Rheumatoid Arthritis Treatment | ENBREL® (etanercept)

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See Full Prescribing & Safety Info." property="og:description" /><meta content="website" property="og:type" /><meta content="https://www.enbrel.com/-/media/Themes/Amgen/Enbrel-com-Redesign/Enbrel-com-Redesign/Images/Logos/enbrel-logo.png" property="og:image" /><meta content="Rheumatoid Arthritis Treatment | ENBREL® (etanercept)" property="og:title" /><meta content="https://www.enbrel.com/rheumatoid-arthritis" property="og:url" /> <meta content="Learn about ENBREL® (etanercept) for moderate to severe rheumatoid arthritis (RA). See Full Prescribing & Safety Info." name="description" /> <meta content="rheumatoid-arthritis" name="twitter:title" /><meta content="summary_large_image" name="twitter:card" /> <meta name="viewport" content="width=device-width, initial-scale=1"/> <link rel="alternate" hreflang="en" href="http://www.enbrel.com/rheumatoid-arthritis" /> <meta content="https://www.enbrel.com/rheumatoid-arthritis" name="twitter:url" /> <link rel="canonical" href="https://www.enbrel.com/rheumatoid-arthritis"> <script>dataLayer = [{'pageType':'rheumatoid arthritis','siteSection':'rheumatoid arthritis','contentType':'patient','condition':'ra'}];</script>  <script> (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window, document, 'script', 'dataLayer', 'GTM-KRDMH8'); </script>  </head> <body class="rheumatoid-arthritis video-container icon-animation default-device bodyclass">  <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-KRDMH8" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript>  <div id="fb-root"></div> <div id="wrapper"> </div> <header class="header-nav"> <div class="quantum-container--light quantum-indications " id=""> <div class="quantum-indications__inner"> <h6 class="quantum-indications__title">Indications</h6> <p class="quantum-indications__copy quantum-text quantum-text--small"> <span class="medium">ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.</span> <span class="readmore"><a href="javascript:void(0);" class="quantum-link quantum-indications__read-more-link seeMore">Read more</a></span> </p> <div class="quantum-indications__copy quantum-indications__copy--read-more quantum-long-form-text" style="display: none;"> <p> <span class="medium">ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.</span> </p> <p> <span class="medium">ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years of age or older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).</span> </p> <p> <span class="medium">ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in adult patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.</span> </p> <p> <span class="medium">ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.</span> </p> <p> <span class="medium">ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (pJIA) in children 2 years of age or older.</span> </p> <p class="mb-0"> <span class="medium">ENBREL is indicated for active juvenile psoriatic arthritis (JPsA) in children 2 years of age or older.</span> </p> <p class="indiction-close"><a href="javascript:void(0);" class="quantum-link quantum-indications__read-less-link seeLess">close</a></p> </div> <button class="quantum-button quantum-button--tertiary quantum-indications__close quantum-button--icon-only" id="indicationClose" type="button"> <svg class="quantum-icon quantum-button__icon"> <use 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src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Logos/enbrel-header-logo.svg?la=en&hash=AD3C2CAA18169CCEF4C4A0CB955E7BA5" class="quantum-header__logo" rel="preload" fetchpriority="high" alt="ENBREL® header logo" /> </a> <a class="quantum-header__logo d-block d-sm-none gtm-header" href="/" > <img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Logos/enbrel-header-logo.svg?la=en&hash=AD3C2CAA18169CCEF4C4A0CB955E7BA5" class="quantum-header__logo" rel="preload" fetchpriority="high" alt="ENBREL® header logo" /> </a> </div> <div class="col-8 col-sm-8 col-md-8 col-lg-8 col-xl-8 p0"> <div class="quantum-header " id=""> <div class="quantum-header__inner"> <div class="quantum-header__left "> </div> <div class="quantum-header__right "> <div class="quantum-header__menu"> <nav class="quantum-drop-down-menu"> <ul class="quantum-drop-down-menu__list"> <li class="quantum-drop-down-menu__list-item submenu-dropdown condition-dropdown"> <a