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Aromatic Amines | Lhasa Limited
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class="site-content"> <div class="ast-container"> <div id="primary" class="content-area primary"> <main id="main" class="site-main"> <article class="post-1027 page type-page status-publish ast-article-single" id="post-1027" itemtype="https://schema.org/CreativeWork" itemscope="itemscope"> <header class="entry-header ast-no-title ast-header-without-markup"> </header> <!-- .entry-header --> <div class="entry-content clear" itemprop="text"> <div data-elementor-type="wp-page" data-elementor-id="1027" class="elementor elementor-1027" data-elementor-post-type="page"> <section data-dce-background-overlay-color="#FFFFFF00" data-dce-background-image-url="https://www.lhasalimited.org/wp-content/uploads/2022/11/solutions-banner-v2-scaled.jpg" class="elementor-section elementor-top-section elementor-element elementor-element-1c1d99 elementor-section-height-min-height elementor-section-items-top elementor-section-boxed elementor-section-height-default" data-id="1c1d99" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[]}"> <div class="elementor-background-overlay"></div> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-af13a1f" data-id="af13a1f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-1782a558 elementor-widget elementor-widget-heading" data-id="1782a558" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h1 class="elementor-heading-title elementor-size-default">Aromatic Amines</h1> </div> </div> <div class="elementor-element elementor-element-23546aef elementor-widget elementor-widget-text-editor" data-id="23546aef" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Advancing the understanding of Ames mutagenicity for primary aromatic amines</p> </div> </div> <div class="elementor-element elementor-element-4da892eb elementor-widget elementor-widget-button" data-id="4da892eb" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-11af68f3" data-id="11af68f3" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-5335c4e3 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="5335c4e3" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3f281780" data-id="3f281780" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <section class="elementor-section elementor-inner-section elementor-element elementor-element-7edd5f2f elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="7edd5f2f" data-element_type="section" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6b70ce23" data-id="6b70ce23" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-38b23f64 elementor-widget elementor-widget-text-editor" data-id="38b23f64" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Aromatic amines are widely used in the synthesis of pharmaceuticals, however some compounds from this class were found to have mutagenic activity, causing concern due to the risk of genotoxicity-related drug attrition.</p><p>Prediction of aromatic amine mutagenic activity remains a challenge within the pharmaceutical industry. The physico-chemical properties and the stability of the nitrenium ion formed via metabolic activation are key factors to consider when interpreting the Ames outcomes. Data sharing helps to challenge and clarify the rationale for mutagenic activity.</p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-7cdd92d elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible" data-id="7cdd92d" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[],"animation":"rotateInUpLeft"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3b333d6" data-id="3b333d6" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-7228d66 elementor-widget elementor-widget-heading" data-id="7228d66" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Our solution</h2> </div> </div> <div class="elementor-element elementor-element-61d9e40 elementor-widget elementor-widget-text-editor" data-id="61d9e40" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Launched in 2010, the <strong>Vitic Aromatic Amines data sharing initiative</strong> is a long-standing collaboration of pharmaceutical organisations sharing data from Ames mutagenicity assays for primary aromatic amines.