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[{"id":48590408,"identifier":"Attachment_48590408","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":7128997,"created_at":"2014-05-22T13:27:46.897-07:00","from_world_paper_id":124645300,"updated_at":"2024-11-11T22:15:58.321-08:00","_data":{"grobid_abstract":"The dynamic properties of the cerebral metabolic rate of oxygen consumption (CMR O2 ) during changes in brain activity remain unclear. Therefore, the spatial and temporal evolution of functional increases in CMR O2 was investigated in the rat somato-sensory cortex during forelimb stimulation under a suppressed blood flow response condition. Temporally, stimulation elicited a fast increase in tissue mitochondria CMR O2 described by a time constant of B1 second measured using flavoprotein autofluorescence imaging. CMR O2 -driven changes in the tissue oxygen tension measured using an oxygen electrode and blood oxygenation measured using optical imaging of intrinsic signal followed; however, these changes were slow with time constants of B5 and B10 seconds, respectively. This slow change in CMR O2 -driven blood oxygenation partly explains the commonly observed post-stimulus blood oxygen level-dependent (BOLD) undershoot. Spatially, the changes in mitochondria CMR O2 were similar to the changes in blood oxygenation. Finally, the increases in CMR O2 were well correlated with the evoked multi-unit spiking activity. These findings show that dynamic CMR O2 calculations made using only blood oxygenation data (e.g., BOLD functional magnetic resonance imaging (fMRI)) do not directly reflect the temporal changes in the tissue's mitochondria metabolic rate; however, the findings presented can bridge the gap between the changes in cellular oxidative rate and blood oxygenation.","publication_date":"2012,,","publication_name":"Journal of Cerebral Blood Flow and Metabolism","grobid_abstract_attachment_id":"48590408"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Evolution of the dynamic changes in functional cerebral oxidative metabolism from tissue mitochondria to blood oxygen","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [12283310]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; 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ds2-5-body-xs">Journal of Neurochemistry, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cerebral oxygen demand for short-lived and steady-state events","attachmentId":73336336,"attachmentType":"pdf","work_url":"https://www.academia.edu/59387105/Cerebral_oxygen_demand_for_short_lived_and_steady_state_events","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/59387105/Cerebral_oxygen_demand_for_short_lived_and_steady_state_events"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="13437061" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13437061/Frequency_Dependent_Changes_in_Cerebral_Metabolic_Rate_of_Oxygen_During_Activation_of_Human_Visual_Cortex">Frequency-Dependent Changes in Cerebral Metabolic Rate of Oxygen During Activation of Human Visual Cortex</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32659461" href="https://ku-dk.academia.edu/MVafaee">M. Vafaee</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Cerebral Blood Flow & Metabolism, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Frequency-Dependent Changes in Cerebral Metabolic Rate of Oxygen During Activation of Human Visual Cortex","attachmentId":45342704,"attachmentType":"pdf","work_url":"https://www.academia.edu/13437061/Frequency_Dependent_Changes_in_Cerebral_Metabolic_Rate_of_Oxygen_During_Activation_of_Human_Visual_Cortex","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13437061/Frequency_Dependent_Changes_in_Cerebral_Metabolic_Rate_of_Oxygen_During_Activation_of_Human_Visual_Cortex"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="11925826" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/11925826/Spectroscopic_analysis_of_neural_activity_in_brain_increased_oxygen_consumption_following_">Spectroscopic analysis of neural activity in brain: increased oxygen consumption following …</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29530872" href="https://independent.academia.edu/CoffeyPeter">Peter Coffey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neuroimage, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Spectroscopic analysis of neural activity in brain: increased oxygen consumption following …","attachmentId":46434133,"attachmentType":"pdf","work_url":"https://www.academia.edu/11925826/Spectroscopic_analysis_of_neural_activity_in_brain_increased_oxygen_consumption_following_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/11925826/Spectroscopic_analysis_of_neural_activity_in_brain_increased_oxygen_consumption_following_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="19361905" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19361905/Trial_by_trial_relationship_between_neural_activity_oxygen_consumption_and_blood_flow_responses">Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39627693" href="https://pitt.academia.edu/AlbertoVazquez">Alberto