Preclinical Imaging & Endpoints | IND-Enabling Studies

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With mouse MRI technology, we can provide high-resolution, 3D whole-body morphological imaging of every animal on study over time to deliver quantitative TVM with unparalleled precision.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":7030,"id":7030,"title":"HTRF-lab-shot-enhanced-optimized","filename":"HTRF-lab-shot-enhanced-optimized.jpg","filesize":56355,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/htrf-lab-shot-enhanced-optimized\/","alt":"","author":"6","description":"","caption":"","name":"htrf-lab-shot-enhanced-optimized","status":"inherit","uploaded_to":5916,"date":"2024-02-22 20:51:08","modified":"2024-02-22 20:51:08","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":550,"height":297,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","medium-width":300,"medium-height":162,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","medium_large-width":550,"medium_large-height":297,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","large-width":550,"large-height":297,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","1536x1536-width":550,"1536x1536-height":297,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","2048x2048-width":550,"2048x2048-height":297,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized-540x292.jpg","small-width":540,"small-height":292,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized-540x297.jpg","square-sm-width":540,"square-sm-height":297,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","square-md-width":550,"square-md-height":297,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","portrait-width":550,"portrait-height":297,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-enhanced-optimized.jpg","landscape-width":550,"landscape-height":297}},"href":"","title":"Mouse MRI Measures Liver Metastasis ","description":"<p>Whole mouse imaging shows multiple metastases in the liver. Certis pairs MRI imaging with advanced imaging software to deliver precise, quantitative TVM.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e3c3648fee :arr="{"headline":"","content":"<h2>Tracking Tumor Burden<\/h2>\n<p>Luciferase bioluminescence imaging and fluorescence imaging are highly sensitive optical imaging techniques that enable efficient and noninvasive ways to localize tumors, quantify tumor growth and metastasis, and monitor tumor response over time. These techniques also may be used for higher-throughput screening, as they allow for rapid and sensitive detection of analytes on multiple animals simultaneously.<\/p>\n<p>An integrated 3D tomography module allows both bioluminescence and fluorescence signals to be reconstructed in 3D and overlaid within a topographical model of the imaging subject. For better understanding of anatomical and deeper tissue structures, the digital organ library allows for superimposition of the mouse organs and bones onto the topographical model.<\/p>\n","cta":"","media-option":"image","image":{"image":{"ID":7413,"id":7413,"title":"BLI Cancer Model","filename":"CRT00295_Metastatic-Cancer-Model-BLI.jpg","filesize":717502,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI.jpg","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/compatibility-plus\/","alt":"Experimental metastasis developed with advanced orthotopic PDX and assessed with BLI to evaluate the ability of tumor cells to arrest, extravasate, and grow in various organs following intravascular injection.","author":"6","description":"Experimental metastasis developed with advanced orthotopic PDX and assessed with BLI to evaluate the ability of tumor cells to arrest, extravasate, and grow in various organs following intravascular injection. ","caption":"","name":"compatibility-plus","status":"inherit","uploaded_to":5916,"date":"2024-06-04 20:20:55","modified":"2024-06-04 20:22:18","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":1403,"height":943,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-720x484.jpg","medium-width":300,"medium-height":202,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-768x516.jpg","medium_large-width":768,"medium_large-height":516,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-960x645.jpg","large-width":960,"large-height":645,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI.jpg","1536x1536-width":1403,"1536x1536-height":943,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI.jpg","2048x2048-width":1403,"2048x2048-height":943,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-540x363.jpg","small-width":540,"small-height":363,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-540x540.jpg","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-720x720.jpg","square-md-width":720,"square-md-height":720,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-640x920.jpg","portrait-width":640,"portrait-height":920,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/CRT00295_Metastatic-Cancer-Model-BLI-960x640.jpg","landscape-width":960,"landscape-height":640}},"href":"","title":"Luciferase Bioluminescence Imaging","description":"<p>Our Vilber NEWTON 7.0 accommodates 8 excitation channels in the Visible (RGB) and Near-Infrared (NIR) spectrums. Signals can be overlaid so that several reporters can be visualized simultaneously in the same animal. A large number of molecular reagents and fluorophores are available.