</p> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-c80638b elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="c80638b" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"animation":"none"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4fac7cc" data-id="4fac7cc" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-f737d0e" data-id="f737d0e" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-78ebeff dce_masking-none elementor-widget elementor-widget-image" data-id="78ebeff" data-element_type="widget" data-settings="{"motion_fx_motion_fx_mouse":"yes"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="#vitic"> <img decoding="async" width="622" height="255" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_AROMATIC_AMINES_LOGO.png" class="elementor-animation-hang attachment-full size-full wp-image-2716" alt="VITIC AROMATIC AMINES LOGO" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_AROMATIC_AMINES_LOGO.png 622w, https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_AROMATIC_AMINES_LOGO-300x123.png 300w" sizes="(max-width: 622px) 100vw, 622px"> </a> </div> </div> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-d79612a" data-id="d79612a" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <div class="elementor-element elementor-element-ea5614c elementor-widget elementor-widget-text-editor" data-id="ea5614c" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>The <strong>initiative</strong> members share and access proprietary Ames data on primary aromatic amines, contributing towards the refinement of the structure-activity relationship (SAR) and as a result, the development of improved predictive tools.</p> </div> </div> <div class="elementor-element elementor-element-1053536 elementor-widget elementor-widget-menu-anchor" data-id="1053536" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div class="elementor-menu-anchor" id="vitic"></div> </div> </div> </div> </div> </div> </section> <section data-dce-background-color="#FFFFFF" class="elementor-section elementor-top-section elementor-element elementor-element-4cb929d elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="4cb929d" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"background_background":"gradient"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-66fdf32" data-id="66fdf32" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-1135a05 elementor-widget elementor-widget-heading" data-id="1135a05" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Key highlights</h2> </div> </div> <div class="elementor-element elementor-element-4bff01e1 elementor-widget elementor-widget-text-editor" data-id="4bff01e1" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;"><b>Contribute to industry progression</b></span></strong><br /><span style="font-weight: 400;">By participating in the Consortium for the Investigation of the Genotoxicity of Aromatic Amines (CIGAA), members are actively helping the progression towards an improved understanding and predictability of the Ames test outcome for this challenging chemical class.</span></p> </div> </div> <div class="elementor-element elementor-element-2f568090 elementor-widget elementor-widget-text-editor" data-id="2f568090" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;"><b>Enable a seamless search experience</b></span></strong><br /><span style="font-weight: 400;">The secure user management system allows cross-database searches to consider the published data in parallel to the Aromatic Amines proprietary data. The ability to search for chemically similar compounds enables read-across studies to be performed quickly and easily.</span></p> </div> </div> <div class="elementor-element elementor-element-798b7d3f elementor-widget elementor-widget-text-editor" data-id="798b7d3f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;"><b>Reduce the need to carry out testing and streamline your workflow</b></span></strong><br /><span style="font-weight: 400;">The sharing of aromatic amines Ames data reduces testing duplication, avoiding the need to repeat potentially costly experiments. The shared data can inform decisions in the synthesis planning process, allowing users to avoid problematic compounds and unnecessary testing.</span></p> </div> </div> <div class="elementor-element elementor-element-f27b0f8 elementor-align-left elementor-widget elementor-widget-button" data-id="f27b0f8" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-1dec9ea3 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="1dec9ea3" data-element_type="section" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4130995" data-id="4130995" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-1d6f60f9 elementor-widget elementor-widget-heading" data-id="1d6f60f9" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Regulatory support</h2> </div> </div> <div class="elementor-element elementor-element-71dea344 elementor-position-left elementor-view-default