href="/rheumatoid-arthritis" class=" quantum-drop-down-menu__link navigate gtm-header gtm-navigation-click" ca1="" data-value="FLItem-1" > <span class="quantum-drop-down-menu__link-text"> Choose your Condition </span> <svg class="quantum-icon quantum-button__icon desktop-break"> <use xlink:href="-/media/Themes/Global/Global/Global/images/amgen.svg#angle-down-regular"></use> </svg> <svg class="quantum-icon quantum-drop-down-menu__link-icon quantum-drop-down-menu__link-icon--expand-dropdown"> <use xlink:href="-/media/Themes/Global/Global/Global/images/amgen.svg#plus-circle-regular"></use> </svg> <svg class="quantum-icon quantum-drop-down-menu__link-icon quantum-drop-down-menu__link-icon--collapse-dropdown"> <use xlink:href="-/media/Themes/Global/Global/Global/images/amgen.svg#minus-circle-regular"></use> </svg> </a> <ul class="quantum-drop-down-menu__menu"> <li class="quantum-drop-down-menu__menu-list-item"> <a href="/rheumatoid-arthritis" class="quantum-drop-down-menu__menu-link " data-value="FLItem-1-SLItem-1"> Rheumatoid Arthritis </a> </li> <li class="quantum-drop-down-menu__menu-list-item"> <a href="/psoriatic-arthritis" class="quantum-drop-down-menu__menu-link navigate gtm-header gtm-navigation-click " data-value="FLItem-1-SLItem-2"> Adult Psoriatic Arthritis </a> </li> <li class="quantum-drop-down-menu__menu-list-item"> <a href="/ankylosing-spondylitis" class="quantum-drop-down-menu__menu-link " data-value="FLItem-1-SLItem-3"> Ankylosing Spondylitis </a> </li> <li class="quantum-drop-down-menu__menu-list-item"> <a href="/juvenile-idiopathic-arthritis" class="quantum-drop-down-menu__menu-link " data-value="FLItem-1-SLItem-4"> Juvenile Idiopathic Arthritis </a> </li> <li class="quantum-drop-down-menu__menu-list-item"> <a href="/plaque-psoriasis" class="quantum-drop-down-menu__menu-link navigate gtm-header gtm-navigation-click " data-value="FLItem-1-SLItem-5"> Plaque Psoriasis </a> </li> </ul> </li> </ul> <ul class="quantum-drop-down-menu__top-nav-list "> </ul> </nav> </div> <div class="quantum-header__mobile-content "> <button class="quantum-button quantum-button--tertiary quantum-header__icon-button quantum-button--large quantum-button--icon-only " type="button"> <svg class="quantum-icon quantum-button__icon"> <use xlink:href="-/media/Themes/Global/Global/Global/images/amgen.svg#search-regular"></use> </svg> </button> <button class="quantum-button quantum-button--tertiary quantum-header__icon-button quantum-header__menu-trigger quantum-header__menu-trigger--expand-menu quantum-button--large quantum-button--icon-only" type="button"> <svg class="quantum-icon quantum-button__icon"> <use xlink:href="-/media/Themes/Global/Global/Global/images/amgen.svg#bars-regular"></use> </svg> </button> <button class="quantum-button quantum-button--tertiary quantum-header__icon-button quantum-header__menu-trigger quantum-header__menu-trigger--collapse-menu quantum-button--large quantum-button--icon-only" type="button"> <svg class="quantum-icon quantum-button__icon"> <use xlink:href="-/media/Themes/Global/Global/Global/images/amgen.svg#close-light"></use> </svg> </button> </div> </div> </div> </div> </div> </div> </div> </div><div class="component plain-html what-is desktop-only max-width"> <div class="component-content"> <p><b>What is moderate to severe rheumatoid arthritis (RA)?</b></p> <p>With RA, your immune system creates too much of a protein called tumor necrosis factor (TNF). Too much TNF may lead to inflammation that causes the pain, swelling, and damage of your joints over time. Symptoms may include joint pain, swelling, stiffness, and tiredness.</p> </div> </div> <div class="component container full-width jumplink max-width"> <div class="component-content" > <div class="component link-list"> <div class="component-content"> <ul> <li class="item0 odd first"> <div class="field-link"><a href="#why-enbrel" data-variantitemid="{D25D5AAC-412E-44FE-AA1E-7FBF6507F374}" data-variantfieldname="Link">WHY ENBREL?</a></div> </li> <li class="item1 even"> <div class="field-link"><a href="#side-effects" data-variantitemid="{413CF4C4-1488-428F-B4AE-ED01B47134E0}" data-variantfieldname="Link">SIDE EFFECTS</a></div> </li> <li class="item2 odd last"> <div class="field-link"><a href="#talk-to-your-doctor" data-variantitemid="{3C7248A7-B27E-4F88-8C17-7E5F49EF42ED}" data-variantfieldname="Link">TALKING TO YOUR DOCTOR</a></div> </li> </ul> </div> </div> </div> </div><div class="component plain-html what-is max-width mobile-only"> <div class="component-content"> <p><b>What is moderate to severe rheumatoid arthritis (RA)?