Vazquez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">NeuroImage, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">Trial-by-trial variability in local field potential (LFP), tissue partial pressure of oxygen (PO2), cerebral blood flow (CBF), and deoxyhemoglobin-weighted optical imaging of intrinsic signals (OIS) were tested in the rat somatosensory cortex while fixed electrical forepaw stimulation (1.0-ms pulses with amplitude of 1.2 mA at a frequency of 6 Hz) was repeatedly applied. The changes in the cerebral metabolic rate of oxygen (CMRO2) were also evaluated using a hypotension condition established by our group based on the administration of a vasodilator. Under normal conditions, CBF, PO2, and OIS showed positive signal changes (48%, 32%, and 0.42%, respectively) following stimulation. Over multiple trials, the CBF responses were well correlated with the integral of the LFP amplitudes (sigmaLFP) (Rmean=0.78), whereas a lower correlation was found between PO2 and sigmaLFP (Rmean=0.60) and between OIS and sigmaLFP (Rmean=0.54). Under the hypotension condition the LFP responses were preserved, but the CBF responses were suppressed and the PO2 and OIS changes were negative (-12% and -0.28%, respectively). In this condition, the trial-by-trial variations in PO2 and OIS were well correlated with the variability in sigmaLFPs (Rmean= -0.77 and -0.76, respectively), indicating a single trial coupling between CMRO2 changes and sigmaLFP. These findings show that CBF and CMRO2 signals are more directly correlated with neural activity compared to blood oxygen-sensitive methods such as OIS and BOLD fMRI.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses","attachmentId":42096008,"attachmentType":"pdf","work_url":"https://www.academia.edu/19361905/Trial_by_trial_relationship_between_neural_activity_oxygen_consumption_and_blood_flow_responses","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/19361905/Trial_by_trial_relationship_between_neural_activity_oxygen_consumption_and_blood_flow_responses"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":48590408,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":48590408,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_48590408" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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LaManna</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Research, 1981</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Local tissue oxygen tension - cytochrome a,a3 redox relationships in rat cerebral cortex in vivo","attachmentId":68232438,"attachmentType":"pdf","work_url":"https://www.academia.edu/50132211/Local_tissue_oxygen_tension_cytochrome_a_a3_redox_relationships_in_rat_cerebral_cortex_in_vivo","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/50132211/Local_tissue_oxygen_tension_cytochrome_a_a3_redox_relationships_in_rat_cerebral_cortex_in_vivo"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="30876863" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30876863/_Spectroscopic_Analysis_of_Neural_Activity_in_Brain_Increased_Oxygen_Consumption_Following_Activation_of_Barrel_Cortex_">“Spectroscopic Analysis of Neural Activity in Brain: Increased Oxygen Consumption Following Activation of Barrel Cortex”</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58771282" href="https://independent.academia.edu/MylesJones1">Myles Jones</a></div><p class="ds-related-work--metadata ds2-5-body-xs">NeuroImage, 2001</p><div 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class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="30876870" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30876870/Increased_Oxygen_Consumption_Following_Activation_of_Brain_Theoretical_Footnotes_Using_Spectroscopic_Data_from_Barrel_Cortex">Increased Oxygen Consumption Following Activation of Brain: Theoretical Footnotes Using Spectroscopic Data from Barrel Cortex</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58771282" href="https://independent.academia.edu/MylesJones1">Myles Jones</a></div><p class="ds-related-work--metadata ds2-5-body-xs">NeuroImage, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Increased Oxygen Consumption Following Activation of Brain: Theoretical Footnotes Using Spectroscopic Data from Barrel Cortex","attachmentId":51302949,"attachmentType":"pdf","work_url":"https://www.academia.edu/30876870/Increased_Oxygen_Consumption_Following_Activation_of_Brain_Theoretical_Footnotes_Using_Spectroscopic_Data_from_Barrel_Cortex","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/30876870/Increased_Oxygen_Consumption_Following_Activation_of_Brain_Theoretical_Footnotes_Using_Spectroscopic_Data_from_Barrel_Cortex"><span 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