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class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Bertrand TOMBAL</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://uclep.academia.edu/">Universit茅 catholique de Louvain</a>, <a class="u-tcGrayDarker" href="https://uclep.academia.edu/Departments/Facult%C3%A9_de_M%C3%A9decine/Documents">Facult茅 de M茅decine</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Bertrand" data-follow-user-id="185020643" data-follow-user-source="profile_button" 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data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">15</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/BertrandTOMBAL/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://pgimer.academia.edu/AshokKumarYadav"><img class="profile-avatar u-positionAbsolute" alt="Ashok Kumar Yadav" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/2387781/749026/931655/s200_ashok_kumar.yadav.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://pgimer.academia.edu/AshokKumarYadav">Ashok Kumar Yadav</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">PGIMER,CHD,India</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://pucp.academia.edu/FernandoCasta%C3%B1edaPortocarrero"><img class="profile-avatar u-positionAbsolute" alt="Fernando Casta帽eda Portocarrero" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" 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PASCHOS, PH.D., ESQ.</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Aristotle University of Thessaloniki</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://zagazig.academia.edu/AymanAlkawas"><img class="profile-avatar u-positionAbsolute" alt="Ayman Alkawas" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/24055525/7068149/7965510/s200_ayman.alkawas.jpg_oh_107efa7e5f6a083913262a6b71e80835_oe_555ed186___gda___1431140638_7af7e31cb5a2e4628272a4a30383bde4" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://zagazig.academia.edu/AymanAlkawas">Ayman Alkawas</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Zagazig University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://oxford.academia.edu/ClarissaMoreira"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://oxford.academia.edu/ClarissaMoreira">Clarissa Moreira</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Oxford</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://muchs.academia.edu/BillyNgasala"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://muchs.academia.edu/BillyNgasala">Billy Ngasala</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Muhimbili University of Health and Allied Sciences (MUHAS)</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://ki.academia.edu/GabrielleFr%C3%B6berg"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://ki.academia.edu/GabrielleFr%C3%B6berg">Gabrielle Fr枚berg</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Karolinska Institutet</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://muchs.academia.edu/SaidAboud"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://muchs.academia.edu/SaidAboud">Said Aboud</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Muhimbili University of Health and Allied Sciences (MUHAS)</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://en-uoa-gr.academia.edu/CMarkopoulos"><img class="profile-avatar u-positionAbsolute" alt="C. Markopoulos" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/37735445/18220356/18198348/s200_c..markopoulos.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://en-uoa-gr.academia.edu/CMarkopoulos">C. Markopoulos</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">National and Kapodistrian University of Athens</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="185020643">View All (7)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="185020643" href="https://www.academia.edu/Documents/in/Imatinib"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://uclep.academia.edu/BertrandTOMBAL","location":"/BertrandTOMBAL","scheme":"https","host":"uclep.academia.edu","port":null,"pathname":"/BertrandTOMBAL","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div 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style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Procedures"]}" data-trace="false" data-dom-id="Pill-react-component-092c8d35-d912-4f4d-b993-e76c2790fbe0"></div> <div id="Pill-react-component-092c8d35-d912-4f4d-b993-e76c2790fbe0"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Bertrand TOMBAL</h3></div><div class="js-work-strip profile--work_container" data-work-id="45077469"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077469/608_Bone_marrow_magnetic_resonance_imaging_allows_objective_assessment_of_prostate_cancer_PCA_bone_metastases"><img alt="Research paper thumbnail of 608 Bone marrow magnetic resonance imaging allows objective assessment of prostate cancer (PCA) bone metastases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077469/608_Bone_marrow_magnetic_resonance_imaging_allows_objective_assessment_of_prostate_cancer_PCA_bone_metastases">608 Bone marrow magnetic resonance imaging allows objective assessment of prostate cancer (PCA) bone metastases</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077469"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077469"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077469; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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href="https://www.academia.edu/45077468/Prostate_Cancer_Unit_Initiative_in_Europe_a_position_paper_by_the_European_School_of_Oncology"><img alt="Research paper thumbnail of Prostate Cancer Unit Initiative in Europe: a position paper by the European School of Oncology" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077468/Prostate_Cancer_Unit_Initiative_in_Europe_a_position_paper_by_the_European_School_of_Oncology">Prostate Cancer Unit Initiative in Europe: a position paper by the European School of Oncology</a></div><div class="wp-workCard_item"><span>Critical Reviews in Oncology/Hematology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Prostate Cancer Programme of the European School of Oncology developed the concept of special...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Prostate Cancer Programme of the European School of Oncology developed the concept of specialised interdisciplinary and multiprofessional prostate cancer care to be formalized in Prostate Cancer Units (PCU). After the publication in 2011 of the collaborative article &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;The Requirements of a Specialist Prostate Cancer Unit: A Discussion Paper from the European School of Oncology&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;, in 2012 the PCU Initiative in Europe was launched. A multiprofessional Task Force of internationally recognized opinion leaders, among whom representatives of scientific societies, and patient advocates gathered to set standards for quality comprehensive prostate cancer care and designate care pathways in PCUs. The result was a consensus on 40 mandatory and recommended standards and items, covering several macro-areas, from general requirements to personnel to organization and case management. This position paper describes the relevant, feasible and applicable core criteria for defining PCUs in most European countries delivered by PCU Initiative in Europe Task Force.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077468"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077468"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077468; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077466"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077466/C176_Prolonged_Bone_Metastasis_Free_Survival_in_Men_with_Castrate_Resistant_Prostate_Cancer_Receiving_Denosumab_Results_from_a_Phase_3_Randomised_Double_Blind_Trial"><img alt="Research paper thumbnail of C176 Prolonged Bone Metastasis-Free Survival in Men with Castrate-Resistant Prostate Cancer Receiving Denosumab: Results from a Phase 3, Randomised, Double-Blind Trial" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077466/C176_Prolonged_Bone_Metastasis_Free_Survival_in_Men_with_Castrate_Resistant_Prostate_Cancer_Receiving_Denosumab_Results_from_a_Phase_3_Randomised_Double_Blind_Trial">C176 Prolonged Bone Metastasis-Free Survival in Men with Castrate-Resistant Prostate Cancer Receiving Denosumab: Results from a Phase 3, Randomised, Double-Blind Trial</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077466"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077466"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077466; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077465"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077465/907_the_Number_of_Positive_Section_Margins_in_High_Risk_Prostate_Cancer_is_a_Powerful_and_Independent_Predictor_of_Cancer_Specific_and_Overall_Survival_in_High_Risk_Localized_Prostate_Cancer"><img alt="Research paper thumbnail of 907 the Number of Positive Section Margins in High-Risk Prostate Cancer is a Powerful and Independent Predictor of Cancer-Specific and Overall Survival in High-Risk Localized Prostate Cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/65635286/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077465/907_the_Number_of_Positive_Section_Margins_in_High_Risk_Prostate_Cancer_is_a_Powerful_and_Independent_Predictor_of_Cancer_Specific_and_Overall_Survival_in_High_Risk_Localized_Prostate_Cancer">907 the Number of Positive Section Margins in High-Risk Prostate Cancer is a Powerful and Independent Predictor of Cancer-Specific and Overall Survival in High-Risk Localized Prostate Cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Eur Urol Suppl 2011;10(2):285 margins were 80% and 59%, respectively (HR 2.1; p<0.001). The prese...