CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Luis Barreto | National Research Council Canada - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="Vrlhb8YgG5VAp1B1Rt7+N+XP3t5WZKUwv1z9ObkUKQH9DPjJJQ2eLEjYSkmjuvPq7GkBAy06jHAbi7A7ZBQYhg==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-1c712297ae3ac71207193b1bae0ecf1aae125886850f62c9c0139dd867630797.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="luis barreto" /> <meta name="description" content="Luis Barreto, National Research Council Canada: 14 Followers, 4 Following, 45 Research papers. Research interests: Human, Preventive medicine, and Publications." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15276,"monthly_visitors":"112 million","monthly_visitor_count":112794806,"monthly_visitor_count_in_millions":112,"user_count":277177611,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1732448508000); window.Aedu.timeDifference = new Date().getTime() - 1732448508000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-296162c7af6fd81dcdd76f1a94f1fad04fb5f647401337d136fe8b68742170b1.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-8d53a22151f33ab413d88fa1c02f979c3f8706d470fc1bced09852c72a9f3454.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-f8fe82512740391f81c9e8cc48220144024b425b359b08194e316f4de070b9e8.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://nrc-ca.academia.edu/LuisBarreto" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-9601d1cc3d68aa07c0a9901d03d3611aec04cc07d2a2039718ebef4ad4d148ca.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png","has_photo":false,"department":{"id":966321,"name":"Human Health Therapeutics","url":"https://nrc-ca.academia.edu/Departments/Human_Health_Therapeutics/Documents","university":{"id":5457,"name":"National Research Council Canada","url":"https://nrc-ca.academia.edu/"}},"position":"Special Advisor, Vaccine Program","position_id":4,"is_analytics_public":false,"interests":[{"id":41720,"name":"Human","url":"https://www.academia.edu/Documents/in/Human"},{"id":13084,"name":"Preventive medicine","url":"https://www.academia.edu/Documents/in/Preventive_medicine"},{"id":288126,"name":"Publications","url":"https://www.academia.edu/Documents/in/Publications"},{"id":12977,"name":"Consequentialism","url":"https://www.academia.edu/Documents/in/Consequentialism"},{"id":330953,"name":"Longitudinal Studies","url":"https://www.academia.edu/Documents/in/Longitudinal_Studies"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://nrc-ca.academia.edu/LuisBarreto","location":"/LuisBarreto","scheme":"https","host":"nrc-ca.academia.edu","port":null,"pathname":"/LuisBarreto","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-cddaa010-36c2-4488-b993-cada5ea77c16"></div> <div id="ProfileCheckPaperUpdate-react-component-cddaa010-36c2-4488-b993-cada5ea77c16"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Luis Barreto</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://nrc-ca.academia.edu/">National Research Council Canada</a>, <a class="u-tcGrayDarker" href="https://nrc-ca.academia.edu/Departments/Human_Health_Therapeutics/Documents">Human Health Therapeutics</a>, <span class="u-tcGrayDarker">Special Advisor, Vaccine Program</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Luis" data-follow-user-id="38584614" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="38584614"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">14</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">4</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">4</p></div></a><a href="/LuisBarreto/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data">1</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38584614" href="https://www.academia.edu/Documents/in/Human"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://nrc-ca.academia.edu/LuisBarreto","location":"/LuisBarreto","scheme":"https","host":"nrc-ca.academia.edu","port":null,"pathname":"/LuisBarreto","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Human"]}" data-trace="false" data-dom-id="Pill-react-component-662a44b8-5e0c-4ddc-94de-dabe69b999cb"></div> <div id="Pill-react-component-662a44b8-5e0c-4ddc-94de-dabe69b999cb"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38584614" href="https://www.academia.edu/Documents/in/Preventive_medicine"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Preventive medicine"]}" data-trace="false" data-dom-id="Pill-react-component-ff166ca5-6313-4423-956a-cd726f47fd7b"></div> <div id="Pill-react-component-ff166ca5-6313-4423-956a-cd726f47fd7b"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38584614" href="https://www.academia.edu/Documents/in/Publications"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Publications"]}" data-trace="false" data-dom-id="Pill-react-component-e544635b-7661-4a6a-b30d-4feb10f3e856"></div> <div id="Pill-react-component-e544635b-7661-4a6a-b30d-4feb10f3e856"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38584614" href="https://www.academia.edu/Documents/in/Consequentialism"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Consequentialism"]}" data-trace="false" data-dom-id="Pill-react-component-ff775779-35f5-469b-bbfa-33c09aa3ce49"></div> <div id="Pill-react-component-ff775779-35f5-469b-bbfa-33c09aa3ce49"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38584614" href="https://www.academia.edu/Documents/in/Longitudinal_Studies"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Longitudinal Studies"]}" data-trace="false" data-dom-id="Pill-react-component-469a9e9d-c014-4819-8624-cf3487dca4e9"></div> <div id="Pill-react-component-469a9e9d-c014-4819-8624-cf3487dca4e9"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Luis Barreto</h3></div><div class="js-work-strip profile--work_container" data-work-id="125340432"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125340432/Immunogenicity_and_safety_of_a_recombinant_adenovirus_type_5_vectored_COVID_19_vaccine_in_healthy_adults_aged_18_years_or_older_a_randomised_double_blind_placebo_controlled_phase_2_trial"><img alt="Research paper thumbnail of Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial" class="work-thumbnail" src="https://attachments.academia-assets.com/119402386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125340432/Immunogenicity_and_safety_of_a_recombinant_adenovirus_type_5_vectored_COVID_19_vaccine_in_healthy_adults_aged_18_years_or_older_a_randomised_double_blind_placebo_controlled_phase_2_trial">Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial</a></div><div class="wp-workCard_item"><span>The Lancet</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b85fd78a8e4b5673552f5e5246e5d41a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":119402386,"asset_id":125340432,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/119402386/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125340432"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="125340432"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 125340432; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125340432]").text(description); $(".js-view-count[data-work-id=125340432]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 125340432; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='125340432']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 125340432, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b85fd78a8e4b5673552f5e5246e5d41a" } } $('.js-work-strip[data-work-id=125340432]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":125340432,"title":"Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"The Lancet"},"translated_abstract":null,"internal_url":"https://www.academia.edu/125340432/Immunogenicity_and_safety_of_a_recombinant_adenovirus_type_5_vectored_COVID_19_vaccine_in_healthy_adults_aged_18_years_or_older_a_randomised_double_blind_placebo_controlled_phase_2_trial","translated_internal_url":"","created_at":"2024-11-06T16:00:34.982-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":119402386,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/119402386/thumbnails/1.jpg","file_name":"main.pdf","download_url":"https://www.academia.edu/attachments/119402386/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immunogenicity_and_safety_of_a_recombina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/119402386/main-libre.pdf?1730959458=\u0026response-content-disposition=attachment%3B+filename%3DImmunogenicity_and_safety_of_a_recombina.pdf\u0026Expires=1732452107\u0026Signature=HY7NrWd4mgGf-5CLdRGJFNT51TCK5Dsl~lUg3U9jaKZ~cmoCp3d9E-AXjYYjd-AKH4NXcXhmH27LzZfMg9BJGO2jcwlVAGJrx0E~L1v2JEQAw3xe1trWT79-0hhsOiirevC1zJZ-lFGPj~1NxXYFq2CqrH0-gm7nY6i32EaOmx4-VpaSAXijTcjq5OPEuVIk94bR8S7xYnQdWLA7mJIEQr2oQrNjvqPyW3Tbb56eIPeCiI1s3c8NallX9uo0Wxlq9A9IPQlvOZCdfwIkwOI2~UTcmcFu-DnFbRmiPlCteT9DJM2nh3v3jUBx-3Vzq3ZLlXzy6UrbHKzC5~ZJDOFgsg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Immunogenicity_and_safety_of_a_recombinant_adenovirus_type_5_vectored_COVID_19_vaccine_in_healthy_adults_aged_18_years_or_older_a_randomised_double_blind_placebo_controlled_phase_2_trial","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":119402386,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/119402386/thumbnails/1.jpg","file_name":"main.pdf","download_url":"https://www.academia.edu/attachments/119402386/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immunogenicity_and_safety_of_a_recombina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/119402386/main-libre.pdf?1730959458=\u0026response-content-disposition=attachment%3B+filename%3DImmunogenicity_and_safety_of_a_recombina.pdf\u0026Expires=1732452107\u0026Signature=HY7NrWd4mgGf-5CLdRGJFNT51TCK5Dsl~lUg3U9jaKZ~cmoCp3d9E-AXjYYjd-AKH4NXcXhmH27LzZfMg9BJGO2jcwlVAGJrx0E~L1v2JEQAw3xe1trWT79-0hhsOiirevC1zJZ-lFGPj~1NxXYFq2CqrH0-gm7nY6i32EaOmx4-VpaSAXijTcjq5OPEuVIk94bR8S7xYnQdWLA7mJIEQr2oQrNjvqPyW3Tbb56eIPeCiI1s3c8NallX9uo0Wxlq9A9IPQlvOZCdfwIkwOI2~UTcmcFu-DnFbRmiPlCteT9DJM2nh3v3jUBx-3Vzq3ZLlXzy6UrbHKzC5~ZJDOFgsg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":72938,"name":"Placebo","url":"https://www.academia.edu/Documents/in/Placebo"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":259819,"name":"Recombinant DNA","url":"https://www.academia.edu/Documents/in/Recombinant_DNA"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":2056374,"name":"Seroconversion","url":"https://www.academia.edu/Documents/in/Seroconversion"},{"id":2601211,"name":"Adverse effect","url":"https://www.academia.edu/Documents/in/Adverse_effect"},{"id":3094070,"name":"The Lancet","url":"https://www.academia.edu/Documents/in/The_Lancet"},{"id":3686510,"name":"Coronavirus Disease 2019 (COVID-19)","url":"https://www.academia.edu/Documents/in/Coronavirus_Disease_2019_COVID-19_"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":45497908,"url":"https://api.elsevier.com/content/article/PII:S0140673620316056?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110584469"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110584469/The_Pediatric_Infectious_Disease_Journal"><img alt="Research paper thumbnail of The Pediatric Infectious Disease Journal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110584469/The_Pediatric_Infectious_Disease_Journal">The Pediatric Infectious Disease Journal</a></div><div class="wp-workCard_item"><span>The Pediatric Infectious Disease Journal</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Pediatr Infect Dis J. 2014 Aug 14. [Epub ahead of print] Human Parechovirus Infection in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Pediatr Infect Dis J. 2014 Aug 14. [Epub ahead of print] Human Parechovirus Infection in Neonatal Intensive Care. Davis J1, Fairley D, Christie S, Coyle P, Tubman R, Shields MD. Author information Abstract BACKGROUND:: Approximately 5-6% of all infective episodes in NICU are of viral origin. Previous studies suggest that human parechovirus (HPeV) infection presents most commonly in term infants, as a sepsis-like syndrome in which meningoencephalitis is prominent. Our aim was to study the infection rate and associated features of HPeV. METHODS:: Blood samples were taken from NICU babies greater than 48 hours old, who were being investigated for late onset sepsis. Clinical and laboratory data were collected at the time of the suspected sepsis episode. Samples were tested using universal primers and probe directed at the 5&amp;amp;#39;-untranslated region of the HPeV genome by reverse transcriptase PCR. Results were confirmed by electrophoresis and DNA sequencing. RESULTS:: HPeV was detected in 11 of 84 samples (13%). These infants had a mean (interquartile range, IQR) gestational age of 28.9 (26.9 - 30.6) weeks and mean birth weight of 1.26 (SD = 0.72) kg. The median day of presentation was 16 (IQR: 11-27). These characteristics were similar to the infants without positive viral detection. Six infants presented with respiratory signs. One infant presented with signs of meningitis. Six of the 11 episodes of HPeV infection occurred during the winter months (December - February). No HPeV positive infants had abnormal findings on their 28-day cranial ultrasound examination. CONCLUSIONS:: We found a HPeV infection rate of 13% in infants being tested for late onset sepsis. HPeV should be considered as a possible cause of sepsis-like symptoms in preterm infants.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110584469"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110584469"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110584469; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110584469]").text(description); $(".js-view-count[data-work-id=110584469]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110584469; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110584469']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110584469, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=110584469]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110584469,"title":"The Pediatric Infectious Disease Journal","translated_title":"","metadata":{"abstract":"ABSTRACT Pediatr Infect Dis J. 2014 Aug 14. [Epub ahead of print] Human Parechovirus Infection in Neonatal Intensive Care. Davis J1, Fairley D, Christie S, Coyle P, Tubman R, Shields MD. Author information Abstract BACKGROUND:: Approximately 5-6% of all infective episodes in NICU are of viral origin. Previous studies suggest that human parechovirus (HPeV) infection presents most commonly in term infants, as a sepsis-like syndrome in which meningoencephalitis is prominent. Our aim was to study the infection rate and associated features of HPeV. METHODS:: Blood samples were taken from NICU babies greater than 48 hours old, who were being investigated for late onset sepsis. Clinical and laboratory data were collected at the time of the suspected sepsis episode. Samples were tested using universal primers and probe directed at the 5\u0026amp;amp;#39;-untranslated region of the HPeV genome by reverse transcriptase PCR. Results were confirmed by electrophoresis and DNA sequencing. RESULTS:: HPeV was detected in 11 of 84 samples (13%). These infants had a mean (interquartile range, IQR) gestational age of 28.9 (26.9 - 30.6) weeks and mean birth weight of 1.26 (SD = 0.72) kg. The median day of presentation was 16 (IQR: 11-27). These characteristics were similar to the infants without positive viral detection. Six infants presented with respiratory signs. One infant presented with signs of meningitis. Six of the 11 episodes of HPeV infection occurred during the winter months (December - February). No HPeV positive infants had abnormal findings on their 28-day cranial ultrasound examination. CONCLUSIONS:: We found a HPeV infection rate of 13% in infants being tested for late onset sepsis. HPeV should be considered as a possible cause of sepsis-like symptoms in preterm infants.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1991,"errors":{}},"publication_name":"The Pediatric Infectious Disease Journal"},"translated_abstract":"ABSTRACT Pediatr Infect Dis J. 2014 Aug 14. [Epub ahead of print] Human Parechovirus Infection in Neonatal Intensive Care. Davis J1, Fairley D, Christie S, Coyle P, Tubman R, Shields MD. Author information Abstract BACKGROUND:: Approximately 5-6% of all infective episodes in NICU are of viral origin. Previous studies suggest that human parechovirus (HPeV) infection presents most commonly in term infants, as a sepsis-like syndrome in which meningoencephalitis is prominent. Our aim was to study the infection rate and associated features of HPeV. METHODS:: Blood samples were taken from NICU babies greater than 48 hours old, who were being investigated for late onset sepsis. Clinical and laboratory data were collected at the time of the suspected sepsis episode. Samples were tested using universal primers and probe directed at the 5\u0026amp;amp;#39;-untranslated region of the HPeV genome by reverse transcriptase PCR. Results were confirmed by electrophoresis and DNA sequencing. RESULTS:: HPeV was detected in 11 of 84 samples (13%). These infants had a mean (interquartile range, IQR) gestational age of 28.9 (26.9 - 30.6) weeks and mean birth weight of 1.26 (SD = 0.72) kg. The median day of presentation was 16 (IQR: 11-27). These characteristics were similar to the infants without positive viral detection. Six infants presented with respiratory signs. One infant presented with signs of meningitis. Six of the 11 episodes of HPeV infection occurred during the winter months (December - February). No HPeV positive infants had abnormal findings on their 28-day cranial ultrasound examination. CONCLUSIONS:: We found a HPeV infection rate of 13% in infants being tested for late onset sepsis. HPeV should be considered as a possible cause of sepsis-like symptoms in preterm infants.","internal_url":"https://www.academia.edu/110584469/The_Pediatric_Infectious_Disease_Journal","translated_internal_url":"","created_at":"2023-12-04T18:10:59.905-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Pediatric_Infectious_Disease_Journal","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":81309,"name":"Infectious Disease","url":"https://www.academia.edu/Documents/in/Infectious_Disease"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":36456990,"url":"http://journals.lww.com/00006454-199110000-00020"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863971"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863971/Acellular_pertussis_vaccines_and_methods_for_their_preparation"><img alt="Research paper thumbnail of Acellular pertussis vaccines and methods for their preparation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863971/Acellular_pertussis_vaccines_and_methods_for_their_preparation">Acellular pertussis vaccines and methods for their preparation</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863971"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863971"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863971; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863971]").text(description); $(".js-view-count[data-work-id=105863971]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863971; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863971']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863971, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105863971]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863971,"title":"Acellular pertussis vaccines and methods for their preparation","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1996,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/105863971/Acellular_pertussis_vaccines_and_methods_for_their_preparation","translated_internal_url":"","created_at":"2023-08-22T18:42:20.036-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Acellular_pertussis_vaccines_and_methods_for_their_preparation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863970"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863970/Humoral_immunity_10_years_after_booster_immunization_with_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine"><img alt="Research paper thumbnail of Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863970/Humoral_immunity_10_years_after_booster_immunization_with_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine">Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863970"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863970"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863970; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863970]").text(description); $(".js-view-count[data-work-id=105863970]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863970; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863970']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863970, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105863970]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863970,"title":"Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Vaccine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/105863970/Humoral_immunity_10_years_after_booster_immunization_with_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine","translated_internal_url":"","created_at":"2023-08-22T18:42:19.728-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Humoral_immunity_10_years_after_booster_immunization_with_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":136892,"name":"Immunization","url":"https://www.academia.edu/Documents/in/Immunization"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":150847,"name":"Vaccine","url":"https://www.academia.edu/Documents/in/Vaccine"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors"},{"id":600942,"name":"Tetanus","url":"https://www.academia.edu/Documents/in/Tetanus"},{"id":1490453,"name":"Whooping Cough","url":"https://www.academia.edu/Documents/in/Whooping_Cough"},{"id":1817270,"name":"Diphtheria","url":"https://www.academia.edu/Documents/in/Diphtheria"},{"id":2584909,"name":"Antitoxin","url":"https://www.academia.edu/Documents/in/Antitoxin"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":33566260,"url":"https://api.elsevier.com/content/article/PII:S0264410X12001788?