</b></p> <p>With RA, your immune system creates too much of a protein called tumor necrosis factor (TNF). Too much TNF may lead to inflammation that causes the pain, swelling, and damage of your joints over time. Symptoms may include joint pain, swelling, stiffness, and tiredness.</p> </div> </div> <div class="component container page-banner" id="why-enbrel"> <div class="component-content" > <div class="quantum-hero quantum-hero--image-position- quantum-container-- quantum-hero--multiple-background-images " id=""> <div class="quantum-hero__inner" style="background-image:url(-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/Banner/ra-hero-img.jpg),url(-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/Banner/ra-hero-img.jpg)"> </div> <div class="quantum-hero__text"> <div class="quantum-hero__text-inner quantum-long-form-text"> <h5>WHY ENBREL? <h3 class="mobileOnly why-mob">How can ENBREL help you with moderate to severe rheumatoid arthritis?</h3></h5> <h2> </h2> </div> </div> </div> </div> </div> <div class="component container how-can"> <div class="component-content" > <div class="component plain-html col-12 desktopOnly max-width"> <div class="component-content"> <h3 class="desktopOnly">How can ENBREL help you with moderate to severe rheumatoid arthritis?</h3> </div> </div> <div class="row component column-splitter"> <div class="col-12 col-sm-12 col-md-6 col-lg-6 col-xl-6 contain lft-card"> <div class="component promo bgChange"> <div class="component-content"> <div class="side-effect-1 enbrel-flex mb-20 mb20_mob"><div class="mobile-hide field-promoicon"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Common/how1.png?h=126&iar=0&w=130&hash=F2E52B030E07477207FD0CA617BCB44E" class="lozad" alt="Joint pain icon" width="130" height="126" data-variantfieldname="PromoIcon" data-src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Common/how1.png" data-variantitemid="{AFCDBC33-BC70-41D0-8FE4-9DBDA9EC91DE}" /></div><div class="mob-width field-promotext2"><div class="en-helps"> <p class="mb0 ft-20">ENBREL helps</p> <h4 class="ft-24">significantly <br class="desktop-only">relieve joint pain </h4> </div></div></div><div class="side-effect-2 enbrel-flex mb-20 mb20_mob"><div class="mobile-hide field-promoicon2"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Common/how2.png?h=118&iar=0&w=132&hash=09DDE8A674F5E4D151ECE1C12770C253" class="lozad" alt="Joint damage icon" width="132" height="118" data-variantfieldname="PromoIcon2" data-src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Common/how2.png" data-variantitemid="{AFCDBC33-BC70-41D0-8FE4-9DBDA9EC91DE}" /></div><div class="mob-width field-promotext3"><div class="en-helps2"> <p class="mb0 ft-20">and helps</p> <h4 class="ft-24">stop permanent <br class="desktop-only">joint damage</h4> <p class="mb0 ft-20">caused by moderate to severe RA.</p> </div> </div></div> </div> </div> <div class="component plain-html" id="enbrel-biological-treatment-mobile"> <div class="component-content"> <p>ENBREL is a type of treatment known as a biologic—which means it’s made from living cells. ENBREL is designed to attach to TNF proteins to help block their activity and help relieve symptoms of moderate to severe RA. Treating moderate to severe RA with ENBREL can help you get back to many of the activities that you enjoy.</p> <p>Try out our <a href="#joint-damage-simulator">Joint Damage Simulator</a> to see how joint damage can progress.</p> </div> </div> </div> <div class="col-12 col-sm-12 col-md-6 col-lg-6 col-xl-6 contain accordion-video p0"> <div> <div class="row mx-0 text-video-container " id=""> <div class="col-12 col-md-6 px-0 p-y-40"> <div class="txt-section "> </div> </div> <div class="col-12 col-md-6 px-0 p-y-40 m-auto"> <div id="videoteaserid" style="position:relative;min-height:100%;max-height:unset" class="video-thumb" data-url-video-id=animatedinjection> <video data-video-id="6360650086112" data-account="3785504782001" data-player="rxCXn2kmfS" data-embed="default" data-application-id class="video-js img-section" controls id="videoplayer-mobile-6360650086112" style="height:inherit"></video> <div class="vd-teasercl"> </div> <script src=//players.brightcove.net/3785504782001/rxCXn2kmfS_default/index.min.js> </script> </div> </div> </div> </div> </div> </div> <div class="component link full-width