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Eur Urol Suppl 2011;10(2):285 margins were 80% and 59%, respectively (HR 2.1; p<0.001). The presence of positive surgical margins was related to biochemical failure in pT2 as well as in pT3a tumors (p=0.001 und p=0.015). 64% of solitary positive surgical margins were localized at the apex. Multifocality, localization, and extent of positive surgical margins did not reveal significant influence on prognosis. Conclusions: Even solitary apical and small positive surgical margins in prostatectomy specimens significantly reduce biochemical failure-free survival. Thus, potential consequences of positive surgical margins even in organ confined tumors should be discussed with patients, as over 30% will develop biochemical failure within seven years. Furthermore respective awareness should be implemented in follow-up strategies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bd503d92c70d4bbcb548ff9cb84d7e84" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635286,"asset_id":45077465,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635286/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077465"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077465"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077465; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077464"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077464/Prevention_and_early_detection_of_prostate_cancer"><img alt="Research paper thumbnail of Prevention and early detection of prostate cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/65635292/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077464/Prevention_and_early_detection_of_prostate_cancer">Prevention and early detection of prostate cancer</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://uclep.academia.edu/BertrandTOMBAL">Bertrand TOMBAL</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MangeshThorat6">Mangesh Thorat</a></span></div><div class="wp-workCard_item"><span>The Lancet Oncology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prostate cancer is one of the most common cancers in men and the global burden of this disease is...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prostate cancer is one of the most common cancers in men and the global burden of this disease is rising. Lifestyle modifications like smoking cessation, exercise and weight control offer opportunities to decrease the risk of developing prostate cancer. Early detection of prostate cancer by PSA screening remains controversial; yet, changes in PSA threshold, frequency of screening, and addition of other biomarkers have potential to minimise overdiagnosis associated with PSA screening. Several new biomarkers appear promising in individuals with elevated PSA levels or those diagnosed with prostate cancer, these are likely to guide in separating individuals who can be spared of aggressive treatment from those who need it. Several pharmacological agents like 5伪-reductase inhibitors, aspirin etc. have a potential to prevent development of prostate cancer. In this review, we discuss the current evidence and research questions regarding prevention, early detection of prostate cancer and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1f49bad476d144e37b0d486edc2bd7cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635292,"asset_id":45077464,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635292/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077464"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077464"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077464; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077463"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077463/515_Definition_of_Continence_After_Radical_Prostatectomy_RP_Should_Patient_Reporting_Occasional_Leak_or_Pad_Wearing_Be_Considered_Continent"><img alt="Research paper thumbnail of 515 Definition of Continence After Radical Prostatectomy (RP): Should Patient Reporting Occasional Leak or Pad Wearing Be Considered Continent?" class="work-thumbnail" src="https://attachments.academia-assets.com/65635287/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077463/515_Definition_of_Continence_After_Radical_Prostatectomy_RP_Should_Patient_Reporting_Occasional_Leak_or_Pad_Wearing_Be_Considered_Continent">515 Definition of Continence After Radical Prostatectomy (RP): Should Patient Reporting Occasional Leak or Pad Wearing Be Considered Continent?</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="be5e5365ce3bb84d5510e474acfa37ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635287,"asset_id":45077463,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635287/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077463"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077463"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077463; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077462"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077462/Expression_of_prostate_specific_antigen_and_prostate_specific_membrane_antigen_transcripts_in_blood_cells_implications_for_the_detection_of_hematogenous_prostate_cells_and_standardization"><img alt="Research paper thumbnail of Expression of prostate-specific antigen and prostate-specific membrane antigen transcripts in blood cells: implications for the detection of hematogenous prostate cells and standardization" class="work-thumbnail" src="https://attachments.academia-assets.com/65635262/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077462/Expression_of_prostate_specific_antigen_and_prostate_specific_membrane_antigen_transcripts_in_blood_cells_implications_for_the_detection_of_hematogenous_prostate_cells_and_standardization">Expression of prostate-specific antigen and prostate-specific membrane antigen transcripts in blood cells: implications for the detection of hematogenous prostate cells and standardization</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Circulating prostate cells can be detected in cancer patients by using reverse transcriptase-PCR ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Circulating prostate cells can be detected in cancer patients by using reverse transcriptase-PCR (RT-PCR) assay for prostate-specific antigen (PSA) and prostate- specific membrane antigen (PSM) mRNA. A quality- control study involving a conventional RT-PCR assay was performed and, surprisingly, detected both tran- scripts in many negative control cell lines and in normal blood samples. The existence of an illegitimate tran-</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6cbc201a411ba3d484603333d5befac8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635262,"asset_id":45077462,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635262/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077462"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077462"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077462; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="33219244"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/33219244/1046_Three_or_More_Positive_Nodes_at_Radical_Prostatectomy_Represent_a_Significant_Cut_Off_Value_for_CSS_in_High_Risk_Prostate_Cancer_While_1_or_2_Positive_Nodes_Do_Not_Influence_CSS"><img alt="Research paper thumbnail of 1046 Three or More Positive Nodes at Radical Prostatectomy Represent a Significant Cut-Off Value for CSS in High-Risk Prostate Cancer, While 1 or 2 Positive Nodes Do Not Influence CSS" class="work-thumbnail" src="https://attachments.academia-assets.com/53296858/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/33219244/1046_Three_or_More_Positive_Nodes_at_Radical_Prostatectomy_Represent_a_Significant_Cut_Off_Value_for_CSS_in_High_Risk_Prostate_Cancer_While_1_or_2_Positive_Nodes_Do_Not_Influence_CSS">1046 Three or More Positive Nodes at Radical Prostatectomy Represent a Significant Cut-Off Value for CSS in High-Risk Prostate Cancer, While 1 or 2 Positive Nodes Do Not Influence CSS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/BrunoFrea">Bruno Frea</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://uclep.academia.edu/BertrandTOMBAL">Bertrand TOMBAL</a></span></div><div class="wp-workCard_item"><span>European Urology Supplements - EUR UROL SUPPL</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f50792d4d5784a4948b77a0d4384fbc9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53296858,"asset_id":33219244,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53296858/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="33219244"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="33219244"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33219244; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077461"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077461/563_in_High_Risk_Prostate_Cancer_the_Number_of_Lymph_Nodes_Removed_at_Radical_Prostatectomy_Does_Not_Affect_the_Risk_of_Cancer_Related_Death_or_Death_from_Any_Cause"><img alt="Research paper thumbnail of 563 in High-Risk Prostate Cancer, the Number of Lymph Nodes Removed at Radical Prostatectomy Does Not Affect the Risk of Cancer Related Death or Death from Any Cause" class="work-thumbnail" src="https://attachments.academia-assets.com/65635284/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077461/563_in_High_Risk_Prostate_Cancer_the_Number_of_Lymph_Nodes_Removed_at_Radical_Prostatectomy_Does_Not_Affect_the_Risk_of_Cancer_Related_Death_or_Death_from_Any_Cause">563 in High-Risk Prostate Cancer, the Number of Lymph Nodes Removed at Radical Prostatectomy Does Not Affect the Risk of Cancer Related Death or Death from Any Cause</a></div><div class="wp-workCard_item"><span>European Urology Supplements - EUR UROL SUPPL</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Eur Urol Suppl 2011;10(2):185 of PLND, patients were divided as follows: Group 1 = 61 (8.4%) , Gr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Eur Urol Suppl 2011;10(2):185 of PLND, patients were divided as follows: Group 1 = 61 (8.4%) , Group 2 = 431 (59.7%) and Group 3 = 230 (31.9%) patients. Mean number of nodes removed in patients receiving PLND was 16.8 (median 16;. No significant differences in the rates of EF recovery was recorded among the 3 groups (52% vs. 38% vs. 38% at 1 and 63% vs. 52% vs. 46% at 2-years after BNSRP, respectively; p=0.09). These data were confirmed at multivariable Cox regression analyses where PLND extent was not associated with EF recovery (p=0.2), after accounting for patient age, PSA, clinical stage, biopsy Gleason sum and pre-operative EF. Conversely, a significant association between pre-operative EF and age at surgery was found at multivariable analysis (all p<0.001). Conclusions: This is the first study addressing the association between PLND and EF recovery after BNSRP. We demonstrated that the extent of PLND does not affect the rate of EF recovery after BNSRP. Age and pre-operative EF remain the strongest predictors of EF recovery in patients treated with BNSRP for clinically localized PCa.