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Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A" /> <meta name="citation_publication_date" content="2009/01/01" /> <meta name="citation_journal_title" content="Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society" /> <meta name="citation_author" content="Essam Zaki" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/2530854/Are_pediatric_and_adult_onset_cyclic_vomiting_syndrome_CVS_biologically_different_conditions_Relationship_of_adult_onset_CVS_with_the_migraine_and_pediatric_CVS_associated_common_mtDNA_polymorphisms_16519T_and_3010A" /> <meta name="twitter:title" content="Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A" /> <meta name="twitter:description" content="Pediatric cyclic vomiting syndrome (CVS) is associated with a high prevalence of co-morbid migraine and other functional disorders, and with two adult migraine-associated mitochondrial DNA (mtDNA) polymorphisms: 16519T and 3010A. These potential" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/2530854/Are_pediatric_and_adult_onset_cyclic_vomiting_syndrome_CVS_biologically_different_conditions_Relationship_of_adult_onset_CVS_with_the_migraine_and_pediatric_CVS_associated_common_mtDNA_polymorphisms_16519T_and_3010A" /> <meta property="og:title" content="Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Pediatric cyclic vomiting syndrome (CVS) is associated with a high prevalence of co-morbid migraine and other functional disorders, and with two adult migraine-associated mitochondrial DNA (mtDNA) polymorphisms: 16519T and 3010A. These potential" /> <meta property="article:author" content="https://usc.academia.edu/EssamZaki" /> <meta name="description" content="Pediatric cyclic vomiting syndrome (CVS) is associated with a high prevalence of co-morbid migraine and other functional disorders, and with two adult migraine-associated mitochondrial DNA (mtDNA) polymorphisms: 16519T and 3010A. These potential" /> <title>(PDF) Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F2530854%2FAre_pediatric_and_adult_onset_cyclic_vomiting_syndrome_CVS_biologically_different_conditions_Relationship_of_adult_onset_CVS_with_the_migraine_and_pediatric_CVS_associated_common_mtDNA_polymorphisms_16519T_and_3010A%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":30546204,"identifier":"Attachment_30546204","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":2530854,"created_at":"2013-02-07T04:33:11.400-08:00","from_world_paper_id":116853167,"updated_at":"2024-11-13T14:34:47.798-08:00","_data":{"publisher":"ncbi.nlm.nih.gov","grobid_abstract":"Pediatric cyclic vomiting syndrome (CVS) is associated with a high prevalence of co-morbid migraine and other functional disorders, and with two adult migraine-associated mitochondrial DNA (mtDNA) polymorphisms: 16519T and 3010A. These potential associations have not been studied in adult CVS. The objective of this study is to determine the prevalence of 16519T and 3010A mtDNA polymorphisms and other functional disorders in adult CVS patients. Adults with CVS recruited from the University of Kansas meeting Rome III criteria and a population control group completed a self-reported survey that included questions relating to the diagnostic criteria for several functional disorders. DNA was isolated from blood or saliva and genotyping was performed by standard methodologies. Adult CVS subjects, compared to controls, had significantly more symptoms consistent with several other functional disorders. 16519T was present in 22/31 cases (71%) of child-onset (\u003c12 years) and 9/31 (29%) cases of adultonset (18+ years) CVS (P = 0.01), vs 27% of controls. Among subjects with 16519T, 3010A was present in 30% of child-onset vs 0% of adult-onset CVS (P = 0.05) and 2% of controls. The conclusions drawn were: (i) unlike pediatric CVS, adult CVS is not associated with the 16519T and 3010A mtDNA polymorphisms, suggesting a degree of genetic distinction and (ii) similar to the pediatric setting, adult CVS is associated with a substantial burden of co-morbid functional disorders.","publication_date":"2009,,","publication_name":"Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society","grobid_abstract_attachment_id":"30546204"},"document_type":"paper","pre_hit_view_count_baseline":0,"quality":"high","language":"en","title":"Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [3070540]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":30546204,"attachmentType":"pdf"}"><img alt="First page of “Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/30546204/mini_magick20190426-14051-pva0ju.png?1556332094" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki"><img