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Fibroblast growth factor 1 - Wikipedia
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class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">This article is about fibroblast growth factor-1. For the internal ribosome entry site, see <a href="/wiki/FGF-1_internal_ribosome_entry_site_(IRES)" title="FGF-1 internal ribosome entry site (IRES)">FGF-1 internal ribosome entry site (IRES)</a>.</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">FGF1</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_FGF1_PDB_1afc.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Protein_FGF1_PDB_1afc.png/250px-Protein_FGF1_PDB_1afc.png" decoding="async" width="250" height="242" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Protein_FGF1_PDB_1afc.png/375px-Protein_FGF1_PDB_1afc.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Protein_FGF1_PDB_1afc.png/500px-Protein_FGF1_PDB_1afc.png 2x" data-file-width="1032" data-file-height="1000" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P61148%20or%20P05230%20or%20C9JUP6">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P61148,P05230,C9JUP6">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4QO3">4QO3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1AXM">1AXM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DJS">1DJS</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DZC">1DZC</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DZD">1DZD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1E0O">1E0O</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1EVT">1EVT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1HKN">1HKN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JQZ">1JQZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JT3">1JT3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JT4">1JT4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JT5">1JT5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JT7">1JT7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JTC">1JTC</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JY0">1JY0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1K5U">1K5U</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1K5V">1K5V</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1M16">1M16</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1NZK">1NZK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1P63">1P63</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1PZZ">1PZZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1Q03">1Q03</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1Q04">1Q04</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1RG8">1RG8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1RML">1RML</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1RY7">1RY7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1YTO">1YTO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1Z2V">1Z2V</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1Z4S">1Z4S</a>, <a rel="nofollow" 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href="https://www.rcsb.org/structure/3CRI">3CRI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3CU1">3CU1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FGM">3FGM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJ8">3FJ8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJ9">3FJ9</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJA">3FJA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJB">3FJB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJC">3FJC</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJD">3FJD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJE">3FJE</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJF">3FJF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJH">3FJH</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJI">3FJI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJJ">3FJJ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3FJK">3FJK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3HOM">3HOM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3JUT">3JUT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3K1X">3K1X</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3O3Q">3O3Q</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3OJ2">3OJ2</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3OJM">3OJM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3OJV">3OJV</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3UD7">3UD7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3UD8">3UD8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3UD9">3UD9</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3UDA">3UDA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4J23">4J23</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4Q91">4Q91</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4Q9G">4Q9G</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4Q9P">4Q9P</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4QAL">4QAL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4QBC">4QBC</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4QBV">4QBV</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4QC4">4QC4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4XKI">4XKI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4YOL">4YOL</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/3665">FGF1</a></span>, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/131220">131220</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:95515">95515</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=625">625</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=FGF1">FGF1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000113578">FGF1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (human)"><img alt="Chromosome 5 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/450px-Ideogram_human_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/600px-Ideogram_human_chromosome_5.svg.png 2x" data-file-width="500" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_5_(human)" class="mw-redirect" title="Chromosome 5 (human)">Chromosome 5 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_5_ideogram.svg" class="mw-file-description" title="Chromosome 5 (human)"><img alt="Chromosome 5 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/300px-Human_chromosome_5_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/450px-Human_chromosome_5_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/600px-Human_chromosome_5_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 225.7174901513px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for FGF1"><img alt="Genomic location for FGF1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 231.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for FGF1"><img alt="Genomic location for FGF1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">5q31.3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">142,592,178 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">142,698,070 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_18.svg" class="mw-file-description" title="Chromosome 18 (mouse)"><img alt="Chromosome 18 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/260px-Ideogram_house_mouse_chromosome_18.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/390px-Ideogram_house_mouse_chromosome_18.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/520px-Ideogram_house_mouse_chromosome_18.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 18 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_18.svg" class="mw-file-description" title="Chromosome 18 (mouse)"><img alt="Chromosome 18 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/86/Ideogram_of_house_mouse_chromosome_18.svg/300px-Ideogram_of_house_mouse_chromosome_18.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/86/Ideogram_of_house_mouse_chromosome_18.svg/450px-Ideogram_of_house_mouse_chromosome_18.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/86/Ideogram_of_house_mouse_chromosome_18.svg/600px-Ideogram_of_house_mouse_chromosome_18.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 121.12588838255px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for FGF1"><img alt="Genomic location for FGF1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 127.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for FGF1"><img alt="Genomic location for FGF1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">18 B3|18 20.74 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">38,971,726 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">39,062,525 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000113578">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">glomerulus</li><br /><li style="line-height: 137%;">metanephric glomerulus</li><br /><li style="line-height: 137%;">inferior ganglion of vagus nerve</li><br /><li style="line-height: 137%;">corpus callosum</li><br /><li style="line-height: 137%;">optic nerve</li><br /><li style="line-height: 137%;">external globus pallidus</li><br /><li style="line-height: 137%;">internal globus pallidus</li><br /><li style="line-height: 137%;">medulla oblongata</li><br /><li style="line-height: 137%;">inferior olivary nucleus</li><br /><li style="line-height: 137%;">olfactory bulb</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000036585">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">deep cerebellar nuclei</li><br /><li style="line-height: 137%;">pontine nuclei</li><br /><li style="line-height: 137%;">medial vestibular nucleus</li><br /><li style="line-height: 137%;">habenula</li><br /><li style="line-height: 137%;">facial motor nucleus</li><br /><li style="line-height: 137%;">dorsal tegmental nucleus</li><br /><li style="line-height: 137%;">anterior horn of spinal cord</li><br /><li style="line-height: 137%;">right lung</li><br /><li style="line-height: 137%;">myocardium of ventricle</li><br /><li style="line-height: 137%;">right