"independent","page_name":"FrancescoCardì","display_name":"Francesco Cardì","profile_url":"https://independent.academia.edu/FrancescoCard%C3%AC?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-27371495">+1</span><div class="hidden js-additional-users-27371495"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/PiccoloGaetano">Gaetano Piccolo</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-27371495'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-27371495').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_27371495 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27371495"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27371495, container: ".js-paper-rank-work_27371495", }); });</script></li><li class="js-percentile-work_27371495 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27371495; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_27371495"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_27371495 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="27371495"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27371495; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27371495]").text(description); $(".js-view-count-work_27371495").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27371495").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27371495"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="49018" rel="nofollow" href="https://www.academia.edu/Documents/in/Spleen">Spleen</a>, <script data-card-contents-for-ri="49018" type="text/json">{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192721" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_factors">Risk factors</a>, <script data-card-contents-for-ri="192721" type="text/json">{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="227324" rel="nofollow" href="https://www.academia.edu/Documents/in/Colonoscopy">Colonoscopy</a>, <script data-card-contents-for-ri="227324" type="text/json">{"id":227324,"name":"Colonoscopy","url":"https://www.academia.edu/Documents/in/Colonoscopy?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27371495]'), work: {"id":27371495,"title":"Presentation and Management of Splenic Injury After Colonoscopy","created_at":"2016-07-29T09:48:45.177-07:00","url":"https://www.academia.edu/27371495/Presentation_and_Management_of_Splenic_Injury_After_Colonoscopy?f_ri=244814","dom_id":"work_27371495","summary":"This study reviewed all single experience of splenic injuries after colonoscopy in the last 40 years to define the possible risk factors and the management of this complication. A MEDLINE and a PubMed search was undertaken to identify articles in English, French, Spanish, and Italian from 1974 to 2012 using the key words: \"splenic injury,\" \"splenic rupture,\" and \"colonoscopy.\" Data were analyzed using descriptive statistic. A total of 103 cases have been described in 75 reports. The majority of the patients were women (71.56%) and 6.85% underwent previous pelvic surgery. The mean age was 63 years (range, 29 to 90 y). About 61 of the 103 studies (59.2%) reported the presence or the absence of previous abdominal surgery and within these, only 31 of 61 patients (50.82%) underwent previous abdominal surgery. In this review, over half of the patients with splenic injury underwent colonoscopy for routine surveillance (62.75%), and only one third of the splenic injures were associated with biopsy or polypectomy. The majority of patients (78.57%) developed symptoms within the first 24 hours after colonoscopy and in a minority of cases (21.43%), there was a delayed presentation 24 hours after colonoscopy. Computed tomography was used as the primary modality to make the diagnosis in 69 of 98 cases (70.41%) and as a confirmatory test in many additional cases. Twenty-six of 102 patients (25.49%) were treated by conservative methods, whereas the majority of patients (69.61%) underwent splenectomy as a definitive treatment. Because of possible medicolegal implications, the endoscopists should consider mentioning splenic injury on the consent form of colonoscopy after bowel perforation and bleeding, particularly in higher risk patients.","downloadable_attachments":[{"id":47625844,"asset_id":27371495,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51489459,"first_name":"Francesco","last_name":"Cardì","domain_name":"independent","page_name":"FrancescoCardì","display_name":"Francesco Cardì","profile_url":"https://independent.academia.edu/FrancescoCard%C3%AC?f_ri=244814","photo":"/images/s65_no_pic.png"},{"id":51602444,"first_name":"Gaetano","last_name":"Piccolo","domain_name":"independent","page_name":"PiccoloGaetano","display_name":"Gaetano Piccolo","profile_url":"https://independent.academia.edu/PiccoloGaetano?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen?f_ri=244814","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=244814","nofollow":true},{"id":227324,"name":"Colonoscopy","url":"https://www.academia.edu/Documents/in/Colonoscopy?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=244814"},{"id":2190600,"name":"Splenectomy","url":"https://www.academia.edu/Documents/in/Splenectomy?f_ri=244814"},{"id":2484079,"name":"splenic rupture","url":"https://www.academia.edu/Documents/in/splenic_rupture?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_56190060" data-work_id="56190060" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/56190060/The_Roots_of_Autism_and_ADHD_Twin_Study_in_Sweden_RATSS_">The Roots of Autism and ADHD Twin Study in Sweden (RATSS)</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neurodevelopmental disorders affect a substantial minority of the general population. Their origins are still largely unknown, but a complex interplay of genetic and environmental factors causing disturbances of the central nervous... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_56190060" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neurodevelopmental disorders affect a substantial minority of the general population. Their origins are still largely unknown, but a complex interplay of genetic and environmental factors causing disturbances of the central nervous system's maturation and a variety of higher cognitive skills is presumed. Only limited research of rather small sample size and narrow scope has been conducted in neurodevelopmental disorders using a twin-differences design. The Roots of Autism and ADHD Twin Study in Sweden (RATSS) is an ongoing project targeting monozygotic twins discordant for categorical or dimensional autistic and inattentive/hyperactive-impulsive phenotypes as well as other neurodevelopmental disorders, and typically developing twin controls. Included pairs are 9 years of age or older, and comprehensively assessed for psychopathology, medical history, neuropsychology, and dysmorphology, as well as structural, functional, and molecular brain imaging. Specimens are collected for induced pluripotent (iPS) and neuroepithelial stem cells, genetic, gut bacteria, protein-/monoamine, and electron microscopy analyses. RATSS's objective is to generate a launch pad for novel surveys to understand the complexity of genotype-environmentphenotype interactions in autism spectrum disorder and attention-deficit hyperactivity disorder (ADHD). By October 2013, RATSS had collected data from 55 twin pairs, among them 10 monozygotic pairs discordant for autism spectrum disorder, seven for ADHD, and four for other neurodevelopmental disorders.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/56190060" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="da334e324cdf9981bb93c28275757fd1" rel="nofollow" data-download="{"attachment_id":71697866,"asset_id":56190060,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71697866/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="100619775" href="https://independent.academia.edu/RSitkow">R. Sitkow</a><script data-card-contents-for-user="100619775" type="text/json">{"id":100619775,"first_name":"R.","last_name":"Sitkow","domain_name":"independent","page_name":"RSitkow","display_name":"R. Sitkow","profile_url":"https://independent.academia.edu/RSitkow?f_ri=244814","photo":"https://0.academia-photos.com/100619775/22797716/21957667/s65_r..sitkow.jpg"}</script></span></span></li><li class="js-paper-rank-work_56190060 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="56190060"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 56190060, container: ".js-paper-rank-work_56190060", }); });</script></li><li class="js-percentile-work_56190060 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 56190060; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_56190060"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_56190060 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="56190060"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 56190060; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=56190060]").text(description); $(".js-view-count-work_56190060").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_56190060").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="56190060"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2639" rel="nofollow" href="https://www.academia.edu/Documents/in/Neuroimaging">Neuroimaging</a>, <script data-card-contents-for-ri="2639" type="text/json">{"id":2639,"name":"Neuroimaging","url":"https://www.academia.edu/Documents/in/Neuroimaging?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4212" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a>, <script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=56190060]'), work: {"id":56190060,"title":"The Roots of Autism and ADHD Twin Study in Sweden (RATSS)","created_at":"2021-10-07T00:30:32.205-07:00","url":"https://www.academia.edu/56190060/The_Roots_of_Autism_and_ADHD_Twin_Study_in_Sweden_RATSS_?f_ri=244814","dom_id":"work_56190060","summary":"Neurodevelopmental disorders affect a substantial minority of the general population. Their origins are still largely unknown, but a complex interplay of genetic and environmental factors causing disturbances of the central nervous system's maturation and a variety of higher cognitive skills is presumed. Only limited research of rather small sample size and narrow scope has been conducted in neurodevelopmental disorders using a twin-differences design. The Roots of Autism and ADHD Twin Study in Sweden (RATSS) is an ongoing project targeting monozygotic twins discordant for categorical or dimensional autistic and inattentive/hyperactive-impulsive phenotypes as well as other neurodevelopmental disorders, and typically developing twin controls. Included pairs are 9 years of age or older, and comprehensively assessed for psychopathology, medical history, neuropsychology, and dysmorphology, as well as structural, functional, and molecular brain imaging. Specimens are collected for induced pluripotent (iPS) and neuroepithelial stem cells, genetic, gut bacteria, protein-/monoamine, and electron microscopy analyses. RATSS's objective is to generate a launch pad for novel surveys to understand the complexity of genotype-environmentphenotype interactions in autism spectrum disorder and attention-deficit hyperactivity disorder (ADHD). By October 2013, RATSS had collected data from 55 twin pairs, among them 10 monozygotic pairs discordant for autism spectrum disorder, seven for ADHD, and four for other neurodevelopmental disorders.","downloadable_attachments":[{"id":71697866,"asset_id":56190060,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":100619775,"first_name":"R.","last_name":"Sitkow","domain_name":"independent","page_name":"RSitkow","display_name":"R. Sitkow","profile_url":"https://independent.academia.edu/RSitkow?f_ri=244814","photo":"https://0.academia-photos.com/100619775/22797716/21957667/s65_r..sitkow.jpg"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=244814","nofollow":true},{"id":2639,"name":"Neuroimaging","url":"https://www.academia.edu/Documents/in/Neuroimaging?f_ri=244814","nofollow":true},{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=244814","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=244814","nofollow":true},{"id":44814,"name":"Sweden","url":"https://www.academia.edu/Documents/in/Sweden?f_ri=244814"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=244814"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=244814"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":1208706,"name":"Environment","url":"https://www.academia.edu/Documents/in/Environment?f_ri=244814"},{"id":2467529,"name":"Psychiatric Status Rating Scales","url":"https://www.academia.edu/Documents/in/Psychiatric_Status_Rating_Scales?f_ri=244814"},{"id":2489699,"name":"Autistic disorder","url":"https://www.academia.edu/Documents/in/Autistic_disorder?f_ri=244814"},{"id":2526151,"name":"Attention deficit disorder with hyperactivity","url":"https://www.academia.edu/Documents/in/Attention_deficit_disorder_with_hyperactivity?f_ri=244814"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14228200" data-work_id="14228200" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14228200/Psychological_characteristics_of_religious_delusions">Psychological characteristics of religious delusions</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose Religious delusions are common and are considered to be particularly difficult to treat. In this study we investigated what psychological processes may underlie the reported treatment resistance. In particular, we focused on the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14228200" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose Religious delusions are common and are considered to be particularly difficult to treat. In this study we investigated what psychological processes may underlie the reported treatment resistance. In particular, we focused on the perceptual, cognitive, affective and behavioural mechanisms held to maintain delusions in cognitive models of psychosis, as these form the key treatment targets in cognitive behavioural therapy. We compared religious delusions to delusions with other content. Methods Comprehensive measures of symptoms and psychological processes were completed by 383 adult participants with delusions and a schizophrenia spectrum diagnosis, drawn from two large studies of cognitive behavioural therapy for psychosis. Results Binary logistic regression showed that religious delusions were associated with higher levels of grandiosity (OR 7.5; 95 % CI 3.9-14.1), passivity experiences, having internal evidence for their delusion (anomalous experiences or mood states), and being willing to consider alternatives to their delusion (95 % CI for ORs 1.1-8.6). Levels of negative symptoms were lower. No differences were found in delusional conviction, insight or attitudes towards treatment. Conclusions Levels of positive symptoms, particularly anomalous experiences and grandiosity, were high, and may contribute to symptom persistence. However, contrary to previous reports, we found no evidence that people with religious delusions would be less likely to engage in any form of help. Higher levels of flexibility may make them particularly amenable to cognitive behavioural approaches, but particular care should be taken to preserve self-esteem and valued aspects of beliefs and experiences.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14228200" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6e1fa7f6c6c2509b23b641f63aa784d8" rel="nofollow" data-download="{"attachment_id":44434297,"asset_id":14228200,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44434297/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="6926715" href="https://pkcl.academia.edu/AmyHardy">Amy Hardy</a><script data-card-contents-for-user="6926715" type="text/json">{"id":6926715,"first_name":"Amy","last_name":"Hardy","domain_name":"pkcl","page_name":"AmyHardy","display_name":"Amy Hardy","profile_url":"https://pkcl.academia.edu/AmyHardy?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14228200 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14228200"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14228200, container: ".js-paper-rank-work_14228200", }); 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$(".js-view-count[data-work-id=14228200]").text(description); $(".js-view-count-work_14228200").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14228200").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14228200"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="38385" rel="nofollow" href="https://www.academia.edu/Documents/in/Delusions">Delusions</a><script data-card-contents-for-ri="38385" type="text/json">{"id":38385,"name":"Delusions","url":"https://www.academia.edu/Documents/in/Delusions?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14228200]'), work: {"id":14228200,"title":"Psychological characteristics of religious delusions","created_at":"2015-07-20T13:37:02.152-07:00","url":"https://www.academia.edu/14228200/Psychological_characteristics_of_religious_delusions?f_ri=244814","dom_id":"work_14228200","summary":"Purpose Religious delusions are common and are considered to be particularly difficult to treat. In this study we investigated what psychological processes may underlie the reported treatment resistance. In particular, we focused on the perceptual, cognitive, affective and behavioural mechanisms held to maintain delusions in cognitive models of psychosis, as these form the key treatment targets in cognitive behavioural therapy. We compared religious delusions to delusions with other content. Methods Comprehensive measures of symptoms and psychological processes were completed by 383 adult participants with delusions and a schizophrenia spectrum diagnosis, drawn from two large studies of cognitive behavioural therapy for psychosis. Results Binary logistic regression showed that religious delusions were associated with higher levels of grandiosity (OR 7.5; 95 % CI 3.9-14.1), passivity experiences, having internal evidence for their delusion (anomalous experiences or mood states), and being willing to consider alternatives to their delusion (95 % CI for ORs 1.1-8.6). Levels of negative symptoms were lower. No differences were found in delusional conviction, insight or attitudes towards treatment. Conclusions Levels of positive symptoms, particularly anomalous experiences and grandiosity, were high, and may contribute to symptom persistence. However, contrary to previous reports, we found no evidence that people with religious delusions would be less likely to engage in any form of help. Higher levels of flexibility may make them particularly amenable to cognitive behavioural approaches, but particular care should be taken to preserve self-esteem and valued aspects of beliefs and experiences.","downloadable_attachments":[{"id":44434297,"asset_id":14228200,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":6926715,"first_name":"Amy","last_name":"Hardy","domain_name":"pkcl","page_name":"AmyHardy","display_name":"Amy Hardy","profile_url":"https://pkcl.academia.edu/AmyHardy?