CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available" lang="en" dir="ltr"> <head> <meta charset="UTF-8"> <title>Tucatinib - Wikipedia</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )enwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":["",""],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"dmy", "wgMonthNames":["","January","February","March","April","May","June","July","August","September","October","November","December"],"wgRequestId":"dd0c1b7a-6106-450e-a03e-8da77488609d","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"Tucatinib","wgTitle":"Tucatinib","wgCurRevisionId":1234794657,"wgRevisionId":1234794657,"wgArticleId":53047585,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["All articles with dead external links","Articles with dead external links from March 2023","Articles with permanently dead external links","Source attribution","Articles with short description","Short description matches Wikidata","Use dmy dates from January 2023","Drugs with non-standard legal status","Articles containing unverified chemical infoboxes","Articles containing potentially dated statements from April 2020","All articles containing potentially dated statements", "Antineoplastic drugs","Cancer treatments","CYP3A4 inhibitors","Orphan drugs","Quinazolines","Receptor tyrosine kinase inhibitors","Triazolopyridines"],"wgPageViewLanguage":"en","wgPageContentLanguage":"en","wgPageContentModel":"wikitext","wgRelevantPageName":"Tucatinib","wgRelevantArticleId":53047585,"wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false,"wgFlaggedRevsParams":{"tags":{"status":{"levels":1}}},"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"en","pageLanguageDir":"ltr","pageVariantFallbacks":"en"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":false,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":20000,"wgRelatedArticlesCompat":[],"wgCentralAuthMobileDomain":false,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition" :"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q25100690","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false,"wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false};RLSTATE={"ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"}; RLPAGEMODULES=["ext.cite.ux-enhancements","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.ReferenceTooltips","ext.gadget.switcher","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups","ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession","wikibase.sidebar.tracking"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=en&modules=ext.cite.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=en&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=en&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.4"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Tucatinib.svg/1200px-Tucatinib.svg.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="478"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Tucatinib.svg/800px-Tucatinib.svg.png"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="319"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Tucatinib.svg/640px-Tucatinib.svg.png"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="255"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="Tucatinib - Wikipedia"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//en.m.wikipedia.org/wiki/Tucatinib"> <link rel="alternate" type="application/x-wiki" title="Edit this page" href="/w/index.php?title=Tucatinib&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (en)"> <link rel="EditURI" type="application/rsd+xml" href="//en.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://en.wikipedia.org/wiki/Tucatinib"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en"> <link rel="alternate" type="application/atom+xml" title="Wikipedia Atom feed" href="/w/index.php?title=Special:RecentChanges&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="//login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-Tucatinib rootpage-Tucatinib skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Jump to content</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Main menu" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Main menu</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Main menu</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">hide</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigation </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Main_Page" title="Visit the main page [z]" accesskey="z"><span>Main page</span></a></li><li id="n-contents" class="mw-list-item"><a href="/wiki/Wikipedia:Contents" title="Guides to browsing Wikipedia"><span>Contents</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:Current_events" title="Articles related to current events"><span>Current events</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Special:Random" title="Visit a randomly selected article [x]" accesskey="x"><span>Random article</span></a></li><li id="n-aboutsite" class="mw-list-item"><a href="/wiki/Wikipedia:About" title="Learn about Wikipedia and how it works"><span>About Wikipedia</span></a></li><li id="n-contactpage" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us" title="How to contact Wikipedia"><span>Contact us</span></a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" > <div class="vector-menu-heading"> Contribute </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Help:Contents" title="Guidance on how to use and edit Wikipedia"><span>Help</span></a></li><li id="n-introduction" class="mw-list-item"><a href="/wiki/Help:Introduction" title="Learn how to edit Wikipedia"><span>Learn to edit</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Community_portal" title="The hub for editors"><span>Community portal</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Special:RecentChanges" title="A list of recent changes to Wikipedia [r]" accesskey="r"><span>Recent changes</span></a></li><li id="n-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_upload_wizard" title="Add images or other media for use on Wikipedia"><span>Upload file</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Main_Page" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="The Free Encyclopedia" src="/static/images/mobile/copyright/wikipedia-tagline-en.svg" width="117" height="13" style="width: 7.3125em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Special:Search" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Search Wikipedia [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Search</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Search Wikipedia" aria-label="Search Wikipedia" autocapitalize="sentences" title="Search Wikipedia [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Special:Search"> </div> <button class="cdx-button cdx-search-input__end-button">Search</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Personal tools"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Appearance" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Appearance</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en" class=""><span>Donate</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:CreateAccount&returnto=Tucatinib" title="You are encouraged to create an account and log in; however, it is not mandatory" class=""><span>Create account</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:UserLogin&returnto=Tucatinib" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o" class=""><span>Log in</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Log in and more options" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Personal tools" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Personal tools</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="User menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en"><span>Donate</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:CreateAccount&returnto=Tucatinib" title="You are encouraged to create an account and log in; however, it is not mandatory"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Create account</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:UserLogin&returnto=Tucatinib" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Log in</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pages for logged out editors <a href="/wiki/Help:Introduction" aria-label="Learn more about editing"><span>learn more</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:MyContributions" title="A list of edits made from this IP address [y]" accesskey="y"><span>Contributions</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:MyTalk" title="Discussion about edits from this IP address [n]" accesskey="n"><span>Talk</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Contents" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Contents</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Medical_uses" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Medical_uses"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Medical uses</span> </div> </a> <ul id="toc-Medical_uses-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Clinical_trials" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Clinical_trials"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Clinical trials</span> </div> </a> <ul id="toc-Clinical_trials-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>History</span> </div> </a> <ul id="toc-History-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Society and culture</span> </div> </a> <button aria-controls="toc-Society_and_culture-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Society and culture subsection</span> </button> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> <li id="toc-Economics" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Economics"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Economics</span> </div> </a> <ul id="toc-Economics-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Legal_status" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Legal_status"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Legal status</span> </div> </a> <ul id="toc-Legal_status-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Names" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Names"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.3</span> <span>Names</span> </div> </a> <ul id="toc-Names-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Tucatinib</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 6 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-6" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">6 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AA%D9%88%D9%83%D8%A7%D8%AA%D9%8A%D9%86%D9%8A%D8%A8" title="توكاتينيب – Arabic" lang="ar" hreflang="ar" data-title="توكاتينيب" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Tucatinib" title="Tucatinib – Spanish" lang="es" hreflang="es" data-title="Tucatinib" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%98%D7%95%D7%A7%D7%98%D7%99%D7%A0%D7%99%D7%91" title="טוקטיניב – Hebrew" lang="he" hreflang="he" data-title="טוקטיניב" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%9F%E0%AD%81%E0%AC%95%E0%AC%BE%E0%AC%9F%E0%AC%BF%E0%AC%A8%E0%AC%BF%E0%AC%AC" title="ଟୁକାଟିନିବ – Odia" lang="or" hreflang="or" data-title="ଟୁକାଟିନିବ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Tucatinib" title="Tucatinib – Portuguese" lang="pt" hreflang="pt" data-title="Tucatinib" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%9B%BE%E5%8D%A1%E6%9B%BF%E5%B0%BC" title="图卡替尼 – Chinese" lang="zh" hreflang="zh" data-title="图卡替尼" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q25100690#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Tucatinib" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Tucatinib" rel="discussion" title="Discuss improvements to the content page [t]" accesskey="t"><span>Talk</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Change language variant" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">English</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Views"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Tucatinib"><span>Read</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Tucatinib&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Tucatinib&action=history" title="Past revisions of this page [h]" accesskey="h"><span>View history</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Tools" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Tools</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Tools</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">hide</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="More options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Tucatinib"><span>Read</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Tucatinib&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Tucatinib&action=history"><span>View history</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> General </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:WhatLinksHere/Tucatinib" title="List of all English Wikipedia pages containing links to this page [j]" accesskey="j"><span>What links here</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:RecentChangesLinked/Tucatinib" rel="nofollow" title="Recent changes in pages linked from this page [k]" accesskey="k"><span>Related changes</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_Upload_Wizard" title="Upload files [u]" accesskey="u"><span>Upload file</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Special:SpecialPages" title="A list of all special pages [q]" accesskey="q"><span>Special pages</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Tucatinib&oldid=1234794657" title="Permanent link to this revision of this page"><span>Permanent link</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Tucatinib&action=info" title="More information about this page"><span>Page information</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:CiteThisPage&page=Tucatinib&id=1234794657&wpFormIdentifier=titleform" title="Information on how to cite this page"><span>Cite this page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:UrlShortener&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FTucatinib"><span>Get shortened URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FTucatinib"><span>Download QR code</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=Tucatinib&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Tucatinib&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q25100690" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Chemical compound</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Tucatinib">Tucatinib</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Tucatinib.