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The Story Behind Certis and BarneyOI<sup>\u00ae<\/sup>","entry":"<p>Our origin story begins in 2012 when beloved son, father, avid downhill skier and local celebrity cyclist, James Berglund Junior\u2014known by most as Barney\u2014first complained of nonspecific back pain. Over the next several months, the pain progressively worsened, causing the typically bright-eyed 55-year-old to see his family doctor. In February 2013, computerized tomography (CT) and positron emission tomograph (PET) imaging revealed a large, complex tumor involving Barney\u2019s aorta and multiple abdominal lesions. Biopsy and pathology studies confirmed his rare diagnosis: intermediate grade, soft tissue sarcoma.<\/p>\n<p>A fragment of Barney\u2019s tissue was sent to FoundationOne<sup>\u00ae<\/sup> for genetic sequencing. Six genetic alterations were identified by the molecular profiling panel, but due in part to the relatively low incidence of Barney\u2019s form of cancer, the company\u2019s predictive algorithms were not able to identify a single promising therapy.<\/p>\n","cta":{"title":"see Barney's treatment journey","url":"https:\/\/www.certisoncology.com\/about-us\/barneys-cancer-treatment-journey\/","target":""}}],"media-option":"image","image":{"image":{"ID":4485,"id":4485,"title":"Barney-with-jim-burgland-birthday-2","filename":"Barney-with-jim-burgland-birthday-2.jpg","filesize":90973,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","link":"https:\/\/www.certisoncology.com\/about-us\/our-story\/barney-with-jim-burgland-birthday-2\/","alt":"","author":"6","description":"","caption":"","name":"barney-with-jim-burgland-birthday-2","status":"inherit","uploaded_to":4361,"date":"2022-06-13 18:59:05","modified":"2022-06-13 18:59:05","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":550,"height":410,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","medium-width":300,"medium-height":224,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","medium_large-width":550,"medium_large-height":410,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","large-width":550,"large-height":410,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","1536x1536-width":550,"1536x1536-height":410,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","2048x2048-width":550,"2048x2048-height":410,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2-540x403.jpg","small-width":540,"small-height":403,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2-540x410.jpg","square-sm-width":540,"square-sm-height":410,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","square-md-width":550,"square-md-height":410,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","portrait-width":550,"portrait-height":410,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-2.jpg","landscape-width":550,"landscape-height":410}},"href":"","title":" ","description":"<p><em>Jim Berglund Senior and his son, Barney.<\/em><\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h3>When Standard of Care Fails, What\u2019s Next?<\/h3>\n<p>Shortly after diagnosis, Barney began treatment with standard-of-care systemic therapy. After two cycles of a commonly prescribed combination chemotherapy, a follow-up scan revealed disease progression, prompting his doctors to change strategy in May. Barney underwent multiple cycles of a second-line combination treatment, but his cancer continued to progress. In August, he began third-line therapy, but again he received discouragingly little clinical benefit. Frustrated by the lack of evidence-based options, he pressed doctors for out-of-the-box thinking.<\/p>\n<p>It was about this time that Barney and his parents, James Sr and Mary, first learned about research being conducted at University of California, Los Angeles (UCLA)\u2014physician-scientists evaluating the clinical application of patient-derived xenograft (PDX) models in functional precision oncology.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":4487,"id":4487,"title":"Jim-and-mary-burgland","filename":"Jim-and-mary-burgland.jpg","filesize":63203,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","link":"https:\/\/www.certisoncology.com\/about-us\/our-story\/jim-and-mary-burgland\/","alt":"","author":"6","description":"","caption":"","name":"jim-and-mary-burgland","status":"inherit","uploaded_to":4361,"date":"2022-06-13 18:59:34","modified":"2022-06-13 18:59:34","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":617,"height":472,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","medium-width":300,"medium-height":229,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","medium_large-width":617,"medium_large-height":472,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","large-width":617,"large-height":472,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","1536x1536-width":617,"1536x1536-height":472,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","2048x2048-width":617,"2048x2048-height":472,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland-540x413.jpg","small-width":540,"small-height":413,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland-540x472.jpg","square-sm-width":540,"square-sm-height":472,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","square-md-width":617,"square-md-height":472,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","portrait-width":617,"portrait-height":472,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Jim-and-mary-burgland.jpg","landscape-width":617,"landscape-height":472}},"href":"","title":" ","description":"<p><em>Barney's parents, Mary and Jim Berglund.