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He directs a laboratory of around a dozen scientists who work in photodynamic therapy and photobiomodulation. He has published 346 peer-reviewed articles, is Editor or Associate Editor for 10 journals and serves on NIH Study-Sections. He has an h-factor of 77 and over 21,700 citations. He has authored/edited 11 proceedings volumes together with ten other major textbooks on PDT and photomedicine. Dr Hamblin was honored by election as a Fellow of SPIE in 2011, and received the 1st Endre Mester Lifetime Achievement Award from NAALT in 2017.<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="44782898">View All (6)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="44782898" href="https://www.academia.edu/Documents/in/Procrastination"><div id="js-react-on-rails-context" style="display:none" 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data-dom-id="Pill-react-component-f6b21c6d-179b-4a3c-aba3-51ea2b688641"></div> <div id="Pill-react-component-f6b21c6d-179b-4a3c-aba3-51ea2b688641"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="44782898" href="https://www.academia.edu/Documents/in/Cholesterol"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Cholesterol"]}" data-trace="false" data-dom-id="Pill-react-component-b3780e75-95d1-4484-a1fe-5b61874e4467"></div> <div id="Pill-react-component-b3780e75-95d1-4484-a1fe-5b61874e4467"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Mike Hamblin</h3></div><div class="js-work-strip profile--work_container" data-work-id="30900199"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900199/Wound_Healing_Properties_of_Chitosan_and_Its_Use_in_Wound_Dressing_Biopharmaceuticals"><img alt="Research paper thumbnail of Wound-Healing Properties of Chitosan and Its Use in Wound Dressing Biopharmaceuticals" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900199/Wound_Healing_Properties_of_Chitosan_and_Its_Use_in_Wound_Dressing_Biopharmaceuticals">Wound-Healing Properties of Chitosan and Its Use in Wound Dressing Biopharmaceuticals</a></div><div class="wp-workCard_item"><span>Delivery, Targeting and Polymer Therapeutics</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT This chapter contains sections titled: IntroductionBrief Review of Wound RepairWound-Hea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT This chapter contains sections titled: IntroductionBrief Review of Wound RepairWound-Healing Effects of ChitosanChitosan for Wound Therapeutics DeliveryConclusions and Future PerspectivesAcknowledgmentsReferences</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900199"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900199"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900199; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900198"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900198/Biodistribution_of_charged_F_ab_2_photoimmunoconjugates_in_a_xenograft_model_of_ovarian_cancer"><img alt="Research paper thumbnail of Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/51325591/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900198/Biodistribution_of_charged_F_ab_2_photoimmunoconjugates_in_a_xenograft_model_of_ovarian_cancer">Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer</a></div><div class="wp-workCard_item"><span>British journal of cancer</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a x...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorin(e6)c(e6) was attached site specifically to the F(ab&#39;)2 fragment of the murine monoclonal antibody OC125, directed against human ovarian cancer cells, via poly-1-lysine linkers carrying cationic or anionic charges. Preservation of immunoreactivity was checked by enzyme-linked immunosorbent assay (ELISA). PICs were radiolabelled with 125I and compared with non-specific rabbit IgG PICs after intraperitoneal (i.p.) injection into nude mice. Samples were taken from normal organs and tumour at 3 h and 24 h. Tumour to normal 125I ratios showed that the cationic OC125F(ab&#39;)2 PIC had the highest tumour selectivity. Ratios for c(e6) were uniformly higher than for 125I, indicating that c(e6) became separated from 125I. OC125F(ab&#39;)2 gave highest tissue values of 125I, followed by cationic OC125F(ab&#39;)2 PIC; other species were ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1c21763b8a962dd86f271936bf8fe000" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325591,"asset_id":30900198,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325591/download_file?st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900198"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900198"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900198; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900198]").text(description); $(".js-view-count[data-work-id=30900198]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900198; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900198']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900198, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1c21763b8a962dd86f271936bf8fe000" } } $('.js-work-strip[data-work-id=30900198]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900198,"title":"Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer","translated_title":"","metadata":{"abstract":"The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorin(e6)c(e6) was attached site specifically to the F(ab\u0026#39;)2 fragment of the murine monoclonal antibody OC125, directed against human ovarian cancer cells, via poly-1-lysine linkers carrying cationic or anionic charges. Preservation of immunoreactivity was checked by enzyme-linked immunosorbent assay (ELISA). PICs were radiolabelled with 125I and compared with non-specific rabbit IgG PICs after intraperitoneal (i.p.) injection into nude mice. Samples were taken from normal organs and tumour at 3 h and 24 h. Tumour to normal 125I ratios showed that the cationic OC125F(ab\u0026#39;)2 PIC had the highest tumour selectivity. Ratios for c(e6) were uniformly higher than for 125I, indicating that c(e6) became separated from 125I. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900197"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900197/Photodynamic_therapy_plus_regulatory_T_cell_depletion_produces_immunity_against_a_mouse_tumour_that_expresses_a_self_antigen"><img alt="Research paper thumbnail of Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen" class="work-thumbnail" src="https://attachments.academia-assets.com/51325589/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900197/Photodynamic_therapy_plus_regulatory_T_cell_depletion_produces_immunity_against_a_mouse_tumour_that_expresses_a_self_antigen">Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen</a></div><div class="wp-workCard_item"><span>British journal of cancer</span><span>, Jan 15, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-me...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-mediated immunity can be potentiated by T regulatory cell (Treg) depletion. We investigated whether the combination of PDT with cyclophosphamide (CY) could foster immunity against wild-type tumours expressing self-antigen (gp70). Mice with CT26 tumours were treated with PDT alone or in combination with low-dose CY. T regulatory cell numbers and transforming growth factor-β (TGF-β) levels were measured at several time points after treatment. Mice cured by PDT+CY were rechallenged with CT26 and monitored for long-term survival. Photodynamic therapy+CY led to complete tumour regression and long-term survival in 90% of treated mice while the absolute numbers of Treg decreased after PDT+CY and the TGF-β levels were reduced to a level comparable to naïve mice. Sixty-five percent of the mice treated with PDT+CY that survived over 90 days tumour free rejected the rechallenge with the same tumour w...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5a92d2b0d7ce09c4c20247bcffbc815b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325589,"asset_id":30900197,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325589/download_file?st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900197"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900197"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900197; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900197]").text(description); $(".js-view-count[data-work-id=30900197]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900197; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900197']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900197, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5a92d2b0d7ce09c4c20247bcffbc815b" } } $('.js-work-strip[data-work-id=30900197]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900197,"title":"Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen","translated_title":"","metadata":{"abstract":"Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-mediated immunity can be potentiated by T regulatory cell (Treg) depletion. 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Sixty-five percent of the mice treated with PDT+CY that survived over 90 days tumour free rejected the rechallenge with the same tumour w...","publication_date":{"day":15,"month":1,"year":2013,"errors":{}},"publication_name":"British journal of cancer"},"translated_abstract":"Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-mediated immunity can be potentiated by T regulatory cell (Treg) depletion. We investigated whether the combination of PDT with cyclophosphamide (CY) could foster immunity against wild-type tumours expressing self-antigen (gp70). Mice with CT26 tumours were treated with PDT alone or in combination with low-dose CY. T regulatory cell numbers and transforming growth factor-β (TGF-β) levels were measured at several time points after treatment. Mice cured by PDT+CY were rechallenged with CT26 and monitored for long-term survival. Photodynamic therapy+CY led to complete tumour regression and long-term survival in 90% of treated mice while the absolute numbers of Treg decreased after PDT+CY and the TGF-β levels were reduced to a level comparable to naïve mice. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900196"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900196/Targeted_photodestruction_of_human_colon_cancer_cells_using_charged_17_1A_chlorin_e6_immunoconjugates"><img alt="Research paper thumbnail of Targeted photodestruction of human colon cancer cells using charged 17.1A chlorin e6 immunoconjugates" class="work-thumbnail" src="https://attachments.academia-assets.com/51325588/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900196/Targeted_photodestruction_of_human_colon_cancer_cells_using_charged_17_1A_chlorin_e6_immunoconjugates">Targeted photodestruction of human colon cancer cells using charged 17.1A chlorin e6 immunoconjugates</a></div><div class="wp-workCard_item"><span>British journal of cancer</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The goal of this study was to develop a strategy for the selective destruction of colorectal canc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The goal of this study was to develop a strategy for the selective destruction of colorectal cancer cells. Towards this end, photoimmunoconjugates were prepared between the anti-colon cancer monoclonal antibody 17.1A and the photosensitizer (PS) chlorin(e6) (c(e6)). Polylysine linkers bearing several c(e6) molecules were covalently attached in a site-specific manner to partially reduced IgG molecules, which allowed photoimmunoconjugates to bear either cationic or anionic charges. The conjugates retained immunoreactivity as shown by enzyme-linked immunosorbent assays and by competition studies with native antibody. The overall charge on the photoimmunoconjugate was an important determinant of PS delivery. The cationic photoimmunoconjugate delivered 4 times more c(e6) to the cells than the anionic photoimmunoconjugate, and both 17.1A conjugates showed, in comparison to non-specific rabbit IgG conjugates, selectivity for antigen-positive target cells. 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Towards this end, photoimmunoconjugates were prepared between the anti-colon cancer monoclonal antibody 17.1A and the photosensitizer (PS) chlorin(e6) (c(e6)). Polylysine linkers bearing several c(e6) molecules were covalently attached in a site-specific manner to partially reduced IgG molecules, which allowed photoimmunoconjugates to bear either cationic or anionic charges. The conjugates retained immunoreactivity as shown by enzyme-linked immunosorbent assays and by competition studies with native antibody. The overall charge on the photoimmunoconjugate was an important determinant of PS delivery. The cationic photoimmunoconjugate delivered 4 times more c(e6) to the cells than the anionic photoimmunoconjugate, and both 17.1A conjugates showed, in comparison to non-specific rabbit IgG conjugates, selectivity for antigen-positive target cells. Illumination with only 3 J cm(-2) ...","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"British journal of cancer"},"translated_abstract":"The goal of this study was to develop a strategy for the selective destruction of colorectal cancer cells. Towards this end, photoimmunoconjugates were prepared between the anti-colon cancer monoclonal antibody 17.1A and the photosensitizer (PS) chlorin(e6) (c(e6)). Polylysine linkers bearing several c(e6) molecules were covalently attached in a site-specific manner to partially reduced IgG molecules, which allowed photoimmunoconjugates to bear either cationic or anionic charges. The conjugates retained immunoreactivity as shown by enzyme-linked immunosorbent assays and by competition studies with native antibody. The overall charge on the photoimmunoconjugate was an important determinant of PS delivery. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900195"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900195/Photodynamic_therapy_of_orthotopic_prostate_cancer_with_benzoporphyrin_derivative_local_control_and_distant_metastasis"><img alt="Research paper thumbnail of Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis" class="work-thumbnail" src="https://attachments.academia-assets.com/51325590/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900195/Photodynamic_therapy_of_orthotopic_prostate_cancer_with_benzoporphyrin_derivative_local_control_and_distant_metastasis">Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is the first report of photodynamic therapy (PDT) in an orthotopic prostate tumor model and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is the first report of photodynamic therapy (PDT) in an orthotopic prostate tumor model and shows that PDT combined with surgery (tumor bed sterilization) gave significant local control of the primary tumor and significant reduction in distant metastases. By contrast, either treatment alone (surgery or PDT) gave relatively poorer local control, and PDT gave a significant increase in the mean number of lung metastases. The MatLyLu variant of the Dunning 3327 rat prostate cancer cell line, which has been selected to be metastatic to lymph nodes and lungs, was injected into the ventral lobe of the rat prostate. After 7 days, tumors were either treated by surgical removal of the ventral lobe, PDT with liposomal benzoporphyrin derivative monoacid ring A, or a combination of surgery, followed by PDT of the tumor bed. Results after 21 days showed a reduction in prostate tumor weight in all groups compared with controls, which became highly significant only for the combination group (1...