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="60ed7e8eb83ed0e7e228c5e90b4d5cb0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635284,"asset_id":45077461,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635284/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077461"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077461"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077461; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077460"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077460/Intermittent_endocrine_treatment"><img alt="Research paper thumbnail of Intermittent endocrine treatment" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077460/Intermittent_endocrine_treatment">Intermittent endocrine treatment</a></div><div class="wp-workCard_item"><span>World Journal of Urology</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intermittent endocrine treatment or cyclic therapy of prostate cancer aims at prolonging survival...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intermittent endocrine treatment or cyclic therapy of prostate cancer aims at prolonging survival by delaying progression to androgen independence and at improving quality of life by avoiding the side effects of continuous androgen ablation. In this paper we first review the available experimental data suggesting the clinical application of this therapeutic strategy and interpret them with caution. We then examine the published reports of phase II clinical studies showing the feasibility of this approach. Intermittent endocrine treatment is capable of inducing multiple apoptotic regressions; improvement in the sense of well-being and quality of life - including sexual function - is regularly reported. A period of 6-9 months on therapy is usually recommended; the mean off-therapy interval approaches 50% of the duration of the treatment cycle. The mean time to disease progression was 32 months. The definitive answer to the important question of prolonged survival awaits the completion of ongoing randomized studies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077460"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077460"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077460; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45077460]").text(description); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077458"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077458/POD_02_07_Development_of_a_Risk_Based_Decision_Model_for_Prostate_CAncer_Gene_3_PCA3_Usage"><img alt="Research paper thumbnail of POD-02.07 Development of a Risk-Based Decision Model for Prostate CAncer Gene 3 (PCA3) Usage" class="work-thumbnail" src="https://attachments.academia-assets.com/65635282/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077458/POD_02_07_Development_of_a_Risk_Based_Decision_Model_for_Prostate_CAncer_Gene_3_PCA3_Usage">POD-02.07 Development of a Risk-Based Decision Model for Prostate CAncer Gene 3 (PCA3) Usage</a></div><div class="wp-workCard_item"><span>Urology</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">cases. Meanwhile proportion of metastatic cancers of 10% stays unaltered for the last 10 years. A...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">cases. Meanwhile proportion of metastatic cancers of 10% stays unaltered for the last 10 years. Among RP patients, proportion stabilized for the last 15 years and presented very slow down rate of locally advanced PCa incidence, while radical radiotherapy candidates increases continuously.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="51f618336119e856d75f35afa7db55df" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635282,"asset_id":45077458,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635282/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077458"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077458"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077458; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45077458]").text(description); $(".js-view-count[data-work-id=45077458]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45077458; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='45077458']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077457"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077457/Free_total_PSA_ratio_does_not_improve_prediction_of_pathologic_stage_and_biochemical_recurrence_after_radical_prostatectomy"><img alt="Research paper thumbnail of Free/total PSA ratio does not improve prediction of pathologic stage and biochemical recurrence after radical prostatectomy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077457/Free_total_PSA_ratio_does_not_improve_prediction_of_pathologic_stage_and_biochemical_recurrence_after_radical_prostatectomy">Free/total PSA ratio does not improve prediction of pathologic stage and biochemical recurrence after radical prostatectomy</a></div><div class="wp-workCard_item"><span>Urology</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite several publications, the ability of the free/total (F/T) prostate-specific antigen (PSA)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite several publications, the ability of the free/total (F/T) prostate-specific antigen (PSA) ratio to predict the pathologic extension of prostate cancer is still a matter of controversy. In addition, its ability to predict biochemical recurrence after radical prostatectomy has not yet been reported. Since January 6, 1996, the F/T PSA ratio was prospectively measured preoperatively in 343 patients undergoing radical prostatectomy as the first treatment for localized prostate cancer. The ability to predict organ-confined disease was measured by receiver operating characteristic analysis. The areas under the curve were 0.66 for PSA density, 0.61 for total PSA, 0.60 for Gleason score, and 0.587 for the F/T PSA ratio. In multiple logistic regression analyses, the F/T PSA ratio was not a relevant predictor of organ-confined disease (Wald statistic 0.345 for P = 0.55). Similar results were obtained in the subgroup of patients with a PSA level between 2.5 and 10 ng/mL. The biochemical survival for the 270 patients who did not receive adjuvant therapy was 86% at 61 months. Statistically significant univariate predictors (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05) of PSA recurrence were pT stage (log-rank 18.2) and Gleason grade (log-rank 8.8). The F/T PSA ratio was not a significant predictor of recurrence in the univariate analysis (log-rank 3.6 for P = 0.314) and in multivariate analysis (Wald statistic 0.2 for P = 0.97). These results suggest that the F/T PSA ratio is not helpful for the prediction of organ-confined disease and PSA recurrence after radical prostatectomy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077457"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077457"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077457; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45077457]").text(description); $(".js-view-count[data-work-id=45077457]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45077457; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='45077457']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="45077456"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077456/Free_to_total_prostate_specific_antigen_PSA_ratio_is_superior_to_total_PSA_in_differentiating_benign_prostate_hypertrophy_from_prostate_cancer"><img alt="Research paper thumbnail of Free to total prostate鈥恠pecific antigen (PSA) ratio is superior to total鈥怭SA in differentiating benign prostate hypertrophy from prostate cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077456/Free_to_total_prostate_specific_antigen_PSA_ratio_is_superior_to_total_PSA_in_differentiating_benign_prostate_hypertrophy_from_prostate_cancer">Free to total prostate鈥恠pecific antigen (PSA) ratio is superior to total鈥怭SA in differentiating benign prostate hypertrophy from prostate cancer</a></div><div class="wp-workCard_item"><span>The Prostate</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Serum prostate-specific antigen (PSA) exists in different molecular forms, and their respective c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Serum prostate-specific antigen (PSA) exists in different molecular forms, and their respective concentration has been proposed as a useful tool to improve discrimination between benign prostatic hypertrophy (BPH) and prostate cancer (PC). The relevance of the free to total PSA ratio was