In Vivo Pharmacology | Orthotopic Models

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Certis pairs mouse MRI imaging with advanced imaging software to deliver precise, objective tumor volume calculations and measure multiple metastases, as shown in this murine liver. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h2>Increase Translational Relevance<\/h2>\n<ul>\n<li>Targeted focal or whole-body <em>in vivo<\/em> radiation can be used to mimic targeted population treatment history or allow investigation of therapies to be used in conjunction with radiation therapy.<\/li>\n<li>Luciferase-expressing or fluorescent cell lines as well as O-PDX models can localize tumors, quantify tumor growth and metastasis, and monitor tumor response over time.<\/li>\n<li>Using humanized mice and PDX orthotopic engraftment, Certis can evaluate immune response.<\/li>\n<\/ul>\n","cta":{"title":"LEARN MORE","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/custom-model-development\/","target":""}}],"media-option":"image","image":{"image":{"ID":2781,"id":2781,"title":"xrad320","filename":"xrad320.png","filesize":75752,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging\/xrad320\/","alt":"","author":"2","description":"","caption":"","name":"xrad320","status":"inherit","uploaded_to":2686,"date":"2021-06-01 20:48:14","modified":"2021-06-01 20:48:14","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":427,"height":256,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","medium-width":300,"medium-height":180,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","medium_large-width":427,"medium_large-height":256,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","large-width":427,"large-height":256,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","1536x1536-width":427,"1536x1536-height":256,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","2048x2048-width":427,"2048x2048-height":256,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","small-width":427,"small-height":256,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","square-sm-width":427,"square-sm-height":256,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","square-md-width":427,"square-md-height":256,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","portrait-width":427,"portrait-height":256,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/xrad320.png","landscape-width":427,"landscape-height":256}},"href":"","title":"Delivering Precise Radiation Doses","description":"<p>The Precision X-Rad 320 radiator sports a homogeneous beam that delivers a precise radiation dose to either cell cultures or mouse models to prepare them for pharmacology. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e4355bed24 :arr="{"content":"<h2>Context Matters: The Tumor Microenvironment<\/h2>\n<p>When it comes to translational oncology, tumor implantation site matters. While Certis can use traditional legacy models, such as patient derived xenograft subcutaneous mouse models for your IND-enabling studies, patient derived xenograft orthotopic models are preferred to help ensure clinical accuracy.<\/p>\n<p>Subcutaneous PDX is a more widely used and accepted technique than orthotopic PDX. Subcutaneous mouse models can be used as a quick screen \u2014 it is easy to implant patient-derived tumor tissue just beneath the skin and easy to measure tumor growth and treatment response. However, for many different types of cancer, this model fails to metastasize, accurately mimic the tumor microenvironment, or imitate a patient\u2019s clinical treatment response.<span class=\"tooltip\"><sup id=\"3270\">13<\/sup><\/span><\/p>\n<div style=\"text-align: center;\"><img decoding=\"async\" src=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/TEST-conventional-advanced-models-icons.png\" alt=\"\" width=\"65%\" \/><\/div>\n<h3>Improving the Accuracy and Predictive Potential of Cancer Models<\/h3>\n<p>Conventional models like subcutaneous mouse models, are mostly dissimilar from the original tumor both phenotypically and genetically.<span class=\"tooltip\"><sup id=\"3809\">14<\/sup><\/span> Orthotopic models preserve the histological architecture, stoma construction, gene-expression or mutation status of the original tumor tissue, closely replicate the tumor microenvironment, and have been shown to predict the development of resistance and response.<span class=\"tooltip\"><sup id=\"3767\">1<\/sup><\/span><span class=\"tooltip\"><sup id=\"3768\">2<\/sup><\/span><span class=\"tooltip\"><sup id=\"3769\">3<\/sup><\/span><span class=\"tooltip\"><sup id=\"3770\">4<\/sup><\/span><span class=\"tooltip\"><sup id=\"3301\">5<\/sup><\/span><span class=\"tooltip\"><sup id=\"3503\">6<\/sup><\/span><span class=\"tooltip\"><sup id=\"3299\">7<\/sup><\/span><span class=\"tooltip\"><sup id=\"3275\">8<\/sup><\/span><\/p>\n","callout":{"headline":"","content":"","image":false},"layout":{"background":"cells","style":"default","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h2>Consistency is Key: A Matched Pairs Approach<\/h2>\n<p>Proprietary patient-derived xenograft 3D cell cultures can be used for early screening investigations and hypothesis generation. When you are ready, move seamlessly into the matched PDX <em>in vivo<\/em> model, or continue using the PDX-derived cell cultures <em>in vivo<\/em>. A matched pairs approach can reduce variability between early and definitive preclinical studies and may lead to better translation of preclinical data to the clinic. Curious about replicable and reproducible <em>in vitro<\/em> pharmacology and <em>ex vivo<\/em> assays?