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Tucatinib.svg/220px-Tucatinib.svg.png" decoding="async" width="220" height="88" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Tucatinib.svg/330px-Tucatinib.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Tucatinib.svg/440px-Tucatinib.svg.png 2x" data-file-width="512" data-file-height="204" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Pronunciation</th><td class="infobox-data"><span class="rt-commentedText nowrap"><span class="IPA nopopups noexcerpt" lang="en-fonipa"><a href="/wiki/Help:IPA/English" title="Help:IPA/English">/<span style="border-bottom:1px dotted"><span title="'t' in 'tie'">t</span><span title="/u/: 'u' in 'influence'">u</span><span title="/ˈ/: primary stress follows">ˈ</span><span title="'k' in 'kind'">k</span><span title="/æ/: 'a' in 'bad'">æ</span><span title="'t' in 'tie'">t</span><span title="/ɪ/: 'i' in 'kit'">ɪ</span><span title="'n' in 'nigh'">n</span><span title="/ɪ/: 'i' in 'kit'">ɪ</span><span title="'b' in 'buy'">b</span></span>/</a></span></span><br /><a href="/wiki/Help:Pronunciation_respelling_key" title="Help:Pronunciation respelling key"><i title="English pronunciation respelling">too-<span style="font-size:90%">KAT</span>-in-ib</i></a> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Tukysa</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">ONT-380, ARRY-380</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/tucatinib.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a620032.html">a620032</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Tucatinib">Tucatinib</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> D<sup id="cite_ref-TGA_Tucatinib_1-0" class="reference"><a href="#cite_note-TGA_Tucatinib-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">By mouth</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_L01" title="ATC code L01">L01EH03</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=L01EH03">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)</li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a><sup id="cite_ref-Tukysa_FDA_label_3-0" class="reference"><a href="#cite_note-Tukysa_FDA_label-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="European Union">EU</abbr>:</small> Rx-only<sup id="cite_ref-Tukysa_EPAR_4-0" class="reference"><a href="#cite_note-Tukysa_EPAR-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=937263-43-9">937263-43-9</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/51039094">51039094</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB11652">DB11652</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.34995558.html">34995558</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/234248D0HH">234248D0HH</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D11141">D11141</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL3989868">ChEMBL3989868</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID601027958">DTXSID601027958</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q25100690#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>26</sub><span title="Hydrogen">H</span><sub>24</sub><span title="Nitrogen">N</span><sub>8</sub><span title="Oxygen">O</span><sub>2</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002480532000000000♠"></span>480.532</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=Cc1cc%28Nc2ncnc3ccc%28NC4%3DNC%28C%29%28C%29CO4%29cc23%29ccc1Oc1ccn2ncnc2c1">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31)</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:SDEAXTCZPQIFQM-UHFFFAOYSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>Tucatinib</b>, sold under the brand name <b>Tukysa</b>, is an <a href="/wiki/Anticancer_medication" class="mw-redirect" title="Anticancer medication">anticancer medication</a> used for the treatment of <a href="/wiki/HER2-positive_breast_cancer" class="mw-redirect" title="HER2-positive breast cancer">HER2-positive breast cancer</a>.<sup id="cite_ref-Tukysa_FDA_label_3-1" class="reference"><a href="#cite_note-Tukysa_FDA_label-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Tukysa_EPAR_4-1" class="reference"><a href="#cite_note-Tukysa_EPAR-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> It is a small molecule inhibitor of <a href="/wiki/HER2" title="HER2">HER2</a>.<sup id="cite_ref-Levitan2025-Ph1_6-0" class="reference"><a href="#cite_note-Levitan2025-Ph1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It was developed by <a href="/wiki/Array_BioPharma" title="Array BioPharma">Array BioPharma</a> and licensed to Cascadian Therapeutics (formerly Oncothyreon, subsequently part of <a href="/wiki/Seattle_Genetics" class="mw-redirect" title="Seattle Genetics">Seattle Genetics</a>).<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Common side effects include diarrhea, palmar-plantar erythrodysesthesia (burning or tingling discomfort in the hands and feet), nausea, fatigue, hepatotoxicity (liver damage), vomiting, stomatitis (inflammation of the mouth and lips), decreased appetite, abdominal pain, headache, anemia and rash.<sup id="cite_ref-FDA_Tukysa_PR_9-0" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-0" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Tucatinib may cause harm to a developing fetus or baby.<sup id="cite_ref-FDA_Tukysa_PR_9-1" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Tucatinib was approved for medical use in the United States in April 2020,<sup id="cite_ref-FDA_Tukysa_PR_9-2" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-1" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_Drug_Approval_Package_11-0" class="reference"><a href="#cite_note-FDA_Drug_Approval_Package-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> in Australia in August 2020,<sup id="cite_ref-TGA_Tucatinib_1-1" class="reference"><a href="#cite_note-TGA_Tucatinib-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> and in the European Union in February 2021.<sup id="cite_ref-Tukysa_EPAR_4-2" class="reference"><a href="#cite_note-Tukysa_EPAR-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Tucatinib is a kinase inhibitor <a href="/wiki/Indication_(medicine)" title="Indication (medicine)">indicated</a> in combination with <a href="/wiki/Trastuzumab" title="Trastuzumab">trastuzumab</a> and <a href="/wiki/Capecitabine" title="Capecitabine">capecitabine</a> for the treatment of adults with advanced unresectable or metastatic HER2-positive breast cancer, including those with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting.<sup id="cite_ref-Tukysa_FDA_label_3-2" class="reference"><a href="#cite_note-Tukysa_FDA_label-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>In the European Union, it is indicated in combination with trastuzumab and capecitabine for the treatment of adults with HER2‑positive locally advanced or metastatic breast cancer who have received at least two prior anti‑HER2 treatment regimens.<sup id="cite_ref-Tukysa_EPAR_4-3" class="reference"><a href="#cite_note-Tukysa_EPAR-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>In January 2023, the US <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) granted accelerated approval to tucatinib in combination with trastuzumab for RAS wild-type HER2-positive unresectable or metastatic colorectal cancer that has progressed following fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_trials">Clinical trials</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=2" title="Edit section: Clinical trials"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Two early stage clinical trials have reported encouraging results, both of which had options to enroll subjects with central nervous system (CNS) metastases.<sup id="cite_ref-Levitan2025-Ph1_6-1" class="reference"><a href="#cite_note-Levitan2025-Ph1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PR-2015-12_13-0" class="reference"><a href="#cite_note-PR-2015-12-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Borges_2016_16-0" class="reference"><a href="#cite_note-Borges_2016-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> HER2CLIMB is a Phase 2 randomized, double-blinded, placebo-controlled study of tucatinib in combination with <a href="/wiki/Trastuzumab" title="Trastuzumab">trastuzumab</a> and <a href="/wiki/Capecitabine" title="Capecitabine">capecitabine</a> in patients with pretreated, unresectable locally advanced or metastatic HER2-positive breast cancer.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=3" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In April 2020, the U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) approved tucatinib in combination with chemotherapy (<a href="/wiki/Trastuzumab" title="Trastuzumab">trastuzumab</a> and <a href="/wiki/Capecitabine" title="Capecitabine">capecitabine</a>) for the treatment of adults with advanced forms of <a href="/wiki/HER2-positive_breast_cancer" class="mw-redirect" title="HER2-positive breast cancer">HER2-positive breast cancer</a> that can't be removed with surgery, or has spread to other parts of the body, including the brain, and who have received one or more prior treatments.<sup id="cite_ref-FDA_Tukysa_PR_9-3" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-2" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p><p>The FDA collaborated with the Australian <a href="/wiki/Therapeutic_Goods_Administration" title="Therapeutic Goods Administration">Therapeutic Goods Administration</a> (TGA), <a href="/wiki/Health_Canada" title="Health Canada">Health Canada</a>, <a href="/wiki/Health_Sciences_Authority" title="Health Sciences Authority">Health Sciences Authority</a> (HSA, Singapore) and <a href="/wiki/Swissmedic" title="Swissmedic">Swissmedic</a> (SMC, Switzerland) on the review.<sup id="cite_ref-FDA_Tukysa_PR_9-4" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> This was the first <a href="/w/index.php?title=Project_Orbis&action=edit&redlink=1" class="new" title="Project Orbis (page does not exist)">Project Orbis</a> partnership between the FDA, HSA and Swissmedic.<sup id="cite_ref-FDA_Tukysa_PR_9-5" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> As of 17 April 2020<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Tucatinib&action=edit">[update]</a></sup>, the application is still under review at the other agencies.<sup id="cite_ref-FDA_Tukysa_PR_9-6" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Tucatinib is a <a href="/wiki/Kinase_inhibitor" class="mw-redirect" title="Kinase inhibitor">kinase inhibitor</a> meaning it blocks a type of enzyme (kinase) and helps prevent the cancer cells from growing.<sup id="cite_ref-FDA_Tukysa_PR_9-7" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Tucatinib is approved for treatment after adults have taken one or more anti-HER2-based regimens in the metastatic setting.<sup id="cite_ref-FDA_Tukysa_PR_9-8" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The FDA approved tucatinib based on the results of the HER2CLIMB trial (NCT02614794) enrolling 612 subjects who had HER2-positive advanced unresectable or <a href="/wiki/Metastatic_breast_cancer" title="Metastatic breast cancer">metastatic breast cancer</a> and had prior treatment with <a href="/wiki/Trastuzumab" title="Trastuzumab">trastuzumab</a>, <a href="/wiki/Pertuzumab" title="Pertuzumab">pertuzumab</a> and <a href="/wiki/Ado-trastuzumab_emtansine" class="mw-redirect" title="Ado-trastuzumab emtansine">ado-trastuzumab emtansine</a> (T-DM1).