prospectively studied in a selected urology clinic population of 420 patients. Total serum PSA ranged from 2.1 to 30 ng/ml; 154 had PC and 266 had BPH. Receiver operating characteristic (ROC) curves were constructed for the total population (total-PSA range from 2.1 to 30 ng/ml) and for the diagnostic gray zone of 2.1-10 ng/ml. For the two groups, the free to total PSA ratio had a higher specificity than total-PSA for all sensitivity levels. Cut-off values were found to, vary with prostate weight. Although free to total PSA ratio demonstrated better performances than total-PSA, its use in screening appears problematic, due to the low prevalence of prostate cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077456"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077456"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077456; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45077456]").text(description); $(".js-view-count[data-work-id=45077456]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45077456; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='45077456']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=45077456]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":45077456,"title":"Free to total prostate鈥恠pecific antigen (PSA) ratio is superior to total鈥怭SA in differentiating benign prostate hypertrophy from prostate cancer","internal_url":"https://www.academia.edu/45077456/Free_to_total_prostate_specific_antigen_PSA_ratio_is_superior_to_total_PSA_in_differentiating_benign_prostate_hypertrophy_from_prostate_cancer","owner_id":185020643,"coauthors_can_edit":true,"owner":{"id":185020643,"first_name":"Bertrand","middle_initials":null,"last_name":"TOMBAL","page_name":"BertrandTOMBAL","domain_name":"uclep","created_at":"2021-02-08T04:37:44.256-08:00","display_name":"Bertrand TOMBAL","url":"https://uclep.academia.edu/BertrandTOMBAL"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077455"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077455/Magnetic_resonance_imaging_of_the_axial_skeleton_enables_objective_measurement_of_tumor_response_on_prostate_cancer_bone_metastases"><img alt="Research paper thumbnail of Magnetic resonance imaging of the axial skeleton enables objective measurement of tumor response on prostate cancer bone metastases" class="work-thumbnail" src="https://attachments.academia-assets.com/65635293/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077455/Magnetic_resonance_imaging_of_the_axial_skeleton_enables_objective_measurement_of_tumor_response_on_prostate_cancer_bone_metastases">Magnetic resonance imaging of the axial skeleton enables objective measurement of tumor response on prostate cancer bone metastases</a></div><div class="wp-workCard_item"><span>The Prostate</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND. There is currently no technique to image quantitatively bone metastases. Here, we ass...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND. There is currently no technique to image quantitatively bone metastases. Here, we assessed the value of MRI of the axial skeleton (AS-MRI) as a single step technique to quantify bone metastases and measure tumor response. METHODS. AS-MRI was performed in 38 patients before receiving chemotherapy for metastatic HRPCa, in addition to PSA, computed tomography of the thorax, abdomen, and pelvis [CT-TAP]; and Tc-99m bone scintigraphy. A second AS-MRI was performed in 20 patients who completed 6 months of chemotherapy. Evaluation of tumor response was performed using RECIST. RESULTS. Only 11 patients (29%) had RECIST measurable metastases in soft-tissues or lymph nodes on baseline CT-TAP. AS-MRI identified a diffuse infiltration of the bone marrow in 8 patients and focal measurable metastatic lesions in 25 patients (65%), therefore, doubling the proportion of patients with measurable lesions. Transposing RECIST on AS-MRI in 20 patients who completed 6 months of treatment, allows the accurate estimation of complete response (n 录 2), partial response (n 录 2), stable disease (n 录 5), or tumor progression (n 录 11), as it is done using CT-TAP in soft tissue solid metastases. CONCLUSIONS. MRI of axial skeleton enables precise measurement and follow-up of bone metastases as it is for other soft-tissue metastasis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ec4c3e4a3a13f01f7b08a69a75a27974" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635293,"asset_id":45077455,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635293/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077455"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077455"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077455; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077454"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077454/Prognostic_value_of_circulating_prostate_cells_in_patients_with_a_rising_PSA_after_radical_prostatectomy"><img alt="Research paper thumbnail of Prognostic value of circulating prostate cells in patients with a rising PSA after radical prostatectomy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077454/Prognostic_value_of_circulating_prostate_cells_in_patients_with_a_rising_PSA_after_radical_prostatectomy">Prognostic value of circulating prostate cells in patients with a rising PSA after radical prostatectomy</a></div><div class="wp-workCard_item"><span>The Prostate</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To predict poor outcome in patients with a biochemical recurrence (rising PSA) after radical pros...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To predict poor outcome in patients with a biochemical recurrence (rising PSA) after radical prostatectomy (RP), urologists rely primarily on Gleason score, PSA doubling time, and time from surgery to biochemical (i.e., PSA) recurrence. In the present study, we assess the value of RT-PCR detection circulating prostate cells in blood of patients with a rising PSA. RNA from blood samples was obtained from 55 patients with a rising PSA and from 45 patients without evidence of biochemical failure (PSA &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.1 ng/ml). Both groups were matched for age, Gleason score, pT stage, and interval between radical prostatectomy and PCR testing. PSA positive cells were detected in 1/45 (2%) patients without a PSA recurrence and 19/55 (34%) patients with a PSA recurrence. In the rising PSA group, mean PSA doubling time was significantly shorter in patients with positive RT-PCR (5 months) than in patients with negative RT-PCR (16 months; P = 0.001). An earlier onset of recurrence was also detected in patients with a positive RT-PCR (31 months for positive RT-PCR vs. 50 months for negative RT-PCR) but this result did not achieve statistical significance (P = 0.102). Salvage radiation therapy was administered in 15 patients. Three of the five patients with a positive RT-PCR progressed during radiotherapy whereas 7 of the 10 patients with a negative RT-PCR obtained a complete response and none have progressed. These preliminary results suggest that RT-PCR detection of prostate cells in blood of patients after RP correlates with rapidly progressing biochemical failure after RP.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077454"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077454"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077454; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="33219315"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/33219315/294_in_High_Risk_Prostate_Cancer_3_or_More_Positive_Nodes_at_Radical_Prostatectomy_Represent_an_Independent_Predictor_of_Worse_CSS_While_1_or_2_Positive_Nodes_Do_Not_Influence_CSS"><img alt="Research paper thumbnail of 294 in High-Risk Prostate Cancer, 3 or More Positive Nodes at Radical Prostatectomy Represent an Independent Predictor of Worse CSS, While 1 or 2 Positive Nodes Do Not Influence CSS" class="work-thumbnail" src="https://attachments.academia-assets.com/53296886/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/33219315/294_in_High_Risk_Prostate_Cancer_3_or_More_Positive_Nodes_at_Radical_Prostatectomy_Represent_an_Independent_Predictor_of_Worse_CSS_While_1_or_2_Positive_Nodes_Do_Not_Influence_CSS">294 in High-Risk Prostate Cancer, 3 or More Positive Nodes at Radical Prostatectomy Represent an Independent Predictor of Worse CSS, While 1 or 2 Positive Nodes Do Not Influence CSS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/BrunoFrea">Bruno Frea</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://uclep.academia.edu/BertrandTOMBAL">Bertrand TOMBAL</a></span></div><div class="wp-workCard_item"><span>J Urol</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">INTRODUCTION AND OBJECTIVES: The finding of nodal metastases (N烯) at the time of radical prostate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">INTRODUCTION AND OBJECTIVES: The finding of nodal metastases (N烯) at the time of radical prostatectomy (RP) and pelvic</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e66872007165d10ef8adca79cb4f850" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53296886,"asset_id":33219315,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53296886/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="33219315"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="33219315"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33219315; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077452"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077452/The_application_of_adjuvant_autologous_antravesical_macrophage_cell_therapy_vs_BCG_in_non_muscle_invasive_bladder_cancer_a_multicenter_randomized_trial"><img alt="Research paper thumbnail of The application of adjuvant autologous antravesical macrophage cell therapy vs. BCG in non-muscle invasive bladder cancer: a multicenter, randomized trial" class="work-thumbnail" src="https://attachments.academia-assets.com/65635289/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077452/The_application_of_adjuvant_autologous_antravesical_macrophage_cell_therapy_vs_BCG_in_non_muscle_invasive_bladder_cancer_a_multicenter_randomized_trial">The application of adjuvant autologous antravesical macrophage cell therapy vs. BCG in non-muscle invasive bladder cancer: a multicenter, randomized trial</a></div><div class="wp-workCard_item"><span>Journal of Translational Medicine</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: While adjuvant immunotherapy with Bacille Calmette Gu茅rin (BCG) is effective in non...