Antibody Discovery | GENEWIZ from Azenta

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href='/en/Public/Services/Next-Generation-Sequencing/Standalone-NGS-Solutions' style='color:#585F69;font-size:14px'>Sequencing Only<br></a></li><li><a href='/en/Public/Services/Next-Generation-Sequencing/Whole-Genome-Sequencing' style='color:#585F69;font-size:14px'>Whole Genome Sequencing</a></li><li><a href='/en/Public/Services/Next-Generation-Sequencing/High-Throughput-Genotyping' style='color:#585F69;font-size:14px'>CRISPR Validation</a></li><li><a href='/en/Public/Services/Next-Generation-Sequencing/Targeted-Resequencing-Panels' style='color:#585F69;font-size:14px'>Targeted Sequencing</a></li><li><a href='/en/Public/Services/Next-Generation-Sequencing/Metagenomics-Solutions' style='color:#585F69;font-size:14px'>Metagenomics </a></li><li><a href='/en/Public/Services/Next-Generation-Sequencing/Epigenomics' style='color:#585F69;font-size:14px'>Epigenomics</a></li><li><a href='/en/Public/Services/Next-Generation-Sequencing/Antibody-Discovery' 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Walking</a></li><br><li><a class='GColor' href='/en/Public/Services/Molecular-Genetics' style='color:#826ec3;font-size:17px'>PCR + Sanger Services</a></li><li><a href='/en/Public/Services/Molecular-Genetics/Bacterial-and-Fungal-Identification' style='color:#585F69;font-size:14px'>Bacterial and Fungal Identification</a></li><li><a href='/en/Public/Services/Molecular-Genetics/Mutation-Analysis' style='color:#585F69;font-size:14px'>Mutation Analysis</a></li><li><a href='/en/Public/Services/Molecular-Genetics/SNP-Genotyping' style='color:#585F69;font-size:14px'>SNP Genotyping</a></li><li><a href='/en/Public/Services/Molecular-Genetics/PCR-Plus-Sequencing-CRISPR-Analysis-Package' style='color:#585F69;font-size:14px'>PCR Plus Sequencing CRISPR Analysis Package</a></li><li><a href='/en/Public/Services/Molecular-Genetics/cDNA-Verification' style='color:#585F69;font-size:14px'>Confirmatory Sequencing & Cell Bank Characterization</a></li><li><a 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href='/en/Public/Services/Gene-Synthesis/Antibody-DNA-Synthesis' style='color:#585F69;font-size:14px'>Antibody Synthesis</a></li><li><a href='/en/Public/Services/Gene-Synthesis/AAV-Plasmid-Synthesis' style='color:#585F69;font-size:14px'>AAV Plasmid Synthesis</a></li><li><a href='/en/Public/Services/Gene-Synthesis/Gene-Fragments' style='color:#585F69;font-size:14px'>Gene Fragments</a></li><li><a href='/en/Public/Services/Gene-Synthesis/CRISPR-Construct-Synthesis' style='color:#585F69;font-size:14px'>CRISPR Construct Synthesis</a></li><li><a href='/en/Public/Services/Gene-Synthesis/Synthetic-DNA-Libraries' style='color:#585F69;font-size:14px'>Synthetic DNA Libraries</a></li><li><a href='/en/Public/Services/Gene-Synthesis/Single-Stranded-DNA-Synthesis' style='color:#585F69;font-size:14px'>ssDNA Synthesis</a></li><li><a href='/en/Public/Services/Gene-Synthesis/DNA-Cloning' style='color:#585F69;font-size:14px'>DNA Cloning</a></li><li><a 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Whole Genome Sequencing</a></li><li><a href='/en/Public/Services/Clinical-Services/Regulatory' style='color:#585F69;font-size:14px'>GLP-Compliant Overview</a></li><li><a href='/en/Public/Services/Clinical-Services/GLP-compliant-Confirmatory-Sequencing' style='color:#585F69;font-size:14px'>GLP Confirmatory Sequencing</a></li><li><a href='/en/Public/Services/Clinical-Services/GLP-compliant-SNP-Mutation-Analysis' style='color:#585F69;font-size:14px'>GLP SNP Mutation Analysis</a></li><li><a href='/en/Public/Services/Clinical-Services/GLP-compliant-Plasmid-Prep' style='color:#585F69;font-size:14px'>GLP Plasmid Prep</a></li><li><a href='/en/Public/Services/Clinical-Services/Nucleic-Acid-Extraction' style='color:#585F69;font-size:14px'>GLP Nucleic Acid Extraction</a></li><li><a href='/en/Public/Services/Clinical-Services/Biofluid-Processing-Overview' style='color:#585F69;font-size:14px'>Biofluid Processing</a></li><li><a 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} .ngs-content-box