<sup id="cite_ref-FDA_Tukysa_PR_9-9" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-3" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Subjects with previously treated and stable brain metastases, as well as those with previously treated and growing or untreated brain metastases, were eligible for the clinical trial, and 48% of enrolled subjects had brain metastases at the start of the trial.<sup id="cite_ref-FDA_Tukysa_PR_9-10" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Subjects received either tucatinib 300<span class="nowrap"> </span>mg twice daily plus trastuzumab and capecitabine (tucatinib arm, n=410) or placebo plus trastuzumab and capecitabine (control arm, n=202).<sup id="cite_ref-FDA_approval_10-4" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The primary endpoint was progression-free survival (PFS), or the amount of time when there was no growth of the tumor, assessed by a blinded independent central review, evaluated in the initial 480 randomized patients.<sup id="cite_ref-FDA_Tukysa_PR_9-11" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-5" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The median PFS in subjects who received tucatinib, trastuzumab, and capecitabine was 7.8 months (95% CI: 7.5, 9.6) compared to 5.6 months (95% CI: 4.2, 7.1) in those subjects who received placebo, trastuzumab, and capecitabine (HR 0.54; 95% CI: 0.42, 0.71; p<0.00001).<sup id="cite_ref-FDA_Tukysa_PR_9-12" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-6" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Overall survival and PFS in subjects with brain metastases at baseline were key secondary endpoints.<sup id="cite_ref-FDA_Tukysa_PR_9-13" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The median overall survival in subjects who received tucatinib, trastuzumab, and capecitabine was 21.9 months (95% CI: 18.3, 31.0) compared to 17.4 months (95% CI: 13.6, 19.9) in subjects who received placebo, trastuzumab, and capecitabine (HR: 0.66; 95% CI: 0.50, 0.87; p=0.00480).<sup id="cite_ref-FDA_Tukysa_PR_9-14" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-7" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The median PFS in subjects with brain metastases at baseline who received tucatinib, trastuzumab and capecitabine was 7.6 months (95% CI: 6.2, 9.5) compared to 5.4 months (95% CI: 4.1, 5.7) in subjects who received placebo, trastuzumab and capecitabine (HR: 0.48; 0.34, 0.69; p<0.00001).<sup id="cite_ref-FDA_Tukysa_PR_9-15" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-8" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>The FDA granted the application for tucatinib <a href="/wiki/Priority_review" title="Priority review">priority review</a>, <a href="/wiki/Breakthrough_therapy" title="Breakthrough therapy">breakthrough therapy</a>, <a href="/wiki/Fast_track_(FDA)" title="Fast track (FDA)">fast track</a>, and <a href="/wiki/Orphan_drug" title="Orphan drug">orphan drug</a> designations.<sup id="cite_ref-FDA_Tukysa_PR_9-16" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-9" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> The FDA granted approval of Tukysa to Seattle Genetics, Inc.<sup id="cite_ref-FDA_Tukysa_PR_9-17" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=4" title="Edit section: Society and culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Economics">Economics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=5" title="Edit section: Economics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Tucatinib was denied entry into the Australian <a href="/wiki/Pharmaceutical_Benefits_Scheme" title="Pharmaceutical Benefits Scheme">Pharmaceutical Benefits Scheme</a> in March 2021, as "the incremental cost effectiveness ratio was unacceptably high at the proposed price".<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Legal_status">Legal status</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=6" title="Edit section: Legal status"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Tucatinib was approved for medical use in the United States in April 2020.<sup id="cite_ref-FDA_Tukysa_PR_9-18" class="reference"><a href="#cite_note-FDA_Tukysa_PR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_10-10" class="reference"><a href="#cite_note-FDA_approval-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_Drug_Approval_Package_11-1" class="reference"><a href="#cite_note-FDA_Drug_Approval_Package-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>Tucatinib was approved for medical use in Australia in August 2020.<sup id="cite_ref-TGA_Tucatinib_1-2" class="reference"><a href="#cite_note-TGA_Tucatinib-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>On 10 December 2020, the <a href="/wiki/Committee_for_Medicinal_Products_for_Human_Use" title="Committee for Medicinal Products for Human Use">Committee for Medicinal Products for Human Use</a> (CHMP) of the <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Tukysa, intended for the treatment of HER2-positive locally advanced or metastatic breast cancer.<sup id="cite_ref-Tukysa:_Pending_EC_decision_21-0" class="reference"><a href="#cite_note-Tukysa:_Pending_EC_decision-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> The applicant for this medicinal product is Seagen B.V.<sup id="cite_ref-Tukysa:_Pending_EC_decision_21-1" class="reference"><a href="#cite_note-Tukysa:_Pending_EC_decision-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Tucatinib was approved for medical use in the European Union in February 2021.<sup id="cite_ref-Tukysa_EPAR_4-4" class="reference"><a href="#cite_note-Tukysa_EPAR-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Names">Names</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=7" title="Edit section: Names"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Tucatinib is the <a href="/wiki/International_nonproprietary_name" title="International nonproprietary name">International nonproprietary name</a>.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=8" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-TGA_Tucatinib-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-TGA_Tucatinib_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-TGA_Tucatinib_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-TGA_Tucatinib_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.tga.gov.au/apm-summary/tukysa">"Tukysa"</a>. <i><a href="/wiki/Therapeutic_Goods_Administration" title="Therapeutic Goods Administration">Therapeutic Goods Administration</a> (TGA)</i>. 21 August 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20201001185402/https://www.tga.gov.au/apm-summary/tukysa">Archived</a> from the original on 1 October 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">22 September</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Therapeutic+Goods+Administration+%28TGA%29&rft.atitle=Tukysa&rft.date=2020-08-21&rft_id=https%3A%2F%2Fwww.tga.gov.au%2Fapm-summary%2Ftukysa&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?linkID=SBD00498&lang=en">"Summary Basis of Decision (SBD) for Tukysa"</a>. <i>Health Canada</i>. 23 October 2014. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220530053927/https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?linkID=SBD00498&lang=en">Archived</a> from the original on 30 May 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">29 May</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Health+Canada&rft.atitle=Summary+Basis+of+Decision+%28SBD%29+for+Tukysa&rft.date=2014-10-23&rft_id=https%3A%2F%2Fhpr-rps.hres.ca%2Freg-content%2Fsummary-basis-decision-detailTwo.php%3FlinkID%3DSBD00498%26lang%3Den&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-Tukysa_FDA_label-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-Tukysa_FDA_label_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Tukysa_FDA_label_3-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Tukysa_FDA_label_3-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f27eb1b9-b7fc-424e-988f-84dd7bb195a3">"Tukysa- tucatinib tablet"</a>. <i>DailyMed</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210128180346/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f27eb1b9-b7fc-424e-988f-84dd7bb195a3">Archived</a> from the original on 28 January 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">21 January</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Tukysa-+tucatinib+tablet&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3Df27eb1b9-b7fc-424e-988f-84dd7bb195a3&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-Tukysa_EPAR-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-Tukysa_EPAR_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Tukysa_EPAR_4-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Tukysa_EPAR_4-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Tukysa_EPAR_4-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Tukysa_EPAR_4-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/EPAR/tukysa">"Tukysa EPAR"</a>. <i><a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA)</i>. 9 December 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210322093102/https://www.ema.europa.eu/en/medicines/human/EPAR/tukysa">Archived</a> from the original on 22 March 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">18 February</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=European+Medicines+Agency+%28EMA%29&rft.atitle=Tukysa+EPAR&rft.date=2020-12-09&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2FEPAR%2Ftukysa&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://ec.europa.eu/health/documents/community-register/html/h1526.htm">"Tukysa Product information"</a>. <i>Union Register of medicinal products</i><span class="reference-accessdate">. Retrieved <span class="nowrap">3 March</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Union+Register+of+medicinal+products&rft.atitle=Tukysa+Product+information&rft_id=https%3A%2F%2Fec.europa.eu%2Fhealth%2Fdocuments%2Fcommunity-register%2Fhtml%2Fh1526.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-Levitan2025-Ph1-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-Levitan2025-Ph1_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Levitan2025-Ph1_6-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.cancernetwork.com/news/ont-380-active-against-cns-mets-her2-positive-breast-cancer">"ONT-380 Active Against CNS Mets in HER2-Positive Breast Cancer"</a>. <i>Cancer Network</i>. 15 December 2015<span class="reference-accessdate">. Retrieved <span class="nowrap">17 April</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Cancer+Network&rft.atitle=ONT-380+Active+Against+CNS+Mets+in+HER2-Positive+Breast+Cancer&rft.date=2015-12-15&rft_id=https%3A%2F%2Fwww.cancernetwork.com%2Fnews%2Font-380-active-against-cns-mets-her2-positive-breast-cancer&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/Wikipedia:Link_rot" title="Wikipedia:Link rot"><span title=" Dead link tagged March 2023">permanent dead link</span></a></i><span style="visibility:hidden; color:transparent; padding-left:2px">‍</span>]</span></sup></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMartinLópez-Tarruella2018" class="citation journal cs1">Martin M, López-Tarruella S (October 2018). <a rel="nofollow" class="external text" href="https://doi.org/10.1200%2FEDBK_159167">"Emerging Therapeutic Options for HER2-Positive Breast Cancer"</a>. <i>American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting</i>. <b>35</b> (36): e64–70. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1200%2FEDBK_159167">10.1200/EDBK_159167</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27249772">27249772</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=American+Society+of+Clinical+Oncology+Educational+Book.+American+Society+of+Clinical+Oncology.+Annual+Meeting&rft.atitle=Emerging+Therapeutic+Options+for+HER2-Positive+Breast+Cancer&rft.volume=35&rft.issue=36&rft.pages=e64-70&rft.date=2018-10&rft_id=info%3Adoi%2F10.1200%2FEDBK_159167&rft_id=info%3Apmid%2F27249772&rft.aulast=Martin&rft.aufirst=M&rft.au=L%C3%B3pez-Tarruella%2C+S&rft_id=https%3A%2F%2Fdoi.org%2F10.1200%252FEDBK_159167&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://searchusan.ama-assn.org/usan/documentDownload?uri=%2Funstructured%2Fbinary%2Fusan%2Ftucatinib.pdf">"Tucatinib"</a> <span class="cs1-format">(PDF)</span>. <i>Statement on a Nonproprietary Name Adopted by the USAN Council</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210827165916/https://searchusan.ama-assn.org/usan/documentDownload?uri=%2Funstructured%2Fbinary%2Fusan%2Ftucatinib.pdf">Archived</a> <span class="cs1-format">(PDF)</span> from the original on 27 August 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">31 January</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Statement+on+a+Nonproprietary+Name+Adopted+by+the+USAN+Council&rft.atitle=Tucatinib&rft_id=https%3A%2F%2Fsearchusan.ama-assn.org%2Fusan%2FdocumentDownload%3Furi%3D%252Funstructured%252Fbinary%252Fusan%252Ftucatinib.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-FDA_Tukysa_PR-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_Tukysa_PR_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-16"><sup><i><b>q</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-17"><sup><i><b>r</b></i></sup></a> <a href="#cite_ref-FDA_Tukysa_PR_9-18"><sup><i><b>s</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/news-events/press-announcements/fda-approves-first-new-drug-under-international-collaboration-treatment-option-patients-her2">"FDA Approves First New Drug Under International Collaboration, A Treatment Option for Patients with HER2-Positive Metastatic Breast Cancer"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i> (Press release). 