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: While adjuvant immunotherapy with Bacille Calmette Gu茅rin (BCG) is effective in non-muscle-invasive bladder cancer (BC), adverse events (AEs) are considerable. Monocyte-derived activated killer cells (MAK) are discussed as essential in antitumoural immunoresponse, but their application may imply risks. The present trial compared autologous intravesical macrophage cell therapy (BEXIDEM 庐 ) to BCG in patients after transurethral resection (TURB) of BC.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b9be4f6df71a112f8ec57b7adc19a5fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635289,"asset_id":45077452,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635289/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077452"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077452"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077452; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="10912124" id="papers"><div class="js-work-strip profile--work_container" data-work-id="45077469"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077469/608_Bone_marrow_magnetic_resonance_imaging_allows_objective_assessment_of_prostate_cancer_PCA_bone_metastases"><img alt="Research paper thumbnail of 608 Bone marrow magnetic resonance imaging allows objective assessment of prostate cancer (PCA) bone metastases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077469/608_Bone_marrow_magnetic_resonance_imaging_allows_objective_assessment_of_prostate_cancer_PCA_bone_metastases">608 Bone marrow magnetic resonance imaging allows objective assessment of prostate cancer (PCA) bone metastases</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077469"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077469"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077469; 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</script> <div class="js-work-strip profile--work_container" data-work-id="45077468"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077468/Prostate_Cancer_Unit_Initiative_in_Europe_a_position_paper_by_the_European_School_of_Oncology"><img alt="Research paper thumbnail of Prostate Cancer Unit Initiative in Europe: a position paper by the European School of Oncology" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077468/Prostate_Cancer_Unit_Initiative_in_Europe_a_position_paper_by_the_European_School_of_Oncology">Prostate Cancer Unit Initiative in Europe: a position paper by the European School of Oncology</a></div><div class="wp-workCard_item"><span>Critical Reviews in Oncology/Hematology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Prostate Cancer Programme of the European School of Oncology developed the concept of special...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Prostate Cancer Programme of the European School of Oncology developed the concept of specialised interdisciplinary and multiprofessional prostate cancer care to be formalized in Prostate Cancer Units (PCU). After the publication in 2011 of the collaborative article &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;The Requirements of a Specialist Prostate Cancer Unit: A Discussion Paper from the European School of Oncology&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;, in 2012 the PCU Initiative in Europe was launched. A multiprofessional Task Force of internationally recognized opinion leaders, among whom representatives of scientific societies, and patient advocates gathered to set standards for quality comprehensive prostate cancer care and designate care pathways in PCUs. The result was a consensus on 40 mandatory and recommended standards and items, covering several macro-areas, from general requirements to personnel to organization and case management. This position paper describes the relevant, feasible and applicable core criteria for defining PCUs in most European countries delivered by PCU Initiative in Europe Task Force.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077468"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077468"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077468; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077466"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077466/C176_Prolonged_Bone_Metastasis_Free_Survival_in_Men_with_Castrate_Resistant_Prostate_Cancer_Receiving_Denosumab_Results_from_a_Phase_3_Randomised_Double_Blind_Trial"><img alt="Research paper thumbnail of C176 Prolonged Bone Metastasis-Free Survival in Men with Castrate-Resistant Prostate Cancer Receiving Denosumab: Results from a Phase 3, Randomised, Double-Blind Trial" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077466/C176_Prolonged_Bone_Metastasis_Free_Survival_in_Men_with_Castrate_Resistant_Prostate_Cancer_Receiving_Denosumab_Results_from_a_Phase_3_Randomised_Double_Blind_Trial">C176 Prolonged Bone Metastasis-Free Survival in Men with Castrate-Resistant Prostate Cancer Receiving Denosumab: Results from a Phase 3, Randomised, Double-Blind Trial</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077466"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077466"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077466; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077465"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077465/907_the_Number_of_Positive_Section_Margins_in_High_Risk_Prostate_Cancer_is_a_Powerful_and_Independent_Predictor_of_Cancer_Specific_and_Overall_Survival_in_High_Risk_Localized_Prostate_Cancer"><img alt="Research paper thumbnail of 907 the Number of Positive Section Margins in High-Risk Prostate Cancer is a Powerful and Independent Predictor of Cancer-Specific and Overall Survival in High-Risk Localized Prostate Cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/65635286/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077465/907_the_Number_of_Positive_Section_Margins_in_High_Risk_Prostate_Cancer_is_a_Powerful_and_Independent_Predictor_of_Cancer_Specific_and_Overall_Survival_in_High_Risk_Localized_Prostate_Cancer">907 the Number of Positive Section Margins in High-Risk Prostate Cancer is a Powerful and Independent Predictor of Cancer-Specific and Overall Survival in High-Risk Localized Prostate Cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Eur Urol Suppl 2011;10(2):285 margins were 80% and 59%, respectively (HR 2.1; p<0.001). The prese...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Eur Urol Suppl 2011;10(2):285 margins were 80% and 59%, respectively (HR 2.1; p<0.001). The presence of positive surgical margins was related to biochemical failure in pT2 as well as in pT3a tumors (p=0.001 und p=0.015). 64% of solitary positive surgical margins were localized at the apex. Multifocality, localization, and extent of positive surgical margins did not reveal significant influence on prognosis. Conclusions: Even solitary apical and small positive surgical margins in prostatectomy specimens significantly reduce biochemical failure-free survival. Thus, potential consequences of positive surgical margins even in organ confined tumors should be discussed with patients, as over 30% will develop biochemical failure within seven years. Furthermore respective awareness should be implemented in follow-up strategies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bd503d92c70d4bbcb548ff9cb84d7e84" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635286,"asset_id":45077465,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635286/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077465"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077465"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077465; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077464"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077464/Prevention_and_early_detection_of_prostate_cancer"><img alt="Research paper thumbnail of Prevention and early detection of prostate cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/65635292/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077464/Prevention_and_early_detection_of_prostate_cancer">Prevention and early detection of prostate cancer</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://uclep.academia.edu/BertrandTOMBAL">Bertrand TOMBAL</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MangeshThorat6">Mangesh Thorat</a></span></div><div class="wp-workCard_item"><span>The Lancet Oncology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prostate cancer is one of the most common cancers in men and the global burden of this disease is...