alt="Profile image of Essam Zaki" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Essam Zaki</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">5 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 2530854; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=2530854"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Pediatric cyclic vomiting syndrome (CVS) is associated with a high prevalence of co-morbid migraine and other functional disorders, and with two adult migraine-associated mitochondrial DNA (mtDNA) polymorphisms: 16519T and 3010A. These potential associations have not been studied in adult CVS. The objective of this study is to determine the prevalence of 16519T and 3010A mtDNA polymorphisms and other functional disorders in adult CVS patients. Adults with CVS recruited from the University of Kansas meeting Rome III criteria and a population control group completed a self-reported survey that included questions relating to the diagnostic criteria for several functional disorders. DNA was isolated from blood or saliva and genotyping was performed by standard methodologies. Adult CVS subjects, compared to controls, had significantly more symptoms consistent with several other functional disorders. 16519T was present in 22/31 cases (71%) of child-onset (<12 years) and 9/31 (29%) cases of adultonset (18+ years) CVS (P = 0.01), vs 27% of controls. Among subjects with 16519T, 3010A was present in 30% of child-onset vs 0% of adult-onset CVS (P = 0.05) and 2% of controls. The conclusions drawn were: (i) unlike pediatric CVS, adult CVS is not associated with the 16519T and 3010A mtDNA polymorphisms, suggesting a degree of genetic distinction and (ii) similar to the pediatric setting, adult CVS is associated with a substantial burden of co-morbid functional disorders.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":30546204,"attachmentType":"pdf","workUrl":"https://www.academia.edu/2530854/Are_pediatric_and_adult_onset_cyclic_vomiting_syndrome_CVS_biologically_different_conditions_Relationship_of_adult_onset_CVS_with_the_migraine_and_pediatric_CVS_associated_common_mtDNA_polymorphisms_16519T_and_3010A"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":30546204,"attachmentType":"pdf","workUrl":"https://www.academia.edu/2530854/Are_pediatric_and_adult_onset_cyclic_vomiting_syndrome_CVS_biologically_different_conditions_Relationship_of_adult_onset_CVS_with_the_migraine_and_pediatric_CVS_associated_common_mtDNA_polymorphisms_16519T_and_3010A"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas" data-impression-entity-id="2530854" data-impression-entity-type="2" data-impression-source="signup-banner"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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In the past the disorder was considered to be fairly uncommon, of unknown etiology. Most cases of CVS have been described as sporadic, but family history may be an important factor. Here we present an 18-year-old male patient with symptoms of recurrent spells of intense vomiting. The objective of this study was to determine the presence of mtDNA polymorphisms in a patient with a pediatric-onset CVS as an indication of genetic association that confers an increased risk towards disease pathogenesis.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"IDENTIFICATION OF mtDNA 7028C AND 16519T POLYMORPHISMS IN A PEDIATRIC-ONSET CYCLIC VOMITING SYNDROME (CVS) PATIENT","attachmentId":97230722,"attachmentType":"pdf","work_url":"https://www.academia.edu/94898098/IDENTIFICATION_OF_mtDNA_7028C_AND_16519T_POLYMORPHISMS_IN_A_PEDIATRIC_ONSET_CYCLIC_VOMITING_SYNDROME_CVS_PATIENT","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/94898098/IDENTIFICATION_OF_mtDNA_7028C_AND_16519T_POLYMORPHISMS_IN_A_PEDIATRIC_ONSET_CYCLIC_VOMITING_SYNDROME_CVS_PATIENT"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="8985463" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/8985463/Quantitative_pedigree_analysis_and_mitochondrial_DNA_sequence_variants_in_adults_with_cyclic_vomiting_syndrome">Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Abstract Background Children with cyclic vomiting syndrome (CVS) have a high degree of maternal inheritance of functional gastrointestinal and neurological disorders. CVS in children is also associated with an increased prevalence of mitochondrial DNA single-nucleotide polymorphisms (mtDNA SNPs) 16519 T and 3010A. Preliminary data suggests that age of onset of symptoms (pediatric vs. adult) may be a determinant of the presence of such mtDNA SNP’s. We sought to examine the degree of maternal inheritance pattern of functional disorders and the prevalence of mtDNA SNP’s16519T