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(PDF) IDENTIFICATION OF mtDNA 7028C AND 16519T POLYMORPHISMS IN A PEDIATRIC-ONSET CYCLIC VOMITING SYNDROME (CVS) PATIENT | Tihomir Vachev - Academia.edu
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Limited","grobid_abstract":"Cyclic vomiting syndrome (CVS) is a functional disorder that may occur in any age group of patients. In the past the disorder was considered to be fairly uncommon, of unknown etiology. Most cases of CVS have been described as sporadic, but family history may be an important factor. Here we present an 18-year-old male patient with symptoms of recurrent spells of intense vomiting. The objective of this study was to determine the presence of mtDNA polymorphisms in a patient with a pediatric-onset CVS as an indication of genetic association that confers an increased risk towards disease pathogenesis.","publication_date":"2013,,","publication_name":"Biotechnology \u0026 Biotechnological Equipment","grobid_abstract_attachment_id":"97230722"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"IDENTIFICATION OF mtDNA 7028C AND 16519T POLYMORPHISMS IN A PEDIATRIC-ONSET CYCLIC VOMITING SYNDROME (CVS) PATIENT","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [185477111]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 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/><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">IDENTIFICATION OF mtDNA 7028C AND 16519T POLYMORPHISMS IN A PEDIATRIC-ONSET CYCLIC VOMITING SYNDROME (CVS) PATIENT</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="185477111" href="https://independent.academia.edu/TihomirVachev"><img alt="Profile image of Tihomir Vachev" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Tihomir Vachev</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2013, Biotechnology & Biotechnological Equipment</p></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":97230722,"attachmentType":"pdf","workUrl":"https://www.academia.edu/94898098/IDENTIFICATION_OF_mtDNA_7028C_AND_16519T_POLYMORPHISMS_IN_A_PEDIATRIC_ONSET_CYCLIC_VOMITING_SYNDROME_CVS_PATIENT"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":97230722,"attachmentType":"pdf","workUrl":"https://www.academia.edu/94898098/IDENTIFICATION_OF_mtDNA_7028C_AND_16519T_POLYMORPHISMS_IN_A_PEDIATRIC_ONSET_CYCLIC_VOMITING_SYNDROME_CVS_PATIENT"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="97230722" data-landing_url="https://www.academia.edu/94898098/IDENTIFICATION_OF_mtDNA_7028C_AND_16519T_POLYMORPHISMS_IN_A_PEDIATRIC_ONSET_CYCLIC_VOMITING_SYNDROME_CVS_PATIENT" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="8985463" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/8985463/Quantitative_pedigree_analysis_and_mitochondrial_DNA_sequence_variants_in_adults_with_cyclic_vomiting_syndrome">Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Abstract Background Children with cyclic vomiting syndrome (CVS) have a high degree of maternal inheritance of functional gastrointestinal and neurological disorders. CVS in children is also associated with an increased prevalence of mitochondrial DNA single-nucleotide polymorphisms (mtDNA SNPs) 16519 T and 3010A. Preliminary data suggests that age of onset of symptoms (pediatric vs. adult) may be a determinant of the presence of such mtDNA SNP’s. We sought to examine the degree of maternal inheritance pattern of functional disorders and the prevalence of mtDNA SNP’s16519T and 3010A in adults with CVS and correlate this with age of onset of disease. Methods A Quantitative Pedigree Analysis (QPA) was performed in 195 of a total of 216 patients and all were genotyped using Restriction Fragment Length Polymorphism (RFLP) or sequencing. Results Adults with CVS had a higher degree of probable maternal inheritance (PMI) of functional disorders than controls (12% vs. 1%, p < 0.001). However, the prevalence of mitochondrial SNP’s 16519 T, 3010A and the AT genotype were similar in Haplogroup H CVS patients compared to historical controls. There was no correlation between age of onset of disease and prevalence of these mtDNA SNP’s. Conclusions A subset of adults with CVS has a significantly higher degree of maternal inheritance pattern of functional disorders than controls. There was no association with mtDNA SNP’s 16519 T and 3010A as seen in children and future studies sequencing the entire mitochondrial and nuclear genome to identify potential causes for this maternal inheritance pattern in adults are warranted.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome","attachmentId":35299116,"attachmentType":"pdf","work_url":"https://www.academia.edu/8985463/Quantitative_pedigree_analysis_and_mitochondrial_DNA_sequence_variants_in_adults_with_cyclic_vomiting_syndrome","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/8985463/Quantitative_pedigree_analysis_and_mitochondrial_DNA_sequence_variants_in_adults_with_cyclic_vomiting_syndrome"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="2530854" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2530854/Are_pediatric_and_adult_onset_cyclic_vomiting_syndrome_CVS_biologically_different_conditions_Relationship_of_adult_onset_CVS_with_the_migraine_and_pediatric_CVS_associated_common_mtDNA_polymorphisms_16519T_and_3010A">Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A","attachmentId":30546204,"attachmentType":"pdf","work_url":"https://