elementor-mobile-position-top elementor-vertical-align-top elementor-widget elementor-widget-icon-box" data-id="71dea344" data-element_type="widget" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div 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class="cls-4" d="M156.14,168.54c31.4,0,62.81-.03,94.21,.02,9.37,.01,15.35,7.7,12.43,15.86-1.74,4.86-5.36,7.45-10.43,8.01-1.32,.15-2.66,.07-3.99,.07-61.74,0-123.48,0-185.22,0-9.58,0-15.15-4.41-15.15-11.98,0-7.57,5.57-11.98,15.15-11.98,31,0,62.01,0,93.01,0Z"></path><path class="cls-2" d="M133.78,240.41c-24.34,0-48.67,.05-73.01-.03-9.21-.03-15.11-8.1-11.97-16.17,1.74-4.48,5.16-6.97,9.88-7.65,1.05-.15,2.12-.1,3.19-.1,48.14,0,96.28,0,144.42,0,6.84,0,11.48,2.92,13.19,8.19,2.58,7.97-3.11,15.66-11.88,15.73-15.03,.12-30.05,.03-45.08,.04-9.57,0-19.15,0-28.72,0Z"></path><path class="cls-3" d="M203.42,96.66c-15.7,0-31.4,.02-47.1,0-5.29,0-9.27-2.35-11.47-7.17-2-4.37-1.66-9,1.82-12.21,2.44-2.24,6.14-4.34,9.3-4.37,31.8-.32,63.6-.24,95.4-.15,6.91,.02,12.03,5.22,12.13,11.75,.1,6.69-5.1,12.05-12.18,12.1-15.97,.12-31.93,.04-47.9,.04Z"></path><path class="cls-6" d="M203.94,120.63c15.7,0,31.4-.09,47.1,.04,9.09,.07,14.94,8.53,11.51,16.49-2.17,5.03-6.25,7.42-11.7,7.42-13.04,.01-26.08,0-39.12,0-18.36,0-36.72,.06-55.08-.03-9.39-.04-15.41-8.4-11.91-16.5,2.25-5.2,6.49-7.45,12.1-7.44,15.7,.04,31.4,.01,47.1,.01Z"></path><path class="cls-5" d="M300.27,333.02c7.91-8.36,14.75-15.78,21.8-23,5.94-6.09,11.98-12.1,18.19-17.9,7.21-6.74,17.75-3.92,20.24,5.25,1.19,4.38,0,8.28-3.11,11.37-16.24,16.1-32.5,32.19-48.93,48.09-4.94,4.79-11.44,4.66-16.53-.09-8.36-7.8-16.57-15.76-24.65-23.85-4.97-4.98-4.97-12.01-.42-16.85,4.5-4.79,11.53-5.04,16.85-.43,2.81,2.43,5.47,5.06,8.04,7.75,2.57,2.69,4.94,5.58,8.53,9.67Z"></path></svg> </span> </div> <div class="elementor-icon-box-content"> <h3 class="elementor-icon-box-title"> <span > ICH M7 </span> </h3> <p class="elementor-icon-box-description"> This structural class main mutagenicity pathway is through metabolic activation with the formation of the reactive nitrenium ion. ICH M7 guideline outlines recommendations for the assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals. Having access to proprietary data through the Aromatic Amines data sharing initiative, enables a more informed expert assessment. Finding relevant supporting examples for your impurities by structure, substructure or similarity searching can add weight to expert review for regulatory submission under ICH M7. </p> </div> </div> </div> </div> <div class="elementor-element elementor-element-4d5f1788 elementor-align-center elementor-widget elementor-widget-button" data-id="4d5f1788" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-4c4a463 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="4c4a463" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"background_background":"classic"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1f0ce03" data-id="1f0ce03" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-ebf4857 elementor-widget elementor-widget-heading" data-id="ebf4857" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Related publications</h2> </div> </div> <div class="elementor-element elementor-element-6acffa1 premium-cursor-icon premium-gbadge-stripe premium-gbadge-row premium-gbadge-right premium-gbadge-top elementor-widget elementor-widget-jet-listing-grid" data-id="6acffa1" data-element_type="widget" data-settings="{"columns":"1"}" 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data-settings="{"jet_parallax_layout_list":[],"background_background":"classic"}"> <div class="elementor-container elementor-column-gap-default"> <div class="make-column-clickable-elementor elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4222da16" style="cursor: pointer;" data-column-clickable="https://www.lhasalimited.org/publications/a-pharma-wide-approach-to-address-the-genotoxicity-prediction-of-primary-aromatic-amines/" data-column-clickable-blank="_self" data-id="4222da16" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div data-dce-advanced-background-color="#14B5E1" class="elementor-element elementor-element-cc2be11 elementor-widget__width-initial elementor-absolute elementor-widget elementor-widget-heading" data-id="cc2be11" data-element_type="widget" data-settings="{"_position":"absolute"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <p class="elementor-heading-title elementor-size-small">Paper</p> </div> </div> <div class="elementor-element elementor-element-3181d5ac elementor-widget elementor-widget-heading" data-id="3181d5ac" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <p class="elementor-heading-title elementor-size-default"><a href="https://www.lhasalimited.org/publications/a-pharma-wide-approach-to-address-the-genotoxicity-prediction-of-primary-aromatic-amines/">A pharma-wide approach to address the genotoxicity prediction of primary aromatic amines. </a></p> </div> </div> <div class="elementor-element elementor-element-570e2eb6 elementor-icon-list--layout-inline elementor-align-left elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list" data-id="570e2eb6" data-element_type="widget" data-widget_type="icon-list.default"> <div class="elementor-widget-container"> <ul class="elementor-icon-list-items elementor-inline-items"> <li class="elementor-icon-list-item elementor-inline-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="far fa-calendar-alt"></i> </span> <span class="elementor-icon-list-text">Aug 2018</span> </li> <li class="elementor-icon-list-item elementor-inline-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="fas fa-tv"></i> </span> <span class="elementor-icon-list-text"><span>Aromatic Amines</span>, <span>Data sharing</span></span> </li> </ul> </div> </div> </div> </div> </div> </section> </div> </div></div></div> </div> </div> <div class="elementor-element elementor-element-a7859e7 elementor-align-center elementor-widget elementor-widget-button" data-id="a7859e7" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" 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premium-blog-none-effect"> <a href="https://www.lhasalimited.org/blog/lhasa-interviews-2023-richard-williams-award-winner/" target="_self"> <img decoding="async" width="1080" height="864" src="https://www.lhasalimited.org/wp-content/uploads/2024/10/A-new-life-in-Leeds-at-Lhasa-8.png" class="attachment-full size-full wp-image-11718" alt="A new life in Leeds at Lhasa 8" srcset="https://www.lhasalimited.org/wp-content/uploads/2024/10/A-new-life-in-Leeds-at-Lhasa-8.png 1080w, https://www.lhasalimited.org/wp-content/uploads/2024/10/A-new-life-in-Leeds-at-Lhasa-8-300x240.png 300w, https://www.lhasalimited.org/wp-content/uploads/2024/10/A-new-life-in-Leeds-at-Lhasa-8-1024x819.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2024/10/A-new-life-in-Leeds-at-Lhasa-8-768x614.png 768w" sizes="(max-width: 1080px) 100vw, 1080px" /> </a> </div> <div class="premium-blog-effect-container premium-blog-none-effect"> <a class="premium-blog-post-link" 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Mirabilis is our …</p> </div> <div class="premium-blog-entry-meta"> </div> </div> </div> </div> <div class="premium-blog-post-outer-container" data-total="27"> <div class="premium-blog-post-container premium-blog-skin-cards"> <div class="premium-blog-thumb-effect-wrapper"> <div class="premium-blog-thumbnail-container premium-blog-none-effect"> <a href="https://www.lhasalimited.org/blog/eurotox-2024-advancing-toxicology-in-copenhagen/" target="_self"> <img loading="lazy" decoding="async" width="1080" height="864" src="https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog.jpg" class="attachment-full size-full wp-image-11241" alt="EUROTOX 2024: A memorable gathering in Copenhagen" srcset="https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog.jpg 1080w, https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog-300x240.jpg 300w, https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog-1024x819.jpg 1024w, https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog-768x614.jpg 768w" sizes="(max-width: 1080px) 100vw, 1080px" /> </a> </div> <div class="premium-blog-effect-container premium-blog-none-effect"> <a class="premium-blog-post-link" href="https://www.lhasalimited.org/blog/eurotox-2024-advancing-toxicology-in-copenhagen/" target="_self"><span>EUROTOX 2024: Advancing toxicology in Copenhagen</span></a> </div> </div> <div class="premium-blog-content-wrapper "> <div class="premium-blog-inner-container"> <h2 class="premium-blog-entry-title"> <a href="https://www.lhasalimited.org/blog/eurotox-2024-advancing-toxicology-in-copenhagen/" target="_self"> EUROTOX 2024: Advancing toxicology in Copenhagen </a> </h2> </div> <div class="premium-blog-content-inner-wrapper"> <p class="premium-blog-post-content">We had a fantastic time at EUROTOX 2024, held from 8 – 11th September in the picturesque city of Copenhagen, Denmark. 