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class="elementor-item menu-link" tabindex="-1">Contact us</a></li> </ul> </nav> </div> </div> </div> </div> </div> </section> </div> <div id="content" class="site-content"> <div class="ast-container"> <div id="primary" class="content-area primary"> <main id="main" class="site-main"> <article class="post-1010 page type-page status-publish ast-article-single" id="post-1010" itemtype="https://schema.org/CreativeWork" itemscope="itemscope"> <header class="entry-header ast-no-title ast-header-without-markup"> </header>  <div class="entry-content clear" itemprop="text"> <div data-elementor-type="wp-page" data-elementor-id="1010" class="elementor elementor-1010" data-elementor-post-type="page"> <section data-dce-background-overlay-color="#FFFFFF00" data-dce-background-image-url="https://www.lhasalimited.org/wp-content/uploads/2022/11/solutions-banner-v2-scaled.jpg" class="elementor-section elementor-top-section elementor-element elementor-element-23e1e34 elementor-section-height-min-height elementor-section-items-top elementor-section-boxed elementor-section-height-default" data-id="23e1e34" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[]}"> <div class="elementor-background-overlay"></div> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2da550c" data-id="2da550c" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-6862e4f elementor-widget elementor-widget-heading" data-id="6862e4f" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h1 class="elementor-heading-title elementor-size-default">Skin sensitisation assessment</h1> </div> </div> <div class="elementor-element elementor-element-19600e5 elementor-widget elementor-widget-text-editor" data-id="19600e5" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Evaluating the skin sensitisation potential and potency of chemicals</p> </div> </div> <div class="elementor-element elementor-element-25540ab elementor-widget elementor-widget-button" data-id="25540ab" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-dccf70d" data-id="dccf70d" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-1db6730 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="1db6730" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ee74795" data-id="ee74795" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <section class="elementor-section elementor-inner-section elementor-element elementor-element-4de5ee3 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="4de5ee3" data-element_type="section" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5483bc3" data-id="5483bc3" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-2e45a38 elementor-widget elementor-widget-text-editor" data-id="2e45a38" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Historically, the skin sensitisation potential and potency of substances have been mainly assessed by <em>in vivo</em> studies on animals.</p> </div> </div> <div class="elementor-element elementor-element-b3228a6 elementor-widget elementor-widget-text-editor" data-id="b3228a6" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Various regulations and guidelines have introduced measures to encourage the phasing out of animal testing, this has prompted the development and use of non-animal methods to identify potential skin sensitisers – chemical substances that cause an allergic reaction following skin contact.</p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-06c522d elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible" data-id="06c522d" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[],"animation":"rotateInUpLeft"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a3b90b4" data-id="a3b90b4" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-3b52000 elementor-widget elementor-widget-heading" data-id="3b52000" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Our solution</h2> </div> </div> <div class="elementor-element elementor-element-565ea39 elementor-widget elementor-widget-text-editor" data-id="565ea39" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span style="font-weight: 400;">We offer our <em>in silico</em> software solutions; Derek Nexus, Vitic and Skin sensitisation Defined Approach ITSv1 for use in your skin sensitisation assessments, and as an alternative to animal testing.