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"left to right","vertical-align":"top"}}"></component-5f6e3c3648fee><component-5f6e3c3648fee :arr="{"headline":"","content":"<h2>Sensitivity, Accuracy, and Economic Efficiency<\/h2>\n<p>MSD is a key biomarker detection methodology that has a higher sensitivity and wider dynamic range compared to other biomarker assay <em>in vitro<\/em> platforms such as ELISA.<\/p>\n","cta":"","media-option":"image","image":{"image":{"ID":7018,"id":7018,"title":"MESO-Scale-Output-reoptimized","filename":"MESO-Scale-Output-reoptimized.png","filesize":183933,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized.png","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/meso-scale-output-reoptimized\/","alt":"","author":"6","description":"","caption":"","name":"meso-scale-output-reoptimized","status":"inherit","uploaded_to":5916,"date":"2024-02-22 20:15:53","modified":"2024-02-22 20:15:53","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":721,"height":519,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized.png","medium-width":300,"medium-height":216,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized.png","medium_large-width":721,"medium_large-height":519,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized.png","large-width":721,"large-height":519,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized.png","1536x1536-width":721,"1536x1536-height":519,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized.png","2048x2048-width":721,"2048x2048-height":519,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized-540x389.png","small-width":540,"small-height":389,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized-540x519.png","square-sm-width":540,"square-sm-height":519,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized.png","square-md-width":720,"square-md-height":518,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized-640x519.png","portrait-width":640,"portrait-height":519,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/MESO-Scale-Output-reoptimized.png","landscape-width":721,"landscape-height":519}},"href":"","title":"MSD Biomarker Assay","description":"<p>Multiplexing using the MSD<sup>\u00ae<\/sup> MESO<sup>\u00ae<\/sup> QuickPlex<sup>\u00ae<\/sup> SQ 120 enables the measurement of native levels of biomarkers in normal and diseased samples without multiple dilutions.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"right to left","vertical-align":"top"}}"></component-5f6e3c3648fee><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h2>Visualizing and Confirming<\/h2>\n<p>Immunohistochemistry (IHC) uses antibody specificity to detect target molecules in cells and tissues. Commonly used as a diagnostic tool to classify tumors according to biomarker expression, IHC also serves as a complementary readout for drug efficacy studies. Certis services include paraffin embedding, conventional to complex immunohistochemical staining, protocol optimization, custom biomarker development, and digital slide-scanning.<\/p>\n<ul>\n<li>H&E (Hemotoxylin and Eosin) to uncover subcellular structural and biochemical components in cell lines or PDX tumors.<\/li>\n<li>Ki-67 protein proliferation marker to determine cellular proliferation and risk of recurrence for certain tumor samples or cell lines.<\/li>\n<li>Custom antibody optimization\/protocol transfer. Have a proprietary antibody for your in-house immunohistochemistry (IHC) assays? Transfer the assay to our scientific team to optimize your protocol.<\/li>\n<\/ul>\n","cta":""}],"media-option":"image","image":{"image":{"ID":6251,"id":6251,"title":"IHC-Output-optimized","filename":"IHC-Output-optimized.webp","filesize":182416,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/ihc-output-optimized\/","alt":"IHC-Output","author":"6","description":"IHC-Output","caption":"IHC-Output","name":"ihc-output-optimized","status":"inherit","uploaded_to":5916,"date":"2024-01-30 23:15:52","modified":"2024-01-30 23:16:00","menu_order":0,"mime_type":"image\/webp","type":"image","subtype":"webp","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":460,"height":243,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized-150x150.webp","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","medium-width":300,"medium-height":158,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","medium_large-width":460,"medium_large-height":243,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","large-width":460,"large-height":243,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","1536x1536-width":460,"1536x1536-height":243,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","2048x2048-width":460,"2048x2048-height":243,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","small-width":460,"small-height":243,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","square-sm-width":460,"square-sm-height":243,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","square-md-width":460,"square-md-height":243,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","portrait-width":460,"portrait-height":243,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/IHC-Output-optimized.webp","landscape-width":460,"landscape-height":243}},"href":"","title":" Comprehensive Histology and IHC Services","description":"<p>Cellular analysis with 3DHISTECH\u2122 PANNORAMIC SCAN II. Ask us which IHC markers and antibodies will be most effective for your preclinical studies today.