button { border: none; border-radius: 4px; background: #826ec3; padding: 10px 20px; color: #fff; font-size: 17px; letter-spacing: 1px; } .ngs-content-box button:hover { background: #6965a1; } @media only screen and (max-width: 768px) { .headline-center { padding-top: 0; } .ngs-new-container { text-align: center; margin-top: 0; } .ngs-new-content { width: 90%; margin: 0 auto; } .ngs-new-content { display: inline-block; } #ngs-content-box-right, #ngs-content-box-left { width: 100%; text-align: center; } #ngs-content-box-right { margin-top: 20px; } } @media only screen and (max-width: 1170px) { .ngs-new-content { width: 90%; margin: 0 auto; } .ngs-content-box img { width: 350px; } } </style> <div class="ngs-new-container"> <div class="ngs-new-content"> <div class="ngs-content-box" id="ngs-content-box-left"> <h1>ANTIBODY DISCOVERY</h1> <div> </div> <p>Our Precision Antibody Discovery service rapidly identifies and expresses antibody sequences with a broad affinity range for your target and the most promising biophysical profiles for commercialization. Utilizing next generation sequencing (NGS) of your <em>in vivo</em> samples (i.e., B cells, PBMCs) or <em>in vitro</em> libraries (i.e., phage display) and the power of machine learning with our novel bioinformatic platform, AbXtract™, powered by OpenEye and developed by Specifica, this end-to-end workflow enables high-throughput screening of your library to generate 5 – 50x more antibody leads than traditional low-throughput approaches. This results in more functionally diverse leads, even including clonotypes and rare clones, improving antibody program success. </p> <div> </div> <p> </p> <a rel="noopener noreferrer" rel="noopener noreferrer" href="https://web.genewiz.com/precision-antibody-quote" target="_blank"><button>Find Your Antibodies</button></a> </div> <div class="ngs-content-box" id="ngs-content-box-right"> <a rel="noopener noreferrer" rel="noopener noreferrer" href="https://hubs.ly/Q02JnshZ0" target="_blank"><img alt="" src="/-/media/77007-D-0724-Workshops_Sept19_Right.ashx?la=en&hash=55A591FE329981CF8CBFE9F423B3B26CB110DE5A" /></a> </div> </div> </div> </div> <div class="headline-center Rich-Text-Edit-Area"> <div class="container margin-bottom-40"> <h2>ANTIBODY DISCOVERY SERVICE</h2> <p style="text-align: left;">Selecting the right antibody leads with favorable development characteristics the first time around is essential for the success of your antibody program. Combining NGS, machine learning bioinformatics, and recombinant antibody production into a singular workflow, GENEWIZ Precision Antibody Discovery empowers you to rapidly and efficiently discover candidates that you would otherwise miss with traditional screening technologies and processes.</p> </div> </div> <script type="text/javascript" src="/assets/plugins/counter/jquery.counterup.min.js"></script> <script language="javascript" type="text/javascript"> jQuery(document).ready(function ($) { $("div[id^=Desc]").find("img").addClass("img-responsive"); }); </script> <div class='Component-Frame pull-center Two-Column-Text-Image-LR-Layout-v1 Component-BackGround-Default pure-template divider margin-top-50 margin-bottom-30 padding-top-10 padding-bottom-10'> <div class="container"> <div class="row"> <div class="col-md-7"> <h1 class="title-v2"></h1> <p><strong>Uncover more leads</strong>: Increase the number of clonotype leads by 5–10x compared to random colony screening and produce a set of recombinant antibodies ready for experimentation</p> <p><strong>Achieve greater library diversity</strong>: Leveraging NGS, explore the complete antibody repertoire, including rare clones, which are typically missed using low-throughput methods</p> <p><strong>Decrease sequence liabilities</strong>: NGS & computational processing help to reduce sequence liabilities and improve efficiency of downstream therapeutic development, resulting in prioritized leads based on favored developability and biophysical profiles</p> <p><strong>Discover antibodies faster</strong>: Computational processing of NGS datasets coupled with