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Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy"}],"publication_year":2008,"publication_year_with_fallback":2008,"paper_rank":null,"all_time_views":13,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_8285356" data-work_id="8285356" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/8285356/Identification_characterization_and_potent_antitumor_activity_of_ECO4601_a_novel_peripheral_benzodiazepine_receptor_ligand">Identification, characterization and potent antitumor activity of ECO4601, a novel peripheral benzodiazepine receptor ligand</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose ECO-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through DECIPHER® technology, Thallion’s proprietary drug discovery platform. The compound was shown to have a broad cytotoxic activity in the low... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_8285356" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose ECO-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through DECIPHER® technology, Thallion’s proprietary drug discovery platform. The compound was shown to have a broad cytotoxic activity in the low micromolar range when tested in the NCI 60 cell line panel. In the work presented here, ECO-4601 was further evaluated against brain tumor cell lines. Preliminary mechanistic studies as well as in vivo antitumor evaluation were performed. Methods Since ECO-4601 has a benzodiazepinone moiety, we first investigated if it binds the central and/or peripheral benzodiazepine receptors. ECO-4601 was tested in radioligand binding assays on benzodiazepine receptors obtained from rat hearts. The ability of ECO-4601 to inhibit the growth of CNS cancers was evaluated on a panel of mouse, rat and human glioma cell lines using a standard MTT assay. Antitumor efficacy studies were performed on gliomas (rat and human), human breast and human prostate mouse tumor xenografts. Antitumor activity and pharmacokinetic analysis of ECO-4601 was evaluated following intravenous (IV), subcutaneous (SC), and intraperitoneal (IP) bolus administrations. Results ECO-4601 was shown to bind the peripheral but not the central benzodiazepine receptor and inhibited the growth of CNS tumor cell lines. Bolus SC and IP administration gave rise to low but sustained drug exposure, and resulted in moderate to significant antitumor activity at doses that were well tolerated. In a rat glioma (C6) xenograft model, ECO-4601 produced up to 70% tumor growth inhibition (TGI) while in a human glioma (U-87MG) xenograft, TGI was 34%. Antitumor activity was highly significant in both human hormone-independent breast (MDA-MB-231) and prostate (PC-3) xenografts, resulting in TGI of 72 and 100%, respectively. On the other hand, IV dosing was followed by rapid elimination of the drug and was ineffective. Conclusions Antitumor efficacy of ECO-4601 appears to be associated with the exposure parameter AUC and/or sustained drug levels rather than C max. These in vivo data constitute a rationale for clinical studies testing prolonged continuous administration of ECO-4601.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/8285356" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="764b2c516a792dc7998e06893acc9a80" rel="nofollow" data-download="{"attachment_id":48154902,"asset_id":8285356,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48154902/download_file?st=MTczMjQ1NzE1MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16445012" href="https://nrc-ca.academia.edu/BryanSimard">Bryan Simard</a><script data-card-contents-for-user="16445012" type="text/json">{"id":16445012,"first_name":"Bryan","last_name":"Simard","domain_name":"nrc-ca","page_name":"BryanSimard","display_name":"Bryan Simard","profile_url":"https://nrc-ca.academia.edu/BryanSimard","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_8285356 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="8285356"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 8285356, container: ".js-paper-rank-work_8285356", }); 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The compound was shown to have a broad cytotoxic activity in the low micromolar range when tested in the NCI 60 cell line panel. In the work presented here, ECO-4601 was further evaluated against brain tumor cell lines. Preliminary mechanistic studies as well as in vivo antitumor evaluation were performed. Methods Since ECO-4601 has a benzodiazepinone moiety, we first investigated if it binds the central and/or peripheral benzodiazepine receptors. ECO-4601 was tested in radioligand binding assays on benzodiazepine receptors obtained from rat hearts. The ability of ECO-4601 to inhibit the growth of CNS cancers was evaluated on a panel of mouse, rat and human glioma cell lines using a standard MTT assay. Antitumor efficacy studies were performed on gliomas (rat and human), human breast and human prostate mouse tumor xenografts. Antitumor activity and pharmacokinetic analysis of ECO-4601 was evaluated following intravenous (IV), subcutaneous (SC), and intraperitoneal (IP) bolus administrations. Results ECO-4601 was shown to bind the peripheral but not the central benzodiazepine receptor and inhibited the growth of CNS tumor cell lines. Bolus SC and IP administration gave rise to low but sustained drug exposure, and resulted in moderate to significant antitumor activity at doses that were well tolerated. In a rat glioma (C6) xenograft model, ECO-4601 produced up to 70% tumor growth inhibition (TGI) while in a human glioma (U-87MG) xenograft, TGI was 34%. Antitumor activity was highly significant in both human hormone-independent breast (MDA-MB-231) and prostate (PC-3) xenografts, resulting in TGI of 72 and 100%, respectively. On the other hand, IV dosing was followed by rapid elimination of the drug and was ineffective. Conclusions Antitumor efficacy of ECO-4601 appears to be associated with the exposure parameter AUC and/or