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class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Sign up to our newsletter</h2> </div> </div> <div class="elementor-element elementor-element-b622827 eael-gravity-form-button-full-width elementor-widget elementor-widget-eael-gravity-form" data-id="b622827" data-element_type="widget" data-widget_type="eael-gravity-form.default"> <div class="elementor-widget-container"> <div class="eael-contact-form eael-gravity-form labels-hide eael-contact-form-align-default"> <script type="text/javascript"></script> <div class='gf_browser_ie gf_browser_ie7 gform_wrapper gravity-theme gform-theme--no-framework' data-form-theme='gravity-theme' data-form-index='0' id='gform_wrapper_8' ><form method='post' enctype='multipart/form-data' id='gform_8' action='/data-sharing/aromatic-amines/' data-formid='8' novalidate> <div class='gform-body gform_body'><div id='gform_fields_8' class='gform_fields top_label form_sublabel_below description_below validation_below'><fieldset id="field_8_4" class="gfield gfield--type-name gfield--input-type-name gfield--width-full gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_4" ><legend class='gfield_label gform-field-label gfield_label_before_complex' >Name<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></legend><div class='ginput_complex ginput_container ginput_container--name no_prefix has_first_name no_middle_name has_last_name no_suffix gf_name_has_2 ginput_container_name gform-grid-row' id='input_8_4'> <span id='input_8_4_3_container' class='name_first gform-grid-col gform-grid-col--size-auto' > <input type='text' name='input_4.3' id='input_8_4_3' value='' aria-required='true' placeholder='First name' /> <label for='input_8_4_3' class='gform-field-label gform-field-label--type-sub '>First</label> </span> <span id='input_8_4_6_container' class='name_last gform-grid-col gform-grid-col--size-auto' > <input type='text' name='input_4.6' id='input_8_4_6' value='' aria-required='true' placeholder='Last name' /> <label for='input_8_4_6' class='gform-field-label gform-field-label--type-sub '>Last</label> </span> </div></fieldset><div id="field_8_5" class="gfield gfield--type-email gfield--input-type-email gfield--width-full gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_5" ><label class='gfield_label gform-field-label' for='input_8_5'>Email<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_email'> <input name='input_5' id='input_8_5' type='email' value='' class='large' placeholder='Business email address' aria-required="true" aria-invalid="false" /> </div></div><div id="field_8_7" class="gfield gfield--type-text gfield--input-type-text gfield--width-full gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_7" ><label class='gfield_label gform-field-label' for='input_8_7'>What country are you based in?<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_text'><input name='input_7' id='input_8_7' type='text' value='' class='large' placeholder='What country are you based in?' aria-required="true" aria-invalid="false" /> </div></div><div id="field_8_6" class="gfield gfield--type-hidden gfield--input-type-hidden gfield--width-full gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_6" ><div class='ginput_container ginput_container_text'><input name='input_6' id='input_8_6' type='hidden' class='gform_hidden' aria-invalid="false" value='' /></div></div><div id="field_8_24" class="gfield gfield--type-hidden gfield--input-type-hidden gfield--width-full gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_24" ><div class='ginput_container ginput_container_text'><input name='input_24' id='input_8_24' type='hidden' class='gform_hidden' aria-invalid="false" value='Opt-in New Contact' /></div></div><div id="field_8_8" class="gfield gfield--type-hidden gfield--input-type-hidden gfield--width-full gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_8" ><div class='ginput_container ginput_container_text'><input name='input_8' id='input_8_8' type='hidden' class='gform_hidden' aria-invalid="false" value='Unknown/Event Registration' /></div></div><fieldset id="field_8_11" class="gfield gfield--type-checkbox gfield--type-choice gfield--input-type-checkbox gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_hidden" data-js-reload="field_8_11" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><legend class='gfield_label gform-field-label gfield_label_before_complex' >GDPR Compliant</legend><div class='ginput_container ginput_container_checkbox'><div class='gfield_checkbox' id='input_8_11'><div class='gchoice gchoice_8_11_1'> <input class='gfield-choice-input' name='input_11.1' type='checkbox' value='Yes' checked='checked' id='choice_8_11_1' /> <label for='choice_8_11_1' id='label_8_11_1' class='gform-field-label