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863969"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863969/A_review_of_invasiveHaemophilus_influenzaedisease_in_the_Indigenous_populations_of_North_America"><img alt="Research paper thumbnail of A review of invasiveHaemophilus influenzaedisease in the Indigenous populations of North America" class="work-thumbnail" src="https://attachments.academia-assets.com/105214905/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863969/A_review_of_invasiveHaemophilus_influenzaedisease_in_the_Indigenous_populations_of_North_America">A review of invasiveHaemophilus influenzaedisease in the Indigenous populations of North America</a></div><div class="wp-workCard_item"><span>Epidemiology and Infection</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">SUMMARYHistorically, the highest incidence rates of invasiveHaemophilus influenzaedisease in the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">SUMMARYHistorically, the highest incidence rates of invasiveHaemophilus influenzaedisease in the world were found in North American and Australian Indigenous children. Although immunization againstH. influenzaetype b (Hib) led to a marked decrease in invasive Hib disease in countries where it was implemented, this disease has not been eliminated and its rates in Indigenous communities remain higher than in the general North American population. In this literature review, we examined the epidemiology of invasiveH. influenzaedisease in the pre-Hib vaccine era, effect of carriage on disease epidemiology, immune response toH. influenzaeinfection and Hib vaccination in Indigenous and Caucasian children, and the changing epidemiology after Hib conjugate vaccine has been in use for more than two decades in North America. We also explored reasons behind the continued high rates of invasiveH. influenzaedisease in Indigenous populations in North America.H. influenzaetype a (Hia) has emerged a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3335b14a8a5c9338ce08c8516d6f85d9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105214905,"asset_id":105863969,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105214905/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863969"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863969"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863969; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863969]").text(description); $(".js-view-count[data-work-id=105863969]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863969; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863969']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863969, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3335b14a8a5c9338ce08c8516d6f85d9" } } $('.js-work-strip[data-work-id=105863969]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863969,"title":"A review of invasiveHaemophilus influenzaedisease in the Indigenous populations of North America","translated_title":"","metadata":{"abstract":"SUMMARYHistorically, the highest incidence rates of invasiveHaemophilus influenzaedisease in the world were found in North American and Australian Indigenous children. Although immunization againstH. influenzaetype b (Hib) led to a marked decrease in invasive Hib disease in countries where it was implemented, this disease has not been eliminated and its rates in Indigenous communities remain higher than in the general North American population. In this literature review, we examined the epidemiology of invasiveH. influenzaedisease in the pre-Hib vaccine era, effect of carriage on disease epidemiology, immune response toH. influenzaeinfection and Hib vaccination in Indigenous and Caucasian children, and the changing epidemiology after Hib conjugate vaccine has been in use for more than two decades in North America. We also explored reasons behind the continued high rates of invasiveH. influenzaedisease in Indigenous populations in North America.H. influenzaetype a (Hia) has emerged a...","publisher":"Cambridge University Press (CUP)","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Epidemiology and Infection"},"translated_abstract":"SUMMARYHistorically, the highest incidence rates of invasiveHaemophilus influenzaedisease in the world were found in North American and Australian Indigenous children. Although immunization againstH. influenzaetype b (Hib) led to a marked decrease in invasive Hib disease in countries where it was implemented, this disease has not been eliminated and its rates in Indigenous communities remain higher than in the general North American population. In this literature review, we examined the epidemiology of invasiveH. influenzaedisease in the pre-Hib vaccine era, effect of carriage on disease epidemiology, immune response toH. influenzaeinfection and Hib vaccination in Indigenous and Caucasian children, and the changing epidemiology after Hib conjugate vaccine has been in use for more than two decades in North America. We also explored reasons behind the continued high rates of invasiveH. influenzaedisease in Indigenous populations in North America.H. influenzaetype a (Hia) has emerged a...","internal_url":"https://www.academia.edu/105863969/A_review_of_invasiveHaemophilus_influenzaedisease_in_the_Indigenous_populations_of_North_America","translated_internal_url":"","created_at":"2023-08-22T18:42:19.463-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":105214905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214905/thumbnails/1.jpg","file_name":"S0950268814000405.pdf","download_url":"https://www.academia.edu/attachments/105214905/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_review_of_invasiveHaemophilus_influenz.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214905/S0950268814000405-libre.pdf?1692757069=\u0026response-content-disposition=attachment%3B+filename%3DA_review_of_invasiveHaemophilus_influenz.pdf\u0026Expires=1732452107\u0026Signature=gEbb5lRcxtCSDwQXyJD6zl8-Sj-Yu23IFbeqDjmRtES~oQIdJyn5vko-r6gQmsILAg88Gs782Nq5ailpO6b-3-RDyKwm8Cv1S2JoJ2FyF0RB6tKWChLHIroU549Xt30wpuUjS91z1Vs5mPLXUPRp-x-UepZ7ixbvHf-lj7ZnesTE2zhD8GxACYvG6fXAWZNSOVv1kc6CHpWXSG0vt2loMenXvziSbFtMlUbZpvdWU~aGsbmarMUtAy471b3aqv8a89gLYX~Da8W4CsL3DWavIVV5wHJFRI-8zcYZhe6HeuhvJoM1Rw0VElxgWeu2wCf7~iLB2LQQaq6v4F75pNq4rw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_review_of_invasiveHaemophilus_influenzaedisease_in_the_Indigenous_populations_of_North_America","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":105214905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214905/thumbnails/1.jpg","file_name":"S0950268814000405.pdf","download_url":"https://www.academia.edu/attachments/105214905/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_review_of_invasiveHaemophilus_influenz.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214905/S0950268814000405-libre.pdf?1692757069=\u0026response-content-disposition=attachment%3B+filename%3DA_review_of_invasiveHaemophilus_influenz.pdf\u0026Expires=1732452107\u0026Signature=gEbb5lRcxtCSDwQXyJD6zl8-Sj-Yu23IFbeqDjmRtES~oQIdJyn5vko-r6gQmsILAg88Gs782Nq5ailpO6b-3-RDyKwm8Cv1S2JoJ2FyF0RB6tKWChLHIroU549Xt30wpuUjS91z1Vs5mPLXUPRp-x-UepZ7ixbvHf-lj7ZnesTE2zhD8GxACYvG6fXAWZNSOVv1kc6CHpWXSG0vt2loMenXvziSbFtMlUbZpvdWU~aGsbmarMUtAy471b3aqv8a89gLYX~Da8W4CsL3DWavIVV5wHJFRI-8zcYZhe6HeuhvJoM1Rw0VElxgWeu2wCf7~iLB2LQQaq6v4F75pNq4rw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":105214906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214906/thumbnails/1.jpg","file_name":"S0950268814000405.pdf","download_url":"https://www.academia.edu/attachments/105214906/download_file","bulk_download_file_name":"A_review_of_invasiveHaemophilus_influenz.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214906/S0950268814000405-libre.pdf?1692757071=\u0026response-content-disposition=attachment%3B+filename%3DA_review_of_invasiveHaemophilus_influenz.pdf\u0026Expires=1732452107\u0026Signature=Q2wdM9r~ucm1wxgkN2Ie85705ZOfoJTPyfbLC9yZGRaPU8PcTAtKeDedZeh0H7r5hbsQRAQCH8gaGVpd5MVQy20mxl5ZlFRQoqxDYxmw-GkWPtVOBY6QRt5lSVLJ8x6xxyFTDyo-el8l8wQ3w0QDA9siFwJotyeL8yXWAnfmhE6ae~bIgJMxcr-C4lLW3Pveh5rzQ3pzBSE6PFogpocM9D3QfW80xUuNNjlK6jCPc36wbGQTr1dpnL6ZKQx6~4z082QFC0EQ5scoQNqSc8yB4ED4kVQls0xsAPolPiNvJtlZUj5TsiJXOFbTRv72eiPmVGOfGLfppUs4emwiIJPT-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64336,"name":"Population","url":"https://www.academia.edu/Documents/in/Population"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99773,"name":"Disease","url":"https://www.academia.edu/Documents/in/Disease"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":865641,"name":"North American Indians","url":"https://www.academia.edu/Documents/in/North_American_Indians"},{"id":1218440,"name":"Indigenous","url":"https://www.academia.edu/Documents/in/Indigenous"},{"id":1533489,"name":"Haemophilus Infections Market","url":"https://www.academia.edu/Documents/in/Haemophilus_Infections_Market"},{"id":1990998,"name":"Haemophilus influenzae","url":"https://www.academia.edu/Documents/in/Haemophilus_influenzae"},{"id":2494432,"name":"Carriage","url":"https://www.academia.edu/Documents/in/Carriage"}],"urls":[{"id":33566259,"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0950268814000405"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863968"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863968/Studies_on_the_humoral_immune_response_to_a_synthetic_vaccine_against_Plasmodium_falciparum_malaria"><img alt="Research paper thumbnail of Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria" class="work-thumbnail" src="https://attachments.academia-assets.com/105214904/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863968/Studies_on_the_humoral_immune_response_to_a_synthetic_vaccine_against_Plasmodium_falciparum_malaria">Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Immunology</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">SUMMARY A synthetic vaccine against the asexual blood stages of P. falciparum, the SPF 66 synthet...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">SUMMARY A synthetic vaccine against the asexual blood stages of P. falciparum, the SPF 66 synthetic hybrid polymer, composed of peptides derived from three merozoite membrane proteins as well as one peptide from the sporozoite CS protein, has been developed by our group and tested in different protection assays in Aotus monkeys as well as in human volunteers. This study evaluates the humoral immune response induced by the SPf 66 protein vaccination in adult human volunteers from the Colombian Pacific coast as follows: determination of specific IgG antibody levels against SPf 66 by FAST-ELISA after each immunization; analysis of antibody reactivity with P. falciparum schizont lysates by immunoblots; and determination of the in vitro parasite growth inhibition. A clear boosting effect, dependent on time and dose, was observed in the antibody production kinetics. These antibodies also specifically recognize three proteins of the P. falciparum schizont lysate corresponding to the molecu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9856a7eca58c4a1d93b361565ba0806f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105214904,"asset_id":105863968,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105214904/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863968"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863968"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863968; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863968]").text(description); $(".js-view-count[data-work-id=105863968]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863968; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863968']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863968, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9856a7eca58c4a1d93b361565ba0806f" } } $('.js-work-strip[data-work-id=105863968]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863968,"title":"Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria","translated_title":"","metadata":{"abstract":"SUMMARY A synthetic vaccine against the asexual blood stages of P. falciparum, the SPF 66 synthetic hybrid polymer, composed of peptides derived from three merozoite membrane proteins as well as one peptide from the sporozoite CS protein, has been developed by our group and tested in different protection assays in Aotus monkeys as well as in human volunteers. This study evaluates the humoral immune response induced by the SPf 66 protein vaccination in adult human volunteers from the Colombian Pacific coast as follows: determination of specific IgG antibody levels against SPf 66 by FAST-ELISA after each immunization; analysis of antibody reactivity with P. falciparum schizont lysates by immunoblots; and determination of the in vitro parasite growth inhibition. A clear boosting effect, dependent on time and dose, was observed in the antibody production kinetics. These antibodies also specifically recognize three proteins of the P. falciparum schizont lysate corresponding to the molecu...","publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Clinical and Experimental Immunology"},"translated_abstract":"SUMMARY A synthetic vaccine against the asexual blood stages of P. falciparum, the SPF 66 synthetic hybrid polymer, composed of peptides derived from three merozoite membrane proteins as well as one peptide from the sporozoite CS protein, has been developed by our group and tested in different protection assays in Aotus monkeys as well as in human volunteers. This study evaluates the humoral immune response induced by the SPf 66 protein vaccination in adult human volunteers from the Colombian Pacific coast as follows: determination of specific IgG antibody levels against SPf 66 by FAST-ELISA after each immunization; analysis of antibody reactivity with P. falciparum schizont lysates by immunoblots; and determination of the in vitro parasite growth inhibition. A clear boosting effect, dependent on time and dose, was observed in the antibody production kinetics. These antibodies also specifically recognize three proteins of the P. falciparum schizont lysate corresponding to the molecu...","internal_url":"https://www.academia.edu/105863968/Studies_on_the_humoral_immune_response_to_a_synthetic_vaccine_against_Plasmodium_falciparum_malaria","translated_internal_url":"","created_at":"2023-08-22T18:42:19.120-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":105214904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214904/thumbnails/1.jpg","file_name":"j.1365-2249.1991.tb08134.x.pdf","download_url":"https://www.academia.edu/attachments/105214904/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Studies_on_the_humoral_immune_response_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214904/j.1365-2249.1991.tb08134.x-libre.pdf?1692757073=\u0026response-content-disposition=attachment%3B+filename%3DStudies_on_the_humoral_immune_response_t.pdf\u0026Expires=1732452107\u0026Signature=dVFN24St-OA8Hn9TllLeuawNCsyVVog8loG1ZtoEY29wZoEcn6p3nKoYkDlpCFW-mZXQkZlohIwGzWP9tMSY3zLgpVktad5ReE5uR-wK7Lw8mWDgBTd~VjUQHBAQDSB7Fvtvo-RgTMwkVzbXXb5BJguamo57cmI8bThfBcCTHhNmtcoiUCcytF9jU~iLWnRUjP5HJTfT3tG1ff2DmHtVYcgzrUhj58Pgm3qxAMGJoGyJh42zdcryj5ljsYurYUyLSaDdFMhyldGmuGQulTH1rk57mw31Ka8ZE072~IYELp2M~hyfYEyTe8YZDnT-7ZI3MjwLwe-zuura8K-SU5AVug__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Studies_on_the_humoral_immune_response_to_a_synthetic_vaccine_against_Plasmodium_falciparum_malaria","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":105214904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214904/thumbnails/1.jpg","file_name":"j.1365-2249.1991.tb08134.x.pdf","download_url":"https://www.academia.edu/attachments/105214904/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Studies_on_the_humoral_immune_response_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214904/j.1365-2249.1991.tb08134.x-libre.pdf?1692757073=\u0026response-content-disposition=attachment%3B+filename%3DStudies_on_the_humoral_immune_response_t.pdf\u0026Expires=1732452107\u0026Signature=dVFN24St-OA8Hn9TllLeuawNCsyVVog8loG1ZtoEY29wZoEcn6p3nKoYkDlpCFW-mZXQkZlohIwGzWP9tMSY3zLgpVktad5ReE5uR-wK7Lw8mWDgBTd~VjUQHBAQDSB7Fvtvo-RgTMwkVzbXXb5BJguamo57cmI8bThfBcCTHhNmtcoiUCcytF9jU~iLWnRUjP5HJTfT3tG1ff2DmHtVYcgzrUhj58Pgm3qxAMGJoGyJh42zdcryj5ljsYurYUyLSaDdFMhyldGmuGQulTH1rk57mw31Ka8ZE072~IYELp2M~hyfYEyTe8YZDnT-7ZI3MjwLwe-zuura8K-SU5AVug__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":105214903,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214903/thumbnails/1.jpg","file_name":"j.1365-2249.1991.tb08134.x.pdf","download_url":"https://www.academia.edu/attachments/105214903/download_file","bulk_download_file_name":"Studies_on_the_humoral_immune_response_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214903/j.1365-2249.1991.tb08134.x-libre.pdf?1692757075=\u0026response-content-disposition=attachment%3B+filename%3DStudies_on_the_humoral_immune_response_t.pdf\u0026Expires=1732452107\u0026Signature=FQxpnRwaP9wV5QiNlxDg5qJ5Ty~YCdtLwByn9YMcY1XH653K7Xzxw9lSceeqFVVU0pkq2HOWEn8Uz5DuHfNj6IZVqnjB1~Bq5769eJWXy4rQtu4NttMw7sTbn98bKA~Zjk31C-reUbg~DTcy4F4I0ZAPtvq0czMPAeTE9zWAxUMkVy5abadrRyqUt7ngJNMPtOH7porBPVrlSLk9ut5jAty7U3rR9fK5GV2LtSREbl50QkffElhVANVw3EwQP91b-djv1dHE4LFM7ZZTnzXPoew1o2Eayc9toFvODm3S6coG5KdqpHd6koky5MvpiQTGA52vEkR6IaXcak9CH~rGBQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":7823,"name":"Malaria","url":"https://www.academia.edu/Documents/in/Malaria"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":594229,"name":"Malaria Vaccine","url":"https://www.academia.edu/Documents/in/Malaria_Vaccine"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":2019324,"name":"Humoral Immunity","url":"https://www.academia.edu/Documents/in/Humoral_Immunity"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"}],"urls":[{"id":33566258,"url":"https://academic.oup.com/cei/article-pdf/84/1/122/42216107/j.1365-2249.1991.tb08134.x.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863929"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863929/8th_Canadian_Immunization_Conference_Sheraton_Centre_Hotel_Toronto_Ontario_November_30_to_December_3_2008"><img alt="Research paper thumbnail of 8th Canadian Immunization Conference Sheraton Centre Hotel, Toronto, Ontario November 30 to December 3, 2008" class="work-thumbnail" src="https://attachments.academia-assets.com/105214888/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863929/8th_Canadian_Immunization_Conference_Sheraton_Centre_Hotel_Toronto_Ontario_November_30_to_December_3_2008">8th Canadian Immunization Conference Sheraton Centre Hotel, Toronto, Ontario November 30 to December 3, 2008</a></div><div class="wp-workCard_item"><span>The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Medicale</span><span>, Sep 1, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bcfb6ceb9de53ceb54a6d4303957207b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105214888,"asset_id":105863929,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105214888/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863929"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863929"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863929; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863929]").text(description); $(".js-view-count[data-work-id=105863929]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863929; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863929']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863929, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bcfb6ceb9de53ceb54a6d4303957207b" } } $('.js-work-strip[data-work-id=105863929]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863929,"title":"8th Canadian Immunization Conference Sheraton Centre Hotel, Toronto, Ontario November 30 to December 3, 2008","translated_title":"","metadata":{"publication_date":{"day":1,"month":9,"year":2008,"errors":{}},"publication_name":"The Canadian Journal of Infectious Diseases \u0026 Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Medicale"},"translated_abstract":null,"internal_url":"https://www.academia.edu/105863929/8th_Canadian_Immunization_Conference_Sheraton_Centre_Hotel_Toronto_Ontario_November_30_to_December_3_2008","translated_internal_url":"","created_at":"2023-08-22T18:40:24.288-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":105214888,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214888/thumbnails/1.jpg","file_name":"0000542-200112000-00015.pdf","download_url":"https://www.academia.edu/attachments/105214888/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"8th_Canadian_Immunization_Conference_She.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214888/0000542-200112000-00015-libre.pdf?1692757073=\u0026response-content-disposition=attachment%3B+filename%3D8th_Canadian_Immunization_Conference_She.pdf\u0026Expires=1732452107\u0026Signature=DPY6-xMNjnjP1p-0pUEsFEJHN0sXAzP2vRSlds51WC4RIQ5IZ2baQIlqY8WzVbwo00JG1bhMHP2i5SVJKtrJA2MgDaz-4vPmJ52yWkGA0Ib2Ll65pXJFjsXCRkIRrY-9IQcw-5qXSRFvfyC3~Q--pVMtLZQd0yyg6p335AvS1TFPZbPW5fY-EUixjJ9AZwktEKeLg62UxsYjglEp4EO4T7cQSO1~T8Paajn30-VTjgWDBSC5XUNp0-Xk-l68WW8gxQUN0UOfaJxuawMxYyt3nv~Hqszy2MGTfljTvXSTCupUmxTUgPD0euBXBk4vNd-y2glB6E1rhNndsST~dJRx~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"8th_Canadian_Immunization_Conference_Sheraton_Centre_Hotel_Toronto_Ontario_November_30_to_December_3_2008","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":105214888,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214888/thumbnails/1.jpg","file_name":"0000542-200112000-00015.pdf","download_url":"https://www.academia.edu/attachments/105214888/download_file?st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"8th_Canadian_Immunization_Conference_She.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214888/0000542-200112000-00015-libre.pdf?1692757073=\u0026response-content-disposition=attachment%3B+filename%3D8th_Canadian_Immunization_Conference_She.pdf\u0026Expires=1732452107\u0026Signature=DPY6-xMNjnjP1p-0pUEsFEJHN0sXAzP2vRSlds51WC4RIQ5IZ2baQIlqY8WzVbwo00JG1bhMHP2i5SVJKtrJA2MgDaz-4vPmJ52yWkGA0Ib2Ll65pXJFjsXCRkIRrY-9IQcw-5qXSRFvfyC3~Q--pVMtLZQd0yyg6p335AvS1TFPZbPW5fY-EUixjJ9AZwktEKeLg62UxsYjglEp4EO4T7cQSO1~T8Paajn30-VTjgWDBSC5XUNp0-Xk-l68WW8gxQUN0UOfaJxuawMxYyt3nv~Hqszy2MGTfljTvXSTCupUmxTUgPD0euBXBk4vNd-y2glB6E1rhNndsST~dJRx~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":261,"name":"Geography","url":"https://www.academia.edu/Documents/in/Geography"},{"id":1011,"name":"Library Science","url":"https://www.academia.edu/Documents/in/Library_Science"},{"id":83684,"name":"Abstract","url":"https://www.academia.edu/Documents/in/Abstract"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99244291"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99244291/An_Anthropocentric_and_Enhanced_Predictive_Approach_to_Smart_City_Management"><img alt="Research paper thumbnail of An Anthropocentric and Enhanced Predictive Approach to Smart City Management" class="work-thumbnail" src="https://attachments.academia-assets.com/100384680/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99244291/An_Anthropocentric_and_Enhanced_Predictive_Approach_to_Smart_City_Management">An Anthropocentric and Enhanced Predictive Approach to Smart City Management</a></div><div class="wp-workCard_item"><span>Smart Cities</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cities are becoming increasingly complex to manage, as they increase in size and must provide hig...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cities are becoming increasingly complex to manage, as they increase in size and must provide higher living standards for their populations. New technology-based solutions must be developed towards attending this growth and ensuring that it is socially sustainable. This paper puts forward the notion that these solutions must share some properties: they should be anthropocentric, holistic, horizontal, multi-dimensional, multi-modal, and predictive. We propose an architecture in which streaming data sources that characterize the city context are used to feed a real-time graph of the city’s assets and states, as well as to train predictive models that hint into near future states of the city. This allows human decision-makers and automated services to take decisions, both for the present and for the future. To achieve this, multiple data sources about a city were gradually connected to a message broker, that enables increasingly rich decision-support. Results show that it is possible t...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7c0660c696b42d73021957097e1c6f80" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100384680,"asset_id":99244291,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100384680/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99244291"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99244291"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99244291; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99244291]").text(description); $(".js-view-count[data-work-id=99244291]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99244291; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99244291']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 99244291, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7c0660c696b42d73021957097e1c6f80" } } $('.js-work-strip[data-work-id=99244291]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":99244291,"title":"An Anthropocentric and Enhanced Predictive Approach to Smart City Management","translated_title":"","metadata":{"abstract":"Cities are becoming increasingly complex to manage, as they increase in size and must provide higher living standards for their populations. New technology-based solutions must be developed towards attending this growth and ensuring that it is socially sustainable. This paper puts forward the notion that these solutions must share some properties: they should be anthropocentric, holistic, horizontal, multi-dimensional, multi-modal, and predictive. We propose an architecture in which streaming data sources that characterize the city context are used to feed a real-time graph of the city’s assets and states, as well as to train predictive models that hint into near future states of the city. This allows human decision-makers and automated services to take decisions, both for the present and for the future. To achieve this, multiple data sources about a city were gradually connected to a message broker, that enables increasingly rich decision-support. Results show that it is possible t...