ventricle</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000113578">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_FGF1_208240_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a0/PBB_GE_FGF1_208240_s_at_fs.png/250px-PBB_GE_FGF1_208240_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a0/PBB_GE_FGF1_208240_s_at_fs.png/375px-PBB_GE_FGF1_208240_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a0/PBB_GE_FGF1_208240_s_at_fs.png/500px-PBB_GE_FGF1_208240_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_FGF1_205117_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0c/PBB_GE_FGF1_205117_at_fs.png/250px-PBB_GE_FGF1_205117_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0c/PBB_GE_FGF1_205117_at_fs.png/375px-PBB_GE_FGF1_205117_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0c/PBB_GE_FGF1_205117_at_fs.png/500px-PBB_GE_FGF1_205117_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/2246/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044548">S100 protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008083">growth factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004713">protein tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046934">phosphatidylinositol-4,5-bisphosphate 3-kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005104">fibroblast growth factor receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005178">integrin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016303">1-phosphatidylinositol-3-kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008201">heparin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030544">Hsp70 protein binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005938">cell cortex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005730">nucleolus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031012">extracellular matrix</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034605">cellular response to heat</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001934">positive regulation of protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043406">positive regulation of MAP kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001759">organ induction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030324">lung development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050679">positive regulation of epithelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009653">anatomical structure morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1902533">positive regulation of intracellular signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060681">branch elongation involved in ureteric bud branching</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045766">positive regulation of angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000165">MAPK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007275">multicellular organism development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072163">mesonephric epithelium development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001525">angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000544">regulation of endothelial cell chemotaxis to fibroblast growth factor</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045542">positive regulation of cholesterol biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008283">cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051781">positive regulation of cell division</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046854">phosphatidylinositol phosphate biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0018108">peptidyl-tyrosine phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1903672">positive regulation of sprouting angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008543">fibroblast growth factor receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0036092">phosphatidylinositol-3-phosphate biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901509">regulation of endothelial tube morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030335">positive regulation of cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010595">positive regulation of endothelial cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032148">activation of protein kinase B activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010469">regulation of signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051897">positive regulation of protein kinase B signaling</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=2246&rn=1">2246</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=14164&rn=1">14164</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000113578;db=core">ENSG00000113578</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000036585;db=core">ENSMUSG00000036585</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P05230">P05230</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P61148">P61148</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000800">NM_000800</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144892">NM_001144892</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144934">NM_001144934</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144935">NM_001144935</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001257205">NM_001257205</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001257206">NM_001257206</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001257207">NM_001257207</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001257208">NM_001257208</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001257209">NM_001257209</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001257210">NM_001257210</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001257211">NM_001257211</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001257212">NM_001257212</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_033136">NM_033136</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_033137">NM_033137</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354955">NM_001354955</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354956">NM_001354956</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354957">NM_001354957</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354958">NM_001354958</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354959">NM_001354959</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354961">NM_001354961</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354963">NM_001354963</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354964">NM_001354964</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354951">NM_001354951</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354952">NM_001354952</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354953">NM_001354953</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354954">NM_001354954</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001354962">NM_001354962</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_010197">NM_010197</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000791">NP_000791</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138364">NP_001138364</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138406">NP_001138406</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138407">NP_001138407</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001244134">NP_001244134</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001244135">NP_001244135</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001244136">NP_001244136</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001244137">NP_001244137</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001244138">NP_001244138</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001244139">NP_001244139</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001244140">NP_001244140</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001244141">NP_001244141</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_149127">NP_149127</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_149128">NP_149128</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341884">NP_001341884</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341885">NP_001341885</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341886">NP_001341886</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341887">NP_001341887</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341888">NP_001341888</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341890">NP_001341890</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341892">NP_001341892</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341893">NP_001341893</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341880">NP_001341880</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341881">NP_001341881</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341882">NP_001341882</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341883">NP_001341883</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001341891">NP_001341891</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_034327">NP_034327</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr5:142592178-142698070">Chr 5: 142.59 – 142.7 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr18:38971726-39062525">Chr 18: 38.97 – 39.06 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14889334" class="extiw" title="d:Q14889334">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14889335" class="extiw" title="d:Q14889335">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Fibroblast growth factor 1</b> <b>(FGF-1)</b> also known as <b>acidic fibroblast growth factor</b> (<b>aFGF</b>), is a <a href="/wiki/Growth_factor" title="Growth factor">growth factor</a> and <a href="/wiki/Signaling_protein" class="mw-redirect" title="Signaling protein">signaling protein</a> encoded by the <i>FGF1</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid1697263_5-0" class="reference"><a href="#cite_note-pmid1697263-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid3523756_6-0" class="reference"><a href="#cite_note-pmid3523756-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-<a href="/wiki/Glycosylated" class="mw-redirect" title="Glycosylated">glycosylated</a> 17-18 kDa protein. <a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">Fibroblast growth factor</a> protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and <a href="/wiki/ECGF1" class="mw-redirect" title="ECGF1">Endothelial cell growth factor-1</a>.