gform-field-label--type-inline'>Yes</label> </div></div></div></fieldset><div id="field_8_17" class="gfield gfield--type-select gfield--input-type-select gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_hidden" data-js-reload="field_8_17" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><label class='gfield_label gform-field-label' for='input_8_17'>Publications</label><div class='ginput_container ginput_container_select'><select name='input_17' id='input_8_17' class='large gfield_select' aria-invalid="false" ><option value='True' selected='selected'>True</option></select></div></div><div id="field_8_18" class="gfield gfield--type-select gfield--input-type-select gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_hidden" data-js-reload="field_8_18" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><label class='gfield_label gform-field-label' for='input_8_18'>Upcoming Events</label><div class='ginput_container ginput_container_select'><select name='input_18' id='input_8_18' class='large gfield_select' aria-invalid="false" ><option value='True' selected='selected'>True</option></select></div></div><div id="field_8_20" class="gfield gfield--type-select gfield--input-type-select gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_hidden" data-js-reload="field_8_20" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><label class='gfield_label gform-field-label' for='input_8_20'>Surveys</label><div class='ginput_container ginput_container_select'><select name='input_20' id='input_8_20' class='large gfield_select' aria-invalid="false" ><option value='True' selected='selected'>True</option></select></div></div><div id="field_8_19" class="gfield gfield--type-select gfield--input-type-select gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_hidden" data-js-reload="field_8_19" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><label class='gfield_label gform-field-label' for='input_8_19'>Lhasa Newsletter</label><div class='ginput_container ginput_container_select'><select name='input_19' id='input_8_19' class='large gfield_select' aria-invalid="false" ><option value='True' selected='selected'>True</option></select></div></div><div id="field_8_10" class="gfield gfield--type-hidden gfield--input-type-hidden gfield--width-full gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_10" ><div class='ginput_container ginput_container_text'><input name='input_10' id='input_8_10' type='hidden' class='gform_hidden' aria-invalid="false" value='Subscribed to Lhasa marketing newsletter:' /></div></div><div id="field_8_9" class="gfield gfield--type-hidden gfield--input-type-hidden gfield--width-full gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_9" ><div class='ginput_container ginput_container_text'><input name='input_9' id='input_8_9' type='hidden' class='gform_hidden' aria-invalid="false" value='Legitimate Interest' /></div></div><div id="field_8_16" class="gfield gfield--type-hidden gfield--input-type-hidden gfield--width-full gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_16" ><div class='ginput_container ginput_container_text'><input name='input_16' id='input_8_16' type='hidden' class='gform_hidden' aria-invalid="false" value='Web Form' /></div></div><div id="field_8_22" class="gfield gfield--type-date gfield--input-type-date gfield--input-type-datepicker gfield--datepicker-no-icon gfield--width-full gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_hidden" data-js-reload="field_8_22" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><label class='gfield_label gform-field-label' for='input_8_22'>Compliant Date<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_date'> <input name='input_22' id='input_8_22' type='text' value='//' class='datepicker gform-datepicker dmy datepicker_no_icon gdatepicker-no-icon' placeholder='dd/mm/yyyy' aria-describedby="input_8_22_date_format" aria-invalid="false" aria-required="true"/> <span id='input_8_22_date_format' class='screen-reader-text'>DD slash MM slash YYYY</span> </div> <input type='hidden' id='gforms_calendar_icon_input_8_22' class='gform_hidden' value='https://www.lhasalimited.org/wp-content/plugins/gravityforms/images/datepicker/datepicker.svg'/></div><div id="field_8_23" class="gfield gfield--type-captcha gfield--input-type-captcha gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_23" ><label class='gfield_label gform-field-label' for='input_8_23'>CAPTCHA</label><div id='input_8_23' class='ginput_container ginput_recaptcha' data-sitekey='6Ldf3jolAAAAAEs47ai9Mz-CccpxB3ke74BDLUNQ' data-theme='light' data-tabindex='0' data-badge=''></div></div><div id="field_8_25" class="gfield gfield--type-honeypot gform_validation_container field_sublabel_below gfield--has-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_8_25" ><label class='gfield_label gform-field-label' for='input_8_25'>Email</label><div class='ginput_container'><input name='input_25' id='input_8_25' type='text' value='' autocomplete='new-password'/></div><div class='gfield_description' id='gfield_description_8_25'>This field is for validation purposes and should be left unchanged.