recombinant production provides a faster and more efficient screening process and production of high affinity antibody leads</p> <br> </div> <div class="col-md-5" id="DescImg"> <img src="/-/media/13071D-Precision-Antibody-Logos3x.ashx?h=1201&la=en&w=1801&hash=2A9D16648DF4C5D285DBB61D782315EAD57E6896" alt="Building" width="1801" height="1201" title="Precision Antibody Logos" /> </div> </div> </div> </div> <div class="headline-center Rich-Text-Edit-Area"> <style type="text/css"> .protocol { width: 1170px; display: inline-block; text-align: center; } .protocol img { width: 98%; height: auto; display: block; margin-left: auto; margin-right: auto; } @media screen and (max-width: 1170px) { .protocol { width: auto; } } </style> <div class="protocol"> <h2>ANTIBODY DISCOVERY WORKFLOW</h2> <p> </p> <p><img alt="" src="/-/media/Precision-Antibody-Workflow.ashx?w=1170px&la=en&hash=6BF1ADE7CBF941840670BB7107D65EA4B38BE2B4" width="1170px" /></p> </div> <br /> <br /> </div> <script language="javascript" type="text/javascript"> jQuery(document).ready(function ($) { $(".SingleIcon").find("img").addClass("img-responsive center-block"); }); </script> <div class="process-v1 icon-nav Component-BackGround-Default margin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10"> <div class="container"> <div class="headline-center"> <h2>BENEFITS OF ANTIBODY DISCOVERY USING ABXTRACT</h2> <p></p> </div> <ul class="list-unstyled row "> <li class='col-sm-3'> <div class='SingleIcon headline-center Component-BackGround-Defaultmargin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10'> <div class="row"> <img src="/-/media/13071-D_Precision-Antibody-Disc_GWZ-Graphic1.ashx?h=110&la=en&w=210&hash=4123B003ABE5C126CB380519200FA1E77045745B" alt="Building" width="210" height="110" title="Annotation" /> </div> <div class="row"> <h3>1. Annotation</h3> </div> <div class="row"> Annotate CDRs and framework regions of interest (ROI) </div> </div> </li>  <li class='col-sm-3'> <div class='SingleIcon headline-center Component-BackGround-Defaultmargin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10'> <div class="row"> <img src="/-/media/13071-D_Precision-Antibody-Disc_GWZ-Graphic2.ashx?h=110&la=en&w=210&hash=44C76F6F3D4D5DF51441A7CA972A3CA764D0CC7B" alt="Building" width="210" height="110" title="Abundance" /> </div> <div class="row"> <h3>2. Abundance / Enrichment</h3> </div> <div class="row"> Enrichment based on your ROI </div> </div> </li>  <li class='col-sm-3'> <div class='SingleIcon headline-center Component-BackGround-Defaultmargin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10'> <div class="row"> <img src="/-/media/13071-D_Precision-Antibody-Disc_GWZ-Graphic3.ashx?h=110&la=en&w=210&hash=4DDA1D15B13294D32E1D498190C8ADF6B72BBA8A" alt="Building" width="210" height="110" title="Clustering" /> </div> <div class="row"> <h3>3. Clustering</h3> </div> <div class="row"> Maximize sequence diversity by clustering based on ROI </div> </div> </li>  <li class='col-sm-3'> <div class='SingleIcon headline-center Component-BackGround-Defaultmargin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10'> <div class="row"> <img src="/-/media/13071-D_Precision-Antibody-Disc_GWZ-Graphic4.ashx?h=110&la=en&w=210&hash=70D0B602ABF0C37D52A2B36C24FCA55C17B0577A" alt="Building" width="210" height="110" title="Prioritization" /> </div> <div class="row"> <h3>4. Prioritization</h3> </div> <div class="row"> Quantify sequence-based biophysical liabilities and prioritize favorable leads providing immediate gene synthesis-ready output </div> </div> </li>  </ul> <div class="row headline-center"> </div> </div> </div> <div class="headline-center Rich-Text-Edit-Area"> <div class="container"> <h2>DELIVERABLES</h2> <p style="text-align: center;"><strong>Standard Deliverables</strong></p> <p style="text-align: center;"> • NGS FASTQ files<br /> • AbXtract report<br /> • Expressed antibodies (mL to L expression scales available)<br /> • Antibody QC report including SDS-PAGE analysis</p> <p> </p> </div> </div> <script language="javascript" type="text/javascript"> jQuery(document).ready(function ($) { $(".SingleIcon").find("img").addClass("img-responsive center-block"); }); </script> <div class="process-v1 icon-nav Component-BackGround-Gray margin-top-0 margin-bottom-0 padding-top-10 padding-bottom-0"> <div class="container"> <div class="headline-center"> <h2>TECHNICAL RESOURCES</h2> <p></p> </div> <ul class="list-unstyled row "> <li class='col-sm-4 col-centered'> <a href='https://www.genewiz.com/en/Public/Resources/Sample-Submission-Guidelines/Next-Generation-Sequencing-Sample-Submission-Guidelines' target=''> <div class='SingleIcon headline-center Component-BackGround-Default margin-top-0 margin-bottom-0 padding-top-10 padding-bottom-0'> <div class="row"> <img src="/-/media/Images/Prepare-Samples_210x110_purple.ashx?h=111&la=en&w=211&hash=8626211B8F77D0FB6757AF5D5E5A2960B52652D6" alt="Building" width="211" height="111" /> </div> <div class="row"> <h3>Sample Submission Guidelines</h3> </div> <div class="row"> </div> </div> </a> </li>  <li class='col-sm-4 col-centered'> <a href='https://web.genewiz.com/precision-antibody-discovery-faq' target='blank'> <div class='SingleIcon headline-center Component-BackGround-Default margin-top-0 margin-bottom-0 padding-top-10 padding-bottom-0'> <div class="row"> <img src="/-/media/Images/FAQ_210x110_purple.ashx?h=111&la=en&w=211&hash=3E72FE67CF61B960C891CE902CD430B183BB8BF7" alt="Building" width="211" height="111" /> </div> <div class="row"> <h3>Frequently Asked Questions</h3> </div> <div class="row"> </div> </div> </a> </li>  </ul> <div class="row headline-center"> </div> </div> </div><div class="headline-center Rich-Text-Edit-Area"> <style type="text/css"> body { margin: 0; } .tech-resources-container { width: 1170px; margin: 0 auto; padding: 20px; } .tech-resources-container h2 { text-align: center; border-bottom: none; } .tech-resource { display: flex; align-items: center; flex-direction: row; margin-bottom: 35px; } .resource { flex-grow: 1; } .resource-right h3, .resource-right p { width: 90%; margin: 0 auto; border-bottom: none; text-align: left; } .resource button { padding: 5px 15px; border: none; border-radius: 4px; background: #826ec3; color: #fff; font-size: 15px; font-weight: lighter; letter-spacing: 1px; margin-top: 15px; -webkit-transition: ease-in-out 0.2s; -moz-transition: ease-in-out 0.2s; -o-transition: ease-in-out 0.2s; transition: ease-in-out 0.2s; } .resource button:hover { background: #6959a1; } @media only screen and (max-width: 800px) { .tech-resource { flex-direction: column; text-align: center; } .resource-right h3, .resource-right p { text-align: center; } } @media only screen and (max-width: 1170px) { .tech-resources-container { width: 80%; margin: 0 auto; } } </style> <div style="width: 100%; background-color: #f0f0f0; padding: 20px; margin: 0;margin-top: -20px;"> <div class="tech-resources-container"> <div class="tech-resource"> <div class="resource resource-left"> <img alt="" src="/-/media/rAB-Application-Note-Thumbnail.ashx?la=en&hash=ABD1E9B71BDD69A5EFA233AA96DE8809A3166D86" /> </div> <div class="resource resource-right"> <h3>Application Note | Accelerating Recombinant Antibody Production</h3> <p>Recombinant antibody production is a cornerstone of modern biotechnology and research, but it faces the significant challenge of achieving high yields. In this application note, discover how to enhance expression efficiency while reducing production times with an optimized vector backbone workflow. <br /> <a href="https://hubs.ly/Q02PhGFp0" target="_blank"> <button>Download Now</button> </a> </p> </div> </div> </div> </div> </div> <div class="headline-center Rich-Text-Edit-Area"> <div class="container"> <div class="row"> <h2>NGS PLATFORMS</h2> <p>For information on our NGS platforms as well as recommended configurations of your projects, please visit the <a href="https://www.genewiz.com/en/Public/Resources/NGS-Platforms">NGS Platforms</a> page. <em>Azenta does not guarantee data output or quality for sequencing-only projects</em>.