sustained drug levels rather than C max. These in vivo data constitute a rationale for clinical studies testing prolonged continuous administration of ECO-4601.","publication":"Cancer Chemotherapy and Pharmacology","publication_with_fallback":"Cancer Chemotherapy and 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novel peripheral benzodiazepine receptor ligand</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Erratum to: Cancer Chemother Pharmacol (2008) 61:911–921 DOI 10.1007/s00280-007-0544-2In this article the authors list has been revised to the following: Henriette Gourdeau, James B. McAlpine, Maxime Ranger, Bryan Simard, Francois Berger,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_8285357" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Erratum to: Cancer Chemother Pharmacol (2008) 61:911–921 DOI 10.1007/s00280-007-0544-2In this article the authors list has been revised to the following: Henriette Gourdeau, James B. McAlpine, Maxime Ranger, Bryan Simard, Francois Berger, Francis Beaudry, Chris M. Farnet and Pierre Falardeau.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/8285357" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c2028eb88ffefb0e30b62933a11b859e" rel="nofollow" data-download="{"attachment_id":48154932,"asset_id":8285357,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48154932/download_file?st=MTczMjQ1NzE1MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16445012" href="https://nrc-ca.academia.edu/BryanSimard">Bryan Simard</a><script data-card-contents-for-user="16445012" type="text/json">{"id":16445012,"first_name":"Bryan","last_name":"Simard","domain_name":"nrc-ca","page_name":"BryanSimard","display_name":"Bryan Simard","profile_url":"https://nrc-ca.academia.edu/BryanSimard","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_8285357 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="8285357"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 8285357, container: ".js-paper-rank-work_8285357", }); 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growth factor-mediated biological effects</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, which exerts direct effects on vascular endothelial cells, including endothelial cell proliferation and survival, tubulogenesis, and vascular permeability.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17536425" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, which exerts direct effects on vascular endothelial cells, including endothelial cell proliferation and survival, tubulogenesis, and vascular permeability. In this study, we examined whether Neovastat, a naturally occurring multifunctional antiangiogenic drug, could inhibit the endothelial cell response to VEGF stimulation. We demonstrated that Neovastat was able to block the VEGF-dependent microvessel sprouting from Matrigel-embedded rat aortic rings, and it also blocked the VEGF-induced endothelial cell tubulogenesis in vitro. In vivo studies showed that Neovastat was able to specifically inhibit VEGF-induced plasma extravasation in numerous tissues, including pancreas and skin. The mechanism of action of Neovastat on VEGF-mediated effects was also evaluated at the molecular level. Neovastat was shown to compete against the binding of VEGF to its receptor in endothelial cells and significantly inhibit...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17536425" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1d67e232bba38a0fc74182b8ca75993b" rel="nofollow" data-download="{"attachment_id":39565393,"asset_id":17536425,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39565393/download_file?st=MTczMjQ1NzE1MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37313423" href="https://independent.academia.edu/PierreSirois">Pierre Sirois</a><script data-card-contents-for-user="37313423" type="text/json">{"id":37313423,"first_name":"Pierre","last_name":"Sirois","domain_name":"independent","page_name":"PierreSirois","display_name":"Pierre Sirois","profile_url":"https://independent.academia.edu/PierreSirois","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-17536425">+3</span><div class="hidden js-additional-users-17536425"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://nrc-ca.academia.edu/BryanSimard">Bryan Simard</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/EdithBeaulieu">Edith Beaulieu</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://cancer.academia.edu/WilliamFigg">William Figg</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-17536425'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-17536425').html(); 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href="https://www.academia.edu/47771234/The_Antiangiogenic_Agent_Neovastat_%C3%86_941_Inhibits_Vascular_Endothelial_Growth_Factor_mediated_Biological_Effects">The Antiangiogenic Agent Neovastat (Æ-941) Inhibits Vascular Endothelial Growth Factor-mediated Biological Effects</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47771234" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b73478931da09bce7d425216c195a390" rel="nofollow" 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class="clearfix u-pv7x u-mb0x js-work-card work_94967992" data-work_id="94967992" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/94967992/The_antiangiogenic_agent_neovastat_AE_941_inhibits_vascular_endothelial_growth_factor_mediated_biological_effects">The antiangiogenic agent neovastat (AE-941) inhibits vascular endothelial growth factor-mediated biological effects</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, which exerts direct effects on vascular endothelial cells, including endothelial cell proliferation and survival, tubulogenesis, and vascular permeability.