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="336a8de4df568f6e0b6130cfb0c8fb80" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325590,"asset_id":30900195,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325590/download_file?st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900195"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900195"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900195; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900195]").text(description); $(".js-view-count[data-work-id=30900195]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900195; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900195']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900195, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "336a8de4df568f6e0b6130cfb0c8fb80" } } $('.js-work-strip[data-work-id=30900195]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900195,"title":"Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis","translated_title":"","metadata":{"abstract":"This is the first report of photodynamic therapy (PDT) in an orthotopic prostate tumor model and shows that PDT combined with surgery (tumor bed sterilization) gave significant local control of the primary tumor and significant reduction in distant metastases. By contrast, either treatment alone (surgery or PDT) gave relatively poorer local control, and PDT gave a significant increase in the mean number of lung metastases. The MatLyLu variant of the Dunning 3327 rat prostate cancer cell line, which has been selected to be metastatic to lymph nodes and lungs, was injected into the ventral lobe of the rat prostate. After 7 days, tumors were either treated by surgical removal of the ventral lobe, PDT with liposomal benzoporphyrin derivative monoacid ring A, or a combination of surgery, followed by PDT of the tumor bed. Results after 21 days showed a reduction in prostate tumor weight in all groups compared with controls, which became highly significant only for the combination group (1...","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"This is the first report of photodynamic therapy (PDT) in an orthotopic prostate tumor model and shows that PDT combined with surgery (tumor bed sterilization) gave significant local control of the primary tumor and significant reduction in distant metastases. By contrast, either treatment alone (surgery or PDT) gave relatively poorer local control, and PDT gave a significant increase in the mean number of lung metastases. The MatLyLu variant of the Dunning 3327 rat prostate cancer cell line, which has been selected to be metastatic to lymph nodes and lungs, was injected into the ventral lobe of the rat prostate. After 7 days, tumors were either treated by surgical removal of the ventral lobe, PDT with liposomal benzoporphyrin derivative monoacid ring A, or a combination of surgery, followed by PDT of the tumor bed. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900194/Effect_of_charge_on_the_interaction_of_site_specific_photoimmunoconjugates_with_human_ovarian_cancer_cells"><img alt="Research paper thumbnail of Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells" class="work-thumbnail" src="https://attachments.academia-assets.com/51325594/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900194/Effect_of_charge_on_the_interaction_of_site_specific_photoimmunoconjugates_with_human_ovarian_cancer_cells">Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, Jan 15, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate (PIC) was demonstrated. A site-specific conjugation strategy was developed to attach the photosensitizer chlorin(e6) (c(e6)) to the F(ab&#39;)2 fragment of the murine antiovarian cancer monoclonal antibody OC125. Poly-L-lysine linkers carrying c(e6) with a cationic charge or by polysuccinylation with an anionic charge were used and covalently attached to partially reduced antibody via a heterobifunctional reagent. PICs were purified by column chromatography and were also radiolabeled with 125I. PIC binding and uptake were studied with a human ovarian cancer cell line, NIH-OVCAR-5, and a nonantigen-expressing colon cancer cell line, SW1116, and the data were compared with the binding and uptake of nonspecific rabbit IgG PICs. PICs with both cationic and anionic charges preserved antigen binding as shown by competition studies with native antibody, but the cationic PIC had up to 17 times h...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d00915fde99c3147f05289f791280f08" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325594,"asset_id":30900194,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325594/download_file?st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900194]").text(description); $(".js-view-count[data-work-id=30900194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900194, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d00915fde99c3147f05289f791280f08" } } $('.js-work-strip[data-work-id=30900194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900194,"title":"Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells","translated_title":"","metadata":{"abstract":"A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate (PIC) was demonstrated. A site-specific conjugation strategy was developed to attach the photosensitizer chlorin(e6) (c(e6)) to the F(ab\u0026#39;)2 fragment of the murine antiovarian cancer monoclonal antibody OC125. Poly-L-lysine linkers carrying c(e6) with a cationic charge or by polysuccinylation with an anionic charge were used and covalently attached to partially reduced antibody via a heterobifunctional reagent. PICs were purified by column chromatography and were also radiolabeled with 125I. PIC binding and uptake were studied with a human ovarian cancer cell line, NIH-OVCAR-5, and a nonantigen-expressing colon cancer cell line, SW1116, and the data were compared with the binding and uptake of nonspecific rabbit IgG PICs. PICs with both cationic and anionic charges preserved antigen binding as shown by competition studies with native antibody, but the cationic PIC had up to 17 times h...","publication_date":{"day":15,"month":1,"year":1996,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate (PIC) was demonstrated. A site-specific conjugation strategy was developed to attach the photosensitizer chlorin(e6) (c(e6)) to the F(ab\u0026#39;)2 fragment of the murine antiovarian cancer monoclonal antibody OC125. Poly-L-lysine linkers carrying c(e6) with a cationic charge or by polysuccinylation with an anionic charge were used and covalently attached to partially reduced antibody via a heterobifunctional reagent. PICs were purified by column chromatography and were also radiolabeled with 125I. PIC binding and uptake were studied with a human ovarian cancer cell line, NIH-OVCAR-5, and a nonantigen-expressing colon cancer cell line, SW1116, and the data were compared with the binding and uptake of nonspecific rabbit IgG PICs. PICs with both cationic and anionic charges preserved antigen binding as shown by competition studies with native antibody, but the cationic PIC had up to 17 times h...","internal_url":"https://www.academia.edu/30900194/Effect_of_charge_on_the_interaction_of_site_specific_photoimmunoconjugates_with_human_ovarian_cancer_cells","translated_internal_url":"","created_at":"2017-01-12T15:25:37.317-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44782898,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":51325594,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51325594/thumbnails/1.jpg","file_name":"5205.full.pdf","download_url":"https://www.academia.edu/attachments/51325594/download_file?st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_charge_on_the_interaction_of_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51325594/5205.full-libre.pdf?1484264030=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_charge_on_the_interaction_of_s.pdf\u0026Expires=1732727687\u0026Signature=JxMkZbjxj-tEqbutuZqmCIbug8DlBxDeaZW1yaI0sv8OUuF~iik4GztSa4vCocfb8sVE4Gth6UV~zCW4bjDuD5tM54sbRVCTiqMghQkFNYIUBamJKqHTXquh8HIaO9xMxvuKZrsdkL-uvc6IJn0iEMKLavZNGfMHkS74XQd~aEgOECp5kBxGr81Ca2YDjlD9quALH8b0ZQ5CkgU89hPP0O-m~lo4tBmmk6BgxEXC0D8u4LJ~J4l~v5G3drTB~ulYHFtrXzx~jvmjia4bDbTq6B6E8-Wt1elf7YvyFl5z5cwH12tm53pRHANKsYFAANhwpFR9NEzbtT7oV3upTNSe9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_of_charge_on_the_interaction_of_site_specific_photoimmunoconjugates_with_human_ovarian_cancer_cells","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":44782898,"first_name":"Mike","middle_initials":null,"last_name":"Hamblin","page_name":"MikeHamblin","domain_name":"hms-harvard","created_at":"2016-03-09T09:35:44.332-08:00","display_name":"Mike Hamblin","url":"https://hms-harvard.academia.edu/MikeHamblin"},"attachments":[{"id":51325594,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51325594/thumbnails/1.jpg","file_name":"5205.full.pdf","download_url":"https://www.academia.edu/attachments/51325594/download_file?st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_charge_on_the_interaction_of_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51325594/5205.full-libre.pdf?1484264030=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_charge_on_the_interaction_of_s.pdf\u0026Expires=1732727687\u0026Signature=JxMkZbjxj-tEqbutuZqmCIbug8DlBxDeaZW1yaI0sv8OUuF~iik4GztSa4vCocfb8sVE4Gth6UV~zCW4bjDuD5tM54sbRVCTiqMghQkFNYIUBamJKqHTXquh8HIaO9xMxvuKZrsdkL-uvc6IJn0iEMKLavZNGfMHkS74XQd~aEgOECp5kBxGr81Ca2YDjlD9quALH8b0ZQ5CkgU89hPP0O-m~lo4tBmmk6BgxEXC0D8u4LJ~J4l~v5G3drTB~ulYHFtrXzx~jvmjia4bDbTq6B6E8-Wt1elf7YvyFl5z5cwH12tm53pRHANKsYFAANhwpFR9NEzbtT7oV3upTNSe9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7700,"name":"Fluorescence Microscopy","url":"https://www.academia.edu/Documents/in/Fluorescence_Microscopy"},{"id":51613,"name":"Internalization","url":"https://www.academia.edu/Documents/in/Internalization"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":133177,"name":"Temperature","url":"https://www.academia.edu/Documents/in/Temperature"},{"id":869175,"name":"Ovary","url":"https://www.academia.edu/Documents/in/Ovary"},{"id":1013858,"name":"Cations","url":"https://www.academia.edu/Documents/in/Cations"},{"id":1371571,"name":"Internalisation","url":"https://www.academia.edu/Documents/in/Internalisation"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900193"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900193/myo_Inositol_phosphorothioates_phosphatase_resistant_analogues_of_myo_inositol_phosphates_Synthesis_of_DL_myo_inositol_1_4_bisphosphate_and_DL_myo_inositol_1_4_bisphosphorothioate"><img alt="Research paper thumbnail of myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of DL-myo-inositol 1,4-bisphosphate and DL-myo-inositol 1,4-bisphosphorothioate" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900193/myo_Inositol_phosphorothioates_phosphatase_resistant_analogues_of_myo_inositol_phosphates_Synthesis_of_DL_myo_inositol_1_4_bisphosphate_and_DL_myo_inositol_1_4_bisphosphorothioate">myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of DL-myo-inositol 1,4-bisphosphate and DL-myo-inositol 1,4-bisphosphorothioate</a></div><div class="wp-workCard_item"><span>The Biochemical journal</span><span>, Jan 15, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol 1,4-bisphosphate, and an analogue, the 1,4-bisphosphorothioate, are reported, by using phosphite chemistry on (+/-)-1,2:4,5-di-isopropylidene-myo-inositol. The synthesis of (+/-)-1,2:4,5-di-isopropylidene 3,6-bis[di-(2-cyanoethyl)]phosphite provides an intermediate that can be oxidized to either the corresponding bisphosphate or bisphosphorothioate. myo-Inositol phosphorothioates are proposed as novel analogues of myo-inositol phosphates; their resistance to phosphatase-catalysed breakdown is reported.