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prostate cancer is one of the most common cancers in men and the global burden of this disease is rising. Lifestyle modifications like smoking cessation, exercise and weight control offer opportunities to decrease the risk of developing prostate cancer. Early detection of prostate cancer by PSA screening remains controversial; yet, changes in PSA threshold, frequency of screening, and addition of other biomarkers have potential to minimise overdiagnosis associated with PSA screening. Several new biomarkers appear promising in individuals with elevated PSA levels or those diagnosed with prostate cancer, these are likely to guide in separating individuals who can be spared of aggressive treatment from those who need it. Several pharmacological agents like 5伪-reductase inhibitors, aspirin etc. have a potential to prevent development of prostate cancer. In this review, we discuss the current evidence and research questions regarding prevention, early detection of prostate cancer and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1f49bad476d144e37b0d486edc2bd7cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635292,"asset_id":45077464,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635292/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077464"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077464"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077464; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077463"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077463/515_Definition_of_Continence_After_Radical_Prostatectomy_RP_Should_Patient_Reporting_Occasional_Leak_or_Pad_Wearing_Be_Considered_Continent"><img alt="Research paper thumbnail of 515 Definition of Continence After Radical Prostatectomy (RP): Should Patient Reporting Occasional Leak or Pad Wearing Be Considered Continent?" class="work-thumbnail" src="https://attachments.academia-assets.com/65635287/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077463/515_Definition_of_Continence_After_Radical_Prostatectomy_RP_Should_Patient_Reporting_Occasional_Leak_or_Pad_Wearing_Be_Considered_Continent">515 Definition of Continence After Radical Prostatectomy (RP): Should Patient Reporting Occasional Leak or Pad Wearing Be Considered Continent?</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="be5e5365ce3bb84d5510e474acfa37ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635287,"asset_id":45077463,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635287/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077463"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077463"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077463; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077462"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077462/Expression_of_prostate_specific_antigen_and_prostate_specific_membrane_antigen_transcripts_in_blood_cells_implications_for_the_detection_of_hematogenous_prostate_cells_and_standardization"><img alt="Research paper thumbnail of Expression of prostate-specific antigen and prostate-specific membrane antigen transcripts in blood cells: implications for the detection of hematogenous prostate cells and standardization" class="work-thumbnail" src="https://attachments.academia-assets.com/65635262/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077462/Expression_of_prostate_specific_antigen_and_prostate_specific_membrane_antigen_transcripts_in_blood_cells_implications_for_the_detection_of_hematogenous_prostate_cells_and_standardization">Expression of prostate-specific antigen and prostate-specific membrane antigen transcripts in blood cells: implications for the detection of hematogenous prostate cells and standardization</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Circulating prostate cells can be detected in cancer patients by using reverse transcriptase-PCR ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Circulating prostate cells can be detected in cancer patients by using reverse transcriptase-PCR (RT-PCR) assay for prostate-specific antigen (PSA) and prostate- specific membrane antigen (PSM) mRNA. A quality- control study involving a conventional RT-PCR assay was performed and, surprisingly, detected both tran- scripts in many negative control cell lines and in normal blood samples. The existence of an illegitimate tran-</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6cbc201a411ba3d484603333d5befac8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635262,"asset_id":45077462,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635262/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077462"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077462"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077462; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="33219244"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/33219244/1046_Three_or_More_Positive_Nodes_at_Radical_Prostatectomy_Represent_a_Significant_Cut_Off_Value_for_CSS_in_High_Risk_Prostate_Cancer_While_1_or_2_Positive_Nodes_Do_Not_Influence_CSS"><img alt="Research paper thumbnail of 1046 Three or More Positive Nodes at Radical Prostatectomy Represent a Significant Cut-Off Value for CSS in High-Risk Prostate Cancer, While 1 or 2 Positive Nodes Do Not Influence CSS" class="work-thumbnail" src="https://attachments.academia-assets.com/53296858/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/33219244/1046_Three_or_More_Positive_Nodes_at_Radical_Prostatectomy_Represent_a_Significant_Cut_Off_Value_for_CSS_in_High_Risk_Prostate_Cancer_While_1_or_2_Positive_Nodes_Do_Not_Influence_CSS">1046 Three or More Positive Nodes at Radical Prostatectomy Represent a Significant Cut-Off Value for CSS in High-Risk Prostate Cancer, While 1 or 2 Positive Nodes Do Not Influence CSS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/BrunoFrea">Bruno Frea</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://uclep.academia.edu/BertrandTOMBAL">Bertrand TOMBAL</a></span></div><div class="wp-workCard_item"><span>European Urology Supplements - EUR UROL SUPPL</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f50792d4d5784a4948b77a0d4384fbc9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53296858,"asset_id":33219244,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53296858/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="33219244"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="33219244"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33219244; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077461"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077461/563_in_High_Risk_Prostate_Cancer_the_Number_of_Lymph_Nodes_Removed_at_Radical_Prostatectomy_Does_Not_Affect_the_Risk_of_Cancer_Related_Death_or_Death_from_Any_Cause"><img alt="Research paper thumbnail of 563 in High-Risk Prostate Cancer, the Number of Lymph Nodes Removed at Radical Prostatectomy Does Not Affect the Risk of Cancer Related Death or Death from Any Cause" class="work-thumbnail" src="https://attachments.academia-assets.com/65635284/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077461/563_in_High_Risk_Prostate_Cancer_the_Number_of_Lymph_Nodes_Removed_at_Radical_Prostatectomy_Does_Not_Affect_the_Risk_of_Cancer_Related_Death_or_Death_from_Any_Cause">563 in High-Risk Prostate Cancer, the Number of Lymph Nodes Removed at Radical Prostatectomy Does Not Affect the Risk of Cancer Related Death or Death from Any Cause</a></div><div class="wp-workCard_item"><span>European Urology Supplements - EUR UROL SUPPL</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Eur Urol Suppl 2011;10(2):185 of PLND, patients were divided as follows: Group 1 = 61 (8.4%) , Gr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Eur Urol Suppl 2011;10(2):185 of PLND, patients were divided as follows: Group 1 = 61 (8.4%) , Group 2 = 431 (59.7%) and Group 3 = 230 (31.9%) patients. Mean number of nodes removed in patients receiving PLND was 16.8 (median 16;. No significant differences in the rates of EF recovery was recorded among the 3 groups (52% vs. 38% vs. 38% at 1 and 63% vs. 52% vs. 46% at 2-years after BNSRP, respectively; p=0.09). These data were confirmed at multivariable Cox regression analyses where PLND extent was not associated with EF recovery (p=0.2), after accounting for patient age, PSA, clinical stage, biopsy Gleason sum and pre-operative EF. Conversely, a significant association between pre-operative EF and age at surgery was found at multivariable analysis (all p<0.001). Conclusions: This is the first study addressing the association between PLND and EF recovery after BNSRP. We demonstrated that the extent of PLND does not affect the rate of EF recovery after BNSRP. Age and pre-operative EF remain the strongest predictors of EF recovery in patients treated with BNSRP for clinically localized PCa.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="60ed7e8eb83ed0e7e228c5e90b4d5cb0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635284,"asset_id":45077461,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635284/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077461"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077461"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077461; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077460"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077460/Intermittent_endocrine_treatment"><img alt="Research paper thumbnail of Intermittent endocrine treatment" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077460/Intermittent_endocrine_treatment">Intermittent endocrine treatment</a></div><div class="wp-workCard_item"><span>World Journal of Urology</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intermittent endocrine treatment or cyclic therapy of prostate cancer aims at prolonging survival...