17 April 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200417201825/https://www.fda.gov/news-events/press-announcements/fda-approves-first-new-drug-under-international-collaboration-treatment-option-patients-her2">Archived</a> from the original on 17 April 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">17 April</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=FDA+Approves+First+New+Drug+Under+International+Collaboration%2C+A+Treatment+Option+for+Patients+with+HER2-Positive+Metastatic+Breast+Cancer&rft.date=2020-04-17&rft_id=https%3A%2F%2Fwww.fda.gov%2Fnews-events%2Fpress-announcements%2Ffda-approves-first-new-drug-under-international-collaboration-treatment-option-patients-her2&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-FDA_approval-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_approval_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-FDA_approval_10-10"><sup><i><b>k</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-tucatinib-patients-her2-positive-metastatic-breast-cancer">"FDA approves tucatinib for patients with HER2-positive metastatic brea"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 17 April 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200421025651/https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-tucatinib-patients-her2-positive-metastatic-breast-cancer">Archived</a> from the original on 21 April 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">20 April</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=FDA+approves+tucatinib+for+patients+with+HER2-positive+metastatic+brea&rft.date=2020-04-17&rft_id=https%3A%2F%2Fwww.fda.gov%2Fdrugs%2Fresources-information-approved-drugs%2Ffda-approves-tucatinib-patients-her2-positive-metastatic-breast-cancer&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-FDA_Drug_Approval_Package-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_Drug_Approval_Package_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_Drug_Approval_Package_11-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/213411Orig1s000TOC.cfm">"Drug Approval Package: Tukysa"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 18 May 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210128050119/https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/213411Orig1s000TOC.cfm">Archived</a> from the original on 28 January 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">21 January</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Drug+Approval+Package%3A+Tukysa&rft.date=2020-05-18&rft_id=https%3A%2F%2Fwww.accessdata.fda.gov%2Fdrugsatfda_docs%2Fnda%2F2020%2F213411Orig1s000TOC.cfm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-tucatinib-trastuzumab-colorectal-cancer">"FDA grants accelerated approval to tucatinib with trastuzumab for colorectal cancer"</a>. U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA). 19 January 2023. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20230125204721/https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-tucatinib-trastuzumab-colorectal-cancer">Archived</a> from the original on 25 January 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">26 January</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=FDA+grants+accelerated+approval+to+tucatinib+with+trastuzumab+for+colorectal+cancer&rft.pub=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.date=2023-01-19&rft_id=https%3A%2F%2Fwww.fda.gov%2Fdrugs%2Fresources-information-approved-drugs%2Ffda-grants-accelerated-approval-tucatinib-trastuzumab-colorectal-cancer&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-PR-2015-12-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-PR-2015-12_13-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.biospace.com/article/oncothyreon-inc-announces-data-for-ont-380-in-her2-positive-breast-cancer-patients-with-and-without-brain-metastases-at-the-b-san-antonio-breast-can/">"Oncothyreon Inc. Announces Data For ONT-380 In HER2-Positive Breast Cancer Patients With And Without Brain Metastases At The San Antonio Breast Cancer Symposium"</a>. <i>BioSpace</i> (Press release). 9 December 2015. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210827165921/https://www.biospace.com/article/oncothyreon-inc-announces-data-for-ont-380-in-her2-positive-breast-cancer-patients-with-and-without-brain-metastases-at-the-b-san-antonio-breast-can/">Archived</a> from the original on 27 August 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">18 April</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Oncothyreon+Inc.+Announces+Data+For+ONT-380+In+HER2-Positive+Breast+Cancer+Patients+With+And+Without+Brain+Metastases+At+The+San+Antonio+Breast+Cancer+Symposium&rft.date=2015-12-09&rft_id=https%3A%2F%2Fwww.biospace.com%2Farticle%2Foncothyreon-inc-announces-data-for-ont-380-in-her2-positive-breast-cancer-patients-with-and-without-brain-metastases-at-the-b-san-antonio-breast-can%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.coloradocancerblogs.org/ont-380-san-antonio/">"SABCS15: Promising phase 1 results lead to phase 2 for ONT-380 in HER2+ breast cancer"</a>. <i>Colorado Cancer Blogs</i>. 9 December 2015. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200418171644/https://coloradocancerblogs.org/ont-380-san-antonio/">Archived</a> from the original on 18 April 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">10 June</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Colorado+Cancer+Blogs&rft.atitle=SABCS15%3A+Promising+phase+1+results+lead+to+phase+2+for+ONT-380+in+HER2%2B+breast+cancer&rft.date=2015-12-09&rft_id=http%3A%2F%2Fwww.coloradocancerblogs.org%2Font-380-san-antonio%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/NCT02025192">"A Study of Tucatinib (ONT-380) Combined With Capecitabine and/or Trastuzumab in Patients With HER2+ Metastatic Breast Cancer"</a>. <i>ClinicalTrials.gov</i>. 31 December 2013. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190806125737/https://clinicaltrials.gov/ct2/show/NCT02025192">Archived</a> from the original on 6 August 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">18 April</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinicalTrials.gov&rft.atitle=A+Study+of+Tucatinib+%28ONT-380%29+Combined+With+Capecitabine+and%2For+Trastuzumab+in+Patients+With+HER2%2B+Metastatic+Breast+Cancer&rft.date=2013-12-31&rft_id=https%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT02025192&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-Borges_2016-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-Borges_2016_16-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBorgesFerrarioAucoinFalkson" class="citation journal cs1">Borges VF, Ferrario C, Aucoin N, Falkson CI, Khan QJ, Krop IE, et al. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170510094416/http://meetinglibrary.asco.org/content/170543-176">"Efficacy results of a phase 1b study of ONT-380, a CNS-penetrant TKI, in combination with T-DM1 in HER2+ metastatic breast cancer (MBC), including patients (pts) with brain metastases"</a>. <i>Journal of Clinical Oncology</i>. 2016 ASCO Annual Meeting. Archived from <a rel="nofollow" class="external text" href="http://meetinglibrary.asco.org/content/170543-176">the original</a> on 10 May 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">6 August</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Efficacy+results+of+a+phase+1b+study+of+ONT-380%2C+a+CNS-penetrant+TKI%2C+in+combination+with+T-DM1+in+HER2%2B+metastatic+breast+cancer+%28MBC%29%2C+including+patients+%28pts%29+with+brain+metastases.&rft.aulast=Borges&rft.aufirst=VF&rft.au=Ferrario%2C+C&rft.au=Aucoin%2C+N&rft.au=Falkson%2C+CI&rft.au=Khan%2C+QJ&rft.au=Krop%2C+IE&rft.au=Welch%2C+S&rft.au=Bedard%2C+PL&rft.au=Conlin%2C+AK&rft.au=Chaves%2C+J&rft.au=Walker%2C+LN&rft_id=http%3A%2F%2Fmeetinglibrary.asco.org%2Fcontent%2F170543-176&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/NCT02614794">"A Study of Tucatinib vs. Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer (HER2CLIMB)"</a>. <i>ClinicalTrials.gov</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200430134242/https://clinicaltrials.gov/ct2/show/NCT02614794">Archived</a> from the original on 30 April 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">18 April</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinicalTrials.gov&rft.atitle=A+Study+of+Tucatinib+vs.+Placebo+in+Combination+With+Capecitabine+%26+Trastuzumab+in+Patients+With+Advanced+HER2%2B+Breast+Cancer+%28HER2CLIMB%29&rft_id=https%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT02614794&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=213411">"Tukysa: FDA-Approved Drugs"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200919035345/https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=213411">Archived</a> from the original on 19 September 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">20 April</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Tukysa%3A+FDA-Approved+Drugs&rft_id=https%3A%2F%2Fwww.accessdata.fda.gov%2Fscripts%2Fcder%2Fdaf%2Findex.cfm%3Fevent%3Doverview.process%26ApplNo%3D213411&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=570716">"Tucatinib Orphan Drug Designation and Approval"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 24 December 1999. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200904152623/https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=570716">Archived</a> from the original on 4 September 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">20 April</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Tucatinib+Orphan+Drug+Designation+and+Approval&rft.date=1999-12-24&rft_id=https%3A%2F%2Fwww.accessdata.fda.gov%2Fscripts%2Fopdlisting%2Foopd%2FdetailedIndex.cfm%3Fcfgridkey%3D570716&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.pbs.gov.au/industry/listing/elements/pbac-meetings/pbac-outcomes/2021-03/march-2021-pbac-web-outcomes.pdf">"Recommendations made by the PBAC – March 2021"</a> <span class="cs1-format">(PDF)</span>. Australian Government Department of Health. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210426044227/https://www.pbs.gov.au/industry/listing/elements/pbac-meetings/pbac-outcomes/2021-03/march-2021-pbac-web-outcomes.pdf">Archived</a> <span class="cs1-format">(PDF)</span> from the original on 26 April 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">24 May</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Recommendations+made+by+the+PBAC+%E2%80%93+March+2021&rft.pub=Australian+Government+Department+of+Health&rft_id=https%3A%2F%2Fwww.pbs.gov.au%2Findustry%2Flisting%2Felements%2Fpbac-meetings%2Fpbac-outcomes%2F2021-03%2Fmarch-2021-pbac-web-outcomes.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> <li id="cite_note-Tukysa:_Pending_EC_decision-21"><span class="mw-cite-backlink">^ <a href="#cite_ref-Tukysa:_Pending_EC_decision_21-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Tukysa:_Pending_EC_decision_21-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20201212021312/https://www.ema.europa.eu/en/medicines/human/summaries-opinion/tukysa">"Tukysa: Pending EC decision"</a>. <i><a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA)</i>. 10 December 2020. Archived from <a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/summaries-opinion/tukysa">the original</a> on 12 December 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">11 December</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=European+Medicines+Agency+%28EMA%29&rft.atitle=Tukysa%3A+Pending+EC+decision&rft.date=2020-12-10&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2Fsummaries-opinion%2Ftukysa&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-22">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWorld_Health_Organization2016" class="citation journal cs1">World Health Organization (2016). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 75". <i>WHO Drug Information</i>. <b>30</b> (1): 161. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/10665%2F331046">10665/331046</a></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=WHO+Drug+Information&rft.atitle=International+nonproprietary+names+for+pharmaceutical+substances+%28INN%29%3A+recommended+INN%3A+list+75&rft.volume=30&rft.issue=1&rft.pages=161&rft.date=2016&rft_id=info%3Ahdl%2F10665%2F331046&rft.au=World+Health+Organization&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tucatinib&action=edit&section=9" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tucatinib">"Tucatinib"</a>. <i>NCI Drug Dictionary</i>. National Cancer Institute.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NCI+Drug+Dictionary&rft.atitle=Tucatinib&rft_id=https%3A%2F%2Fwww.cancer.gov%2Fpublications%2Fdictionaries%2Fcancer-drug%2Fdef%2Ftucatinib&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/tucatinib">"Tucatinib"</a>. <i>NCI Dictionary of Cancer Terms</i>. National Cancer Institute.