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900193"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900193"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900193; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900193]").text(description); $(".js-view-count[data-work-id=30900193]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900193; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900193']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900193, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30900193]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900193,"title":"myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of DL-myo-inositol 1,4-bisphosphate and DL-myo-inositol 1,4-bisphosphorothioate","translated_title":"","metadata":{"abstract":"Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol 1,4-bisphosphate, and an analogue, the 1,4-bisphosphorothioate, are reported, by using phosphite chemistry on (+/-)-1,2:4,5-di-isopropylidene-myo-inositol. The synthesis of (+/-)-1,2:4,5-di-isopropylidene 3,6-bis[di-(2-cyanoethyl)]phosphite provides an intermediate that can be oxidized to either the corresponding bisphosphate or bisphosphorothioate. myo-Inositol phosphorothioates are proposed as novel analogues of myo-inositol phosphates; their resistance to phosphatase-catalysed breakdown is reported.","publication_date":{"day":15,"month":1,"year":1987,"errors":{}},"publication_name":"The Biochemical journal"},"translated_abstract":"Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol 1,4-bisphosphate, and an analogue, the 1,4-bisphosphorothioate, are reported, by using phosphite chemistry on (+/-)-1,2:4,5-di-isopropylidene-myo-inositol. The synthesis of (+/-)-1,2:4,5-di-isopropylidene 3,6-bis[di-(2-cyanoethyl)]phosphite provides an intermediate that can be oxidized to either the corresponding bisphosphate or bisphosphorothioate. myo-Inositol phosphorothioates are proposed as novel analogues of myo-inositol phosphates; their resistance to phosphatase-catalysed breakdown is reported.","internal_url":"https://www.academia.edu/30900193/myo_Inositol_phosphorothioates_phosphatase_resistant_analogues_of_myo_inositol_phosphates_Synthesis_of_DL_myo_inositol_1_4_bisphosphate_and_DL_myo_inositol_1_4_bisphosphorothioate","translated_internal_url":"","created_at":"2017-01-12T15:25:36.969-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44782898,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"myo_Inositol_phosphorothioates_phosphatase_resistant_analogues_of_myo_inositol_phosphates_Synthesis_of_DL_myo_inositol_1_4_bisphosphate_and_DL_myo_inositol_1_4_bisphosphorothioate","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44782898,"first_name":"Mike","middle_initials":null,"last_name":"Hamblin","page_name":"MikeHamblin","domain_name":"hms-harvard","created_at":"2016-03-09T09:35:44.332-08:00","display_name":"Mike Hamblin","url":"https://hms-harvard.academia.edu/MikeHamblin"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":176525,"name":"Biochemical","url":"https://www.academia.edu/Documents/in/Biochemical"},{"id":204435,"name":"Alkaline phosphatase","url":"https://www.academia.edu/Documents/in/Alkaline_phosphatase"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":2586983,"name":"Inositol Phosphates","url":"https://www.academia.edu/Documents/in/Inositol_Phosphates"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900192/Mung_bean_Phaseolus_aureus_nuclease_A_mechanistic_investigation_of_the_DNA_cleavage_reaction_using_a_dinucleoside_phosphorothioate"><img alt="Research paper thumbnail of Mung bean (Phaseolus aureus) nuclease. A mechanistic investigation of the DNA-cleavage reaction using a dinucleoside phosphorothioate" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900192/Mung_bean_Phaseolus_aureus_nuclease_A_mechanistic_investigation_of_the_DNA_cleavage_reaction_using_a_dinucleoside_phosphorothioate">Mung bean (Phaseolus aureus) nuclease. A mechanistic investigation of the DNA-cleavage reaction using a dinucleoside phosphorothioate</a></div><div class="wp-workCard_item"><span>The Biochemical journal</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mung-bean (Phaseolus aureus) nuclease has been found to cleave the Sp diastereoisomer of 5&#39;-O...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mung-bean (Phaseolus aureus) nuclease has been found to cleave the Sp diastereoisomer of 5&#39;-O-thymidyl 3&#39;-O-(2&#39;-deoxyadenosyl)phosphorothioate, (Sp)-d[Ap(S)T], in 18O-labelled water with inversion of configuration at phosphorus to give (Sp)-thymidine 5&#39;-[16O, 18O]phosphorothioate, the stereochemistry of which was deduced by methylation to (Rp,Sp)-thymidine 5&#39;-S-methyl-O-methyl-[16O,18O]phosphorothioate and 31P-n.m.r. analysis. This result is consistent with a mechanism involving a direct &#39;in-line&#39; attack of water on DNA for the nuclease-catalysed reaction without the involvement of a covalent nucleotidylated-enzyme intermediate.