and 3010A in adults with CVS and correlate this with age of onset of disease. Methods A Quantitative Pedigree Analysis (QPA) was performed in 195 of a total of 216 patients and all were genotyped using Restriction Fragment Length Polymorphism (RFLP) or sequencing. Results Adults with CVS had a higher degree of probable maternal inheritance (PMI) of functional disorders than controls (12% vs. 1%, p < 0.001). However, the prevalence of mitochondrial SNP’s 16519 T, 3010A and the AT genotype were similar in Haplogroup H CVS patients compared to historical controls. There was no correlation between age of onset of disease and prevalence of these mtDNA SNP’s. Conclusions A subset of adults with CVS has a significantly higher degree of maternal inheritance pattern of functional disorders than controls. There was no association with mtDNA SNP’s 16519 T and 3010A as seen in children and future studies sequencing the entire mitochondrial and nuclear genome to identify potential causes for this maternal inheritance pattern in adults are warranted.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome","attachmentId":35299116,"attachmentType":"pdf","work_url":"https://www.academia.edu/8985463/Quantitative_pedigree_analysis_and_mitochondrial_DNA_sequence_variants_in_adults_with_cyclic_vomiting_syndrome","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/8985463/Quantitative_pedigree_analysis_and_mitochondrial_DNA_sequence_variants_in_adults_with_cyclic_vomiting_syndrome"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="33519466" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33519466/Mitochondrial_DNA_control_region_sequence_variation_in_migraine_headache_and_cyclic_vomiting_syndrome">Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="53651164" href="https://independent.academia.edu/LuisCalebMercadoAlvarez">Luis Caleb Mercado Alvarez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Medical Genetics, 2004</p><p class="ds-related-work--abstract ds2-5-body-sm">Migraine headache is a very common condition affecting about 10% of the population that results in substantial morbidity and economic loss. The two most common variants are migraine with (MA) and without (MO) aura. Often considered to be a migraine-like variant, cyclic vomiting syndrome (CVS) is a predominately childhood condition characterized by severe, discrete episodes of nausea, vomiting, and lethargy. Disease-associated mitochondrial DNA (mtDNA) sequence variants are suggested in common migraine and CVS based upon a strong bias towards the maternal inheritance of disease, and several other factors. Temporal temperature gradient gel electrophoresis (TTGE) followed by cyclosequencing and RFLP was used to screen almost 90% of the mtDNA, including the control region (CR), for heteroplasmy in 62 children with CVS and neuromuscular disease (CVSþ) and in 95 control subjects. One or two rare mtDNA-CR heteroplasmic sequence variants were found in six CVSþ and in zero control subjects (P ¼ 0.003). These variants comprised 6 point and 2 length variants in hypervariable regions 1 and 2 (HV1 and HV2, both part of the mtDNA-CR), one half of which were clustered in the nt 16040-16188 segment of HV1 that includes the termination associated sequence (TAS), a functional location important in the regulation of mtDNA replication. Based upon our findings, sequencing and statistical analysis looking for homoplasmic nucleotide changes was performed in HV1 among 30 CVSþ, 30 randomlyascertained CVS (rCVS), 18 MA, 32 MO, and 35 control haplogroup H cases. Within the nt 16040-16188 segment, homoplasmic sequence variants were three-fold more common relative to control subjects in both CVS groups (P ¼ 0.01 combined data) and in MO (P ¼ 0.02), but not in MA (P ¼ 0.5 vs. control subjects and 0.02 vs. MO). No group differences were noted in the remainder of HV1. We conclude that sequence variation in this small ''peri-TAS'' segment is associated with CVS and MO, but not MA. These variants likely constitute risk factors for disease development. Our findings are consistent with previous data demonstrating progression of CVS into MO in many cases, and the co-segregation in a maternal inheritance pattern of CVS and MO within families. A mitochondrial component in the pathogenesis of migraine and CVS has therapeutic implications, especially concerning the avoidance of fasting.