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intermittent endocrine treatment or cyclic therapy of prostate cancer aims at prolonging survival by delaying progression to androgen independence and at improving quality of life by avoiding the side effects of continuous androgen ablation. In this paper we first review the available experimental data suggesting the clinical application of this therapeutic strategy and interpret them with caution. We then examine the published reports of phase II clinical studies showing the feasibility of this approach. Intermittent endocrine treatment is capable of inducing multiple apoptotic regressions; improvement in the sense of well-being and quality of life - including sexual function - is regularly reported. A period of 6-9 months on therapy is usually recommended; the mean off-therapy interval approaches 50% of the duration of the treatment cycle. The mean time to disease progression was 32 months. The definitive answer to the important question of prolonged survival awaits the completion of ongoing randomized studies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077460"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077460"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077460; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45077460]").text(description); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077458"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077458/POD_02_07_Development_of_a_Risk_Based_Decision_Model_for_Prostate_CAncer_Gene_3_PCA3_Usage"><img alt="Research paper thumbnail of POD-02.07 Development of a Risk-Based Decision Model for Prostate CAncer Gene 3 (PCA3) Usage" class="work-thumbnail" src="https://attachments.academia-assets.com/65635282/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077458/POD_02_07_Development_of_a_Risk_Based_Decision_Model_for_Prostate_CAncer_Gene_3_PCA3_Usage">POD-02.07 Development of a Risk-Based Decision Model for Prostate CAncer Gene 3 (PCA3) Usage</a></div><div class="wp-workCard_item"><span>Urology</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">cases. Meanwhile proportion of metastatic cancers of 10% stays unaltered for the last 10 years. A...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">cases. Meanwhile proportion of metastatic cancers of 10% stays unaltered for the last 10 years. Among RP patients, proportion stabilized for the last 15 years and presented very slow down rate of locally advanced PCa incidence, while radical radiotherapy candidates increases continuously.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="51f618336119e856d75f35afa7db55df" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635282,"asset_id":45077458,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635282/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077458"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077458"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077458; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45077458]").text(description); $(".js-view-count[data-work-id=45077458]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45077458; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='45077458']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077457"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077457/Free_total_PSA_ratio_does_not_improve_prediction_of_pathologic_stage_and_biochemical_recurrence_after_radical_prostatectomy"><img alt="Research paper thumbnail of Free/total PSA ratio does not improve prediction of pathologic stage and biochemical recurrence after radical prostatectomy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077457/Free_total_PSA_ratio_does_not_improve_prediction_of_pathologic_stage_and_biochemical_recurrence_after_radical_prostatectomy">Free/total PSA ratio does not improve prediction of pathologic stage and biochemical recurrence after radical prostatectomy</a></div><div class="wp-workCard_item"><span>Urology</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite several publications, the ability of the free/total (F/T) prostate-specific antigen (PSA)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite several publications, the ability of the free/total (F/T) prostate-specific antigen (PSA) ratio to predict the pathologic extension of prostate cancer is still a matter of controversy. In addition, its ability to predict biochemical recurrence after radical prostatectomy has not yet been reported. Since January 6, 1996, the F/T PSA ratio was prospectively measured preoperatively in 343 patients undergoing radical prostatectomy as the first treatment for localized prostate cancer. The ability to predict organ-confined disease was measured by receiver operating characteristic analysis. The areas under the curve were 0.66 for PSA density, 0.61 for total PSA, 0.60 for Gleason score, and 0.587 for the F/T PSA ratio. In multiple logistic regression analyses, the F/T PSA ratio was not a relevant predictor of organ-confined disease (Wald statistic 0.345 for P = 0.55). Similar results were obtained in the subgroup of patients with a PSA level between 2.5 and 10 ng/mL. The biochemical survival for the 270 patients who did not receive adjuvant therapy was 86% at 61 months. Statistically significant univariate predictors (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05) of PSA recurrence were pT stage (log-rank 18.2) and Gleason grade (log-rank 8.8). The F/T PSA ratio was not a significant predictor of recurrence in the univariate analysis (log-rank 3.6 for P = 0.314) and in multivariate analysis (Wald statistic 0.2 for P = 0.97). These results suggest that the F/T PSA ratio is not helpful for the prediction of organ-confined disease and PSA recurrence after radical prostatectomy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077457"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077457"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077457; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45077457]").text(description); $(".js-view-count[data-work-id=45077457]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45077457; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='45077457']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="45077456"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077456/Free_to_total_prostate_specific_antigen_PSA_ratio_is_superior_to_total_PSA_in_differentiating_benign_prostate_hypertrophy_from_prostate_cancer"><img alt="Research paper thumbnail of Free to total prostate鈥恠pecific antigen (PSA) ratio is superior to total鈥怭SA in differentiating benign prostate hypertrophy from prostate cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077456/Free_to_total_prostate_specific_antigen_PSA_ratio_is_superior_to_total_PSA_in_differentiating_benign_prostate_hypertrophy_from_prostate_cancer">Free to total prostate鈥恠pecific antigen (PSA) ratio is superior to total鈥怭SA in differentiating benign prostate hypertrophy from prostate cancer</a></div><div class="wp-workCard_item"><span>The Prostate</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Serum prostate-specific antigen (PSA) exists in different molecular forms, and their respective c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Serum prostate-specific antigen (PSA) exists in different molecular forms, and their respective concentration has been proposed as a useful tool to improve discrimination between benign prostatic hypertrophy (BPH) and prostate cancer (PC). The relevance of the free to total PSA ratio was prospectively studied in a selected urology clinic population of 420 patients. Total serum PSA ranged from 2.1 to 30 ng/ml; 154 had PC and 266 had BPH. Receiver operating characteristic (ROC) curves were constructed for the total population (total-PSA range from 2.1 to 30 ng/ml) and for the diagnostic gray zone of 2.1-10 ng/ml. For the two groups, the free to total PSA ratio had a higher specificity than total-PSA for all sensitivity levels. Cut-off values were found to, vary with prostate weight. Although free to total PSA ratio demonstrated better performances than total-PSA, its use in screening appears problematic, due to the low prevalence of prostate cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077456"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077456"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077456; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45077456]").text(description); $(".js-view-count[data-work-id=45077456]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45077456; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='45077456']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=45077456]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":45077456,"title":"Free to total prostate鈥恠pecific antigen (PSA) ratio is superior to total鈥怭SA in differentiating benign prostate hypertrophy from prostate cancer","internal_url":"https://www.academia.edu/45077456/Free_to_total_prostate_specific_antigen_PSA_ratio_is_superior_to_total_PSA_in_differentiating_benign_prostate_hypertrophy_from_prostate_cancer","owner_id":185020643,"coauthors_can_edit":true,"owner":{"id":185020643,"first_name":"Bertrand","middle_initials":null,"last_name":"TOMBAL","page_name":"BertrandTOMBAL","domain_name":"uclep","created_at":"2021-02-08T04:37:44.256-08:00","display_name":"Bertrand TOMBAL","url":"https://uclep.academia.edu/BertrandTOMBAL"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077455"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077455/Magnetic_resonance_imaging_of_the_axial_skeleton_enables_objective_measurement_of_tumor_response_on_prostate_cancer_bone_metastases"><img alt="Research paper thumbnail of Magnetic resonance imaging of the axial skeleton enables objective measurement of tumor response on prostate cancer bone metastases" class="work-thumbnail" src="https://attachments.academia-assets.com/65635293/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077455/Magnetic_resonance_imaging_of_the_axial_skeleton_enables_objective_measurement_of_tumor_response_on_prostate_cancer_bone_metastases">Magnetic resonance imaging of the axial skeleton enables objective measurement of tumor response on prostate cancer bone metastases</a></div><div class="wp-workCard_item"><span>The Prostate</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND. There is currently no technique to image quantitatively bone metastases. Here, we ass...