max-width"> <div class="component-content"> <div class="field-link"><a href="/-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Documents/MOA-transcript.pdf" rel="noopener noreferrer" data-variantitemid="{653A5486-AD8D-43FD-BD95-E5560C4BA59C}" data-variantfieldname="Link" class="green-color-text" target="_blank">Read Video Transcript</a></div> </div> </div><div class="component plain-html" id="try-out-joint-damage-mobile"> <div class="component-content"> <p>Try out our Joint Damage Simulator to see how joint damage can progress</p> </div> </div><div class="component plain-html full-width how-can-sec max-width"> <div class="component-content"> <p>ENBREL is a type of treatment known as a biologic—which means it’s made from living cells. ENBREL is designed to attach to TNF proteins to help block their activity and help relieve symptoms of moderate to severe RA. Treating moderate to severe RA with ENBREL can help you get back to many of the activities that you enjoy.</p> <p>Try out our <a href="#joint-damage-simulator">Joint Damage Simulator</a> to see how joint damage can progress.</p> </div> </div> </div> </div> <div class="component container full-width how-long"> <div class="component-content" > <div class="component rich-text"> <div class="component-content"> <div class="max-width"> <div class="component-content"> <h3 id="animHeading">How long does it take for ENBREL to work for rheumatoid arthritis?</h3> <p>ENBREL works differently with each person. Some results are seen quickly, and other times it may take a little longer. Taking ENBREL as prescribed by your doctor will help ENBREL give you the best chance of working for you. <b> Your results may vary.</b></p> </div> </div> <div class="bg-light-blue"> <p class="blue-color medical-study"><b>In a medical study:</b></p> <div class="ra-medical-study mobileOnly"> <div class="weeks-mob medical-study-mobile"> <img class="img_aminMob" src="/-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/rheumatoid-arthritis/ra-medical-study-mobile.svg" alt="Timeline of how long it takes ENBREL® to work for rheumatoid arthritis"> </div> </div> <div class="weeks-mob medical-study-desktop desktopOnly"> <img class="img_animDT" src="/-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/rheumatoid-arthritis/ra-medical-study-desktop.svg" alt="Timeline of how long it takes ENBREL® to work for rheumatoid arthritis"> </div> </div> <div class="max-width"> <div class="component-content"> <p>Keep taking ENBREL as prescribed by your doctor to see how ENBREL might work for you. Keep in mind your results may vary. You may need to give ENBREL time to work. Most people finding relief saw results within 3 months, and some saw further improvements at 6 months.</p> <p>Be sure to work with your doctor throughout your treatment with ENBREL.</p> </div> </div> </div> </div> </div> </div> <div class="component container full-width joint-sim" id="joint-damage-simulator"> <div class="component-content" > <div class="row component column-splitter"> <div class="col-6"> <div class="component plain-html col-12"> <div class="component-content"> <div class="damage-simulator"> <p class="rapa">Rheumatoid Arthritis & Psoriatic Arthritis</p> <h3>Joint Damage Simulator</h3> <p class="mera">Moderate to severe RA can lead to irreversible <span class="white-bold">joint damage</span>.</p> <p><span class="white-bold">What does permanent joint damage</span> look like? Use this Joint Damage Simulator to see how joint damage can get worse over time.</p> </div> </div> </div> </div> <div class="col-6"> <div class="quantum-hero quantum-hero--image-position- quantum-container-- quantum-hero--multiple-background-images " id=""> <div class="quantum-hero__inner" style="background-image:url(-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Common/hand.png),url(-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Common/Joint-Damage-Simulator-mobile.png)"> </div> <div class="quantum-hero__text"> <div class="quantum-hero__text-inner quantum-long-form-text"> <h5><section class="application"> <div class="container"> <div class="text-holder-content d-none"> <p>Whether you have moderate to severe rheumatoid arthritis (RA) or psoriatic arthritis (PsA), joint pain, stiffness, and swelling are common reminders of your condition. They can also be a sign of something else: permanent joint damage that cannot be undone.</p> <p>Use the Joint Damage Simulator to see how permanent joint damage can progress if not treated with the right kinds of medication.