<\/p>\n","cta":{"title":"LEARN MORE","url":"https:\/\/www.certisoncology.com\/for-drug-developers\/in-vitro-ex-vivo-pharmacology\/","target":""}}],"media-option":"image","image":{"image":{"ID":6191,"id":6191,"title":"In-Vivo_placeholder-1","filename":"In-Vivo_placeholder-1.png","filesize":994653,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1.png","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/in-vivo-pharmacology\/in-vivo_placeholder-1\/","alt":"","author":"6","description":"","caption":"","name":"in-vivo_placeholder-1","status":"inherit","uploaded_to":5914,"date":"2024-01-26 21:52:47","modified":"2024-01-26 21:52:47","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":2824,"height":678,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-720x173.png","medium-width":300,"medium-height":72,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-768x184.png","medium_large-width":768,"medium_large-height":184,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-960x230.png","large-width":960,"large-height":230,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-1536x369.png","1536x1536-width":1536,"1536x1536-height":369,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-2048x492.png","2048x2048-width":2048,"2048x2048-height":492,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-540x130.png","small-width":540,"small-height":130,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-540x540.png","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-720x678.png","square-md-width":720,"square-md-height":678,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-640x678.png","portrait-width":640,"portrait-height":678,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/In-Vivo_placeholder-1-960x640.png","landscape-width":960,"landscape-height":640}},"href":"","title":"In Vitro & In Vivo Conditions Exhibit Concordance","description":"<p>In this proof-of-concept study, PDX-derived 3D cell cultures closely recapitulated the tumor microenvironment and PDX model complexities. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e4355bed24 :arr="{"content":"<h2>Detect Protein Expression on TMAs and FFPE<\/h2>\n<p><span data-contrast=\"auto\">Full necroscopy options including tissue collection, snap freezing, bone marrow collection, blood collection, and optional processing as serum or plasma, Formalin-Fixed Paraffin-Embedded (FFPE)\/Optimal Cutting Temperature (OCT) methods, time collection post-dosing, necropsy observations with photos, tissue measurements, and weight.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n","callout":{"headline":"","content":"","image":false},"layout":{"background":"gray","style":"default","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f6e40ba1bdc4 :arr="{"title":"","content":"","headline":"","items":[{"ID":6162,"post_author":"6","post_date":"2024-01-26 19:49:24","post_date_gmt":"2024-01-26 19:49:24","post_content":"\n<p>With advanced <em>in vivo<\/em> imaging, including bioluminescence imaging, mouse MRI, fluorescence imaging (FLI) techniques, whole body or focal radiation, and more, you can generate reproducible in vivo data about your promising lead compounds. <a href=\"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/\">Learn more<\/a>.<\/p>\n","post_title":"What type of in vivo imaging services do you offer?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-type-of-in-vitro-imaging-services-do-you-offer","to_ping":"","pinged":"","post_modified":"2024-02-16 19:13:04","post_modified_gmt":"2024-02-16 19:13:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6162","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6193,"post_author":"6","post_date":"2024-01-26 21:59:15","post_date_gmt":"2024-01-26 21:59:15","post_content":"\n<p>The size of tumors varies depending on the site and indication.\u202f Most indications we can grow the tumor to 1000mm^3 per our IUCAC protocol.<\/p>\n","post_title":"What size do orthotopically engrafted tumors grow in mice?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-size-do-orthotopically-engrafted-tumors-grow-in-mice","to_ping":"","pinged":"","post_modified":"2024-01-26 21:59:15","post_modified_gmt":"2024-01-26 21:59:15","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6193","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6194,"post_author":"6","post_date":"2024-01-26 22:01:18","post_date_gmt":"2024-01-26 22:01:18","post_content":"\n<p>Timing varies depending on the engraftment site and cancer indication.<\/p>\n","post_title":"How long does it take for orthotopically engrafted tumors to sufficiently grow, so that drug dosing can begin?