<\/em><\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e4355bed24 :arr="{"content":"","callout":{"headline":"Orthotopic PDX Models","content":"<p><em>Most PDX models traditionally used in research are developed by implanting cancer cells just below the skin. At Certis, we specialize in orthotopic PDX (O-PDX) models. These are developed by surgically engrafting tumor tissue in the same location from which it occurred in its human counterpart. A significant body of research shows that O-PDX models retain the tumor microenvironment, which is critically important to tumor growth, metastasis and druggability.<\/em><\/p>\n","image":false},"layout":{"background":"cells","style":"card","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h3>Developing Personalized In-Life Mouse Models from Human Tumor Tissue<\/h3>\n<p>These models \u2014 living mouse models of cancer developed from human tumor tissue \u2014 has been shown to be highly representative of their human counterparts. UCLA researchers posited that these models could function as personal avatars for individual patients, enabling the simultaneous testing of multiple therapeutic options in a laboratory setting to help inform personalized, next-line treatment decisions.<\/p>\n<p>In September 2013, Barney was enrolled in a clinical trial aimed at comparing the efficacy of an investigational drug with a commercially available alternative. As part of the trial screening process, he was scheduled for another biopsy. On the day of the procedure, a small fragment of Barney\u2019s tumor tissue was reserved for engraftment into five immunocompromised seed mice\u2014the first step in developing personal PDX models for functional pharmacology testing. Several weeks later, small nodules appeared in the seed mice. By January, they had grown into the dime-sized tumors needed to develop the dozens of PDX models required for pharmacology testing. But time ran short.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":4531,"id":4531,"title":"Certis_preclinical-services-anticancer-therapeutics-bianca","filename":"Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","filesize":96584,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/preclinical-services\/certis_preclinical-services-anticancer-therapeutics-bianca\/","alt":"Certis preclinical services anticancer therapeutics","author":"6","description":"","caption":"","name":"certis_preclinical-services-anticancer-therapeutics-bianca","status":"inherit","uploaded_to":2680,"date":"2022-06-21 15:57:37","modified":"2022-06-21 15:58:00","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":720,"height":632,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","medium-width":300,"medium-height":263,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","medium_large-width":720,"medium_large-height":632,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","large-width":720,"large-height":632,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","1536x1536-width":720,"1536x1536-height":632,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","2048x2048-width":720,"2048x2048-height":632,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca-540x474.jpg","small-width":540,"small-height":474,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca-540x540.jpg","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","square-md-width":720,"square-md-height":632,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca-640x632.jpg","portrait-width":640,"portrait-height":632,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis_preclinical-services-anticancer-therapeutics-bianca.jpg","landscape-width":720,"landscape-height":632}},"href":"","title":" ","description":"<p><em>Personalized orthotopic PDX models\u2014mouse avatars of an individual's cancer\u2014are developed in the laboratory.<\/em><\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h3>Through Loss Comes Life<\/h3>\n<p>Barney\u2019s disease advanced rapidly, and he died in February 2014, just weeks before tumors in his O-PDX models were adequately sized for pharmacology testing.<\/p>\n<p>His family pressed on, determined to do something productive with their grief. Hoping to spare others the kind of anguish only parents can know, Barney\u2019s father, James Berglund Senior, found new purpose in a personal mission to change the decades-long, trial-and-error approach to cancer treatment. He convinced Drs. Fritz Eilber and Arun Singh, two UCLA physician-scientists who treated Barney, to join him. They recruited Peter Ellman, a serial entrepreneur with extensive start-up experience, to lead their new venture.<\/p>\n<p>And in 2016, Certis Oncology Solutions was born.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":4483,"id":4483,"title":"Barney-with-jim-burgland-birthday","filename":"Barney-with-jim-burgland-birthday.jpg","filesize":77570,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","link":"https:\/\/www.certisoncology.com\/about-us\/our-story\/barney-with-jim-burgland-birthday\/","alt":"","author":"6","description":"","caption":"","name":"barney-with-jim-burgland-birthday","status":"inherit","uploaded_to":4361,"date":"2022-06-13 18:54:54","modified":"2022-06-13 18:54:54","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":600,"height":449,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","medium-width":300,"medium-height":225,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","medium_large-width":600,"medium_large-height":449,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","large-width":600,"large-height":449,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","1536x1536-width":600,"1536x1536-height":449,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","2048x2048-width":600,"2048x2048-height":449,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-540x404.jpg","small-width":540,"small-height":404,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday-540x449.jpg","square-sm-width":540,"square-sm-height":449,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","square-md-width":600,"square-md-height":449,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","portrait-width":600,"portrait-height":449,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Barney-with-jim-burgland-birthday.jpg","landscape-width":600,"landscape-height":449}},"href":"","title":" ","description":"<p><em>Barney and his father sharing their birthday celebrations. Barney was born on Jim's birthday.