</p> </div> <div class="js-simulator"> <div class="js-simulator-start"> <div class="visible-on-start text-center"> <div class="logo-holder d-flex align-items-center justify-content-center"> </div> <h1>Watch how joint damage may progress over time.*</h1> </div> <div class="welcome-hand"></div> <div class="control-group"> <div class="ra-psa-jds-heading"> <span>Rheumatoid Arthritis & Psoriatic Arthritis</span>Joint Damage Simulator </div> <div class="dropdown js-simulator-select" data-select-main> <button class="btn dropdown-toggle" type="button" id="select-condition" data-bs-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> CHOOSE YOUR CONDITION </button> <div class="dropdown-menu" aria-labelledby="select-condition"> <a class="dropdown-item js-condition-option" href="##"" data-category="ra">Rheumatoid Arthritis (RA)</a> <a class="dropdown-item js-condition-option" href="##"" data-category="psa">Psoriatic Arthritis (PSA)</a> </div> </div> <div class="dropdown js-simulator-select" data-select-rel> <button class="btn dropdown-toggle" type="button" id="select-joins" data-bs-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> SELECT JOINT </button> <div class="dropdown-menu" aria-labelledby="select-joins"> <a class="dropdown-item js-simulator-option" data-value="hand" href="##"" data-category-obj='{"ra": "-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/jds/raHand-082024", "psa": "-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/jds/psaHand"}'>hand</a> <a class="dropdown-item js-simulator-option" data-value="foot" href="##"" data-category-obj='{"ra": "-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/jds/raFoot", "psa": "-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/jds/psaFoot"}'>foot</a> <a class="dropdown-item js-simulator-option" data-value="shoulder" href="##"" data-category-obj='{"ra": "-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/jds/raShoulder"}'>SHOULDER</a> <a class="dropdown-item js-simulator-option" data-value="knee" href="##"" data-category-obj='{"ra": "-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/jds/raKnee"}'>KNEE</a> </div> </div> </div> <div class="js-simulator-footer visible-on-start"> <p>* This is not intended to be a diagnostic tool. Progression of joint damage is unique for each individual patient. Images are for demonstration purposes only. Talk to your doctor about your symptoms. This tool does not collect or store your personal information, but Amgen may collect Usage Data to help us improve, develop, evaluate, and continue products, services, materials, and programs related to our products and your condition. Please read the Amgen <a class="privacy" href="https://www.amgen.com/privacy-statement" target="_blank">Privacy Statement</a> for more details. USA-916-80151 </p> </div> </div> <div class="js-simulator-example-holder"> <div class="js-simulator-example"></div> <div class="js-simulator-example-footer"> <p>Progression of joint damage is unique for each individual patient. Talk to your doctor about your symptoms. Images are for demonstration purposes only.</p> </div> </div> </div> </div> </section></h5> <h2> </h2> </div> </div> </div> </div> </div> </div> </div> <div class="component container full-width mtop max-width" id="side-effects"> <div class="component-content" > <div class="component promo"> <div class="component-content"> <div class="field-promotext"><div class="bor-left"><h2 class="heading3">POSSIBLE SIDE EFFECTS</h2></div> <p class="plr20"><b class="blue-color">Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).</b></p></div><div class="side-effect-1 enbrel-flex mb-20 mb20_mob"><div class="mobile-hide field-promoicon"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/plaque-psoriasis/group-10.svg?iar=0&hash=BF469EF056612657BF32C50B74C37612" class="lozad" alt="Injection site reactions from ENBREL®" data-variantfieldname="PromoIcon" data-src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/plaque-psoriasis/group-10.svg" data-variantitemid="{32DD4FAB-BE26-42B1-BAB5-979D5CA36CBB}" /></div><div class="mob-width field-promotext2"><div class="mobile-only mob-img"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/plaque-psoriasis/group-10.svg" alt="" data-variantitemid="{84E73A89-8B3D-4B93-A920-D73E8A23B156}" data-variantfieldname="PromoIcon" class="mobileOnly mb-20"></div> <p class="mb0">Injection site reactions can include redness, itching, pain, swelling, bleeding, or bruising. These symptoms usually go away within 3 to 5 days. If you have pain, redness, or swelling around the injection site that does not go away or gets worse, call your healthcare provider.