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ENBREL® (etanercept) | Official Patient Site

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See Full Prescribing & Safety Info." property="og:description" /><meta content="website" property="og:type" /><meta content="https://www.enbrel.com/-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Logos/enbrel-logo.png" property="og:image" /><meta content="ENBREL® (etanercept) | Official Patient Site" property="og:title" /><meta content="https://www.enbrel.com" property="og:url" /> <meta content="Learn about Enbrel® (etanercept), a treatment option for autoimmune diseases like moderate to severe rheumatoid arthritis and psoriatic arthritis. See Full Prescribing & Safety Info." name="description" /> <meta content="Home" name="twitter:title" /><meta content="summary_large_image" name="twitter:card" /> <meta name="viewport" content="width=device-width, initial-scale=1"/> <link rel="alternate" hreflang="en" href="http://www.enbrel.com/" /> <meta content="https://www.enbrel.com" name="twitter:url" /> <link rel="canonical" href="https://www.enbrel.com"> <script>dataLayer = [{'pageType':'home','siteSection':'home','contentType':'patient'}];</script> <!-- Google Tag Manager --> <script> (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window, document, 'script', 'dataLayer', 'GTM-KRDMH8'); </script> <!-- End Google Tag Manager --> </head> <body class="r-library page-home default-device bodyclass" data-language="en"> <!-- Google Tag Manager (noscript) --> <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-KRDMH8" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript> <!-- End Google Tag Manager (noscript) --> <div id="fb-root"></div> <div id="wrapper"> </div> <header class="header-nav"> <div class="quantum-container--light quantum-indications " id=""> <div class="quantum-indications__inner"> <h6 class="quantum-indications__title">Indications</h6> <p class="quantum-indications__copy quantum-text quantum-text--small"> <span class="medium">ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.</span> <span class="readmore"><a href="javascript:void(0);" class="quantum-link quantum-indications__read-more-link seeMore">Read more</a></span> </p> <div class="quantum-indications__copy quantum-indications__copy--read-more quantum-long-form-text" style="display: none;"> <p> <span class="medium">ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.</span> </p> <p> <span class="medium">ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years of age or older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).</span> </p> <p> <span class="medium">ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in adult patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.</span> </p> <p> <span class="medium">ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.</span> </p> <p> <span class="medium">ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (pJIA) in children 2 years of age or older.</span> </p> <p class="mb-0"> <span class="medium">ENBREL is indicated for active juvenile psoriatic arthritis (JPsA) in children 2 years of age or older.</span> </p> <p class="indiction-close"><a href="javascript:void(0);" class="quantum-link quantum-indications__read-less-link seeLess">close</a></p> </div> <button class="quantum-button quantum-button--tertiary quantum-indications__close quantum-button--icon-only" id="indicationClose" type="button"> <svg class="quantum-icon quantum-button__icon"> <use 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alt="" /> </button> <span class="quantum-search-clear"> </span> <button class="quantum-search-btn-close">X</button> <input type="hidden" id="searchtag" name="tag" value="" /> </div> </div> <div class="quantum-top-nav quantum-container--primary " id="top-navigation-full-website"> <div class="quantum-top-nav__inner"> <div class="quantum-top-nav__links quantum-drop-down-menu"> <ul class="quantum-drop-down-menu__list"> <li class="quantum-drop-down-menu__list-item"> <a href="https://www.pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf" class=" gtm-topNavCl quantum-top-nav__link " target="_blank" menu-name="prescribing info" menu-type="top header" data-click-type="download" data-click-text="prescribing info"> <span class="quantum-top-nav__link-text">Prescribing Information</span> </a> </li> <li class="quantum-drop-down-menu__list-item"> <a href="https://www.pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf" class=" gtm-topNavCl quantum-top-nav__link " target="_blank" 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d-md-block"> <button class="btn__animated