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_94967992" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, which exerts direct effects on vascular endothelial cells, including endothelial cell proliferation and survival, tubulogenesis, and vascular permeability. In this study, we examined whether Neovastat, a naturally occurring multifunctional antiangiogenic drug, could inhibit the endothelial cell response to VEGF stimulation. We demonstrated that Neovastat was able to block the VEGF-dependent microvessel sprouting from Matrigel-embedded rat aortic rings, and it also blocked the VEGF-induced endothelial cell tubulogenesis in vitro. In vivo studies showed that Neovastat was able to specifically inhibit VEGF-induced plasma extravasation in numerous tissues, including pancreas and skin. The mechanism of action of Neovastat on VEGF-mediated effects was also evaluated at the molecular level. Neovastat was shown to compete against the binding of VEGF to its receptor in endothelial cells and significantly inhibit...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/94967992" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="960f55ccef111c800de2318e55b54ef9" rel="nofollow" data-download="{"attachment_id":97280809,"asset_id":94967992,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/97280809/download_file?st=MTczMjQ1NzE1Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16445012" href="https://nrc-ca.academia.edu/BryanSimard">Bryan Simard</a><script data-card-contents-for-user="16445012" type="text/json">{"id":16445012,"first_name":"Bryan","last_name":"Simard","domain_name":"nrc-ca","page_name":"BryanSimard","display_name":"Bryan Simard","profile_url":"https://nrc-ca.academia.edu/BryanSimard","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_94967992 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="94967992"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 94967992, container: ".js-paper-rank-work_94967992", }); 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In this study, we examined whether Neovastat, a naturally occurring multifunctional antiangiogenic drug, could inhibit the endothelial cell response to VEGF stimulation. We demonstrated that Neovastat was able to block the VEGF-dependent microvessel sprouting from Matrigel-embedded rat aortic rings, and it also blocked the VEGF-induced endothelial cell tubulogenesis in vitro. In vivo studies showed that Neovastat was able to specifically inhibit VEGF-induced plasma extravasation in numerous tissues, including pancreas and skin. The mechanism of action of Neovastat on VEGF-mediated effects was also evaluated at the molecular level. 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href="https://www.academia.edu/94967993/Etude_Des_Effets_De_LExtrait_De_Cartilage_De_Requin_et_Du_TLN_4601_Sur_Le_Glioblastome_Chez_La_Souris_GR_Ace_Aux_Technologies_Transcriptomiques_et_Proteomiques">Etude Des Effets De L'Extrait De Cartilage De Requin et Du TLN-4601 Sur Le Glioblastome Chez La Souris GR ^ Ace Aux Technologies Transcriptomiques et Proteomiques</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Le glioblastome represente le grade le plus eleve des tumeurs cerebrales. Sa croissance est favorisee par une forte neovascularisation de meme que par l&#39;activation de la voie du recepteur a l&#39;EGFR-Ras. La premiere partie montre... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_94967993" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Le glioblastome represente le grade le plus eleve des tumeurs cerebrales. Sa croissance est favorisee par une forte neovascularisation de meme que par l&#39;activation de la voie du recepteur a l&#39;EGFR-Ras. La premiere partie montre l&#39;effet antiangiogenique et antitumoral de l&#39;extrait de cartilage dans plusieurs modeles de glioblastome chez la souris. L&#39;etude du transcriptome des cellules endotheliales a permise de proposer des mecanismes d&#39;actions. Il a ete propose que l&#39;extrait de cartilage induise la secretion de cytokines, qui entrainent la generation de derives reactifs de l&#39;oxygene. Ceux-ci entraineraient l&#39;activation du NFkB qui induirait l&#39;expression d&#39;un premier reseau de genes impliques dans l&#39;inflammation de l&#39;endothelium en croissance. La co-administration de corticoides pour reduire l&#39;œdeme tumoral a d&#39;ailleurs entraine une perte de l&#39;efficacite in vivo et serait donc a proscrire en clinique. L&#39;extrait de ca...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/94967993" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1891c49d7e9b5329acda7d2e7c6804f6" rel="nofollow" data-download="{"attachment_id":97280791,"asset_id":94967993,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/97280791/download_file?st=MTczMjQ1NzE1Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16445012" href="https://nrc-ca.academia.edu/BryanSimard">Bryan Simard</a><script data-card-contents-for-user="16445012" type="text/json">{"id":16445012,"first_name":"Bryan","last_name":"Simard","domain_name":"nrc-ca","page_name":"BryanSimard","display_name":"Bryan Simard","profile_url":"https://nrc-ca.academia.edu/BryanSimard","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_94967993 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="94967993"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 94967993, container: ".js-paper-rank-work_94967993", }); 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Sa croissance est favorisee par une forte neovascularisation de meme que par l\u0026#39;activation de la voie du recepteur a l\u0026#39;EGFR-Ras. La premiere partie montre l\u0026#39;effet antiangiogenique et antitumoral de l\u0026#39;extrait de cartilage dans plusieurs modeles de glioblastome chez la souris. L\u0026#39;etude du transcriptome des cellules endotheliales a permise de proposer des mecanismes d\u0026#39;actions. Il a ete propose que l\u0026#39;extrait de cartilage induise la secretion de cytokines, qui entrainent la generation de derives reactifs de l\u0026#39;oxygene. Ceux-ci entraineraient l\u0026#39;activation du NFkB qui induirait l\u0026#39;expression d\u0026#39;un premier reseau de genes impliques dans l\u0026#39;inflammation de l\u0026#39;endothelium en croissance. La co-administration de corticoides pour reduire l\u0026#39;œdeme tumoral a d\u0026#39;ailleurs entraine une perte de l\u0026#39;efficacite in vivo et serait donc a proscrire en clinique. 