</p> </div> <div class="row row-centered margin-top-30"> <div class="col-sm-3 col-centered"><a href="#Illumina"><img alt="Illumina" src="/-/media/hires-illumina-logo-rgb_new.ashx?w=200&la=en&hash=2DE7778E5877DA9F3D063A9FAF021DA575ECF223" style="width: 200px;" /></a> </div> <div class="col-sm-3 col-centered"><a href="#PacBio"><img alt="PacBio" src="/-/media/PacBio-CSP_logo.ashx?w=200&la=en&hash=1568DC13B370C032463997ED7BC5591C1FECF672" style="width: 200px;" /></a> </div> <div class="col-sm-3 col-centered"><a href="#10x"><img alt="10x Genomics" src="/-/media/10x-Genomics-CSP_logo.ashx?w=200&la=en&hash=2584354CF0810D46E980E04C8C03461D332EE516" style="width: 200px;" /></a> </div> <div class="col-sm-3 col-centered"><a href="#Nanostring"><img alt="NanoString" src="/-/media/Images/Resources/NGS-Platforms-and-Specifications/NanoString_resized_logo.ashx?w=200&la=en&hash=A22CDFCF6A16A9884C633E8C2EF98B468325D130" style="width: 200px;" /></a> </div> </div> <div class="row row-centered margin-top-30"> <div class="col-sm-3 col-centered"><a href="#Oxford-Nanopore"><img alt="Nanopore" src="/-/media/ONT_ServiceCertified_logo-cut.ashx?w=200&la=en&hash=4140BDC9974099FF45B0BBB29FCC746FEDCFBCC7" style="width: 200px;" /></a> </div> <div class="col-sm-3 col-centered"><a href="#Olink"><img alt="Olink" src="/-/media/Olink-Certified-Service-Provider-cut.ashx?w=200&la=en&hash=A8C78860807705F8B01299DE5A728848734F53EF" style="width: 200px;" /></a> </div> </div> <br /> <br /> </div> </div> <script language="javascript" type="text/javascript"> jQuery(document).ready(function ($) { $(".SingleIcon").find("img").addClass("img-responsive center-block"); }); </script> <div class="process-v1 icon-nav Component-BackGround-Default margin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10 "> <div class=" container"> <div class="headline-center"> <h2>RELATED SERVICES</h2> <p></p> </div> <ul class="list-unstyled row "> <li class='col-sm-4'> <a href='https://www.genewiz.com/en/Public/Services/Next-Generation-Sequencing/Immunogenomics' target=''> <div class='SingleIcon headline-center Component-BackGround-Default margin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10'> <div class="row"> <img src="/-/media/Antibody-Purple_210x110.ashx?h=110&la=en&w=210&hash=1A959346E6B7E46D3CD8572336AF35E84B28287C" alt="Building" width="210" height="110" title="Antibody Icon" /> </div> <div class="row"> <h3>Immunogenomics</h3> </div> <div class="row"> </div> </div> </a> </li>  <li class='col-sm-4'> <a href='https://www.genewiz.com/en/Public/Services/Gene-Synthesis/Antibody-DNA-Synthesis' target=''> <div class='SingleIcon headline-center Component-BackGround-Default margin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10'> <div class="row"> <img src="/-/media/Icon_210x110_Recombinant-Antibody-Production.ashx?h=111&la=en&w=211&hash=48145CC68F9EE3C5F01EC054BE408BBA925A3B48" alt="Building" width="211" height="111" title="Recombinant Antibody Production Icon" /> </div> <div class="row"> <h3>Antibody DNA Synthesis</h3> </div> <div class="row"> </div> </div> </a> </li>  <li class='col-sm-4'> <a href='https://www.genewiz.com/en/Public/Services/Gene-Synthesis/Recombinant-Antibody-Production' target=''> <div class='SingleIcon headline-center Component-BackGround-Default margin-top-0 margin-bottom-30 padding-top-10 padding-bottom-10'> <div class="row"> <img src="/-/media/Antibody-Purple_210x110.ashx?h=110&la=en&w=210&hash=1A959346E6B7E46D3CD8572336AF35E84B28287C" alt="Building" width="210" height="110" title="Antibody Icon" /> </div> <div class="row"> <h3>Antibody Production</h3> </div> <div class="row"> </div> </div> </a> </li>  </ul> <div class="row headline-center"> </div> </div> </div> <div class="process-v1 How-To-Order Component-BackGround-Gray margin-top-0 margin-bottom-0 padding-top-10 padding-bottom-10 "> <div class=" container"> <div class="headline-center"> <div class="row"> <h2>HOW TO ORDER</h2> </div> <div class="row"> </div> </div> <ul class="list-inline row process-in process-border-3 col-md-offset-2 col-sm-offset-1 col-xs-offset-0"> <li class="col-sm-3"> <div class="process-icon"> <i class="rounded-x dot-active"></i> </div> <a 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