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Smart Cities"},"translated_abstract":"Cities are becoming increasingly complex to manage, as they increase in size and must provide higher living standards for their populations. New technology-based solutions must be developed towards attending this growth and ensuring that it is socially sustainable. This paper puts forward the notion that these solutions must share some properties: they should be anthropocentric, holistic, horizontal, multi-dimensional, multi-modal, and predictive. We propose an architecture in which streaming data sources that characterize the city context are used to feed a real-time graph of the city’s assets and states, as well as to train predictive models that hint into near future states of the city. This allows human decision-makers and automated services to take decisions, both for the present and for the future. To achieve this, multiple data sources about a city were gradually connected to a message broker, that enables increasingly rich decision-support. Results show that it is possible t...","internal_url":"https://www.academia.edu/99244291/An_Anthropocentric_and_Enhanced_Predictive_Approach_to_Smart_City_Management","translated_internal_url":"","created_at":"2023-03-28T18:20:53.200-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":100384680,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/100384680/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/100384680/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"An_Anthropocentric_and_Enhanced_Predicti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/100384680/pdf-libre.pdf?1680055595=\u0026response-content-disposition=attachment%3B+filename%3DAn_Anthropocentric_and_Enhanced_Predicti.pdf\u0026Expires=1732452108\u0026Signature=OFD2ZjO86YZq4JSgq0Z3RPd~m~taBcMLrwqcFqcsehdlfrolf~dA6STVoSinHJ-dUbLrBL-RFL6FazFTzQA2akG6bVC1lRLJDDT4OpwAfQw4ESJToMxTK97zpDa43gAAcLWb9GpL4~Nm8Mq0Tz9UW~lHIK~Wrm7xHqz8zW-MP2KQXDgOfCpDQi5cXseRjw5fc9pd6kUR4ass1k4~hOSfVpmCaoDKjRVICPU6BRX2yDBBKba39BIJ2~3Ix26GabwyFs-9zNCZHgyvmCdFLbj2n7kxPmMSE9ZrZESpctWv3ZhFHW-sFkTH15IGQ7r-UYWJD1CjicgjX5ZfEYUrZiIc5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"An_Anthropocentric_and_Enhanced_Predictive_Approach_to_Smart_City_Management","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":100384680,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/100384680/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/100384680/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"An_Anthropocentric_and_Enhanced_Predicti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/100384680/pdf-libre.pdf?1680055595=\u0026response-content-disposition=attachment%3B+filename%3DAn_Anthropocentric_and_Enhanced_Predicti.pdf\u0026Expires=1732452108\u0026Signature=OFD2ZjO86YZq4JSgq0Z3RPd~m~taBcMLrwqcFqcsehdlfrolf~dA6STVoSinHJ-dUbLrBL-RFL6FazFTzQA2akG6bVC1lRLJDDT4OpwAfQw4ESJToMxTK97zpDa43gAAcLWb9GpL4~Nm8Mq0Tz9UW~lHIK~Wrm7xHqz8zW-MP2KQXDgOfCpDQi5cXseRjw5fc9pd6kUR4ass1k4~hOSfVpmCaoDKjRVICPU6BRX2yDBBKba39BIJ2~3Ix26GabwyFs-9zNCZHgyvmCdFLbj2n7kxPmMSE9ZrZESpctWv3ZhFHW-sFkTH15IGQ7r-UYWJD1CjicgjX5ZfEYUrZiIc5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":422,"name":"Computer Science","url":"https://www.academia.edu/Documents/in/Computer_Science"},{"id":26586,"name":"Anthropocentrism","url":"https://www.academia.edu/Documents/in/Anthropocentrism"},{"id":74871,"name":"Smart Cities","url":"https://www.academia.edu/Documents/in/Smart_Cities"},{"id":94893,"name":"Smart City","url":"https://www.academia.edu/Documents/in/Smart_City"}],"urls":[{"id":30142612,"url":"https://www.mdpi.com/2624-6511/4/4/72/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262329"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262329/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication"><img alt="Research paper thumbnail of Polio vaccine development in Canada: Contributions to global polio eradication" class="work-thumbnail" src="https://attachments.academia-assets.com/97492029/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262329/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication">Polio vaccine development in Canada: Contributions to global polio eradication</a></div><div class="wp-workCard_item"><span>Biologicals</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4e5db959a947cbbe15c5d7542226884d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97492029,"asset_id":95262329,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97492029/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262329"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262329"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262329; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262329]").text(description); $(".js-view-count[data-work-id=95262329]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262329; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262329']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262329, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4e5db959a947cbbe15c5d7542226884d" } } $('.js-work-strip[data-work-id=95262329]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262329,"title":"Polio vaccine development in Canada: Contributions to global polio eradication","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"The paper briefly describes Canada's distinctive experience in the control of polio and offers some lessons for governments and health policy leaders in other jurisdictions, particularly as they consider immunization policies for the post-polio-eradication era.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Biologicals","grobid_abstract_attachment_id":97492029},"translated_abstract":null,"internal_url":"https://www.academia.edu/95262329/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication","translated_internal_url":"","created_at":"2023-01-18T17:19:30.017-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97492029,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492029/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/97492029/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492029/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1674106542=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=LzKLfxPUlWJVleSQN8NpWD-PumOc59lFbMdVBQYAjDNcJ7WLAgUQxkgH918F1Qbhxs3dHwEBArBMoIhB6a8sH5J8kQ0KWc0V-RMJlkvRYq~lYox168kTnre~b-tef8E0WPOV6r8JZf5RxFt2XSmrenGZiwtYPOP5O6BBuUoL-iqtdL4pCogle3rs4ZpMld~Sud~A4taicA57DdmW891KOPi9NWF5p-yPD-KXhj0mfHY6uTIDjXlmWJfT8a03DNoREBnpb9aFzHghGvKze8h2cHRpdWEpBQTn1L~nTRaGscj9Xlb53IpLqxrUqttyJlfaRtdiJ~ASgc1G1EAuvbUQDg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":97492029,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492029/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/97492029/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492029/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1674106542=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=LzKLfxPUlWJVleSQN8NpWD-PumOc59lFbMdVBQYAjDNcJ7WLAgUQxkgH918F1Qbhxs3dHwEBArBMoIhB6a8sH5J8kQ0KWc0V-RMJlkvRYq~lYox168kTnre~b-tef8E0WPOV6r8JZf5RxFt2XSmrenGZiwtYPOP5O6BBuUoL-iqtdL4pCogle3rs4ZpMld~Sud~A4taicA57DdmW891KOPi9NWF5p-yPD-KXhj0mfHY6uTIDjXlmWJfT8a03DNoREBnpb9aFzHghGvKze8h2cHRpdWEpBQTn1L~nTRaGscj9Xlb53IpLqxrUqttyJlfaRtdiJ~ASgc1G1EAuvbUQDg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines"},{"id":4486,"name":"Political Science","url":"https://www.academia.edu/Documents/in/Political_Science"},{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health"},{"id":6553,"name":"History of Public Health","url":"https://www.academia.edu/Documents/in/History_of_Public_Health"},{"id":8920,"name":"History of Canada","url":"https://www.academia.edu/Documents/in/History_of_Canada"},{"id":17969,"name":"Health Policy","url":"https://www.academia.edu/Documents/in/Health_Policy"},{"id":24389,"name":"Poliomyelitis (History)","url":"https://www.academia.edu/Documents/in/Poliomyelitis_History_"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37800,"name":"Vaccine development","url":"https://www.academia.edu/Documents/in/Vaccine_development"},{"id":42737,"name":"Poliorcetics","url":"https://www.academia.edu/Documents/in/Poliorcetics"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":54114,"name":"Canada","url":"https://www.academia.edu/Documents/in/Canada"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":243003,"name":"Poliomyelitis","url":"https://www.academia.edu/Documents/in/Poliomyelitis"},{"id":650891,"name":"Biologicals","url":"https://www.academia.edu/Documents/in/Biologicals"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262328"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262328/Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Vaccine_With_Varying_Antigen_Quantities"><img alt="Research paper thumbnail of Safety and Immunogenicity of a Five-Component Acellular Pertussis Vaccine With Varying Antigen Quantities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262328/Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Vaccine_With_Varying_Antigen_Quantities">Safety and Immunogenicity of a Five-Component Acellular Pertussis Vaccine With Varying Antigen Quantities</a></div><div class="wp-workCard_item"><span>Archives of Pediatrics & Adolescent Medicine</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In reply We think that our article1 has been misunderstood. The word &quot;swelling&quot; was use...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In reply We think that our article1 has been misunderstood. The word &quot;swelling&quot; was used to describe the nodule by parents. The patient had only nodules and limited motion ofthe arms in the morning. Pain orjoint swellingwere not present either in the history or on physical ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262328"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262328"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262328; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262328]").text(description); $(".js-view-count[data-work-id=95262328]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262328; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262328']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262328, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262328]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262328,"title":"Safety and Immunogenicity of a Five-Component Acellular Pertussis Vaccine With Varying Antigen Quantities","translated_title":"","metadata":{"abstract":"In reply We think that our article1 has been misunderstood. The word \u0026quot;swelling\u0026quot; was used to describe the nodule by parents. The patient had only nodules and limited motion ofthe arms in the morning. Pain orjoint swellingwere not present either in the history or on physical ...","publisher":"American Medical Association (AMA)","publication_date":{"day":null,"month":null,"year":1994,"errors":{}},"publication_name":"Archives of Pediatrics \u0026 Adolescent Medicine"},"translated_abstract":"In reply We think that our article1 has been misunderstood. The word \u0026quot;swelling\u0026quot; was used to describe the nodule by parents. The patient had only nodules and limited motion ofthe arms in the morning. Pain orjoint swellingwere not present either in the history or on physical ...","internal_url":"https://www.academia.edu/95262328/Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Vaccine_With_Varying_Antigen_Quantities","translated_internal_url":"","created_at":"2023-01-18T17:19:29.912-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Vaccine_With_Varying_Antigen_Quantities","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27240,"name":"Prevention","url":"https://www.academia.edu/Documents/in/Prevention"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1714726,"name":"Bordetella Pertussis","url":"https://www.academia.edu/Documents/in/Bordetella_Pertussis"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262309"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262309/Multivalent_DTP_Polio_vaccines"><img alt="Research paper thumbnail of Multivalent DTP-Polio vaccines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262309/Multivalent_DTP_Polio_vaccines">Multivalent DTP-Polio vaccines</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262309"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262309"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262309; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262309]").text(description); $(".js-view-count[data-work-id=95262309]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262309; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262309']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262309, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262309]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262309,"title":"Multivalent DTP-Polio vaccines","translated_title":"","metadata":{"publication_date":{"day":14,"month":3,"year":2007,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/95262309/Multivalent_DTP_Polio_vaccines","translated_internal_url":"","created_at":"2023-01-18T17:17:53.616-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Multivalent_DTP_Polio_vaccines","translated_slug":"","page_count":null,"language":"es","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[],"urls":[{"id":28187310,"url":"http://www.freepatentsonline.com/EP1762246.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262308"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262308/Acellular_pertussis_vaccines_and_methods_of_preparing_thereof"><img alt="Research paper thumbnail of Acellular pertussis vaccines and methods of preparing thereof" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262308/Acellular_pertussis_vaccines_and_methods_of_preparing_thereof">Acellular pertussis vaccines and methods of preparing thereof</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262308"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262308"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262308; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262308]").text(description); $(".js-view-count[data-work-id=95262308]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262308; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262308']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262308, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262308]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262308,"title":"Acellular pertussis vaccines and methods of preparing thereof","translated_title":"","metadata":{"publication_date":{"day":2,"month":3,"year":1999,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/95262308/Acellular_pertussis_vaccines_and_methods_of_preparing_thereof","translated_internal_url":"","created_at":"2023-01-18T17:17:53.485-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Acellular_pertussis_vaccines_and_methods_of_preparing_thereof","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[],"urls":[{"id":28187309,"url":"http://www.freepatentsonline.com/5877298.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262307"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age"><img alt="Research paper thumbnail of Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzaeType B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age" class="work-thumbnail" src="https://attachments.academia-assets.com/97492000/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age">Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzaeType B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age</a></div><div class="wp-workCard_item"><span>Canadian Journal of Infectious Diseases and Medical Microbiology</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acell...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine,Haemophilus influenzaetype b (DTaP-IPV-Hib [Pediacel, sanofi pasteur, Canada]) were assessed and compared with that of Hib vaccine reconstituted with the five-component acellular pertussis combination vaccine (DTaP-IPV//Hib, Pentacel [sanofi pasteur, Canada]).METHODS: Infants were recruited at vaccine study centres in Montreal, Quebec; Simon Fraser Health Region, British Columbia, and southern Alberta after the protocol had been approved by the relevant institutional ethics committees. Written informed consent was obtained from the parents or guardians of all subjects. At two months of age, the infants were randomly assigned to receive one of three consecutive production lots of DTaP-IPV-Hib by intramuscular injection. Reactions to vaccinations were assessed by parental ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="59978afcb70ce1ed801ee98d88d14640" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97492000,"asset_id":95262307,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97492000/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262307"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262307"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262307; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262307]").text(description); $(".js-view-count[data-work-id=95262307]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262307; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262307']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262307, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "59978afcb70ce1ed801ee98d88d14640" } } $('.js-work-strip[data-work-id=95262307]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262307,"title":"Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzaeType B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age","translated_title":"","metadata":{"abstract":"OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine,Haemophilus influenzaetype b (DTaP-IPV-Hib [Pediacel, sanofi pasteur, Canada]) were assessed and compared with that of Hib vaccine reconstituted with the five-component acellular pertussis combination vaccine (DTaP-IPV//Hib, Pentacel [sanofi pasteur, Canada]).METHODS: Infants were recruited at vaccine study centres in Montreal, Quebec; Simon Fraser Health Region, British Columbia, and southern Alberta after the protocol had been approved by the relevant institutional ethics committees. Written informed consent was obtained from the parents or guardians of all subjects. At two months of age, the infants were randomly assigned to receive one of three consecutive production lots of DTaP-IPV-Hib by intramuscular injection. Reactions to vaccinations were assessed by parental ...","publisher":"Hindawi Limited","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Canadian Journal of Infectious Diseases and Medical Microbiology"},"translated_abstract":"OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine,Haemophilus influenzaetype b (DTaP-IPV-Hib [Pediacel, sanofi pasteur, Canada]) were assessed and compared with that of Hib vaccine reconstituted with the five-component acellular pertussis combination vaccine (DTaP-IPV//Hib, Pentacel [sanofi pasteur, Canada]).METHODS: Infants were recruited at vaccine study centres in Montreal, Quebec; Simon Fraser Health Region, British Columbia, and southern Alberta after the protocol had been approved by the relevant institutional ethics committees. Written informed consent was obtained from the parents or guardians of all subjects. At two months of age, the infants were randomly assigned to receive one of three consecutive production lots of DTaP-IPV-Hib by intramuscular injection. Reactions to vaccinations were assessed by parental ...","internal_url":"https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age","translated_internal_url":"","created_at":"2023-01-18T17:17:53.349-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97492000,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492000/thumbnails/1.jpg","file_name":"289842.pdf","download_url":"https://www.academia.edu/attachments/97492000/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Safety_and_Immunogenicity_of_a_Fully_Liq.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492000/289842-libre.pdf?1674106548=\u0026response-content-disposition=attachment%3B+filename%3DSafety_and_Immunogenicity_of_a_Fully_Liq.pdf\u0026Expires=1732452108\u0026Signature=Q2XpJPZB~Zt-mJRfgVBwMGMZZYg3iI9MsxihpkaFHFoLGaV8AvMU~h-D4itE0LRr7nII0cn-46z9J-3ClJEfhAiAFwVXrWVXpIXXz84RO42r30s9oe1oJrcpactnX333w-OW8geBKNsQHZRu0biMXgUcApccZ0ocRIB-wywxTAGJaSdlY~cFAEPKjbjvkuD~SX4NG28hD6nltQfrdcQ3tgyV564jOFqemc1m2q68QjuWACCQqSmsCizZBZMZtcktAS~Oh0NBG6bbewymA8xPRbZizM38VUZzyzxLayY2KDcfCJs0wa-rWCDpz7f1jRO~IkPnse6Fe55apS~n-6OSsQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":97492000,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492000/thumbnails/1.jpg","file_name":"289842.pdf","download_url":"https://www.academia.edu/attachments/97492000/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Safety_and_Immunogenicity_of_a_Fully_Liq.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492000/289842-libre.pdf?1674106548=\u0026response-content-disposition=attachment%3B+filename%3DSafety_and_Immunogenicity_of_a_Fully_Liq.pdf\u0026Expires=1732452108\u0026Signature=Q2XpJPZB~Zt-mJRfgVBwMGMZZYg3iI9MsxihpkaFHFoLGaV8AvMU~h-D4itE0LRr7nII0cn-46z9J-3ClJEfhAiAFwVXrWVXpIXXz84RO42r30s9oe1oJrcpactnX333w-OW8geBKNsQHZRu0biMXgUcApccZ0ocRIB-wywxTAGJaSdlY~cFAEPKjbjvkuD~SX4NG28hD6nltQfrdcQ3tgyV564jOFqemc1m2q68QjuWACCQqSmsCizZBZMZtcktAS~Oh0NBG6bbewymA8xPRbZizM38VUZzyzxLayY2KDcfCJs0wa-rWCDpz7f1jRO~IkPnse6Fe55apS~n-6OSsQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":56615,"name":"Canadian","url":"https://www.academia.edu/Documents/in/Canadian"},{"id":136892,"name":"Immunization","url":"https://www.academia.edu/Documents/in/Immunization"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":243003,"name":"Poliomyelitis","url":"https://www.academia.edu/Documents/in/Poliomyelitis"},{"id":600942,"name":"Tetanus","url":"https://www.academia.edu/Documents/in/Tetanus"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":1817270,"name":"Diphtheria","url":"https://www.academia.edu/Documents/in/Diphtheria"},{"id":2827641,"name":"ORIGINAL ARTICLE","url":"https://www.academia.edu/Documents/in/ORIGINAL_ARTICLE"}],"urls":[{"id":28187308,"url":"http://downloads.hindawi.com/journals/cjidmm/2007/289842.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262306"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262306/An_Evaluation_of_the_Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Diphtheria_and_Tetanus_Toxoid_Vaccine_DTaP_When_Combined_With_a_Haemophilus_influenzaeType_b_Tetanus_Toxoid_Conjugate_Vaccine_PRP_T_in_Taiwanese_Infants"><img alt="Research paper thumbnail of An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and Tetanus Toxoid Vaccine (DTaP) When Combined With a Haemophilus influenzaeType b-Tetanus Toxoid Conjugate Vaccine (PRP-T) in Taiwanese Infants" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262306/An_Evaluation_of_the_Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Diphtheria_and_Tetanus_Toxoid_Vaccine_DTaP_When_Combined_With_a_Haemophilus_influenzaeType_b_Tetanus_Toxoid_Conjugate_Vaccine_PRP_T_in_Taiwanese_Infants">An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and Tetanus Toxoid Vaccine (DTaP) When Combined With a Haemophilus influenzaeType b-Tetanus Toxoid Conjugate Vaccine (PRP-T) in Taiwanese Infants</a></div><div class="wp-workCard_item"><span>Pediatrics</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective. Immunologic interference particular to the Haemophilus influenzae type b (Hib) respons...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective. Immunologic interference particular to the Haemophilus influenzae type b (Hib) response has been observed with previous acellular pertussis-Hib combination vaccines. To test this hypothesis a clinical trial to assess the safety and immunogenicity of a five-component (pertussis toxoid [PT], filamentous hemagglutinin [FHA], pertactin [PRN], and fimbriae 2 and 3 [FIM]), pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP) when given simultaneously with a lyophilized Hib-tetanus toxoid conjugate vaccine (PRP-T) in infants at 2, 4, 6, and 18 months of age was conducted. The study compared two methods of administration: both vaccines combined in a single syringe and administered as a single injection, or both vaccines administered concurrently but at separate sites of injection. Methods. Healthy 2-month-old infants were enrolled at the National Taiwan University Hospital. DTaP, PRP-T, and oral poliomyelitis vaccine (OPV) were given at 2, 4, 6, and 18 months. Re...