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a <a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">family of FGF</a> proteins. </p><p>FGF-1 has no definitive signal sequence and thus is not secreted through classical pathways, but it does appear to form a disulfide linked dimer inside cells that associate with a complex of proteins at the cell membrane (including <a href="/wiki/S100A13" title="S100A13">S100A13</a> and <a href="/wiki/Synaptotagmin_1" class="mw-redirect" title="Synaptotagmin 1">Syt1</a>) which then help flip it through the membrane to the exterior of the cell.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Prudovsky&Maciag_9-0" class="reference"><a href="#cite_note-Prudovsky&Maciag-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Once in the reducing conditions of the surrounding tissue, the dimer dissociates into <a href="/wiki/Monomer" title="Monomer">monomeric</a> FGF1 that can enter systemic circulation or be sequestered in tissues binding to <a href="/wiki/Heparan_sulfate_proteoglycan" class="mw-redirect" title="Heparan sulfate proteoglycan">heparan sulfate proteoglycans</a> of the <a href="/wiki/Extracellular_matrix" title="Extracellular matrix">extracellular matrix</a>. FGF1 can then bind to and exert its effects via specific <a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">fibroblast growth factor receptor (FGFR)</a> proteins which themselves constitute a family of closely related molecules.<sup id="cite_ref-pmid_24780002_10-0" class="reference"><a href="#cite_note-pmid_24780002-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>In addition to its extracellular activity, FGF1 can also function intracellularly. The protein has a <a href="/wiki/Nuclear_localization_sequence" title="Nuclear localization sequence">nuclear localization sequence</a> (NLS) but the route that FGF1 takes to get to the nucleus is unclear and it appears that some sort of cell surface receptor binding is necessary, followed by its internalization and translocation to the nucleus whereupon it can interact with nuclear isoforms of FGFRs.<sup id="cite_ref-pmid_24780002_10-1" class="reference"><a href="#cite_note-pmid_24780002-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> This is different from <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">FGF2</a> which also can activate nuclear FGFRs but has splicing variants of the protein that never leave the cell and go directly to the nucleus.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (February 2024)">citation needed</span></a></i>]</sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_1&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>FGF family members possess broad <a href="/wiki/Mitogenic" class="mw-redirect" title="Mitogenic">mitogenic</a> and cell survival activities, and are involved in a variety of biological processes, including <a href="/wiki/Embryonic_development" class="mw-redirect" title="Embryonic development">embryonic development</a>, <a href="/wiki/Cell_growth" title="Cell growth">cell growth</a>, <a href="/wiki/Morphogenesis" title="Morphogenesis">morphogenesis</a>, <a href="/wiki/Tissue_repair" class="mw-redirect" title="Tissue repair">tissue repair</a>, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of <a href="/wiki/Mesoderm" title="Mesoderm">mesoderm</a>- and neuroectoderm-derived cells in vitro, thus is thought to be involved in <a href="/wiki/Organogenesis" title="Organogenesis">organogenesis</a>. Three alternatively spliced variants encoding different isoforms have been described.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>FGF1 is multifunctional with many reported effects. For one example, in mice with diet-induced diabetes that is an experimental equivalent of type 2 diabetes in humans, a single injection of the FGF1 protein is enough to restore blood sugar levels to a healthy range for > 2 days.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_1&action=edit&section=2" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>FGF1 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/CSNK2A2" title="CSNK2A2">CSNK2A2</a><sup id="cite_ref-pmid12145206_13-0" class="reference"><a href="#cite_note-pmid12145206-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CSNK2B" title="CSNK2B">CSNK2B</a><sup id="cite_ref-pmid12145206_13-1" class="reference"><a href="#cite_note-pmid12145206-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Casein_kinase_2,_alpha_1" title="Casein kinase 2, alpha 1">CSNK2A1</a><sup id="cite_ref-pmid12145206_13-2" class="reference"><a href="#cite_note-pmid12145206-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/FIBP" title="FIBP">FIBP</a><sup id="cite_ref-pmid9806903_14-0" class="reference"><a href="#cite_note-pmid9806903-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a><sup id="cite_ref-pmid11030354_15-0" class="reference"><a href="#cite_note-pmid11030354-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8576175_16-0" class="reference"><a href="#cite_note-pmid8576175-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">FGFR2</a><sup id="cite_ref-pmid8576175_16-1" class="reference"><a href="#cite_note-pmid8576175-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10618369_17-0" class="reference"><a href="#cite_note-pmid10618369-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11069186_18-0" class="reference"><a href="#cite_note-pmid11069186-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a><sup id="cite_ref-pmid8576175_16-2" class="reference"><a href="#cite_note-pmid8576175-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10574949_19-0" class="reference"><a href="#cite_note-pmid10574949-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a><sup id="cite_ref-pmid10736564_20-0" class="reference"><a href="#cite_note-pmid10736564-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10336501_21-0" class="reference"><a href="#cite_note-pmid10336501-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/HSPA9" title="HSPA9">HSPA9</a><sup id="cite_ref-pmid10510314_22-0" class="reference"><a href="#cite_note-pmid10510314-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/S100A13" title="S100A13">S100A13</a><sup id="cite_ref-Prudovsky&Maciag_9-1" class="reference"><a href="#cite_note-Prudovsky&Maciag-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9712836_23-0" class="reference"><a href="#cite_note-pmid9712836-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11432880_24-0" class="reference"><a href="#cite_note-pmid11432880-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Synaptotagmin_1" class="mw-redirect" title="Synaptotagmin 1">Synaptotagmin 1 (SYT1)</a><sup id="cite_ref-Prudovsky&Maciag_9-2" class="reference"><a href="#cite_note-Prudovsky&Maciag-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9712836_23-1" class="reference"><a href="#cite_note-pmid9712836-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_1&action=edit&section=3" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">Fibroblast growth factor</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_1&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000113578">GRCh38: Ensembl release 89: ENSG00000113578</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000036585">GRCm38: Ensembl release 89: ENSMUSG00000036585</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=2246">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D2246&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+1" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=14164">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D14164&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+1" class="Z3988"></span></span> </li> <li id="cite_note-pmid1697263-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1697263_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDionneCrumleyBellotKaplow1990" class="citation journal cs1">Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (September 1990). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551973">"Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors"</a>. <i>The EMBO Journal</i>. <b>9</b> (9): 2685–92. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fj.1460-2075.1990.tb07454.x">10.1002/j.1460-2075.1990.tb07454.x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551973">551973</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1697263">1697263</a>.</cite><span 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=S100A13+is+involved+in+the+regulation+of+fibroblast+growth+factor-1+and+p40+synaptotagmin-1+release+in+vitro&rft.volume=273&rft.issue=35&rft.pages=22224-31&rft.date=1998-08&rft_id=info%3Ahdl%2F2158%2F26736&rft_id=info%3Apmid%2F9712836&rft_id=info%3Adoi%2F10.1074%2Fjbc.273.35.22224&rft.aulast=Mouta+Carreira&rft.aufirst=C&rft.au=LaVallee%2C+TM&rft.au=Tarantini%2C+F&rft.au=Jackson%2C+A&rft.au=Lathrop%2C+JT&rft.au=Hampton%2C+B&rft.au=Burgess%2C+WH&rft.au=Maciag%2C+T&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.273.35.22224&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+1" class="Z3988"></span></span> </li> <li id="cite_note-pmid11432880-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11432880_24-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLandriscinaBagaláMandinovaSoldi2001" class="citation journal cs1">Landriscina M, Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T (July 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M102925200">"Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress"</a>. <i>The Journal of Biological Chemistry</i>. <b>276</b> (27): 25549–57. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M102925200">10.1074/jbc.M102925200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11432880">11432880</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Copper+induces+the+assembly+of+a+multiprotein+aggregate+implicated+in+the+release+of+fibroblast+growth+factor+1+in+response+to+stress&rft.volume=276&rft.issue=27&rft.pages=25549-57&rft.date=2001-07&rft_id=info%3Adoi%2F10.1074%2Fjbc.M102925200&rft_id=info%3Apmid%2F11432880&rft.aulast=Landriscina&rft.aufirst=M&rft.au=Bagal%C3%A1%2C+C&rft.au=Mandinova%2C+A&rft.au=Soldi%2C+R&rft.au=Micucci%2C+I&rft.au=Bellum%2C+S&rft.au=Prudovsky%2C+I&rft.au=Maciag%2C+T&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M102925200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+1" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_1&action=edit&section=5" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns 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style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1jt4_EBI.jpg" class="mw-file-description" title="1jt4: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND VAL 109 REPLACED BY LEU (V109L)"><img alt="1jt4: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND VAL 109 REPLACED BY LEU (V109L)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/25/PDB_1jt4_EBI.jpg/180px-PDB_1jt4_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/25/PDB_1jt4_EBI.jpg/270px-PDB_1jt4_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/25/PDB_1jt4_EBI.jpg/360px-PDB_1jt4_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1jt4</b>: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND VAL 109 REPLACED BY LEU (V109L)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1jt5_EBI.jpg" class="mw-file-description" title="1jt5: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L)"><img alt="1jt5: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5d/PDB_1jt5_EBI.jpg/180px-PDB_1jt5_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5d/PDB_1jt5_EBI.jpg/270px-PDB_1jt5_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5d/PDB_1jt5_EBI.jpg/360px-PDB_1jt5_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1jt5</b>: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1jt7_EBI.jpg" class="mw-file-description" title="1jt7: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L)"><img alt="1jt7: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/PDB_1jt7_EBI.jpg/180px-PDB_1jt7_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/PDB_1jt7_EBI.jpg/270px-PDB_1jt7_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c7/PDB_1jt7_EBI.jpg/360px-PDB_1jt7_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1jt7</b>: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1jtc_EBI.jpg" class="mw-file-description" title="1jtc: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F)"><img alt="1jtc: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_1jtc_EBI.jpg/180px-PDB_1jtc_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_1jtc_EBI.jpg/270px-PDB_1jtc_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_1jtc_EBI.jpg/360px-PDB_1jtc_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1jtc</b>: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1jy0_EBI.jpg" class="mw-file-description" title="1jy0: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V)."><img alt="1jy0: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V)." src="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/PDB_1jy0_EBI.jpg/180px-PDB_1jy0_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/PDB_1jy0_EBI.jpg/270px-PDB_1jy0_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/24/PDB_1jy0_EBI.jpg/360px-PDB_1jy0_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1jy0</b>: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V).</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1k5u_EBI.jpg" class="mw-file-description" title="1k5u: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with His93 replaced by Gly (H93G)."><img alt="1k5u: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with His93 replaced by Gly (H93G)." src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f1/PDB_1k5u_EBI.jpg/180px-PDB_1k5u_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f1/PDB_1k5u_EBI.jpg/270px-PDB_1k5u_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f1/PDB_1k5u_EBI.jpg/360px-PDB_1k5u_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1k5u</b>: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with His93 replaced by Gly (H93G).</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1k5v_EBI.jpg" class="mw-file-description" title="1k5v: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with Asn106 replaced by Gly (N106G)."><img alt="1k5v: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with Asn106 replaced by Gly (N106G)." src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9f/PDB_1k5v_EBI.jpg/180px-PDB_1k5v_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9f/PDB_1k5v_EBI.jpg/270px-PDB_1k5v_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9f/PDB_1k5v_EBI.jpg/360px-PDB_1k5v_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1k5v</b>: Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with Asn106 replaced by Gly (N106G).</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1m16_EBI.jpg" class="mw-file-description" title="1m16: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V)."><img alt="1m16: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V)." src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/PDB_1m16_EBI.jpg/180px-PDB_1m16_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/PDB_1m16_EBI.jpg/270px-PDB_1m16_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/PDB_1m16_EBI.jpg/360px-PDB_1m16_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1m16</b>: Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V).</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1nzk_EBI.jpg" class="mw-file-description" title="1nzk: Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor"><img alt="1nzk: Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PDB_1nzk_EBI.jpg/180px-PDB_1nzk_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PDB_1nzk_EBI.jpg/270px-PDB_1nzk_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PDB_1nzk_EBI.jpg/360px-PDB_1nzk_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1nzk</b>: Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1p63_EBI.jpg" class="mw-file-description" title="1p63: Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form with Amino Terminal His Tag and Leu111 Replaced with Ile (L111I)"><img alt="1p63: Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form with Amino Terminal His Tag and Leu111 Replaced with Ile (L111I)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/PDB_1p63_EBI.jpg/180px-PDB_1p63_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/PDB_1p63_EBI.jpg/270px-PDB_1p63_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c3/PDB_1p63_EBI.jpg/360px-PDB_1p63_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1p63</b>: Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form with Amino Terminal His Tag and Leu111 Replaced with Ile (L111I)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1pzz_EBI.jpg" class="mw-file-description" title="1pzz: Crystal structure of FGF-1, V51N mutant"><img alt="1pzz: Crystal structure of FGF-1, V51N mutant" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1pzz_EBI.jpg/180px-PDB_1pzz_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1pzz_EBI.jpg/270px-PDB_1pzz_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1pzz_EBI.jpg/360px-PDB_1pzz_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1pzz</b>: Crystal structure of FGF-1, V51N mutant</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1q03_EBI.jpg" class="mw-file-description" title="1q03: Crystal structure of FGF-1, S50G/V51G mutant"><img alt="1q03: Crystal structure of FGF-1, S50G/V51G mutant" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/37/PDB_1q03_EBI.jpg/180px-PDB_1q03_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/37/PDB_1q03_EBI.jpg/270px-PDB_1q03_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/37/PDB_1q03_EBI.jpg/360px-PDB_1q03_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1q03</b>: Crystal structure of FGF-1, S50G/V51G mutant</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1q04_EBI.jpg" class="mw-file-description" title="1q04: Crystal structure of FGF-1, S50E/V51N"><img alt="1q04: Crystal structure of FGF-1, S50E/V51N" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d4/PDB_1q04_EBI.jpg/180px-PDB_1q04_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d4/PDB_1q04_EBI.jpg/270px-PDB_1q04_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d4/PDB_1q04_EBI.jpg/360px-PDB_1q04_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1q04</b>: Crystal structure of FGF-1, S50E/V51N</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1rg8_EBI.jpg" class="mw-file-description" title="1rg8: Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino acid form)"><img alt="1rg8: Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino acid form)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d1/PDB_1rg8_EBI.jpg/180px-PDB_1rg8_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d1/PDB_1rg8_EBI.jpg/270px-PDB_1rg8_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d1/PDB_1rg8_EBI.jpg/360px-PDB_1rg8_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1rg8</b>: Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino acid form)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1rml_EBI.jpg" class="mw-file-description" title="1rml: NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES"><img alt="1rml: NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/60/PDB_1rml_EBI.jpg/180px-PDB_1rml_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/60/PDB_1rml_EBI.jpg/270px-PDB_1rml_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/60/PDB_1rml_EBI.jpg/360px-PDB_1rml_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1rml</b>: NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1ry7_EBI.jpg" class="mw-file-description" title="1ry7: Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1"><img