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NCI+Dictionary+of+Cancer+Terms&rft.atitle=Tucatinib&rft_id=https%3A%2F%2Fwww.cancer.gov%2Fpublications%2Fdictionaries%2Fcancer-terms%2Fdef%2Ftucatinib&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATucatinib" class="Z3988"></span></li> <li>Clinical trial number <i><a rel="nofollow" class="external text" href="https://www.clinicaltrials.gov/show/NCT02614794">NCT02614794</a></i> for "A Study of Tucatinib vs. Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer (HER2CLIMB)" at <a href="/wiki/ClinicalTrials.gov" title="ClinicalTrials.gov">ClinicalTrials.gov</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Targeted_cancer_therapy_/_antineoplastic_agents_(L01)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Targeted_cancer_therapeutic_agents" title="Template:Targeted cancer therapeutic agents"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Targeted_cancer_therapeutic_agents" title="Template talk:Targeted cancer therapeutic agents"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Targeted_cancer_therapeutic_agents" title="Special:EditPage/Template:Targeted cancer therapeutic agents"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Targeted_cancer_therapy_/_antineoplastic_agents_(L01)" style="font-size:114%;margin:0 4em"><a href="/wiki/Targeted_cancer_therapy" class="mw-redirect" title="Targeted cancer therapy">Targeted cancer therapy</a> / <a href="/wiki/Antineoplastic" class="mw-redirect" title="Antineoplastic">antineoplastic agents</a> (<a href="/wiki/ATC_code_L01" title="ATC code L01">L01</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cancer_immunotherapy" title="Cancer immunotherapy">CI</a> <a href="/wiki/Monoclonal_antibody_therapy" title="Monoclonal antibody therapy">monoclonal antibodies</a> ("-mab")</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Receptor tyrosine kinase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ErbB" title="ErbB">ErbB</a>: <i><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">HER1/EGFR</a></i> (<a href="/wiki/Cetuximab" title="Cetuximab">Cetuximab</a></li> <li><a href="/wiki/Panitumumab" title="Panitumumab">Panitumumab</a>)</li> <li><i><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">HER2/neu</a></i> (<a href="/wiki/Pertuzumab" title="Pertuzumab">Pertuzumab</a></li> <li><a href="/wiki/Trastuzumab" title="Trastuzumab">Trastuzumab</a> (<a href="/wiki/Trastuzumab/hyaluronidase" title="Trastuzumab/hyaluronidase">+hyaluronidase</a>)</li> <li><a href="/wiki/Trastuzumab_emtansine" title="Trastuzumab emtansine">Trastuzumab emtansine</a></li> <li><a href="/wiki/Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">Trastuzumab deruxtecan</a></li> <li><a href="/wiki/Zanidatamab" title="Zanidatamab">Zanidatamab</a> )</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others for solid tumors</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/EpCAM" class="mw-redirect" title="EpCAM">EpCAM</a></i> (<a href="/wiki/Catumaxomab" title="Catumaxomab">Catumaxomab</a></li> <li><a href="/wiki/Edrecolomab" title="Edrecolomab">Edrecolomab</a>)</li> <li><i><a href="/wiki/Vascular_endothelial_growth_factor_A" title="Vascular endothelial growth factor A">VEGF-A</a></i> (<a href="/wiki/Bevacizumab" title="Bevacizumab">Bevacizumab</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leukemia" title="Leukemia">Leukemia</a>/<a href="/wiki/Lymphoma" title="Lymphoma">lymphoma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphatic_system" title="Lymphatic system">lymphoid</a>: <i><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a></i> (<a href="/wiki/Glofitamab" title="Glofitamab">Glofitamab</a>, <a href="/wiki/Elranatamab" title="Elranatamab">Elranatamab</a>, <a href="/wiki/Mosunetuzumab" title="Mosunetuzumab">Mosunetuzumab</a>), <i><a href="/wiki/CD20" title="CD20">CD20</a></i> (<a href="/wiki/Glofitamab" title="Glofitamab">Glofitamab</a></li> <li><a href="/wiki/Ibritumomab_tiuxetan" title="Ibritumomab tiuxetan">Ibritumomab</a></li> <li><a href="/wiki/Mosunetuzumab" title="Mosunetuzumab">Mosunetuzumab</a></li> <li><a href="/wiki/Obinutuzumab" title="Obinutuzumab">Obinutuzumab</a></li> <li><a href="/wiki/Ofatumumab" title="Ofatumumab">Ofatumumab</a></li> <li><a href="/wiki/Rituximab" title="Rituximab">Rituximab</a></li> <li><a href="/wiki/Tositumomab" title="Tositumomab">Tositumomab</a>), <i><a href="/wiki/CD30" title="CD30">CD30</a></i> (<a href="/wiki/Brentuximab_vedotin" title="Brentuximab vedotin">Brentuximab</a>), <i><a href="/wiki/CD52" title="CD52">CD52</a></i> (<a href="/wiki/Alemtuzumab" title="Alemtuzumab">Alemtuzumab</a>)</li></ul> <ul><li><a href="/wiki/Myeloid" class="mw-redirect" title="Myeloid">myeloid</a>: <i><a href="/wiki/CD33" title="CD33">CD33</a></i> (<a href="/wiki/Gemtuzumab_ozogamicin" title="Gemtuzumab ozogamicin">Gemtuzumab ozogamicin</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amivantamab" title="Amivantamab">Amivantamab</a></li> <li><a href="/wiki/Atezolizumab" title="Atezolizumab">Atezolizumab</a> (<a href="/wiki/Atezolizumab/hyaluronidase" title="Atezolizumab/hyaluronidase">+hyaluronidase</a>)</li> <li><a href="/wiki/Avelumab" title="Avelumab">Avelumab</a></li> <li><a href="/wiki/Axatilimab" title="Axatilimab">Axatilimab</a></li> <li><a href="/wiki/Belantamab_mafodotin" title="Belantamab mafodotin">Belantamab mafodotin</a></li> <li><a href="/wiki/Bermekimab" title="Bermekimab">Bermekimab</a></li> <li><a href="/wiki/Blinatumomab" title="Blinatumomab">Blinatumomab</a></li> <li><a href="/wiki/Cemiplimab" title="Cemiplimab">Cemiplimab</a></li> <li><a href="/wiki/Daratumumab" title="Daratumumab">Daratumumab</a></li> <li><a href="/wiki/Dinutuximab_beta" class="mw-redirect" title="Dinutuximab beta">Dinutuximab beta</a></li> <li><a href="/wiki/Dostarlimab" title="Dostarlimab">Dostarlimab</a></li> <li><a href="/wiki/Durvalumab" title="Durvalumab">Durvalumab</a></li> <li><a href="/wiki/Elotuzumab" title="Elotuzumab">Elotuzumab</a></li> <li><a href="/wiki/Enfortumab_vedotin" title="Enfortumab vedotin">Enfortumab vedotin</a></li> <li><a href="/wiki/Epcoritamab" title="Epcoritamab">Epcoritamab</a></li> <li><a href="/wiki/Inotuzumab_ozogamicin" title="Inotuzumab ozogamicin">Inotuzumab ozogamicin</a></li> <li><a href="/wiki/Ipilimumab" title="Ipilimumab">Ipilimumab</a></li> <li><a href="/wiki/Isatuximab" title="Isatuximab">Isatuximab</a></li> <li><a href="/wiki/Loncastuximab_tesirine" title="Loncastuximab tesirine">Loncastuximab tesirine</a></li> <li><a href="/wiki/Mirvetuximab_soravtansine" title="Mirvetuximab soravtansine">Mirvetuximab soravtansine</a></li> <li><a href="/wiki/Mogamulizumab" title="Mogamulizumab">Mogamulizumab</a></li> <li><a href="/wiki/Moxetumomab_pasudotox" title="Moxetumomab pasudotox">Moxetumomab pasudotox</a></li> <li><a href="/wiki/Naxitamab" title="Naxitamab">Naxitamab</a></li> <li><a href="/wiki/Necitumumab" title="Necitumumab">Necitumumab</a></li> <li><a href="/wiki/Nivolumab" title="Nivolumab">Nivolumab</a></li> <li><a href="/wiki/Olaratumab" title="Olaratumab">Olaratumab</a></li> <li><a href="/wiki/Oportuzumab_monatox" title="Oportuzumab monatox">Oportuzumab monatox</a></li> <li><a href="/wiki/Pembrolizumab" title="Pembrolizumab">Pembrolizumab</a></li> <li><a href="/wiki/Polatuzumab_vedotin" title="Polatuzumab vedotin">Polatuzumab vedotin</a></li> <li><a href="/w/index.php?title=Prolgolimab&action=edit&redlink=1" class="new" title="Prolgolimab (page does not exist)">Prolgolimab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Retifanlimab" title="Retifanlimab">Retifanlimab</a></li> <li><a href="/w/index.php?title=Sabatolimab&action=edit&redlink=1" class="new" title="Sabatolimab (page does not exist)">Sabatolimab</a></li> <li><a href="/wiki/Sacituzumab_govitecan" title="Sacituzumab govitecan">Sacituzumab govitecan</a></li> <li><a href="/wiki/Serplulimab" title="Serplulimab">Serplulimab</a></li> <li><a href="/wiki/Sugemalimab" title="Sugemalimab">Sugemalimab</a></li> <li><a href="/wiki/Tafasitamab" title="Tafasitamab">Tafasitamab</a></li> <li><a href="/wiki/Talquetamab" title="Talquetamab">Talquetamab</a></li> <li><a href="/wiki/Tarlatamab" title="Tarlatamab">Tarlatamab</a></li> <li><a href="/wiki/Teclistamab" title="Teclistamab">Teclistamab</a></li> <li><a href="/wiki/Tislelizumab" title="Tislelizumab">Tislelizumab</a></li> <li><a href="/wiki/Tisotumab_vedotin" title="Tisotumab vedotin">Tisotumab vedotin</a></li> <li><a href="/wiki/Toripalimab" title="Toripalimab">Toripalimab</a></li> <li><a href="/wiki/Tremelimumab" title="Tremelimumab">Tremelimumab</a></li> <li><a href="/wiki/Zolbetuximab" title="Zolbetuximab">Zolbetuximab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine_kinase_inhibitor" title="Tyrosine kinase inhibitor">Tyrosine kinase inhibitors</a> ("-nib")</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Receptor tyrosine kinase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ErbB" title="ErbB">ErbB</a>: <i><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">HER1/EGFR</a></i> (<a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/wiki/Aumolertinib" title="Aumolertinib">Aumolertinib</a></li> <li><a href="/wiki/Brigatinib" title="Brigatinib">Brigatinib</a></li> <li><a href="/wiki/Dacomitinib" title="Dacomitinib">Dacomitinib</a></li> <li><a href="/wiki/Erlotinib" title="Erlotinib">Erlotinib</a></li> <li><a href="/wiki/Gefitinib" title="Gefitinib">Gefitinib</a></li> <li><a href="/wiki/Icotinib" title="Icotinib">Icotinib</a></li> <li><a href="/wiki/Lazertinib" title="Lazertinib">Lazertinib</a></li> <li><a href="/wiki/Mobocertinib" title="Mobocertinib">Mobocertinib</a></li> <li><a href="/wiki/Olmutinib" title="Olmutinib">Olmutinib</a></li> <li><a href="/wiki/Osimertinib" title="Osimertinib">Osimertinib</a></li> <li><a href="/wiki/Rociletinib" title="Rociletinib">Rociletinib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a>)</li></ul> <ul><li><i>HER1/EGFR and <a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">HER2/neu</a></i> <ul><li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a class="mw-selflink selflink">Tucatinib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/BRAF_(gene)" title="BRAF (gene)">BRAF</a></i> <ul><li><a href="/wiki/Dabrafenib" title="Dabrafenib">Dabrafenib</a></li> <li><a href="/wiki/Encorafenib" title="Encorafenib">Encorafenib</a></li> <li><a href="/wiki/Vemurafenib" title="Vemurafenib">Vemurafenib</a></li></ul></li></ul> <ul><li><a href="/wiki/RTK_class_III" title="RTK class III">RTK class III</a>: <i><a href="/wiki/CD117" class="mw-redirect" title="CD117">C-kit</a> and <a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGFR</a></i> (<a href="/wiki/Avapritinib" title="Avapritinib">Avapritinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a>)</li> <li><i><a href="/wiki/CD135" title="CD135">FLT3</a></i> (<a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a>, <a href="/wiki/Gilteritinib" title="Gilteritinib">Gilteritinib</a> (AXL, ALK, LTK))</li></ul> <ul><li><i><a href="/wiki/VEGF_receptors" class="mw-redirect" title="VEGF receptors">VEGFR</a></i> <ul><li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Cediranib" title="Cediranib">Cediranib</a></li> <li><a href="/wiki/Fruquintinib" title="Fruquintinib">Fruquintinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Regorafenib" title="Regorafenib">Regorafenib</a></li> <li><a href="/wiki/Semaxanib" title="Semaxanib">Semaxanib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Tivozanib" title="Tivozanib">Tivozanib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">ALK</a></i> <ul><li><a href="/wiki/Alectinib" title="Alectinib">Alectinib</a></li> <li><a href="/wiki/Brigatinib" title="Brigatinib">Brigatinib</a></li> <li><a href="/wiki/Ceritinib" title="Ceritinib">Ceritinib</a></li> <li><a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a></li> <li><a href="/wiki/Lorlatinib" title="Lorlatinib">Lorlatinib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET</a> inhibitors:</i> <a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a> (ALK, ROS1, NTRK), <a href="/wiki/Futibatinib" title="Futibatinib">Futibatinib</a> (FGFR2), <a href="/wiki/Infigratinib" title="Infigratinib">Infigratinib</a>, <a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a> (NTRK), <a href="/wiki/Pemigatinib" title="Pemigatinib">Pemigatinib</a> (FGFR), <a href="/wiki/Pralsetinib" title="Pralsetinib">Pralsetinib</a>, <a href="/wiki/Repotrectinib" title="Repotrectinib">Repotrectinib</a> (ROS1, TRK, ALK), <a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a> (VEGFR, FGFR), <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a> (VEGFR, EGFR).