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262306"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262306"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262306; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262306]").text(description); $(".js-view-count[data-work-id=95262306]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262306; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262306']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262306, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262306]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262306,"title":"An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and Tetanus Toxoid Vaccine (DTaP) When Combined With a Haemophilus influenzaeType b-Tetanus Toxoid Conjugate Vaccine (PRP-T) in Taiwanese Infants","translated_title":"","metadata":{"abstract":"Objective. Immunologic interference particular to the Haemophilus influenzae type b (Hib) response has been observed with previous acellular pertussis-Hib combination vaccines. To test this hypothesis a clinical trial to assess the safety and immunogenicity of a five-component (pertussis toxoid [PT], filamentous hemagglutinin [FHA], pertactin [PRN], and fimbriae 2 and 3 [FIM]), pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP) when given simultaneously with a lyophilized Hib-tetanus toxoid conjugate vaccine (PRP-T) in infants at 2, 4, 6, and 18 months of age was conducted. The study compared two methods of administration: both vaccines combined in a single syringe and administered as a single injection, or both vaccines administered concurrently but at separate sites of injection. Methods. Healthy 2-month-old infants were enrolled at the National Taiwan University Hospital. DTaP, PRP-T, and oral poliomyelitis vaccine (OPV) were given at 2, 4, 6, and 18 months. Re...","publisher":"American Academy of Pediatrics (AAP)","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Pediatrics"},"translated_abstract":"Objective. Immunologic interference particular to the Haemophilus influenzae type b (Hib) response has been observed with previous acellular pertussis-Hib combination vaccines. To test this hypothesis a clinical trial to assess the safety and immunogenicity of a five-component (pertussis toxoid [PT], filamentous hemagglutinin [FHA], pertactin [PRN], and fimbriae 2 and 3 [FIM]), pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP) when given simultaneously with a lyophilized Hib-tetanus toxoid conjugate vaccine (PRP-T) in infants at 2, 4, 6, and 18 months of age was conducted. The study compared two methods of administration: both vaccines combined in a single syringe and administered as a single injection, or both vaccines administered concurrently but at separate sites of injection. Methods. Healthy 2-month-old infants were enrolled at the National Taiwan University Hospital. DTaP, PRP-T, and oral poliomyelitis vaccine (OPV) were given at 2, 4, 6, and 18 months. Re...","internal_url":"https://www.academia.edu/95262306/An_Evaluation_of_the_Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Diphtheria_and_Tetanus_Toxoid_Vaccine_DTaP_When_Combined_With_a_Haemophilus_influenzaeType_b_Tetanus_Toxoid_Conjugate_Vaccine_PRP_T_in_Taiwanese_Infants","translated_internal_url":"","created_at":"2023-01-18T17:17:53.207-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"An_Evaluation_of_the_Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Diphtheria_and_Tetanus_Toxoid_Vaccine_DTaP_When_Combined_With_a_Haemophilus_influenzaeType_b_Tetanus_Toxoid_Conjugate_Vaccine_PRP_T_in_Taiwanese_Infants","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics"},{"id":11558,"name":"Drug interactions","url":"https://www.academia.edu/Documents/in/Drug_interactions"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":94451,"name":"Taiwan","url":"https://www.academia.edu/Documents/in/Taiwan"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine"},{"id":600942,"name":"Tetanus","url":"https://www.academia.edu/Documents/in/Tetanus"},{"id":1250233,"name":"Tetanus Toxoid","url":"https://www.academia.edu/Documents/in/Tetanus_Toxoid"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":1490453,"name":"Whooping Cough","url":"https://www.academia.edu/Documents/in/Whooping_Cough"},{"id":1533489,"name":"Haemophilus Infections Market","url":"https://www.academia.edu/Documents/in/Haemophilus_Infections_Market"},{"id":1817270,"name":"Diphtheria","url":"https://www.academia.edu/Documents/in/Diphtheria"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":28187307,"url":"https://publications.aap.org/pediatrics/article-pdf/103/1/25/841205/25.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262305"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262305/COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLULAR_PERTUSSIS_INACTIVATED_POLIO_DTaP_IPV_VACCINE_USED_TO_RECONSTITUTE_LYOPHILIZED_H_INFLUENZAE_B_PRP_T_OR_LICENSED_DTwP_IPV_PRP_T_VACCINE_IN_INFANTS_743"><img alt="Research paper thumbnail of COMPARATIVE IMMUNOGENICITY OF AN ACELLULAR PERTUSSIS -INACTIVATED POLIO(DTaP-IPV) VACCINE USED TO RECONSTITUTE LYOPHILIZED H. INFLUENZAE B(PRP-T) OR LICENSED DTwP-IPV-PRP-T VACCINE IN INFANTS † 743" class="work-thumbnail" src="https://attachments.academia-assets.com/97492017/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262305/COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLULAR_PERTUSSIS_INACTIVATED_POLIO_DTaP_IPV_VACCINE_USED_TO_RECONSTITUTE_LYOPHILIZED_H_INFLUENZAE_B_PRP_T_OR_LICENSED_DTwP_IPV_PRP_T_VACCINE_IN_INFANTS_743">COMPARATIVE IMMUNOGENICITY OF AN ACELLULAR PERTUSSIS -INACTIVATED POLIO(DTaP-IPV) VACCINE USED TO RECONSTITUTE LYOPHILIZED H. INFLUENZAE B(PRP-T) OR LICENSED DTwP-IPV-PRP-T VACCINE IN INFANTS † 743</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, 1997</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8bdc5cd7a7334301cec3cd3e701c3e21" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97492017,"asset_id":95262305,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97492017/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262305"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262305"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262305; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262305]").text(description); $(".js-view-count[data-work-id=95262305]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262305; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262305']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262305, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8bdc5cd7a7334301cec3cd3e701c3e21" } } $('.js-work-strip[data-work-id=95262305]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262305,"title":"COMPARATIVE IMMUNOGENICITY OF AN ACELLULAR PERTUSSIS -INACTIVATED POLIO(DTaP-IPV) VACCINE USED TO RECONSTITUTE LYOPHILIZED H. INFLUENZAE B(PRP-T) OR LICENSED DTwP-IPV-PRP-T VACCINE IN INFANTS † 743","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Pediatric Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/95262305/COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLULAR_PERTUSSIS_INACTIVATED_POLIO_DTaP_IPV_VACCINE_USED_TO_RECONSTITUTE_LYOPHILIZED_H_INFLUENZAE_B_PRP_T_OR_LICENSED_DTwP_IPV_PRP_T_VACCINE_IN_INFANTS_743","translated_internal_url":"","created_at":"2023-01-18T17:17:53.031-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97492017,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492017/thumbnails/1.jpg","file_name":"pr1997922.pdf","download_url":"https://www.academia.edu/attachments/97492017/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLUL.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492017/pr1997922-libre.pdf?1674106542=\u0026response-content-disposition=attachment%3B+filename%3DCOMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLUL.pdf\u0026Expires=1732452108\u0026Signature=Z~3OcOuwgkZN8cri8xFfovVNrmUZ06EzcdE4UIjARcfRJynASX~tLuJBaR6FWMPzKm59tgypvF0L4bWrQeALWlb8gY00XdUuTQZCd3xS4yMF1lSE0BD4zSZW9pQfQuUUUCBmuLYUVD3MF-hLLDlw2rYd16r8PqS4dFVaYobs9oiX~uZK4e6bBKFq-Ned1B03Qb9kBYV0fAEl45i3~dCa6AVYSkooQtNtIDn5UmgrLTovBgMvrdubUpYhTaGFzpyxF2MOzHvPRUeRT3VLaBm-h-ctJO-mGyZK14rFP3M~xTk7v8iCh66tK60EcO1v-g-0zBcuf2hYHxY5M0j4ahsV-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLULAR_PERTUSSIS_INACTIVATED_POLIO_DTaP_IPV_VACCINE_USED_TO_RECONSTITUTE_LYOPHILIZED_H_INFLUENZAE_B_PRP_T_OR_LICENSED_DTwP_IPV_PRP_T_VACCINE_IN_INFANTS_743","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":97492017,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492017/thumbnails/1.jpg","file_name":"pr1997922.pdf","download_url":"https://www.academia.edu/attachments/97492017/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLUL.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492017/pr1997922-libre.pdf?1674106542=\u0026response-content-disposition=attachment%3B+filename%3DCOMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLUL.pdf\u0026Expires=1732452108\u0026Signature=Z~3OcOuwgkZN8cri8xFfovVNrmUZ06EzcdE4UIjARcfRJynASX~tLuJBaR6FWMPzKm59tgypvF0L4bWrQeALWlb8gY00XdUuTQZCd3xS4yMF1lSE0BD4zSZW9pQfQuUUUCBmuLYUVD3MF-hLLDlw2rYd16r8PqS4dFVaYobs9oiX~uZK4e6bBKFq-Ned1B03Qb9kBYV0fAEl45i3~dCa6AVYSkooQtNtIDn5UmgrLTovBgMvrdubUpYhTaGFzpyxF2MOzHvPRUeRT3VLaBm-h-ctJO-mGyZK14rFP3M~xTk7v8iCh66tK60EcO1v-g-0zBcuf2hYHxY5M0j4ahsV-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262292"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262292/Controlled_trial_of_Haemophilus_influenzae_type_B_diphtheria_toxoid_conjugate_combined_with_diphtheria_tetanus_and_pertussis_vaccines_in_18_month_old_children_including_comparison_of_arm_versus_thigh_injection"><img alt="Research paper thumbnail of Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262292/Controlled_trial_of_Haemophilus_influenzae_type_B_diphtheria_toxoid_conjugate_combined_with_diphtheria_tetanus_and_pertussis_vaccines_in_18_month_old_children_including_comparison_of_arm_versus_thigh_injection">Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 1992</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A randomized, controlled comparison was made in 175 healthy 18-month-old children given either di...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP-PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262292"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262292"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262292; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262292]").text(description); $(".js-view-count[data-work-id=95262292]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262292; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262292']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262292, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262292]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262292,"title":"Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection","translated_title":"","metadata":{"abstract":"A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP-PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1992,"errors":{}},"publication_name":"Vaccine"},"translated_abstract":"A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP-PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.","internal_url":"https://www.academia.edu/95262292/Controlled_trial_of_Haemophilus_influenzae_type_B_diphtheria_toxoid_conjugate_combined_with_diphtheria_tetanus_and_pertussis_vaccines_in_18_month_old_children_including_comparison_of_arm_versus_thigh_injection","translated_internal_url":"","created_at":"2023-01-18T17:17:27.227-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Controlled_trial_of_Haemophilus_influenzae_type_B_diphtheria_toxoid_conjugate_combined_with_diphtheria_tetanus_and_pertussis_vaccines_in_18_month_old_children_including_comparison_of_arm_versus_thigh_injection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":128538,"name":"Arm","url":"https://www.academia.edu/Documents/in/Arm"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":150847,"name":"Vaccine","url":"https://www.academia.edu/Documents/in/Vaccine"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial"},{"id":462777,"name":"Leg","url":"https://www.academia.edu/Documents/in/Leg"},{"id":600942,"name":"Tetanus","url":"https://www.academia.edu/Documents/in/Tetanus"},{"id":1817270,"name":"Diphtheria","url":"https://www.academia.edu/Documents/in/Diphtheria"},{"id":1944474,"name":"Diphtheria Toxin","url":"https://www.academia.edu/Documents/in/Diphtheria_Toxin"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87112351"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87112351/Vaccines_Acellular_Pertussis_and_Methods_for_Manufacturing"><img alt="Research paper thumbnail of Vaccines, Acellular Pertussis and Methods for Manufacturing" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87112351/Vaccines_Acellular_Pertussis_and_Methods_for_Manufacturing">Vaccines, Acellular Pertussis and Methods for Manufacturing</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87112351"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87112351"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87112351; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87112351]").text(description); $(".js-view-count[data-work-id=87112351]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87112351; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87112351']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87112351, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87112351]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87112351,"title":"Vaccines, Acellular Pertussis and Methods for Manufacturing","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1996,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/87112351/Vaccines_Acellular_Pertussis_and_Methods_for_Manufacturing","translated_internal_url":"","created_at":"2022-09-22T19:53:52.803-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Vaccines_Acellular_Pertussis_and_Methods_for_Manufacturing","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87112344"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87112344/Multivalent_DTP_Polio_Vaccines"><img alt="Research paper thumbnail of Multivalent DTP-Polio Vaccines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87112344/Multivalent_DTP_Polio_Vaccines">Multivalent DTP-Polio Vaccines</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87112344"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87112344"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87112344; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87112344]").text(description); $(".js-view-count[data-work-id=87112344]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87112344; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87112344']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87112344, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87112344]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87112344,"title":"Multivalent DTP-Polio Vaccines","translated_title":"","metadata":{"publication_date":{"day":20,"month":9,"year":2006,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/87112344/Multivalent_DTP_Polio_Vaccines","translated_internal_url":"","created_at":"2022-09-22T19:53:40.899-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Multivalent_DTP_Polio_Vaccines","translated_slug":"","page_count":null,"language":"es","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[],"urls":[{"id":24079113,"url":"http://www.freepatentsonline.com/EP0914153.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69809780"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69809780/Conquering_the_crippler_Canada_and_the_eradication_of_polio"><img alt="Research paper thumbnail of Conquering the crippler: Canada and the eradication of polio" class="work-thumbnail" src="https://attachments.academia-assets.com/79762841/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69809780/Conquering_the_crippler_Canada_and_the_eradication_of_polio">Conquering the crippler: Canada and the eradication of polio</a></div><div class="wp-workCard_item"><span>Canadian journal of public …</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d8488a8f8dcc188763a19c47818653c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":79762841,"asset_id":69809780,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/79762841/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69809780"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69809780"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69809780; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69809780]").text(description); $(".js-view-count[data-work-id=69809780]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69809780; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69809780']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69809780, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5d8488a8f8dcc188763a19c47818653c" } } $('.js-work-strip[data-work-id=69809780]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69809780,"title":"Conquering the crippler: Canada and the eradication of polio","translated_title":"","metadata":{"publisher":"cat.inist.fr","grobid_abstract":"with the advice of a multi-agency working group, embarked on a review of the literature to examine the issues and barriers related to Canadian population and public health (PPH) knowledge generation, dissemination and exchange, and uptake. The literature review was complemented by interviews with more than 30 Canadian, American, and United Kingdom organizations that are active in PPH research, especially synthesis research. Research organizations were asked about the mechanisms they use to support PPH research generation, synthesis, transfer, and exchange, as well as their impressions of the need for new Canadian organizational structures to encourage a more integrated approach to these tasks, including challenges to be addressed. This research project complements and builds on previous work of the CIHR-IPPH* (in partnership with the Canadian Institute for Health Information, Canadian Population Health Initiative (CIHI-CPHI)), which consulted PPH researchers, practitioners, and policy-makers to identify research and knowledge transfer and exchange priorities in population and public health. During these consultation sessions, a number of challenges and opportunities were raised in relation to the synthesis, exchange and transfer of the","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Canadian journal of public …","grobid_abstract_attachment_id":79762841},"translated_abstract":null,"internal_url":"https://www.academia.edu/69809780/Conquering_the_crippler_Canada_and_the_eradication_of_polio","translated_internal_url":"","created_at":"2022-01-28T10:20:27.861-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":79762841,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/79762841/thumbnails/1.jpg","file_name":"Conquering_the_crippler_Canada_and_the_e20220128-18481-6n3le3.pdf","download_url":"https://www.academia.edu/attachments/79762841/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Conquering_the_crippler_Canada_and_the_e.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/79762841/Conquering_the_crippler_Canada_and_the_e20220128-18481-6n3le3.pdf?1643394093=\u0026response-content-disposition=attachment%3B+filename%3DConquering_the_crippler_Canada_and_the_e.pdf\u0026Expires=1732452108\u0026Signature=LJTo5QBGEMD-h5TLIwLKMx5tuxrP1kTxPoXhWUm11HMkAv7aR6Aiz8-QVX7RlMAu5LCtmRlN40hwjJQwHWOUukF-85uwf6KpU0-9F696rwJTgEniADknBJQ4KCoIfwUDZbT1ySlROdVegI4XBhvZZEuuQlRCY9XEVyLQnyVQmUaY-qf3rYh~My947YCAaZ2aeYhVwV7B1NgKPll0W6q2XzRvD-mtFKSQj~VkxK-ShRfcRQVk~zhmlpZJVUPs15xGFTQUAsnf8Gpvm5WmtqbuzrOzwxxe~vavbFZeyfcGTIJTaBl0LuuYlFH9cIzgjWYNahuMIvBpveEqaGSWM3Hm6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Conquering_the_crippler_Canada_and_the_eradication_of_polio","translated_slug":"","page_count":19,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":79762841,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/79762841/thumbnails/1.jpg","file_name":"Conquering_the_crippler_Canada_and_the_e20220128-18481-6n3le3.pdf","download_url":"https://www.academia.edu/attachments/79762841/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Conquering_the_crippler_Canada_and_the_e.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/79762841/Conquering_the_crippler_Canada_and_the_e20220128-18481-6n3le3.pdf?1643394093=\u0026response-content-disposition=attachment%3B+filename%3DConquering_the_crippler_Canada_and_the_e.pdf\u0026Expires=1732452108\u0026Signature=LJTo5QBGEMD-h5TLIwLKMx5tuxrP1kTxPoXhWUm11HMkAv7aR6Aiz8-QVX7RlMAu5LCtmRlN40hwjJQwHWOUukF-85uwf6KpU0-9F696rwJTgEniADknBJQ4KCoIfwUDZbT1ySlROdVegI4XBhvZZEuuQlRCY9XEVyLQnyVQmUaY-qf3rYh~My947YCAaZ2aeYhVwV7B1NgKPll0W6q2XzRvD-mtFKSQj~VkxK-ShRfcRQVk~zhmlpZJVUPs15xGFTQUAsnf8Gpvm5WmtqbuzrOzwxxe~vavbFZeyfcGTIJTaBl0LuuYlFH9cIzgjWYNahuMIvBpveEqaGSWM3Hm6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":54114,"name":"Canada","url":"https://www.academia.edu/Documents/in/Canada"},{"id":57907,"name":"Disease Outbreaks","url":"https://www.academia.edu/Documents/in/Disease_Outbreaks"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":243003,"name":"Poliomyelitis","url":"https://www.academia.edu/Documents/in/Poliomyelitis"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":485238,"name":"Canadian Public Policy","url":"https://www.academia.edu/Documents/in/Canadian_Public_Policy"},{"id":508371,"name":"Curriculum and Pedagogy","url":"https://www.academia.edu/Documents/in/Curriculum_and_Pedagogy"},{"id":1852990,"name":"Canadian Public Health Policy","url":"https://www.academia.edu/Documents/in/Canadian_Public_Health_Policy"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62383392"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62383392/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication"><img alt="Research paper thumbnail of Polio vaccine development in Canada: Contributions to global polio eradication" class="work-thumbnail" src="https://attachments.academia-assets.com/75167119/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62383392/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication">Polio vaccine development in Canada: Contributions to global polio eradication</a></div><div class="wp-workCard_item"><span>Biologicals</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d00e215dcbabb8b9d0a2fb7610e92231" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75167119,"asset_id":62383392,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75167119/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62383392"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62383392"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62383392; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=62383392]").text(description); $(".js-view-count[data-work-id=62383392]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 62383392; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='62383392']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 62383392, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d00e215dcbabb8b9d0a2fb7610e92231" } } $('.js-work-strip[data-work-id=62383392]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":62383392,"title":"Polio vaccine development in Canada: Contributions to global polio eradication","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Biologicals"},"translated_abstract":null,"internal_url":"https://www.academia.edu/62383392/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication","translated_internal_url":"","created_at":"2021-11-25T11:25:47.191-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75167119,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75167119/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/75167119/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75167119/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1637869233=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=bGvPrnAcaVjkUbVgVoOb9mYZVWjV5rD~0AOhHpG6NM0cUPQoS4dqAfA2W-MENXG~ObwWqZJeLik9WryG2oHlRqcSYT4De8nNzwTKUy~UodgKhxblEIqLuCH52ITQxi-lnfR9V6~c2IZcFbSmJMrVN4vv1gJ5oRTwf6DVz1dFz0ONxxY3y3Z3RqM5tSWlFLDjRj6rn-eJ6p84~MkX2R7KyruNAvDnjy89fLPdpYRUSjFALRVEcR5vHl2~WncmUSXykgQfszP~mybFDg-XBDeWyHt2YPMBy4ZRdj3diEvrK5NqV~1jV2bkKP8vE2tc2SGm0y-uRP~ylcY-jA0Ho2v1-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":75167119,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75167119/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/75167119/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75167119/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1637869233=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=bGvPrnAcaVjkUbVgVoOb9mYZVWjV5rD~0AOhHpG6NM0cUPQoS4dqAfA2W-MENXG~ObwWqZJeLik9WryG2oHlRqcSYT4De8nNzwTKUy~UodgKhxblEIqLuCH52ITQxi-lnfR9V6~c2IZcFbSmJMrVN4vv1gJ5oRTwf6DVz1dFz0ONxxY3y3Z3RqM5tSWlFLDjRj6rn-eJ6p84~MkX2R7KyruNAvDnjy89fLPdpYRUSjFALRVEcR5vHl2~WncmUSXykgQfszP~mybFDg-XBDeWyHt2YPMBy4ZRdj3diEvrK5NqV~1jV2bkKP8vE2tc2SGm0y-uRP~ylcY-jA0Ho2v1-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":75167120,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75167120/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/75167120/download_file","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75167120/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1637869233=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=XVLOJkEKXmsisS3nErMKbaFGuIoJhO-W9Gw-TLlRjXiFJ9p2uRjxpeis2pYDSultgUiGv9D6wyA7qWAd8ImMTKQ-PGqgszb~DFLOFGYzU5p0PwqeQMzUBOiIuLkcdVSowQiC-DT6PSnTOx0ICxy5fTuFJ~S6k5Q69vxKed~ApGA3S5YNCx95d19wZWDM157-CGjGbVW-R4JapkodQHtjXlvINSkiKX-A-ieEb8OT9DQ46x-8bCVPmkyEzV4lt1uDJEUV~~GwAWyBl5x1CIX1Wwaj~eR~bJm0ekgpvAzhYrE7Z41KLmrSlYGsvUuirSd3LMpO2BAn~kJVVfuqSaVtMw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines"},{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health"},{"id":6553,"name":"History of Public Health","url":"https://www.academia.edu/Documents/in/History_of_Public_Health"},{"id":8920,"name":"History of Canada","url":"https://www.academia.edu/Documents/in/History_of_Canada"},{"id":17969,"name":"Health Policy","url":"https://www.academia.edu/Documents/in/Health_Policy"},{"id":24389,"name":"Poliomyelitis (History)","url":"https://www.academia.edu/Documents/in/Poliomyelitis_History_"},{"id":37800,"name":"Vaccine development","url":"https://www.academia.edu/Documents/in/Vaccine_development"},{"id":42737,"name":"Poliorcetics","url":"https://www.academia.edu/Documents/in/Poliorcetics"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":54114,"name":"Canada","url":"https://www.academia.edu/Documents/in/Canada"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":243003,"name":"Poliomyelitis","url":"https://www.academia.edu/Documents/in/Poliomyelitis"},{"id":650891,"name":"Biologicals","url":"https://www.academia.edu/Documents/in/Biologicals"}],"urls":[{"id":14483944,"url":"http://www.healthheritageresearch.com/Polio-Biologicals34-2-June2006sdarticle.