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-long-does-it-take-for-orthotopically-engrafted-tumors-to-sufficiently-grow-so-that-drug-dosing-can-begin","to_ping":"","pinged":"","post_modified":"2024-01-26 22:01:18","post_modified_gmt":"2024-01-26 22:01:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6194","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6195,"post_author":"6","post_date":"2024-01-26 22:02:35","post_date_gmt":"2024-01-26 22:02:35","post_content":"\n<p>Certis uses a murine-scale MRI\u202fto measure tumor volume in orthotopic models. High-resolution magnetic resonance imaging (MRI) is the gold standard for soft tissue imaging, enabling us to rapidly and precisely measure tumor growth and track metastatic progression. It also allows us to analyze pharmacological responses in real-time\u2014quantitatively and repeatedly, without interfering with the microenvironment or biological processes under study.<\/p>\n","post_title":"How do you measure tumor volume in deep orthotopic locations without interfering with the tumor microenvironment?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-do-you-measure-tumor-volume-in-deep-orthotopic-locations-without-interfering-with-the-tumor-microenvironment","to_ping":"","pinged":"","post_modified":"2024-01-26 22:02:35","post_modified_gmt":"2024-01-26 22:02:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6195","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6196,"post_author":"6","post_date":"2024-01-26 22:05:20","post_date_gmt":"2024-01-26 22:05:20","post_content":"\n<p>The type of mouse strain we use is NOG mice\u202fthat are sourced from North America.<\/p>\n","post_title":"What type of mouse strain do you use?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-type-of-mouse-strain-do-you-use","to_ping":"","pinged":"","post_modified":"2024-01-26 22:05:20","post_modified_gmt":"2024-01-26 22:05:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6196","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6197,"post_author":"6","post_date":"2024-01-26 22:06:13","post_date_gmt":"2024-01-26 22:06:13","post_content":"\n<p>Unlike other cancer artificial intelligence platforms, CertisAI predictions are validated in <em>in vivo<\/em> models \u2014 clinically relevant, well characterized, low passage patient-derived xenografts (PDX) from the BarneyOI Cancer Model Database.<\/p>\n","post_title":"Why do you conduct in vivo validation studies for your cancer artificial intelligence predictions using the CertisAI platform?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"why-do-you-conduct-in-vivo-validation-studies-for-your-cancer-artificial-intelligence-predictions-using-the-certisai-platform","to_ping":"","pinged":"","post_modified":"2024-02-16 19:15:26","post_modified_gmt":"2024-02-16 19:15:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6197","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6198,"post_author":"6","post_date":"2024-01-26 22:07:08","post_date_gmt":"2024-01-26 22:07:08","post_content":"\n<p>Using whole body and focal irradiation, we can develop disease-relevant preclinical models and predictive biomarkers that closely mimic clinical scenarios, including comparing your agent to the standard of care regimen that includes irradiation. Our in-house Precision X-Rad 320 irradiator delivers precision radiation dosage to specific tissues or bodily regions using a homogenous beam. This is further enabled by the X-Rad’s bioluminescent capabilities, to precisely target where tagged tumor cells are located. <\/p>\n\n\n\n<p><a href=\"https:\/\/www.certisoncology.com\/for-drug-developers\/custom-model-development\/\">Learn more<\/a><\/p>\n","post_title":"How do you accurately replicate radiation scenarios in in vivo cancer models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-do-you-accurately-replicate-radiation-scenarios-in-in-vivo-cancer-models","to_ping":"","pinged":"","post_modified":"2024-02-19 20:35:09","post_modified_gmt":"2024-02-19 20:35:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6198","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6199,"post_author":"6","post_date":"2024-01-26 22:08:41","post_date_gmt":"2024-01-26 22:08:41","post_content":"\n<p>Orthotopic PDX models have gained prominence in basic and translational cancer research because they are more clinically relevant than traditional subcutaneous or cell-line-derived PDX models. They preserve the histological architecture, stroma construction, and gene-expression or mutation status of original tumor tissue and they replicate the human tumor microenvironment, which is critical to cancer progression and metastasis. O-PDX models can predict the development of resistance to first-line therapy and response to second-line therapy \u2014 before these events are observed in patients.<\/p>\n","post_title":"What makes patient-derived xenograft orthotopic models better than traditional PDX or CDX models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-makes-patient-derived-xenograft-orthotopic-models-better-than-traditional-pdx-or-cdx-models","to_ping":"","pinged":"","post_modified":"2024-01-26 22:08:41","post_modified_gmt":"2024-01-26 22:08:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6199","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3375,"post_author":"6","post_date":"2021-09-17 19:28:26","post_date_gmt":"2021-09-17 19:28:26","post_content":"\n<p>While PDX orthotopic models have gained prominence in basic and translational oncology research over the last decade, industry continues to rely heavily on subcutaneous PDX mouse models because they are easier to implant and tumors are readily accessible for manual caliper measurement.