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e4355bed24 :arr="{"content":"<h2>65+ IHC-Validated Antibodies<\/h2>\n<p><span class=\"NormalTextRun SCXW117481921 BCX0\">Visualize <\/span><span class=\"NormalTextRun SCXW117481921 BCX0\">the <\/span><span class=\"NormalTextRun SCXW117481921 BCX0\">expression and locale <\/span><span class=\"NormalTextRun SCXW117481921 BCX0\">of proteins within tissues <\/span><span class=\"NormalTextRun CommentStart SCXW117481921 BCX0\">with 65+ IHC-validated antibodies<\/span><span class=\"NormalTextRun SCXW117481921 BCX0\">.<\/span> <span class=\"NormalTextRun SCXW117481921 BCX0\">In <\/span><span class=\"NormalTextRun SCXW117481921 BCX0\">the CLIA-certified laboratory, <\/span><span class=\"NormalTextRun SCXW117481921 BCX0\">Certis scientists<\/span> <span class=\"NormalTextRun SCXW117481921 BCX0\">block, cut, stain, and image slides or TMA. <a href=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis-Oncology-IHC-Validated-Antibodies_DP-1.pdf\">DOWNLOAD DATA PACK<\/a><\/span><\/p>\n<p> <\/p>\n<p><a href=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Certis-Oncology-IHC-Validated-Antibodies_DP-1.pdf\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-7310 size-large\" src=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Antibody-Table-1440px-960x706.jpg\" alt=\"Certis Oncology Antibody Table\" width=\"960\" height=\"706\" srcset=\"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Antibody-Table-1440px-960x706.jpg 960w, https:\/\/www.certisoncology.com\/wp-content\/uploads\/Antibody-Table-1440px-720x530.jpg 720w, https:\/\/www.certisoncology.com\/wp-content\/uploads\/Antibody-Table-1440px-768x565.jpg 768w, https:\/\/www.certisoncology.com\/wp-content\/uploads\/Antibody-Table-1440px-540x397.jpg 540w, https:\/\/www.certisoncology.com\/wp-content\/uploads\/Antibody-Table-1440px.jpg 1440w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/><\/a><\/p>\n<h2>Accelerate Your Antibody Discoveries<\/h2>\n<p><span data-contrast=\"none\">See if your target of interest is ready to go with a strategic histology partner.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><span data-contrast=\"none\">Ask us about custom antibody validation for detecting a novel biomarker or target.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p> <\/p>\n","callout":{"headline":"","content":"","image":false},"layout":{"background":"white","style":"default","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h2>Detecting and Quantifying Antibodies<\/h2>\n<p>HTRF for High-Throughput Screening. Homogeneous Time-Resolved Fluorescence (HTRF) is used for the detection and quantification of specific antibodies and other biomarkers. It combines fluorescence resonance energy transfer (FRET) technology with time-resolved (TR) measurement to be an ideal platform for drug target studies used in high-throughput methods.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":7020,"id":7020,"title":"HTRF-lab-shot-reoptimized","filename":"HTRF-lab-shot-reoptimized.png","filesize":357107,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/htrf-lab-shot-reoptimized\/","alt":"","author":"6","description":"","caption":"","name":"htrf-lab-shot-reoptimized","status":"inherit","uploaded_to":5916,"date":"2024-02-22 20:20:15","modified":"2024-02-22 20:20:15","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":550,"height":405,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","medium-width":300,"medium-height":221,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","medium_large-width":550,"medium_large-height":405,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","large-width":550,"large-height":405,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","1536x1536-width":550,"1536x1536-height":405,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","2048x2048-width":550,"2048x2048-height":405,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized-540x398.png","small-width":540,"small-height":398,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized-540x405.png","square-sm-width":540,"square-sm-height":405,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","square-md-width":550,"square-md-height":405,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","portrait-width":550,"portrait-height":405,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/HTRF-lab-shot-reoptimized.png","landscape-width":550,"landscape-height":405}},"href":"","title":"","description":""},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h2>ELISA and High-Performance ECL for Detection and Quantification<\/h2>\n<p>Enzyme-linked immunosorbent assay (ELISA) is a binding, plate-based biochemical assay technique often used to detect and quantify peptides, key protein biomarkers, glycoproteins, enzyme-conjugated antibodies and hormones. Certis offers a 96-well format. Electrochemiluminescence (ECL) can measure normal and elevated levels of analytes within the same sample while delivering higher sensitivity than traditional ELISA.