alt="1ry7: Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b9/PDB_1ry7_EBI.jpg/180px-PDB_1ry7_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b9/PDB_1ry7_EBI.jpg/270px-PDB_1ry7_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b9/PDB_1ry7_EBI.jpg/360px-PDB_1ry7_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ry7</b>: Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1yto_EBI.png" class="mw-file-description" title="1yto: Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor"><img alt="1yto: Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/14/PDB_1yto_EBI.png/180px-PDB_1yto_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/14/PDB_1yto_EBI.png/270px-PDB_1yto_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/14/PDB_1yto_EBI.png/360px-PDB_1yto_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1yto</b>: Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1z2v_EBI.png" class="mw-file-description" title="1z2v: Crystal Structure of Glu60 deletion Mutant of Human Acidic Fibroblast Growth Factor"><img alt="1z2v: Crystal Structure of Glu60 deletion Mutant of Human Acidic Fibroblast Growth Factor" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6a/PDB_1z2v_EBI.png/180px-PDB_1z2v_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6a/PDB_1z2v_EBI.png/270px-PDB_1z2v_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6a/PDB_1z2v_EBI.png/360px-PDB_1z2v_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1z2v</b>: Crystal Structure of Glu60 deletion Mutant of Human Acidic Fibroblast Growth Factor</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1z4s_EBI.png" class="mw-file-description" title="1z4s: Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor"><img alt="1z4s: Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/16/PDB_1z4s_EBI.png/180px-PDB_1z4s_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/16/PDB_1z4s_EBI.png/270px-PDB_1z4s_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/16/PDB_1z4s_EBI.png/360px-PDB_1z4s_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1z4s</b>: Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2afg_EBI.jpg" class="mw-file-description" title="2afg: 2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR"><img alt="2afg: 2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/PDB_2afg_EBI.jpg/180px-PDB_2afg_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/PDB_2afg_EBI.jpg/270px-PDB_2afg_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e5/PDB_2afg_EBI.jpg/360px-PDB_2afg_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2afg</b>: 2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2aqz_EBI.png" class="mw-file-description" title="2aqz: Crystal structure of FGF-1, S17T/N18T/G19 deletion mutant"><img alt="2aqz: Crystal structure of FGF-1, S17T/N18T/G19 deletion mutant" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/PDB_2aqz_EBI.png/180px-PDB_2aqz_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/PDB_2aqz_EBI.png/270px-PDB_2aqz_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/PDB_2aqz_EBI.png/360px-PDB_2aqz_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2aqz</b>: Crystal structure of FGF-1, S17T/N18T/G19 deletion mutant</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2axm_EBI.jpg" class="mw-file-description" title="2axm: HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR"><img alt="2axm: HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/16/PDB_2axm_EBI.jpg/180px-PDB_2axm_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/16/PDB_2axm_EBI.jpg/270px-PDB_2axm_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/16/PDB_2axm_EBI.jpg/360px-PDB_2axm_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2axm</b>: HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2erm_EBI.jpg" class="mw-file-description" title="2erm: Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue"><img alt="2erm: Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/PDB_2erm_EBI.jpg/180px-PDB_2erm_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/PDB_2erm_EBI.jpg/270px-PDB_2erm_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f9/PDB_2erm_EBI.jpg/360px-PDB_2erm_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2erm</b>: Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2j3p_EBI.png" class="mw-file-description" title="2j3p: CRYSTAL STRUCTURE OF RAT FGF1 AT 1.4 A"><img alt="2j3p: CRYSTAL STRUCTURE OF RAT FGF1 AT 1.4 A" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/PDB_2j3p_EBI.png/180px-PDB_2j3p_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/PDB_2j3p_EBI.png/270px-PDB_2j3p_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/43/PDB_2j3p_EBI.png/360px-PDB_2j3p_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2j3p</b>: CRYSTAL STRUCTURE OF RAT FGF1 AT 1.4 A</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Growth_factors" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Growth_factors" title="Template:Growth factors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Growth_factors" title="Template talk:Growth factors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Growth_factors" title="Special:EditPage/Template:Growth factors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Growth_factors" style="font-size:114%;margin:0 4em"><a href="/wiki/Growth_factor" title="Growth factor">Growth factors</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">Fibroblast</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF receptor</a> ligands:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FGF1" class="mw-redirect" title="FGF1">FGF1</a>/<a href="/wiki/Basic_fibroblast_growth_factor" class="mw-redirect" title="Basic fibroblast growth factor">FGF2</a>/<a href="/wiki/FGF5" title="FGF5">FGF5</a></li> <li><a href="/wiki/FGF3" title="FGF3">FGF3</a>/<a href="/wiki/FGF4" title="FGF4">FGF4</a>/<a href="/wiki/FGF6" title="FGF6">FGF6</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Keratinocyte_growth_factor" title="Keratinocyte growth factor">KGF</a></i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FGF7" title="FGF7">FGF7</a>/<a href="/wiki/FGF10" title="FGF10">FGF10</a>/<a href="/wiki/FGF22" title="FGF22">FGF22</a></li> <li><a href="/wiki/FGF8" class="mw-redirect" title="FGF8">FGF8</a>/<a href="/wiki/FGF17" title="FGF17">FGF17</a>/<a href="/wiki/FGF18" title="FGF18">FGF18</a></li> <li><a href="/wiki/FGF9" title="FGF9">FGF9</a>/<a href="/wiki/FGF16" title="FGF16">FGF16</a>/<a href="/wiki/FGF20" title="FGF20">FGF20</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>FGF homologous factors:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FGF11" title="FGF11">FGF11</a>(FHF3)</li> <li><a href="/wiki/FGF12" title="FGF12">FGF12</a>(FHF1)</li> <li><a href="/wiki/FGF13" title="FGF13">FGF13</a>(FHF2)</li> <li><a href="/wiki/FGF14" title="FGF14">FGF14</a>(FHF4)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>hormone-like:</i> <a href="/wiki/FGF15/19" title="FGF15/19">FGF15/19</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FGF15" title="FGF15">FGF15</a></li> <li><a href="/wiki/FGF19" title="FGF19">FGF19</a></li> <li><a href="/wiki/FGF21" class="mw-redirect" title="FGF21">FGF21</a></li> <li><a href="/wiki/Fibroblast_growth_factor_23" title="Fibroblast growth factor 23">FGF23</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/EGF-like_domain" title="EGF-like domain">EGF-like domain</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TGF_alpha" title="TGF alpha">TGFα</a></li> <li><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">HB-EGF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TGF_beta_signaling_pathway" title="TGF beta signaling pathway">TGFβ pathway</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> <ul><li><a href="/wiki/TGF_beta_1" title="TGF beta 1">TGFβ1</a></li> <li><a href="/wiki/TGF_beta_2" title="TGF beta 2">TGFβ2</a></li> <li><a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">TGFβ3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Insulin/IGF/Relaxin_family" title="Insulin/IGF/Relaxin family">Insulin/IGF/<br />Relaxin family</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Insulin" title="Insulin">Insulin</a> and <a href="/wiki/Insulin-like_growth_factor" title="Insulin-like growth factor">Insulin-like growth factor</a></i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Insulin-like_growth_factor_1" title="Insulin-like growth factor 1">IGF1</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">IGF2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Relaxin_family_peptide_hormones" title="Relaxin family peptide hormones">Relaxin family peptide hormones</a></i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/INSL3" title="INSL3">INSL3</a></li> <li><a href="/wiki/INSL4" title="INSL4">INSL4</a></li> <li><a href="/wiki/INSL5" title="INSL5">INSL5</a></li> <li><a href="/wiki/INSL6" class="mw-redirect" title="INSL6">INSL6</a></li> <li><a href="/wiki/Relaxin" title="Relaxin">Relaxin</a> <ul><li><a href="/w/index.php?title=RLN1&action=edit&redlink=1" class="new" title="RLN1 (page does not exist)">1</a></li> <li><a href="/w/index.php?title=RLN2&action=edit&redlink=1" class="new" title="RLN2 (page does not exist)">2</a></li> <li><a href="/wiki/Relaxin-3" title="Relaxin-3">3</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">Platelet-derived</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PDGFA" title="PDGFA">PDGFA</a></li> <li><a href="/wiki/PDGFB" title="PDGFB">PDGFB</a></li> <li><a href="/wiki/PDGFC" title="PDGFC">PDGFC</a></li> <li><a href="/wiki/PDGFD" title="PDGFD">PDGFD</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vascular_endothelial_growth_factor" title="Vascular endothelial growth factor">Vascular endothelial</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vascular_endothelial_growth_factor_A" title="Vascular endothelial growth factor A">VEGF-A</a></li> <li><a href="/wiki/Vascular_endothelial_growth_factor_B" title="Vascular endothelial growth factor B">VEGF-B</a></li> <li><a href="/wiki/Vascular_endothelial_growth_factor_C" title="Vascular endothelial growth factor C">VEGF-C</a></li> <li><a href="/wiki/C-fos_induced_growth_factor" class="mw-redirect" title="C-fos