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome","attachmentId":53554929,"attachmentType":"pdf","work_url":"https://www.academia.edu/33519466/Mitochondrial_DNA_control_region_sequence_variation_in_migraine_headache_and_cyclic_vomiting_syndrome","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/33519466/Mitochondrial_DNA_control_region_sequence_variation_in_migraine_headache_and_cyclic_vomiting_syndrome"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="13105860" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13105860/Assessing_the_Relative_Incidence_of_Mitochondrial_DNA_A3243G_in_Migraine_Without_Aura_With_Maternal_Inheritance">Assessing the Relative Incidence of Mitochondrial DNA A3243G in Migraine Without Aura With Maternal Inheritance</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32356591" href="https://independent.academia.edu/GiancarloDiGennaro">Giancarlo Di Gennaro</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Headache: The Journal of Head and Face Pain, 2000</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective.-To determine whether patients with migraine without aura with maternal "inheritance" are affected by a monosymptomatic form of the MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes) or carry the most common mitochondrial DNA (mtDNA) mutation associated with MELAS, namely the A3243G transition in the transfer RNA (tRNA) Leu(UUR) gene.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Assessing the Relative Incidence of Mitochondrial DNA A3243G in Migraine Without Aura With Maternal Inheritance","attachmentId":45680079,"attachmentType":"pdf","work_url":"https://www.academia.edu/13105860/Assessing_the_Relative_Incidence_of_Mitochondrial_DNA_A3243G_in_Migraine_Without_Aura_With_Maternal_Inheritance","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13105860/Assessing_the_Relative_Incidence_of_Mitochondrial_DNA_A3243G_in_Migraine_Without_Aura_With_Maternal_Inheritance"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="115216645" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/115216645/Mitochondrial_DNA_control_region_sequence_variation_in_the_NE_Portuguese_Jewish_community">Mitochondrial DNA-control region sequence variation in the NE Portuguese Jewish community</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29600861" href="https://independent.academia.edu/InesNogueiro">Ines Nogueiro</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Forensic Science International: Genetics Supplement Series, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Migraine headache is a very common condition affecting about 10% of the population that results in substantial morbidity and economic loss. The two most common variants are migraine with (MA) and without (MO) aura. Often considered to be a migraine-like variant, cyclic vomiting syndrome (CVS) is a predominately childhood condition characterized by severe, discrete episodes of nausea, vomiting, and lethargy. Disease-associated mitochondrial DNA (mtDNA) sequence variants are suggested in common migraine and CVS based upon a strong bias towards the maternal inheritance of disease, and several other factors. Temporal temperature gradient gel electrophoresis (TTGE) followed by cyclosequencing and RFLP was used to screen almost 90% of the mtDNA, including the control region (CR), for heteroplasmy in 62 children with CVS and neuromuscular disease (CVSþ) and in 95 control subjects. One or two rare mtDNA-CR heteroplasmic sequence variants were found in six CVSþ and in zero control subjects (P ¼ 0.003). These variants comprised 6 point and 2 length variants in hypervariable regions 1 and 2 (HV1 and HV2, both part of the mtDNA-CR), one half of which were clustered in the nt 16040-16188 segment of HV1 that includes the termination associated sequence (TAS), a functional location important in the regulation of mtDNA replication. Based upon our findings, sequencing and statistical analysis looking for homoplasmic nucleotide changes was performed in HV1 among 30 CVSþ, 30 randomlyascertained CVS (rCVS), 18 MA, 32 MO, and 35 control haplogroup H cases. Within the nt 16040-16188 segment, homoplasmic sequence variants were threefold more common relative to control subjects in both CVS groups (P ¼ 0.01 combined data) and in MO (P ¼ 0.02), but not in MA (P ¼ 0.5 vs. control subjects and 0.02 vs. MO). No group differences were noted in the remainder of HV1. We conclude that sequence variation in this small ''peri-TAS'' segment is associated with CVS and MO, but not MA. These variants likely constitute risk factors for disease development. Our findings are consistent with previous data demonstrating progression of CVS into MO in many cases, and the co-segregation in a maternal inheritance pattern of CVS and MO within families. A mitochondrial component in the pathogenesis of migraine and CVS has therapeutic implications, especially concerning the avoidance of fasting.