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itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18548992/Safety_and_immunogenicity_of_Haemophilus_influenzae_type_b_tetanus_toxoid_conjugate_presented_in_a_dual_chamber_syringe_with_diphtheria_tetanus_pertussis_and_inactivated_poliomyelitis_combination_vaccine">Safety and immunogenicity of Haemophilus influenzae type b-tetanus toxoid conjugate, presented in a dual-chamber syringe with diphtheria-tetanus-pertussis and inactivated poliomyelitis combination vaccine</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The safety and immunogenicity of combining two established vaccines, polyribosyl ribitol phosphate conjugated to tetanus toxoid (PRP-T) (ActHIB, Pasteur Mérieux Connaught, Lyon, France) and diphtheria-tetanus-whole cell pertussis and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18548992" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The safety and immunogenicity of combining two established vaccines, polyribosyl ribitol phosphate conjugated to tetanus toxoid (PRP-T) (ActHIB, Pasteur Mérieux Connaught, Lyon, France) and diphtheria-tetanus-whole cell pertussis and inactivated poliovirus vaccine (DTP-IPV) (Tetracoq, Pasteur Mérieux Connaught, Lyon, France) were evaluated using a new dual-chamber syringe delivery system. Results were compared with those obtained when the two combination vaccines were either</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18548992" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5be5134a33b3e876f73a70cebf17449b" rel="nofollow" data-download="{"attachment_id":42159878,"asset_id":18548992,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42159878/download_file?st=MTczMjQ1NzE1Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a><script data-card-contents-for-user="38584614" type="text/json">{"id":38584614,"first_name":"Luis","last_name":"Barreto","domain_name":"nrc-ca","page_name":"LuisBarreto","display_name":"Luis Barreto","profile_url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18548992 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18548992"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18548992, container: ".js-paper-rank-work_18548992", }); 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class="clearfix u-pv7x u-mb0x js-work-card work_18548993" data-work_id="18548993" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18548993/Safety_and_immunogenicity_of_two_inactivated_poliovirus_vaccines_in_combination_with_an_acellular_pertussis_vaccine_and_diphtheria_and_tetanus_toxoids_in_seventeen_to_nineteen_month_old_infants">Safety and immunogenicity of two inactivated poliovirus vaccines in combination with an acellular pertussis vaccine and diphtheria and tetanus toxoids in seventeen- to nineteen-month-old infants</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To compare the safety and immunity of an acellular pertussis vaccine containing pertussis toxoid, filamentous hemagglutinin, 69 kd protein, fimbriae 2 and 3 combined with diphtheria and tetanus toxoids given as single or separate... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18548993" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To compare the safety and immunity of an acellular pertussis vaccine containing pertussis toxoid, filamentous hemagglutinin, 69 kd protein, fimbriae 2 and 3 combined with diphtheria and tetanus toxoids given as single or separate injection with inactivated poliovirus vaccine (MRC-5-or Vero cell-derived) or live attenuated polio vaccine. A total of 425 healthy children between 17 and 19 months of age who were receiving the fourth dose of their routine immunization series were randomly allocated to receive either the acellular pertussis vaccine and oral poliovirus vaccine or one of two inactivated poliovirus vaccines as a combined injection or separate injections. Although minor adverse events were commonly reported, differences between the groups were few. Fever and decreased feeding were less common in recipients of live attenuated poliovirus vaccine than the combination vaccine containing MRC-5 cell-derived inactivated poliovirus vaccine. A significant antibody response was demonstrated in all groups against all the antigens contained in the vaccines. Antibodies against poliovirus were higher in the groups immunized with the inactivated poliovirus vaccine than the live attenuated vaccine. Anti-69 kd protein antibodies were higher in the group given the MRC-5 cell-derived inactivated poliovirus vaccine as a combined injection than in the group given the separate injection or the group immunized with the live attenuated poliovirus vaccine. The five-component acellular pertussis vaccine combined with diphtherid and tetanus toxoids is safe and immunogenic when combined with either MRC-5- or Vero cell-derived inactivated poliovirus vaccine. This will facilitate the implementation of acellular pertussis vaccine and the movement to inactivated poliovirus vaccine programs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18548993" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0a30dc74097dfd6a3ac8b47ba44f4864" rel="nofollow" data-download="{"attachment_id":42159873,"asset_id":18548993,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42159873/download_file?st=MTczMjQ1NzE1Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a><script data-card-contents-for-user="38584614" type="text/json">{"id":38584614,"first_name":"Luis","last_name":"Barreto","domain_name":"nrc-ca","page_name":"LuisBarreto","display_name":"Luis Barreto","profile_url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18548993 