</li></ul> <ul><li><i><a href="/wiki/C-Met" class="mw-redirect" title="C-Met">c-MET</a> inhibitors:</i> <a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a> (VEGFR), <a href="/wiki/Capmatinib" title="Capmatinib">Capmatinib</a>, <a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a> (ALK)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Non-receptor_tyrosine_kinase" title="Non-receptor tyrosine kinase">Non-receptor</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Bcr-abl_fusion_protein" class="mw-redirect" title="Bcr-abl fusion protein">bcr-abl</a></i> <ul><li><a href="/wiki/Asciminib" title="Asciminib">Asciminib</a></li> <li><a href="/wiki/Bosutinib" title="Bosutinib">Bosutinib</a></li> <li><a href="/wiki/Dasatinib" title="Dasatinib">Dasatinib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Nilotinib" title="Nilotinib">Nilotinib</a></li> <li><a href="/wiki/Ponatinib" title="Ponatinib">Ponatinib</a></li> <li><a href="/wiki/Radotinib" title="Radotinib">Radotinib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Src_(gene)" class="mw-redirect" title="Src (gene)">Src</a></i> (<a href="/wiki/Bosutinib" title="Bosutinib">Bosutinib</a></li> <li><a href="/wiki/Dasatinib" title="Dasatinib">Dasatinib</a>)</li></ul> <ul><li><i><a href="/wiki/Janus_kinase" title="Janus kinase">Janus kinase</a> (JAK)</i> <ul><li><a href="/wiki/Baricitinib" title="Baricitinib">Baricitinib</a></li> <li><a href="/wiki/Fedratinib" title="Fedratinib">Fedratinib</a></li> <li><a href="/wiki/Filgotinib" title="Filgotinib">Filgotinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/wiki/Momelotinib" title="Momelotinib">Momelotinib</a></li> <li><a href="/wiki/Pacritinib" title="Pacritinib">Pacritinib</a></li> <li><a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Mitogen-activated_protein_kinase_kinase" title="Mitogen-activated protein kinase kinase">MAP2K</a> (MEK)</i> <ul><li><a href="/wiki/Binimetinib" title="Binimetinib">Binimetinib</a></li> <li><a href="/wiki/Cobimetinib" title="Cobimetinib">Cobimetinib</a></li> <li><a href="/wiki/Selumetinib" title="Selumetinib">Selumetinib</a></li> <li><a href="/wiki/Trametinib" title="Trametinib">Trametinib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/EML4" title="EML4">EML4</a>-<a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">ALK</a></i> <ul><li><a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/wiki/Lorlatinib" title="Lorlatinib">Lorlatinib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Bruton%27s_tyrosine_kinase" title="Bruton's tyrosine kinase">Bruton's</a> (BTK)</i> <ul><li><a href="/wiki/Acalabrutinib" title="Acalabrutinib">Acalabrutinib</a></li> <li><a href="/wiki/Ibrutinib" title="Ibrutinib">Ibrutinib</a></li> <li><a href="/wiki/Orelabrutinib" title="Orelabrutinib">Orelabrutinib</a></li> <li><a href="/wiki/Pirtobrutinib" title="Pirtobrutinib">Pirtobrutinib</a></li> <li><a href="/wiki/Zanubrutinib" title="Zanubrutinib">Zanubrutinib</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Fusion_protein" title="Fusion protein">fusion protein</a> against <a href="/wiki/Vascular_endothelial_growth_factor" title="Vascular endothelial growth factor">VEGF</a></i> (<a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a>)</li></ul> <ul><li><i><a href="/wiki/Proapoptotic" class="mw-redirect" title="Proapoptotic">proapoptotic</a> peptide against <a href="/wiki/ANXA2" class="mw-redirect" title="ANXA2">ANXA2</a> and <a href="/wiki/Prohibitin" title="Prohibitin">prohibitin</a></i> (<a href="/wiki/Adipotide" class="mw-redirect" title="Adipotide">Adipotide</a>)</li></ul> <ul><li><i><a href="/wiki/Exotoxin" title="Exotoxin">exotoxin</a> against <a href="/wiki/Interleukin_2" title="Interleukin 2">IL-2</a></i> (<a href="/wiki/Denileukin_diftitox" title="Denileukin diftitox">Denileukin diftitox</a>)</li></ul> <ul><li><i><a href="/wiki/MTOR_inhibitor" class="mw-redirect" title="MTOR inhibitor">mTOR inhibitors</a></i> <ul><li><a href="/wiki/Everolimus" title="Everolimus">Everolimus</a></li> <li><a href="/wiki/Ridaforolimus" title="Ridaforolimus">Ridaforolimus</a></li> <li><a href="/wiki/Sirolimus" title="Sirolimus">Sirolimus</a></li> <li><a href="/wiki/Temsirolimus" title="Temsirolimus">Temsirolimus</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Hedgehog_signaling_pathway" title="Hedgehog signaling pathway">hedgehog</a> inhibitors</i> <ul><li><a href="/wiki/Glasdegib" title="Glasdegib">Glasdegib</a></li> <li><a href="/wiki/Sonidegib" title="Sonidegib">Sonidegib</a></li> <li><a href="/wiki/Vismodegib" title="Vismodegib">Vismodegib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/CDK_inhibitor" title="CDK inhibitor">CDK inhibitors</a></i> <ul><li><a href="/wiki/Abemaciclib" title="Abemaciclib">Abemaciclib</a></li> <li><a href="/wiki/Dalpiciclib" title="Dalpiciclib">Dalpiciclib</a></li> <li><a href="/wiki/Palbociclib" title="Palbociclib">Palbociclib</a></li> <li><a href="/wiki/Ribociclib" title="Ribociclib">Ribociclib</a></li> <li><a href="/wiki/Trilaciclib" title="Trilaciclib">Trilaciclib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/KRAS" title="KRAS">KRAS</a> inhibitors</i> <ul><li><a href="/wiki/Adagrasib" title="Adagrasib">Adagrasib</a></li> <li><a href="/wiki/Sotorasib" title="Sotorasib">Sotorasib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Pi3K_inhibitor" class="mw-redirect" title="Pi3K inhibitor">Pi3K inhibitors</a></i> <ul><li><a href="/wiki/Alpelisib" title="Alpelisib">Alpelisib</a></li> <li><a href="/wiki/Copanlisib" title="Copanlisib">Copanlisib</a></li> <li><a href="/wiki/Duvelisib" title="Duvelisib">Duvelisib</a></li> <li><a href="/wiki/Idelalisib" title="Idelalisib">Idelalisib</a></li> <li><a href="/wiki/Inavolisib" title="Inavolisib">Inavolisib</a></li> <li><a href="/wiki/Parsaclisib" title="Parsaclisib">Parsaclisib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/MEN1" title="MEN1">Menin</a> inhibitors</i> <ul><li><a href="/wiki/Revumenib" title="Revumenib">Revumenib</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">Fibroblast growth factor receptor</a></i> (FGFR) inhibitors</li> <li><a href="/wiki/Erdafitinib" title="Erdafitinib">Erdafitinib</a></li> <li><a href="/wiki/Futibatinib" title="Futibatinib">Futibatinib</a></li> <li><a href="/wiki/Infigratinib" title="Infigratinib">Infigratinib</a></li> <li><a href="/wiki/Pemigatinib" title="Pemigatinib">Pemigatinib</a></li></ul> <ul><li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Capmatinib" title="Capmatinib">Capmatinib</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/wiki/Gilteritinib" title="Gilteritinib">Gilteritinib</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Midostaurin" title="Midostaurin">Midostaurin</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Odronextamab" title="Odronextamab">Odronextamab</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Pexidartinib" title="Pexidartinib">Pexidartinib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Regorafenib" title="Regorafenib">Regorafenib</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Tebentafusp" title="Tebentafusp">Tebentafusp</a></li> <li><a href="/wiki/Tepotinib" title="Tepotinib">Tepotinib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/wiki/Venetoclax" title="Venetoclax">Venetoclax</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Growth_factor_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Growth_factor_receptor_modulators" title="Template talk:Growth factor receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Growth_factor_receptor_modulators" title="Special:EditPage/Template:Growth factor receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Growth_factor_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">Growth factor receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Angiopoietin_receptor" title="Angiopoietin receptor">Angiopoietin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Angiopoietin_1" title="Angiopoietin 1">Angiopoietin 1</a></li> <li><a href="/wiki/Angiopoietin_4" class="mw-redirect" title="Angiopoietin 4">Angiopoietin 4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Angiopoietin_2" class="mw-redirect" title="Angiopoietin 2">Angiopoietin 2</a></li> <li><a href="/w/index.php?title=Angiopoietin_3&action=edit&redlink=1" class="new" title="Angiopoietin 3 (page does not exist)">Angiopoietin 3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Evinacumab" title="Evinacumab">Evinacumab</a> (against angiopoietin 3)</li> <li><a href="/wiki/Nesvacumab" title="Nesvacumab">Nesvacumab</a> (against angiopoietin 2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Axokine" class="mw-redirect" title="Axokine">Axokine</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></li> <li><a href="/w/index.php?title=Dapiclermin&action=edit&redlink=1" class="new" title="Dapiclermin (page does not exist)">Dapiclermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF (ErbB)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF<br /><small>(ErbB1/HER1)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Amphiregulin" title="Amphiregulin">Amphiregulin</a></li> <li><a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF (urogastrone)</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Epiregulin" title="Epiregulin">Epiregulin</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Murodermin" title="Murodermin">Murodermin</a></li> <li><a href="/wiki/Nepidermin" title="Nepidermin">Nepidermin</a></li> <li><a href="/wiki/Transforming_growth_factor_alpha" class="mw-redirect" title="Transforming growth factor alpha">Transforming growth factor alpha (TGFα)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Brigatinib" title="Brigatinib">Brigatinib</a></li> <li><a href="/wiki/Canertinib" title="Canertinib">Canertinib</a></li> <li><a href="/wiki/Dacomitinib" title="Dacomitinib">Dacomitinib</a></li> <li><a href="/wiki/Erlotinib" title="Erlotinib">Erlotinib</a></li> <li><a href="/wiki/Gefitinib" title="Gefitinib">Gefitinib</a></li> <li><a href="/wiki/Grandinin" title="Grandinin">Grandinin</a></li> <li><a href="/wiki/Icotinib" title="Icotinib">Icotinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Osimertinib" title="Osimertinib">Osimertinib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Cetuximab" title="Cetuximab">Cetuximab</a></li> <li><a href="/w/index.php?title=Depatuxizumab&action=edit&redlink=1" class="new" title="Depatuxizumab (page does not exist)">Depatuxizumab</a></li> <li><a href="/wiki/Depatuxizumab_mafodotin" title="Depatuxizumab mafodotin">Depatuxizumab mafodotin</a></li> <li><a href="/wiki/Futuximab" title="Futuximab">Futuximab</a></li> <li><a href="/wiki/Imgatuzumab" title="Imgatuzumab">Imgatuzumab</a></li> <li><a href="/wiki/Matuzumab" title="Matuzumab">Matuzumab</a></li> <li><a href="/wiki/Necitumumab" title="Necitumumab">Necitumumab</a></li> <li><a href="/wiki/Nimotuzumab" title="Nimotuzumab">Nimotuzumab</a></li> <li><a href="/wiki/Panitumumab" title="Panitumumab">Panitumumab</a></li> <li><a href="/wiki/Zalutumumab" title="Zalutumumab">Zalutumumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">ErbB2/HER2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <i>Unknown/none</i></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ertumaxomab" title="Ertumaxomab">Ertumaxomab</a></li> <li><a href="/wiki/Pertuzumab" title="Pertuzumab">Pertuzumab</a></li> <li><a href="/wiki/Trastuzumab" title="Trastuzumab">Trastuzumab</a></li> <li><a href="/wiki/Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">Trastuzumab deruxtecan</a></li> <li><a href="/w/index.php?title=Trastuzumab_duocarmazine&action=edit&redlink=1" class="new" title="Trastuzumab duocarmazine (page does not exist)">Trastuzumab duocarmazine</a></li> <li><a href="/wiki/Trastuzumab_emtansine" title="Trastuzumab emtansine">Trastuzumab emtansine</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Mubritinib" title="Mubritinib">Mubritinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a class="mw-selflink selflink">Tucatinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER3" class="mw-redirect" title="HER3">ErbB3/HER3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/CSPG5" title="CSPG5">6 (neuroglycan C)</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Duligotumab" class="mw-redirect" title="Duligotumab">Duligotumab</a></li> <li><a href="/wiki/Patritumab" title="Patritumab">Patritumab</a></li> <li><a href="/wiki/Seribantumab" title="Seribantumab">Seribantumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER4" class="mw-redirect" title="HER4">ErbB4/HER4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/NRG3" class="mw-redirect" title="NRG3">3</a>, <a href="/wiki/NRG4" class="mw-redirect" title="NRG4">4</a>, <a href="/w/index.php?title=Tomoregulin&action=edit&redlink=1" class="new" title="Tomoregulin (page does not exist)">5 (tomoregulin, TMEFF)</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF20" title="FGF20">20</a>)</li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li> <li><a href="/w/index.php?title=Velafermin&action=edit&redlink=1" class="new" title="Velafermin (page does not exist)">Velafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">FGFR2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF7" title="FGF7">7</a> (<a href="/wiki/Keratinocyte_growth_factor" title="Keratinocyte growth factor">KGF</a>), <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF17" title="FGF17">17</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF22" title="FGF22">22</a>)</li> <li><a href="/wiki/Palifermin" title="Palifermin">Palifermin</a></li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Aprutumab&action=edit&redlink=1" class="new" title="Aprutumab (page does not exist)">Aprutumab</a></li> <li><a