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mitochondrial DNA-control region sequence variation in the NE Portuguese Jewish community","attachmentId":111688980,"attachmentType":"pdf","work_url":"https://www.academia.edu/115216645/Mitochondrial_DNA_control_region_sequence_variation_in_the_NE_Portuguese_Jewish_community","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/115216645/Mitochondrial_DNA_control_region_sequence_variation_in_the_NE_Portuguese_Jewish_community"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="2380370" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2380370/Two_Common_Mitochondrial_DNA_Polymorphisms_are_Highly_Associated_with_Migraine_Headache_and_Cyclic_Vomiting_Syndrome">Two Common Mitochondrial DNA Polymorphisms are Highly Associated with Migraine Headache and Cyclic Vomiting Syndrome</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Phytochemistry, 1990</p><p class="ds-related-work--abstract ds2-5-body-sm">Three hydroxycinnamic acid amides were isolated from the herb of Iochroma cyaneum and identified by means of spectral data and hydrolysis as caffeoylputrescine (paucine), feruloylputrescine (subaphylline) and the new N1,N10-di-dihydrocaffeoylspermidine.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Two Common Mitochondrial DNA Polymorphisms are Highly Associated with Migraine Headache and Cyclic Vomiting Syndrome","attachmentId":30546069,"attachmentType":"pdf","work_url":"https://www.academia.edu/2380370/Two_Common_Mitochondrial_DNA_Polymorphisms_are_Highly_Associated_with_Migraine_Headache_and_Cyclic_Vomiting_Syndrome","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2380370/Two_Common_Mitochondrial_DNA_Polymorphisms_are_Highly_Associated_with_Migraine_Headache_and_Cyclic_Vomiting_Syndrome"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="2380365" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2380365/Mitochondrial_Inheritance_in_One_Sixth_of_Adults_With_Irritable_Bowel_Syndrome">Mitochondrial Inheritance in One-Sixth of Adults With Irritable Bowel Syndrome</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cephalalgia, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mitochondrial Inheritance in One-Sixth of Adults With Irritable Bowel Syndrome","attachmentId":50650005,"attachmentType":"pdf","work_url":"https://www.academia.edu/2380365/Mitochondrial_Inheritance_in_One_Sixth_of_Adults_With_Irritable_Bowel_Syndrome","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2380365/Mitochondrial_Inheritance_in_One_Sixth_of_Adults_With_Irritable_Bowel_Syndrome"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="110244058" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/110244058/Whole_exome_genome_sequencing_in_cyclic_vomiting_syndrome_reveals_multiple_candidate_genes_suggesting_a_model_of_elevated_intracellular_cations_and_mitochondrial_dysfunction">Whole exome/genome sequencing in cyclic vomiting syndrome reveals multiple candidate genes, suggesting a model of elevated intracellular cations and mitochondrial dysfunction</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="113466954" href="https://camden-rutgers.academia.edu/OmriBar">Omri Bar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Neurology</p><p class="ds-related-work--abstract ds2-5-body-sm">ObjectiveTo utilize whole exome or genome sequencing and the scientific literature for identifying candidate genes for cyclic vomiting syndrome (CVS), an idiopathic migraine variant with paroxysmal nausea and vomiting.MethodsA retrospective chart review of 80 unrelated participants, ascertained by a quaternary care CVS specialist, was conducted. Genes associated with paroxysmal symptoms were identified querying the literature for genes associated with dominant cases of intermittent vomiting or both discomfort and disability; among which the raw genetic sequence was reviewed. “Qualifying” variants were defined as coding, rare, and conserved. Additionally, “Key Qualifying” variants were Pathogenic/Likely Pathogenic, or “Clinical” based upon the presence of a corresponding diagnosis. Candidate association to CVS was based on a point system.ResultsThirty-five paroxysmal genes were identified per the literature review. Among these, 12 genes were scored as “Highly likely” (SCN4A, CACNA1A,...