<span class=\"tooltip\"><sup id=\"3787\">3<\/sup><\/span><span class=\"tooltip\"><sup id=\"4095\">4<\/sup><\/span> It tolerates an array of complex biological matrices including serum, plasma, tissue culture media and accurately detects specific analyte levels in small sample volumes. Talk to us about custom multiplex panel design and validation.<\/p>\n","cta":""}],"media-option":"image","image":{"image":{"ID":7022,"id":7022,"title":"Lab_ali-tissue-culture-work-reoptimized","filename":"Lab_ali-tissue-culture-work-reoptimized.jpg","filesize":46167,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/lab_ali-tissue-culture-work-reoptimized\/","alt":"","author":"6","description":"","caption":"","name":"lab_ali-tissue-culture-work-reoptimized","status":"inherit","uploaded_to":5916,"date":"2024-02-22 20:23:47","modified":"2024-02-22 20:23:47","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":550,"height":405,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","medium-width":300,"medium-height":221,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","medium_large-width":550,"medium_large-height":405,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","large-width":550,"large-height":405,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","1536x1536-width":550,"1536x1536-height":405,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","2048x2048-width":550,"2048x2048-height":405,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized-540x398.jpg","small-width":540,"small-height":398,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized-540x405.jpg","square-sm-width":540,"square-sm-height":405,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","square-md-width":550,"square-md-height":405,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","portrait-width":550,"portrait-height":405,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Lab_ali-tissue-culture-work-reoptimized.jpg","landscape-width":550,"landscape-height":405}},"href":"","title":"","description":""},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e3c3648fee :arr="{"headline":"","content":"<h2>Simultaneous Multiparametric Analysis<\/h2>\n<p>Spectral flow cytometry enables high-throughput, comprehensive phenotypic and functional characterization of heterogenous cell populations using fluid dynamics. Full spectrum flow cytometry offers many advantages over traditional methods, including higher sensitivity for detection of low-expressed antigens, minimal need for compensation and up to 24 fluorophores for multiplexing.<span class=\"tooltip\"><sup id=\"3799\">1<\/sup><\/span><span class=\"tooltip\"><sup id=\"3800\">2<\/sup><\/span> Certis offers in-house flow cytometry expertise and custom panel design and validation.<\/p>\n","cta":{"title":"LEARN MORE","url":"https:\/\/www.certisoncology.com\/methods\/flow-cytometry-for-immuno-oncology\/","target":""},"media-option":"image","image":{"image":{"ID":6248,"id":6248,"title":"Image-6_Flow-cytometry-output-720x443-optimized","filename":"Image-6_Flow-cytometry-output-720x443-optimized.webp","filesize":194864,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized.webp","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/imaging-endpoint-analysis\/image-6_flow-cytometry-output-720x443-optimized\/","alt":"Image-6_Flow-cytometry-output","author":"6","description":"Image-6_Flow-cytometry-output","caption":"Image-6_Flow-cytometry-output","name":"image-6_flow-cytometry-output-720x443-optimized","status":"inherit","uploaded_to":5916,"date":"2024-01-30 23:08:23","modified":"2024-01-30 23:08:33","menu_order":0,"mime_type":"image\/webp","type":"image","subtype":"webp","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":720,"height":443,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized-150x150.webp","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized.webp","medium-width":300,"medium-height":185,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized.webp","medium_large-width":720,"medium_large-height":443,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized.webp","large-width":720,"large-height":443,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized.webp","1536x1536-width":720,"1536x1536-height":443,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized.webp","2048x2048-width":720,"2048x2048-height":443,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized-540x332.webp","small-width":540,"small-height":332,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized-540x443.webp","square-sm-width":540,"square-sm-height":443,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized.webp","square-md-width":720,"square-md-height":443,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized-640x443.webp","portrait-width":640,"portrait-height":443,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Image-6_Flow-cytometry-output-720x443-optimized.webp","landscape-width":720,"landscape-height":443}},"href":"","title":"The Power of Spectral Flow Cytometry ","description":"<p>Immune cells in human peripheral blood are identified by tSNE analysis using a 15 color panel. The Cytek\u2122 Aurora Spectral Cytometer (3 lasers, 38 detectors) has powerful analysis and data visualization capacity. Save time with comprehensive visualizations. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"right to left","vertical-align":"top"}}"></component-5f6e3c3648fee><component-5f7cbffb57673 :arr="{"content":[{"headline":"","entry":"<h2>Live Cell Imaging & Analysis<\/h2>\n<p>With IncuCyte<sup>\u00ae<\/sup> live cell imaging and analysis, Certis can capture cellular changes and data as they happen in real-time over hours, days, or weeks. This non-invasive <em>in vitro<\/em> technology facilitates investigation of many hallmarks of cancer, including:<\/p>\n<ol>\n<li><strong>Selective Proliferative Advantage:<\/strong> Interrogate cancer stem cell signaling pathways, and spatial distribution with cell growth and proliferation assays.<\/li>\n<li><strong>Altered Stress Response:<\/strong> Investigate excessive signaling, DNA damage, hypoxia and nutrient starvation with proliferation, cell health, and apoptosis assays.<\/li>\n<li><strong>Vascularization:<\/strong> Dissect cell proliferation, clustering, and differentiation<\/li>\n<li><strong>Invasion and Metastasis:<\/strong> Dissect sequential steps of metastasis with \u2018scratch wound\u2019 migration and invasion assays, chemotaxis assays, and growth and colonization studies.<\/li>\n<li><strong>Metabolic Rewiring:<\/strong> Characterize aberrant metabolic activity to gain insights into tumor progression, invasion, chemoresistance and identify new therapeutic targets.<\/li>\n<li><strong>Immune Modulation:<\/strong> Observe the dynamic interactions between immune and cancer cells with 3D immune cell-killing assays, antibody internalization, phagocytosis, and immunocytochemistry.<\/li>\n<li><strong>An Abetting Tumor Microenvironment:<\/strong> Gain insights into dynamic changes with co-culture invasion assays.<\/li>\n<\/ol>\n","cta":""}],"media-option":"video","image":{"image":false,"href":null,"title":"","description":""},"video-service":"vidyard","video":{"id":"NHWA3antVqMXHFwthpmXL8","title":"IncuCyte Live Cell Imaging Analysis Time-Lapse Video","description":"<p>Seen here is a Cytolight Green Lentivirus (LV) expression during puromycin selection in transduced glioblastoma cells from a PDX-derived cell culture (Model CRT00433 available in the <a href=\"https:\/\/www.certisoncology.com\/for-drug-developers\/cancer-models-preclinical-studies\/\">BarneyOI Cancer Model Database<sup>\u00ae<\/sup><\/a>, at an MOI of 3 for 12h, 24h, or 48h. Cytolight LV allows the non-perturbing labeling of target cells with homogenous expression of cytoplasmic GFP.<\/p>\n"},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e40ba1bdc4 :arr="{"title":" ","content":"","headline":"Preclinical Imaging and Endpoints: Answers to Frequently Asked Questions","items":[{"ID":3359,"post_author":"6","post_date":"2021-09-17 18:09:30","post_date_gmt":"2021-09-17 18:09:30","post_content":"<p>Certis will store your samples for a maximum of 30 days post-study completion, unless otherwise agreed upon (in the case of follow-on studies, analysis, or third-party availability.) Extended storage can be accommodated for an additional cost.<\/p>\n","post_title":"How long will Certis store my samples after the study ends?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-long-will-certis-store-my-samples-after-the-study-ends","to_ping":"","pinged":"","post_modified":"2021-09-17 22:10:16","post_modified_gmt":"2021-09-17 22:10:16","post_content_filtered":"","post_parent":3380,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3359","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3354,"post_author":"6","post_date":"2021-09-17 18:01:49","post_date_gmt":"2021-09-17 18:01:49","post_content":"<p>Yes, Certis can send your end of study samples to your collaborator directly. Simply provide your Certis study director with the shipping address, contact information and email address of the receiving party.<\/p>\n","post_title":"Will Certis send my end-of-study samples to my collaborator directly?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-certis-send-my-end-of-study-samples-to-my-collaborator-directly","to_ping":"","pinged":"","post_modified":"2024-02-16 19:26:16","post_modified_gmt":"2024-02-16 19:26:16","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3354","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3343,"post_author":"6","post_date":"2021-09-17 17:36:50","post_date_gmt":"2021-09-17 17:36:50","post_content":"<p>Yes, Certis can tag your cell lines, so that you can seamlessly go from <em>in vitro<\/em> tagging to <em>in vivo<\/em> validation. We have also tagged several of our own patient-derived cell lines with luciferase expression in-house. In addition, Certis has tagged client-supplied engineered cell lines harboring multiple resistance genes.<\/p>\n","post_title":"Will Certis tag my cell line for me?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-certis-tag-my-cell-line-for-me","to_ping":"","pinged":"","post_modified":"2024-02-16 19:27:14","post_modified_gmt":"2024-02-16 19:27:14","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3343","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3348,"post_author":"6","post_date":"2021-09-17 17:46:57","post_date_gmt":"2021-09-17 17:46:57","post_content":"<p>Yes, you can analyze protein expression in house at Certis. We offer multiple protein expression analysis assays, including immunohistochemistry, tumor tissue microarrays (TMA) that include 19-35 models per slide, ELISA, and Luminex<sup>\u00ae<\/sup> assays.