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18548993"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18548993, container: ".js-paper-rank-work_18548993", }); 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A total of 425 healthy children between 17 and 19 months of age who were receiving the fourth dose of their routine immunization series were randomly allocated to receive either the acellular pertussis vaccine and oral poliovirus vaccine or one of two inactivated poliovirus vaccines as a combined injection or separate injections. Although minor adverse events were commonly reported, differences between the groups were few. Fever and decreased feeding were less common in recipients of live attenuated poliovirus vaccine than the combination vaccine containing MRC-5 cell-derived inactivated poliovirus vaccine. A significant antibody response was demonstrated in all groups against all the antigens contained in the vaccines. Antibodies against poliovirus were higher in the groups immunized with the inactivated poliovirus vaccine than the live attenuated vaccine. Anti-69 kd protein antibodies were higher in the group given the MRC-5 cell-derived inactivated poliovirus vaccine as a combined injection than in the group given the separate injection or the group immunized with the live attenuated poliovirus vaccine. The five-component acellular pertussis vaccine combined with diphtherid and tetanus toxoids is safe and immunogenic when combined with either MRC-5- or Vero cell-derived inactivated poliovirus vaccine. This will facilitate the implementation of acellular pertussis vaccine and the movement to inactivated poliovirus vaccine programs.","publication":"The Journal of Pediatrics","publication_with_fallback":"The Journal of 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responsiveness after 2 Haemophilus influenzae type b conjugate vaccines</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Although immunization programs with Haemophilus influenzae type b (Hib) conjugate vaccines have dramatically reduced disease incidence, few data are available regarding the duration of protection after vaccination. We measured serum... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18548994" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Although immunization programs with Haemophilus influenzae type b (Hib) conjugate vaccines have dramatically reduced disease incidence, few data are available regarding the duration of protection after vaccination. We measured serum anti-polyribosylribitol phosphate (PRP) levels in healthy 4- to 5- year-old children previously given 4 doses of PRP-T vaccine (at 2, 4, 6, and 18 months) or 1 dose of PRP-D vaccine (at 19 months) during clinical trials to assess antibody persistence. Concurrent with other preschool immunizations, half of the children were randomly assigned to receive a PRP-T booster immunization to assess responsiveness. Among 136 subjects who were primed with PRP-D, the baseline geometric mean concentration of antibody was 0.7 microg/mL (95% CI 0.5 to 0.9). Concentrations were &amp;lt;0.15 microg/mL in 24 (17.6%) subjects. Among 212 children who were primed with PRP-T, the geometric mean concentration was 2.2 microg/mL (95% CI 1.9 to 2.5) (P &amp;lt;.001). Only 2 (0.9%) had concentrations &amp;lt;0.15 microg/mL. Four weeks after PRP-T immunization, geometric mean concentrations had increased to 98.4 and 102.0 microg/mL, respectively. Responses were strong even in those with low or undetectable preimmunization antibody levels. Spontaneous increases in antibody levels were seen in 9 (5.2%) of 172 subjects not given additional PRP-T. We concluded that among 4- to 5-year-olds, anti-PRP levels remained above 0.15 microg/mL in nearly all children after PRP-T priming and in most after PRP-D priming, and that both groups were able to respond vigorously to restimulation, consistent with persistent immune memory.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18548994" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4b00ccfedc4cbb9a646c9b1531500e10" rel="nofollow" data-download="{"attachment_id":42159876,"asset_id":18548994,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42159876/download_file?st=MTczMjQ1NzE1Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a><script data-card-contents-for-user="38584614" type="text/json">{"id":38584614,"first_name":"Luis","last_name":"Barreto","domain_name":"nrc-ca","page_name":"LuisBarreto","display_name":"Luis Barreto","profile_url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18548994 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18548994"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18548994, container: ".js-paper-rank-work_18548994", }); 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Responses were strong even in those with low or undetectable preimmunization antibody levels. Spontaneous increases in antibody levels were seen in 9 (5.2%) of 172 subjects not given additional PRP-T. We concluded that among 4- to 5-year-olds, anti-PRP levels remained above 0.15 microg/mL in nearly all children after PRP-T priming and in most after PRP-D priming, and that both groups were able to respond vigorously to restimulation, consistent with persistent immune memory.","publication":"The Journal of Pediatrics","publication_with_fallback":"The Journal of 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Barreto","profile_url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology","nofollow":false}],"publication_year":2008,"publication_year_with_fallback":2008,"paper_rank":null,"all_time_views":5,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18548996 coauthored" data-work_id="18548996" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18548996/Adult_formulation_of_a_five_component_acellular_pertussis_vaccine_combined_with_diphtheria_and_tetanus_toxoids_and_inactivated_poliovirus_vaccine_is_safe_and_immunogenic_in_adolescents_and_adults">Adult formulation of a five