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Whole exome/genome sequencing in cyclic vomiting syndrome reveals multiple candidate genes, suggesting a model of elevated intracellular cations and mitochondrial dysfunction","attachmentId":108120450,"attachmentType":"pdf","work_url":"https://www.academia.edu/110244058/Whole_exome_genome_sequencing_in_cyclic_vomiting_syndrome_reveals_multiple_candidate_genes_suggesting_a_model_of_elevated_intracellular_cations_and_mitochondrial_dysfunction","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/110244058/Whole_exome_genome_sequencing_in_cyclic_vomiting_syndrome_reveals_multiple_candidate_genes_suggesting_a_model_of_elevated_intracellular_cations_and_mitochondrial_dysfunction"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="12412089" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12412089/Increased_prevalence_of_two_mitochondrial_DNA_polymorphisms_in_functional_disease_Are_we_describing_different_parts_of_an_energy_depleted_elephant">Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--abstract ds2-5-body-sm">About 20% of the population suffers from“functional syndromes”. Since these syndromes overlap greatly in terms of co-morbidity, pathophysiology (including aberrant autonomic activity) and treatment responses, common predisposing genetic factors have been postulated. We had previously showed that two common mitochondrial DNA (mtDNA) polymorphisms at positions 16519 and 3010 are statistically associated with the functional syndromes of migraine, cyclic vomiting syndrome and non-specific abdominal pain. Herein, among individuals with mtDNA haplogroup H (HgH), the presence of these two mtDNA polymorphisms were ascertained in additional functional syndromes: chronic fatigue syndrome, complex regional pain syndrome, sudden infant death syndrome, and major depressive disorder. Polymorphic prevalence rateswere compared between disease and control groups, and within each disease group in participants with and without specific clinical findings. In all four conditions, one or both of the polymorphisms was significantly associated with the respective condition and/or co-morbid functional symptomatology. Thus, we conclude that these two mtDNA polymorphisms likely modify risk for the development of multiple functional syndromes, likely constituting a proportion of the postulated common genetic factor, at least among individuals with HgH. Pathophysiology likely involves broad effects on the autonomic nervous system.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?","attachmentId":37651685,"attachmentType":"pdf","work_url":"https://www.academia.edu/12412089/Increased_prevalence_of_two_mitochondrial_DNA_polymorphisms_in_functional_disease_Are_we_describing_different_parts_of_an_energy_depleted_elephant","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12412089/Increased_prevalence_of_two_mitochondrial_DNA_polymorphisms_in_functional_disease_Are_we_describing_different_parts_of_an_energy_depleted_elephant"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="80871829" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/80871829/Screening_of_the_A11084G_Polymorphism_and_Scanning_of_a_Mitochondrial_Genome_SNP_in_Korean_Migraineurs">Screening of the A11084G Polymorphism and Scanning of a Mitochondrial Genome SNP in Korean Migraineurs</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47251281" href="https://independent.academia.edu/ByungKunKim">ByungKun Kim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Clinical Neurology, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">Background and Purpose: Migraine is a genetically heterogeneous disorder that is frequently associated with a familial history, and mitochondrial dysfunction has been suggested to be associated with its pathogenesis. We screened and scanned mitochondrial gene polymorphisms to determine the significance of mitochondrial DNA mutations in Korean migraineurs. Methods: One hundred and sixty-four migraineurs aged 33.9±11.7 years (mean±SD range 12 to 65 years) were studied. Clinical data of the familial history were obtained, and blood samples were collected for DNA purification. An A-to-G substitution at mitochondrial DNA (mtDNA) position 11,084 (A11084G) was determined by a polymerase chain reaction (PCR) with BsmI restriction. In addition, new single-nucleotide polymorphism (SNP) sites in the mitochondrial genome were scanned for using PCR and direct sequencing. Results: Ninety-eight migraine patients (59.8%) had a maternal familial history. The A11084G polymorphism, which was previously reported in 25% of Japanese migraineurs, was not evident in our Korean migraine patients. However, scanning of new SNP sites in mtDNA revealed six candidate SNPs whose incidences were higher in migraine patients than in normal subjects. Conclusion: Our study found no association between the A11084G polymorphism in mitochondrial DNA and migraine in Koreans. However, we found potential new mitochondrial SNP sites in Korean migraineurs, which warrant further investigation.