</span></p> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-58f8d86 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="58f8d86" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"animation":"none"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-b11b917" data-id="b11b917" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-62a51d1 dce_masking-none elementor-widget elementor-widget-image" data-id="62a51d1" data-element_type="widget" data-settings="{"motion_fx_motion_fx_mouse":"yes"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="#Derek"> <img decoding="async" width="1024" height="381" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-1024x381.png" class="elementor-animation-hang attachment-large size-large wp-image-2667" alt="derek logo" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-1024x381.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-300x112.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-768x286.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-1536x571.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-2048x762.png 2048w" sizes="(max-width: 1024px) 100vw, 1024px"> </a> </div> </div> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-9ab4e09" data-id="9ab4e09" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-8b0152e dce_masking-none elementor-widget elementor-widget-image" data-id="8b0152e" data-element_type="widget" data-settings="{"motion_fx_motion_fx_mouse":"yes"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="#Vitic"> <img decoding="async" width="2068" height="769" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1.png" class="elementor-animation-hang attachment-full size-full wp-image-2668" alt="vitic logo 1" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1.png 2068w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-300x112.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-1024x381.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-768x286.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-1536x571.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-2048x762.png 2048w" sizes="(max-width: 2068px) 100vw, 2068px"> </a> </div> </div> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-c4a225a" data-id="c4a225a" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-e7e7b35 dce_masking-none elementor-widget elementor-widget-image" data-id="e7e7b35" data-element_type="widget" data-settings="{"motion_fx_motion_fx_mouse":"yes"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="#Skin-Sensitisation"> <img loading="lazy" decoding="async" width="1460" height="602" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/skin-sensitisation-logo.png" class="elementor-animation-hang attachment-full size-full wp-image-2665" alt="skin sensitisation logo" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/skin-sensitisation-logo.png 1460w, https://www.lhasalimited.org/wp-content/uploads/2022/11/skin-sensitisation-logo-300x124.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/skin-sensitisation-logo-1024x422.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/skin-sensitisation-logo-768x317.png 768w" sizes="(max-width: 1460px) 100vw, 1460px"> </a> </div> </div> </div> </div> </div> </section> <div class="elementor-element elementor-element-95b9e0f elementor-widget elementor-widget-menu-anchor" data-id="95b9e0f" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div class="elementor-menu-anchor" id="Derek"></div> </div> </div> </div> </div> </div> </section> <section data-dce-background-color="#FFFFFF" class="elementor-section elementor-top-section elementor-element elementor-element-e61b5d4 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="e61b5d4" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"background_background":"gradient"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-cd82336" data-id="cd82336" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-e9e4ab8" data-id="e9e4ab8" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-9dd4ad7 dce_masking-none elementor-widget elementor-widget-image" data-id="9dd4ad7" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="2382" height="810" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO.png" class="attachment-full size-full wp-image-1556" alt="DEREK LOGO" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO.png 2382w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-300x102.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-1024x348.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-768x261.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-1536x522.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-2048x696.png 2048w" sizes="(max-width: 2382px) 100vw, 2382px"> </div> </div> <div class="elementor-element elementor-element-1d2b3c9 elementor-widget elementor-widget-text-editor" data-id="1d2b3c9" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Derek Nexus</strong> contains well-established Structure-Activity Relationship (SAR) knowledge, which can help you to assess the skin sensitisation potential and potency of chemicals.