<\/p>\n","post_title":"Will Certis perform protein expression analyses?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-i-analyze-protein-expression-in-house-at-certis","to_ping":"","pinged":"","post_modified":"2024-02-16 19:28:22","post_modified_gmt":"2024-02-16 19:28:22","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3348","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3355,"post_author":"6","post_date":"2021-09-17 18:02:26","post_date_gmt":"2021-09-17 18:02:26","post_content":"<p>Yes, Certis regularly sends study updates directly to our clients\u2019 secure online portals. Simply provide your Certis study director with access information at project kick-off.<\/p>\n","post_title":"Can Certis send study updates directly to my company\u2019s secure database?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-i-get-my-study-updates-sent-to-my-own-secure-database","to_ping":"","pinged":"","post_modified":"2024-02-16 19:29:21","post_modified_gmt":"2024-02-16 19:29:21","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3355","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3347,"post_author":"6","post_date":"2021-09-17 17:45:59","post_date_gmt":"2021-09-17 17:45:59","post_content":"<p>Yes, you can screen models in vitro before choosing an O-PDX model for your <em>in vivo<\/em> study. Certis offers a wide variety of <em>in vitro<\/em> screens depending on your study needs, including immunohistochemistry, IC50 dose response curve and spectral flow cytometry analysis.<\/p>\n<p>Alternatively, the <a href=\"https:\/\/www.certisoncology.com\/for-drug-developers\/predictive-oncology-intelligence\/\" target=\"_blank\" rel=\"noopener\">CertisAI\u2122 Predictive Oncology<\/a> platform is a pan-cancer solution that enables cancer researchers to effectively replace many discovery screening studies with <em>in silico<\/em> predictions and can predict which <em>in vitro<\/em> or <em>in vivo<\/em> models are most likely to respond to your compound or combination therapy.<\/p>\n","post_title":"Can I screen models in vitro before choosing a model for my in vivo study?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-i-screen-models-in-vitro-before-choosing-a-model-for-my-in-vivo-study","to_ping":"","pinged":"","post_modified":"2024-02-12 23:18:49","post_modified_gmt":"2024-02-12 23:18:49","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3347","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6274,"post_author":"6","post_date":"2024-01-30 23:56:20","post_date_gmt":"2024-01-30 23:56:20","post_content":"\n<p>Yes, Certis formulates mouse-scale drug doses in-house and can perform weekly or daily mouse-scale drug formulations as needed.<\/p>\n","post_title":"Does Certis formulate mouse-scale drug doses in-house?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"does-certis-formulate-mouse-scale-drug-doses-in-house-2","to_ping":"","pinged":"","post_modified":"2024-01-30 23:56:21","post_modified_gmt":"2024-01-30 23:56:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6274","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6275,"post_author":"6","post_date":"2024-01-30 23:58:27","post_date_gmt":"2024-01-30 23:58:27","post_content":"\n<p>Yes, we have a board-certified pathologist on staff for histology scoring. Our lab is Clinical Laboratory Improvement Amendments (CLIA) certified for high-complexity testing, which allows us to receive and process fresh tissue from patients and bypass long waiting periods that may often accompany outsourcing this type of screening. This reduces the turnaround time for pathologist scoring from several weeks to approximately one week. The Certis Oncology laboratory CLIA certification can be verified with our CLIA Number 05D2149049 on the <a href=\"https:\/\/qcor.cms.gov\/index_new.jsp\">CMS<\/a><a href=\"https:\/\/qcor.cms.gov\/index_new.jsp\" target=\"_blank\" rel=\"noreferrer noopener\"> website<\/a>. Select \u201cCLIA Laboratory Lookup\u201d under \u201cTool\u201d in the left-hand navigation.\u00a0<\/p>\n","post_title":"Will Certis perform histology scoring on-site?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"will-certis-perform-histology-scoring-on-site","to_ping":"","pinged":"","post_modified":"2024-02-27 23:58:45","post_modified_gmt":"2024-02-27 23:58:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6275","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3342,"post_author":"6","post_date":"2021-09-17 17:35:25","post_date_gmt":"2021-09-17 17:35:25","post_content":"<p>Yes, Certis has a limited collection of commercial cell lines in house and will procure any commercially available cell line of your choice. If you have a license to use a specific cell line, we will also accept samples sent directly to Certis and ensure that the license is upheld and protected by a Materials Transfer Agreement.<\/p>\n","post_title":"Does Certis have commercial cell lines?