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Screening of the A11084G Polymorphism and Scanning of a Mitochondrial Genome SNP in Korean Migraineurs","attachmentId":87109399,"attachmentType":"pdf","work_url":"https://www.academia.edu/80871829/Screening_of_the_A11084G_Polymorphism_and_Scanning_of_a_Mitochondrial_Genome_SNP_in_Korean_Migraineurs","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/80871829/Screening_of_the_A11084G_Polymorphism_and_Scanning_of_a_Mitochondrial_Genome_SNP_in_Korean_Migraineurs"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":30546204,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":30546204,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_30546204" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="84644693" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84644693/A_Pilot_Mitochondrial_Genome_Wide_Association_on_Migraine_Among_Saudi_Arabians">A Pilot Mitochondrial Genome-Wide Association on Migraine Among Saudi Arabians</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="406809" href="https://iabfu.academia.edu/DrAbdulazeezsayed">Sayed Abdulazeez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of General Medicine</p><div 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="2380360" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2380360/51_A_common_mtDNA_control_region_polymorphism_16519T_is_associated_with_migraine_without_aura_and_cyclic_vomiting">51 A common mtDNA control region polymorphism 16519T is associated with migraine without aura and cyclic vomiting</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mitochondrion, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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Stovner</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The journal of headache and pain, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study","attachmentId":71370738,"attachmentType":"pdf","work_url":"https://www.academia.edu/55552227/The_association_between_headache_and_Val158Met_polymorphism_in_the_catechol_O_methyltransferase_gene_the_HUNT_Study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/55552227/The_association_between_headache_and_Val158Met_polymorphism_in_the_catechol_O_methyltransferase_gene_the_HUNT_Study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="109283567" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109283567/Are_Methylenetetrahydrofolate_Reductase_and_amp_lt_i_and_amp_gt_MTHFR_and_amp_lt_i_and_amp_gt_Gene_Polymorphisms_C677T_and_A1298C_Associated_with_Higher_Risk_of_Pediatric_Migraine_in_Boys_and_Girls">Are Methylenetetrahydrofolate Reductase (&amp;lt;i&amp;gt;MTHFR&amp;lt;/i&amp;gt;) Gene Polymorphisms C677T and A1298C Associated with Higher Risk of Pediatric Migraine in Boys and Girls?</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="199187342" href="https://independent.academia.edu/Lotman">Eno-Martin Lotman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biomedical Science and Engineering, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Are Methylenetetrahydrofolate Reductase (\u0026amp;lt;i\u0026amp;gt;MTHFR\u0026amp;lt;/i\u0026amp;gt;) Gene Polymorphisms C677T and A1298C Associated with Higher Risk of Pediatric Migraine in Boys and Girls?","attachmentId":107455437,"attachmentType":"pdf","work_url":"https://www.academia.edu/109283567/Are_Methylenetetrahydrofolate_Reductase_and_amp_lt_i_and_amp_gt_MTHFR_and_amp_lt_i_and_amp_gt_Gene_Polymorphisms_C677T_and_A1298C_Associated_with_Higher_Risk_of_Pediatric_Migraine_in_Boys_and_Girls","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/109283567/Are_Methylenetetrahydrofolate_Reductase_and_amp_lt_i_and_amp_gt_MTHFR_and_amp_lt_i_and_amp_gt_Gene_Polymorphisms_C677T_and_A1298C_Associated_with_Higher_Risk_of_Pediatric_Migraine_in_Boys_and_Girls"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="15" data-entity-id="2530855" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2530855/Mitochondrial_DNA_and_gastrointestinal_motor_and_sensory_functions_in_health_and_functional_gastrointestinal_disorders">Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American journal of physiology. 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ds2-5-body-link" data-author-id="39602793" href="https://independent.academia.edu/MireiaDelToro">Mireia Del Toro</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cephalalgia, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes","attachmentId":40565440,"attachmentType":"pdf","work_url":"https://www.academia.edu/19339379/Genetic_analysis_of_27_Spanish_patients_with_hemiplegic_migraine_basilar_type_migraine_and_childhood_periodic_syndromes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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