href="/w/index.php?title=Aprutumab_ixadotin&action=edit&redlink=1" class="new" title="Aprutumab ixadotin (page does not exist)">Aprutumab ixadotin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Infigratinib" title="Infigratinib">Infigratinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF23" class="mw-redirect" title="FGF23">23</a>)</li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Burosumab" title="Burosumab">Burosumab</a> (against FGF23)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF19" title="FGF19">19</a>)</li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/FGF15/19" title="FGF15/19">FGF15/19</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Hepatocyte_growth_factor_receptor" title="Hepatocyte growth factor receptor">HGF (c-Met)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Fosgonimeton" title="Fosgonimeton">Fosgonimeton</a></li> <li><a href="/wiki/Hepatocyte_growth_factor" title="Hepatocyte growth factor">Hepatocyte growth factor</a></li></ul> <ul><li><i>Potentiators:</i> <a href="/wiki/Dihexa" title="Dihexa">Dihexa (PNB-0408)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AM7_(drug)&action=edit&redlink=1" class="new" title="AM7 (drug) (page does not exist)">AM7</a></li> <li><a href="/w/index.php?title=AMG-458&action=edit&redlink=1" class="new" title="AMG-458 (page does not exist)">AMG-458</a></li> <li><a href="/w/index.php?title=Amuvatinib&action=edit&redlink=1" class="new" title="Amuvatinib (page does not exist)">Amuvatinib</a></li> <li><a href="/w/index.php?title=BMS-777607&action=edit&redlink=1" class="new" title="BMS-777607 (page does not exist)">BMS-777607</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Capmatinib" title="Capmatinib">Capmatinib</a></li> <li><a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a></li> <li><a href="/wiki/Foretinib" title="Foretinib">Foretinib</a></li> <li><a href="/w/index.php?title=Golvatinib&action=edit&redlink=1" class="new" title="Golvatinib (page does not exist)">Golvatinib</a></li> <li><a href="/w/index.php?title=INCB28060&action=edit&redlink=1" class="new" title="INCB28060 (page does not exist)">INCB28060</a></li> <li><a href="/w/index.php?title=JNJ-38877605&action=edit&redlink=1" class="new" title="JNJ-38877605 (page does not exist)">JNJ-38877605</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/w/index.php?title=MK-2461&action=edit&redlink=1" class="new" title="MK-2461 (page does not exist)">MK-2461</a></li> <li><a href="/w/index.php?title=PF-04217903&action=edit&redlink=1" class="new" title="PF-04217903 (page does not exist)">PF-04217903</a></li> <li><a href="/w/index.php?title=PF-2341066&action=edit&redlink=1" class="new" title="PF-2341066 (page does not exist)">PF-2341066</a></li> <li><a href="/w/index.php?title=PHA-665752&action=edit&redlink=1" class="new" title="PHA-665752 (page does not exist)">PHA-665752</a></li> <li><a href="/w/index.php?title=SU-11274&action=edit&redlink=1" class="new" title="SU-11274 (page does not exist)">SU-11274</a></li> <li><a href="/wiki/Tivantinib" title="Tivantinib">Tivantinib</a></li> <li><a href="/wiki/Volitinib" class="mw-redirect" title="Volitinib">Volitinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Emibetuzumab" title="Emibetuzumab">Emibetuzumab</a></li> <li><a href="/wiki/Ficlatuzumab" title="Ficlatuzumab">Ficlatuzumab</a></li> <li><a href="/wiki/Flanvotumab" title="Flanvotumab">Flanvotumab</a></li> <li><a href="/wiki/Onartuzumab" title="Onartuzumab">Onartuzumab</a></li> <li><a href="/wiki/Rilotumumab" title="Rilotumumab">Rilotumumab</a></li> <li><a href="/w/index.php?title=Telisotuzumab&action=edit&redlink=1" class="new" title="Telisotuzumab (page does not exist)">Telisotuzumab</a></li> <li><a href="/wiki/Telisotuzumab_vedotin" title="Telisotuzumab vedotin">Telisotuzumab vedotin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Somatomedin_receptor" title="Somatomedin receptor">IGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">IGF-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Des(1-3)IGF-1" title="Des(1-3)IGF-1">des(1-3)IGF-1</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1" title="Insulin-like growth factor 1">Insulin-like growth factor-1 (somatomedin C)</a></li> <li><a href="/wiki/IGF-1_LR3" title="IGF-1 LR3">IGF-1 LR3</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li> <li><a href="/wiki/Insulin" title="Insulin">Insulin</a></li> <li><a href="/wiki/Mecasermin" title="Mecasermin">Mecasermin</a></li> <li><a href="/wiki/Mecasermin_rinfabate" title="Mecasermin rinfabate">Mecasermin rinfabate</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=BMS-754807&action=edit&redlink=1" class="new" title="BMS-754807 (page does not exist)">BMS-754807</a></li> <li><a href="/wiki/Linsitinib" title="Linsitinib">Linsitinib</a></li> <li><a href="/w/index.php?title=NVP-ADW742&action=edit&redlink=1" class="new" title="NVP-ADW742 (page does not exist)">NVP-ADW742</a></li> <li><a href="/w/index.php?title=NVP-AEW541&action=edit&redlink=1" class="new" title="NVP-AEW541 (page does not exist)">NVP-AEW541</a></li> <li><a href="/w/index.php?title=OSl-906&action=edit&redlink=1" class="new" title="OSl-906 (page does not exist)">OSl-906</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=AVE-1642&action=edit&redlink=1" class="new" title="AVE-1642 (page does not exist)">AVE-1642</a></li> <li><a href="/wiki/Cixutumumab" title="Cixutumumab">Cixutumumab</a></li> <li><a href="/wiki/Dalotuzumab" title="Dalotuzumab">Dalotuzumab</a></li> <li><a href="/wiki/Figitumumab" title="Figitumumab">Figitumumab</a></li> <li><a href="/wiki/Ganitumab" title="Ganitumab">Ganitumab</a></li> <li><a href="/wiki/Robatumumab" title="Robatumumab">Robatumumab</a></li> <li><a href="/w/index.php?title=R1507&action=edit&redlink=1" class="new" title="R1507 (page does not exist)">R1507</a></li> <li><a href="/wiki/Teprotumumab" title="Teprotumumab">Teprotumumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">IGF-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dusigitumab" title="Dusigitumab">Dusigitumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Binding proteins:</i> <a href="/wiki/Insulin-like_growth_factor-binding_protein" title="Insulin-like growth factor-binding protein">IGFBP</a> (<a href="/wiki/IGFBP1" title="IGFBP1">1</a>, <a href="/wiki/IGFBP2" title="IGFBP2">2</a>, <a href="/wiki/IGFBP3" title="IGFBP3">3</a>, <a href="/wiki/IGFBP4" title="IGFBP4">4</a>, <a href="/wiki/IGFBP5" title="IGFBP5">5</a>, <a href="/wiki/IGFBP6" title="IGFBP6">6</a>, <a href="/wiki/IGFBP7" title="IGFBP7">7</a>)</li></ul> <ul><li><i>Cleavage products/derivatives with unknown target:</i> <a href="/w/index.php?title=Glypromate&action=edit&redlink=1" class="new" title="Glypromate (page does not exist)">Glypromate (GPE, (1-3)IGF-1)</a></li> <li><a href="/wiki/Trofinetide" title="Trofinetide">Trofinetide</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">LNGF (p75<sup>NTR</sup>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/w/index.php?title=EVT-901&action=edit&redlink=1" class="new" title="EVT-901 (page does not exist)">EVT-901 (SAR-127963)</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Antibodies:</i> <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=LEVI-04&action=edit&redlink=1" class="new" title="LEVI-04 (page does not exist)">LEVI-04 (p75<sup>NTR</sup>-Fc)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Becaplermin" title="Becaplermin">Becaplermin</a></li> <li><a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">Platelet-derived growth factor</a> (<a href="/wiki/PDGFA" title="PDGFA">A</a>, <a href="/wiki/PDGFB" title="PDGFB">B</a>, <a href="/wiki/PDGFC" title="PDGFC">C</a>, <a href="/wiki/PDGFD" title="PDGFD">D</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Avapritinib" title="Avapritinib">Avapritinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Crenolanib" title="Crenolanib">Crenolanib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Radotinib" title="Radotinib">Radotinib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Olaratumab" title="Olaratumab">Olaratumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Tovetumab" title="Tovetumab">Tovetumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET (GFL)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B11" class="mw-redirect" title="GFRα1">GFRα1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Glial_cell_line-derived_neurotrophic_factor" title="Glial cell line-derived neurotrophic factor">Glial cell line-derived neurotrophic factor (GDNF)</a></li> <li><a href="/w/index.php?title=Liatermin&action=edit&redlink=1" class="new" title="Liatermin (page does not exist)">Liatermin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B12" class="mw-redirect" title="GFRα2">GFRα2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neurturin" title="Neurturin">Neurturin (NRTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B13" class="mw-redirect" title="GFRα3">GFRα3</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Artemin" title="Artemin">Artemin (ARTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B14" class="mw-redirect" title="GFRα4">GFRα4</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Persephin" title="Persephin">Persephin (PSPN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CD117" class="mw-redirect" title="CD117">SCF (c-Kit)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Ancestim" title="Ancestim">Ancestim</a></li> <li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">Stem cell factor</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Dasatinib" title="Dasatinib">Dasatinib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Nilotinib" title="Nilotinib">Nilotinib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Transforming_growth_factor_beta_receptor" class="mw-redirect" title="Transforming growth factor beta receptor">TGFβ</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Trk_receptor" title="Trk receptor">Trk</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">TrkA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/w/index.php?title=Gambogic_amide&action=edit&redlink=1" class="new" title="Gambogic amide (page does not exist)">Gambogic amide</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Tavilermide" title="Tavilermide">Tavilermide</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/wiki/FX007" class="mw-redirect" title="FX007">FX007</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Negative allosteric modulators:</i> <a href="/w/index.php?title=VM-902A&action=edit&redlink=1" class="new" title="VM-902A (page does not exist)">VM-902A</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=Milciclib&action=edit&redlink=1" class="new" title="Milciclib (page does not exist)">Milciclib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/w/index.php?title=SNA-120&action=edit&redlink=1" class="new" title="SNA-120 (page does not exist)">SNA-120 (pegylated K252a)</a>)</li></ul> <ul><li><i>Antibodies:</i> <i>Against TrkA:</i> <a href="/w/index.php?title=GBR-900&action=edit&redlink=1" class="new" title="GBR-900 (page does not exist)">GBR-900</a>; <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=ReN-1820&action=edit&redlink=1" class="new" title="ReN-1820 (page does not exist)">ReN-1820 (TrkAd5)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkB_receptor" class="mw-redirect" title="TrkB receptor">TrkB</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=3,7-Dihydroxyflavone&action=edit&redlink=1" class="new" title="3,7-Dihydroxyflavone (page does not exist)">3,7-DHF</a></li> <li><a href="/w/index.php?title=3,7,8,2%27-Tetrahydroxyflavone&action=edit&redlink=1" class="new" title="3,7,8,2'-Tetrahydroxyflavone (page does not exist)">3,7,8,2'-THF</a></li> <li><a href="/wiki/4%27-Dimethylamino-7,8-dihydroxyflavone" class="mw-redirect" title="4'-Dimethylamino-7,8-dihydroxyflavone">4'-DMA-7,8-DHF</a></li> <li><a href="/w/index.php?title=7,3%E2%80%B2-Dihydroxyflavone&action=edit&redlink=1" class="new" title="7,3′-Dihydroxyflavone (page does not exist)">7,3'-DHF</a></li> <li><a href="/wiki/7,8-Dihydroxyflavone" class="mw-redirect" title="7,8-Dihydroxyflavone">7,8-DHF</a></li> <li><a href="/w/index.php?title=7,8,2%27-Trihydroxyflavone&action=edit&redlink=1" class="new" title="7,8,2'-Trihydroxyflavone (page does not exist)">7,8,2'-THF</a></li> <li><a href="/wiki/7,8,3%27-Trihydroxyflavone" title="7,8,3'-Trihydroxyflavone">7,8,3'-THF</a></li> <li><a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Deoxygedunin" title="Deoxygedunin">Deoxygedunin</a></li> <li><a href="/wiki/Deprenyl" title="Deprenyl">Deprenyl</a></li> <li><a href="/wiki/Diosmetin" title="Diosmetin">Diosmetin</a></li> <li><a href="/w/index.php?title=DMAQ-B1&action=edit&redlink=1" class="new" title="DMAQ-B1 (page does not exist)">DMAQ-B1</a></li> <li><a href="/wiki/HIOC" title="HIOC">HIOC</a></li> <li><a href="/wiki/LM22A-4" title="LM22A-4">LM22A-4</a></li> <li><a href="/wiki/N-Acetylserotonin" title="N-Acetylserotonin">N-Acetylserotonin</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li> <li><a href="/wiki/Norwogonin" title="Norwogonin">Norwogonin (5,7,8-THF)</a></li> <li><a href="/wiki/R7_(drug)" title="R7 (drug)">R7</a></li> <li><a href="/wiki/R13_(drug)" title="R13 (drug)">R13</a></li> <li><a href="/w/index.php?title=TDP6&action=edit&redlink=1" class="new" title="TDP6 (page does not exist)">TDP6</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/ANA-12" title="ANA-12">ANA-12</a></li> <li><a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li> <li><a href="/wiki/Gossypetin" title="Gossypetin">Gossypetin (3,5,7,8,3',4'-HHF)</a></li></ul> <ul><li><i>Ligands:</i> <a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkC_receptor" class="mw-redirect" title="TrkC receptor">TrkC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Vascular_endothelial_growth_factor_receptor" class="mw-redirect" title="Vascular endothelial growth factor receptor">VEGF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Placental_growth_factor" title="Placental growth factor">Placental growth factor (PGF)</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/w/index.php?title=Telbermin&action=edit&redlink=1" class="new" title="Telbermin (page does not exist)">Telbermin</a></li> <li><a href="/wiki/Vascular_endothelial_growth_factor" title="Vascular endothelial growth factor">VEGF</a> (<a href="/wiki/Vascular_endothelial_growth_factor_A" title="Vascular endothelial growth factor A">A</a>, <a href="/wiki/Vascular_endothelial_growth_factor_B" title="Vascular endothelial growth factor B">B</a>, <a href="/wiki/Vascular_endothelial_growth_factor_C" title="Vascular endothelial growth factor C">C</a>, <a href="/wiki/Vascular_endothelial_growth_factor_D" class="mw-redirect" title="Vascular endothelial growth factor D">D (FIGF)</a>)</li></ul> <ul><li><i>Allosteric modulators:</i> <a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Cediranib" title="Cediranib">Cediranib</a></li> <li><a href="/wiki/Fruquintinib" title="Fruquintinib">Fruquintinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Pegaptanib" title="Pegaptanib">Pegaptanib</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/wiki/Regorafenib" title="Regorafenib">Regorafenib</a></li> <li><a href="/wiki/Semaxanib" title="Semaxanib">Semaxanib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li> <li><a href="/wiki/Tivozanib" title="Tivozanib">Tivozanib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Alacizumab_pegol" title="Alacizumab pegol">Alacizumab pegol</a></li> <li><a href="/wiki/Bevacizumab" title="Bevacizumab">Bevacizumab</a></li> <li><a href="/wiki/Icrucumab" title="Icrucumab">Icrucumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Ranibizumab" title="Ranibizumab">Ranibizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Additional growth factors:</i> <a href="/wiki/Adrenomedullin" title="Adrenomedullin">Adrenomedullin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Connective_tissue_growth_factor" class="mw-redirect" title="Connective tissue growth factor">Connective tissue growth factor (CTGF)</a></li> <li><a href="/wiki/Ephrin" title="Ephrin">Ephrins</a> (<a href="/wiki/EFNA1" class="mw-redirect" title="EFNA1">A1</a>, <a href="/wiki/EFNA2" class="mw-redirect" title="EFNA2">A2</a>, <a href="/wiki/EFNA3" class="mw-redirect" title="EFNA3">A3</a>, <a href="/wiki/EFNA4" class="mw-redirect" title="EFNA4">A4</a>, <a href="/wiki/EFNA5" class="mw-redirect" title="EFNA5">A5</a>, <a href="/wiki/EFNB1" class="mw-redirect" title="EFNB1">B1</a>, <a href="/wiki/EFNB2" class="mw-redirect" title="EFNB2">B2</a>, <a href="/wiki/EFNB3" class="mw-redirect" title="EFNB3">B3</a>)</li> <li><a href="/wiki/Erythropoietin" title="Erythropoietin">Erythropoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Glucose-6-phosphate_isomerase" title="Glucose-6-phosphate isomerase">Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)</a></li> <li><a href="/wiki/Glia_maturation_factor" title="Glia maturation factor">Glia maturation factor (GMF)</a></li> <li><a href="/wiki/Hepatoma-derived_growth_factor" title="Hepatoma-derived growth factor">Hepatoma-derived growth factor (HDGF)</a></li> <li><a href="/wiki/Interleukin" title="Interleukin">Interleukins</a>/<a href="/wiki/T-cell_growth_factor" title="T-cell growth factor">T-cell growth factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">Leukemia inhibitory factor (LIF)</a></li> <li><a href="/wiki/Macrophage-stimulating_protein" class="mw-redirect" title="Macrophage-stimulating protein">Macrophage-stimulating protein (MSP; HLP, HGFLP)</a></li> <li><a href="/wiki/Midkine" title="Midkine">Midkine (NEGF2)</a></li> <li><a href="/wiki/Migration-stimulating_factor" class="mw-redirect" title="Migration-stimulating factor">Migration-stimulating factor (MSF; PRG4)</a></li> <li><a href="/wiki/Oncomodulin" title="Oncomodulin">Oncomodulin</a></li> <li><a href="/wiki/Pituitary_adenylate_cyclase-activating_peptide" title="Pituitary adenylate cyclase-activating peptide">Pituitary adenylate cyclase-activating peptide (PACAP)</a></li> <li><a href="/wiki/Pleiotrophin" title="Pleiotrophin">Pleiotrophin</a></li> <li><a href="/wiki/Renalase" title="Renalase">Renalase</a></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt signaling proteins</a></li></ul> <ul><li><i>Additional growth factor receptor modulators:</i> <a href="/wiki/Cerebrolysin" title="Cerebrolysin">Cerebrolysin</a> (neurotrophin mixture)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;padding:0.15em 0;column-gap:1em;align-items:baseline;margin:0;list-style:none}.mw-parser-output .portal-bar-content-related{margin:0;list-style:none}.mw-parser-output .portal-bar-item{display:inline-block;margin:0.15em 0.2em;min-height:24px;line-height:24px}@media screen and (max-width:768px){.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;flex-flow:column wrap;align-items:baseline}.mw-parser-output .portal-bar-header{text-align:center;flex:0;padding-left:0.5em;margin:0 auto}.mw-parser-output .portal-bar-related{font-size:100%;align-items:flex-start}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;align-items:center;flex:0;column-gap:1em;border-top:1px solid #a2a9b1;margin:0 auto;list-style:none}.mw-parser-output .portal-bar-content-related{border-top:none;margin:0;list-style:none}}.mw-parser-output .navbox+link+.portal-bar,.mw-parser-output .navbox+style+.portal-bar,.mw-parser-output .navbox+link+.portal-bar-bordered,.mw-parser-output .navbox+style+.portal-bar-bordered,.mw-parser-output .sister-bar+link+.portal-bar,.mw-parser-output .sister-bar+style+.portal-bar,.mw-parser-output .portal-bar+.navbox-styles+.navbox,.mw-parser-output .portal-bar+.navbox-styles+.sister-bar{margin-top:-1px}</style><div class="portal-bar noprint metadata noviewer portal-bar-bordered" role="navigation" aria-label="Portals"><span class="portal-bar-header"><a href="/wiki/Wikipedia:Contents/Portals" title="Wikipedia:Contents/Portals">Portal</a>:</span><ul class="portal-bar-content"><li class="portal-bar-item"><span class="nowrap"><span typeof="mw:File"><span><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/8px-WHO_Rod.svg.png" decoding="async" width="8" height="19" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/12px-WHO_Rod.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/16px-WHO_Rod.svg.png 2x" data-file-width="107" data-file-height="250" /></span></span> </span><a href="/wiki/Portal:Medicine" title="Portal:Medicine">Medicine</a></li></ul></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Tucatinib&oldid=1234794657">https://en.wikipedia.org/w/index.php?title=Tucatinib&oldid=1234794657</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Antineoplastic_drugs" title="Category:Antineoplastic drugs">Antineoplastic drugs</a></li><li><a href="/wiki/Category:Cancer_treatments" title="Category:Cancer treatments">Cancer treatments</a></li><li><a href="/wiki/Category:CYP3A4_inhibitors" title="Category:CYP3A4 inhibitors">CYP3A4 inhibitors</a></li><li><a href="/wiki/Category:Orphan_drugs" title="Category:Orphan drugs">Orphan drugs</a></li><li><a href="/wiki/Category:Quinazolines" title="Category:Quinazolines">Quinazolines</a></li><li><a href="/wiki/Category:Receptor_tyrosine_kinase_inhibitors" title="Category:Receptor tyrosine kinase inhibitors">Receptor tyrosine kinase inhibitors</a></li><li><a href="/wiki/Category:Triazolopyridines" title="Category:Triazolopyridines">Triazolopyridines</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:All_articles_with_dead_external_links" title="Category:All articles with dead external links">All articles with dead external links</a></li><li><a href="/wiki/Category:Articles_with_dead_external_links_from_March_2023" title="Category:Articles with dead external links from March 2023">Articles with dead external links from March 2023</a></li><li><a href="/wiki/Category:Articles_with_permanently_dead_external_links" title="Category:Articles with permanently dead external links">Articles with permanently dead external links</a></li><li><a href="/wiki/Category:Source_attribution" title="Category:Source attribution">Source attribution</a></li><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_matches_Wikidata" title="Category:Short description matches Wikidata">Short description matches Wikidata</a></li><li><a href="/wiki/Category:Use_dmy_dates_from_January_2023" title="Category:Use dmy dates from January 2023">Use dmy dates from January 2023</a></li><li><a href="/wiki/Category:Drugs_with_non-standard_legal_status" title="Category:Drugs with non-standard legal status">Drugs with non-standard legal status</a></li><li><a href="/wiki/Category:Articles_containing_unverified_chemical_infoboxes" title="Category:Articles containing unverified chemical infoboxes">Articles containing unverified chemical infoboxes</a></li><li><a href="/wiki/Category:Articles_containing_potentially_dated_statements_from_April_2020" title="Category:Articles containing potentially dated statements from April 2020">Articles containing potentially dated statements from April 2020</a></li><li><a href="/wiki/Category:All_articles_containing_potentially_dated_statements" title="Category:All articles containing potentially dated statements">All articles containing potentially dated statements</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 16 July 2024, at 05:17<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. By using this site, you agree to the <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use" class="extiw" title="foundation:Special:MyLanguage/Policy:Terms of Use">Terms of Use</a> and <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy" class="extiw" title="foundation:Special:MyLanguage/Policy:Privacy policy">Privacy Policy</a>. Wikipedia® is a registered trademark of the <a rel="nofollow" class="external text" href="https://wikimediafoundation.org/">Wikimedia Foundation, Inc.</a>, a non-profit organization.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Privacy policy</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:About">About Wikipedia</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:General_disclaimer">Disclaimers</a></li> <li id="footer-places-contact"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us">Contact Wikipedia</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Code of Conduct</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Developers</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/en.wikipedia.org">Statistics</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Cookie statement</a></li> <li id="footer-places-mobileview"><a href="//en.m.wikipedia.org/w/index.php?title=Tucatinib&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobile view</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-f69cdc8f6-ktjkx","wgBackendResponseTime":138,"wgPageParseReport":{"limitreport":{"cputime":"1.011","walltime":"1.300","ppvisitednodes":{"value":6820,"limit":1000000},"postexpandincludesize":{"value":238812,"limit":2097152},"templateargumentsize":{"value":7600,"limit":2097152},"expansiondepth":{"value":23,"limit":100},"expensivefunctioncount":{"value":6,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":121223,"limit":5000000},"entityaccesscount":{"value":1,"limit":400},"timingprofile":["100.00% 986.493 1 -total"," 38.71% 381.906 1 Template:Infobox_drug"," 31.39% 309.654 1 Template:Infobox"," 23.98% 236.526 1 Template:Reflist"," 17.95% 177.117 9 Template:Navbox"," 15.73% 155.214 19 Template:Cite_web"," 13.18% 129.988 1 Template:Extracellular_chemotherapeutic_agents"," 9.18% 90.560 1 Template:Short_description"," 6.94% 68.414 17 Template:Unbulleted_list"," 5.36% 52.887 1 Template:Chem_molar_mass"]},"scribunto":{"limitreport-timeusage":{"value":"0.516","limit":"10.000"},"limitreport-memusage":{"value":9526589,"limit":52428800}},"cachereport":{"origin":"mw-api-int.codfw.main-849f99967d-kdrfg","timestamp":"20241123072338","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"Tucatinib","url":"https:\/\/en.wikipedia.org\/wiki\/Tucatinib","sameAs":"http:\/\/www.wikidata.org\/entity\/Q25100690","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q25100690","author":{"@type":"Organization","name":"Contributors to Wikimedia projects"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2017-01-31T20:02:59Z","dateModified":"2024-07-16T05:17:03Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/a\/a7\/Tucatinib.svg","headline":"chemical compound"}</script> </body> </html>