</p> </div> </div> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-b84b643" data-id="b84b643" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-6ccecfd elementor-widget elementor-widget-heading" data-id="6ccecfd" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Derek Nexus highlights</h2> </div> </div> <div class="elementor-element elementor-element-b16cf4c elementor-widget elementor-widget-text-editor" data-id="b16cf4c" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;">Access potency predictions and negative predictions</span></strong><br /><span style="font-weight: 400;">Extrapolating hazard identification to risk, Derek Nexus provides EC3 predictions to inform potency. Negative predictions allow confidence when classifying a compound as a non-sensitiser, when query compounds do not fire any skin sensitisation alerts.</span></p> </div> </div> <div class="elementor-element elementor-element-1e0739b elementor-widget elementor-widget-text-editor" data-id="1e0739b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;">Identify strong/extreme sensitisers of particular concern</span></strong><br /><span style="font-weight: 400;">High Potency Category (HPC) alerts consist of a set of structural features within a mechanistic domain which are likely to be associated with extreme skin sensitisation potential in the Local Lymph Node Assay (LLNA). The presence or absence of alerts for skin sensitisation HPC provides information about which of the Dermal Sensitisation Thresholds (DSTs) is the most appropriate to use.</span></p> </div> </div> <div class="elementor-element elementor-element-158cb39 elementor-widget elementor-widget-text-editor" data-id="158cb39" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;">Use as part of a defined approach</span></strong><br /><span style="font-weight: 400;">The use of Derek Nexus with </span><i><span style="font-weight: 400;">in vitro</span></i><span style="font-weight: 400;"> assays and </span><i><span style="font-weight: 400;">in chemico </span></i><span style="font-weight: 400;">assays can predict the skin sensitisation potential of chemicals. One of the three approved defined approaches mentioned within OECD Guideline No.497, ITSv1 (Integrated Testing Strategy version 1) by Kao, includes Derek Nexus as a required information source.</span></p> </div> </div> <div class="elementor-element elementor-element-ff20238 elementor-align-left elementor-widget elementor-widget-button" data-id="ff20238" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> <div class="elementor-element elementor-element-fa4cb53 elementor-widget elementor-widget-menu-anchor" data-id="fa4cb53" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div class="elementor-menu-anchor" id="Vitic"></div> </div> </div> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-21f8c80" data-id="21f8c80" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-9491181 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="9491181" data-element_type="section" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-b2c70a2" data-id="b2c70a2" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-9f3b2d7" data-id="9f3b2d7" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-1a79baa dce_masking-none elementor-widget elementor-widget-image" data-id="1a79baa" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="2463" height="922" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_COLOUR_LOGO.png" class="attachment-full size-full wp-image-1578" alt="VITIC COLOUR LOGO" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_COLOUR_LOGO.png 2463w, https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_COLOUR_LOGO-300x112.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_COLOUR_LOGO-1024x383.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_COLOUR_LOGO-768x287.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_COLOUR_LOGO-1536x575.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/VITIC_COLOUR_LOGO-2048x767.png 2048w" sizes="(max-width: 2463px) 100vw, 2463px"> </div> </div> <div class="elementor-element elementor-element-ca978ee elementor-widget elementor-widget-text-editor" data-id="ca978ee" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Vitic</strong> provides high-quality, peer-reviewed skin sensitisation data, which can support your individual safety assessments and read-across approaches.