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=244814","nofollow":true},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=244814","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=244814","nofollow":true},{"id":38385,"name":"Delusions","url":"https://www.academia.edu/Documents/in/Delusions?f_ri=244814","nofollow":true},{"id":101797,"name":"Cognitive Therapy","url":"https://www.academia.edu/Documents/in/Cognitive_Therapy?f_ri=244814"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=244814"},{"id":144049,"name":"Attitude","url":"https://www.academia.edu/Documents/in/Attitude?f_ri=244814"},{"id":161134,"name":"Social Psychiatry","url":"https://www.academia.edu/Documents/in/Social_Psychiatry?f_ri=244814"},{"id":165710,"name":"Religion and psychology","url":"https://www.academia.edu/Documents/in/Religion_and_psychology?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814"},{"id":321147,"name":"Self Concept","url":"https://www.academia.edu/Documents/in/Self_Concept?f_ri=244814"},{"id":612870,"name":"Psychotic Disorders","url":"https://www.academia.edu/Documents/in/Psychotic_Disorders?f_ri=244814"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21651075" data-work_id="21651075" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21651075/Heart_specific_up_regulation_of_genes_for_B_type_and_C_type_natriuretic_peptide_receptors_in_diabetic_mice">Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21651075" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B ( NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21651075" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ac475ee3a9a8fb4fba68c48df0141bc5" rel="nofollow" data-download="{"attachment_id":42292249,"asset_id":21651075,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42292249/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32490701" href="https://independent.academia.edu/ChristoffersenC">C. Christoffersen</a><script data-card-contents-for-user="32490701" type="text/json">{"id":32490701,"first_name":"C.","last_name":"Christoffersen","domain_name":"independent","page_name":"ChristoffersenC","display_name":"C. Christoffersen","profile_url":"https://independent.academia.edu/ChristoffersenC?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21651075 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21651075"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21651075, container: ".js-paper-rank-work_21651075", }); });</script></li><li class="js-percentile-work_21651075 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21651075; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21651075"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21651075 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21651075"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21651075; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21651075]").text(description); $(".js-view-count-work_21651075").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21651075").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21651075"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="84760" rel="nofollow" href="https://www.academia.edu/Documents/in/Mice">Mice</a>, <script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="116889" rel="nofollow" href="https://www.academia.edu/Documents/in/Natriuretic_Peptides">Natriuretic Peptides</a>, <script data-card-contents-for-ri="116889" type="text/json">{"id":116889,"name":"Natriuretic Peptides","url":"https://www.academia.edu/Documents/in/Natriuretic_Peptides?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="131495" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart">Heart</a>, <script data-card-contents-for-ri="131495" type="text/json">{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21651075]'), work: {"id":21651075,"title":"Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice","created_at":"2016-02-07T04:05:34.927-08:00","url":"https://www.academia.edu/21651075/Heart_specific_up_regulation_of_genes_for_B_type_and_C_type_natriuretic_peptide_receptors_in_diabetic_mice?f_ri=244814","dom_id":"work_21651075","summary":"Background Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B ( NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.","downloadable_attachments":[{"id":42292249,"asset_id":21651075,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32490701,"first_name":"C.","last_name":"Christoffersen","domain_name":"independent","page_name":"ChristoffersenC","display_name":"C. Christoffersen","profile_url":"https://independent.academia.edu/ChristoffersenC?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=244814","nofollow":true},{"id":116889,"name":"Natriuretic Peptides","url":"https://www.academia.edu/Documents/in/Natriuretic_Peptides?f_ri=244814","nofollow":true},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor?f_ri=244814"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus?f_ri=244814"},{"id":1621878,"name":"Guanylate Cyclase","url":"https://www.academia.edu/Documents/in/Guanylate_Cyclase?f_ri=244814"},{"id":2015813,"name":"Atrial Natriuretic Factor","url":"https://www.academia.edu/Documents/in/Atrial_Natriuretic_Factor?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_31960000" data-work_id="31960000" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/31960000/Construct_Validation_and_Test_Retest_Reliability_of_the_Seniors_in_the_Community_Risk_Evaluation_for_Eating_and_Nutrition_Questionnaire">Construct Validation and Test-Retest Reliability of the Seniors in the Community: Risk Evaluation for Eating and Nutrition Questionnaire</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We performed two studies. Study 1 was a construct validation of Seniors in the Community: Risk Evaluation for Eating and Nutrition (SCREEN), a 15-item questionnaire for assessing nutritional risk. In Study 2, we examined the test-retest... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_31960000" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We performed two studies. Study 1 was a construct validation of Seniors in the Community: Risk Evaluation for Eating and Nutrition (SCREEN), a 15-item questionnaire for assessing nutritional risk. In Study 2, we examined the test-retest reliability of SCREEN.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31960000" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7e87d5bf49e47db92b8cfb4d5bec4392" rel="nofollow" data-download="{"attachment_id":52235246,"asset_id":31960000,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52235246/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40841345" href="https://uwaterloo.academia.edu/HeatherKeller">Heather Keller</a><script data-card-contents-for-user="40841345" type="text/json">{"id":40841345,"first_name":"Heather","last_name":"Keller","domain_name":"uwaterloo","page_name":"HeatherKeller","display_name":"Heather Keller","profile_url":"https://uwaterloo.academia.edu/HeatherKeller?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_31960000 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="31960000"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 31960000, container: ".js-paper-rank-work_31960000", }); 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$(".js-view-count[data-work-id=31960000]").text(description); $(".js-view-count-work_31960000").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_31960000").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="31960000"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="8207" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk">Risk</a>, <script data-card-contents-for-ri="8207" type="text/json">{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="104434" rel="nofollow" href="https://www.academia.edu/Documents/in/Construct_Validity">Construct Validity</a>, <script data-card-contents-for-ri="104434" type="text/json">{"id":104434,"name":"Construct Validity","url":"https://www.academia.edu/Documents/in/Construct_Validity?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="131185" rel="nofollow" href="https://www.academia.edu/Documents/in/Cohort_Study">Cohort Study</a>, <script data-card-contents-for-ri="131185" type="text/json">{"id":131185,"name":"Cohort Study","url":"https://www.academia.edu/Documents/in/Cohort_Study?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192551" rel="nofollow" href="https://www.academia.edu/Documents/in/Nutritional_Status">Nutritional Status</a><script data-card-contents-for-ri="192551" type="text/json">{"id":192551,"name":"Nutritional Status","url":"https://www.academia.edu/Documents/in/Nutritional_Status?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=31960000]'), work: {"id":31960000,"title":"Construct Validation and Test-Retest Reliability of the Seniors in the Community: Risk Evaluation for Eating and Nutrition Questionnaire","created_at":"2017-03-21T04:13:02.582-07:00","url":"https://www.academia.edu/31960000/Construct_Validation_and_Test_Retest_Reliability_of_the_Seniors_in_the_Community_Risk_Evaluation_for_Eating_and_Nutrition_Questionnaire?f_ri=244814","dom_id":"work_31960000","summary":"We performed two studies. Study 1 was a construct validation of Seniors in the Community: Risk Evaluation for Eating and Nutrition (SCREEN), a 15-item questionnaire for assessing nutritional risk. In Study 2, we examined the test-retest reliability of SCREEN.","downloadable_attachments":[{"id":52235246,"asset_id":31960000,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40841345,"first_name":"Heather","last_name":"Keller","domain_name":"uwaterloo","page_name":"HeatherKeller","display_name":"Heather Keller","profile_url":"https://uwaterloo.academia.edu/HeatherKeller?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=244814","nofollow":true},{"id":104434,"name":"Construct Validity","url":"https://www.academia.edu/Documents/in/Construct_Validity?f_ri=244814","nofollow":true},{"id":131185,"name":"Cohort Study","url":"https://www.academia.edu/Documents/in/Cohort_Study?f_ri=244814","nofollow":true},{"id":192551,"name":"Nutritional Status","url":"https://www.academia.edu/Documents/in/Nutritional_Status?f_ri=244814","nofollow":true},{"id":199316,"name":"Multiple Linear Regression","url":"https://www.academia.edu/Documents/in/Multiple_Linear_Regression?f_ri=244814"},{"id":218820,"name":"Eating","url":"https://www.academia.edu/Documents/in/Eating?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814"},{"id":806178,"name":"Older Adult","url":"https://www.academia.edu/Documents/in/Older_Adult?f_ri=244814"},{"id":860345,"name":"Low Risk","url":"https://www.academia.edu/Documents/in/Low_Risk?f_ri=244814"},{"id":955137,"name":"Risk Evaluation","url":"https://www.academia.edu/Documents/in/Risk_Evaluation?f_ri=244814"},{"id":966020,"name":"Cross sectional Study","url":"https://www.academia.edu/Documents/in/Cross_sectional_Study?f_ri=244814"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=244814"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_34351459" data-work_id="34351459" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/34351459/Characteristics_of_Spontaneous_Activity_in_the_Bladder_Trigone">Characteristics of Spontaneous Activity in the Bladder Trigone</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: During bladder filling, the trigone contracts help keep the ureteral orifices open and the bladder neck shut. The trigone generates spontaneous activity as well as responding to neuromuscular transmitters, but the relationship... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_34351459" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: During bladder filling, the trigone contracts help keep the ureteral orifices open and the bladder neck shut. The trigone generates spontaneous activity as well as responding to neuromuscular transmitters, but the relationship between these phenomena are unclear. Objectives: To characterise the cellular mechanisms that regulate and modify spontaneous activity in trigone smooth muscle. Design, setting, and participants: Muscle strips from the superficial trigone of male guinea-pigs were used for tension experiments and immunofluorescent studies. Measurements: In isolated trigonal cells, intracellular Ca 2+ was measured by epifluorescence microscopy using the fluorescent Ca 2+ indicator Fura-2. Results and limitations: Spontaneous intracellular Ca 2+ transients and contractions were observed in trigonal single cells and strips and were significantly higher compared to the bladder dome. Ca-free superfusate and verapamil terminated spontaneity. T-type Ca 2+ channel block with NiCl 2 depressed slightly Ca 2+ transients but not spontaneous contractions. Neither the BK Ca channel blocker iberiotoxin nor the SK Ca channel blocker apamin had any effect on single cell activity. By contrast, the Cl À channel blocker niflumic acid attenuated significantly both Ca 2+ transients and muscle contractions. Agonist stimulation (carbachol, phenylephrine) up-regulated activity. Gap junction labelling (Cx43) was approximately 5 times denser in the trigone than in detrusor smooth muscle. The gap junction blocker 18-ß-glycyrrhetinic acid modulated spontaneous contractions in the trigone but not in the bladder dome. Conclusions: Trigone myocytes employ membrane L-type-Ca 2+ channels and Cl À channels to generate spontaneous activity. Intercellular electrical coupling ensures its propagation and, thus, sustains contraction of the whole trigone.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/34351459" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5ab000f5f28dee9f170d3774073e5d44" rel="nofollow" data-download="{"attachment_id":54243546,"asset_id":34351459,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54243546/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="10264" href="https://imperial.academia.edu/RashedaChowdhury">Rasheda Chowdhury</a><script data-card-contents-for-user="10264" type="text/json">{"id":10264,"first_name":"Rasheda","last_name":"Chowdhury","domain_name":"imperial","page_name":"RashedaChowdhury","display_name":"Rasheda Chowdhury","profile_url":"https://imperial.academia.edu/RashedaChowdhury?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_34351459 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="34351459"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 34351459, container: ".js-paper-rank-work_34351459", }); });</script></li><li class="js-percentile-work_34351459 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34351459; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_34351459"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_34351459 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="34351459"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34351459; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34351459]").text(description); $(".js-view-count-work_34351459").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_34351459").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="34351459"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="622" rel="nofollow" href="https://www.academia.edu/Documents/in/Nephrology">Nephrology</a>, <script data-card-contents-for-ri="622" type="text/json">{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="653" rel="nofollow" href="https://www.academia.edu/Documents/in/Urology">Urology</a>, <script data-card-contents-for-ri="653" type="text/json">{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9534" rel="nofollow" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a>, <script data-card-contents-for-ri="9534" type="text/json">{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65171" rel="nofollow" href="https://www.academia.edu/Documents/in/Smooth_muscle">Smooth muscle</a><script data-card-contents-for-ri="65171" type="text/json">{"id":65171,"name":"Smooth muscle","url":"https://www.academia.edu/Documents/in/Smooth_muscle?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=34351459]'), work: {"id":34351459,"title":"Characteristics of Spontaneous Activity in the Bladder Trigone","created_at":"2017-08-25T06:17:04.430-07:00","url":"https://www.academia.edu/34351459/Characteristics_of_Spontaneous_Activity_in_the_Bladder_Trigone?f_ri=244814","dom_id":"work_34351459","summary":"Background: During bladder filling, the trigone contracts help keep the ureteral orifices open and the bladder neck shut. The trigone generates spontaneous activity as well as responding to neuromuscular transmitters, but the relationship between these phenomena are unclear. Objectives: To characterise the cellular mechanisms that regulate and modify spontaneous activity in trigone smooth muscle. Design, setting, and participants: Muscle strips from the superficial trigone of male guinea-pigs were used for tension experiments and immunofluorescent studies. Measurements: In isolated trigonal cells, intracellular Ca 2+ was measured by epifluorescence microscopy using the fluorescent Ca 2+ indicator Fura-2. Results and limitations: Spontaneous intracellular Ca 2+ transients and contractions were observed in trigonal single cells and strips and were significantly higher compared to the bladder dome. Ca-free superfusate and verapamil terminated spontaneity. T-type Ca 2+ channel block with NiCl 2 depressed slightly Ca 2+ transients but not spontaneous contractions. Neither the BK Ca channel blocker iberiotoxin nor the SK Ca channel blocker apamin had any effect on single cell activity. By contrast, the Cl À channel blocker niflumic acid attenuated significantly both Ca 2+ transients and muscle contractions. Agonist stimulation (carbachol, phenylephrine) up-regulated activity. Gap junction labelling (Cx43) was approximately 5 times denser in the trigone than in detrusor smooth muscle. The gap junction blocker 18-ß-glycyrrhetinic acid modulated spontaneous contractions in the trigone but not in the bladder dome. Conclusions: Trigone myocytes employ membrane L-type-Ca 2+ channels and Cl À channels to generate spontaneous activity. Intercellular electrical coupling ensures its propagation and, thus, sustains contraction of the whole trigone.","downloadable_attachments":[{"id":54243546,"asset_id":34351459,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":10264,"first_name":"Rasheda","last_name":"Chowdhury","domain_name":"imperial","page_name":"RashedaChowdhury","display_name":"Rasheda Chowdhury","profile_url":"https://imperial.academia.edu/RashedaChowdhury?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology?f_ri=244814","nofollow":true},{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology?f_ri=244814","nofollow":true},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=244814","nofollow":true},{"id":65171,"name":"Smooth muscle","url":"https://www.academia.edu/Documents/in/Smooth_muscle?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":419061,"name":"Urinary System","url":"https://www.academia.edu/Documents/in/Urinary_System?f_ri=244814"},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig?f_ri=244814"},{"id":556021,"name":"Muscle contraction","url":"https://www.academia.edu/Documents/in/Muscle_contraction?f_ri=244814"},{"id":633766,"name":"Sediment Characteristic","url":"https://www.academia.edu/Documents/in/Sediment_Characteristic?f_ri=244814"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity?f_ri=244814"},{"id":1902592,"name":"Urinary Bladder","url":"https://www.academia.edu/Documents/in/Urinary_Bladder?f_ri=244814"},{"id":2111545,"name":"Spontaneous Activity","url":"https://www.academia.edu/Documents/in/Spontaneous_Activity?