<\/em><\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e44ceb3c3d :arr="{"headline":"","content":"<blockquote>\n<p class=\"x_MsoNormal\">Rare, recurrent, and recalcitrant cancers don\u2019t fit neatly into a predefined medical protocol\u2026 and individuals with cancer simply don\u2019t have time to try multiple therapies to see what works. We established Certis to help oncologists truly individualize each patient\u2019s treatment, and to help optimize each patient\u2019s quality of life.\u201d<\/p>\n<\/blockquote>\n<p><strong>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u2013\u00a0James Berglund Senior<br \/>\n<\/strong>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Chairman of the Board, Certis Oncology Solutions<\/p>\n","featured":{"image":false,"image-href":"","headline":"","description":"","cta":""}}"></component-5f6e44ceb3c3d><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h3>Barney\u2019s Model Is Immortalized<\/h3>\n<p>Today, the tumor model developed from Barney\u2019s tissue lives immortalized in the Certis tumor bank. His tumor model is labeled CRT00395, but to Certis scientists, it\u2019s much more than a number. There\u2019s a name, a face and a personal story behind CRT00395, as there is with each and every patient-derived xenograft (PDX) model in our tumor bank.<\/p>\n<p>The model developed from Barney Berglund\u2019s cancer has a permanent home in our growing collection of tumor models \u2014 all derived from cancer fighters who have consented tumor tissue to research, many of whom have been successfully treated with therapies identified through YourPDX<sup>\u00ae<\/sup> Functional Precision Oncology testing. These tumor models are critical to ongoing cancer research, enabling innovators to develop the next generation of oncology therapeutics.<\/p>\n<p>Each model in the Certis tumor bank is annotated with the patient\u2019s history and deeply characterized with the complex biological and genetic features that made that individual\u2019s cancer unique. Hidden in this and other vast cancer datasets are the answers that will one day realize the promise of precision oncology: connecting every patient to the right therapy, the first time, every time.<\/p>\n<p><a href=\"https:\/\/www.certisoncology.com\/about-us\/barneys-cancer-treatment-journey\/\">Learn more<\/a> about Barney’s cancer treatment journey.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":6599,"id":6599,"title":"Logo_barneyoi-with-icon","filename":"Logo_barneyoi-with-icon-e1708631336792.png","filesize":13703,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/cancer-models-preclinical-studies\/logo_barneyoi-with-icon\/","alt":"","author":"6","description":"","caption":"","name":"logo_barneyoi-with-icon","status":"inherit","uploaded_to":221,"date":"2024-02-07 20:29:24","modified":"2024-02-07 20:29:24","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":445,"height":343,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","medium-width":300,"medium-height":231,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","medium_large-width":445,"medium_large-height":343,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","large-width":445,"large-height":343,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","1536x1536-width":445,"1536x1536-height":343,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","2048x2048-width":445,"2048x2048-height":343,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","small-width":445,"small-height":343,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","square-sm-width":445,"square-sm-height":343,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","square-md-width":445,"square-md-height":343,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","portrait-width":445,"portrait-height":343,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Logo_barneyoi-with-icon-e1708631336792.png","landscape-width":445,"landscape-height":343}},"href":"","title":"The Certis Cancer Model Database","description":"<p>Named for the man and the purpose that inspire us every day, is here to guide the way. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673> </div> <footer> <div class="container"> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="mb-4 mb-md-2 mb-lg-0 mr-sm-4"> <figure class="mb-3 mr-lg-6"> <img class="img-fluid d-block" src="/wp-content/themes/certis/images/certis-logo-lockup-white.svg"> </figure> <address> <div> <span class="street-address d-block">5626 Oberlin Drive, Suite 110</span> <span class="city state zip d-block mb-3">San Diego, CA 92121</span> </div> <div> <span class="phone d-block">Drug Development: 858-988-1033</span> <span class="phone d-block">Patients & Oncologists: 858-228-4110</span> <span class="phone d-block">Main: 858-952-1820</span> </div> </address> </div> <nav 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