</p> <div class="mobile-only mob-img"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/plaque-psoriasis/group-11.svg" alt="" data-variantitemid="{84E73A89-8B3D-4B93-A920-D73E8A23B156}" data-variantfieldname="PromoIcon2" class="mobileOnly mb-20"></div> </div></div><div class="side-effect-2 enbrel-flex mb-20 mb20_mob"><div class="mobile-hide field-promoicon2"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/plaque-psoriasis/group-11.svg?iar=0&hash=F9C334971BF4D406353D49A328A91A60" class="lozad" alt="Side effects of ENBREL®" data-variantfieldname="PromoIcon2" data-src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/plaque-psoriasis/group-11.svg" data-variantitemid="{32DD4FAB-BE26-42B1-BAB5-979D5CA36CBB}" /></div><div class="mob-width field-promotext3"><p>ENBREL can cause serious side effects including: New infections or worsening of infections you already have, including tuberculosis; lymphoma and other cancers; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis. See Important Safety Information below.</p> <p>For children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.</p></div></div> </div> </div> <div class="component promo Everybody-experience"> <div class="component-content"> <div class="enbrel-flex mb20_mob"><div class="mob-width field-promotext"><p>Everybody’s experience with ENBREL is different. It’s important to talk to your doctor about whether ENBREL is right for you and learn about its possible side effects.</p> <p><b><mark>Overall, out of the 3,743 people treated with ENBREL across clinical trials for different conditions<span class="asterisk ft-bold">*</span>, about 4% stopped using ENBREL due to side effects.</mark></b></p> <p class="footnote desktopOnly">*Rheumatoid arthritis, adult psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.</p></div><div class="mob-width field-promotext2"><div class="chart"> <div><img alt="4-Percent-Symbol" src="/-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Common/percent-4-symbol.svg"/></div> <p class="footnote mobileOnly">*Rheumatoid arthritis, adult psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.</p> </div></div></div> </div> </div> </div> </div> <div class="component container full-width talk-doc max-width" id="talk-to-your-doctor"> <div class="component-content" > <div class="component plain-html"> <div class="component-content"> <div class="bor-left"> <h1>TALKING TO <br class="mobileOnly">YOUR DOCTOR</h1> <h3>3 topics to bring up with your healthcare provider</h3> </div> <p class="pl-20 mobile-hide">Many doctors find the information below valuable when deciding on the right RA medication and treatment plan for their patients. <b style="color: black;">Make the most of your next doctor’s appointment</b> by preparing to discuss the following:</p> <p class="pl-20 mobile-only">Many doctors find the information below valuable when deciding on the right RA medication and treatment plan for their patients. <b style="color: black;">Make the most of your next doctor’s appointment</b> by preparing to discuss the following:</p> </div> </div> <div class="row component column-splitter"> <div class="col-12 col-sm-12 col-md-12 col-lg-4 col-xl-4 p0 white-bg"> <div class="component plain-html" id="cta-1"> <div class="component-content"> <h2>#1 How is rheumatoid arthritis making you feel overall?</h2> <p>Are the signs and symptoms of rheumatoid arthritis affecting your ability to complete everyday activities, like getting out of bed, walking upstairs, or running errands? Do you believe your current treatment plan is working well? Your doctor may run additional tests to confirm, but they will likely want your input as well.</p> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-4 col-xl-4 p0 white-bg"> <div class="component plain-html" id="cta-2"> <div class="component-content"> <h2>#2 Any new or worsening symptoms?</h2> <p>They could be a sign that your RA is progressing—and if that’s the case, your doctor may want to adjust your treatment plan.</p> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-4 col-xl-4 p0 white-bg"> <div class="component plain-html" id="cta-3"> <div class="component-content"> <h2>#3 How do your symptoms affect your daily activities?