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18191321" data-work_id="18191321" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18191321/Alternative_pathways_for_hydrogen_disposal_during_fermentation_in_the_human_colon">Alternative pathways for hydrogen disposal during fermentation in the human colon</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Hydrogen gas, which is produced during fermentation in the human colon, is either excreted in breath or metabolised by gut bacteria through a variety of pathways. These may include methanogenesis, dissimilatory sulphate reduction, and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18191321" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Hydrogen gas, which is produced during fermentation in the human colon, is either excreted in breath or metabolised by gut bacteria through a variety of pathways. These may include methanogenesis, dissimilatory sulphate reduction, and acetogenesis. To determine which of these routes predominates in the large intestine, stools were taken from 30 healthy subjects and incubated as 5% (w/v) slurries with Lintner's starch. In 23 of 30 subjects, methane production was the main method of hydrogen disposal. In the remaining seven, high rates of sulphate reduction were recorded together with raised production of H2S. All samples showed relatively low rates of hydrogen evolution and of acetate formation from CO2 and H2. Sulphate reduction and</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18191321" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="88da8d3565c99ff7fe47c688fa6b8fae" rel="nofollow" data-download="{"attachment_id":42097699,"asset_id":18191321,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42097699/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38174348" href="https://dundee.academia.edu/JohnCummings">John Cummings</a><script data-card-contents-for-user="38174348" type="text/json">{"id":38174348,"first_name":"John","last_name":"Cummings","domain_name":"dundee","page_name":"JohnCummings","display_name":"John Cummings","profile_url":"https://dundee.academia.edu/JohnCummings?f_ri=244814","photo":"https://0.academia-photos.com/38174348/18917248/18868708/s65_john.cummings.jpg"}</script></span></span></li><li class="js-paper-rank-work_18191321 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18191321"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18191321, container: ".js-paper-rank-work_18191321", }); 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$(".js-view-count[data-work-id=18191321]").text(description); $(".js-view-count-work_18191321").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18191321").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18191321"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3771" rel="nofollow" href="https://www.academia.edu/Documents/in/Hydrogen">Hydrogen</a>, <script data-card-contents-for-ri="3771" type="text/json">{"id":3771,"name":"Hydrogen","url":"https://www.academia.edu/Documents/in/Hydrogen?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="156347" rel="nofollow" href="https://www.academia.edu/Documents/in/Methane">Methane</a>, <script data-card-contents-for-ri="156347" type="text/json">{"id":156347,"name":"Methane","url":"https://www.academia.edu/Documents/in/Methane?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="269129" rel="nofollow" href="https://www.academia.edu/Documents/in/Fermentation">Fermentation</a><script data-card-contents-for-ri="269129" type="text/json">{"id":269129,"name":"Fermentation","url":"https://www.academia.edu/Documents/in/Fermentation?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18191321]'), work: {"id":18191321,"title":"Alternative pathways for hydrogen disposal during fermentation in the human colon","created_at":"2015-11-12T02:29:58.823-08:00","url":"https://www.academia.edu/18191321/Alternative_pathways_for_hydrogen_disposal_during_fermentation_in_the_human_colon?f_ri=244814","dom_id":"work_18191321","summary":"Hydrogen gas, which is produced during fermentation in the human colon, is either excreted in breath or metabolised by gut bacteria through a variety of pathways. These may include methanogenesis, dissimilatory sulphate reduction, and acetogenesis. To determine which of these routes predominates in the large intestine, stools were taken from 30 healthy subjects and incubated as 5% (w/v) slurries with Lintner's starch. In 23 of 30 subjects, methane production was the main method of hydrogen disposal. In the remaining seven, high rates of sulphate reduction were recorded together with raised production of H2S. All samples showed relatively low rates of hydrogen evolution and of acetate formation from CO2 and H2. Sulphate reduction and","downloadable_attachments":[{"id":42097699,"asset_id":18191321,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38174348,"first_name":"John","last_name":"Cummings","domain_name":"dundee","page_name":"JohnCummings","display_name":"John Cummings","profile_url":"https://dundee.academia.edu/JohnCummings?f_ri=244814","photo":"https://0.academia-photos.com/38174348/18917248/18868708/s65_john.cummings.jpg"}],"research_interests":[{"id":3771,"name":"Hydrogen","url":"https://www.academia.edu/Documents/in/Hydrogen?f_ri=244814","nofollow":true},{"id":156347,"name":"Methane","url":"https://www.academia.edu/Documents/in/Methane?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":269129,"name":"Fermentation","url":"https://www.academia.edu/Documents/in/Fermentation?f_ri=244814","nofollow":true},{"id":469102,"name":"Feces","url":"https://www.academia.edu/Documents/in/Feces?f_ri=244814"},{"id":537750,"name":"Gut","url":"https://www.academia.edu/Documents/in/Gut?f_ri=244814"},{"id":829416,"name":"Colon","url":"https://www.academia.edu/Documents/in/Colon?f_ri=244814"},{"id":1137254,"name":"Hydrogen-Ion Concentration","url":"https://www.academia.edu/Documents/in/Hydrogen-Ion_Concentration?f_ri=244814"},{"id":1142759,"name":"Healthy Subjects","url":"https://www.academia.edu/Documents/in/Healthy_Subjects?f_ri=244814"},{"id":1317988,"name":"Sulphate Reducing Bacteria","url":"https://www.academia.edu/Documents/in/Sulphate_Reducing_Bacteria?f_ri=244814"},{"id":1663770,"name":"Sulfates","url":"https://www.academia.edu/Documents/in/Sulfates?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_8274074" data-work_id="8274074" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/8274074/Topical_amethocaine_Ametop_is_superior_to_EMLA_for_intravenous_cannulation">Topical amethocaine (Ametop™) is superior to EMLA for intravenous cannulation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose A eutectic mixture of local anesthetics (EMLA) is commonly used to provide topical anesthesia for intravenous (iv) cannulation. One of its side effects is vasoconstriction, which may render cannulation more difficult. A gel... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_8274074" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose A eutectic mixture of local anesthetics (EMLA) is commonly used to provide topical anesthesia for intravenous (iv) cannulation. One of its side effects is vasoconstriction, which may render cannulation more difficult. A gel formulation of amethocaine (Ametop™) is now commercially available. The aim of this study was to compare EMLA and Ametop™ with regard to the degree of topical anesthesia afforded, the incidence of vasoconstriction and the ease of iv cannulation. Methods Thirty two ASA 1 adult volunteers had a # 16 gauge iv cannula inserted on two separate occasions using EMLA and Ametop™ applied in a double blind fashion for topical anesthesia. Parameters that were recorded after each cannulation included visual analogue pain scores (VAPS), the presence of vasoconstriction and the ease of cannulation, graded as: 1 = easy, 2 = moderately difficult, 3 = difficult and 4 = failed. Results The mean VAPS ± SD after cannulation with Ametop™ M was 12 ± 9.9 and with EMLA was 25.3 ± 16.6 (P = 0.002). Vasoconstriction occurred after EMLA application on 17 occasions and twice after Ametop™ (P = 0.001). The grade of difficulty of cannulation was 1.44 ± 0.88 following EMLA and 1.06 ± 0.25 with Ametop™ (P = 0.023). Conclusions Intravenous cannulation was less painful following application of Ametop™ than EMLA. In addition, Ametop™ caused less vasoconstriction and facilitated easier cannulation. Its use as a topical anesthetic agent is recommended, especially when iv access may be problematic. Objectif Un mélange eutectique d’anesthésiques locaux (MEAL) est souvent utilisé pour l’anesthésie topique lors d’une canulation intraveineuse (iv). La vasoconstriction, qui est l’un des effets secondaires du MEAL, peut compliquer la mise en place d’une canule. Une présentation en gel d’améthocaïne (Ametop™) est maintenant offerte dans le commerce. Le but de la présente étude était de comparer le MEAL et l’Ametop™ en regard du degré d’anesthésie topique fourni, de l’incidence de la vasoconstriction et de la facilité de la canulation iv. Méthode: On a inséré, en deux occasions séparées chez 32 volontaires adultes d’état physique ASA 1, une canuleiv de calibre 16 en utilisant en double aveugle le MEAL et Ametop™ pour réaliser l’anesthésie topique. Après chaque canulation, on a enregistré les paramètres suivants: les scores de douleur à l’échelle visuelle analogue (EVA), la présence de vasoconstriction et la facilité de canulation notée 1 = facile, 2 = modérément difficile, 3 = difficile et 4 = impossible. Résultats Les scores moyens à l’EVA ± l’écart type ont été de 12 ± 9,9 à la suite de la canulation avec Ametop™ M et de 25,3 ± 16,6 après le MEAL (P = 0,002). La vasoconstriction est survenue en 17 occasions après l’application du MEAL et deux fois plus souvent après Ametop™ (P = 0,001). Le degré de difficulté de canulation a été de 1,44 ± 0,88 après le MEAL et de 1,06 ± 0,25 après Ametop™ (P = 0,023). Conclusion La canulation intraveineuse est moins douloureuse après l’application d’Ametop™ que celle du MEAL. De plus, l’Ametop™ a provoqué moins de vasoconstriction et a facilité l’introduction d’une canule. Son usage comme anesthésique topique est recommandé, surtout lorsqu’une action rapide est nécessaire ou que l’accèsiv peut être problématique.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/8274074" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2132fec38fc88ef61b380fb8a1c466a7" rel="nofollow" data-download="{"attachment_id":48159050,"asset_id":8274074,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48159050/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16399742" href="https://ucc-ie.academia.edu/RobertPlant">Robert Plant</a><script data-card-contents-for-user="16399742" type="text/json">{"id":16399742,"first_name":"Robert","last_name":"Plant","domain_name":"ucc-ie","page_name":"RobertPlant","display_name":"Robert Plant","profile_url":"https://ucc-ie.academia.edu/RobertPlant?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_8274074 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="8274074"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 8274074, container: ".js-paper-rank-work_8274074", }); 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$(".js-view-count[data-work-id=8274074]").text(description); $(".js-view-count-work_8274074").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_8274074").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="8274074"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="56615" rel="nofollow" href="https://www.academia.edu/Documents/in/Canadian">Canadian</a>, <script data-card-contents-for-ri="56615" type="text/json">{"id":56615,"name":"Canadian","url":"https://www.academia.edu/Documents/in/Canadian?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="204388" rel="nofollow" href="https://www.academia.edu/Documents/in/Vasoconstriction">Vasoconstriction</a>, <script data-card-contents-for-ri="204388" type="text/json">{"id":204388,"name":"Vasoconstriction","url":"https://www.academia.edu/Documents/in/Vasoconstriction?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=8274074]'), work: {"id":8274074,"title":"Topical amethocaine (Ametop™) is superior to EMLA for intravenous cannulation","created_at":"2014-09-10T07:36:09.454-07:00","url":"https://www.academia.edu/8274074/Topical_amethocaine_Ametop_is_superior_to_EMLA_for_intravenous_cannulation?f_ri=244814","dom_id":"work_8274074","summary":"Purpose A eutectic mixture of local anesthetics (EMLA) is commonly used to provide topical anesthesia for intravenous (iv) cannulation. One of its side effects is vasoconstriction, which may render cannulation more difficult. A gel formulation of amethocaine (Ametop™) is now commercially available. The aim of this study was to compare EMLA and Ametop™ with regard to the degree of topical anesthesia afforded, the incidence of vasoconstriction and the ease of iv cannulation. Methods Thirty two ASA 1 adult volunteers had a # 16 gauge iv cannula inserted on two separate occasions using EMLA and Ametop™ applied in a double blind fashion for topical anesthesia. Parameters that were recorded after each cannulation included visual analogue pain scores (VAPS), the presence of vasoconstriction and the ease of cannulation, graded as: 1 = easy, 2 = moderately difficult, 3 = difficult and 4 = failed. Results The mean VAPS ± SD after cannulation with Ametop™ M was 12 ± 9.9 and with EMLA was 25.3 ± 16.6 (P = 0.002). Vasoconstriction occurred after EMLA application on 17 occasions and twice after Ametop™ (P = 0.001). The grade of difficulty of cannulation was 1.44 ± 0.88 following EMLA and 1.06 ± 0.25 with Ametop™ (P = 0.023). Conclusions Intravenous cannulation was less painful following application of Ametop™ than EMLA. In addition, Ametop™ caused less vasoconstriction and facilitated easier cannulation. Its use as a topical anesthetic agent is recommended, especially when iv access may be problematic. Objectif Un mélange eutectique d’anesthésiques locaux (MEAL) est souvent utilisé pour l’anesthésie topique lors d’une canulation intraveineuse (iv). La vasoconstriction, qui est l’un des effets secondaires du MEAL, peut compliquer la mise en place d’une canule. Une présentation en gel d’améthocaïne (Ametop™) est maintenant offerte dans le commerce. Le but de la présente étude était de comparer le MEAL et l’Ametop™ en regard du degré d’anesthésie topique fourni, de l’incidence de la vasoconstriction et de la facilité de la canulation iv. Méthode: On a inséré, en deux occasions séparées chez 32 volontaires adultes d’état physique ASA 1, une canuleiv de calibre 16 en utilisant en double aveugle le MEAL et Ametop™ pour réaliser l’anesthésie topique. Après chaque canulation, on a enregistré les paramètres suivants: les scores de douleur à l’échelle visuelle analogue (EVA), la présence de vasoconstriction et la facilité de canulation notée 1 = facile, 2 = modérément difficile, 3 = difficile et 4 = impossible. Résultats Les scores moyens à l’EVA ± l’écart type ont été de 12 ± 9,9 à la suite de la canulation avec Ametop™ M et de 25,3 ± 16,6 après le MEAL (P = 0,002). La vasoconstriction est survenue en 17 occasions après l’application du MEAL et deux fois plus souvent après Ametop™ (P = 0,001). Le degré de difficulté de canulation a été de 1,44 ± 0,88 après le MEAL et de 1,06 ± 0,25 après Ametop™ (P = 0,023). Conclusion La canulation intraveineuse est moins douloureuse après l’application d’Ametop™ que celle du MEAL. De plus, l’Ametop™ a provoqué moins de vasoconstriction et a facilité l’introduction d’une canule. Son usage comme anesthésique topique est recommandé, surtout lorsqu’une action rapide est nécessaire ou que l’accèsiv peut être problématique.","downloadable_attachments":[{"id":48159050,"asset_id":8274074,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":16399742,"first_name":"Robert","last_name":"Plant","domain_name":"ucc-ie","page_name":"RobertPlant","display_name":"Robert Plant","profile_url":"https://ucc-ie.academia.edu/RobertPlant?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":56615,"name":"Canadian","url":"https://www.academia.edu/Documents/in/Canadian?f_ri=244814","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=244814","nofollow":true},{"id":204388,"name":"Vasoconstriction","url":"https://www.academia.edu/Documents/in/Vasoconstriction?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":375078,"name":"Topical Drug Administration","url":"https://www.academia.edu/Documents/in/Topical_Drug_Administration?f_ri=244814"},{"id":468993,"name":"Lidocaine","url":"https://www.academia.edu/Documents/in/Lidocaine?f_ri=244814"},{"id":698785,"name":"Side Effect","url":"https://www.academia.edu/Documents/in/Side_Effect?f_ri=244814"},{"id":1558760,"name":"Tetracaine","url":"https://www.academia.edu/Documents/in/Tetracaine?f_ri=244814"},{"id":1558817,"name":"Prilocaine","url":"https://www.academia.edu/Documents/in/Prilocaine?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22802462" data-work_id="22802462" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22802462/Effectiveness_and_cost_effectiveness_of_Davanloos_intensive_short_term_dynamic_psychotherapy_does_unlocking_the_unconscious_make_a_difference">Effectiveness and cost effectiveness of Davanloo's intensive short-term dynamic psychotherapy: does unlocking the unconscious make a difference?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">More than 20 years ago Habib Davanloo coined the term unlocking of the unconscious to describe how the psychodynamic concept of the human unconscious can become accessible using the technique of Intensive Short-Term Dynamic Psychotherapy... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22802462" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">More than 20 years ago Habib Davanloo coined the term unlocking of the unconscious to describe how the psychodynamic concept of the human unconscious can become accessible using the technique of Intensive Short-Term Dynamic Psychotherapy (ISTDP). According to Davanloo, the possibility that unconscious material will be revealed is greatly increased when therapeutic efforts promote dominance of the unconscious therapeutic alliance over unconscious resistance. When these ingredients are present there is a psychic shift that allows unacceptable painful feelings to come to the surface. Toward adding further empirical support for the concept, in this article we compare outcomes between patients who experienced one or more major unlocking of the unconscious (N = 57) to those who did not experience major unlocking (N = 32) during ISTDP treatment. Significant and widespread differences were seen between these two groups, those with major unlocking had greater symptom reduction, interpersonal...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22802462" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="055b128af9d69cea86c7708172a090f4" rel="nofollow" data-download="{"attachment_id":43353378,"asset_id":22802462,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43353378/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44450648" href="https://independent.academia.edu/AAbbass1">A. 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According to Davanloo, the possibility that unconscious material will be revealed is greatly increased when therapeutic efforts promote dominance of the unconscious therapeutic alliance over unconscious resistance. When these ingredients are present there is a psychic shift that allows unacceptable painful feelings to come to the surface. Toward adding further empirical support for the concept, in this article we compare outcomes between patients who experienced one or more major unlocking of the unconscious (N = 57) to those who did not experience major unlocking (N = 32) during ISTDP treatment. Significant and widespread differences were seen between these two groups, those with major unlocking had greater symptom reduction, interpersonal...","downloadable_attachments":[{"id":43353378,"asset_id":22802462,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44450648,"first_name":"A.","last_name":"Abbass","domain_name":"independent","page_name":"AAbbass1","display_name":"A. 