blue-btn dropdown-toggle" type="button" id="dropdownMenuButton" data-bs-toggle="dropdown" aria-haspopup="true" aria-expanded="false">CHOOSE YOUR CONDITION</button> <div class="dropdown-menu" aria-labelledby="dropdownMenuButton" style="will-change: transform;"> <ul class="home-top-nav-condition"> <li><span>Moderate to Severe</span><br> <a class="dropdown-item" href="/rheumatoid-arthritis" data-click-type="promo" data-click-text="Rheumatoid Arthritis" condition="ra">Rheumatoid Arthritis</a></li> <li><a class="dropdown-item" href="/psoriatic-arthritis" data-click-type="promo" data-click-text="Adult Psoriatic Arthritis" condition="psa">Adult Psoriatic Arthritis</a></li> <li><a class="dropdown-item" href="/ankylosing-spondylitis" data-click-type="promo" data-click-text="Ankylosing Spondylitis" condition="as">Ankylosing Spondylitis</a></li> <li><span class="d-block">Moderate to Severe Polyarticular</span> <a class="dropdown-item" href="/juvenile-idiopathic-arthritis" data-click-type="promo" data-click-text="Juvenile Idiopathic Arthritis" condition="jia">Juvenile Idiopathic Arthritis</a></li> <li><span>Moderate to Severe</span> <br> <a class="dropdown-item" href="/plaque-psoriasis" data-click-type="promo" data-click-text="Plaque Psoriasis" condition="pso">Plaque Psoriasis</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> <div class="component container full-width max-width personalized-support"> <div class="component-content" > <div class="component promo col-12" id="promocard"> <div class="component-content"> <div class="enbrel-flex mb20_mob"><div class="promo-left-column"><div class="mob-width field-promotext"><h3> Pay as little as $0<sup>*</sup></h3> <p>The ENBREL Co-Pay Program may help eligible patients with <br class="desktop-only">commercial insurance (usually self-purchased or through an employer)<br class="desktop-only"> lower their out-of-pocket costs for ENBREL.</p> <ul> <li>Pay as little as $0* out-of-pocket for each dose</li> <li>Can be applied to deductible, co-insurance, and co-payment*</li> <li> Support available regardless of income level</li> </ul> <p>First time using a co-pay card? <a href="/support" data-click-type='promo' data-click-text='find out more'>Find out more</a> about how it can help you.</p> <p>No insurance? <a href="/paying-for-enbrel" data-click-type='promo' data-click-text='learn about'>Learn about</a> other ways to access ENBREL.</p> <p class="footnote">*Eligibility criteria and program maximums apply. See <a href="https://www.amgensupportplus.com/copay-terms" target="_blank" data-click-type="outbound" data-click-text="AmgenSupportPlus.com/copay-terms">AmgenSupportPlus.com/copay-terms</a> for full Terms and Conditions.</p> </div></div><div class="promo-right-column"><div class="mob-width mobile-hide field-promoicon"><img src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/Home/copay-card-mobile.png?h=295&amp;iar=0&amp;w=376&amp;hash=5470C108149A0D14CDD263404BEE7F52" class="lozad" alt="Enbrel-Amgensupport-M" width="376" height="295" data-variantfieldname="PromoIcon" data-src="-/media/Themes/Amgen/Enbrel-com-Redesign-new/Enbrel-com-Redesign-new/Images/Content/Dekstop/Home/copay-card-mobile.png" data-variantitemid="{92C5E68B-F923-4F97-AB3A-430503BFEF99}" /></div><div class="mob-width field-promolink"><a href="/support#enrollment" data-variantitemid="{92C5E68B-F923-4F97-AB3A-430503BFEF99}" data-variantfieldname="PromoLink">Sign Up</a></div></div></div><div class="row component"></div> </div> </div> </div> </div> <div id="fullIsi" class="demo-shell "> <div class="demo-shell__takeover"> <div class="quantum-isi-tray quantum-isi-tray--open"> <div class="quantum-isi-tray__trigger-wrap"> <div class="quantum-isi-tray__trigger-wrap-inner"> <button id="closesFullIsi" class="quantum-button quantum-isi-tray__trigger quantum-isi-tray__trigger--open quantum-button--small" type="button"> <span class="quantum-button__text"> Close </span> </button> </div> </div> <div class="quantum-isi-tray__inner"> <div class="quantum-isi-tray__content quantum-long-form-text"> <h3> </h3> <div class="quantum-isi-tray__content quantum-long-form-text"> <h3 style="display: none;"></h3> <div id="isi-header"> <p id="prescription-text">Prescription Enbrel<sup>®</sup> (etanercept) is taken (given) by injection.</p> <p class="quantum-h3 open-isi hide-desktop pb-0 show-desktop isi-title">IMPORTANT SAFETY INFORMATION</p> </div> <div class="quantum-isi-tray__content quantum-long-form-text"> <p class="isi-subtitle">What is the most important information I should know about ENBREL?</p> <p>ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.