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4061789" id="papers"><div class="js-work-strip profile--work_container" data-work-id="125340432"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125340432/Immunogenicity_and_safety_of_a_recombinant_adenovirus_type_5_vectored_COVID_19_vaccine_in_healthy_adults_aged_18_years_or_older_a_randomised_double_blind_placebo_controlled_phase_2_trial"><img alt="Research paper thumbnail of Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial" class="work-thumbnail" src="https://attachments.academia-assets.com/119402386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125340432/Immunogenicity_and_safety_of_a_recombinant_adenovirus_type_5_vectored_COVID_19_vaccine_in_healthy_adults_aged_18_years_or_older_a_randomised_double_blind_placebo_controlled_phase_2_trial">Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial</a></div><div class="wp-workCard_item"><span>The Lancet</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b85fd78a8e4b5673552f5e5246e5d41a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":119402386,"asset_id":125340432,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/119402386/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125340432"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="125340432"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 125340432; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125340432]").text(description); $(".js-view-count[data-work-id=125340432]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 125340432; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='125340432']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 125340432, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b85fd78a8e4b5673552f5e5246e5d41a" } } $('.js-work-strip[data-work-id=125340432]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":125340432,"title":"Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"The Lancet"},"translated_abstract":null,"internal_url":"https://www.academia.edu/125340432/Immunogenicity_and_safety_of_a_recombinant_adenovirus_type_5_vectored_COVID_19_vaccine_in_healthy_adults_aged_18_years_or_older_a_randomised_double_blind_placebo_controlled_phase_2_trial","translated_internal_url":"","created_at":"2024-11-06T16:00:34.982-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":119402386,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/119402386/thumbnails/1.jpg","file_name":"main.pdf","download_url":"https://www.academia.edu/attachments/119402386/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immunogenicity_and_safety_of_a_recombina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/119402386/main-libre.pdf?1730959458=\u0026response-content-disposition=attachment%3B+filename%3DImmunogenicity_and_safety_of_a_recombina.pdf\u0026Expires=1732452107\u0026Signature=HY7NrWd4mgGf-5CLdRGJFNT51TCK5Dsl~lUg3U9jaKZ~cmoCp3d9E-AXjYYjd-AKH4NXcXhmH27LzZfMg9BJGO2jcwlVAGJrx0E~L1v2JEQAw3xe1trWT79-0hhsOiirevC1zJZ-lFGPj~1NxXYFq2CqrH0-gm7nY6i32EaOmx4-VpaSAXijTcjq5OPEuVIk94bR8S7xYnQdWLA7mJIEQr2oQrNjvqPyW3Tbb56eIPeCiI1s3c8NallX9uo0Wxlq9A9IPQlvOZCdfwIkwOI2~UTcmcFu-DnFbRmiPlCteT9DJM2nh3v3jUBx-3Vzq3ZLlXzy6UrbHKzC5~ZJDOFgsg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Immunogenicity_and_safety_of_a_recombinant_adenovirus_type_5_vectored_COVID_19_vaccine_in_healthy_adults_aged_18_years_or_older_a_randomised_double_blind_placebo_controlled_phase_2_trial","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":119402386,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/119402386/thumbnails/1.jpg","file_name":"main.pdf","download_url":"https://www.academia.edu/attachments/119402386/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immunogenicity_and_safety_of_a_recombina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/119402386/main-libre.pdf?1730959458=\u0026response-content-disposition=attachment%3B+filename%3DImmunogenicity_and_safety_of_a_recombina.pdf\u0026Expires=1732452107\u0026Signature=HY7NrWd4mgGf-5CLdRGJFNT51TCK5Dsl~lUg3U9jaKZ~cmoCp3d9E-AXjYYjd-AKH4NXcXhmH27LzZfMg9BJGO2jcwlVAGJrx0E~L1v2JEQAw3xe1trWT79-0hhsOiirevC1zJZ-lFGPj~1NxXYFq2CqrH0-gm7nY6i32EaOmx4-VpaSAXijTcjq5OPEuVIk94bR8S7xYnQdWLA7mJIEQr2oQrNjvqPyW3Tbb56eIPeCiI1s3c8NallX9uo0Wxlq9A9IPQlvOZCdfwIkwOI2~UTcmcFu-DnFbRmiPlCteT9DJM2nh3v3jUBx-3Vzq3ZLlXzy6UrbHKzC5~ZJDOFgsg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":72938,"name":"Placebo","url":"https://www.academia.edu/Documents/in/Placebo"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":259819,"name":"Recombinant DNA","url":"https://www.academia.edu/Documents/in/Recombinant_DNA"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":2056374,"name":"Seroconversion","url":"https://www.academia.edu/Documents/in/Seroconversion"},{"id":2601211,"name":"Adverse effect","url":"https://www.academia.edu/Documents/in/Adverse_effect"},{"id":3094070,"name":"The Lancet","url":"https://www.academia.edu/Documents/in/The_Lancet"},{"id":3686510,"name":"Coronavirus Disease 2019 (COVID-19)","url":"https://www.academia.edu/Documents/in/Coronavirus_Disease_2019_COVID-19_"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":45497908,"url":"https://api.elsevier.com/content/article/PII:S0140673620316056?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110584469"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110584469/The_Pediatric_Infectious_Disease_Journal"><img alt="Research paper thumbnail of The Pediatric Infectious Disease Journal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110584469/The_Pediatric_Infectious_Disease_Journal">The Pediatric Infectious Disease Journal</a></div><div class="wp-workCard_item"><span>The Pediatric Infectious Disease Journal</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Pediatr Infect Dis J. 2014 Aug 14. [Epub ahead of print] Human Parechovirus Infection in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Pediatr Infect Dis J. 2014 Aug 14. [Epub ahead of print] Human Parechovirus Infection in Neonatal Intensive Care. Davis J1, Fairley D, Christie S, Coyle P, Tubman R, Shields MD. Author information Abstract BACKGROUND:: Approximately 5-6% of all infective episodes in NICU are of viral origin. Previous studies suggest that human parechovirus (HPeV) infection presents most commonly in term infants, as a sepsis-like syndrome in which meningoencephalitis is prominent. Our aim was to study the infection rate and associated features of HPeV. METHODS:: Blood samples were taken from NICU babies greater than 48 hours old, who were being investigated for late onset sepsis. Clinical and laboratory data were collected at the time of the suspected sepsis episode. Samples were tested using universal primers and probe directed at the 5&amp;amp;#39;-untranslated region of the HPeV genome by reverse transcriptase PCR. Results were confirmed by electrophoresis and DNA sequencing. RESULTS:: HPeV was detected in 11 of 84 samples (13%). These infants had a mean (interquartile range, IQR) gestational age of 28.9 (26.9 - 30.6) weeks and mean birth weight of 1.26 (SD = 0.72) kg. The median day of presentation was 16 (IQR: 11-27). These characteristics were similar to the infants without positive viral detection. Six infants presented with respiratory signs. One infant presented with signs of meningitis. Six of the 11 episodes of HPeV infection occurred during the winter months (December - February). No HPeV positive infants had abnormal findings on their 28-day cranial ultrasound examination. CONCLUSIONS:: We found a HPeV infection rate of 13% in infants being tested for late onset sepsis. HPeV should be considered as a possible cause of sepsis-like symptoms in preterm infants.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110584469"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110584469"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110584469; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110584469]").text(description); $(".js-view-count[data-work-id=110584469]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110584469; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110584469']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110584469, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=110584469]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110584469,"title":"The Pediatric Infectious Disease Journal","translated_title":"","metadata":{"abstract":"ABSTRACT Pediatr Infect Dis J. 2014 Aug 14. [Epub ahead of print] Human Parechovirus Infection in Neonatal Intensive Care. Davis J1, Fairley D, Christie S, Coyle P, Tubman R, Shields MD. Author information Abstract BACKGROUND:: Approximately 5-6% of all infective episodes in NICU are of viral origin. Previous studies suggest that human parechovirus (HPeV) infection presents most commonly in term infants, as a sepsis-like syndrome in which meningoencephalitis is prominent. Our aim was to study the infection rate and associated features of HPeV. METHODS:: Blood samples were taken from NICU babies greater than 48 hours old, who were being investigated for late onset sepsis. Clinical and laboratory data were collected at the time of the suspected sepsis episode. Samples were tested using universal primers and probe directed at the 5\u0026amp;amp;#39;-untranslated region of the HPeV genome by reverse transcriptase PCR. Results were confirmed by electrophoresis and DNA sequencing. RESULTS:: HPeV was detected in 11 of 84 samples (13%). These infants had a mean (interquartile range, IQR) gestational age of 28.9 (26.9 - 30.6) weeks and mean birth weight of 1.26 (SD = 0.72) kg. The median day of presentation was 16 (IQR: 11-27). These characteristics were similar to the infants without positive viral detection. Six infants presented with respiratory signs. One infant presented with signs of meningitis. Six of the 11 episodes of HPeV infection occurred during the winter months (December - February). No HPeV positive infants had abnormal findings on their 28-day cranial ultrasound examination. CONCLUSIONS:: We found a HPeV infection rate of 13% in infants being tested for late onset sepsis. HPeV should be considered as a possible cause of sepsis-like symptoms in preterm infants.","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1991,"errors":{}},"publication_name":"The Pediatric Infectious Disease Journal"},"translated_abstract":"ABSTRACT Pediatr Infect Dis J. 2014 Aug 14. [Epub ahead of print] Human Parechovirus Infection in Neonatal Intensive Care. Davis J1, Fairley D, Christie S, Coyle P, Tubman R, Shields MD. Author information Abstract BACKGROUND:: Approximately 5-6% of all infective episodes in NICU are of viral origin. Previous studies suggest that human parechovirus (HPeV) infection presents most commonly in term infants, as a sepsis-like syndrome in which meningoencephalitis is prominent. Our aim was to study the infection rate and associated features of HPeV. METHODS:: Blood samples were taken from NICU babies greater than 48 hours old, who were being investigated for late onset sepsis. Clinical and laboratory data were collected at the time of the suspected sepsis episode. Samples were tested using universal primers and probe directed at the 5\u0026amp;amp;#39;-untranslated region of the HPeV genome by reverse transcriptase PCR. Results were confirmed by electrophoresis and DNA sequencing. RESULTS:: HPeV was detected in 11 of 84 samples (13%). These infants had a mean (interquartile range, IQR) gestational age of 28.9 (26.9 - 30.6) weeks and mean birth weight of 1.26 (SD = 0.72) kg. The median day of presentation was 16 (IQR: 11-27). These characteristics were similar to the infants without positive viral detection. Six infants presented with respiratory signs. One infant presented with signs of meningitis. Six of the 11 episodes of HPeV infection occurred during the winter months (December - February). No HPeV positive infants had abnormal findings on their 28-day cranial ultrasound examination. CONCLUSIONS:: We found a HPeV infection rate of 13% in infants being tested for late onset sepsis. HPeV should be considered as a possible cause of sepsis-like symptoms in preterm infants.","internal_url":"https://www.academia.edu/110584469/The_Pediatric_Infectious_Disease_Journal","translated_internal_url":"","created_at":"2023-12-04T18:10:59.905-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Pediatric_Infectious_Disease_Journal","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":81309,"name":"Infectious Disease","url":"https://www.academia.edu/Documents/in/Infectious_Disease"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":36456990,"url":"http://journals.lww.com/00006454-199110000-00020"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863971"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863971/Acellular_pertussis_vaccines_and_methods_for_their_preparation"><img alt="Research paper thumbnail of Acellular pertussis vaccines and methods for their preparation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863971/Acellular_pertussis_vaccines_and_methods_for_their_preparation">Acellular pertussis vaccines and methods for their preparation</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863971"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863971"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863971; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863971]").text(description); $(".js-view-count[data-work-id=105863971]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863971; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863971']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863971, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105863971]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863971,"title":"Acellular pertussis vaccines and methods for their preparation","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1996,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/105863971/Acellular_pertussis_vaccines_and_methods_for_their_preparation","translated_internal_url":"","created_at":"2023-08-22T18:42:20.036-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Acellular_pertussis_vaccines_and_methods_for_their_preparation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863970"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863970/Humoral_immunity_10_years_after_booster_immunization_with_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine"><img alt="Research paper thumbnail of Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863970/Humoral_immunity_10_years_after_booster_immunization_with_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine">Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863970"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863970"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863970; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863970]").text(description); $(".js-view-count[data-work-id=105863970]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863970; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863970']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863970, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105863970]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863970,"title":"Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Vaccine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/105863970/Humoral_immunity_10_years_after_booster_immunization_with_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine","translated_internal_url":"","created_at":"2023-08-22T18:42:19.728-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Humoral_immunity_10_years_after_booster_immunization_with_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":136892,"name":"Immunization","url":"https://www.academia.edu/Documents/in/Immunization"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":150847,"name":"Vaccine","url":"https://www.academia.edu/Documents/in/Vaccine"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors"},{"id":600942,"name":"Tetanus","url":"https://www.academia.edu/Documents/in/Tetanus"},{"id":1490453,"name":"Whooping Cough","url":"https://www.academia.edu/Documents/in/Whooping_Cough"},{"id":1817270,"name":"Diphtheria","url":"https://www.academia.edu/Documents/in/Diphtheria"},{"id":2584909,"name":"Antitoxin","url":"https://www.academia.edu/Documents/in/Antitoxin"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":33566260,"url":"https://api.elsevier.com/content/article/PII:S0264410X12001788?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863969"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863969/A_review_of_invasiveHaemophilus_influenzaedisease_in_the_Indigenous_populations_of_North_America"><img alt="Research paper thumbnail of A review of invasiveHaemophilus influenzaedisease in the Indigenous populations of North America" class="work-thumbnail" src="https://attachments.academia-assets.com/105214905/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863969/A_review_of_invasiveHaemophilus_influenzaedisease_in_the_Indigenous_populations_of_North_America">A review of invasiveHaemophilus influenzaedisease in the Indigenous populations of North America</a></div><div class="wp-workCard_item"><span>Epidemiology and Infection</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">SUMMARYHistorically, the highest incidence rates of invasiveHaemophilus influenzaedisease in the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">SUMMARYHistorically, the highest incidence rates of invasiveHaemophilus influenzaedisease in the world were found in North American and Australian Indigenous children. Although immunization againstH. influenzaetype b (Hib) led to a marked decrease in invasive Hib disease in countries where it was implemented, this disease has not been eliminated and its rates in Indigenous communities remain higher than in the general North American population. In this literature review, we examined the epidemiology of invasiveH. influenzaedisease in the pre-Hib vaccine era, effect of carriage on disease epidemiology, immune response toH. influenzaeinfection and Hib vaccination in Indigenous and Caucasian children, and the changing epidemiology after Hib conjugate vaccine has been in use for more than two decades in North America. We also explored reasons behind the continued high rates of invasiveH. influenzaedisease in Indigenous populations in North America.H. influenzaetype a (Hia) has emerged a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3335b14a8a5c9338ce08c8516d6f85d9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105214905,"asset_id":105863969,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105214905/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863969"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863969"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863969; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863969]").text(description); $(".js-view-count[data-work-id=105863969]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863969; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863969']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863969, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3335b14a8a5c9338ce08c8516d6f85d9" } } $('.js-work-strip[data-work-id=105863969]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863969,"title":"A review of invasiveHaemophilus influenzaedisease in the Indigenous populations of North America","translated_title":"","metadata":{"abstract":"SUMMARYHistorically, the highest incidence rates of invasiveHaemophilus influenzaedisease in the world were found in North American and Australian Indigenous children. Although immunization againstH. influenzaetype b (Hib) led to a marked decrease in invasive Hib disease in countries where it was implemented, this disease has not been eliminated and its rates in Indigenous communities remain higher than in the general North American population. In this literature review, we examined the epidemiology of invasiveH. influenzaedisease in the pre-Hib vaccine era, effect of carriage on disease epidemiology, immune response toH. influenzaeinfection and Hib vaccination in Indigenous and Caucasian children, and the changing epidemiology after Hib conjugate vaccine has been in use for more than two decades in North America. We also explored reasons behind the continued high rates of invasiveH. influenzaedisease in Indigenous populations in North America.H. influenzaetype a (Hia) has emerged a...","publisher":"Cambridge University Press (CUP)","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Epidemiology and Infection"},"translated_abstract":"SUMMARYHistorically, the highest incidence rates of invasiveHaemophilus influenzaedisease in the world were found in North American and Australian Indigenous children. Although immunization againstH. influenzaetype b (Hib) led to a marked decrease in invasive Hib disease in countries where it was implemented, this disease has not been eliminated and its rates in Indigenous communities remain higher than in the general North American population. In this literature review, we examined the epidemiology of invasiveH. influenzaedisease in the pre-Hib vaccine era, effect of carriage on disease epidemiology, immune response toH. influenzaeinfection and Hib vaccination in Indigenous and Caucasian children, and the changing epidemiology after Hib conjugate vaccine has been in use for more than two decades in North America. We also explored reasons behind the continued high rates of invasiveH. influenzaedisease in Indigenous populations in North America.H. influenzaetype a (Hia) has emerged a...","internal_url":"https://www.academia.edu/105863969/A_review_of_invasiveHaemophilus_influenzaedisease_in_the_Indigenous_populations_of_North_America","translated_internal_url":"","created_at":"2023-08-22T18:42:19.463-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":105214905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214905/thumbnails/1.jpg","file_name":"S0950268814000405.pdf","download_url":"https://www.academia.edu/attachments/105214905/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_review_of_invasiveHaemophilus_influenz.