</p> </div> </div> </div> </div> <div data-dce-background-overlay-color="#FFFFFF" class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-5508551" data-id="5508551" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-5fdd7ef elementor-widget elementor-widget-heading" data-id="5fdd7ef" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Vitic highlights</h2> </div> </div> <div class="elementor-element elementor-element-27bd07e elementor-widget elementor-widget-text-editor" data-id="27bd07e" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;">Explore high-quality supporting data</span></strong><br />Access both <em>in vivo</em> skin sensitisation data and data from New Approach Methodologies (such as <em>in chemico </em>/<em>in vitro</em> assays etc.).</p> </div> </div> <div class="elementor-element elementor-element-3f100c0 elementor-widget elementor-widget-text-editor" data-id="3f100c0" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span style="color: #333f48;"><strong>Improve read-across assessments</strong><br /></span>With new data added on a regular basis, users of Vitic can access current skin sensitisation data to support predictions and read-across assessments.</p> </div> </div> <div class="elementor-element elementor-element-fc48dc2 elementor-widget elementor-widget-text-editor" data-id="fc48dc2" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span style="color: #333f48;"><strong>Access information derived from a range of sources</strong><br /></span>Contains expert curated, high-quality, peer-reviewed data from both published and unpublished sources.</p> </div> </div> <div class="elementor-element elementor-element-d3292e6 elementor-align-left elementor-widget elementor-widget-button" data-id="d3292e6" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> <div class="elementor-element elementor-element-2409846 elementor-widget elementor-widget-menu-anchor" data-id="2409846" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div class="elementor-menu-anchor" id="Skin-Sensitisation"></div> </div> </div> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-981014d" data-id="981014d" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <section data-dce-background-color="#FFFFFF" class="elementor-section elementor-top-section elementor-element elementor-element-2ff5a47 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="2ff5a47" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"background_background":"gradient"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-4b94bbd" data-id="4b94bbd" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-d8978b7" data-id="d8978b7" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-a2967e2 dce_masking-none elementor-widget elementor-widget-image" data-id="a2967e2" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="1351" height="511" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/SkinSens_Logo_Trans.png" class="attachment-full size-full wp-image-1579" alt="SkinSens Logo Trans" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/SkinSens_Logo_Trans.png 1351w, https://www.lhasalimited.org/wp-content/uploads/2022/11/SkinSens_Logo_Trans-300x113.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/SkinSens_Logo_Trans-1024x387.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/SkinSens_Logo_Trans-768x290.png 768w" sizes="(max-width: 1351px) 100vw, 1351px"> </div> </div> <div class="elementor-element elementor-element-b41e104 elementor-widget elementor-widget-text-editor" data-id="b41e104" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Skin Sensitisation Defined Approach ITSv1</strong> provides hazard and potency skin sensitisation predictions in place of using animal tests, which can assist your hazard characterisation and risk assessment.</p> </div> </div> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-32ff45c" data-id="32ff45c" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-a582edb elementor-widget elementor-widget-heading" data-id="a582edb" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Defined Approach ITSv1 highlights</h2> </div> </div> <div class="elementor-element elementor-element-6eade56 elementor-widget elementor-widget-text-editor" data-id="6eade56" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;">Use Derek as part of the ITSv1 defined approach</span></strong><br /><span style="font-weight: 400;">OECD Guideline No.497 recommends the use of a combination of non-animal methods to predict whether a chemical can cause skin allergies, known as a defined approach (DA). Quickly and efficiently predict hazard and potency categories by <a href="https://www.lhasalimited.org/replace-reduce-refine-how-lhasa-limited-are-supporting-the-3rs/">combining a Derek Nexus prediction with h-CLAT and DPRA data</a>.</span></p> </div> </div> <div class="elementor-element elementor-element-9ce6e0a elementor-widget elementor-widget-text-editor" data-id="9ce6e0a" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;">Generate accurate predictions quickly</span></strong><br />The defined approach has a high level of accuracy compared to animal and human data.