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BDD is characterized by excessive preoccupation with one or more perceived defect(s) or flaw(s) in physical appearance which are not... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_62500395" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dermatologists are increasingly confronted with patients affected by body dysmorphic disorder (BDD). BDD is characterized by excessive preoccupation with one or more perceived defect(s) or flaw(s) in physical appearance which are not observable or appear slight to others. So far, there have been only few studies examining the prevalence of BDD in dermatological outpatients. In addition, the need for psychotherapeutic support in dermatological outpatients with body dysmorphic concerns has not yet been systematically examined. The objective of the present study was therefore to investigate the frequency of body dysmorphic concerns as well as social adaptation and the need for psychotherapeutic support in the aforementioned patient group. A total of 252 dermatological outpatients seen at a German university hospital were consecutively enrolled, and examined using the Dysmorphic Concerns Questionnaire, the Social Adaptation Self-Evaluation Scale, and the German version of the University...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/62500395" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b2c1af96fb5eeb4fa47d94bda1469405" rel="nofollow" data-download="{"attachment_id":75272087,"asset_id":62500395,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75272087/download_file?st=MTczOTgwMTA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33515705" href="https://uni-frankfurt.academia.edu/ViktoriaRitter">Viktoria Ritter</a><script data-card-contents-for-user="33515705" type="text/json">{"id":33515705,"first_name":"Viktoria","last_name":"Ritter","domain_name":"uni-frankfurt","page_name":"ViktoriaRitter","display_name":"Viktoria Ritter","profile_url":"https://uni-frankfurt.academia.edu/ViktoriaRitter?f_ri=244814","photo":"https://0.academia-photos.com/33515705/69116212/57509902/s65_viktoria.ritter.jpg"}</script></span></span></li><li class="js-paper-rank-work_62500395 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="62500395"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 62500395, container: ".js-paper-rank-work_62500395", }); 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BDD is characterized by excessive preoccupation with one or more perceived defect(s) or flaw(s) in physical appearance which are not observable or appear slight to others. So far, there have been only few studies examining the prevalence of BDD in dermatological outpatients. In addition, the need for psychotherapeutic support in dermatological outpatients with body dysmorphic concerns has not yet been systematically examined. The objective of the present study was therefore to investigate the frequency of body dysmorphic concerns as well as social adaptation and the need for psychotherapeutic support in the aforementioned patient group. A total of 252 dermatological outpatients seen at a German university hospital were consecutively enrolled, and examined using the Dysmorphic Concerns Questionnaire, the Social Adaptation Self-Evaluation Scale, and the German version of the University...","downloadable_attachments":[{"id":75272087,"asset_id":62500395,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33515705,"first_name":"Viktoria","last_name":"Ritter","domain_name":"uni-frankfurt","page_name":"ViktoriaRitter","display_name":"Viktoria Ritter","profile_url":"https://uni-frankfurt.academia.edu/ViktoriaRitter?f_ri=244814","photo":"https://0.academia-photos.com/33515705/69116212/57509902/s65_viktoria.ritter.jpg"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=244814","nofollow":true},{"id":46406,"name":"Motivation","url":"https://www.academia.edu/Documents/in/Motivation?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=244814","nofollow":true},{"id":378991,"name":"Outpatients","url":"https://www.academia.edu/Documents/in/Outpatients?f_ri=244814"},{"id":2486603,"name":"Surveys and Questionnaires","url":"https://www.academia.edu/Documents/in/Surveys_and_Questionnaires?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_65472713" data-work_id="65472713" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/65472713/Head_injury_in_very_young_children_Mechanisms_injury_types_and_ophthalmologic_findings_in_100_hospitalized_patients_younger_than_2_years_of_age">Head injury in very young children: Mechanisms, injury types, and ophthalmologic findings in 100 hospitalized patients younger than 2 years of age</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/65472713" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4d07fbb748cb874947146ebe82dfda67" rel="nofollow" data-download="{"attachment_id":77054045,"asset_id":65472713,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77054045/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35094454" href="https://independent.academia.edu/DBudenz">D. 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Budenz","profile_url":"https://independent.academia.edu/DBudenz?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=244814","nofollow":true},{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=244814","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=244814","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=244814","nofollow":true},{"id":91079,"name":"Child Abuse","url":"https://www.academia.edu/Documents/in/Child_Abuse?f_ri=244814"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=244814"},{"id":368876,"name":"Head injury","url":"https://www.academia.edu/Documents/in/Head_injury?f_ri=244814"},{"id":1159940,"name":"Cerebral Hemorrhage","url":"https://www.academia.edu/Documents/in/Cerebral_Hemorrhage?f_ri=244814"},{"id":1902100,"name":"Biomechanical Phenomena","url":"https://www.academia.edu/Documents/in/Biomechanical_Phenomena?f_ri=244814"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=244814"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences?f_ri=244814"},{"id":3761707,"name":"Accidental falls","url":"https://www.academia.edu/Documents/in/Accidental_falls?f_ri=244814"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=244814"},{"id":4002452,"name":"Accidents Traffic","url":"https://www.academia.edu/Documents/in/Accidents_Traffic?f_ri=244814"},{"id":4022567,"name":"Brain concussion","url":"https://www.academia.edu/Documents/in/Brain_concussion?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28780938" data-work_id="28780938" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28780938/Intracytoplasmic_sperm_injection_by_testicular_sperm_in_patients_with_aspermia_or_azoospermia_after_cancer_treatment">Intracytoplasmic sperm injection by testicular sperm in patients with aspermia or azoospermia after cancer treatment</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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href="https://www.academia.edu/Documents/in/Andrology">Andrology</a>, <script data-card-contents-for-ri="654" type="text/json">{"id":654,"name":"Andrology","url":"https://www.academia.edu/Documents/in/Andrology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="29423" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer_treatment">Cancer treatment</a>, <script data-card-contents-for-ri="29423" type="text/json">{"id":29423,"name":"Cancer treatment","url":"https://www.academia.edu/Documents/in/Cancer_treatment?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31837" rel="nofollow" href="https://www.academia.edu/Documents/in/Cell_separation">Cell separation</a><script data-card-contents-for-ri="31837" type="text/json">{"id":31837,"name":"Cell separation","url":"https://www.academia.edu/Documents/in/Cell_separation?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28780938]'), work: {"id":28780938,"title":"Intracytoplasmic sperm injection by testicular sperm in patients with aspermia or azoospermia after cancer 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treatment","url":"https://www.academia.edu/Documents/in/Cancer_treatment?f_ri=244814","nofollow":true},{"id":31837,"name":"Cell separation","url":"https://www.academia.edu/Documents/in/Cell_separation?f_ri=244814","nofollow":true},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=244814"},{"id":98929,"name":"Intracytoplasmic Sperm Injection","url":"https://www.academia.edu/Documents/in/Intracytoplasmic_Sperm_Injection?f_ri=244814"},{"id":203521,"name":"tESTIS","url":"https://www.academia.edu/Documents/in/tESTIS?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=244814"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=244814"},{"id":862371,"name":"Spermatozoa","url":"https://www.academia.edu/Documents/in/Spermatozoa?f_ri=244814"},{"id":999436,"name":"Female Infertility","url":"https://www.academia.edu/Documents/in/Female_Infertility?f_ri=244814"},{"id":1043331,"name":"Semen Preservation","url":"https://www.academia.edu/Documents/in/Semen_Preservation?f_ri=244814"},{"id":1355491,"name":"Pregnancy Outcome","url":"https://www.academia.edu/Documents/in/Pregnancy_Outcome?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22839514" data-work_id="22839514" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22839514/Cryopreservation_of_human_spermatozoa_Comparison_of_two_cryopreservation_methods_and_three_cryoprotectants">Cryopreservation of human spermatozoa: Comparison of two cryopreservation methods and three cryoprotectants</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: To evaluate the ability of two cryopreservation methods and three cryoprotectants to preserve sperm quality. Design: A prospective clinical study. Setting: Male infertility clinic at a tertiary healthcare center. Patient(s):... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22839514" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: To evaluate the ability of two cryopreservation methods and three cryoprotectants to preserve sperm quality. Design: A prospective clinical study. Setting: Male infertility clinic at a tertiary healthcare center. Patient(s): Twenty infertile men and 10 healthy donors. Intervention(s): In the first experiment, semen was cryopreserved by either the Irvine Scientific method (IS) or the Cleveland Clinic Foundation (CCF) method. In the second experiment, semen was cryopreserved by the IS method and one of three cryoprotectants: TES and Tris yolk buffer, Sperm Freezing Medium, or Enhance Sperm Freeze. Main Outcome Measure(s): Postthaw sperm motility, cryosurvival, and kinematics. Result(s): Percentages of postthaw sperm motility and cryosurvival were higher in the IS cryopreservation method compared with in the CCF method (15.94 Ϯ 9.19 vs. 12.07 Ϯ 7. 31 and 47.42 Ϯ 17.44 vs. 35.76 Ϯ 17.56). However, the CCF method resulted in significantly better sperm kinematics. Postthaw motility in the donors and patients was highest in the samples frozen in TES and Tris yolk buffer medium.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22839514" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6775969510f1b380556dbc29f8439296" rel="nofollow" data-download="{"attachment_id":43384279,"asset_id":22839514,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43384279/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44494217" href="https://liverpool.academia.edu/NabilAziz">Nabil Aziz</a><script data-card-contents-for-user="44494217" type="text/json">{"id":44494217,"first_name":"Nabil","last_name":"Aziz","domain_name":"liverpool","page_name":"NabilAziz","display_name":"Nabil Aziz","profile_url":"https://liverpool.academia.edu/NabilAziz?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22839514 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22839514"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22839514, container: ".js-paper-rank-work_22839514", }); 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$(".js-view-count[data-work-id=22839514]").text(description); $(".js-view-count-work_22839514").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22839514").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22839514"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="19295" rel="nofollow" href="https://www.academia.edu/Documents/in/Cryopreservation">Cryopreservation</a>, <script data-card-contents-for-ri="19295" type="text/json">{"id":19295,"name":"Cryopreservation","url":"https://www.academia.edu/Documents/in/Cryopreservation?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="98922" rel="nofollow" href="https://www.academia.edu/Documents/in/Fertility_and_Sterility">Fertility and Sterility</a>, <script data-card-contents-for-ri="98922" type="text/json">{"id":98922,"name":"Fertility and Sterility","url":"https://www.academia.edu/Documents/in/Fertility_and_Sterility?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22839514]'), work: {"id":22839514,"title":"Cryopreservation of human spermatozoa: Comparison of two cryopreservation methods and three cryoprotectants","created_at":"2016-03-05T03:05:50.763-08:00","url":"https://www.academia.edu/22839514/Cryopreservation_of_human_spermatozoa_Comparison_of_two_cryopreservation_methods_and_three_cryoprotectants?f_ri=244814","dom_id":"work_22839514","summary":"Objective: To evaluate the ability of two cryopreservation methods and three cryoprotectants to preserve sperm quality. Design: A prospective clinical study. Setting: Male infertility clinic at a tertiary healthcare center. Patient(s): Twenty infertile men and 10 healthy donors. Intervention(s): In the first experiment, semen was cryopreserved by either the Irvine Scientific method (IS) or the Cleveland Clinic Foundation (CCF) method. In the second experiment, semen was cryopreserved by the IS method and one of three cryoprotectants: TES and Tris yolk buffer, Sperm Freezing Medium, or Enhance Sperm Freeze. Main Outcome Measure(s): Postthaw sperm motility, cryosurvival, and kinematics. Result(s): Percentages of postthaw sperm motility and cryosurvival were higher in the IS cryopreservation method compared with in the CCF method (15.94 Ϯ 9.19 vs. 12.07 Ϯ 7. 31 and 47.42 Ϯ 17.44 vs. 35.76 Ϯ 17.56). However, the CCF method resulted in significantly better sperm kinematics. Postthaw motility in the donors and patients was highest in the samples frozen in TES and Tris yolk buffer medium.","downloadable_attachments":[{"id":43384279,"asset_id":22839514,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44494217,"first_name":"Nabil","last_name":"Aziz","domain_name":"liverpool","page_name":"NabilAziz","display_name":"Nabil Aziz","profile_url":"https://liverpool.academia.edu/NabilAziz?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":19295,"name":"Cryopreservation","url":"https://www.academia.edu/Documents/in/Cryopreservation?f_ri=244814","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=244814","nofollow":true},{"id":98922,"name":"Fertility and Sterility","url":"https://www.academia.edu/Documents/in/Fertility_and_Sterility?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=244814"},{"id":897073,"name":"Sperm Motility","url":"https://www.academia.edu/Documents/in/Sperm_Motility?f_ri=244814"},{"id":963536,"name":"Sperm Count","url":"https://www.academia.edu/Documents/in/Sperm_Count?f_ri=244814"},{"id":1043331,"name":"Semen Preservation","url":"https://www.academia.edu/Documents/in/Semen_Preservation?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16666127" data-work_id="16666127" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16666127/Radiculopathy_in_degenerative_lumbar_scoliosis_treatment_with_selective_nerve_root_steroid_injections">Radiculopathy in degenerative lumbar scoliosis: treatment with selective nerve root steroid injections</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective To define the origin of radiculopathy of patients with degenerative lumbar scoliosis and to assess the correlation between percentage of radiculating pain relief with selective nerve root injections and lateral canal dimensions.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16666127" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective To define the origin of radiculopathy of patients with degenerative lumbar scoliosis and to assess the correlation between percentage of radiculating pain relief with selective nerve root injections and lateral canal dimensions. Methods Ninety-three consecutive ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16666127" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="18b6a3f854b49f6102c189de755ab524" rel="nofollow" data-download="{"attachment_id":42419261,"asset_id":16666127,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42419261/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36031074" href="https://independent.academia.edu/FrancisDenis1">Francis Denis</a><script data-card-contents-for-user="36031074" type="text/json">{"id":36031074,"first_name":"Francis","last_name":"Denis","domain_name":"independent","page_name":"FrancisDenis1","display_name":"Francis Denis","profile_url":"https://independent.academia.edu/FrancisDenis1?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16666127 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16666127"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16666127, container: ".js-paper-rank-work_16666127", }); });</script></li><li class="js-percentile-work_16666127 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16666127; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16666127"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16666127 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16666127"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16666127; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16666127]").text(description); $(".js-view-count-work_16666127").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16666127").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16666127"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="457827" rel="nofollow" href="https://www.academia.edu/Documents/in/Scoliosis">Scoliosis</a><script data-card-contents-for-ri="457827" type="text/json">{"id":457827,"name":"Scoliosis","url":"https://www.academia.edu/Documents/in/Scoliosis?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16666127]'), work: {"id":16666127,"title":"Radiculopathy in degenerative lumbar scoliosis: treatment with selective nerve root steroid injections","created_at":"2015-10-11T12:15:16.346-07:00","url":"https://www.academia.edu/16666127/Radiculopathy_in_degenerative_lumbar_scoliosis_treatment_with_selective_nerve_root_steroid_injections?f_ri=244814","dom_id":"work_16666127","summary":"Objective To define the origin of radiculopathy of patients with degenerative lumbar scoliosis and to assess the correlation between percentage of radiculating pain relief with selective nerve root injections and lateral canal dimensions. Methods Ninety-three consecutive ...","downloadable_attachments":[{"id":42419261,"asset_id":16666127,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36031074,"first_name":"Francis","last_name":"Denis","domain_name":"independent","page_name":"FrancisDenis1","display_name":"Francis Denis","profile_url":"https://independent.academia.edu/FrancisDenis1?