</h2> <p>Has getting out of bed, dressing yourself or walking up stairs become more difficult?</p> </div> </div> </div> </div> <div class=" quantum-cta " id=""> <a href="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Documents/Enbrel_Patient_RA_Doctor_Discussion_Guide_USA-916-83985.pdf" class=" quantum-cta__inner " custom-attr=" " data-click-type="download" data-click-text="download now - doctor discussion guide" target="_blank" > <div class="quantum-cta__image-wrap"> </div> <div class="quantum-cta__text"> <h2 class="quantum-cta__title">Get the Doctor Discussion Guide</h2> <p class="quantum-cta__copy">In addition to the topics above, this simple guide can help you have a more robust conversation with your doctor. </p> <button class="quantum-button quantum-cta__action " aria-label="" type="button"> <span class="quantum-button__text"> DOWNLOAD NOW </span> </button> </div> </a> </div> </div> </div> <div class="component container full-width mb20_mob cta-btn-image looking-for-support max-width" id="looking-for-support"> <div class="component-content" > <div class="component plain-html"> <div class="component-content"> <h2 class="blue-color">LOOKING FOR SUPPORT?</h2> </div> </div> <div class="row component column-splitter"> <div class="col-12 col-sm-12 col-md-12 col-lg-6 col-xl-6 p0 light-green-bg"> <div class="component promo col-12"> <div class="component-content"> <div class="promo-left-img"><div class="field-promoicon"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/plaque-psoriasis/group-11-copy.svg?iar=0&hash=1C544F7433A93F38D505EBAD35460D6F" class="lozad" alt="Amgen® SupportPlus" data-variantfieldname="PromoIcon" data-src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/plaque-psoriasis/group-11-copy.svg" data-variantitemid="{55350875-BE00-4334-9707-E540233C227D}" /></div><div class="field-promotext">Have a prescription? <br/>We can provide support.</div></div><div class="promo-text"><div class="field-promotext2">Whether you would like information on how to inject or have questions about support services, we can help.</div><div class="field-promolink"><a href="/support" data-variantitemid="{55350875-BE00-4334-9707-E540233C227D}" data-variantfieldname="PromoLink">Learn About Amgen® SupportPlus</a></div></div> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-6 col-xl-6 p0 light-green-bg"> <div class="component promo"> <div class="component-content"> <div class="promo-left-img"><div class="field-promoicon"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Icons/faqs-about-enbrel-new.svg?iar=0&hash=52F29ACF016BC7851AF1C97CED8ADF25" class="lozad" alt="FAQs about ENBREL®" data-variantfieldname="PromoIcon" data-src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Icons/faqs-about-enbrel-new.svg" data-variantitemid="{67E8D3B9-01C1-41ED-9CB6-10FC4A8D4357}" /></div><div class="field-promotext">More questions? <br/>Check out our FAQ.</div></div><div class="promo-text"><div class="field-promotext2">Have more questions about ENBREL? Check out our frequently asked questions.</div><div class="field-promolink"><a href="/taking-enbrel/faq" data-variantitemid="{67E8D3B9-01C1-41ED-9CB6-10FC4A8D4357}" data-variantfieldname="PromoLink">READ FAQs</a></div></div> </div> </div> </div> </div> </div> </div> <div id="fullIsi" class="demo-shell "> <div class="demo-shell__takeover"> <div class="quantum-isi-tray quantum-isi-tray--open"> <div class="quantum-isi-tray__trigger-wrap"> <div class="quantum-isi-tray__trigger-wrap-inner"> <button id="closesFullIsi" class="quantum-button quantum-isi-tray__trigger quantum-isi-tray__trigger--open quantum-button--small" type="button"> <span class="quantum-button__text"> Close </span> </button> </div> </div> <div class="quantum-isi-tray__inner"> <div class="quantum-isi-tray__content quantum-long-form-text"> <h3> </h3> <div class="quantum-isi-tray__content quantum-long-form-text"> <h3 style="display: none;"></h3> <div id="isi-header"> <p id="prescription-text">Prescription Enbrel<sup>®</sup> (etanercept) is taken (given) by injection.</p> <p class="quantum-h3 open-isi hide-desktop pb-0 show-desktop isi-title">IMPORTANT SAFETY INFORMATION</p> </div> <div class="quantum-isi-tray__content quantum-long-form-text"> <p class="isi-subtitle">What is the most important information I should know about ENBREL?</p> <p>ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.