www.academia.edu/2530854/Are_pediatric_and_adult_onset_cyclic_vomiting_syndrome_CVS_biologically_different_conditions_Relationship_of_adult_onset_CVS_with_the_migraine_and_pediatric_CVS_associated_common_mtDNA_polymorphisms_16519T_and_3010A","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2530854/Are_pediatric_and_adult_onset_cyclic_vomiting_syndrome_CVS_biologically_different_conditions_Relationship_of_adult_onset_CVS_with_the_migraine_and_pediatric_CVS_associated_common_mtDNA_polymorphisms_16519T_and_3010A"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="33519466" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33519466/Mitochondrial_DNA_control_region_sequence_variation_in_migraine_headache_and_cyclic_vomiting_syndrome">Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="53651164" href="https://independent.academia.edu/LuisCalebMercadoAlvarez">Luis Caleb Mercado Alvarez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Medical Genetics, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome","attachmentId":53554929,"attachmentType":"pdf","work_url":"https://www.academia.edu/33519466/Mitochondrial_DNA_control_region_sequence_variation_in_migraine_headache_and_cyclic_vomiting_syndrome","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/33519466/Mitochondrial_DNA_control_region_sequence_variation_in_migraine_headache_and_cyclic_vomiting_syndrome"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="110244058" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/110244058/Whole_exome_genome_sequencing_in_cyclic_vomiting_syndrome_reveals_multiple_candidate_genes_suggesting_a_model_of_elevated_intracellular_cations_and_mitochondrial_dysfunction">Whole exome/genome sequencing in cyclic vomiting syndrome reveals multiple candidate genes, suggesting a model of elevated intracellular cations and mitochondrial dysfunction</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="113466954" href="https://camden-rutgers.academia.edu/OmriBar">Omri Bar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Neurology</p><p class="ds-related-work--abstract ds2-5-body-sm">ObjectiveTo utilize whole exome or genome sequencing and the scientific literature for identifying candidate genes for cyclic vomiting syndrome (CVS), an idiopathic migraine variant with paroxysmal nausea and vomiting.MethodsA retrospective chart review of 80 unrelated participants, ascertained by a quaternary care CVS specialist, was conducted. Genes associated with paroxysmal symptoms were identified querying the literature for genes associated with dominant cases of intermittent vomiting or both discomfort and disability; among which the raw genetic sequence was reviewed. “Qualifying” variants were defined as coding, rare, and conserved. Additionally, “Key Qualifying” variants were Pathogenic/Likely Pathogenic, or “Clinical” based upon the presence of a corresponding diagnosis. Candidate association to CVS was based on a point system.ResultsThirty-five paroxysmal genes were identified per the literature review. Among these, 12 genes were scored as “Highly likely” (SCN4A, CACNA1A,...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Whole exome/genome sequencing in cyclic vomiting syndrome reveals multiple candidate genes, suggesting a model of elevated intracellular cations and mitochondrial dysfunction","attachmentId":108120450,"attachmentType":"pdf","work_url":"https://www.academia.edu/110244058/Whole_exome_genome_sequencing_in_cyclic_vomiting_syndrome_reveals_multiple_candidate_genes_suggesting_a_model_of_elevated_intracellular_cations_and_mitochondrial_dysfunction","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/110244058/Whole_exome_genome_sequencing_in_cyclic_vomiting_syndrome_reveals_multiple_candidate_genes_suggesting_a_model_of_elevated_intracellular_cations_and_mitochondrial_dysfunction"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="12173425" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12173425/Similarities_In_Cyclic_Vomiting_Syndrome_Across_Age_Groups">Similarities In Cyclic Vomiting Syndrome Across Age Groups</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="30592043" href="https://independent.academia.edu/ChandraPrakash60">Chandra Prakash</a></div><p class="ds-related-work--metadata ds2-5-body-xs">… American journal of …, 2001</p><p class="ds-related-work--abstract ds2-5-body-sm">Chandra Prakash, MD, MRCP, Annamaria Staiano, MD, Robert J. Rothbaum, MD, and Ray E. Clouse, MD Divisions of Gastroenterology and Pediatric Gastroenterology & Nutrition, Washington University School of Medicine, St. Louis, Missouri; and Department of Pediatrics, ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Similarities In Cyclic Vomiting Syndrome Across Age Groups","attachmentId":46322569,"attachmentType":"pdf","work_url":"https://www.academia.edu/12173425/Similarities_In_Cyclic_Vomiting_Syndrome_Across_Age_Groups","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12173425/Similarities_In_Cyclic_Vomiting_Syndrome_Across_Age_Groups"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="98571727" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/98571727/Cyclic_Vomiting_Syndrome_CVS_is_there_a_difference_based_on_onset_of_symptoms_pediatric_versus_adult">Cyclic Vomiting Syndrome (CVS): is there a difference based on onset of symptoms - pediatric versus adult?