</p> <p>There have been some cases of unusual cancers, some resulting in death, reported in children and teenagers who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.</p> <div> <p class="isi-subtitle">Before starting ENBREL, tell your healthcare provider if you:</p> <ul> <li>Have any existing medical conditions</li> <li>Are taking any medicines, including herbals</li> <li>Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay</li> <li>Have any open cuts or sores</li> <li>Have diabetes, HIV, or a weak immune system</li> <li>Have TB or have been in close contact with someone who has had TB</li> <li>Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure</li> <li>Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider</li> <li>Have or have had hepatitis B</li> <li>Have or have had heart failure</li> <li>Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL</li> <li>Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)</li> <li>Are taking anti-diabetic medicines</li> <li>Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome </li> <li>Are scheduled to have surgery</li> <li>Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines</li> <li>Are pregnant, planning to become pregnant, or breastfeeding</li> <li>Have been around someone with chicken pox</li> </ul> </div> <div> <p class="isi-subtitle" id='enbrel-side-effects'>What are the possible side effects of ENBREL?</p> <p> ENBREL can cause serious side effects including: New <b>infections</b> or worsening of infections you already have; <b>hepatitis B</b> can become active if you already have had it; <b>nervous system problems</b>, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; <b>blood problems</b> (some fatal); new or worsening <b>heart failure</b>; new or worsening psoriasis; <b>allergic reactions; autoimmune reactions</b>, including a lupus-like syndrome and autoimmune hepatitis. </p> <p><b>Common side effects include:</b> Injection site reactions and upper respiratory infections (sinus infections).</p> <p>In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.</p> <p>These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.</p> <p>If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a class="isi-link" href="https://www.fda.gov/medwatch" target="_blank">www.fda.gov/medwatch</a>, or call <span class="text-nowrap">1-800-FDA-1088.</span></p> <p>Please see <a class="isi-link" href="https://www.pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf" target="_blank">Prescribing Information</a> and <a class="isi-link" href="https://www.pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf" target="_blank">Medication Guide</a>.</p> </div> <div id="isi-indication"> <h3 class="quantum-h3 open-isi hide-desktop pb-0 show-desktop isi-title">INDICATIONS</h3> <p>ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.</p> <p>ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (pJIA) in children 2 years of age or older.</p> <p>ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in adult patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.</p> <p>ENBREL is indicated for active juvenile psoriatic arthritis (JPsA) in children 2 years of age or older.</p> <p>ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.</p> <p>ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years of age or older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).</p> </div> </div> </div> </div> </div> </div> </div> <div class="demo-shell__fixed-bottom" id="IsiBottomTray"> <div class="quantum-isi-tray quantum-isi-tray--closed"> <div class="quantum-isi-tray__trigger-wrap"> <div class="quantum-isi-tray__trigger-wrap-inner"> </div> </div> <div class="quantum-isi-tray__inner"> <div class="quantum-isi-tray__content-preview quantum-long-form-text"> <button id="opensFullIsi" class="quantum-button quantum-isi-tray__trigger quantum-isi-tray__trigger--closed quantum-button--small" type="button"> <span class="quantum-button__text"> Open </span> </button> <h5> </h5> <div id="isi-header"> <p id="prescription-text" class="desktopOnly">Prescription Enbrel<sup>®</sup> (etanercept) is taken (given) by injection.</p> <p class="quantum-h3 open-isi hide-desktop pb-0 show-desktop isi-title">IMPORTANT SAFETY INFORMATION</p> </div> <div class="quantum-isi-tray__content quantum-long-form-text"> <p class="isi-subtitle">What is the most important information I should know about ENBREL?</p> <p>ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your <span class="desktopOnly">immune system to fight infections.</span> <!--Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. 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