</div></div></div></div> <div class='gform_footer top_label'> <input type='submit' id='gform_submit_button_8' class='gform_button button' value='Sign up' onclick='if(window["gf_submitting_8"]){return false;} if( !jQuery("#gform_8")[0].checkValidity || jQuery("#gform_8")[0].checkValidity()){window["gf_submitting_8"]=true;} ' onkeypress='if( event.keyCode == 13 ){ if(window["gf_submitting_8"]){return false;} if( !jQuery("#gform_8")[0].checkValidity || jQuery("#gform_8")[0].checkValidity()){window["gf_submitting_8"]=true;} jQuery("#gform_8").trigger("submit",[true]); }' /> <input type='hidden' class='gform_hidden' name='is_submit_8' value='1' /> <input type='hidden' class='gform_hidden' name='gform_submit' value='8' /> <input type='hidden' 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class="elementor-menu-anchor" id="newsletter"></div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-3ee9436 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="3ee9436" data-element_type="section" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-d227c64" data-id="d227c64" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-9c24236 elementor-widget elementor-widget-text-editor" data-id="9c24236" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>© 2024 Lhasa Limited, All rights reserved | Company registration number: 01765239 | <br />VAT number: 396 8737 77 | Registered charity number: 290866 | <a href="https://www.lhasalimited.org/governing-documents/">Governing documents</a></p> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-643e93e" data-id="643e93e" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-2374aba elementor-widget__width-initial elementor-widget elementor-widget-shortcode" data-id="2374aba" data-element_type="widget" data-widget_type="shortcode.default"> <div class="elementor-widget-container"> <div class="elementor-shortcode"><div id="google_language_translator" class="default-language-en"></div></div> </div> </div> <div class="elementor-element elementor-element-412436c elementor-widget__width-auto elementor-widget elementor-widget-heading" data-id="412436c" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Connect with us</h2> </div> </div> <div class="elementor-element elementor-element-9949b01 e-grid-align-right elementor-shape-circle e-grid-align-mobile-left elementor-widget__width-auto elementor-grid-0 elementor-widget elementor-widget-social-icons" data-id="9949b01" data-element_type="widget" data-widget_type="social-icons.default"> <div class="elementor-widget-container"> <div class="elementor-social-icons-wrapper elementor-grid"> <span class="elementor-grid-item"> <a class="elementor-icon elementor-social-icon elementor-social-icon-linkedin-in elementor-repeater-item-76c4f32" href="https://www.linkedin.com/company/lhasa-limited" target="_blank"> <span class="elementor-screen-only">Linkedin-in</span> <i class="fab fa-linkedin-in"></i> </a> </span> <span class="elementor-grid-item"> <a class="elementor-icon elementor-social-icon elementor-social-icon- elementor-repeater-item-9d249a7" href="https://www.twitter.com/LhasaLimited" target="_blank"> <span class="elementor-screen-only"></span> <svg xmlns:svg="http://www.w3.org/2000/svg" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" id="svg5" x="0px" y="0px" viewBox="0 0 1668.56 1221.19" style="enable-background:new 0 0 1668.56 1221.19;" xml:space="preserve"><g id="layer1" transform="translate(52.390088,-25.058597)"> <path id="path1009" d="M283.94,167.31l386.39,516.64L281.5,1104h87.51l340.42-367.76L984.48,1104h297.8L874.15,558.3l361.92-390.99 h-87.51l-313.51,338.7l-253.31-338.7H283.94z M412.63,231.77h136.81l604.13,807.76h-136.81L412.63,231.77z"></path></g></svg> </a> </span> <span class="elementor-grid-item"> <a class="elementor-icon elementor-social-icon elementor-social-icon-instagram elementor-repeater-item-4b22734" href="https://www.instagram.com/LhasaLimited" target="_blank"> <span class="elementor-screen-only">Instagram</span> <i class="fab fa-instagram"></i> </a> </span> </div> </div> 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