<sup>1<\/sup> However, manual measurement is inherently prone to variability and inconsistencies introduced by analyst technique and skill. That subjectivity can dramatically influence scientific conclusions.<sup>2 3<\/sup><\/p>\n\n\n\n<p>At Certis, we believe the stakes of preclinical drug development warrant the most clinically relevant models and most precise measurements. That is why we champion the use of orthotopic PDX models for pivotal pharmacology studies and murine-scale MRI for tumor volume measurements.<\/p>\n\n\n\n<p><strong>1<\/strong> Lai Y, Wei X, Lin S, Qin L, Cheng L, Li P. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3998\" target=\"_blank\" rel=\"noreferrer noopener\">Current Status and Perspectives of Patient-Derived Xenograft Models in Cancer Research<\/a>. <em>J Hematol Oncol<\/em>. 2017;10(1):106.<br><strong>2<\/strong> Kersemans V, Cornelissen B, Allen PD, Beech JS, Smart SC. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3799\" target=\"_blank\" rel=\"noreferrer noopener\">Subcutaneous Tumor Volume Measurement in the Awake, Manually Restrained Mouse Using MRI<\/a>. <em>J Magn Reson Imaging<\/em>. 2013;37(6):1499-1504.<br><strong>3<\/strong> Ayers GD, McKinley ET, Zhao P, et al. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#3800\" target=\"_blank\" rel=\"noreferrer noopener\">Volume of Preclinical Xenograft Tumors is More Accurately Assessed by Ultrasound Imaging than Manual Caliper Measurements<\/a>. <em>J Ultrasound Med<\/em>. 2010;29(6):891-901.<\/p>\n","post_title":"If patient-derived xenograft orthotopic models are superior to patient-derived xenograft subcutaneous mouse models, why does the industry still rely so heavily on subcutaneous PDX models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"if-orthotopic-pdx-models-are-superior-to-subcutaneous-pdx-models-why-does-the-industry-still-rely-so-heavily-on-subcutaneous-pdx-models","to_ping":"","pinged":"","post_modified":"2024-02-19 19:59:04","post_modified_gmt":"2024-02-19 19:59:04","post_content_filtered":"","post_parent":3382,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3375","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6201,"post_author":"6","post_date":"2024-01-26 22:13:30","post_date_gmt":"2024-01-26 22:13:30","post_content":"\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"177\" height=\"160\" src=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/AAALAC-image-optimized.webp\" alt=\"\" class=\"wp-image-6203\"\/><\/figure><\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Certis Oncology holds an accreditation from the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International. This voluntary and internationally recognized accreditation reflects the company\u2019s commitment to go beyond standards required by regulatory agencies to achieve excellence in animal care and use. <\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"196\" height=\"133\" src=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/OLAW-image-optimized.webp\" alt=\"\" class=\"wp-image-6205\"\/><\/figure><\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>In addition, Certis Oncology is OLAW-assured. <a href=\"https:\/\/news.certisoncology.com\/certis-oncology-solutions-is-olaw-assured\">Learn more<\/a><\/p>\n\n\n\n<p><\/p>\n","post_title":"How do you ensure the ethical treatment of mice in preclinical studies?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-do-you-ensure-the-ethical-treatment-of-mice-in-preclinical-studies","to_ping":"","pinged":"","post_modified":"2024-01-26 22:41:02","post_modified_gmt":"2024-01-26 22:41:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6201","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6202,"post_author":"6","post_date":"2024-01-26 22:14:37","post_date_gmt":"2024-01-26 22:14:37","post_content":"\n<p>Yes, Certis can custom-develop models of experimental metastasis with advanced orthotopic patient-derived xenografts. Bioluminescence imaging is used to evaluate the ability of tumor cells to arrest, extravasate, and grow in various organs following intravascular injection.<\/p>\n","post_title":"Can you mimic metastases in your orthotopic models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-you-mimic-metastases-in-your-orthotopic-models","to_ping":"","pinged":"","post_modified":"2024-01-26 22:14:37","post_modified_gmt":"2024-01-26 22:14:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6202","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"}],"cta":"","layout":{"background":"","background-offset":""}}"></component-5f6e40ba1bdc4><component-5f7e3c2a849f9 :arr="{"title":"Talk to Us About IND-Enabling Studies Today","description":"<h3 id=\"Enter-your-information\">Enter your information<a 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