</p> </div> </div> <div class="elementor-element elementor-element-c5b437a elementor-widget elementor-widget-text-editor" data-id="c5b437a" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;">Automate your Data Integration Procedure (DIP)</span></strong><br /><span style="font-weight: 400;">Our ITSv1 web application considers applicability domains, the handling of missing information sources and assessment of the prediction confidence.</span></p> </div> </div> <div class="elementor-element elementor-element-1268da0 elementor-align-left elementor-widget elementor-widget-button" data-id="1268da0" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-8ebf615" data-id="8ebf615" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-0133a05 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="0133a05" data-element_type="section" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-35909a2" data-id="35909a2" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-f64e7d6 elementor-widget elementor-widget-heading" data-id="f64e7d6" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Regulatory support</h2> </div> </div> <div class="elementor-element elementor-element-a2c152c elementor-widget elementor-widget-text-editor" data-id="a2c152c" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>The prediction of skin sensitisation is a key requirement for a number of chemical safety assessments and regulations:</p> </div> </div> <div class="elementor-element elementor-element-79158bb elementor-position-left elementor-view-default elementor-mobile-position-top elementor-vertical-align-top elementor-widget elementor-widget-icon-box" data-id="79158bb" data-element_type="widget" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" id="Layer_1" viewBox="0 0 408.85 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animal testing should be performed only as a last resort. Derek Nexus, Vitic and ITSv1 provide an alternative method to carrying out <i>in vivo</i> studies on animals. </p> </div> </div> </div> </div> <div class="elementor-element elementor-element-6978e56 elementor-position-left elementor-view-default elementor-mobile-position-top elementor-vertical-align-top elementor-widget elementor-widget-icon-box" data-id="6978e56" data-element_type="widget" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" id="Layer_1" viewBox="0 0 408.85 408.92"><defs><style>.cls-1{fill:url(#linear-gradient);}.cls-2{fill:url(#linear-gradient-3);}.cls-3{fill:url(#linear-gradient-4);}.cls-4{fill:url(#linear-gradient-2);}.cls-5{fill:url(#linear-gradient-6);}.cls-6{fill:url(#linear-gradient-5);}</style><linearGradient 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according to the CLP Regulation, displaying the correct hazard for skin corrosion/irritation. 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d="M203.94,120.63c15.7,0,31.4-.09,47.1,.04,9.09,.07,14.94,8.53,11.51,16.49-2.17,5.03-6.25,7.42-11.7,7.42-13.04,.01-26.08,0-39.12,0-18.36,0-36.72,.06-55.08-.03-9.39-.04-15.41-8.4-11.91-16.5,2.25-5.2,6.49-7.45,12.1-7.44,15.7,.04,31.4,.01,47.1,.01Z"></path><path class="cls-5" d="M300.27,333.02c7.91-8.36,14.75-15.78,21.8-23,5.94-6.09,11.98-12.1,18.19-17.9,7.21-6.74,17.75-3.92,20.24,5.25,1.19,4.38,0,8.28-3.11,11.37-16.24,16.1-32.5,32.19-48.93,48.09-4.94,4.79-11.44,4.66-16.53-.09-8.36-7.8-16.57-15.76-24.65-23.85-4.97-4.98-4.97-12.01-.42-16.85,4.5-4.79,11.53-5.04,16.85-.43,2.81,2.43,5.47,5.06,8.04,7.75,2.57,2.69,4.94,5.58,8.53,9.67Z"></path></svg> </span> </div> <div class="elementor-icon-box-content"> <h3 class="elementor-icon-box-title"> <span > OECD Guideline No. 497 </span> </h3> <p class="elementor-icon-box-description"> Defined Approaches on Skin Sensitisation can be used to meet other regulations such as REACH and CLP. The guideline recommends using defined approaches to predict whether a chemical can cause skin allergies. Our ITSv1 tool is a step towards full replacement of animal testing for skin sensitisation and employs the 3Rs principle - the replacement, reduction, and refinement of animals used for product testing and scientific research. </p> </div> </div> </div> </div> <div class="elementor-element elementor-element-9fd05c9 elementor-position-left elementor-view-default elementor-mobile-position-top elementor-vertical-align-top elementor-widget elementor-widget-icon-box" data-id="9fd05c9" data-element_type="widget" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" id="Layer_1" viewBox="0 0 408.85 