</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="254085001" href="https://independent.academia.edu/naveenreddy491">naveen reddy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC Gastroenterology, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Background Cyclic Vomiting Syndrome (CVS) is a well-recognized functional gastrointestinal disorder in children but its presentation is poorly understood in adults. Genetic differences in pediatric-onset (presentation before age 18) and adult-onset CVS have been reported recently but their clinical features and possible differences in response to therapy have not been well studied. Methods This was a retrospective review of 101 CVS patients seen at the Medical College of Wisconsin between 2006 and 2008. Rome III criteria were utilized to make the diagnosis of CVS. Results Our study population comprised of 29(29%) pediatric-onset and 72 (71%) adult-onset CVS patients. Pediatric-onset CVS patients were more likely to be female (86% vs. 57%, p = 0.005) and had a higher prevalence of CVS plus (CVS + neurocognitive disorders) as compared to adult-onset CVS patients (14% vs. 3%, p = 0.05). There was a longer delay in diagnosis (10 ± 7 years) in the pediatric-onset group when compared to (...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cyclic Vomiting Syndrome (CVS): is there a difference based on onset of symptoms - pediatric versus adult?","attachmentId":99885571,"attachmentType":"pdf","work_url":"https://www.academia.edu/98571727/Cyclic_Vomiting_Syndrome_CVS_is_there_a_difference_based_on_onset_of_symptoms_pediatric_versus_adult","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/98571727/Cyclic_Vomiting_Syndrome_CVS_is_there_a_difference_based_on_onset_of_symptoms_pediatric_versus_adult"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="2380370" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2380370/Two_Common_Mitochondrial_DNA_Polymorphisms_are_Highly_Associated_with_Migraine_Headache_and_Cyclic_Vomiting_Syndrome">Two Common Mitochondrial DNA Polymorphisms are Highly Associated with Migraine Headache and Cyclic Vomiting Syndrome</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Phytochemistry, 1990</p><p class="ds-related-work--abstract ds2-5-body-sm">Three hydroxycinnamic acid amides were isolated from the herb of Iochroma cyaneum and identified by means of spectral data and hydrolysis as caffeoylputrescine (paucine), feruloylputrescine (subaphylline) and the new N1,N10-di-dihydrocaffeoylspermidine.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Two Common Mitochondrial DNA Polymorphisms are Highly Associated with Migraine Headache and Cyclic Vomiting Syndrome","attachmentId":30546071,"attachmentType":"pdf","work_url":"https://www.academia.edu/2380370/Two_Common_Mitochondrial_DNA_Polymorphisms_are_Highly_Associated_with_Migraine_Headache_and_Cyclic_Vomiting_Syndrome","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2380370/Two_Common_Mitochondrial_DNA_Polymorphisms_are_Highly_Associated_with_Migraine_Headache_and_Cyclic_Vomiting_Syndrome"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="2530855" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2530855/Mitochondrial_DNA_and_gastrointestinal_motor_and_sensory_functions_in_health_and_functional_gastrointestinal_disorders">Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American journal of physiology. Gastrointestinal and liver physiology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders","attachmentId":30546201,"attachmentType":"pdf","work_url":"https://www.academia.edu/2530855/Mitochondrial_DNA_and_gastrointestinal_motor_and_sensory_functions_in_health_and_functional_gastrointestinal_disorders","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2530855/Mitochondrial_DNA_and_gastrointestinal_motor_and_sensory_functions_in_health_and_functional_gastrointestinal_disorders"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="2380360" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2380360/51_A_common_mtDNA_control_region_polymorphism_16519T_is_associated_with_migraine_without_aura_and_cyclic_vomiting">51 A common mtDNA control region polymorphism 16519T is associated with migraine without aura and cyclic vomiting</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3070540" href="https://usc.academia.edu/EssamZaki">Essam Zaki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mitochondrion, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"51 A common mtDNA control region polymorphism 16519T is associated with migraine without aura and cyclic vomiting","attachmentId":50650024,"attachmentType":"pdf","work_url":"https://www.academia.edu/2380360/51_A_common_mtDNA_control_region_polymorphism_16519T_is_associated_with_migraine_without_aura_and_cyclic_vomiting","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2380360/51_A_common_mtDNA_control_region_polymorphism_16519T_is_associated_with_migraine_without_aura_and_cyclic_vomiting"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="17329730" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17329730/A_collection_of_33_novel_human_mtDNA_homoplasmic_variants">A collection of 33 novel human mtDNA homoplasmic variants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37040470" href="https://independent.academia.edu/IdaBiunno">Ida Biunno</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Mutation, 2002</p><div 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