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":457827,"name":"Scoliosis","url":"https://www.academia.edu/Documents/in/Scoliosis?f_ri=244814","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24007674 coauthored" data-work_id="24007674" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24007674/Core_and_thenar_skin_temperature_variation_during_prolonged_abdominal_surgery_comparison_of_two_sites_of_active_forced_air_warming">Core and thenar skin temperature variation during prolonged abdominal surgery: comparison of two sites of active forced air warming</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: This study was designed to compare the efficacy of two different sites of active forced air warming, upper body or lower body, to maintain normothermia; and their respective effect on thenar skin temperature in relation to the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24007674" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: This study was designed to compare the efficacy of two different sites of active forced air warming, upper body or lower body, to maintain normothermia; and their respective effect on thenar skin temperature in relation to the accelerographic monitoring of neuromuscular blockade during longlasting abdominal surgery. Methods: Twenty-six patients were randomised into two groups: upper body, (nΩ13) and lower body, (nΩ13), for intraoperative forced air warming. General anaesthesia was induced with thiopentone, sufentanil, and maintained with a mixture of N 2 O/O 2 /isoflurane. Pancuronium, 0.1 mg ¡ kg ª1 was used to facilitate tracheal intubation. Reinjection doses of 0.01 mg ¡ kg ª1 were administered once 25% recovery of first twitch height of train-of-four stimulation had occurred, or if surgical relaxation was estimated as inadequate by the surgeon. Thenar skin temperature and core temperature were monitored continuously. Results: A similar trend for core temperature profile was observed in both groups. After an initial mild hypothermia, normothermia was reached progressively. Normothermia was obtained faster with lower body forced air warming than with upper body (2 h versus 3 h), PϽ0.05. Thenar skin temperature</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24007674" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ed08fe63ab6da33379131d0dd1ffaeb9" rel="nofollow" data-download="{"attachment_id":44390409,"asset_id":24007674,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44390409/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46356149" href="https://independent.academia.edu/CyrusMotamed">Cyrus Motamed</a><script data-card-contents-for-user="46356149" type="text/json">{"id":46356149,"first_name":"Cyrus","last_name":"Motamed","domain_name":"independent","page_name":"CyrusMotamed","display_name":"Cyrus Motamed","profile_url":"https://independent.academia.edu/CyrusMotamed?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-24007674">+1</span><div class="hidden js-additional-users-24007674"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/ThierryLabaille">Thierry Labaille</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-24007674'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-24007674').html(); 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and their respective effect on thenar skin temperature in relation to the accelerographic monitoring of neuromuscular blockade during longlasting abdominal surgery. Methods: Twenty-six patients were randomised into two groups: upper body, (nΩ13) and lower body, (nΩ13), for intraoperative forced air warming. General anaesthesia was induced with thiopentone, sufentanil, and maintained with a mixture of N 2 O/O 2 /isoflurane. Pancuronium, 0.1 mg ¡ kg ª1 was used to facilitate tracheal intubation. Reinjection doses of 0.01 mg ¡ kg ª1 were administered once 25% recovery of first twitch height of train-of-four stimulation had occurred, or if surgical relaxation was estimated as inadequate by the surgeon. Thenar skin temperature and core temperature were monitored continuously. Results: A similar trend for core temperature profile was observed in both groups. After an initial mild hypothermia, normothermia was reached progressively. Normothermia was obtained faster with lower body forced air warming than with upper body (2 h versus 3 h), PϽ0.05. Thenar skin temperature","downloadable_attachments":[{"id":44390409,"asset_id":24007674,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":46356149,"first_name":"Cyrus","last_name":"Motamed","domain_name":"independent","page_name":"CyrusMotamed","display_name":"Cyrus Motamed","profile_url":"https://independent.academia.edu/CyrusMotamed?f_ri=244814","photo":"/images/s65_no_pic.png"},{"id":72494977,"first_name":"Thierry","last_name":"Labaille","domain_name":"independent","page_name":"ThierryLabaille","display_name":"Thierry Labaille","profile_url":"https://independent.academia.edu/ThierryLabaille?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814","nofollow":true},{"id":426463,"name":"ACTA","url":"https://www.academia.edu/Documents/in/ACTA?f_ri=244814","nofollow":true},{"id":826123,"name":"Abdominal Surgery","url":"https://www.academia.edu/Documents/in/Abdominal_Surgery?f_ri=244814"},{"id":976256,"name":"Skin Temperature","url":"https://www.academia.edu/Documents/in/Skin_Temperature?f_ri=244814"},{"id":995334,"name":"Neuromuscular Junction","url":"https://www.academia.edu/Documents/in/Neuromuscular_Junction?f_ri=244814"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=244814"},{"id":1491514,"name":"*Hot Temperature","url":"https://www.academia.edu/Documents/in/_Hot_Temperature?f_ri=244814"},{"id":1653983,"name":"Abdomen","url":"https://www.academia.edu/Documents/in/Abdomen?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17889915 coauthored" data-work_id="17889915" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17889915/A_model_preclinical_clinical_and_graduate_educational_curriculum_in_emergency_medicine_for_medical_students_and_rotating_residents">A model preclinical, clinical, and graduate educational curriculum in emergency medicine for medical students and rotating residents</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item 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class="hidden js-additional-users-17889915"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/BenHonigman">Ben Honigman</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-17889915'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-17889915').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_17889915 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17889915"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17889915, container: ".js-paper-rank-work_17889915", }); });</script></li><li class="js-percentile-work_17889915 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span 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data-has-card-for-ri="2622" rel="nofollow" href="https://www.academia.edu/Documents/in/Graduate_Education">Graduate Education</a>, <script data-card-contents-for-ri="2622" type="text/json">{"id":2622,"name":"Graduate Education","url":"https://www.academia.edu/Documents/in/Graduate_Education?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44057" rel="nofollow" href="https://www.academia.edu/Documents/in/Curriculum">Curriculum</a>, <script data-card-contents-for-ri="44057" type="text/json">{"id":44057,"name":"Curriculum","url":"https://www.academia.edu/Documents/in/Curriculum?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62445" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Students">Medical Students</a><script data-card-contents-for-ri="62445" type="text/json">{"id":62445,"name":"Medical 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Schafermeyer","profile_url":"https://independent.academia.edu/RobertSchafermeyer?f_ri=244814","photo":"/images/s65_no_pic.png"},{"id":38397642,"first_name":"Ben","last_name":"Honigman","domain_name":"independent","page_name":"BenHonigman","display_name":"Ben Honigman","profile_url":"https://independent.academia.edu/BenHonigman?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":607,"name":"Emergency Medicine","url":"https://www.academia.edu/Documents/in/Emergency_Medicine?f_ri=244814","nofollow":true},{"id":2622,"name":"Graduate Education","url":"https://www.academia.edu/Documents/in/Graduate_Education?f_ri=244814","nofollow":true},{"id":44057,"name":"Curriculum","url":"https://www.academia.edu/Documents/in/Curriculum?f_ri=244814","nofollow":true},{"id":62445,"name":"Medical Students","url":"https://www.academia.edu/Documents/in/Medical_Students?f_ri=244814","nofollow":true},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=244814"},{"id":99364,"name":"Undergraduate medical education","url":"https://www.academia.edu/Documents/in/Undergraduate_medical_education?f_ri=244814"},{"id":163322,"name":"Graduate medical education","url":"https://www.academia.edu/Documents/in/Graduate_medical_education?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1251656" data-work_id="1251656" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1251656/A_group_music_intervention_using_percussion_instruments_with_familiar_music_to_reduce_anxiety_and_agitation_of_institutionalized_older_adults_with_dementia">A group music intervention using percussion instruments with familiar music to reduce anxiety and agitation of institutionalized older adults with dementia</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1251656" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a53f9bd3df024e9d487b79da5917632c" rel="nofollow" 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href="https://www.academia.edu/54352801/Can_cost_utility_evaluations_inform_decision_making_about_interventions_for_low_back_pain">Can cost utility evaluations inform decision making about interventions for low back pain?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">BACKGROUND CONTEXT: Low back pain (LBP) is associated with high health-care utilization and lost productivity. Numerous interventions are routinely used, although few are supported by strong evidence. Cost utility analyses (CUAs) may be... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_54352801" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">BACKGROUND CONTEXT: Low back pain (LBP) is associated with high health-care utilization and lost productivity. Numerous interventions are routinely used, although few are supported by strong evidence. Cost utility analyses (CUAs) may be helpful to inform decision makers. PURPOSE: To conduct a systematic review of CUAs of interventions for LBP. STUDY DESIGN: Systematic review. METHODS: A search strategy combining medical subject headings and free text related to LBP and health economic evaluations was executed in MEDLINE. Cost utility analyses combined with randomized controlled trials for LBP were included. Studies that were published before 1998, non-English, decision analyses, and duplicate reports were excluded. Search results were evaluated by two reviewers, who extracted data independently related to clinical study design, economic study design, direct cost components, utility results, cost results, and CUA results. RESULTS: The search produced 319 citations, and of these 15 met eligibility criteria. Most were from the United Kingdom (n58), published in the past 3 years (n512), studied chronic LBP or radiculopathy (n513), and had a follow-up O12 months (n513). Combined, there were 33 study groups who received a mean 2.1 interventions, most commonly education (n517), exercise therapy (n513), spinal manipulation therapy (n57), surgery (n57), and usual care from a general practitioner (n57). Mean baseline utility was 0.57, improving to 0.67 at follow-up; the mean difference in utility improvement between study groups was 0.04.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/54352801" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ca6e619a1eafcfe3ab4af645f63e24b1" rel="nofollow" data-download="{"attachment_id":70758040,"asset_id":54352801,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70758040/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39707556" href="https://independent.academia.edu/ScottHaldeman">Scott Haldeman</a><script data-card-contents-for-user="39707556" type="text/json">{"id":39707556,"first_name":"Scott","last_name":"Haldeman","domain_name":"independent","page_name":"ScottHaldeman","display_name":"Scott Haldeman","profile_url":"https://independent.academia.edu/ScottHaldeman?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_54352801 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="54352801"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 54352801, container: ".js-paper-rank-work_54352801", }); 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Numerous interventions are routinely used, although few are supported by strong evidence. Cost utility analyses (CUAs) may be helpful to inform decision makers. PURPOSE: To conduct a systematic review of CUAs of interventions for LBP. STUDY DESIGN: Systematic review. METHODS: A search strategy combining medical subject headings and free text related to LBP and health economic evaluations was executed in MEDLINE. Cost utility analyses combined with randomized controlled trials for LBP were included. Studies that were published before 1998, non-English, decision analyses, and duplicate reports were excluded. Search results were evaluated by two reviewers, who extracted data independently related to clinical study design, economic study design, direct cost components, utility results, cost results, and CUA results. RESULTS: The search produced 319 citations, and of these 15 met eligibility criteria. Most were from the United Kingdom (n58), published in the past 3 years (n512), studied chronic LBP or radiculopathy (n513), and had a follow-up O12 months (n513). Combined, there were 33 study groups who received a mean 2.1 interventions, most commonly education (n517), exercise therapy (n513), spinal manipulation therapy (n57), surgery (n57), and usual care from a general practitioner (n57). Mean baseline utility was 0.57, improving to 0.67 at follow-up; the mean difference in utility improvement between study groups was 0.04.","downloadable_attachments":[{"id":70758040,"asset_id":54352801,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39707556,"first_name":"Scott","last_name":"Haldeman","domain_name":"independent","page_name":"ScottHaldeman","display_name":"Scott Haldeman","profile_url":"https://independent.academia.edu/ScottHaldeman?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1292,"name":"Health Economics","url":"https://www.academia.edu/Documents/in/Health_Economics?f_ri=244814","nofollow":true},{"id":1681,"name":"Decision Making","url":"https://www.academia.edu/Documents/in/Decision_Making?f_ri=244814","nofollow":true},{"id":4531,"name":"Clinical 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class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/33719249/Classical_and_model_based_estimates_of_beta_cell_function_during_a_mixed_meal_vs_an_OGTT_in_a_population_based_cohort">Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">d i a b e t e s r e s e a r c h a n d c l i n i c a l p r a c t i c e 8 3 ( 2 0 0 9 ) 2 8 0 -2 8 8</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33719249" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" 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href="https://www.academia.edu/Documents/in/Food">Food</a>, <script data-card-contents-for-ri="7603" type="text/json">{"id":7603,"name":"Food","url":"https://www.academia.edu/Documents/in/Food?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="16682" rel="nofollow" href="https://www.academia.edu/Documents/in/Mathematical_Modelling">Mathematical Modelling</a>, <script data-card-contents-for-ri="16682" type="text/json">{"id":16682,"name":"Mathematical Modelling","url":"https://www.academia.edu/Documents/in/Mathematical_Modelling?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51373" rel="nofollow" href="https://www.academia.edu/Documents/in/Insulin_Resistance">Insulin Resistance</a><script data-card-contents-for-ri="51373" type="text/json">{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33719249]'), work: {"id":33719249,"title":"Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort","created_at":"2017-06-30T10:34:07.611-07:00","url":"https://www.academia.edu/33719249/Classical_and_model_based_estimates_of_beta_cell_function_during_a_mixed_meal_vs_an_OGTT_in_a_population_based_cohort?f_ri=244814","dom_id":"work_33719249","summary":"d i a b e t e s r e s e a r c h a n d c l i n i c a l p r a c t i c e 8 3 ( 2 0 0 9 ) 2 8 0 -2 8 8","downloadable_attachments":[{"id":53715699,"asset_id":33719249,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32419154,"first_name":"Marjan","last_name":"Alssema","domain_name":"independent","page_name":"MarjanAlssema","display_name":"Marjan Alssema","profile_url":"https://independent.academia.edu/MarjanAlssema?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4581,"name":"Diabetes","url":"https://www.academia.edu/Documents/in/Diabetes?f_ri=244814","nofollow":true},{"id":7603,"name":"Food","url":"https://www.academia.edu/Documents/in/Food?f_ri=244814","nofollow":true},{"id":16682,"name":"Mathematical Modelling","url":"https://www.academia.edu/Documents/in/Mathematical_Modelling?f_ri=244814","nofollow":true},{"id":51373,"name":"Insulin 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Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814"},{"id":697540,"name":"Oral Glucose Tolerance Test","url":"https://www.academia.edu/Documents/in/Oral_Glucose_Tolerance_Test?f_ri=244814"},{"id":901298,"name":"Glucose Tolerance Test","url":"https://www.academia.edu/Documents/in/Glucose_Tolerance_Test?f_ri=244814"},{"id":1423006,"name":"General Population","url":"https://www.academia.edu/Documents/in/General_Population?f_ri=244814"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17867232" data-work_id="17867232" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17867232/Perioperative_Complications_of_the_Agility_Total_Ankle_Replacement_in_50_Initial_Consecutive_Cases">Perioperative Complications of the Agility Total Ankle Replacement in 50 Initial, Consecutive Cases</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Although functional and clinical outcomes after total ankle arthroplasty have been promising, a steep learning curve has been recognized. In addition, the performance of concomitant hindfoot realignment procedures is controversial. The... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17867232" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Although functional and clinical outcomes after total ankle arthroplasty have been promising, a steep learning curve has been recognized. In addition, the performance of concomitant hindfoot realignment procedures is controversial. The purpose of this study was to report on a single surgeon&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s experience with the first 50 total ankle arthroplasty procedures. We wanted to define the characteristics of the learning curve and whether the rate of complications was increased in patients who required complex reconstruction for preexistent foot and ankle deformities. This was a retrospective study of 50 cases with an average follow-up of 24.2 months. The patient population consisted of 18 men and 30 women with an average age of 57.6 years. Twenty-six percent of the cases had concomitant bony realignment procedures, while 20% had prior history of major hindfoot corrective procedures. There were 19 cases with intraoperative malleolar fractures, 12 cases that exhibited some degree of malalignment, and 6 cases of syndesmotic nonunion, and 8 ankles required early component revision. Minor wound complications that resolved with local wound care occurred in 9 cases, while 1 patient had a major wound complication requiring flap coverage. Each of these complications, other than wound complications, decreased with the surgeon&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s experience. Our results also indicate that the performance of major realignment procedures at the same time of implant arthroplasty is not associated with an increased incidence of complications. The results of this study suggest that total ankle arthroplasty is associated with a learning curve. Perioperative complications may potentially decrease with surgeon experience.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17867232" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="66cac770a08b057fc60558a6f266de62" rel="nofollow" data-download="{"attachment_id":42221688,"asset_id":17867232,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42221688/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37779072" href="https://independent.academia.edu/JohnSchuberth">John Schuberth</a><script data-card-contents-for-user="37779072" type="text/json">{"id":37779072,"first_name":"John","last_name":"Schuberth","domain_name":"independent","page_name":"JohnSchuberth","display_name":"John Schuberth","profile_url":"https://independent.academia.edu/JohnSchuberth?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17867232 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17867232"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17867232, container: ".js-paper-rank-work_17867232", }); 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$(".js-view-count[data-work-id=17867232]").text(description); $(".js-view-count-work_17867232").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17867232").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17867232"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="40210" rel="nofollow" href="https://www.academia.edu/Documents/in/Foot_and_Ankle_Surgery">Foot and Ankle Surgery</a>, <script data-card-contents-for-ri="40210" type="text/json">{"id":40210,"name":"Foot and Ankle Surgery","url":"https://www.academia.edu/Documents/in/Foot_and_Ankle_Surgery?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="191096" rel="nofollow" href="https://www.academia.edu/Documents/in/Arthritis">Arthritis</a>, <script data-card-contents-for-ri="191096" type="text/json">{"id":191096,"name":"Arthritis","url":"https://www.academia.edu/Documents/in/Arthritis?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" rel="nofollow" href="https://www.academia.edu/Documents/in/Aged">Aged</a><script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17867232]'), work: {"id":17867232,"title":"Perioperative Complications of the Agility Total Ankle Replacement in 50 Initial, Consecutive Cases","created_at":"2015-11-06T08:17:52.670-08:00","url":"https://www.academia.edu/17867232/Perioperative_Complications_of_the_Agility_Total_Ankle_Replacement_in_50_Initial_Consecutive_Cases?f_ri=244814","dom_id":"work_17867232","summary":"Although functional and clinical outcomes after total ankle arthroplasty have been promising, a steep learning curve has been recognized. In addition, the performance of concomitant hindfoot realignment procedures is controversial. The purpose of this study was to report on a single surgeon\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s experience with the first 50 total ankle arthroplasty procedures. We wanted to define the characteristics of the learning curve and whether the rate of complications was increased in patients who required complex reconstruction for preexistent foot and ankle deformities. This was a retrospective study of 50 cases with an average follow-up of 24.2 months. The patient population consisted of 18 men and 30 women with an average age of 57.6 years. Twenty-six percent of the cases had concomitant bony realignment procedures, while 20% had prior history of major hindfoot corrective procedures. There were 19 cases with intraoperative malleolar fractures, 12 cases that exhibited some degree of malalignment, and 6 cases of syndesmotic nonunion, and 8 ankles required early component revision. Minor wound complications that resolved with local wound care occurred in 9 cases, while 1 patient had a major wound complication requiring flap coverage. Each of these complications, other than wound complications, decreased with the surgeon\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s experience. Our results also indicate that the performance of major realignment procedures at the same time of implant arthroplasty is not associated with an increased incidence of complications. The results of this study suggest that total ankle arthroplasty is associated with a learning curve. Perioperative complications may potentially decrease with surgeon experience.","downloadable_attachments":[{"id":42221688,"asset_id":17867232,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37779072,"first_name":"John","last_name":"Schuberth","domain_name":"independent","page_name":"JohnSchuberth","display_name":"John Schuberth","profile_url":"https://independent.academia.edu/JohnSchuberth?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":40210,"name":"Foot and Ankle Surgery","url":"https://www.academia.edu/Documents/in/Foot_and_Ankle_Surgery?f_ri=244814","nofollow":true},{"id":191096,"name":"Arthritis","url":"https://www.academia.edu/Documents/in/Arthritis?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814","nofollow":true},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=244814"},{"id":740993,"name":"Ankle Joint","url":"https://www.academia.edu/Documents/in/Ankle_Joint?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1423420 coauthored" data-work_id="1423420" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1423420/Which_urgent_care_services_do_febrile_children_use_and_why">Which urgent care services do febrile children use and why?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objectives To explore how parents navigate urgent and emergency care (U&EC) services when their child <5 years old has a feverish illness, their views of that experience and whether services are meeting their needs and triaging in line... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_1423420" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objectives To explore how parents navigate urgent and emergency care (U&EC) services when their child <5 years old has a feverish illness, their views of that experience and whether services are meeting their needs and triaging in line with national guidance. Design Parents of a febrile child <5 years old contacting any U&EC service in three localities during a 6-month period were invited to participate in a telephone questionnaire supplemented by case note review. A subset participated in an in-depth interview. Results Of 556 parents expressing an interest, 220 enrolled, making 570 contacts (median 3, range 1-13) with services during the child's illness which lasted 3 days on average. Parents' fi rst preference for advice in hours was to see a general practitioner (GP) (67%; 93/138) and when unavailable, National Health Service Direct (46%; 38/82). 155 made more than one contact and 63% of the repeat contacts were initiated by a service provider. A range of factors infl uenced parents' use of services. Parents who reported receiving 'safety netting' advice (81%) were less likely to re-present to U&EC services than those who did not recall receiving such advice (35% vs 52%, p=0.01). Parents identifi ed a need for accurate, consistent, written advice regarding fever and antipyretics. Conclusion Parents know the U&EC service options available, and their fi rst choice is the GP. Multiple contacts are being made for relatively well children, often due to repeated referrals within the system. Safety netting advice reduces re-attendances but parents want explicit and consistent advice for appropriate home management.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1423420" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7e5c0a1a7d4390c04b86f2f90ed940bf" rel="nofollow" data-download="{"attachment_id":50976313,"asset_id":1423420,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50976313/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="665981" href="https://independent.academia.edu/SirkkaKomulainen">Sirkka Komulainen</a><script data-card-contents-for-user="665981" type="text/json">{"id":665981,"first_name":"Sirkka","last_name":"Komulainen","domain_name":"independent","page_name":"SirkkaKomulainen","display_name":"Sirkka Komulainen","profile_url":"https://independent.academia.edu/SirkkaKomulainen?f_ri=244814","photo":"https://0.academia-photos.com/665981/233026/20215277/s65_sirkka.komulainen.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-1423420">+1</span><div class="hidden js-additional-users-1423420"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://imperial.academia.edu/IanMaconochie">Ian Maconochie</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-1423420'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-1423420').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_1423420 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1423420"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1423420, container: ".js-paper-rank-work_1423420", }); });</script></li><li class="js-percentile-work_1423420 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 1423420; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_1423420"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_1423420 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="1423420"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 1423420; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=1423420]").text(description); $(".js-view-count-work_1423420").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_1423420").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="1423420"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="25469" rel="nofollow" href="https://www.academia.edu/Documents/in/Family_Practice">Family Practice</a>, <script data-card-contents-for-ri="25469" type="text/json">{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="30494" rel="nofollow" href="https://www.academia.edu/Documents/in/England">England</a>, <script data-card-contents-for-ri="30494" type="text/json">{"id":30494,"name":"England","url":"https://www.academia.edu/Documents/in/England?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51831" rel="nofollow" href="https://www.academia.edu/Documents/in/Information_Services">Information Services</a>, <script data-card-contents-for-ri="51831" type="text/json">{"id":51831,"name":"Information Services","url":"https://www.academia.edu/Documents/in/Information_Services?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="134346" rel="nofollow" href="https://www.academia.edu/Documents/in/Infant">Infant</a><script data-card-contents-for-ri="134346" type="text/json">{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=1423420]'), work: {"id":1423420,"title":"Which urgent care services do febrile children use and why?","created_at":"2012-02-21T20:35:51.949-08:00","url":"https://www.academia.edu/1423420/Which_urgent_care_services_do_febrile_children_use_and_why?f_ri=244814","dom_id":"work_1423420","summary":"Objectives To explore how parents navigate urgent and emergency care (U\u0026EC) services when their child \u003c5 years old has a feverish illness, their views of that experience and whether services are meeting their needs and triaging in line with national guidance. Design Parents of a febrile child \u003c5 years old contacting any U\u0026EC service in three localities during a 6-month period were invited to participate in a telephone questionnaire supplemented by case note review. A subset participated in an in-depth interview. Results Of 556 parents expressing an interest, 220 enrolled, making 570 contacts (median 3, range 1-13) with services during the child's illness which lasted 3 days on average. Parents' fi rst preference for advice in hours was to see a general practitioner (GP) (67%; 93/138) and when unavailable, National Health Service Direct (46%; 38/82). 155 made more than one contact and 63% of the repeat contacts were initiated by a service provider. A range of factors infl uenced parents' use of services. Parents who reported receiving 'safety netting' advice (81%) were less likely to re-present to U\u0026EC services than those who did not recall receiving such advice (35% vs 52%, p=0.01). Parents identifi ed a need for accurate, consistent, written advice regarding fever and antipyretics. Conclusion Parents know the U\u0026EC service options available, and their fi rst choice is the GP. Multiple contacts are being made for relatively well children, often due to repeated referrals within the system. Safety netting advice reduces re-attendances but parents want explicit and consistent advice for appropriate home management.","downloadable_attachments":[{"id":50976313,"asset_id":1423420,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":665981,"first_name":"Sirkka","last_name":"Komulainen","domain_name":"independent","page_name":"SirkkaKomulainen","display_name":"Sirkka Komulainen","profile_url":"https://independent.academia.edu/SirkkaKomulainen?f_ri=244814","photo":"https://0.academia-photos.com/665981/233026/20215277/s65_sirkka.komulainen.jpg"},{"id":32408070,"first_name":"Ian","last_name":"Maconochie","domain_name":"imperial","page_name":"IanMaconochie","display_name":"Ian Maconochie","profile_url":"https://imperial.academia.edu/IanMaconochie?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=244814","nofollow":true},{"id":30494,"name":"England","url":"https://www.academia.edu/Documents/in/England?f_ri=244814","nofollow":true},{"id":51831,"name":"Information Services","url":"https://www.academia.edu/Documents/in/Information_Services?f_ri=244814","nofollow":true},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=244814","nofollow":true},{"id":180897,"name":"National Health Service","url":"https://www.academia.edu/Documents/in/National_Health_Service?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=244814"},{"id":303598,"name":"Parents","url":"https://www.academia.edu/Documents/in/Parents?f_ri=244814"},{"id":382710,"name":"System Safety","url":"https://www.academia.edu/Documents/in/System_Safety?f_ri=244814"},{"id":387144,"name":"Fever","url":"https://www.academia.edu/Documents/in/Fever?f_ri=244814"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=244814"},{"id":466522,"name":"General practitioner","url":"https://www.academia.edu/Documents/in/General_practitioner?f_ri=244814"},{"id":727158,"name":"Hotlines","url":"https://www.academia.edu/Documents/in/Hotlines?f_ri=244814"},{"id":908186,"name":"Service Provider","url":"https://www.academia.edu/Documents/in/Service_Provider?f_ri=244814"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects?f_ri=244814"},{"id":1453350,"name":"Ambulatory Care","url":"https://www.academia.edu/Documents/in/Ambulatory_Care?f_ri=244814"},{"id":1529835,"name":"Choice Behavior","url":"https://www.academia.edu/Documents/in/Choice_Behavior?f_ri=244814"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=244814"},{"id":2529977,"name":"attitude to health","url":"https://www.academia.edu/Documents/in/attitude_to_health?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20132581" data-work_id="20132581" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20132581/Comparison_of_two_versions_of_the_Vigileo_FloTracTM_system_1_03_and_1_07_for_stroke_volume_estimation_a_multicentre_blinded_comparison_with_oesophageal_Doppler_measurements">Comparison of two versions of the Vigileo-FloTracTM system (1.03 and 1.07) for stroke volume estimation: a multicentre, blinded comparison with oesophageal Doppler measurements</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Background. Our aim was to evaluate the validity of stroke volume measurements obtained using the Vigileo-FloTrac TM system in comparison with those obtained using oesophageal Doppler considered as a reference.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20132581" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="af0000f819ed60ff2ace2bbedd285068" rel="nofollow" data-download="{"attachment_id":41225493,"asset_id":20132581,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41225493/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41208943" href="https://independent.academia.edu/StephaneRudnicki">Stephane Rudnicki</a><script data-card-contents-for-user="41208943" type="text/json">{"id":41208943,"first_name":"Stephane","last_name":"Rudnicki","domain_name":"independent","page_name":"StephaneRudnicki","display_name":"Stephane Rudnicki","profile_url":"https://independent.academia.edu/StephaneRudnicki?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20132581 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20132581"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20132581, container: ".js-paper-rank-work_20132581", }); 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$(".js-view-count[data-work-id=20132581]").text(description); $(".js-view-count-work_20132581").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20132581").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20132581"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="53293" rel="nofollow" href="https://www.academia.edu/Documents/in/Software">Software</a>, <script data-card-contents-for-ri="53293" type="text/json">{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="74347" rel="nofollow" href="https://www.academia.edu/Documents/in/Hemodynamics">Hemodynamics</a>, <script data-card-contents-for-ri="74347" type="text/json">{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="94234" rel="nofollow" href="https://www.academia.edu/Documents/in/INTENSIVE_CARE">INTENSIVE CARE</a><script data-card-contents-for-ri="94234" type="text/json">{"id":94234,"name":"INTENSIVE CARE","url":"https://www.academia.edu/Documents/in/INTENSIVE_CARE?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20132581]'), work: {"id":20132581,"title":"Comparison of two versions of the Vigileo-FloTracTM system (1.03 and 1.07) for stroke volume estimation: a multicentre, blinded comparison with oesophageal Doppler measurements","created_at":"2016-01-10T01:58:40.803-08:00","url":"https://www.academia.edu/20132581/Comparison_of_two_versions_of_the_Vigileo_FloTracTM_system_1_03_and_1_07_for_stroke_volume_estimation_a_multicentre_blinded_comparison_with_oesophageal_Doppler_measurements?f_ri=244814","dom_id":"work_20132581","summary":"Background. Our aim was to evaluate the validity of stroke volume measurements obtained using the Vigileo-FloTrac TM system in comparison with those obtained using oesophageal Doppler considered as a reference.","downloadable_attachments":[{"id":41225493,"asset_id":20132581,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41208943,"first_name":"Stephane","last_name":"Rudnicki","domain_name":"independent","page_name":"StephaneRudnicki","display_name":"Stephane Rudnicki","profile_url":"https://independent.academia.edu/StephaneRudnicki?