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214905/S0950268814000405-libre.pdf?1692757069=\u0026response-content-disposition=attachment%3B+filename%3DA_review_of_invasiveHaemophilus_influenz.pdf\u0026Expires=1732452107\u0026Signature=gEbb5lRcxtCSDwQXyJD6zl8-Sj-Yu23IFbeqDjmRtES~oQIdJyn5vko-r6gQmsILAg88Gs782Nq5ailpO6b-3-RDyKwm8Cv1S2JoJ2FyF0RB6tKWChLHIroU549Xt30wpuUjS91z1Vs5mPLXUPRp-x-UepZ7ixbvHf-lj7ZnesTE2zhD8GxACYvG6fXAWZNSOVv1kc6CHpWXSG0vt2loMenXvziSbFtMlUbZpvdWU~aGsbmarMUtAy471b3aqv8a89gLYX~Da8W4CsL3DWavIVV5wHJFRI-8zcYZhe6HeuhvJoM1Rw0VElxgWeu2wCf7~iLB2LQQaq6v4F75pNq4rw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_review_of_invasiveHaemophilus_influenzaedisease_in_the_Indigenous_populations_of_North_America","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":105214905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214905/thumbnails/1.jpg","file_name":"S0950268814000405.pdf","download_url":"https://www.academia.edu/attachments/105214905/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_review_of_invasiveHaemophilus_influenz.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214905/S0950268814000405-libre.pdf?1692757069=\u0026response-content-disposition=attachment%3B+filename%3DA_review_of_invasiveHaemophilus_influenz.pdf\u0026Expires=1732452107\u0026Signature=gEbb5lRcxtCSDwQXyJD6zl8-Sj-Yu23IFbeqDjmRtES~oQIdJyn5vko-r6gQmsILAg88Gs782Nq5ailpO6b-3-RDyKwm8Cv1S2JoJ2FyF0RB6tKWChLHIroU549Xt30wpuUjS91z1Vs5mPLXUPRp-x-UepZ7ixbvHf-lj7ZnesTE2zhD8GxACYvG6fXAWZNSOVv1kc6CHpWXSG0vt2loMenXvziSbFtMlUbZpvdWU~aGsbmarMUtAy471b3aqv8a89gLYX~Da8W4CsL3DWavIVV5wHJFRI-8zcYZhe6HeuhvJoM1Rw0VElxgWeu2wCf7~iLB2LQQaq6v4F75pNq4rw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":105214906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214906/thumbnails/1.jpg","file_name":"S0950268814000405.pdf","download_url":"https://www.academia.edu/attachments/105214906/download_file","bulk_download_file_name":"A_review_of_invasiveHaemophilus_influenz.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214906/S0950268814000405-libre.pdf?1692757071=\u0026response-content-disposition=attachment%3B+filename%3DA_review_of_invasiveHaemophilus_influenz.pdf\u0026Expires=1732452107\u0026Signature=Q2wdM9r~ucm1wxgkN2Ie85705ZOfoJTPyfbLC9yZGRaPU8PcTAtKeDedZeh0H7r5hbsQRAQCH8gaGVpd5MVQy20mxl5ZlFRQoqxDYxmw-GkWPtVOBY6QRt5lSVLJ8x6xxyFTDyo-el8l8wQ3w0QDA9siFwJotyeL8yXWAnfmhE6ae~bIgJMxcr-C4lLW3Pveh5rzQ3pzBSE6PFogpocM9D3QfW80xUuNNjlK6jCPc36wbGQTr1dpnL6ZKQx6~4z082QFC0EQ5scoQNqSc8yB4ED4kVQls0xsAPolPiNvJtlZUj5TsiJXOFbTRv72eiPmVGOfGLfppUs4emwiIJPT-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64336,"name":"Population","url":"https://www.academia.edu/Documents/in/Population"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99773,"name":"Disease","url":"https://www.academia.edu/Documents/in/Disease"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":865641,"name":"North American Indians","url":"https://www.academia.edu/Documents/in/North_American_Indians"},{"id":1218440,"name":"Indigenous","url":"https://www.academia.edu/Documents/in/Indigenous"},{"id":1533489,"name":"Haemophilus Infections Market","url":"https://www.academia.edu/Documents/in/Haemophilus_Infections_Market"},{"id":1990998,"name":"Haemophilus influenzae","url":"https://www.academia.edu/Documents/in/Haemophilus_influenzae"},{"id":2494432,"name":"Carriage","url":"https://www.academia.edu/Documents/in/Carriage"}],"urls":[{"id":33566259,"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0950268814000405"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863968"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863968/Studies_on_the_humoral_immune_response_to_a_synthetic_vaccine_against_Plasmodium_falciparum_malaria"><img alt="Research paper thumbnail of Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria" class="work-thumbnail" src="https://attachments.academia-assets.com/105214904/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863968/Studies_on_the_humoral_immune_response_to_a_synthetic_vaccine_against_Plasmodium_falciparum_malaria">Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Immunology</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">SUMMARY A synthetic vaccine against the asexual blood stages of P. falciparum, the SPF 66 synthet...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">SUMMARY A synthetic vaccine against the asexual blood stages of P. falciparum, the SPF 66 synthetic hybrid polymer, composed of peptides derived from three merozoite membrane proteins as well as one peptide from the sporozoite CS protein, has been developed by our group and tested in different protection assays in Aotus monkeys as well as in human volunteers. This study evaluates the humoral immune response induced by the SPf 66 protein vaccination in adult human volunteers from the Colombian Pacific coast as follows: determination of specific IgG antibody levels against SPf 66 by FAST-ELISA after each immunization; analysis of antibody reactivity with P. falciparum schizont lysates by immunoblots; and determination of the in vitro parasite growth inhibition. A clear boosting effect, dependent on time and dose, was observed in the antibody production kinetics. These antibodies also specifically recognize three proteins of the P. falciparum schizont lysate corresponding to the molecu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9856a7eca58c4a1d93b361565ba0806f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105214904,"asset_id":105863968,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105214904/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863968"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863968"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863968; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863968]").text(description); $(".js-view-count[data-work-id=105863968]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863968; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863968']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863968, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9856a7eca58c4a1d93b361565ba0806f" } } $('.js-work-strip[data-work-id=105863968]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863968,"title":"Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria","translated_title":"","metadata":{"abstract":"SUMMARY A synthetic vaccine against the asexual blood stages of P. falciparum, the SPF 66 synthetic hybrid polymer, composed of peptides derived from three merozoite membrane proteins as well as one peptide from the sporozoite CS protein, has been developed by our group and tested in different protection assays in Aotus monkeys as well as in human volunteers. This study evaluates the humoral immune response induced by the SPf 66 protein vaccination in adult human volunteers from the Colombian Pacific coast as follows: determination of specific IgG antibody levels against SPf 66 by FAST-ELISA after each immunization; analysis of antibody reactivity with P. falciparum schizont lysates by immunoblots; and determination of the in vitro parasite growth inhibition. A clear boosting effect, dependent on time and dose, was observed in the antibody production kinetics. These antibodies also specifically recognize three proteins of the P. falciparum schizont lysate corresponding to the molecu...","publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Clinical and Experimental Immunology"},"translated_abstract":"SUMMARY A synthetic vaccine against the asexual blood stages of P. falciparum, the SPF 66 synthetic hybrid polymer, composed of peptides derived from three merozoite membrane proteins as well as one peptide from the sporozoite CS protein, has been developed by our group and tested in different protection assays in Aotus monkeys as well as in human volunteers. This study evaluates the humoral immune response induced by the SPf 66 protein vaccination in adult human volunteers from the Colombian Pacific coast as follows: determination of specific IgG antibody levels against SPf 66 by FAST-ELISA after each immunization; analysis of antibody reactivity with P. falciparum schizont lysates by immunoblots; and determination of the in vitro parasite growth inhibition. A clear boosting effect, dependent on time and dose, was observed in the antibody production kinetics. These antibodies also specifically recognize three proteins of the P. falciparum schizont lysate corresponding to the molecu...","internal_url":"https://www.academia.edu/105863968/Studies_on_the_humoral_immune_response_to_a_synthetic_vaccine_against_Plasmodium_falciparum_malaria","translated_internal_url":"","created_at":"2023-08-22T18:42:19.120-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":105214904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214904/thumbnails/1.jpg","file_name":"j.1365-2249.1991.tb08134.x.pdf","download_url":"https://www.academia.edu/attachments/105214904/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Studies_on_the_humoral_immune_response_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214904/j.1365-2249.1991.tb08134.x-libre.pdf?1692757073=\u0026response-content-disposition=attachment%3B+filename%3DStudies_on_the_humoral_immune_response_t.pdf\u0026Expires=1732452107\u0026Signature=dVFN24St-OA8Hn9TllLeuawNCsyVVog8loG1ZtoEY29wZoEcn6p3nKoYkDlpCFW-mZXQkZlohIwGzWP9tMSY3zLgpVktad5ReE5uR-wK7Lw8mWDgBTd~VjUQHBAQDSB7Fvtvo-RgTMwkVzbXXb5BJguamo57cmI8bThfBcCTHhNmtcoiUCcytF9jU~iLWnRUjP5HJTfT3tG1ff2DmHtVYcgzrUhj58Pgm3qxAMGJoGyJh42zdcryj5ljsYurYUyLSaDdFMhyldGmuGQulTH1rk57mw31Ka8ZE072~IYELp2M~hyfYEyTe8YZDnT-7ZI3MjwLwe-zuura8K-SU5AVug__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Studies_on_the_humoral_immune_response_to_a_synthetic_vaccine_against_Plasmodium_falciparum_malaria","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":105214904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214904/thumbnails/1.jpg","file_name":"j.1365-2249.1991.tb08134.x.pdf","download_url":"https://www.academia.edu/attachments/105214904/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Studies_on_the_humoral_immune_response_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214904/j.1365-2249.1991.tb08134.x-libre.pdf?1692757073=\u0026response-content-disposition=attachment%3B+filename%3DStudies_on_the_humoral_immune_response_t.pdf\u0026Expires=1732452107\u0026Signature=dVFN24St-OA8Hn9TllLeuawNCsyVVog8loG1ZtoEY29wZoEcn6p3nKoYkDlpCFW-mZXQkZlohIwGzWP9tMSY3zLgpVktad5ReE5uR-wK7Lw8mWDgBTd~VjUQHBAQDSB7Fvtvo-RgTMwkVzbXXb5BJguamo57cmI8bThfBcCTHhNmtcoiUCcytF9jU~iLWnRUjP5HJTfT3tG1ff2DmHtVYcgzrUhj58Pgm3qxAMGJoGyJh42zdcryj5ljsYurYUyLSaDdFMhyldGmuGQulTH1rk57mw31Ka8ZE072~IYELp2M~hyfYEyTe8YZDnT-7ZI3MjwLwe-zuura8K-SU5AVug__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":105214903,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214903/thumbnails/1.jpg","file_name":"j.1365-2249.1991.tb08134.x.pdf","download_url":"https://www.academia.edu/attachments/105214903/download_file","bulk_download_file_name":"Studies_on_the_humoral_immune_response_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214903/j.1365-2249.1991.tb08134.x-libre.pdf?1692757075=\u0026response-content-disposition=attachment%3B+filename%3DStudies_on_the_humoral_immune_response_t.pdf\u0026Expires=1732452107\u0026Signature=FQxpnRwaP9wV5QiNlxDg5qJ5Ty~YCdtLwByn9YMcY1XH653K7Xzxw9lSceeqFVVU0pkq2HOWEn8Uz5DuHfNj6IZVqnjB1~Bq5769eJWXy4rQtu4NttMw7sTbn98bKA~Zjk31C-reUbg~DTcy4F4I0ZAPtvq0czMPAeTE9zWAxUMkVy5abadrRyqUt7ngJNMPtOH7porBPVrlSLk9ut5jAty7U3rR9fK5GV2LtSREbl50QkffElhVANVw3EwQP91b-djv1dHE4LFM7ZZTnzXPoew1o2Eayc9toFvODm3S6coG5KdqpHd6koky5MvpiQTGA52vEkR6IaXcak9CH~rGBQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":7823,"name":"Malaria","url":"https://www.academia.edu/Documents/in/Malaria"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":594229,"name":"Malaria Vaccine","url":"https://www.academia.edu/Documents/in/Malaria_Vaccine"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":2019324,"name":"Humoral Immunity","url":"https://www.academia.edu/Documents/in/Humoral_Immunity"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"}],"urls":[{"id":33566258,"url":"https://academic.oup.com/cei/article-pdf/84/1/122/42216107/j.1365-2249.1991.tb08134.x.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105863929"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105863929/8th_Canadian_Immunization_Conference_Sheraton_Centre_Hotel_Toronto_Ontario_November_30_to_December_3_2008"><img alt="Research paper thumbnail of 8th Canadian Immunization Conference Sheraton Centre Hotel, Toronto, Ontario November 30 to December 3, 2008" class="work-thumbnail" src="https://attachments.academia-assets.com/105214888/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105863929/8th_Canadian_Immunization_Conference_Sheraton_Centre_Hotel_Toronto_Ontario_November_30_to_December_3_2008">8th Canadian Immunization Conference Sheraton Centre Hotel, Toronto, Ontario November 30 to December 3, 2008</a></div><div class="wp-workCard_item"><span>The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Medicale</span><span>, Sep 1, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bcfb6ceb9de53ceb54a6d4303957207b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105214888,"asset_id":105863929,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105214888/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105863929"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105863929"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105863929; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105863929]").text(description); $(".js-view-count[data-work-id=105863929]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105863929; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105863929']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105863929, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bcfb6ceb9de53ceb54a6d4303957207b" } } $('.js-work-strip[data-work-id=105863929]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105863929,"title":"8th Canadian Immunization Conference Sheraton Centre Hotel, Toronto, Ontario November 30 to December 3, 2008","translated_title":"","metadata":{"publication_date":{"day":1,"month":9,"year":2008,"errors":{}},"publication_name":"The Canadian Journal of Infectious Diseases \u0026 Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Medicale"},"translated_abstract":null,"internal_url":"https://www.academia.edu/105863929/8th_Canadian_Immunization_Conference_Sheraton_Centre_Hotel_Toronto_Ontario_November_30_to_December_3_2008","translated_internal_url":"","created_at":"2023-08-22T18:40:24.288-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":105214888,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214888/thumbnails/1.jpg","file_name":"0000542-200112000-00015.pdf","download_url":"https://www.academia.edu/attachments/105214888/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"8th_Canadian_Immunization_Conference_She.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214888/0000542-200112000-00015-libre.pdf?1692757073=\u0026response-content-disposition=attachment%3B+filename%3D8th_Canadian_Immunization_Conference_She.pdf\u0026Expires=1732452107\u0026Signature=DPY6-xMNjnjP1p-0pUEsFEJHN0sXAzP2vRSlds51WC4RIQ5IZ2baQIlqY8WzVbwo00JG1bhMHP2i5SVJKtrJA2MgDaz-4vPmJ52yWkGA0Ib2Ll65pXJFjsXCRkIRrY-9IQcw-5qXSRFvfyC3~Q--pVMtLZQd0yyg6p335AvS1TFPZbPW5fY-EUixjJ9AZwktEKeLg62UxsYjglEp4EO4T7cQSO1~T8Paajn30-VTjgWDBSC5XUNp0-Xk-l68WW8gxQUN0UOfaJxuawMxYyt3nv~Hqszy2MGTfljTvXSTCupUmxTUgPD0euBXBk4vNd-y2glB6E1rhNndsST~dJRx~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"8th_Canadian_Immunization_Conference_Sheraton_Centre_Hotel_Toronto_Ontario_November_30_to_December_3_2008","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":105214888,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105214888/thumbnails/1.jpg","file_name":"0000542-200112000-00015.pdf","download_url":"https://www.academia.edu/attachments/105214888/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"8th_Canadian_Immunization_Conference_She.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105214888/0000542-200112000-00015-libre.pdf?1692757073=\u0026response-content-disposition=attachment%3B+filename%3D8th_Canadian_Immunization_Conference_She.pdf\u0026Expires=1732452107\u0026Signature=DPY6-xMNjnjP1p-0pUEsFEJHN0sXAzP2vRSlds51WC4RIQ5IZ2baQIlqY8WzVbwo00JG1bhMHP2i5SVJKtrJA2MgDaz-4vPmJ52yWkGA0Ib2Ll65pXJFjsXCRkIRrY-9IQcw-5qXSRFvfyC3~Q--pVMtLZQd0yyg6p335AvS1TFPZbPW5fY-EUixjJ9AZwktEKeLg62UxsYjglEp4EO4T7cQSO1~T8Paajn30-VTjgWDBSC5XUNp0-Xk-l68WW8gxQUN0UOfaJxuawMxYyt3nv~Hqszy2MGTfljTvXSTCupUmxTUgPD0euBXBk4vNd-y2glB6E1rhNndsST~dJRx~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":261,"name":"Geography","url":"https://www.academia.edu/Documents/in/Geography"},{"id":1011,"name":"Library Science","url":"https://www.academia.edu/Documents/in/Library_Science"},{"id":83684,"name":"Abstract","url":"https://www.academia.edu/Documents/in/Abstract"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99244291"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99244291/An_Anthropocentric_and_Enhanced_Predictive_Approach_to_Smart_City_Management"><img alt="Research paper thumbnail of An Anthropocentric and Enhanced Predictive Approach to Smart City Management" class="work-thumbnail" src="https://attachments.academia-assets.com/100384680/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99244291/An_Anthropocentric_and_Enhanced_Predictive_Approach_to_Smart_City_Management">An Anthropocentric and Enhanced Predictive Approach to Smart City Management</a></div><div class="wp-workCard_item"><span>Smart Cities</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cities are becoming increasingly complex to manage, as they increase in size and must provide hig...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cities are becoming increasingly complex to manage, as they increase in size and must provide higher living standards for their populations. New technology-based solutions must be developed towards attending this growth and ensuring that it is socially sustainable. This paper puts forward the notion that these solutions must share some properties: they should be anthropocentric, holistic, horizontal, multi-dimensional, multi-modal, and predictive. We propose an architecture in which streaming data sources that characterize the city context are used to feed a real-time graph of the city’s assets and states, as well as to train predictive models that hint into near future states of the city. This allows human decision-makers and automated services to take decisions, both for the present and for the future. To achieve this, multiple data sources about a city were gradually connected to a message broker, that enables increasingly rich decision-support. Results show that it is possible t...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7c0660c696b42d73021957097e1c6f80" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100384680,"asset_id":99244291,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100384680/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99244291"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99244291"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99244291; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99244291]").text(description); $(".js-view-count[data-work-id=99244291]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99244291; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99244291']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 99244291, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7c0660c696b42d73021957097e1c6f80" } } $('.js-work-strip[data-work-id=99244291]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":99244291,"title":"An Anthropocentric and Enhanced Predictive Approach to Smart City Management","translated_title":"","metadata":{"abstract":"Cities are becoming increasingly complex to manage, as they increase in size and must provide higher living standards for their populations. New technology-based solutions must be developed towards attending this growth and ensuring that it is socially sustainable. This paper puts forward the notion that these solutions must share some properties: they should be anthropocentric, holistic, horizontal, multi-dimensional, multi-modal, and predictive. We propose an architecture in which streaming data sources that characterize the city context are used to feed a real-time graph of the city’s assets and states, as well as to train predictive models that hint into near future states of the city. This allows human decision-makers and automated services to take decisions, both for the present and for the future. To achieve this, multiple data sources about a city were gradually connected to a message broker, that enables increasingly rich decision-support. Results show that it is possible t...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Smart Cities"},"translated_abstract":"Cities are becoming increasingly complex to manage, as they increase in size and must provide higher living standards for their populations. New technology-based solutions must be developed towards attending this growth and ensuring that it is socially sustainable. This paper puts forward the notion that these solutions must share some properties: they should be anthropocentric, holistic, horizontal, multi-dimensional, multi-modal, and predictive. We propose an architecture in which streaming data sources that characterize the city context are used to feed a real-time graph of the city’s assets and states, as well as to train predictive models that hint into near future states of the city. This allows human decision-makers and automated services to take decisions, both for the present and for the future. To achieve this, multiple data sources about a city were gradually connected to a message broker, that enables increasingly rich decision-support. Results show that it is possible t...","internal_url":"https://www.academia.edu/99244291/An_Anthropocentric_and_Enhanced_Predictive_Approach_to_Smart_City_Management","translated_internal_url":"","created_at":"2023-03-28T18:20:53.200-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":100384680,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/100384680/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/100384680/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"An_Anthropocentric_and_Enhanced_Predicti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/100384680/pdf-libre.pdf?1680055595=\u0026response-content-disposition=attachment%3B+filename%3DAn_Anthropocentric_and_Enhanced_Predicti.pdf\u0026Expires=1732452108\u0026Signature=OFD2ZjO86YZq4JSgq0Z3RPd~m~taBcMLrwqcFqcsehdlfrolf~dA6STVoSinHJ-dUbLrBL-RFL6FazFTzQA2akG6bVC1lRLJDDT4OpwAfQw4ESJToMxTK97zpDa43gAAcLWb9GpL4~Nm8Mq0Tz9UW~lHIK~Wrm7xHqz8zW-MP2KQXDgOfCpDQi5cXseRjw5fc9pd6kUR4ass1k4~hOSfVpmCaoDKjRVICPU6BRX2yDBBKba39BIJ2~3Ix26GabwyFs-9zNCZHgyvmCdFLbj2n7kxPmMSE9ZrZESpctWv3ZhFHW-sFkTH15IGQ7r-UYWJD1CjicgjX5ZfEYUrZiIc5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"An_Anthropocentric_and_Enhanced_Predictive_Approach_to_Smart_City_Management","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":100384680,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/100384680/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/100384680/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"An_Anthropocentric_and_Enhanced_Predicti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/100384680/pdf-libre.pdf?1680055595=\u0026response-content-disposition=attachment%3B+filename%3DAn_Anthropocentric_and_Enhanced_Predicti.pdf\u0026Expires=1732452108\u0026Signature=OFD2ZjO86YZq4JSgq0Z3RPd~m~taBcMLrwqcFqcsehdlfrolf~dA6STVoSinHJ-dUbLrBL-RFL6FazFTzQA2akG6bVC1lRLJDDT4OpwAfQw4ESJToMxTK97zpDa43gAAcLWb9GpL4~Nm8Mq0Tz9UW~lHIK~Wrm7xHqz8zW-MP2KQXDgOfCpDQi5cXseRjw5fc9pd6kUR4ass1k4~hOSfVpmCaoDKjRVICPU6BRX2yDBBKba39BIJ2~3Ix26GabwyFs-9zNCZHgyvmCdFLbj2n7kxPmMSE9ZrZESpctWv3ZhFHW-sFkTH15IGQ7r-UYWJD1CjicgjX5ZfEYUrZiIc5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":422,"name":"Computer Science","url":"https://www.academia.edu/Documents/in/Computer_Science"},{"id":26586,"name":"Anthropocentrism","url":"https://www.academia.edu/Documents/in/Anthropocentrism"},{"id":74871,"name":"Smart Cities","url":"https://www.academia.edu/Documents/in/Smart_Cities"},{"id":94893,"name":"Smart City","url":"https://www.academia.edu/Documents/in/Smart_City"}],"urls":[{"id":30142612,"url":"https://www.mdpi.com/2624-6511/4/4/72/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262329"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262329/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication"><img alt="Research paper thumbnail of Polio vaccine development in Canada: Contributions to global polio eradication" class="work-thumbnail" src="https://attachments.academia-assets.com/97492029/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262329/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication">Polio vaccine development in Canada: Contributions to global polio eradication</a></div><div class="wp-workCard_item"><span>Biologicals</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4e5db959a947cbbe15c5d7542226884d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97492029,"asset_id":95262329,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97492029/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262329"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262329"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262329; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262329]").text(description); $(".js-view-count[data-work-id=95262329]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262329; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262329']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262329, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4e5db959a947cbbe15c5d7542226884d" } } $('.js-work-strip[data-work-id=95262329]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262329,"title":"Polio vaccine development in Canada: Contributions to global polio eradication","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"The paper briefly describes Canada's distinctive experience in the control of polio and offers some lessons for governments and health policy leaders in other jurisdictions, particularly as they consider immunization policies for the post-polio-eradication era.