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{"work":{"id":14784182,"created_at":"2015-08-09T06:01:24.102-07:00","from_world_paper_id":140670096,"updated_at":"2024-11-14T03:18:57.306-08:00","_data":{"grobid_abstract":"Changes in cerebral blood oxygenation due to functional activation of the primary sensorimotor cortex during a unilateral finger opposition task were simultaneously mapped by deoxyhemoglobin-sensitive magnetic resonance imaging (MRI) and monitored by near-infrared spectroscopy (NIRS). Activation foci along the contralateral central sulcus displayed task-associated increases in MRI signal intensity, indicating a concomitant decrease of the focal concentration of deoxyhemoglobin. This interpretation was confirmed by simultaneous reductions in deoxyhemoglobin measured optically. Since observation of the latter effect required exact spatial matching of the MRI-detected activation foci and position of the fiber optic bundles (\"optodes\") used for transmitting and receiving light, it may be concluded that optical recordings of changes in deoxyhemoglobin during functional challenge probe only a restricted brain tissue region. While deoxyhemoglobin responses seen by NIRS were smaller for ipsithan for contralateral finger movements, task-related increases in oxyhemoglobin were rather similar between both conditions and, thus, seem to be less specific. Furthermore, no consistent changes were obtained for total hemoglobin during task performance, possibly due to the short timing of the repetitive protocol. In general, results underline, in humans, the hitherto assumed signal physiology for functional brain mapping by oxygenationsensitive MRI and allow assessment of both constraints and practicability of functional studies by NIRS.","publication_date":"1996,,","publication_name":"Journal of Cerebral Blood Flow \u0026 Metabolism","grobid_abstract_attachment_id":"43898181"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Simultaneous Recording of Cerebral Blood Oxygenation Changes During Human Brain Activation by Magnetic Resonance Imaging and Near-Infrared Spectroscopy","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [33841790,33748550]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; 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near-infrared optical imaging","attachmentId":32148760,"attachmentType":"pdf","work_url":"https://www.academia.edu/4874102/Hemodynamic_evoked_response_of_the_sensorimotor_cortex_measured_noninvasively_with_near_infrared_optical_imaging","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4874102/Hemodynamic_evoked_response_of_the_sensorimotor_cortex_measured_noninvasively_with_near_infrared_optical_imaging"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="2874375" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2874375/Diffuse_optical_measurement_of_blood_flow_blood_oxygenation_and_metabolism_in_a_human_brain_during_sensorimotor_cortex_activation">Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="1835753" href="https://icfo.academia.edu/TurgutDurduran">Turgut Durduran</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2004</p><p class="ds-related-work--abstract ds2-5-body-sm">We combine diffuse optical and correlation spectroscopies to simultaneously measure the oxyhemoglobin and deoxyhemoglobin concentration and blood flow in an adult human brain during sensorimotor stimulation. The observations permit calculation of the relative cerebral metabolic rate of oxygen in the human brain, for the first time to our knowledge, by use of all-optical methods.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation","attachmentId":30811297,"attachmentType":"pdf","work_url":"https://www.academia.edu/2874375/Diffuse_optical_measurement_of_blood_flow_blood_oxygenation_and_metabolism_in_a_human_brain_during_sensorimotor_cortex_activation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2874375/Diffuse_optical_measurement_of_blood_flow_blood_oxygenation_and_metabolism_in_a_human_brain_during_sensorimotor_cortex_activation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="6498599" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/6498599/Temporal_decoupling_of_oxy_and_deoxy_hemoglobin_hemodynamic_responses_detected_by_functional_near_infrared_spectroscopy_fNIRS_">Temporal decoupling of oxy- and deoxy-hemoglobin hemodynamic responses detected by functional near-infrared spectroscopy (fNIRS)</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="1023063" href="https://unt.academia.edu/nicoladie">Nicoladie Tam</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biomedical Engineering and Medical Imaging, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">This study provides experimental evidence that there is temporal decoupling between the hemodynamic responses of oxy- and deoxy-hemoglobin (Hb) as detected by functional near-infrared spectroscopy (fNIRS). Using 64 spatially distributed optrodes to record motor cortical activities during a free arm movement task (right-left and front-back movements), we detected that the temporal profile of oxy- and deoxy-Hb responses are desynchronized and decoupled (i.e., oxy- and deoxy-Hb levels do not rise and fall at the same time). We correlated four different measures of hemodynamic profiles with the arm movements, namely, oxy- (HbO2) and deoxy-hemoglobin (Hb) and their summation (HbO2 + Hb) and difference (HbO2 - Hb) signals. These measures correspond to the changes in oxygen delivery, oxygen extraction, total blood volume delivered, and total oxygenation with specific movement directions, respectively. They revealed different components of the hemodynamic response in a localized neuronal population in the motor cortex. The results suggested that, by using these four measures, oxygen delivery and oxygen extraction can be coupled in one movement direction, but decoupled in another movement direction for the same human subject executing the same movement task. Oxygen delivery and oxygen extraction do not always co-vary together temporally. Thus, using a single measure of oxygen delivery or extraction alone may not be sufficient to determine whether the cortical area is activated or deactivated. Rather, a combination of all four measures of hemodynamic signals that represent temporal coupling and decoupling of oxygen delivery and extraction is needed to differentiate the temporal profiles of neural activation and deactivation. It demonstrated that different hemodynamic measures can reveal temporally decoupled activation/deactivation patterns differentially during the right-left and front-back motor task. Therefore, relying on a single measure of deoxy-Hb may be insufficient to characterize the neural responses without the oxy-Hb measure. Orthogonal arm movement (right-left vs. front-back) directions can be differentiated based on the differential temporally coupled and decoupled hemodynamics.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Temporal decoupling of oxy- and deoxy-hemoglobin hemodynamic responses detected by functional near-infrared spectroscopy (fNIRS)","attachmentId":34025668,"attachmentType":"pdf","work_url":"https://www.academia.edu/6498599/Temporal_decoupling_of_oxy_and_deoxy_hemoglobin_hemodynamic_responses_detected_by_functional_near_infrared_spectroscopy_fNIRS_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/6498599/Temporal_decoupling_of_oxy_and_deoxy_hemoglobin_hemodynamic_responses_detected_by_functional_near_infrared_spectroscopy_fNIRS_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="86717516" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/86717516/Intersubject_variability_of_near_infrared_spectroscopy_signals_during_sensorimotor_cortex_activation">Intersubject variability of near-infrared spectroscopy signals during sensorimotor cortex activation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4972825" href="https://independent.academia.edu/YutakaFuchino">Yutaka Fuchino</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biomedical Optics, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intersubject variability of near-infrared spectroscopy signals during sensorimotor cortex activation","attachmentId":91106556,"attachmentType":"pdf","work_url":"https://www.academia.edu/86717516/Intersubject_variability_of_near_infrared_spectroscopy_signals_during_sensorimotor_cortex_activation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/86717516/Intersubject_variability_of_near_infrared_spectroscopy_signals_during_sensorimotor_cortex_activation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":43898181,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":43898181,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_43898181" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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