component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Pertussis is increasingly recognized as an important cause of cough illness in adolescents and adults. To evaluate the safety and antibody response to a single dose of an adult formulation of a five component (pertussis toxoid,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18548996" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pertussis is increasingly recognized as an important cause of cough illness in adolescents and adults. To evaluate the safety and antibody response to a single dose of an adult formulation of a five component (pertussis toxoid, filamentous hemagglutinin, pertactin, fimbriae 2 and 3) acellular pertussis vaccine (aP) combined with diphtheria and tetanus toxoids (TdaP) and inactivated poliovirus vaccine (TdaP-IPV) in adolescents and adults and to assess the response to a second dose of the acellular pertussis vaccine in a subset of the adults. The study addressed 1207 healthy participants (736 adults and 466 adolescents) recruited in five Canadian communities. In a randomized, observer-blind, controlled clinical trial, adult participants received Td followed at a separate visit by aP, TdaP followed by IPV or TdaP-IPV; adolescents received Td-IPV followed at a separate visit by aP or TdaP-IPV. A subgroup of adults was given a booster of aP 1 month after TdaP. Antibody titers measured before and 1 month after each immunization; adverse events enumerated at 24 h, 72 h and 8 to 10 days. The aP vaccine given by itself was associated with adverse events less frequently than were Td, Td-IPV, TdaP or TdaP-IPV vaccines, but reaction rates did not differ significantly among the latter products. The antibody response against Bordetella pertussis antigens was vigorous in all groups, although adults given the TdaP-IPV vaccine had lower antibody titers against filamentous hemagglutinin, pertactin, diphtheria and tetanus antibodies than those given TdaP vaccine. Similarly adolescents given TdaP-IPV had lower antibody titers against pertussis toxin, filamentous hemagglutinin, fimbriae and agglutinins than those given Td-IPV and aP alone. A second dose of acellular pertussis vaccine was not associated with increased adverse events in adults but elicited increased antibody titers over that achieved by a single dose only against pertussis toxin. This adult formulation five component aP vaccine given as TdaP-IPV is safe and immunogenic in adolescents and adults and is a candidate vaccine for adolescent and adult immunization programs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18548996" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="436dad383963f02feae13c7b11072a4d" rel="nofollow" data-download="{"attachment_id":42159869,"asset_id":18548996,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42159869/download_file?st=MTczMjQ1NzE1Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a><script data-card-contents-for-user="38584614" type="text/json">{"id":38584614,"first_name":"Luis","last_name":"Barreto","domain_name":"nrc-ca","page_name":"LuisBarreto","display_name":"Luis Barreto","profile_url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-18548996">+1</span><div class="hidden js-additional-users-18548996"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/PaulHasselback">Paul Hasselback</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-18548996'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-18548996').html(); 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js-work-card work_18549002" data-work_id="18549002" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18549002/Predicted_long_term_persistence_of_pertussis_antibodies_in_adolescents_after_an_adolescent_and_adult_formulation_combined_tetanus_diphtheria_and_5_component_acellular_pertussis_vaccine_based_on_mathematical_modeling_and_5_year_observed_data">Predicted long-term persistence of pertussis antibodies in adolescents after an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine, based on mathematical modeling and 5-year observed data</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm 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Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":795003,"name":"Linear Regression","url":"https://www.academia.edu/Documents/in/Linear_Regression"}],"publication_year":2008,"publication_year_with_fallback":2008,"paper_rank":null,"all_time_views":30,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18549003" data-work_id="18549003" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18549003/Nature_evolution_and_appraisal_of_adverse_events_and_antibody_response_associated_with_the_fifth_consecutive_dose_of_a_five_component_acellular_pertussis_based_combination_vaccine">Nature, evolution, and appraisal of adverse events and antibody response associated with the fifth consecutive dose of a five-component acellular pertussis-based combination vaccine</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We performed a randomized, controlled clinical trial to characterize the evolution of the adverse events associated with the fifth consecutive dose of an acellular pertussis vaccine, and to assess the level of discomfort associated with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18549003" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We performed a randomized, controlled clinical trial to characterize the evolution of the adverse events associated with the fifth consecutive dose of an acellular pertussis vaccine, and to assess the level of discomfort associated with the injection and the attitude of parents concerning these events. A total of 505 children who had received either four doses of acellular pertussis vaccine or whole-cell pertussis vaccine were given a fifth dose of one of the two vaccines. Adverse events were monitored by parents and collected by telephone or home visit at 4, 8, 12, 24, 48 and 72 h, and 7 and 28 days after immunization. Rates of injection