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=244814","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=244814","nofollow":true},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=244814","nofollow":true},{"id":94234,"name":"INTENSIVE CARE","url":"https://www.academia.edu/Documents/in/INTENSIVE_CARE?f_ri=244814","nofollow":true},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814"},{"id":601516,"name":"Flow Velocity","url":"https://www.academia.edu/Documents/in/Flow_Velocity?f_ri=244814"},{"id":647820,"name":"Fluid Therapy","url":"https://www.academia.edu/Documents/in/Fluid_Therapy?f_ri=244814"},{"id":1157501,"name":"Blood Flow Velocity","url":"https://www.academia.edu/Documents/in/Blood_Flow_Velocity?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17091793 coauthored" data-work_id="17091793" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17091793/Cor_Triatriatum_Presentation_Diagnosis_and_Long_Term_Surgical_Results">Cor Triatriatum: Presentation, Diagnosis and Long-Term Surgical Results</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cor triatriatum sinister is a rare, surgically correctable, congenital cardiac anomaly. Fewer than 250 cases have been reported. It can occur as an isolated defect (classic) or in association with other congenital cardiac anomalies... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17091793" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cor triatriatum sinister is a rare, surgically correctable, congenital cardiac anomaly. Fewer than 250 cases have been reported. It can occur as an isolated defect (classic) or in association with other congenital cardiac anomalies (atypical).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17091793" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9d01640e06071209e5f78d0531e954ad" rel="nofollow" data-download="{"attachment_id":42324999,"asset_id":17091793,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42324999/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36665161" href="https://independent.academia.edu/NelsonAlphonso">Nelson Alphonso</a><script data-card-contents-for-user="36665161" type="text/json">{"id":36665161,"first_name":"Nelson","last_name":"Alphonso","domain_name":"independent","page_name":"NelsonAlphonso","display_name":"Nelson Alphonso","profile_url":"https://independent.academia.edu/NelsonAlphonso?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-17091793">+1</span><div class="hidden js-additional-users-17091793"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/ChristianBrizard">Christian Brizard</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-17091793'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-17091793').html(); 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Fewer than 250 cases have been reported. It can occur as an isolated defect (classic) or in association with other congenital cardiac anomalies (atypical).","downloadable_attachments":[{"id":42324999,"asset_id":17091793,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36665161,"first_name":"Nelson","last_name":"Alphonso","domain_name":"independent","page_name":"NelsonAlphonso","display_name":"Nelson Alphonso","profile_url":"https://independent.academia.edu/NelsonAlphonso?f_ri=244814","photo":"/images/s65_no_pic.png"},{"id":48209113,"first_name":"Christian","last_name":"Brizard","domain_name":"independent","page_name":"ChristianBrizard","display_name":"Christian Brizard","profile_url":"https://independent.academia.edu/ChristianBrizard?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=244814","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=244814","nofollow":true},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=244814"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=244814"},{"id":1953423,"name":"Postoperative Period","url":"https://www.academia.edu/Documents/in/Postoperative_Period?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30306681" data-work_id="30306681" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30306681/A_Possible_Role_of_the_Thalamus_in_Some_Cases_of_Sudden_Unexpected_Death_in_Epilepsy">A Possible Role of the Thalamus in Some Cases of Sudden Unexpected Death in Epilepsy</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30306681" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a5891d87f0a70a1ea596f8997da23041" rel="nofollow" data-download="{"attachment_id":50764315,"asset_id":30306681,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50764315/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="57682210" href="https://unifesp.academia.edu/RicardoMarioArida">Ricardo Mario Arida</a><script data-card-contents-for-user="57682210" type="text/json">{"id":57682210,"first_name":"Ricardo Mario","last_name":"Arida","domain_name":"unifesp","page_name":"RicardoMarioArida","display_name":"Ricardo Mario Arida","profile_url":"https://unifesp.academia.edu/RicardoMarioArida?f_ri=244814","photo":"https://0.academia-photos.com/57682210/177534927/167601981/s65_ricardo_mario.arida.jpeg"}</script></span></span></li><li class="js-paper-rank-work_30306681 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30306681"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30306681, container: ".js-paper-rank-work_30306681", }); 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$(".js-view-count[data-work-id=30306681]").text(description); $(".js-view-count-work_30306681").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_30306681").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="30306681"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="59748" rel="nofollow" href="https://www.academia.edu/Documents/in/Sudden_Death">Sudden Death</a>, <script data-card-contents-for-ri="59748" type="text/json">{"id":59748,"name":"Sudden Death","url":"https://www.academia.edu/Documents/in/Sudden_Death?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="66228" rel="nofollow" href="https://www.academia.edu/Documents/in/Thalamus">Thalamus</a>, <script data-card-contents-for-ri="66228" type="text/json">{"id":66228,"name":"Thalamus","url":"https://www.academia.edu/Documents/in/Thalamus?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="228487" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsia">Epilepsia</a><script data-card-contents-for-ri="228487" type="text/json">{"id":228487,"name":"Epilepsia","url":"https://www.academia.edu/Documents/in/Epilepsia?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=30306681]'), work: {"id":30306681,"title":"A Possible Role of the Thalamus in Some Cases of Sudden Unexpected Death in Epilepsy","created_at":"2016-12-07T04:07:49.948-08:00","url":"https://www.academia.edu/30306681/A_Possible_Role_of_the_Thalamus_in_Some_Cases_of_Sudden_Unexpected_Death_in_Epilepsy?f_ri=244814","dom_id":"work_30306681","summary":null,"downloadable_attachments":[{"id":50764315,"asset_id":30306681,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":57682210,"first_name":"Ricardo Mario","last_name":"Arida","domain_name":"unifesp","page_name":"RicardoMarioArida","display_name":"Ricardo Mario Arida","profile_url":"https://unifesp.academia.edu/RicardoMarioArida?f_ri=244814","photo":"https://0.academia-photos.com/57682210/177534927/167601981/s65_ricardo_mario.arida.jpeg"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=244814","nofollow":true},{"id":59748,"name":"Sudden Death","url":"https://www.academia.edu/Documents/in/Sudden_Death?f_ri=244814","nofollow":true},{"id":66228,"name":"Thalamus","url":"https://www.academia.edu/Documents/in/Thalamus?f_ri=244814","nofollow":true},{"id":228487,"name":"Epilepsia","url":"https://www.academia.edu/Documents/in/Epilepsia?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=244814"},{"id":493010,"name":"Sudden Cardiac Death","url":"https://www.academia.edu/Documents/in/Sudden_Cardiac_Death?f_ri=244814"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11020356" data-work_id="11020356" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11020356/Viral_hepatitis_and_HIV_co_infection">Viral hepatitis and HIV co-infection</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Persons at high risk for human immunodeficiency virus (HIV) infection are also likely to be at risk for other infectious pathogens, including hepatitis B virus (HBV) or hepatitis C virus (HCV). These are bloodborne pathogens transmitted... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11020356" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Persons at high risk for human immunodeficiency virus (HIV) infection are also likely to be at risk for other infectious pathogens, including hepatitis B virus (HBV) or hepatitis C virus (HCV). These are bloodborne pathogens transmitted through similar routes; for example, via injection drug use (IDU), sexual contact, or from mother to child during pregnancy or birth. In some settings, the prevalence of coinfection with HBV and/or HCV is high. In the context of effective antiretroviral therapy (ART), liver disease has emerged as a major cause of morbidity and mortality in HIV-infected persons. Further, coinfection with viral hepatitis may complicate the delivery of ART by increasing the risk of drug-related hepatoxicity and impacting the selection of specific agents (e.g., those dually active against HIV and HBV). Expert guidelines developed in the United States and Europe recommend screening of all HIV-infected persons for infection with HCV and HBV and appropriate management of those found to be chronically infected. Treatment strategies for HBV infection include the use of nucleos(t)ide analogues with or without anti-HIV activity and/or peginterferon alfa (PegIFN) whereas HCV treatment is limited to the combination of PegIFN and ribavirin (RBV). Current approaches to management of HIVinfected persons coinfected with HBV or HCV are discussed in this review.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11020356" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2592b4a2909c0c63d997ecece176762f" rel="nofollow" data-download="{"attachment_id":46964106,"asset_id":11020356,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46964106/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="26671935" href="https://independent.academia.edu/josemedrano4">jose medrano</a><script data-card-contents-for-user="26671935" type="text/json">{"id":26671935,"first_name":"jose","last_name":"medrano","domain_name":"independent","page_name":"josemedrano4","display_name":"jose medrano","profile_url":"https://independent.academia.edu/josemedrano4?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11020356 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11020356"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11020356, container: ".js-paper-rank-work_11020356", }); });</script></li><li class="js-percentile-work_11020356 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11020356; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_11020356"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_11020356 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="11020356"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11020356; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11020356]").text(description); $(".js-view-count-work_11020356").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11020356").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11020356"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">23</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6947" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Microbiology">Medical Microbiology</a>, <script data-card-contents-for-ri="6947" type="text/json">{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8942" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment">Treatment</a>, <script data-card-contents-for-ri="8942" type="text/json">{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10640" rel="nofollow" href="https://www.academia.edu/Documents/in/Drug_Discovery">Drug Discovery</a>, <script data-card-contents-for-ri="10640" type="text/json">{"id":10640,"name":"Drug Discovery","url":"https://www.academia.edu/Documents/in/Drug_Discovery?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a><script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11020356]'), work: {"id":11020356,"title":"Viral hepatitis and HIV co-infection","created_at":"2015-02-23T11:05:33.610-08:00","url":"https://www.academia.edu/11020356/Viral_hepatitis_and_HIV_co_infection?f_ri=244814","dom_id":"work_11020356","summary":"Persons at high risk for human immunodeficiency virus (HIV) infection are also likely to be at risk for other infectious pathogens, including hepatitis B virus (HBV) or hepatitis C virus (HCV). These are bloodborne pathogens transmitted through similar routes; for example, via injection drug use (IDU), sexual contact, or from mother to child during pregnancy or birth. In some settings, the prevalence of coinfection with HBV and/or HCV is high. In the context of effective antiretroviral therapy (ART), liver disease has emerged as a major cause of morbidity and mortality in HIV-infected persons. Further, coinfection with viral hepatitis may complicate the delivery of ART by increasing the risk of drug-related hepatoxicity and impacting the selection of specific agents (e.g., those dually active against HIV and HBV). Expert guidelines developed in the United States and Europe recommend screening of all HIV-infected persons for infection with HCV and HBV and appropriate management of those found to be chronically infected. Treatment strategies for HBV infection include the use of nucleos(t)ide analogues with or without anti-HIV activity and/or peginterferon alfa (PegIFN) whereas HCV treatment is limited to the combination of PegIFN and ribavirin (RBV). Current approaches to management of HIVinfected persons coinfected with HBV or HCV are discussed in this review.","downloadable_attachments":[{"id":46964106,"asset_id":11020356,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":26671935,"first_name":"jose","last_name":"medrano","domain_name":"independent","page_name":"josemedrano4","display_name":"jose medrano","profile_url":"https://independent.academia.edu/josemedrano4?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=244814","nofollow":true},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=244814","nofollow":true},{"id":10640,"name":"Drug Discovery","url":"https://www.academia.edu/Documents/in/Drug_Discovery?f_ri=244814","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=244814","nofollow":true},{"id":27385,"name":"Hepatitis C","url":"https://www.academia.edu/Documents/in/Hepatitis_C?f_ri=244814"},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=244814"},{"id":37773,"name":"Hepatology","url":"https://www.academia.edu/Documents/in/Hepatology?f_ri=244814"},{"id":63331,"name":"Hepatitis B","url":"https://www.academia.edu/Documents/in/Hepatitis_B?f_ri=244814"},{"id":82145,"name":"Virus","url":"https://www.academia.edu/Documents/in/Virus?f_ri=244814"},{"id":102583,"name":"Drug Resistance","url":"https://www.academia.edu/Documents/in/Drug_Resistance?f_ri=244814"},{"id":103565,"name":"Viral hepatitis","url":"https://www.academia.edu/Documents/in/Viral_hepatitis?f_ri=244814"},{"id":125176,"name":"Liver Fibrosis","url":"https://www.academia.edu/Documents/in/Liver_Fibrosis?f_ri=244814"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":295458,"name":"Pegylated Interferon","url":"https://www.academia.edu/Documents/in/Pegylated_Interferon?f_ri=244814"},{"id":652845,"name":"Intravenous Drug Users","url":"https://www.academia.edu/Documents/in/Intravenous_Drug_Users?f_ri=244814"},{"id":792401,"name":"Antiviral","url":"https://www.academia.edu/Documents/in/Antiviral?f_ri=244814"},{"id":855510,"name":"Liver Disease","url":"https://www.academia.edu/Documents/in/Liver_Disease?f_ri=244814"},{"id":1198599,"name":"chronic hepatitis B","url":"https://www.academia.edu/Documents/in/chronic_hepatitis_B?f_ri=244814"},{"id":1198617,"name":"chronic hepatitis C","url":"https://www.academia.edu/Documents/in/chronic_hepatitis_C?f_ri=244814"},{"id":1455619,"name":"End Stage Liver Disease","url":"https://www.academia.edu/Documents/in/End_Stage_Liver_Disease?f_ri=244814"},{"id":1622318,"name":"Antiviral Agents","url":"https://www.academia.edu/Documents/in/Antiviral_Agents?f_ri=244814"},{"id":2249317,"name":"Viral Load","url":"https://www.academia.edu/Documents/in/Viral_Load?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26466216" data-work_id="26466216" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26466216/The_systemic_milieu_as_a_mediator_of_dietary_influence_on_stem_cell_function_during_ageing">The systemic milieu as a mediator of dietary influence on stem cell function during ageing</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The regenerative decline of organisms during ageing is linked to the reduced proliferative activity, impaired function and exhaustion of tissue-specific stem and progenitor cells. Studies using heterochronic parabiosis, involving the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_26466216" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The regenerative decline of organisms during ageing is linked to the reduced proliferative activity, impaired function and exhaustion of tissue-specific stem and progenitor cells. Studies using heterochronic parabiosis, involving the surgical attachment of young and old organisms so that they share a common vascular system, have revealed that the systemic environment has a profound effect on stem cell function. In particular, specific youthful rejuvenating circulatory factors reverse age-related declines in stem cell function, whereas the old milieu contains inhibitory factors that impede stem cell function in young animals. Similarly, the effects of certain dietary interventions, namely calorie restriction, also induce a more youthful cellular and molecular phenotype in ageing stem cells throughout the body. Further to this, there are key molecular pathways involved in translating the availability of nutrients into altered stem cell function, including signalling in the insulin and insulin-like growth factor and mechanistic target of rapamycin (mTOR) pathways. In this review, we discuss the potential role of dietary interventions to promote a more rejuvenating systemic milieu in order to enhance stem cell function and promote healthy ageing.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26466216" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="07fb7646eb1e65ecd0009daf0a8bbe5b" rel="nofollow" data-download="{"attachment_id":46760592,"asset_id":26466216,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46760592/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="50421066" href="https://independent.academia.edu/TytusMurphy">Tytus Murphy</a><script data-card-contents-for-user="50421066" type="text/json">{"id":50421066,"first_name":"Tytus","last_name":"Murphy","domain_name":"independent","page_name":"TytusMurphy","display_name":"Tytus Murphy","profile_url":"https://independent.academia.edu/TytusMurphy?