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id="linear-gradient-4" x1="197.13" y1="-61.05" x2="213.1" y2="300.09" xlink:href="#linear-gradient"></linearGradient><linearGradient id="linear-gradient-5" x1="195.08" y1="-60.96" x2="211.05" y2="300.18" xlink:href="#linear-gradient"></linearGradient><linearGradient id="linear-gradient-6" x1="295.52" y1="-65.4" x2="311.48" y2="295.74" xlink:href="#linear-gradient"></linearGradient></defs><path class="cls-1" 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class="cls-4" d="M156.14,168.54c31.4,0,62.81-.03,94.21,.02,9.37,.01,15.35,7.7,12.43,15.86-1.74,4.86-5.36,7.45-10.43,8.01-1.32,.15-2.66,.07-3.99,.07-61.74,0-123.48,0-185.22,0-9.58,0-15.15-4.41-15.15-11.98,0-7.57,5.57-11.98,15.15-11.98,31,0,62.01,0,93.01,0Z"></path><path class="cls-2" d="M133.78,240.41c-24.34,0-48.67,.05-73.01-.03-9.21-.03-15.11-8.1-11.97-16.17,1.74-4.48,5.16-6.97,9.88-7.65,1.05-.15,2.12-.1,3.19-.1,48.14,0,96.28,0,144.42,0,6.84,0,11.48,2.92,13.19,8.19,2.58,7.97-3.11,15.66-11.88,15.73-15.03,.12-30.05,.03-45.08,.04-9.57,0-19.15,0-28.72,0Z"></path><path class="cls-3" d="M203.42,96.66c-15.7,0-31.4,.02-47.1,0-5.29,0-9.27-2.35-11.47-7.17-2-4.37-1.66-9,1.82-12.21,2.44-2.24,6.14-4.34,9.3-4.37,31.8-.32,63.6-.24,95.4-.15,6.91,.02,12.03,5.22,12.13,11.75,.1,6.69-5.1,12.05-12.18,12.1-15.97,.12-31.93,.04-47.9,.04Z"></path><path class="cls-6" d="M203.94,120.63c15.7,0,31.4-.09,47.1,.04,9.09,.07,14.94,8.53,11.51,16.49-2.17,5.03-6.25,7.42-11.7,7.42-13.04,.01-26.08,0-39.12,0-18.36,0-36.72,.06-55.08-.03-9.39-.04-15.41-8.4-11.91-16.5,2.25-5.2,6.49-7.45,12.1-7.44,15.7,.04,31.4,.01,47.1,.01Z"></path><path class="cls-5" d="M300.27,333.02c7.91-8.36,14.75-15.78,21.8-23,5.94-6.09,11.98-12.1,18.19-17.9,7.21-6.74,17.75-3.92,20.24,5.25,1.19,4.38,0,8.28-3.11,11.37-16.24,16.1-32.5,32.19-48.93,48.09-4.94,4.79-11.44,4.66-16.53-.09-8.36-7.8-16.57-15.76-24.65-23.85-4.97-4.98-4.97-12.01-.42-16.85,4.5-4.79,11.53-5.04,16.85-.43,2.81,2.43,5.47,5.06,8.04,7.75,2.57,2.69,4.94,5.58,8.53,9.67Z"></path></svg> </span> </div> <div class="elementor-icon-box-content"> <h3 class="elementor-icon-box-title"> <span > EU regulation 1223/2009 </span> </h3> <p class="elementor-icon-box-description"> EU regulation 1223/2009 prohibits the use of animal testing for cosmetic ingredients. The use of Derek Nexus as part of a Defined Approach can deliver predictions that have a high concordance with the LLNA assay and provides a significant step forward in assessing skin sensitisation. </p> </div> </div> </div> </div> <div class="elementor-element elementor-element-1d0385a elementor-position-left elementor-view-default elementor-mobile-position-top elementor-vertical-align-top elementor-widget elementor-widget-icon-box" data-id="1d0385a" data-element_type="widget" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" id="Layer_1" viewBox="0 0 408.85 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class="cls-4" d="M156.14,168.54c31.4,0,62.81-.03,94.21,.02,9.37,.01,15.35,7.7,12.43,15.86-1.74,4.86-5.36,7.45-10.43,8.01-1.32,.15-2.66,.07-3.99,.07-61.74,0-123.48,0-185.22,0-9.58,0-15.15-4.41-15.15-11.98,0-7.57,5.57-11.98,15.15-11.98,31,0,62.01,0,93.01,0Z"></path><path class="cls-2" d="M133.78,240.41c-24.34,0-48.67,.05-73.01-.03-9.21-.03-15.11-8.1-11.97-16.17,1.74-4.48,5.16-6.97,9.88-7.65,1.05-.15,2.12-.1,3.19-.1,48.14,0,96.28,0,144.42,0,6.84,0,11.48,2.92,13.19,8.19,2.58,7.97-3.11,15.66-11.88,15.73-15.03,.12-30.05,.03-45.08,.04-9.57,0-19.15,0-28.72,0Z"></path><path class="cls-3" d="M203.42,96.66c-15.7,0-31.4,.02-47.1,0-5.29,0-9.27-2.35-11.47-7.17-2-4.37-1.66-9,1.82-12.21,2.44-2.24,6.14-4.34,9.3-4.37,31.8-.32,63.6-.24,95.4-.15,6.91,.02,12.03,5.22,12.13,11.75,.1,6.69-5.1,12.05-12.18,12.1-15.97,.12-31.93,.04-47.9,.04Z"></path><path class="cls-6" d="M203.94,120.63c15.7,0,31.4-.09,47.1,.04,9.09,.07,14.94,8.53,11.51,16.49-2.17,5.03-6.25,7.42-11.7,7.42-13.04,.01-26.08,0-39.12,0-18.36,0-36.72,.06-55.08-.03-9.39-.04-15.41-8.4-11.91-16.5,2.25-5.2,6.49-7.45,12.1-7.44,15.7,.04,31.4,.01,47.1,.01Z"></path><path class="cls-5" d="M300.27,333.02c7.91-8.36,14.75-15.78,21.8-23,5.94-6.09,11.98-12.1,18.19-17.9,7.21-6.74,17.75-3.92,20.24,5.25,1.19,4.38,0,8.28-3.11,11.37-16.24,16.1-32.5,32.19-48.93,48.09-4.94,4.79-11.44,4.66-16.53-.09-8.36-7.8-16.57-15.76-24.65-23.85-4.97-4.98-4.97-12.01-.42-16.85,4.5-4.79,11.53-5.04,16.85-.43,2.81,2.43,5.47,5.06,8.04,7.75,2.57,2.69,4.94,5.58,8.53,9.67Z"></path></svg> </span> </div> <div class="elementor-icon-box-content"> <h3 class="elementor-icon-box-title"> <span > ICH Q3E </span> </h3> <p class="elementor-icon-box-description"> The upcoming ICH Q3E guideline will recognise the need to assess the sensitisation potential of extractable and leachable (E&L) compounds. 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