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"does-certis-have-commercial-cell-lines","to_ping":"","pinged":"","post_modified":"2021-09-17 21:01:48","post_modified_gmt":"2021-09-17 21:01:48","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3342","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3345,"post_author":"6","post_date":"2021-09-17 17:40:41","post_date_gmt":"2021-09-17 17:40:41","post_content":"<p>Yes, all histology is performed in-house at Certis, from common stains such as H&E to more complex, custom antibody staining.<\/p>\n<p>Unlike many general preclinical CROs, Certis has an in-house pathologist on staff to interpret histology slides and score them as needed. Digital images can be shared using free slide viewing software. Our staff pathologist is available for phone consultations regarding the histology results on a per-hour basis.<\/p>\n","post_title":"Does Certis perform histology in-house?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"does-certis-perform-histology-in-house","to_ping":"","pinged":"","post_modified":"2024-02-16 19:35:19","post_modified_gmt":"2024-02-16 19:35:19","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3345","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6276,"post_author":"6","post_date":"2024-01-31 00:00:31","post_date_gmt":"2024-01-31 00:00:31","post_content":"\n<p>No, Certis does not perform preclinical with syngeneic mouse models. While we understand syngeneic mouse models may have a place in cancer research, Certis focuses on human-derived tumors.<\/p>\n","post_title":"Does Certis perform preclinical studies with syngeneic mouse models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"does-certis-perform-preclinical-studies-with-syngeneic-mouse-models","to_ping":"","pinged":"","post_modified":"2024-01-31 00:00:32","post_modified_gmt":"2024-01-31 00:00:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6276","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6277,"post_author":"6","post_date":"2024-01-31 00:01:37","post_date_gmt":"2024-01-31 00:01:37","post_content":"\n<p>Yes, a standard Certis drug efficacy study runs for 28 days. However, we are happy to customize any study design. Let\u2019s talk about your ideas!<\/p>\n","post_title":"Can I customize how long my drug efficacy study is run?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"can-i-customize-how-long-my-drug-efficacy-study-is-run","to_ping":"","pinged":"","post_modified":"2024-01-31 00:01:38","post_modified_gmt":"2024-01-31 00:01:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6277","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3357,"post_author":"6","post_date":"2021-09-17 18:03:13","post_date_gmt":"2021-09-17 18:03:13","post_content":"<p>Yes, Certis provides a standard summary data report at the end of each study for no additional cost. We will also provide custom reporting from your templates for an additional fee.<\/p>\n","post_title":"Is a study report included in each study?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"is-a-study-report-included-in-each-study","to_ping":"","pinged":"","post_modified":"2024-02-16 19:36:51","post_modified_gmt":"2024-02-16 19:36:51","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3357","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3390,"post_author":"6","post_date":"2021-09-17 22:34:44","post_date_gmt":"2021-09-17 22:34:44","post_content":"<p>Spectral flow cytometry allows us to analyze the full fluorescence spectrum, which enables differentiation between fluorochromes that would normally be indistinguishable in traditional flow cytometry. While traditional flow cytometry generally requires some compensation to clearly differentiate between different populations, spectral flow cytometry requires almost no compensation, decreasing the risk of error and false positives and negatives.<sup>1<\/sup> <a href=\"https:\/\/www.certisoncology.com\/methods\/flow-cytometry-for-immuno-oncology\/\">Learn more<\/a> about spectral flow cytometry for characterization.<\/p>\n<figure class=\"wp-block-table is-style-regular\">\n<table>\n<tbody>\n<tr>\n<td> <\/td>\n<td><strong>Conventional Flow Cytometry<\/strong><\/td>\n<td><strong>Spectral Flow Cytometry with Certis<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Colors<\/strong><\/td>\n<td>Up to 18 colors<\/td>\n<td>Up to 24 colors<\/td>\n<\/tr>\n<tr>\n<td><strong>Detector per fluorochrome<\/strong><\/td>\n<td>1<\/td>\n<td>38<\/td>\n<\/tr>\n<tr>\n<td><strong>Spectrum analyzed<\/strong><\/td>\n<td>Narrow bandwidth analysis<\/td>\n<td>Entire spectral profile analysis<\/td>\n<\/tr>\n<tr>\n<td><strong>Able to distinguish overlapping fluorochromes<\/strong><\/td>\n<td>Difficult<\/td>\n<td>Accurate distinction<\/td>\n<\/tr>\n<tr>\n<td><strong>Compensation needed?<\/strong><\/td>\n<td>Yes<\/td>\n<td>No\/very little<\/td>\n<\/tr>\n<tr>\n<td><strong>Detector sensitivity<\/strong><\/td>\n<td>Standard<\/td>\n<td>Higher \u2013 able to evaluate expression of low-expressed antigens<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n\n\n<p><\/p>\n\n\n\n<p><strong>1<\/strong> Sanders CK, Mourant JR. <a href=\"https:\/\/www.certisoncology.com\/resources\/supporting-research\/#4023\" target=\"_blank\" rel=\"noreferrer noopener\">Advantages of Full Spectrum Flow Cytometry<\/a>. <em>J Biomed Opt<\/em>. 