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Biologicals","grobid_abstract_attachment_id":97492029},"translated_abstract":null,"internal_url":"https://www.academia.edu/95262329/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication","translated_internal_url":"","created_at":"2023-01-18T17:19:30.017-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97492029,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492029/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/97492029/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492029/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1674106542=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=LzKLfxPUlWJVleSQN8NpWD-PumOc59lFbMdVBQYAjDNcJ7WLAgUQxkgH918F1Qbhxs3dHwEBArBMoIhB6a8sH5J8kQ0KWc0V-RMJlkvRYq~lYox168kTnre~b-tef8E0WPOV6r8JZf5RxFt2XSmrenGZiwtYPOP5O6BBuUoL-iqtdL4pCogle3rs4ZpMld~Sud~A4taicA57DdmW891KOPi9NWF5p-yPD-KXhj0mfHY6uTIDjXlmWJfT8a03DNoREBnpb9aFzHghGvKze8h2cHRpdWEpBQTn1L~nTRaGscj9Xlb53IpLqxrUqttyJlfaRtdiJ~ASgc1G1EAuvbUQDg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":97492029,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492029/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/97492029/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492029/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1674106542=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=LzKLfxPUlWJVleSQN8NpWD-PumOc59lFbMdVBQYAjDNcJ7WLAgUQxkgH918F1Qbhxs3dHwEBArBMoIhB6a8sH5J8kQ0KWc0V-RMJlkvRYq~lYox168kTnre~b-tef8E0WPOV6r8JZf5RxFt2XSmrenGZiwtYPOP5O6BBuUoL-iqtdL4pCogle3rs4ZpMld~Sud~A4taicA57DdmW891KOPi9NWF5p-yPD-KXhj0mfHY6uTIDjXlmWJfT8a03DNoREBnpb9aFzHghGvKze8h2cHRpdWEpBQTn1L~nTRaGscj9Xlb53IpLqxrUqttyJlfaRtdiJ~ASgc1G1EAuvbUQDg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines"},{"id":4486,"name":"Political Science","url":"https://www.academia.edu/Documents/in/Political_Science"},{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health"},{"id":6553,"name":"History of Public Health","url":"https://www.academia.edu/Documents/in/History_of_Public_Health"},{"id":8920,"name":"History of Canada","url":"https://www.academia.edu/Documents/in/History_of_Canada"},{"id":17969,"name":"Health Policy","url":"https://www.academia.edu/Documents/in/Health_Policy"},{"id":24389,"name":"Poliomyelitis (History)","url":"https://www.academia.edu/Documents/in/Poliomyelitis_History_"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37800,"name":"Vaccine development","url":"https://www.academia.edu/Documents/in/Vaccine_development"},{"id":42737,"name":"Poliorcetics","url":"https://www.academia.edu/Documents/in/Poliorcetics"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":54114,"name":"Canada","url":"https://www.academia.edu/Documents/in/Canada"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":243003,"name":"Poliomyelitis","url":"https://www.academia.edu/Documents/in/Poliomyelitis"},{"id":650891,"name":"Biologicals","url":"https://www.academia.edu/Documents/in/Biologicals"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262328"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262328/Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Vaccine_With_Varying_Antigen_Quantities"><img alt="Research paper thumbnail of Safety and Immunogenicity of a Five-Component Acellular Pertussis Vaccine With Varying Antigen Quantities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262328/Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Vaccine_With_Varying_Antigen_Quantities">Safety and Immunogenicity of a Five-Component Acellular Pertussis Vaccine With Varying Antigen Quantities</a></div><div class="wp-workCard_item"><span>Archives of Pediatrics & Adolescent Medicine</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In reply We think that our article1 has been misunderstood. The word &quot;swelling&quot; was use...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In reply We think that our article1 has been misunderstood. The word &quot;swelling&quot; was used to describe the nodule by parents. The patient had only nodules and limited motion ofthe arms in the morning. Pain orjoint swellingwere not present either in the history or on physical ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262328"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262328"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262328; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262328]").text(description); $(".js-view-count[data-work-id=95262328]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262328; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262328']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262328, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262328]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262328,"title":"Safety and Immunogenicity of a Five-Component Acellular Pertussis Vaccine With Varying Antigen Quantities","translated_title":"","metadata":{"abstract":"In reply We think that our article1 has been misunderstood. The word \u0026quot;swelling\u0026quot; was used to describe the nodule by parents. The patient had only nodules and limited motion ofthe arms in the morning. Pain orjoint swellingwere not present either in the history or on physical ...","publisher":"American Medical Association (AMA)","publication_date":{"day":null,"month":null,"year":1994,"errors":{}},"publication_name":"Archives of Pediatrics \u0026 Adolescent Medicine"},"translated_abstract":"In reply We think that our article1 has been misunderstood. The word \u0026quot;swelling\u0026quot; was used to describe the nodule by parents. The patient had only nodules and limited motion ofthe arms in the morning. Pain orjoint swellingwere not present either in the history or on physical ...","internal_url":"https://www.academia.edu/95262328/Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Vaccine_With_Varying_Antigen_Quantities","translated_internal_url":"","created_at":"2023-01-18T17:19:29.912-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Vaccine_With_Varying_Antigen_Quantities","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27240,"name":"Prevention","url":"https://www.academia.edu/Documents/in/Prevention"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1714726,"name":"Bordetella Pertussis","url":"https://www.academia.edu/Documents/in/Bordetella_Pertussis"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262309"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262309/Multivalent_DTP_Polio_vaccines"><img alt="Research paper thumbnail of Multivalent DTP-Polio vaccines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262309/Multivalent_DTP_Polio_vaccines">Multivalent DTP-Polio vaccines</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262309"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262309"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262309; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262309]").text(description); $(".js-view-count[data-work-id=95262309]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262309; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262309']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262309, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262309]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262309,"title":"Multivalent DTP-Polio vaccines","translated_title":"","metadata":{"publication_date":{"day":14,"month":3,"year":2007,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/95262309/Multivalent_DTP_Polio_vaccines","translated_internal_url":"","created_at":"2023-01-18T17:17:53.616-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Multivalent_DTP_Polio_vaccines","translated_slug":"","page_count":null,"language":"es","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[],"urls":[{"id":28187310,"url":"http://www.freepatentsonline.com/EP1762246.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262308"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262308/Acellular_pertussis_vaccines_and_methods_of_preparing_thereof"><img alt="Research paper thumbnail of Acellular pertussis vaccines and methods of preparing thereof" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262308/Acellular_pertussis_vaccines_and_methods_of_preparing_thereof">Acellular pertussis vaccines and methods of preparing thereof</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262308"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262308"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262308; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262308]").text(description); $(".js-view-count[data-work-id=95262308]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262308; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262308']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262308, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262308]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262308,"title":"Acellular pertussis vaccines and methods of preparing thereof","translated_title":"","metadata":{"publication_date":{"day":2,"month":3,"year":1999,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/95262308/Acellular_pertussis_vaccines_and_methods_of_preparing_thereof","translated_internal_url":"","created_at":"2023-01-18T17:17:53.485-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Acellular_pertussis_vaccines_and_methods_of_preparing_thereof","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[],"urls":[{"id":28187309,"url":"http://www.freepatentsonline.com/5877298.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262307"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age"><img alt="Research paper thumbnail of Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzaeType B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age" class="work-thumbnail" src="https://attachments.academia-assets.com/97492000/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age">Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzaeType B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age</a></div><div class="wp-workCard_item"><span>Canadian Journal of Infectious Diseases and Medical Microbiology</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acell...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine,Haemophilus influenzaetype b (DTaP-IPV-Hib [Pediacel, sanofi pasteur, Canada]) were assessed and compared with that of Hib vaccine reconstituted with the five-component acellular pertussis combination vaccine (DTaP-IPV//Hib, Pentacel [sanofi pasteur, Canada]).METHODS: Infants were recruited at vaccine study centres in Montreal, Quebec; Simon Fraser Health Region, British Columbia, and southern Alberta after the protocol had been approved by the relevant institutional ethics committees. Written informed consent was obtained from the parents or guardians of all subjects. At two months of age, the infants were randomly assigned to receive one of three consecutive production lots of DTaP-IPV-Hib by intramuscular injection. Reactions to vaccinations were assessed by parental ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="59978afcb70ce1ed801ee98d88d14640" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97492000,"asset_id":95262307,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97492000/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262307"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262307"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262307; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262307]").text(description); $(".js-view-count[data-work-id=95262307]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262307; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262307']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262307, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "59978afcb70ce1ed801ee98d88d14640" } } $('.js-work-strip[data-work-id=95262307]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262307,"title":"Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzaeType B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age","translated_title":"","metadata":{"abstract":"OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine,Haemophilus influenzaetype b (DTaP-IPV-Hib [Pediacel, sanofi pasteur, Canada]) were assessed and compared with that of Hib vaccine reconstituted with the five-component acellular pertussis combination vaccine (DTaP-IPV//Hib, Pentacel [sanofi pasteur, Canada]).METHODS: Infants were recruited at vaccine study centres in Montreal, Quebec; Simon Fraser Health Region, British Columbia, and southern Alberta after the protocol had been approved by the relevant institutional ethics committees. Written informed consent was obtained from the parents or guardians of all subjects. At two months of age, the infants were randomly assigned to receive one of three consecutive production lots of DTaP-IPV-Hib by intramuscular injection. Reactions to vaccinations were assessed by parental ...","publisher":"Hindawi Limited","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Canadian Journal of Infectious Diseases and Medical Microbiology"},"translated_abstract":"OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine,Haemophilus influenzaetype b (DTaP-IPV-Hib [Pediacel, sanofi pasteur, Canada]) were assessed and compared with that of Hib vaccine reconstituted with the five-component acellular pertussis combination vaccine (DTaP-IPV//Hib, Pentacel [sanofi pasteur, Canada]).METHODS: Infants were recruited at vaccine study centres in Montreal, Quebec; Simon Fraser Health Region, British Columbia, and southern Alberta after the protocol had been approved by the relevant institutional ethics committees. Written informed consent was obtained from the parents or guardians of all subjects. At two months of age, the infants were randomly assigned to receive one of three consecutive production lots of DTaP-IPV-Hib by intramuscular injection. Reactions to vaccinations were assessed by parental ...","internal_url":"https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age","translated_internal_url":"","created_at":"2023-01-18T17:17:53.349-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97492000,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492000/thumbnails/1.jpg","file_name":"289842.pdf","download_url":"https://www.academia.edu/attachments/97492000/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Safety_and_Immunogenicity_of_a_Fully_Liq.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492000/289842-libre.pdf?1674106548=\u0026response-content-disposition=attachment%3B+filename%3DSafety_and_Immunogenicity_of_a_Fully_Liq.pdf\u0026Expires=1732452108\u0026Signature=Q2XpJPZB~Zt-mJRfgVBwMGMZZYg3iI9MsxihpkaFHFoLGaV8AvMU~h-D4itE0LRr7nII0cn-46z9J-3ClJEfhAiAFwVXrWVXpIXXz84RO42r30s9oe1oJrcpactnX333w-OW8geBKNsQHZRu0biMXgUcApccZ0ocRIB-wywxTAGJaSdlY~cFAEPKjbjvkuD~SX4NG28hD6nltQfrdcQ3tgyV564jOFqemc1m2q68QjuWACCQqSmsCizZBZMZtcktAS~Oh0NBG6bbewymA8xPRbZizM38VUZzyzxLayY2KDcfCJs0wa-rWCDpz7f1jRO~IkPnse6Fe55apS~n-6OSsQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":97492000,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492000/thumbnails/1.jpg","file_name":"289842.pdf","download_url":"https://www.academia.edu/attachments/97492000/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Safety_and_Immunogenicity_of_a_Fully_Liq.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492000/289842-libre.pdf?1674106548=\u0026response-content-disposition=attachment%3B+filename%3DSafety_and_Immunogenicity_of_a_Fully_Liq.pdf\u0026Expires=1732452108\u0026Signature=Q2XpJPZB~Zt-mJRfgVBwMGMZZYg3iI9MsxihpkaFHFoLGaV8AvMU~h-D4itE0LRr7nII0cn-46z9J-3ClJEfhAiAFwVXrWVXpIXXz84RO42r30s9oe1oJrcpactnX333w-OW8geBKNsQHZRu0biMXgUcApccZ0ocRIB-wywxTAGJaSdlY~cFAEPKjbjvkuD~SX4NG28hD6nltQfrdcQ3tgyV564jOFqemc1m2q68QjuWACCQqSmsCizZBZMZtcktAS~Oh0NBG6bbewymA8xPRbZizM38VUZzyzxLayY2KDcfCJs0wa-rWCDpz7f1jRO~IkPnse6Fe55apS~n-6OSsQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":56615,"name":"Canadian","url":"https://www.academia.edu/Documents/in/Canadian"},{"id":136892,"name":"Immunization","url":"https://www.academia.edu/Documents/in/Immunization"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":243003,"name":"Poliomyelitis","url":"https://www.academia.edu/Documents/in/Poliomyelitis"},{"id":600942,"name":"Tetanus","url":"https://www.academia.edu/Documents/in/Tetanus"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":1817270,"name":"Diphtheria","url":"https://www.academia.edu/Documents/in/Diphtheria"},{"id":2827641,"name":"ORIGINAL ARTICLE","url":"https://www.academia.edu/Documents/in/ORIGINAL_ARTICLE"}],"urls":[{"id":28187308,"url":"http://downloads.hindawi.com/journals/cjidmm/2007/289842.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262306"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262306/An_Evaluation_of_the_Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Diphtheria_and_Tetanus_Toxoid_Vaccine_DTaP_When_Combined_With_a_Haemophilus_influenzaeType_b_Tetanus_Toxoid_Conjugate_Vaccine_PRP_T_in_Taiwanese_Infants"><img alt="Research paper thumbnail of An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and Tetanus Toxoid Vaccine (DTaP) When Combined With a Haemophilus influenzaeType b-Tetanus Toxoid Conjugate Vaccine (PRP-T) in Taiwanese Infants" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262306/An_Evaluation_of_the_Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Diphtheria_and_Tetanus_Toxoid_Vaccine_DTaP_When_Combined_With_a_Haemophilus_influenzaeType_b_Tetanus_Toxoid_Conjugate_Vaccine_PRP_T_in_Taiwanese_Infants">An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and Tetanus Toxoid Vaccine (DTaP) When Combined With a Haemophilus influenzaeType b-Tetanus Toxoid Conjugate Vaccine (PRP-T) in Taiwanese Infants</a></div><div class="wp-workCard_item"><span>Pediatrics</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective. Immunologic interference particular to the Haemophilus influenzae type b (Hib) respons...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective. Immunologic interference particular to the Haemophilus influenzae type b (Hib) response has been observed with previous acellular pertussis-Hib combination vaccines. To test this hypothesis a clinical trial to assess the safety and immunogenicity of a five-component (pertussis toxoid [PT], filamentous hemagglutinin [FHA], pertactin [PRN], and fimbriae 2 and 3 [FIM]), pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP) when given simultaneously with a lyophilized Hib-tetanus toxoid conjugate vaccine (PRP-T) in infants at 2, 4, 6, and 18 months of age was conducted. The study compared two methods of administration: both vaccines combined in a single syringe and administered as a single injection, or both vaccines administered concurrently but at separate sites of injection. Methods. Healthy 2-month-old infants were enrolled at the National Taiwan University Hospital. DTaP, PRP-T, and oral poliomyelitis vaccine (OPV) were given at 2, 4, 6, and 18 months. Re...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262306"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262306"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262306; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262306]").text(description); $(".js-view-count[data-work-id=95262306]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262306; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262306']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262306, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262306]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262306,"title":"An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and Tetanus Toxoid Vaccine (DTaP) When Combined With a Haemophilus influenzaeType b-Tetanus Toxoid Conjugate Vaccine (PRP-T) in Taiwanese Infants","translated_title":"","metadata":{"abstract":"Objective. Immunologic interference particular to the Haemophilus influenzae type b (Hib) response has been observed with previous acellular pertussis-Hib combination vaccines. To test this hypothesis a clinical trial to assess the safety and immunogenicity of a five-component (pertussis toxoid [PT], filamentous hemagglutinin [FHA], pertactin [PRN], and fimbriae 2 and 3 [FIM]), pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP) when given simultaneously with a lyophilized Hib-tetanus toxoid conjugate vaccine (PRP-T) in infants at 2, 4, 6, and 18 months of age was conducted. The study compared two methods of administration: both vaccines combined in a single syringe and administered as a single injection, or both vaccines administered concurrently but at separate sites of injection. Methods. Healthy 2-month-old infants were enrolled at the National Taiwan University Hospital. DTaP, PRP-T, and oral poliomyelitis vaccine (OPV) were given at 2, 4, 6, and 18 months. Re...","publisher":"American Academy of Pediatrics (AAP)","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Pediatrics"},"translated_abstract":"Objective. Immunologic interference particular to the Haemophilus influenzae type b (Hib) response has been observed with previous acellular pertussis-Hib combination vaccines. To test this hypothesis a clinical trial to assess the safety and immunogenicity of a five-component (pertussis toxoid [PT], filamentous hemagglutinin [FHA], pertactin [PRN], and fimbriae 2 and 3 [FIM]), pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP) when given simultaneously with a lyophilized Hib-tetanus toxoid conjugate vaccine (PRP-T) in infants at 2, 4, 6, and 18 months of age was conducted. The study compared two methods of administration: both vaccines combined in a single syringe and administered as a single injection, or both vaccines administered concurrently but at separate sites of injection. Methods. Healthy 2-month-old infants were enrolled at the National Taiwan University Hospital. DTaP, PRP-T, and oral poliomyelitis vaccine (OPV) were given at 2, 4, 6, and 18 months. Re...","internal_url":"https://www.academia.edu/95262306/An_Evaluation_of_the_Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Diphtheria_and_Tetanus_Toxoid_Vaccine_DTaP_When_Combined_With_a_Haemophilus_influenzaeType_b_Tetanus_Toxoid_Conjugate_Vaccine_PRP_T_in_Taiwanese_Infants","translated_internal_url":"","created_at":"2023-01-18T17:17:53.207-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"An_Evaluation_of_the_Safety_and_Immunogenicity_of_a_Five_Component_Acellular_Pertussis_Diphtheria_and_Tetanus_Toxoid_Vaccine_DTaP_When_Combined_With_a_Haemophilus_influenzaeType_b_Tetanus_Toxoid_Conjugate_Vaccine_PRP_T_in_Taiwanese_Infants","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics"},{"id":11558,"name":"Drug interactions","url":"https://www.academia.edu/Documents/in/Drug_interactions"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":94451,"name":"Taiwan","url":"https://www.academia.edu/Documents/in/Taiwan"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine"},{"id":600942,"name":"Tetanus","url":"https://www.academia.edu/Documents/in/Tetanus"},{"id":1250233,"name":"Tetanus Toxoid","url":"https://www.academia.edu/Documents/in/Tetanus_Toxoid"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":1490453,"name":"Whooping Cough","url":"https://www.academia.edu/Documents/in/Whooping_Cough"},{"id":1533489,"name":"Haemophilus Infections Market","url":"https://www.academia.edu/Documents/in/Haemophilus_Infections_Market"},{"id":1817270,"name":"Diphtheria","url":"https://www.academia.edu/Documents/in/Diphtheria"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":28187307,"url":"https://publications.aap.org/pediatrics/article-pdf/103/1/25/841205/25.