site redness &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=50mm were similar in recipients of five doses of acellular pertussis vaccine (32.8%) or five doses of whole-cell pertussis vaccine (43.3%). Injection site swelling, tenderness, and decreased arm movement were all more frequent in children who received five doses of whole-cell pertussis vaccine. Antibody levels before or after immunization did not predict those children who had increased injection site reactions. The children rated the injection site reactions as significantly more severe after five consecutive doses of whole-cell vaccine. Parent satisfaction was higher after the acellular vaccine. We conclude that a fifth consecutive dose of a whole-cell pertussis vaccine is associated with high rates of tender redness and swelling at the injection site, in contrast to a fifth consecutive dose of an acellular pertussis vaccine which is associated with high rates of non-painful redness. However, parents will still need to be aware of the high rates of injection site reactions expected after a fifth dose of acellular pertussis vaccine.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18549003" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5683525b3f145bcf7d955a9a766200d6" rel="nofollow" data-download="{"attachment_id":42159870,"asset_id":18549003,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42159870/download_file?st=MTczMjQ1NzE1Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a><script data-card-contents-for-user="38584614" type="text/json">{"id":38584614,"first_name":"Luis","last_name":"Barreto","domain_name":"nrc-ca","page_name":"LuisBarreto","display_name":"Luis Barreto","profile_url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18549003 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18549003"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18549003, container: ".js-paper-rank-work_18549003", }); 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A total of 505 children who had received either four doses of acellular pertussis vaccine or whole-cell pertussis vaccine were given a fifth dose of one of the two vaccines. Adverse events were monitored by parents and collected by telephone or home visit at 4, 8, 12, 24, 48 and 72 h, and 7 and 28 days after immunization. Rates of injection site redness \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=50mm were similar in recipients of five doses of acellular pertussis vaccine (32.8%) or five doses of whole-cell pertussis vaccine (43.3%). Injection site swelling, tenderness, and decreased arm movement were all more frequent in children who received five doses of whole-cell pertussis vaccine. Antibody levels before or after immunization did not predict those children who had increased injection site reactions. The children rated the injection site reactions as significantly more severe after five consecutive doses of whole-cell vaccine. Parent satisfaction was higher after the acellular vaccine. We conclude that a fifth consecutive dose of a whole-cell pertussis vaccine is associated with high rates of tender redness and swelling at the injection site, in contrast to a fifth consecutive dose of an acellular pertussis vaccine which is associated with high rates of non-painful redness. However, parents will still need to be aware of the high rates of injection site reactions expected after a fifth dose of acellular pertussis vaccine.","publication":"Vaccine","publication_with_fallback":"Vaccine","downloadable_attachments":[{"id":42159870,"asset_id":18549003,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42159870/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42159870/s0264-410x_2803_2900173-7-libre.pdf20160205-26829-gmqx63?1454702026=\u0026response-content-disposition=attachment%3B+filename%3DNature_evolution_and_appraisal_of_advers.pdf\u0026Expires=1732460753\u0026Signature=A2wQUJ25qRnwgsXNXX4~ajNd6HnBqjbi9PQVlnDT36NCoUW5oTZq5F5TO-fkz2H3uCL-WQ--GibLncQVCaK~YUO4wxRB2AvOJu3W8VvIkv3EO64gT~mUwiW4DReXl7nN5mvnuyVxVhVcwxqSmqb8nY7mLVuCvQz3vALynGoovsuVv5GJKl-bdSiQxkwlgdKcNYzmL9ZUpwv-NFYJZeZZlG03t8fSuCKi0nFGZefbaEoZyQG1WQh101qZhXrGDd6GLFacZqUktXJIR-q5PaTAdeyeGUS4Lq6t5gFj1K5dKRPykj4LedS1b1WNlxkQpPNizwAftthcKRpnt9GxtkG8Yg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42159870/download_file?st=MTczMjQ1NzE1Myw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42159870/mini_magick20190218-7417-16lhfm0.png?1550484552"}],"downloadable_attachments_with_full_thumbnails":[{"id":42159870,"asset_id":18549003,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42159870/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42159870/s0264-410x_2803_2900173-7-libre.pdf20160205-26829-gmqx63?1454702026=\u0026response-content-disposition=attachment%3B+filename%3DNature_evolution_and_appraisal_of_advers.pdf\u0026Expires=1732460753\u0026Signature=A2wQUJ25qRnwgsXNXX4~ajNd6HnBqjbi9PQVlnDT36NCoUW5oTZq5F5TO-fkz2H3uCL-WQ--GibLncQVCaK~YUO4wxRB2AvOJu3W8VvIkv3EO64gT~mUwiW4DReXl7nN5mvnuyVxVhVcwxqSmqb8nY7mLVuCvQz3vALynGoovsuVv5GJKl-bdSiQxkwlgdKcNYzmL9ZUpwv-NFYJZeZZlG03t8fSuCKi0nFGZefbaEoZyQG1WQh101qZhXrGDd6GLFacZqUktXJIR-q5PaTAdeyeGUS4Lq6t5gFj1K5dKRPykj4LedS1b1WNlxkQpPNizwAftthcKRpnt9GxtkG8Yg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42159870/download_file?st=MTczMjQ1NzE1Myw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42159870/mini_magick20190218-7417-16lhfm0.png?1550484552"}],"has_pdf":true,"has_fulltext":true,"page_count":9,"ordered_authors":[{"id":38584614,"first_name":"Luis","last_name":"Barreto","domain_name":"nrc-ca","page_name":"LuisBarreto","display_name":"Luis Barreto","profile_url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child","nofollow":false},{"id":150847,"name":"Vaccine","url":"https://www.academia.edu/Documents/in/Vaccine","nofollow":false},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":425873,"name":"Adverse