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900192]").text(description); $(".js-view-count[data-work-id=30900192]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900192; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900192']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900192, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30900192]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900192,"title":"Mung bean (Phaseolus aureus) nuclease. A mechanistic investigation of the DNA-cleavage reaction using a dinucleoside phosphorothioate","translated_title":"","metadata":{"abstract":"Mung-bean (Phaseolus aureus) nuclease has been found to cleave the Sp diastereoisomer of 5\u0026#39;-O-thymidyl 3\u0026#39;-O-(2\u0026#39;-deoxyadenosyl)phosphorothioate, (Sp)-d[Ap(S)T], in 18O-labelled water with inversion of configuration at phosphorus to give (Sp)-thymidine 5\u0026#39;-[16O, 18O]phosphorothioate, the stereochemistry of which was deduced by methylation to (Rp,Sp)-thymidine 5\u0026#39;-S-methyl-O-methyl-[16O,18O]phosphorothioate and 31P-n.m.r. analysis. This result is consistent with a mechanism involving a direct \u0026#39;in-line\u0026#39; attack of water on DNA for the nuclease-catalysed reaction without the involvement of a covalent nucleotidylated-enzyme intermediate.","publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"The Biochemical journal"},"translated_abstract":"Mung-bean (Phaseolus aureus) nuclease has been found to cleave the Sp diastereoisomer of 5\u0026#39;-O-thymidyl 3\u0026#39;-O-(2\u0026#39;-deoxyadenosyl)phosphorothioate, (Sp)-d[Ap(S)T], in 18O-labelled water with inversion of configuration at phosphorus to give (Sp)-thymidine 5\u0026#39;-[16O, 18O]phosphorothioate, the stereochemistry of which was deduced by methylation to (Rp,Sp)-thymidine 5\u0026#39;-S-methyl-O-methyl-[16O,18O]phosphorothioate and 31P-n.m.r. analysis. This result is consistent with a mechanism involving a direct \u0026#39;in-line\u0026#39; attack of water on DNA for the nuclease-catalysed reaction without the involvement of a covalent nucleotidylated-enzyme intermediate.","internal_url":"https://www.academia.edu/30900192/Mung_bean_Phaseolus_aureus_nuclease_A_mechanistic_investigation_of_the_DNA_cleavage_reaction_using_a_dinucleoside_phosphorothioate","translated_internal_url":"","created_at":"2017-01-12T15:25:36.605-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44782898,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Mung_bean_Phaseolus_aureus_nuclease_A_mechanistic_investigation_of_the_DNA_cleavage_reaction_using_a_dinucleoside_phosphorothioate","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44782898,"first_name":"Mike","middle_initials":null,"last_name":"Hamblin","page_name":"MikeHamblin","domain_name":"hms-harvard","created_at":"2016-03-09T09:35:44.332-08:00","display_name":"Mike Hamblin","url":"https://hms-harvard.academia.edu/MikeHamblin"},"attachments":[],"research_interests":[{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA"},{"id":87651,"name":"Methylation","url":"https://www.academia.edu/Documents/in/Methylation"},{"id":176525,"name":"Biochemical","url":"https://www.academia.edu/Documents/in/Biochemical"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":1030794,"name":"Hydrolysis","url":"https://www.academia.edu/Documents/in/Hydrolysis"},{"id":1362652,"name":"Nucleic Acid Conformation","url":"https://www.academia.edu/Documents/in/Nucleic_Acid_Conformation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900191"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900191/Low_level_laser_therapy_LLLT_reduces_oxidative_stress_in_primary_cortical_neurons_in_vitro"><img alt="Research paper thumbnail of Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/51325593/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900191/Low_level_laser_therapy_LLLT_reduces_oxidative_stress_in_primary_cortical_neurons_in_vitro">Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro</a></div><div class="wp-workCard_item"><span>Journal of biophotonics</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Low-level laser (light) therapy (LLLT) involves absorption of photons being in the mitochondria o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Low-level laser (light) therapy (LLLT) involves absorption of photons being in the mitochondria of cells leading to improvement in electron transport, increased mitochondrial membrane potential (MMP), and greater ATP production. Low levels of reactive oxygen species (ROS) are produced by LLLT in normal cells that are beneficial. We exposed primary cultured murine cortical neurons to oxidative stressors: hydrogen peroxide, cobalt chloride and rotenone in the presence or absence of LLLT (3 J/cm², CW, 810 nm wavelength laser, 20 mW/cm²). Cell viability was determined by Prestoblue™ assay. ROS in mitochondria was detected using Mito-sox, while ROS in cytoplasm was detected with CellRox™. MMP was measured with tetramethylrhodamine. In normal neurons LLLT elevated MMP and increased ROS. In oxidatively-stressed cells LLLT increased MMP but reduced high ROS levels and protected cultured cortical neurons from death. Although LLLT increases ROS in normal neurons, it reduces ROS in oxidatively...