2013;18(3):037004.<\/p>\n","post_title":"What is the difference between spectral flow cytometry and traditional flow cytometry?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-is-the-difference-between-spectral-flow-cytometry-and-traditional-flow-cytometry","to_ping":"","pinged":"","post_modified":"2022-03-01 23:00:24","post_modified_gmt":"2022-03-01 23:00:24","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3390","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6279,"post_author":"6","post_date":"2024-01-31 00:02:56","post_date_gmt":"2024-01-31 00:02:56","post_content":"\n<p>Certis has a diverse suite of advanced preclinical imaging technologies, including mouse MRI imaging, bioluminescence imaging, Fluorescence, InCucyte<sup>\u00ae<\/sup> live cell imaging, and 3D tomographic imaging.<\/p>\n","post_title":"What types of preclinical imaging does Certis offer?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-types-of-preclinical-imaging-does-certis-offer","to_ping":"","pinged":"","post_modified":"2024-02-16 19:39:47","post_modified_gmt":"2024-02-16 19:39:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=6279","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3367,"post_author":"6","post_date":"2021-09-17 18:25:36","post_date_gmt":"2021-09-17 18:25:36","post_content":"<p><span class=\"TextRun SCXW139502280 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun CommentStart SCXW139502280 BCX0\">Certis can provide a variety of endpoints, including <\/span><\/span><span class=\"TextRun MacChromeBold SCXW139502280 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW139502280 BCX0\">tumor volume <\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">calculation<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">s<\/span><\/span><span class=\"TextRun SCXW139502280 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW139502280 BCX0\"> over time <\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">compare<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\"> to control group<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">, growth curves, <\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">PK\/PD sampling and analysis, biomarker identification, immune cell characterization by flow cytometry, toxicity, ADME<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">, <\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">o<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">verall survival<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">,<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\"> and disease-free survival (Kaplan Meier Curves), necropsy analysis of metastasis, <\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">cell population characterization, phenotypic analysis, histological analysis and enzyme-linked immunoassay (ELISA).<\/span> <span class=\"NormalTextRun SCXW139502280 BCX0\">Common <\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">pharmacological <\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">endpoint analysis includes Homogeneous Time-Resolved Fluorescence (HTRF), <\/span><\/span><span class=\"TextRun MacChromeBold SCXW139502280 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW139502280 BCX0\">Meso<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\"> Scale Discovery<\/span><\/span><span class=\"TextRun SCXW139502280 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW139502280 BCX0\"> (MSD<sup>\u00ae<\/sup>), <\/span><\/span><span class=\"TextRun MacChromeBold SCXW139502280 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW139502280 BCX0\">spectral flow cytometry<\/span><\/span><span class=\"TextRun SCXW139502280 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW139502280 BCX0\"> for analyzing cell subpopulations in blood (on study) and\/or post-takedown in other tissues<\/span><span class=\"NormalTextRun SCXW139502280 BCX0\">.\u00a0<\/span><\/span><span class=\"EOP SCXW139502280 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n","post_title":"What types of endpoints are available for my study?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-types-of-endpoints-are-available-for-my-study","to_ping":"","pinged":"","post_modified":"2024-02-16 19:41:31","post_modified_gmt":"2024-02-16 19:41:31","post_content_filtered":"","post_parent":3383,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3367","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"}],"cta":"","layout":{"background":"","background-offset":""}}"></component-5f6e40ba1bdc4><component-5f7e3c2a849f9 :arr="{"title":"Talk to Us About Driving Reproducible Results for Your Drug Candidates Today","description":"<h3 id=\"Enter-your-information\">Enter your information<a href=\"#Enter-your-information\"><\/a><\/h3>\n","id":"d2c7e296-8077-48de-9a07-bef5ead14e2d","options":{"active":""}}"></component-5f7e3c2a849f9><component-5f6e424bba9c9 :arr="{"headline":"How Can We Help?","description":"","cta":{"title":"Contact Us","url":"https:\/\/www.certisoncology.com\/contact-us\/","target":""},"layout":{"background":"cells","style":"default","sticky":true}}"></component-5f6e424bba9c9> </div> <footer> <div class="container"> 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