induced growth factor">VEGF-D</a></li> <li><a href="/wiki/Placental_growth_factor" title="Placental growth factor">PGF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">Nerve</a></li> <li><a href="/wiki/Hepatocyte_growth_factor" title="Hepatocyte growth factor">Hepatocyte</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Intercellular_signaling_peptides_and_proteins_/_ligands" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Intercellular_signaling_peptides_and_proteins" title="Template:Intercellular signaling peptides and proteins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Intercellular_signaling_peptides_and_proteins" class="mw-redirect" title="Template talk:Intercellular signaling peptides and proteins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Intercellular_signaling_peptides_and_proteins" title="Special:EditPage/Template:Intercellular signaling peptides and proteins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Intercellular_signaling_peptides_and_proteins_/_ligands" style="font-size:114%;margin:0 4em">Intercellular signaling peptides and proteins / <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligands</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Growth_factor" title="Growth factor">Growth factors</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">Epidermal growth factor</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">Fibroblast growth factor</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">Nerve growth factor</a></li> <li><a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">Platelet-derived growth factor</a></li> <li><a href="/wiki/Transforming_growth_factor_beta_superfamily" title="Transforming growth factor beta superfamily">Transforming growth factor beta superfamily</a></li> <li><a href="/wiki/Vascular_endothelial_growth_factor" title="Vascular endothelial growth factor">Vascular endothelial growth factor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Ephrin" title="Ephrin">Ephrin</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EFNA1" class="mw-redirect" title="EFNA1">EFNA1</a></li> <li><a href="/wiki/EFNA2" class="mw-redirect" title="EFNA2">EFNA2</a></li> <li><a href="/wiki/EFNA3" class="mw-redirect" title="EFNA3">EFNA3</a></li> <li><a href="/wiki/EFNA4" class="mw-redirect" title="EFNA4">EFNA4</a></li> <li><a href="/wiki/EFNA5" class="mw-redirect" title="EFNA5">EFNA5</a></li> <li><a href="/wiki/EFNB1" class="mw-redirect" title="EFNB1">EFNB1</a></li> <li><a href="/wiki/EFNB2" class="mw-redirect" title="EFNB2">EFNB2</a></li> <li><a href="/wiki/EFNB3" class="mw-redirect" title="EFNB3">EFNB3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adipokine" title="Adipokine">Adipokine</a></li> <li><a href="/wiki/Agouti_signaling_protein" class="mw-redirect" title="Agouti signaling protein">Agouti signaling protein</a></li> <li><a href="/wiki/Agouti-related_protein" class="mw-redirect" title="Agouti-related protein">Agouti-related protein</a></li> <li><a href="/wiki/Angiogenic_protein" class="mw-redirect" title="Angiogenic protein">Angiogenic protein</a></li> <li><a href="/wiki/CCN_intercellular_signaling_protein" class="mw-redirect" title="CCN intercellular signaling protein">CCN intercellular signaling protein</a> <ul><li><a href="/wiki/Cysteine-rich_protein_61" class="mw-redirect" title="Cysteine-rich protein 61">Cysteine-rich protein 61</a></li> <li><a href="/wiki/Connective_tissue_growth_factor" class="mw-redirect" title="Connective tissue growth factor">Connective tissue growth factor</a></li> <li><a href="/wiki/Nephroblastoma_overexpressed_protein" class="mw-redirect" title="Nephroblastoma overexpressed protein">Nephroblastoma overexpressed protein</a></li></ul></li> <li><a href="/wiki/Cytokine" title="Cytokine">Cytokine</a></li> <li><a href="/wiki/Endothelin" title="Endothelin">Endothelin</a> <ul><li><a href="/wiki/EDN1" class="mw-redirect" title="EDN1">EDN1</a></li> <li><a href="/wiki/EDN2" class="mw-redirect" title="EDN2">EDN2</a></li> <li><a href="/wiki/EDN3" class="mw-redirect" title="EDN3">EDN3</a></li></ul></li> <li><a href="/wiki/Hedgehog_protein" class="mw-redirect" title="Hedgehog protein">Hedgehog protein</a></li> <li><a href="/wiki/Interferon" title="Interferon">Interferon</a></li> <li><a href="/wiki/Kinin" title="Kinin">Kinin</a></li> <li><a href="/wiki/Parathyroid_hormone-related_protein" title="Parathyroid hormone-related protein">Parathyroid hormone-related protein</a></li> <li><a href="/wiki/Semaphorin" title="Semaphorin">Semaphorin</a></li> <li><a href="/wiki/Somatomedin" title="Somatomedin">Somatomedin</a></li> <li><a href="/wiki/Tolloid-like_metalloproteinase" class="mw-redirect" title="Tolloid-like metalloproteinase">Tolloid-like metalloproteinase</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">Tumor necrosis factor</a></li> <li><a href="/wiki/Wnt_protein" class="mw-redirect" title="Wnt protein">Wnt protein</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i>see also <a href="/wiki/Template:Extracellular_ligand_disorders" title="Template:Extracellular ligand disorders">extracellular ligand disorders</a></i></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Growth_factor_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Growth_factor_receptor_modulators" title="Template talk:Growth factor receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Growth_factor_receptor_modulators" title="Special:EditPage/Template:Growth factor receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Growth_factor_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">Growth factor receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Angiopoietin_receptor" title="Angiopoietin receptor">Angiopoietin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Angiopoietin_1" title="Angiopoietin 1">Angiopoietin 1</a></li> <li><a href="/wiki/Angiopoietin_4" class="mw-redirect" title="Angiopoietin 4">Angiopoietin 4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Angiopoietin_2" class="mw-redirect" title="Angiopoietin 2">Angiopoietin 2</a></li> <li><a href="/w/index.php?title=Angiopoietin_3&action=edit&redlink=1" class="new" title="Angiopoietin 3 (page does not exist)">Angiopoietin 3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Evinacumab" title="Evinacumab">Evinacumab</a> (against angiopoietin 3)</li> <li><a href="/wiki/Nesvacumab" title="Nesvacumab">Nesvacumab</a> (against angiopoietin 2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Axokine" class="mw-redirect" title="Axokine">Axokine</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></li> <li><a href="/w/index.php?title=Dapiclermin&action=edit&redlink=1" class="new" title="Dapiclermin (page does not exist)">Dapiclermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF (ErbB)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF<br /><small>(ErbB1/HER1)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Amphiregulin" title="Amphiregulin">Amphiregulin</a></li> <li><a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF (urogastrone)</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Epiregulin" title="Epiregulin">Epiregulin</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Murodermin" title="Murodermin">Murodermin</a></li> <li><a href="/wiki/Nepidermin" title="Nepidermin">Nepidermin</a></li> <li><a href="/wiki/Transforming_growth_factor_alpha" class="mw-redirect" title="Transforming growth factor alpha">Transforming growth factor alpha (TGFα)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Brigatinib" title="Brigatinib">Brigatinib</a></li> <li><a href="/wiki/Canertinib" title="Canertinib">Canertinib</a></li> <li><a href="/wiki/Dacomitinib" title="Dacomitinib">Dacomitinib</a></li> <li><a href="/wiki/Erlotinib" title="Erlotinib">Erlotinib</a></li> <li><a href="/wiki/Gefitinib" title="Gefitinib">Gefitinib</a></li> <li><a href="/wiki/Grandinin" title="Grandinin">Grandinin</a></li> <li><a href="/wiki/Icotinib" title="Icotinib">Icotinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Osimertinib" title="Osimertinib">Osimertinib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Cetuximab" title="Cetuximab">Cetuximab</a></li> <li><a href="/w/index.php?title=Depatuxizumab&action=edit&redlink=1" class="new" title="Depatuxizumab (page does not exist)">Depatuxizumab</a></li> <li><a href="/wiki/Depatuxizumab_mafodotin" title="Depatuxizumab mafodotin">Depatuxizumab mafodotin</a></li> <li><a href="/wiki/Futuximab" title="Futuximab">Futuximab</a></li> <li><a href="/wiki/Imgatuzumab" title="Imgatuzumab">Imgatuzumab</a></li> <li><a href="/wiki/Matuzumab" title="Matuzumab">Matuzumab</a></li> <li><a href="/wiki/Necitumumab" title="Necitumumab">Necitumumab</a></li> <li><a href="/wiki/Nimotuzumab" title="Nimotuzumab">Nimotuzumab</a></li> <li><a href="/wiki/Panitumumab" title="Panitumumab">Panitumumab</a></li> <li><a href="/wiki/Zalutumumab" title="Zalutumumab">Zalutumumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">ErbB2/HER2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <i>Unknown/none</i></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ertumaxomab" title="Ertumaxomab">Ertumaxomab</a></li> <li><a href="/wiki/Pertuzumab" title="Pertuzumab">Pertuzumab</a></li> <li><a href="/wiki/Trastuzumab" title="Trastuzumab">Trastuzumab</a></li> <li><a href="/wiki/Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">Trastuzumab deruxtecan</a></li> <li><a href="/w/index.php?title=Trastuzumab_duocarmazine&action=edit&redlink=1" class="new" title="Trastuzumab duocarmazine (page does not exist)">Trastuzumab duocarmazine</a></li> <li><a href="/wiki/Trastuzumab_emtansine" title="Trastuzumab emtansine">Trastuzumab emtansine</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Mubritinib" title="Mubritinib">Mubritinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Tucatinib" title="Tucatinib">Tucatinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER3" class="mw-redirect" title="HER3">ErbB3/HER3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/CSPG5" title="CSPG5">6 (neuroglycan