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND. There is currently no technique to image quantitatively bone metastases. Here, we assessed the value of MRI of the axial skeleton (AS-MRI) as a single step technique to quantify bone metastases and measure tumor response. METHODS. AS-MRI was performed in 38 patients before receiving chemotherapy for metastatic HRPCa, in addition to PSA, computed tomography of the thorax, abdomen, and pelvis [CT-TAP]; and Tc-99m bone scintigraphy. A second AS-MRI was performed in 20 patients who completed 6 months of chemotherapy. Evaluation of tumor response was performed using RECIST. RESULTS. Only 11 patients (29%) had RECIST measurable metastases in soft-tissues or lymph nodes on baseline CT-TAP. AS-MRI identified a diffuse infiltration of the bone marrow in 8 patients and focal measurable metastatic lesions in 25 patients (65%), therefore, doubling the proportion of patients with measurable lesions. Transposing RECIST on AS-MRI in 20 patients who completed 6 months of treatment, allows the accurate estimation of complete response (n 录 2), partial response (n 录 2), stable disease (n 录 5), or tumor progression (n 录 11), as it is done using CT-TAP in soft tissue solid metastases. CONCLUSIONS. MRI of axial skeleton enables precise measurement and follow-up of bone metastases as it is for other soft-tissue metastasis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ec4c3e4a3a13f01f7b08a69a75a27974" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635293,"asset_id":45077455,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635293/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077455"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077455"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077455; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077454"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077454/Prognostic_value_of_circulating_prostate_cells_in_patients_with_a_rising_PSA_after_radical_prostatectomy"><img alt="Research paper thumbnail of Prognostic value of circulating prostate cells in patients with a rising PSA after radical prostatectomy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077454/Prognostic_value_of_circulating_prostate_cells_in_patients_with_a_rising_PSA_after_radical_prostatectomy">Prognostic value of circulating prostate cells in patients with a rising PSA after radical prostatectomy</a></div><div class="wp-workCard_item"><span>The Prostate</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To predict poor outcome in patients with a biochemical recurrence (rising PSA) after radical pros...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To predict poor outcome in patients with a biochemical recurrence (rising PSA) after radical prostatectomy (RP), urologists rely primarily on Gleason score, PSA doubling time, and time from surgery to biochemical (i.e., PSA) recurrence. In the present study, we assess the value of RT-PCR detection circulating prostate cells in blood of patients with a rising PSA. RNA from blood samples was obtained from 55 patients with a rising PSA and from 45 patients without evidence of biochemical failure (PSA &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.1 ng/ml). Both groups were matched for age, Gleason score, pT stage, and interval between radical prostatectomy and PCR testing. PSA positive cells were detected in 1/45 (2%) patients without a PSA recurrence and 19/55 (34%) patients with a PSA recurrence. In the rising PSA group, mean PSA doubling time was significantly shorter in patients with positive RT-PCR (5 months) than in patients with negative RT-PCR (16 months; P = 0.001). An earlier onset of recurrence was also detected in patients with a positive RT-PCR (31 months for positive RT-PCR vs. 50 months for negative RT-PCR) but this result did not achieve statistical significance (P = 0.102). Salvage radiation therapy was administered in 15 patients. Three of the five patients with a positive RT-PCR progressed during radiotherapy whereas 7 of the 10 patients with a negative RT-PCR obtained a complete response and none have progressed. These preliminary results suggest that RT-PCR detection of prostate cells in blood of patients after RP correlates with rapidly progressing biochemical failure after RP.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077454"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077454"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077454; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="33219315"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/33219315/294_in_High_Risk_Prostate_Cancer_3_or_More_Positive_Nodes_at_Radical_Prostatectomy_Represent_an_Independent_Predictor_of_Worse_CSS_While_1_or_2_Positive_Nodes_Do_Not_Influence_CSS"><img alt="Research paper thumbnail of 294 in High-Risk Prostate Cancer, 3 or More Positive Nodes at Radical Prostatectomy Represent an Independent Predictor of Worse CSS, While 1 or 2 Positive Nodes Do Not Influence CSS" class="work-thumbnail" src="https://attachments.academia-assets.com/53296886/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/33219315/294_in_High_Risk_Prostate_Cancer_3_or_More_Positive_Nodes_at_Radical_Prostatectomy_Represent_an_Independent_Predictor_of_Worse_CSS_While_1_or_2_Positive_Nodes_Do_Not_Influence_CSS">294 in High-Risk Prostate Cancer, 3 or More Positive Nodes at Radical Prostatectomy Represent an Independent Predictor of Worse CSS, While 1 or 2 Positive Nodes Do Not Influence CSS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/BrunoFrea">Bruno Frea</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://uclep.academia.edu/BertrandTOMBAL">Bertrand TOMBAL</a></span></div><div class="wp-workCard_item"><span>J Urol</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">INTRODUCTION AND OBJECTIVES: The finding of nodal metastases (N烯) at the time of radical prostate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">INTRODUCTION AND OBJECTIVES: The finding of nodal metastases (N烯) at the time of radical prostatectomy (RP) and pelvic</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e66872007165d10ef8adca79cb4f850" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53296886,"asset_id":33219315,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53296886/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="33219315"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="33219315"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33219315; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077453"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/45077453/291_in_High_Risk_Prostate_Cancer_a_Pelvic_Lymph_Node_Dissection_with_20_Lymph_Nodes_Removed_at_Radical_Prostatectomy_Significantly_Improves_Overall_Survival"><img alt="Research paper thumbnail of 291 in High-Risk Prostate Cancer, a Pelvic Lymph Node Dissection with >20 Lymph Nodes Removed at Radical Prostatectomy Significantly Improves Overall Survival" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/45077453/291_in_High_Risk_Prostate_Cancer_a_Pelvic_Lymph_Node_Dissection_with_20_Lymph_Nodes_Removed_at_Radical_Prostatectomy_Significantly_Improves_Overall_Survival">291 in High-Risk Prostate Cancer, a Pelvic Lymph Node Dissection with >20 Lymph Nodes Removed at Radical Prostatectomy Significantly Improves Overall Survival</a></div><div class="wp-workCard_item"><span>The Journal of Urology</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077453"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077453"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077453; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45077452"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45077452/The_application_of_adjuvant_autologous_antravesical_macrophage_cell_therapy_vs_BCG_in_non_muscle_invasive_bladder_cancer_a_multicenter_randomized_trial"><img alt="Research paper thumbnail of The application of adjuvant autologous antravesical macrophage cell therapy vs. BCG in non-muscle invasive bladder cancer: a multicenter, randomized trial" class="work-thumbnail" src="https://attachments.academia-assets.com/65635289/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45077452/The_application_of_adjuvant_autologous_antravesical_macrophage_cell_therapy_vs_BCG_in_non_muscle_invasive_bladder_cancer_a_multicenter_randomized_trial">The application of adjuvant autologous antravesical macrophage cell therapy vs. BCG in non-muscle invasive bladder cancer: a multicenter, randomized trial</a></div><div class="wp-workCard_item"><span>Journal of Translational Medicine</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: While adjuvant immunotherapy with Bacille Calmette Gu茅rin (BCG) is effective in non...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: While adjuvant immunotherapy with Bacille Calmette Gu茅rin (BCG) is effective in non-muscle-invasive bladder cancer (BC), adverse events (AEs) are considerable. Monocyte-derived activated killer cells (MAK) are discussed as essential in antitumoural immunoresponse, but their application may imply risks. The present trial compared autologous intravesical macrophage cell therapy (BEXIDEM 庐 ) to BCG in patients after transurethral resection (TURB) of BC.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b9be4f6df71a112f8ec57b7adc19a5fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65635289,"asset_id":45077452,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65635289/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45077452"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45077452"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45077452; 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