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_26466216 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="26466216"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 26466216, container: ".js-paper-rank-work_26466216", }); });</script></li><li class="js-percentile-work_26466216 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26466216; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_26466216"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_26466216 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="26466216"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26466216; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26466216]").text(description); $(".js-view-count-work_26466216").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_26466216").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="26466216"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3642" rel="nofollow" href="https://www.academia.edu/Documents/in/Stem_Cells">Stem Cells</a>, <script data-card-contents-for-ri="3642" type="text/json">{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3851" rel="nofollow" href="https://www.academia.edu/Documents/in/Obesity">Obesity</a>, <script data-card-contents-for-ri="3851" type="text/json">{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4228" rel="nofollow" href="https://www.academia.edu/Documents/in/Skeletal_muscle_biology">Skeletal muscle biology</a>, <script data-card-contents-for-ri="4228" type="text/json">{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6791" rel="nofollow" href="https://www.academia.edu/Documents/in/Aging">Aging</a><script data-card-contents-for-ri="6791" type="text/json">{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=26466216]'), work: {"id":26466216,"title":"The systemic milieu as a mediator of dietary influence on stem cell function during ageing","created_at":"2016-06-24T08:11:03.542-07:00","url":"https://www.academia.edu/26466216/The_systemic_milieu_as_a_mediator_of_dietary_influence_on_stem_cell_function_during_ageing?f_ri=244814","dom_id":"work_26466216","summary":"The regenerative decline of organisms during ageing is linked to the reduced proliferative activity, impaired function and exhaustion of tissue-specific stem and progenitor cells. Studies using heterochronic parabiosis, involving the surgical attachment of young and old organisms so that they share a common vascular system, have revealed that the systemic environment has a profound effect on stem cell function. In particular, specific youthful rejuvenating circulatory factors reverse age-related declines in stem cell function, whereas the old milieu contains inhibitory factors that impede stem cell function in young animals. Similarly, the effects of certain dietary interventions, namely calorie restriction, also induce a more youthful cellular and molecular phenotype in ageing stem cells throughout the body. Further to this, there are key molecular pathways involved in translating the availability of nutrients into altered stem cell function, including signalling in the insulin and insulin-like growth factor and mechanistic target of rapamycin (mTOR) pathways. In this review, we discuss the potential role of dietary interventions to promote a more rejuvenating systemic milieu in order to enhance stem cell function and promote healthy ageing.","downloadable_attachments":[{"id":46760592,"asset_id":26466216,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":50421066,"first_name":"Tytus","last_name":"Murphy","domain_name":"independent","page_name":"TytusMurphy","display_name":"Tytus Murphy","profile_url":"https://independent.academia.edu/TytusMurphy?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells?f_ri=244814","nofollow":true},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity?f_ri=244814","nofollow":true},{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=244814","nofollow":true},{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=244814","nofollow":true},{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=244814"},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=244814"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver?f_ri=244814"},{"id":91391,"name":"mTOR","url":"https://www.academia.edu/Documents/in/mTOR?f_ri=244814"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23776695" data-work_id="23776695" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23776695/Microstructural_and_Functional_Connectivity_in_the_Developing_Preterm_Brain">Microstructural and Functional Connectivity in the Developing Preterm Brain</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Since variations in neural circuitry may influence performance on cognitive tasks, recent... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23776695" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Since variations in neural circuitry may influence performance on cognitive tasks, recent investigations have explored the impact of preterm birth on connectivity in the developing brain. Diffusion tensor imaging studies demonstrate widespread alterations in fractional anisotropy, a measure of axonal integrity and microstructural connectivity, throughout the developing preterm brain. Functional connectivity studies report that preterm neonates, children and adolescents exhibit alterations in both resting state and task-based connectivity when compared to term control subjects. Taken together, these data suggest that neurodevelopmental impairment following preterm birth may represent a disease of neural connectivity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23776695" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1b4ae8d4d78a6c216bff07e670fd5e3c" rel="nofollow" data-download="{"attachment_id":44214518,"asset_id":23776695,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44214518/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5659270" href="https://yale.academia.edu/ToddConstable">Todd Constable</a><script data-card-contents-for-user="5659270" type="text/json">{"id":5659270,"first_name":"Todd","last_name":"Constable","domain_name":"yale","page_name":"ToddConstable","display_name":"Todd Constable","profile_url":"https://yale.academia.edu/ToddConstable?f_ri=244814","photo":"https://0.academia-photos.com/5659270/2460785/2860022/s65_todd.constable.png"}</script></span></span></li><li class="js-paper-rank-work_23776695 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23776695"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23776695, container: ".js-paper-rank-work_23776695", }); });</script></li><li class="js-percentile-work_23776695 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 23776695; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_23776695"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_23776695 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="23776695"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 23776695; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=23776695]").text(description); $(".js-view-count-work_23776695").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23776695").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23776695"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52763" rel="nofollow" href="https://www.academia.edu/Documents/in/Functional_Connectivity">Functional Connectivity</a>, <script data-card-contents-for-ri="52763" type="text/json">{"id":52763,"name":"Functional Connectivity","url":"https://www.academia.edu/Documents/in/Functional_Connectivity?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a>, <script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23776695]'), work: {"id":23776695,"title":"Microstructural and Functional Connectivity in the Developing Preterm Brain","created_at":"2016-03-29T17:37:09.563-07:00","url":"https://www.academia.edu/23776695/Microstructural_and_Functional_Connectivity_in_the_Developing_Preterm_Brain?f_ri=244814","dom_id":"work_23776695","summary":"Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Since variations in neural circuitry may influence performance on cognitive tasks, recent investigations have explored the impact of preterm birth on connectivity in the developing brain. Diffusion tensor imaging studies demonstrate widespread alterations in fractional anisotropy, a measure of axonal integrity and microstructural connectivity, throughout the developing preterm brain. Functional connectivity studies report that preterm neonates, children and adolescents exhibit alterations in both resting state and task-based connectivity when compared to term control subjects. Taken together, these data suggest that neurodevelopmental impairment following preterm birth may represent a disease of neural connectivity.","downloadable_attachments":[{"id":44214518,"asset_id":23776695,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5659270,"first_name":"Todd","last_name":"Constable","domain_name":"yale","page_name":"ToddConstable","display_name":"Todd Constable","profile_url":"https://yale.academia.edu/ToddConstable?f_ri=244814","photo":"https://0.academia-photos.com/5659270/2460785/2860022/s65_todd.constable.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=244814","nofollow":true},{"id":52763,"name":"Functional Connectivity","url":"https://www.academia.edu/Documents/in/Functional_Connectivity?f_ri=244814","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=244814","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=244814","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=244814"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=244814"},{"id":341842,"name":"Seminars","url":"https://www.academia.edu/Documents/in/Seminars?f_ri=244814"},{"id":473797,"name":"Microstructures","url":"https://www.academia.edu/Documents/in/Microstructures?f_ri=244814"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=244814"},{"id":1287048,"name":"Interneurons","url":"https://www.academia.edu/Documents/in/Interneurons?f_ri=244814"},{"id":1399301,"name":"Premature Birth","url":"https://www.academia.edu/Documents/in/Premature_Birth?f_ri=244814"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=244814"},{"id":1765793,"name":"Brain Diseases","url":"https://www.academia.edu/Documents/in/Brain_Diseases?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14244387" data-work_id="14244387" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14244387/Initial_clinical_experience_with_a_remote_magnetic_catheter_navigation_system_for_ablation_of_cavotricuspid_isthmus_dependent_right_atrial_flutter">Initial clinical experience with a remote magnetic catheter navigation system for ablation of cavotricuspid isthmus-dependent right atrial flutter</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A remote magnetic navigation system (MNS) is available and has been used with a 4-mm-tip magnetic catheter for radiofrequency (RF) ablation of some supraventricular and ventricular arrhythmias; however, it has not been evaluated for the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14244387" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A remote magnetic navigation system (MNS) is available and has been used with a 4-mm-tip magnetic catheter for radiofrequency (RF) ablation of some supraventricular and ventricular arrhythmias; however, it has not been evaluated for the ablation of cavotricuspid isthmus-dependent right atrial flutter (AFL). The present study evaluates the feasibility and efficiency of this system and the newly available 8-mm-tip magnetic catheter to perform RF ablation in patients with AFL. Twenty-six consecutive patients (23 men, mean age 64.6 +/- 9.6 years) underwent RF ablation using a remote MNS. RF ablation was performed with an 8-mm-tip magnetic catheter (70 degrees C, maximum power 70 W, 90 seconds). The endpoint of ablation was complete bidirectional isthmus block. To assess a possible learning curve, procedural data were compared between the first 14 (group 1) and the rest (group 2) of the patients. The initial rhythm during ablation was AFL in 20 (19 counterclockwise and 1 clockwise) and s...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14244387" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fca799f878277cd0b732cd75431fc895" rel="nofollow" data-download="{"attachment_id":44411339,"asset_id":14244387,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44411339/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33215043" href="https://independent.academia.edu/ArashArya">Arash Arya</a><script data-card-contents-for-user="33215043" type="text/json">{"id":33215043,"first_name":"Arash","last_name":"Arya","domain_name":"independent","page_name":"ArashArya","display_name":"Arash Arya","profile_url":"https://independent.academia.edu/ArashArya?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14244387 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14244387"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14244387, container: ".js-paper-rank-work_14244387", }); });</script></li><li class="js-percentile-work_14244387 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14244387; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14244387"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14244387 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14244387"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14244387; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14244387]").text(description); $(".js-view-count-work_14244387").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14244387").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14244387"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1131" rel="nofollow" href="https://www.academia.edu/Documents/in/Biomedical_Engineering">Biomedical Engineering</a>, <script data-card-contents-for-ri="1131" type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="100540" rel="nofollow" href="https://www.academia.edu/Documents/in/Feasibility_Studies">Feasibility Studies</a>, <script data-card-contents-for-ri="100540" type="text/json">{"id":100540,"name":"Feasibility Studies","url":"https://www.academia.edu/Documents/in/Feasibility_Studies?f_ri=244814","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14244387]'), work: {"id":14244387,"title":"Initial clinical experience with a remote magnetic catheter navigation system for ablation of cavotricuspid isthmus-dependent right atrial flutter","created_at":"2015-07-20T22:47:13.390-07:00","url":"https://www.academia.edu/14244387/Initial_clinical_experience_with_a_remote_magnetic_catheter_navigation_system_for_ablation_of_cavotricuspid_isthmus_dependent_right_atrial_flutter?f_ri=244814","dom_id":"work_14244387","summary":"A remote magnetic navigation system (MNS) is available and has been used with a 4-mm-tip magnetic catheter for radiofrequency (RF) ablation of some supraventricular and ventricular arrhythmias; however, it has not been evaluated for the ablation of cavotricuspid isthmus-dependent right atrial flutter (AFL). The present study evaluates the feasibility and efficiency of this system and the newly available 8-mm-tip magnetic catheter to perform RF ablation in patients with AFL. Twenty-six consecutive patients (23 men, mean age 64.6 +/- 9.6 years) underwent RF ablation using a remote MNS. RF ablation was performed with an 8-mm-tip magnetic catheter (70 degrees C, maximum power 70 W, 90 seconds). The endpoint of ablation was complete bidirectional isthmus block. To assess a possible learning curve, procedural data were compared between the first 14 (group 1) and the rest (group 2) of the patients. The initial rhythm during ablation was AFL in 20 (19 counterclockwise and 1 clockwise) and s...","downloadable_attachments":[{"id":44411339,"asset_id":14244387,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33215043,"first_name":"Arash","last_name":"Arya","domain_name":"independent","page_name":"ArashArya","display_name":"Arash Arya","profile_url":"https://independent.academia.edu/ArashArya?f_ri=244814","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=244814","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=244814","nofollow":true},{"id":100540,"name":"Feasibility Studies","url":"https://www.academia.edu/Documents/in/Feasibility_Studies?f_ri=244814","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=244814","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=244814"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=244814"},{"id":335874,"name":"Magnetics","url":"https://www.academia.edu/Documents/in/Magnetics?f_ri=244814"},{"id":746571,"name":"Catheter ablation","url":"https://www.academia.edu/Documents/in/Catheter_ablation?f_ri=244814"},{"id":751399,"name":"Atrial Flutter","url":"https://www.academia.edu/Documents/in/Atrial_Flutter?f_ri=244814"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects?f_ri=244814"},{"id":1145520,"name":"Equipment Design","url":"https://www.academia.edu/Documents/in/Equipment_Design?f_ri=244814"},{"id":1157424,"name":"Equipment Failure Analysis","url":"https://www.academia.edu/Documents/in/Equipment_Failure_Analysis?f_ri=244814"},{"id":1295334,"name":"Body Surface Potential Mapping","url":"https://www.academia.edu/Documents/in/Body_Surface_Potential_Mapping?f_ri=244814"},{"id":1330015,"name":"Navigation System","url":"https://www.academia.edu/Documents/in/Navigation_System?f_ri=244814"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30768911" data-work_id="30768911" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30768911/Transpapillary_and_transmural_drainage_of_pancreatic_pseudocysts">Transpapillary and transmural drainage of pancreatic pseudocysts</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Pancreatic pseudocyst endoscopic drainage has been described as a good treatment option, with morbidity and mortality rates that are lower than surgery. The aim of our study is to describe the efficacy of different forms of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_30768911" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Pancreatic pseudocyst endoscopic drainage has been described as a good treatment option, with morbidity and mortality rates that are lower than surgery. The aim of our study is to describe the efficacy of different forms of endoscopic drainage and estimate pseudocyst recurrence rate after short follow up period.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30768911" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a388065bdf843c2a03e0b346ced30c9d" rel="nofollow" data-download="{"attachment_id":51205215,"asset_id":30768911,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51205215/download_file?st=MTczOTgwMTA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="58576642" href="https://independent.academia.edu/HansSeifert1">Hans Seifert</a><script data-card-contents-for-user="58576642" type="text/json">{"id":58576642,"first_name":"Hans","last_name":"Seifert","domain_name":"independent","page_name":"HansSeifert1","display_name":"Hans Seifert","profile_url":"https://independent.academia.edu/HansSeifert1?f_ri=244814","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30768911 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30768911"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30768911, container: ".js-paper-rank-work_30768911", }); 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