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262305"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262305/COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLULAR_PERTUSSIS_INACTIVATED_POLIO_DTaP_IPV_VACCINE_USED_TO_RECONSTITUTE_LYOPHILIZED_H_INFLUENZAE_B_PRP_T_OR_LICENSED_DTwP_IPV_PRP_T_VACCINE_IN_INFANTS_743"><img alt="Research paper thumbnail of COMPARATIVE IMMUNOGENICITY OF AN ACELLULAR PERTUSSIS -INACTIVATED POLIO(DTaP-IPV) VACCINE USED TO RECONSTITUTE LYOPHILIZED H. INFLUENZAE B(PRP-T) OR LICENSED DTwP-IPV-PRP-T VACCINE IN INFANTS † 743" class="work-thumbnail" src="https://attachments.academia-assets.com/97492017/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262305/COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLULAR_PERTUSSIS_INACTIVATED_POLIO_DTaP_IPV_VACCINE_USED_TO_RECONSTITUTE_LYOPHILIZED_H_INFLUENZAE_B_PRP_T_OR_LICENSED_DTwP_IPV_PRP_T_VACCINE_IN_INFANTS_743">COMPARATIVE IMMUNOGENICITY OF AN ACELLULAR PERTUSSIS -INACTIVATED POLIO(DTaP-IPV) VACCINE USED TO RECONSTITUTE LYOPHILIZED H. INFLUENZAE B(PRP-T) OR LICENSED DTwP-IPV-PRP-T VACCINE IN INFANTS † 743</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, 1997</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8bdc5cd7a7334301cec3cd3e701c3e21" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97492017,"asset_id":95262305,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97492017/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262305"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262305"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262305; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262305]").text(description); $(".js-view-count[data-work-id=95262305]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262305; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262305']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262305, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8bdc5cd7a7334301cec3cd3e701c3e21" } } $('.js-work-strip[data-work-id=95262305]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262305,"title":"COMPARATIVE IMMUNOGENICITY OF AN ACELLULAR PERTUSSIS -INACTIVATED POLIO(DTaP-IPV) VACCINE USED TO RECONSTITUTE LYOPHILIZED H. INFLUENZAE B(PRP-T) OR LICENSED DTwP-IPV-PRP-T VACCINE IN INFANTS † 743","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Pediatric Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/95262305/COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLULAR_PERTUSSIS_INACTIVATED_POLIO_DTaP_IPV_VACCINE_USED_TO_RECONSTITUTE_LYOPHILIZED_H_INFLUENZAE_B_PRP_T_OR_LICENSED_DTwP_IPV_PRP_T_VACCINE_IN_INFANTS_743","translated_internal_url":"","created_at":"2023-01-18T17:17:53.031-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97492017,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492017/thumbnails/1.jpg","file_name":"pr1997922.pdf","download_url":"https://www.academia.edu/attachments/97492017/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLUL.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492017/pr1997922-libre.pdf?1674106542=\u0026response-content-disposition=attachment%3B+filename%3DCOMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLUL.pdf\u0026Expires=1732452108\u0026Signature=Z~3OcOuwgkZN8cri8xFfovVNrmUZ06EzcdE4UIjARcfRJynASX~tLuJBaR6FWMPzKm59tgypvF0L4bWrQeALWlb8gY00XdUuTQZCd3xS4yMF1lSE0BD4zSZW9pQfQuUUUCBmuLYUVD3MF-hLLDlw2rYd16r8PqS4dFVaYobs9oiX~uZK4e6bBKFq-Ned1B03Qb9kBYV0fAEl45i3~dCa6AVYSkooQtNtIDn5UmgrLTovBgMvrdubUpYhTaGFzpyxF2MOzHvPRUeRT3VLaBm-h-ctJO-mGyZK14rFP3M~xTk7v8iCh66tK60EcO1v-g-0zBcuf2hYHxY5M0j4ahsV-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLULAR_PERTUSSIS_INACTIVATED_POLIO_DTaP_IPV_VACCINE_USED_TO_RECONSTITUTE_LYOPHILIZED_H_INFLUENZAE_B_PRP_T_OR_LICENSED_DTwP_IPV_PRP_T_VACCINE_IN_INFANTS_743","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":97492017,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97492017/thumbnails/1.jpg","file_name":"pr1997922.pdf","download_url":"https://www.academia.edu/attachments/97492017/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"COMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLUL.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97492017/pr1997922-libre.pdf?1674106542=\u0026response-content-disposition=attachment%3B+filename%3DCOMPARATIVE_IMMUNOGENICITY_OF_AN_ACELLUL.pdf\u0026Expires=1732452108\u0026Signature=Z~3OcOuwgkZN8cri8xFfovVNrmUZ06EzcdE4UIjARcfRJynASX~tLuJBaR6FWMPzKm59tgypvF0L4bWrQeALWlb8gY00XdUuTQZCd3xS4yMF1lSE0BD4zSZW9pQfQuUUUCBmuLYUVD3MF-hLLDlw2rYd16r8PqS4dFVaYobs9oiX~uZK4e6bBKFq-Ned1B03Qb9kBYV0fAEl45i3~dCa6AVYSkooQtNtIDn5UmgrLTovBgMvrdubUpYhTaGFzpyxF2MOzHvPRUeRT3VLaBm-h-ctJO-mGyZK14rFP3M~xTk7v8iCh66tK60EcO1v-g-0zBcuf2hYHxY5M0j4ahsV-w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95262292"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95262292/Controlled_trial_of_Haemophilus_influenzae_type_B_diphtheria_toxoid_conjugate_combined_with_diphtheria_tetanus_and_pertussis_vaccines_in_18_month_old_children_including_comparison_of_arm_versus_thigh_injection"><img alt="Research paper thumbnail of Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95262292/Controlled_trial_of_Haemophilus_influenzae_type_B_diphtheria_toxoid_conjugate_combined_with_diphtheria_tetanus_and_pertussis_vaccines_in_18_month_old_children_including_comparison_of_arm_versus_thigh_injection">Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 1992</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A randomized, controlled comparison was made in 175 healthy 18-month-old children given either di...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP-PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95262292"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95262292"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95262292; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95262292]").text(description); $(".js-view-count[data-work-id=95262292]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95262292; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95262292']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95262292, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95262292]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95262292,"title":"Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection","translated_title":"","metadata":{"abstract":"A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP-PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1992,"errors":{}},"publication_name":"Vaccine"},"translated_abstract":"A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP-PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.","internal_url":"https://www.academia.edu/95262292/Controlled_trial_of_Haemophilus_influenzae_type_B_diphtheria_toxoid_conjugate_combined_with_diphtheria_tetanus_and_pertussis_vaccines_in_18_month_old_children_including_comparison_of_arm_versus_thigh_injection","translated_internal_url":"","created_at":"2023-01-18T17:17:27.227-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Controlled_trial_of_Haemophilus_influenzae_type_B_diphtheria_toxoid_conjugate_combined_with_diphtheria_tetanus_and_pertussis_vaccines_in_18_month_old_children_including_comparison_of_arm_versus_thigh_injection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":128538,"name":"Arm","url":"https://www.academia.edu/Documents/in/Arm"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":150847,"name":"Vaccine","url":"https://www.academia.edu/Documents/in/Vaccine"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial"},{"id":462777,"name":"Leg","url":"https://www.academia.edu/Documents/in/Leg"},{"id":600942,"name":"Tetanus","url":"https://www.academia.edu/Documents/in/Tetanus"},{"id":1817270,"name":"Diphtheria","url":"https://www.academia.edu/Documents/in/Diphtheria"},{"id":1944474,"name":"Diphtheria Toxin","url":"https://www.academia.edu/Documents/in/Diphtheria_Toxin"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87112351"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87112351/Vaccines_Acellular_Pertussis_and_Methods_for_Manufacturing"><img alt="Research paper thumbnail of Vaccines, Acellular Pertussis and Methods for Manufacturing" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87112351/Vaccines_Acellular_Pertussis_and_Methods_for_Manufacturing">Vaccines, Acellular Pertussis and Methods for Manufacturing</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87112351"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87112351"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87112351; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87112351]").text(description); $(".js-view-count[data-work-id=87112351]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87112351; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87112351']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87112351, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87112351]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87112351,"title":"Vaccines, Acellular Pertussis and Methods for Manufacturing","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1996,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/87112351/Vaccines_Acellular_Pertussis_and_Methods_for_Manufacturing","translated_internal_url":"","created_at":"2022-09-22T19:53:52.803-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Vaccines_Acellular_Pertussis_and_Methods_for_Manufacturing","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87112344"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87112344/Multivalent_DTP_Polio_Vaccines"><img alt="Research paper thumbnail of Multivalent DTP-Polio Vaccines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87112344/Multivalent_DTP_Polio_Vaccines">Multivalent DTP-Polio Vaccines</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87112344"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87112344"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87112344; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87112344]").text(description); $(".js-view-count[data-work-id=87112344]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87112344; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87112344']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87112344, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87112344]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87112344,"title":"Multivalent DTP-Polio Vaccines","translated_title":"","metadata":{"publication_date":{"day":20,"month":9,"year":2006,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/87112344/Multivalent_DTP_Polio_Vaccines","translated_internal_url":"","created_at":"2022-09-22T19:53:40.899-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Multivalent_DTP_Polio_Vaccines","translated_slug":"","page_count":null,"language":"es","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[],"research_interests":[],"urls":[{"id":24079113,"url":"http://www.freepatentsonline.com/EP0914153.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69809780"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69809780/Conquering_the_crippler_Canada_and_the_eradication_of_polio"><img alt="Research paper thumbnail of Conquering the crippler: Canada and the eradication of polio" class="work-thumbnail" src="https://attachments.academia-assets.com/79762841/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69809780/Conquering_the_crippler_Canada_and_the_eradication_of_polio">Conquering the crippler: Canada and the eradication of polio</a></div><div class="wp-workCard_item"><span>Canadian journal of public …</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d8488a8f8dcc188763a19c47818653c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":79762841,"asset_id":69809780,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/79762841/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69809780"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69809780"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69809780; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69809780]").text(description); $(".js-view-count[data-work-id=69809780]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69809780; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69809780']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69809780, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5d8488a8f8dcc188763a19c47818653c" } } $('.js-work-strip[data-work-id=69809780]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69809780,"title":"Conquering the crippler: Canada and the eradication of polio","translated_title":"","metadata":{"publisher":"cat.inist.fr","grobid_abstract":"with the advice of a multi-agency working group, embarked on a review of the literature to examine the issues and barriers related to Canadian population and public health (PPH) knowledge generation, dissemination and exchange, and uptake. The literature review was complemented by interviews with more than 30 Canadian, American, and United Kingdom organizations that are active in PPH research, especially synthesis research. Research organizations were asked about the mechanisms they use to support PPH research generation, synthesis, transfer, and exchange, as well as their impressions of the need for new Canadian organizational structures to encourage a more integrated approach to these tasks, including challenges to be addressed. This research project complements and builds on previous work of the CIHR-IPPH* (in partnership with the Canadian Institute for Health Information, Canadian Population Health Initiative (CIHI-CPHI)), which consulted PPH researchers, practitioners, and policy-makers to identify research and knowledge transfer and exchange priorities in population and public health. During these consultation sessions, a number of challenges and opportunities were raised in relation to the synthesis, exchange and transfer of the","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Canadian journal of public …","grobid_abstract_attachment_id":79762841},"translated_abstract":null,"internal_url":"https://www.academia.edu/69809780/Conquering_the_crippler_Canada_and_the_eradication_of_polio","translated_internal_url":"","created_at":"2022-01-28T10:20:27.861-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":79762841,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/79762841/thumbnails/1.jpg","file_name":"Conquering_the_crippler_Canada_and_the_e20220128-18481-6n3le3.pdf","download_url":"https://www.academia.edu/attachments/79762841/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Conquering_the_crippler_Canada_and_the_e.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/79762841/Conquering_the_crippler_Canada_and_the_e20220128-18481-6n3le3.pdf?1643394093=\u0026response-content-disposition=attachment%3B+filename%3DConquering_the_crippler_Canada_and_the_e.pdf\u0026Expires=1732452108\u0026Signature=LJTo5QBGEMD-h5TLIwLKMx5tuxrP1kTxPoXhWUm11HMkAv7aR6Aiz8-QVX7RlMAu5LCtmRlN40hwjJQwHWOUukF-85uwf6KpU0-9F696rwJTgEniADknBJQ4KCoIfwUDZbT1ySlROdVegI4XBhvZZEuuQlRCY9XEVyLQnyVQmUaY-qf3rYh~My947YCAaZ2aeYhVwV7B1NgKPll0W6q2XzRvD-mtFKSQj~VkxK-ShRfcRQVk~zhmlpZJVUPs15xGFTQUAsnf8Gpvm5WmtqbuzrOzwxxe~vavbFZeyfcGTIJTaBl0LuuYlFH9cIzgjWYNahuMIvBpveEqaGSWM3Hm6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Conquering_the_crippler_Canada_and_the_eradication_of_polio","translated_slug":"","page_count":19,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":79762841,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/79762841/thumbnails/1.jpg","file_name":"Conquering_the_crippler_Canada_and_the_e20220128-18481-6n3le3.pdf","download_url":"https://www.academia.edu/attachments/79762841/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Conquering_the_crippler_Canada_and_the_e.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/79762841/Conquering_the_crippler_Canada_and_the_e20220128-18481-6n3le3.pdf?1643394093=\u0026response-content-disposition=attachment%3B+filename%3DConquering_the_crippler_Canada_and_the_e.pdf\u0026Expires=1732452108\u0026Signature=LJTo5QBGEMD-h5TLIwLKMx5tuxrP1kTxPoXhWUm11HMkAv7aR6Aiz8-QVX7RlMAu5LCtmRlN40hwjJQwHWOUukF-85uwf6KpU0-9F696rwJTgEniADknBJQ4KCoIfwUDZbT1ySlROdVegI4XBhvZZEuuQlRCY9XEVyLQnyVQmUaY-qf3rYh~My947YCAaZ2aeYhVwV7B1NgKPll0W6q2XzRvD-mtFKSQj~VkxK-ShRfcRQVk~zhmlpZJVUPs15xGFTQUAsnf8Gpvm5WmtqbuzrOzwxxe~vavbFZeyfcGTIJTaBl0LuuYlFH9cIzgjWYNahuMIvBpveEqaGSWM3Hm6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":54114,"name":"Canada","url":"https://www.academia.edu/Documents/in/Canada"},{"id":57907,"name":"Disease Outbreaks","url":"https://www.academia.edu/Documents/in/Disease_Outbreaks"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":243003,"name":"Poliomyelitis","url":"https://www.academia.edu/Documents/in/Poliomyelitis"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":485238,"name":"Canadian Public Policy","url":"https://www.academia.edu/Documents/in/Canadian_Public_Policy"},{"id":508371,"name":"Curriculum and Pedagogy","url":"https://www.academia.edu/Documents/in/Curriculum_and_Pedagogy"},{"id":1852990,"name":"Canadian Public Health Policy","url":"https://www.academia.edu/Documents/in/Canadian_Public_Health_Policy"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62383392"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62383392/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication"><img alt="Research paper thumbnail of Polio vaccine development in Canada: Contributions to global polio eradication" class="work-thumbnail" src="https://attachments.academia-assets.com/75167119/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62383392/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication">Polio vaccine development in Canada: Contributions to global polio eradication</a></div><div class="wp-workCard_item"><span>Biologicals</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d00e215dcbabb8b9d0a2fb7610e92231" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75167119,"asset_id":62383392,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75167119/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62383392"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62383392"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62383392; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=62383392]").text(description); $(".js-view-count[data-work-id=62383392]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 62383392; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='62383392']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 62383392, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d00e215dcbabb8b9d0a2fb7610e92231" } } $('.js-work-strip[data-work-id=62383392]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":62383392,"title":"Polio vaccine development in Canada: Contributions to global polio eradication","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Biologicals"},"translated_abstract":null,"internal_url":"https://www.academia.edu/62383392/Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication","translated_internal_url":"","created_at":"2021-11-25T11:25:47.191-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38584614,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75167119,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75167119/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/75167119/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75167119/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1637869233=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=bGvPrnAcaVjkUbVgVoOb9mYZVWjV5rD~0AOhHpG6NM0cUPQoS4dqAfA2W-MENXG~ObwWqZJeLik9WryG2oHlRqcSYT4De8nNzwTKUy~UodgKhxblEIqLuCH52ITQxi-lnfR9V6~c2IZcFbSmJMrVN4vv1gJ5oRTwf6DVz1dFz0ONxxY3y3Z3RqM5tSWlFLDjRj6rn-eJ6p84~MkX2R7KyruNAvDnjy89fLPdpYRUSjFALRVEcR5vHl2~WncmUSXykgQfszP~mybFDg-XBDeWyHt2YPMBy4ZRdj3diEvrK5NqV~1jV2bkKP8vE2tc2SGm0y-uRP~ylcY-jA0Ho2v1-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Polio_vaccine_development_in_Canada_Contributions_to_global_polio_eradication","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":38584614,"first_name":"Luis","middle_initials":null,"last_name":"Barreto","page_name":"LuisBarreto","domain_name":"nrc-ca","created_at":"2015-11-17T19:36:18.510-08:00","display_name":"Luis Barreto","url":"https://nrc-ca.academia.edu/LuisBarreto"},"attachments":[{"id":75167119,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75167119/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/75167119/download_file?st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&st=MTczMjQ0ODUwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75167119/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1637869233=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=bGvPrnAcaVjkUbVgVoOb9mYZVWjV5rD~0AOhHpG6NM0cUPQoS4dqAfA2W-MENXG~ObwWqZJeLik9WryG2oHlRqcSYT4De8nNzwTKUy~UodgKhxblEIqLuCH52ITQxi-lnfR9V6~c2IZcFbSmJMrVN4vv1gJ5oRTwf6DVz1dFz0ONxxY3y3Z3RqM5tSWlFLDjRj6rn-eJ6p84~MkX2R7KyruNAvDnjy89fLPdpYRUSjFALRVEcR5vHl2~WncmUSXykgQfszP~mybFDg-XBDeWyHt2YPMBy4ZRdj3diEvrK5NqV~1jV2bkKP8vE2tc2SGm0y-uRP~ylcY-jA0Ho2v1-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":75167120,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75167120/thumbnails/1.jpg","file_name":"Polio-Biologicals34-2-June2006sdarticle.pdf","download_url":"https://www.academia.edu/attachments/75167120/download_file","bulk_download_file_name":"Polio_vaccine_development_in_Canada_Cont.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75167120/Polio-Biologicals34-2-June2006sdarticle-libre.pdf?1637869233=\u0026response-content-disposition=attachment%3B+filename%3DPolio_vaccine_development_in_Canada_Cont.pdf\u0026Expires=1732452108\u0026Signature=XVLOJkEKXmsisS3nErMKbaFGuIoJhO-W9Gw-TLlRjXiFJ9p2uRjxpeis2pYDSultgUiGv9D6wyA7qWAd8ImMTKQ-PGqgszb~DFLOFGYzU5p0PwqeQMzUBOiIuLkcdVSowQiC-DT6PSnTOx0ICxy5fTuFJ~S6k5Q69vxKed~ApGA3S5YNCx95d19wZWDM157-CGjGbVW-R4JapkodQHtjXlvINSkiKX-A-ieEb8OT9DQ46x-8bCVPmkyEzV4lt1uDJEUV~~GwAWyBl5x1CIX1Wwaj~eR~bJm0ekgpvAzhYrE7Z41KLmrSlYGsvUuirSd3LMpO2BAn~kJVVfuqSaVtMw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines"},{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health"},{"id":6553,"name":"History of Public Health","url":"https://www.academia.edu/Documents/in/History_of_Public_Health"},{"id":8920,"name":"History of Canada","url":"https://www.academia.edu/Documents/in/History_of_Canada"},{"id":17969,"name":"Health Policy","url":"https://www.academia.edu/Documents/in/Health_Policy"},{"id":24389,"name":"Poliomyelitis (History)","url":"https://www.academia.edu/Documents/in/Poliomyelitis_History_"},{"id":37800,"name":"Vaccine development","url":"https://www.academia.edu/Documents/in/Vaccine_development"},{"id":42737,"name":"Poliorcetics","url":"https://www.academia.edu/Documents/in/Poliorcetics"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":54114,"name":"Canada","url":"https://www.academia.edu/Documents/in/Canada"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":243003,"name":"Poliomyelitis","url":"https://www.academia.edu/Documents/in/Poliomyelitis"},{"id":650891,"name":"Biologicals","url":"https://www.academia.edu/Documents/in/Biologicals"}],"urls":[{"id":14483944,"url":"http://www.healthheritageresearch.com/Polio-Biologicals34-2-June2006sdarticle.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "aa988cc3dc0ede5799d71f958b1eeb1ba5d36e22c8b9ee765504c81002149cc6", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="W0wRdQ+qcdJfqI/4yA8K3BSYodT2K4WrUTJAZ74Tn6/w+YjT7If0a1fXlcQtawcBHT5+CY11rOv15Q1lYxOuKA==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://nrc-ca.academia.edu/LuisBarreto" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="jhs/uQMa/B3Bz1tB+5u7+HjZXB55QQOS16DJt230uqclrqYf4Dd5pMmwQX0e/7YlcX+DwwIfKtJzd4S1sPSLIA==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>