C)</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Duligotumab" class="mw-redirect" title="Duligotumab">Duligotumab</a></li> <li><a href="/wiki/Patritumab" title="Patritumab">Patritumab</a></li> <li><a href="/wiki/Seribantumab" title="Seribantumab">Seribantumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER4" class="mw-redirect" title="HER4">ErbB4/HER4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/NRG3" class="mw-redirect" title="NRG3">3</a>, <a href="/wiki/NRG4" class="mw-redirect" title="NRG4">4</a>, <a href="/w/index.php?title=Tomoregulin&action=edit&redlink=1" class="new" title="Tomoregulin (page does not exist)">5 (tomoregulin, TMEFF)</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF20" title="FGF20">20</a>)</li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li> <li><a href="/w/index.php?title=Velafermin&action=edit&redlink=1" class="new" title="Velafermin (page does not exist)">Velafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">FGFR2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF7" title="FGF7">7</a> (<a href="/wiki/Keratinocyte_growth_factor" title="Keratinocyte growth factor">KGF</a>), <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF17" title="FGF17">17</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF22" title="FGF22">22</a>)</li> <li><a href="/wiki/Palifermin" title="Palifermin">Palifermin</a></li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Aprutumab&action=edit&redlink=1" class="new" title="Aprutumab (page does not exist)">Aprutumab</a></li> <li><a href="/w/index.php?title=Aprutumab_ixadotin&action=edit&redlink=1" class="new" title="Aprutumab ixadotin (page does not exist)">Aprutumab ixadotin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Infigratinib" title="Infigratinib">Infigratinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF23" class="mw-redirect" title="FGF23">23</a>)</li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Burosumab" title="Burosumab">Burosumab</a> (against FGF23)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF19" title="FGF19">19</a>)</li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/FGF15/19" title="FGF15/19">FGF15/19</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Hepatocyte_growth_factor_receptor" title="Hepatocyte growth factor receptor">HGF (c-Met)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Fosgonimeton" title="Fosgonimeton">Fosgonimeton</a></li> <li><a href="/wiki/Hepatocyte_growth_factor" title="Hepatocyte growth factor">Hepatocyte growth factor</a></li></ul> <ul><li><i>Potentiators:</i> <a href="/wiki/Dihexa" title="Dihexa">Dihexa (PNB-0408)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AM7_(drug)&action=edit&redlink=1" class="new" title="AM7 (drug) (page does not exist)">AM7</a></li> <li><a href="/w/index.php?title=AMG-458&action=edit&redlink=1" class="new" title="AMG-458 (page does not exist)">AMG-458</a></li> <li><a href="/w/index.php?title=Amuvatinib&action=edit&redlink=1" class="new" title="Amuvatinib (page does not exist)">Amuvatinib</a></li> <li><a href="/w/index.php?title=BMS-777607&action=edit&redlink=1" class="new" title="BMS-777607 (page does not exist)">BMS-777607</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Capmatinib" title="Capmatinib">Capmatinib</a></li> <li><a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a></li> <li><a href="/wiki/Foretinib" title="Foretinib">Foretinib</a></li> <li><a href="/w/index.php?title=Golvatinib&action=edit&redlink=1" class="new" title="Golvatinib (page does not exist)">Golvatinib</a></li> <li><a href="/w/index.php?title=INCB28060&action=edit&redlink=1" class="new" title="INCB28060 (page does not exist)">INCB28060</a></li> <li><a href="/w/index.php?title=JNJ-38877605&action=edit&redlink=1" class="new" title="JNJ-38877605 (page does not exist)">JNJ-38877605</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/w/index.php?title=MK-2461&action=edit&redlink=1" class="new" title="MK-2461 (page does not exist)">MK-2461</a></li> <li><a href="/w/index.php?title=PF-04217903&action=edit&redlink=1" class="new" title="PF-04217903 (page does not exist)">PF-04217903</a></li> <li><a href="/w/index.php?title=PF-2341066&action=edit&redlink=1" class="new" title="PF-2341066 (page does not exist)">PF-2341066</a></li> <li><a href="/w/index.php?title=PHA-665752&action=edit&redlink=1" class="new" title="PHA-665752 (page does not exist)">PHA-665752</a></li> <li><a href="/w/index.php?title=SU-11274&action=edit&redlink=1" class="new" title="SU-11274 (page does not exist)">SU-11274</a></li> <li><a href="/wiki/Tivantinib" title="Tivantinib">Tivantinib</a></li> <li><a href="/wiki/Volitinib" class="mw-redirect" title="Volitinib">Volitinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Emibetuzumab" title="Emibetuzumab">Emibetuzumab</a></li> <li><a href="/wiki/Ficlatuzumab" title="Ficlatuzumab">Ficlatuzumab</a></li> <li><a href="/wiki/Flanvotumab" title="Flanvotumab">Flanvotumab</a></li> <li><a href="/wiki/Onartuzumab" title="Onartuzumab">Onartuzumab</a></li> <li><a href="/wiki/Rilotumumab" title="Rilotumumab">Rilotumumab</a></li> <li><a href="/w/index.php?title=Telisotuzumab&action=edit&redlink=1" class="new" title="Telisotuzumab (page does not exist)">Telisotuzumab</a></li> <li><a href="/wiki/Telisotuzumab_vedotin" title="Telisotuzumab vedotin">Telisotuzumab vedotin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Somatomedin_receptor" title="Somatomedin receptor">IGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">IGF-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Des(1-3)IGF-1" title="Des(1-3)IGF-1">des(1-3)IGF-1</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1" title="Insulin-like growth factor 1">Insulin-like growth factor-1 (somatomedin C)</a></li> <li><a href="/wiki/IGF-1_LR3" title="IGF-1 LR3">IGF-1 LR3</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li> <li><a href="/wiki/Insulin" title="Insulin">Insulin</a></li> <li><a href="/wiki/Mecasermin" title="Mecasermin">Mecasermin</a></li> <li><a href="/wiki/Mecasermin_rinfabate" title="Mecasermin rinfabate">Mecasermin rinfabate</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=BMS-754807&action=edit&redlink=1" class="new" title="BMS-754807 (page does not exist)">BMS-754807</a></li> <li><a href="/wiki/Linsitinib" title="Linsitinib">Linsitinib</a></li> <li><a href="/w/index.php?title=NVP-ADW742&action=edit&redlink=1" class="new" title="NVP-ADW742 (page does not exist)">NVP-ADW742</a></li> <li><a href="/w/index.php?title=NVP-AEW541&action=edit&redlink=1" class="new" title="NVP-AEW541 (page does not exist)">NVP-AEW541</a></li> <li><a href="/w/index.php?title=OSl-906&action=edit&redlink=1" class="new" title="OSl-906 (page does not exist)">OSl-906</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=AVE-1642&action=edit&redlink=1" class="new" title="AVE-1642 (page does not exist)">AVE-1642</a></li> <li><a href="/wiki/Cixutumumab" title="Cixutumumab">Cixutumumab</a></li> <li><a href="/wiki/Dalotuzumab" title="Dalotuzumab">Dalotuzumab</a></li> <li><a href="/wiki/Figitumumab" title="Figitumumab">Figitumumab</a></li> <li><a href="/wiki/Ganitumab" title="Ganitumab">Ganitumab</a></li> <li><a href="/wiki/Robatumumab" title="Robatumumab">Robatumumab</a></li> <li><a href="/w/index.php?title=R1507&action=edit&redlink=1" class="new" title="R1507 (page does not exist)">R1507</a></li> <li><a href="/wiki/Teprotumumab" title="Teprotumumab">Teprotumumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">IGF-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dusigitumab" title="Dusigitumab">Dusigitumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Binding proteins:</i> <a href="/wiki/Insulin-like_growth_factor-binding_protein" title="Insulin-like growth factor-binding protein">IGFBP</a> (<a href="/wiki/IGFBP1" title="IGFBP1">1</a>, <a href="/wiki/IGFBP2" title="IGFBP2">2</a>, <a href="/wiki/IGFBP3" title="IGFBP3">3</a>, <a href="/wiki/IGFBP4" title="IGFBP4">4</a>, <a href="/wiki/IGFBP5" title="IGFBP5">5</a>, <a href="/wiki/IGFBP6" title="IGFBP6">6</a>, <a href="/wiki/IGFBP7" title="IGFBP7">7</a>)</li></ul> <ul><li><i>Cleavage products/derivatives with unknown target:</i> <a href="/w/index.php?title=Glypromate&action=edit&redlink=1" class="new" title="Glypromate (page does not exist)">Glypromate (GPE, (1-3)IGF-1)</a></li> <li><a href="/wiki/Trofinetide" title="Trofinetide">Trofinetide</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">LNGF (p75<sup>NTR</sup>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/w/index.php?title=EVT-901&action=edit&redlink=1" class="new" title="EVT-901 (page does not exist)">EVT-901 (SAR-127963)</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Antibodies:</i> <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=LEVI-04&action=edit&redlink=1" class="new" title="LEVI-04 (page does not exist)">LEVI-04 (p75<sup>NTR</sup>-Fc)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Becaplermin" title="Becaplermin">Becaplermin</a></li> <li><a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">Platelet-derived growth factor</a> (<a href="/wiki/PDGFA" title="PDGFA">A</a>, <a href="/wiki/PDGFB" title="PDGFB">B</a>, <a href="/wiki/PDGFC" title="PDGFC">C</a>, <a href="/wiki/PDGFD" title="PDGFD">D</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Avapritinib" title="Avapritinib">Avapritinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Crenolanib" title="Crenolanib">Crenolanib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Radotinib" title="Radotinib">Radotinib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Olaratumab" title="Olaratumab">Olaratumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Tovetumab" title="Tovetumab">Tovetumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET (GFL)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B11" class="mw-redirect" title="GFRα1">GFRα1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Glial_cell_line-derived_neurotrophic_factor" title="Glial cell line-derived neurotrophic factor">Glial cell line-derived neurotrophic factor (GDNF)</a></li> <li><a href="/w/index.php?title=Liatermin&action=edit&redlink=1" class="new" title="Liatermin (page does not exist)">Liatermin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B12" class="mw-redirect" title="GFRα2">GFRα2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neurturin" title="Neurturin">Neurturin (NRTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B13" class="mw-redirect" title="GFRα3">GFRα3</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Artemin" title="Artemin">Artemin (ARTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B14" class="mw-redirect" title="GFRα4">GFRα4</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Persephin" title="Persephin">Persephin (PSPN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CD117" class="mw-redirect" title="CD117">SCF (c-Kit)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Ancestim" title="Ancestim">Ancestim</a></li> <li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">Stem cell factor</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Dasatinib" title="Dasatinib">Dasatinib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Nilotinib" title="Nilotinib">Nilotinib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Transforming_growth_factor_beta_receptor" class="mw-redirect" title="Transforming growth factor beta receptor">TGFβ</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Trk_receptor" title="Trk receptor">Trk</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">TrkA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/w/index.php?title=Gambogic_amide&action=edit&redlink=1" class="new" title="Gambogic amide (page does not exist)">Gambogic amide</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Tavilermide" title="Tavilermide">Tavilermide</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/wiki/FX007" class="mw-redirect" title="FX007">FX007</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Negative allosteric modulators:</i> <a href="/w/index.php?title=VM-902A&action=edit&redlink=1" class="new" title="VM-902A (page does not exist)">VM-902A</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=Milciclib&action=edit&redlink=1" class="new" title="Milciclib (page does not exist)">Milciclib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/w/index.php?title=SNA-120&action=edit&redlink=1" class="new" title="SNA-120 (page does not exist)">SNA-120 (pegylated K252a)</a>)</li></ul> <ul><li><i>Antibodies:</i> <i>Against TrkA:</i> <a href="/w/index.php?title=GBR-900&action=edit&redlink=1" class="new" title="GBR-900 (page does not exist)">GBR-900</a>; <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=ReN-1820&action=edit&redlink=1" class="new" title="ReN-1820 (page does not exist)">ReN-1820 (TrkAd5)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkB_receptor" class="mw-redirect" title="TrkB receptor">TrkB</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=3,7-Dihydroxyflavone&action=edit&redlink=1" class="new" title="3,7-Dihydroxyflavone (page does not exist)">3,7-DHF</a></li> <li><a href="/w/index.php?title=3,7,8,2%27-Tetrahydroxyflavone&action=edit&redlink=1" class="new" title="3,7,8,2'-Tetrahydroxyflavone (page does not exist)">3,7,8,2'-THF</a></li> <li><a href="/wiki/4%27-Dimethylamino-7,8-dihydroxyflavone" class="mw-redirect" title="4'-Dimethylamino-7,8-dihydroxyflavone">4'-DMA-7,8-DHF</a></li> <li><a href="/w/index.php?title=7,3%E2%80%B2-Dihydroxyflavone&action=edit&redlink=1" class="new" title="7,3′-Dihydroxyflavone (page does not exist)">7,3'-DHF</a></li> <li><a href="/wiki/7,8-Dihydroxyflavone" class="mw-redirect" title="7,8-Dihydroxyflavone">7,8-DHF</a></li> <li><a href="/w/index.php?title=7,8,2%27-Trihydroxyflavone&action=edit&redlink=1" class="new" title="7,8,2'-Trihydroxyflavone (page does not exist)">7,8,2'-THF</a></li> <li><a href="/wiki/7,8,3%27-Trihydroxyflavone" title="7,8,3'-Trihydroxyflavone">7,8,3'-THF</a></li> <li><a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Deoxygedunin" title="Deoxygedunin">Deoxygedunin</a></li> <li><a href="/wiki/Deprenyl" title="Deprenyl">Deprenyl</a></li> <li><a href="/wiki/Diosmetin" title="Diosmetin">Diosmetin</a></li> <li><a href="/w/index.php?title=DMAQ-B1&action=edit&redlink=1" class="new" title="DMAQ-B1 (page does not exist)">DMAQ-B1</a></li> <li><a href="/wiki/HIOC" title="HIOC">HIOC</a></li> <li><a href="/wiki/LM22A-4" title="LM22A-4">LM22A-4</a></li> <li><a href="/wiki/N-Acetylserotonin" title="N-Acetylserotonin">N-Acetylserotonin</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li> <li><a href="/wiki/Norwogonin" title="Norwogonin">Norwogonin (5,7,8-THF)</a></li> <li><a href="/wiki/R7_(drug)" title="R7 (drug)">R7</a></li> <li><a href="/wiki/R13_(drug)" title="R13 (drug)">R13</a></li> <li><a href="/w/index.php?title=TDP6&action=edit&redlink=1" class="new" title="TDP6 (page does not exist)">TDP6</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/ANA-12" title="ANA-12">ANA-12</a></li> <li><a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li> <li><a href="/wiki/Gossypetin" title="Gossypetin">Gossypetin (3,5,7,8,3',4'-HHF)</a></li></ul> <ul><li><i>Ligands:</i> <a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkC_receptor" class="mw-redirect" title="TrkC receptor">TrkC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Vascular_endothelial_growth_factor_receptor" class="mw-redirect" title="Vascular endothelial growth factor receptor">VEGF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Placental_growth_factor" title="Placental growth factor">Placental growth factor (PGF)</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/w/index.php?title=Telbermin&action=edit&redlink=1" class="new" title="Telbermin (page does not exist)">Telbermin</a></li> <li><a href="/wiki/Vascular_endothelial_growth_factor" title="Vascular endothelial growth factor">VEGF</a> (<a href="/wiki/Vascular_endothelial_growth_factor_A" title="Vascular endothelial growth factor A">A</a>, <a href="/wiki/Vascular_endothelial_growth_factor_B" title="Vascular endothelial growth factor B">B</a>, <a href="/wiki/Vascular_endothelial_growth_factor_C" title="Vascular endothelial growth factor C">C</a>, <a href="/wiki/Vascular_endothelial_growth_factor_D" class="mw-redirect" title="Vascular endothelial growth factor D">D (FIGF)</a>)</li></ul> <ul><li><i>Allosteric modulators:</i> <a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Cediranib" title="Cediranib">Cediranib</a></li> <li><a href="/wiki/Fruquintinib" title="Fruquintinib">Fruquintinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Pegaptanib" title="Pegaptanib">Pegaptanib</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/wiki/Regorafenib" title="Regorafenib">Regorafenib</a></li> <li><a href="/wiki/Semaxanib" title="Semaxanib">Semaxanib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li> <li><a href="/wiki/Tivozanib" title="Tivozanib">Tivozanib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Alacizumab_pegol" title="Alacizumab pegol">Alacizumab pegol</a></li> <li><a href="/wiki/Bevacizumab" title="Bevacizumab">Bevacizumab</a></li> <li><a href="/wiki/Icrucumab" title="Icrucumab">Icrucumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Ranibizumab" title="Ranibizumab">Ranibizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Additional growth factors:</i> <a href="/wiki/Adrenomedullin" title="Adrenomedullin">Adrenomedullin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Connective_tissue_growth_factor" class="mw-redirect" title="Connective tissue growth factor">Connective tissue growth factor (CTGF)</a></li> <li><a href="/wiki/Ephrin" title="Ephrin">Ephrins</a> (<a href="/wiki/EFNA1" class="mw-redirect" title="EFNA1">A1</a>, <a href="/wiki/EFNA2" class="mw-redirect" title="EFNA2">A2</a>, <a href="/wiki/EFNA3" class="mw-redirect" title="EFNA3">A3</a>, <a href="/wiki/EFNA4" class="mw-redirect" title="EFNA4">A4</a>, <a href="/wiki/EFNA5" class="mw-redirect" title="EFNA5">A5</a>, <a href="/wiki/EFNB1" class="mw-redirect" title="EFNB1">B1</a>, <a href="/wiki/EFNB2" class="mw-redirect" title="EFNB2">B2</a>, <a href="/wiki/EFNB3" class="mw-redirect" title="EFNB3">B3</a>)</li> <li><a href="/wiki/Erythropoietin" title="Erythropoietin">Erythropoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Glucose-6-phosphate_isomerase" title="Glucose-6-phosphate isomerase">Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)</a></li> <li><a href="/wiki/Glia_maturation_factor" title="Glia maturation factor">Glia maturation factor (GMF)</a></li> <li><a href="/wiki/Hepatoma-derived_growth_factor" title="Hepatoma-derived growth factor">Hepatoma-derived growth factor (HDGF)</a></li> <li><a href="/wiki/Interleukin" title="Interleukin">Interleukins</a>/<a href="/wiki/T-cell_growth_factor" title="T-cell growth factor">T-cell growth factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">Leukemia inhibitory factor (LIF)</a></li> <li><a href="/wiki/Macrophage-stimulating_protein" class="mw-redirect" title="Macrophage-stimulating protein">Macrophage-stimulating protein (MSP; HLP, HGFLP)</a></li> <li><a href="/wiki/Midkine" title="Midkine">Midkine (NEGF2)</a></li> <li><a href="/wiki/Migration-stimulating_factor" class="mw-redirect" title="Migration-stimulating factor">Migration-stimulating factor (MSF; PRG4)</a></li> <li><a href="/wiki/Oncomodulin" title="Oncomodulin">Oncomodulin</a></li> <li><a href="/wiki/Pituitary_adenylate_cyclase-activating_peptide" title="Pituitary adenylate cyclase-activating peptide">Pituitary adenylate cyclase-activating peptide (PACAP)</a></li> <li><a href="/wiki/Pleiotrophin" title="Pleiotrophin">Pleiotrophin</a></li> <li><a href="/wiki/Renalase" title="Renalase">Renalase</a></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt signaling proteins</a></li></ul> <ul><li><i>Additional growth factor receptor modulators:</i> <a href="/wiki/Cerebrolysin" title="Cerebrolysin">Cerebrolysin</a> (neurotrophin mixture)</li></ul> </div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐web.codfw.main‐f69cdc8f6‐psqwl Cached time: 20241122141556 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 1.364 seconds Real time 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