Event","url":"https://www.academia.edu/Documents/in/Adverse_Event"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine"},{"id":584597,"name":"Controlled Clinical Trial","url":"https://www.academia.edu/Documents/in/Controlled_Clinical_Trial"}],"publication_year":2003,"publication_year_with_fallback":2003,"paper_rank":null,"all_time_views":9,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18549004 coauthored" data-work_id="18549004" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18549004/Safety_and_immunogenicity_of_a_combined_five_component_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_b_conjugate_vaccine_administered_to_infants_at_two_four_and_six_months_of_age">Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus-inactivated poliomyelitis-Haemophilus b conjugate vaccine administered to infants at two, four and six months of age</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Safety, immunogenicity and lot consistency of five-component pertussis combination vaccine (CPDT-IPV//PRP-T) in infants were compared to that of whole cell pertussis combination vaccine (DPT-IPV//PRP-T), as were separate and combined... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18549004" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Safety, immunogenicity and lot consistency of five-component pertussis combination vaccine (CPDT-IPV//PRP-T) in infants were compared to that of whole cell pertussis combination vaccine (DPT-IPV//PRP-T), as were separate and combined injections of CPDT-IPV and PRP-T. No significant differences in adverse event rates were observed between lots of CPDT-IPV//PRP-T or between separate or combined injections of CPDT-IPV and PRP-T. Minor differences in antibody responses were observed between lots of component pertussis vaccine. Higher concentrations of diphtheria and tetanus antitoxins were induced by separate than by combined injection of CPDT-IPV and PRP-T, but no other differences in immunogenicity were observed. Adverse reactions were more than twice as frequent after whole cell than after component pertussis vaccines. Antibody responses to pertussis toxoid, filamentous hemagglutin and pertactin were significantly greater after component vaccines, while the response to type 3 poliovirus was higher after whole cell vaccine. No significant differences were observed for other vaccine components. CPDT-IPV//PRP-T was safe and immunogenic in infants. Antibody results were similar to those observed in a Swedish field trial that demonstrated CPDT to be 85% effective in preventing clinical pertussis.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18549004" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8f057763c01c7c216b00d7e5afc12157" rel="nofollow" data-download="{"attachment_id":42159872,"asset_id":18549004,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42159872/download_file?st=MTczMjQ1NzE1Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a><script data-card-contents-for-user="38584614" type="text/json">{"id":38584614,"first_name":"Luis","last_name":"Barreto","domain_name":"nrc-ca","page_name":"LuisBarreto","display_name":"Luis Barreto","profile_url":"https://nrc-ca.academia.edu/LuisBarreto","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-18549004">+1</span><div class="hidden js-additional-users-18549004"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/JohnThipphawong">John Thipphawong</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-18549004'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-18549004').html(); 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No significant differences in adverse event rates were observed between lots of CPDT-IPV//PRP-T or between separate or combined injections of CPDT-IPV and PRP-T. Minor differences in antibody responses were observed between lots of component pertussis vaccine. Higher concentrations of diphtheria and tetanus antitoxins were induced by separate than by combined injection of CPDT-IPV and PRP-T, but no other differences in immunogenicity were observed. Adverse reactions were more than twice as frequent after whole cell than after component pertussis vaccines. Antibody responses to pertussis toxoid, filamentous hemagglutin and pertactin were significantly greater after component vaccines, while the response to type 3 poliovirus was higher after whole cell vaccine. No significant differences were observed for other vaccine components. CPDT-IPV//PRP-T was safe and immunogenic in infants. Antibody results were similar to those observed in a Swedish field trial that demonstrated CPDT to be 85% effective in preventing clinical 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Initiative Workshop, March 26-27, 2013--Ottawa, Canada</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Novel adjuvants hold the promise for developing effective modern subunit vaccines capable of appropriately modulating the immune response against challenging diseases such as those caused by chronic and/or intracellular pathogens and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18549006" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Novel adjuvants hold the promise for developing effective modern subunit vaccines capable of appropriately modulating the immune response against challenging diseases such as those caused by chronic and/or intracellular pathogens and cancer. Over the past decade there has been intensive research into discovering new adjuvants, however, their translation into routine clinical use is lagging. To stimulate discussion and identify opportunities for networking and collaboration among various stakeholders, a Canadian Adjuvant Initiative Workshop was held in Ottawa. Sponsored by the National Research Council Canada, Canadian Institutes of Health Research and the Vaccine Industry Committee, a two day workshop was held that brought together key Canadian and international stakeholders in adjuvant research from industry, academia and government. 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