</p> <p>There have been some cases of unusual cancers, some resulting in death, reported in children and teenagers who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.</p> <div> <p class="isi-subtitle">Before starting ENBREL, tell your healthcare provider if you:</p> <ul> <li>Have any existing medical conditions</li> <li>Are taking any medicines, including herbals</li> <li>Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay</li> <li>Have any open cuts or sores</li> <li>Have diabetes, HIV, or a weak immune system</li> <li>Have TB or have been in close contact with someone who has had TB</li> <li>Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure</li> <li>Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider</li> <li>Have or have had hepatitis B</li> <li>Have or have had heart failure</li> <li>Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL</li> <li>Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)</li> <li>Are taking anti-diabetic medicines</li> <li>Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome </li> <li>Are scheduled to have surgery</li> <li>Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines</li> <li>Are pregnant, planning to become pregnant, or breastfeeding</li> <li>Have been around someone with chicken pox</li> </ul> </div> <div> <p class="isi-subtitle" id='enbrel-side-effects'>What are the possible side effects of ENBREL?</p> <p> ENBREL can cause serious side effects including: New <b>infections</b> or worsening of infections you already have; <b>hepatitis B</b> can become active if you already have had it; <b>nervous system problems</b>, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; <b>blood problems</b> (some fatal); new or worsening <b>heart failure</b>; new or worsening psoriasis; <b>allergic reactions; autoimmune reactions</b>, including a lupus-like syndrome and autoimmune hepatitis. </p> <p><b>Common side effects include:</b> Injection site reactions and upper respiratory infections (sinus infections).</p> <p>In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.</p> <p>These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.</p> <p>If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a class="isi-link" href="https://www.fda.gov/medwatch" target="_blank">www.fda.gov/medwatch</a>, or call <span class="text-nowrap">1-800-FDA-1088.</span></p> <p>Please see <a class="isi-link" href="https://www.pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf" target="_blank">Prescribing Information</a> and <a class="isi-link" href="https://www.pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf" target="_blank">Medication Guide</a>.</p> </div> <div id="isi-indication"> <h3 class="quantum-h3 open-isi hide-desktop pb-0 show-desktop isi-title">INDICATIONS</h3> <p>ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.</p> <p>ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (pJIA) in children 2 years of age or older.</p> <p>ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in adult patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.</p> <p>ENBREL is indicated for active juvenile psoriatic arthritis (JPsA) in children 2 years of age or older.</p> <p>ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.</p> <p>ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years of age or older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).</p> </div> </div> </div> </div> </div> </div> </div> <div class="demo-shell__fixed-bottom" id="IsiBottomTray"> <div class="quantum-isi-tray quantum-isi-tray--closed"> <div class="quantum-isi-tray__trigger-wrap"> <div class="quantum-isi-tray__trigger-wrap-inner"> </div> </div> <div class="quantum-isi-tray__inner"> <div class="quantum-isi-tray__content-preview quantum-long-form-text"> <button id="opensFullIsi" class="quantum-button quantum-isi-tray__trigger quantum-isi-tray__trigger--closed quantum-button--small" type="button"> <span class="quantum-button__text"> Open </span> </button> <h5> </h5> <div id="isi-header"> <p id="prescription-text" class="desktopOnly">Prescription Enbrel<sup>®</sup> (etanercept) is taken (given) by injection.</p> <p class="quantum-h3 open-isi hide-desktop pb-0 show-desktop isi-title">IMPORTANT SAFETY INFORMATION</p> </div> <div class="quantum-isi-tray__content quantum-long-form-text"> <p class="isi-subtitle">What is the most important information I should know about ENBREL?</p> <p>ENBREL is a medicine that affects your immune system. 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