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aeedd0636dcdedbb98d81066bc5d90a9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325593,"asset_id":30900191,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325593/download_file?st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900191"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900191; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900191]").text(description); $(".js-view-count[data-work-id=30900191]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900191; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900191']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900191, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aeedd0636dcdedbb98d81066bc5d90a9" } } $('.js-work-strip[data-work-id=30900191]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900191,"title":"Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro","translated_title":"","metadata":{"abstract":"Low-level laser (light) therapy (LLLT) involves absorption of photons being in the mitochondria of cells leading to improvement in electron transport, increased mitochondrial membrane potential (MMP), and greater ATP production. Low levels of reactive oxygen species (ROS) are produced by LLLT in normal cells that are beneficial. We exposed primary cultured murine cortical neurons to oxidative stressors: hydrogen peroxide, cobalt chloride and rotenone in the presence or absence of LLLT (3 J/cm², CW, 810 nm wavelength laser, 20 mW/cm²). Cell viability was determined by Prestoblue™ assay. ROS in mitochondria was detected using Mito-sox, while ROS in cytoplasm was detected with CellRox™. MMP was measured with tetramethylrhodamine. In normal neurons LLLT elevated MMP and increased ROS. In oxidatively-stressed cells LLLT increased MMP but reduced high ROS levels and protected cultured cortical neurons from death. Although LLLT increases ROS in normal neurons, it reduces ROS in oxidatively...","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of biophotonics"},"translated_abstract":"Low-level laser (light) therapy (LLLT) involves absorption of photons being in the mitochondria of cells leading to improvement in electron transport, increased mitochondrial membrane potential (MMP), and greater ATP production. Low levels of reactive oxygen species (ROS) are produced by LLLT in normal cells that are beneficial. We exposed primary cultured murine cortical neurons to oxidative stressors: hydrogen peroxide, cobalt chloride and rotenone in the presence or absence of LLLT (3 J/cm², CW, 810 nm wavelength laser, 20 mW/cm²). Cell viability was determined by Prestoblue™ assay. ROS in mitochondria was detected using Mito-sox, while ROS in cytoplasm was detected with CellRox™. MMP was measured with tetramethylrhodamine. 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a6a8d3ff696b7c8cf83da628ed7d4962" } } $('.js-work-strip[data-work-id=30900182]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900182,"title":"Evaluation of Chitosan-Tripolyphosphate Nanoparticles as a p-shRNA Delivery Vector: Formulation, Optimization and Cellular Uptake Study","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of Nanopharmaceutics and Drug Delivery"},"translated_abstract":null,"internal_url":"https://www.academia.edu/30900182/Evaluation_of_Chitosan_Tripolyphosphate_Nanoparticles_as_a_p_shRNA_Delivery_Vector_Formulation_Optimization_and_Cellular_Uptake_Study","translated_internal_url":"","created_at":"2017-01-12T15:25:33.217-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44782898,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":51325586,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51325586/thumbnails/1.jpg","file_name":"Evaluation_of_Chitosan-Tripolyphosphate_20170112-15978-1il6xfv.pdf","download_url":"https://www.academia.edu/attachments/51325586/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluation_of_Chitosan_Tripolyphosphate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51325586/Evaluation_of_Chitosan-Tripolyphosphate_20170112-15978-1il6xfv-libre.pdf?1484264029=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_Chitosan_Tripolyphosphate.pdf\u0026Expires=1732727687\u0026Signature=Iqnusjt3gjzwlJBGlAXKrvB7KelWJP5kSglFtMRHAhe-Fn1FvyTXx1v1RcXeHjH9XdKSV1kVqWoGmtFCIyDjHHPEmSyLHOAth8Lp43xzNbXOkWs1Ij8eDEOs-qiSXZxgSVvv9XnasWTpD-XiFHCSpDRW-LINrF3Zdk6d8muRpInWbPbQTBleK-a-LbzgxeUGcxS5pOL~~PdaGNrREitfjqdrcV7AnG0boN2eM9CZbbyJdi3aYW67HfpUO-qVDrodRcobAbWauWOs-KkvYfUF7Qv66~r7LgtrLUxvDiMp6bfWDRjdVpMzAgPT2dlzmQB-KfwnAQKdDDP7nOpHe~1m3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evaluation_of_Chitosan_Tripolyphosphate_Nanoparticles_as_a_p_shRNA_Delivery_Vector_Formulation_Optimization_and_Cellular_Uptake_Study","translated_slug":"","page_count":15,"language":"en","content_type":"Work","owner":{"id":44782898,"first_name":"Mike","middle_initials":null,"last_name":"Hamblin","page_name":"MikeHamblin","domain_name":"hms-harvard","created_at":"2016-03-09T09:35:44.332-08:00","display_name":"Mike Hamblin","url":"https://hms-harvard.academia.edu/MikeHamblin"},"attachments":[{"id":51325586,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51325586/thumbnails/1.jpg","file_name":"Evaluation_of_Chitosan-Tripolyphosphate_20170112-15978-1il6xfv.pdf","download_url":"https://www.academia.edu/attachments/51325586/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluation_of_Chitosan_Tripolyphosphate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51325586/Evaluation_of_Chitosan-Tripolyphosphate_20170112-15978-1il6xfv-libre.pdf?1484264029=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_Chitosan_Tripolyphosphate.pdf\u0026Expires=1732727687\u0026Signature=Iqnusjt3gjzwlJBGlAXKrvB7KelWJP5kSglFtMRHAhe-Fn1FvyTXx1v1RcXeHjH9XdKSV1kVqWoGmtFCIyDjHHPEmSyLHOAth8Lp43xzNbXOkWs1Ij8eDEOs-qiSXZxgSVvv9XnasWTpD-XiFHCSpDRW-LINrF3Zdk6d8muRpInWbPbQTBleK-a-LbzgxeUGcxS5pOL~~PdaGNrREitfjqdrcV7AnG0boN2eM9CZbbyJdi3aYW67HfpUO-qVDrodRcobAbWauWOs-KkvYfUF7Qv66~r7LgtrLUxvDiMp6bfWDRjdVpMzAgPT2dlzmQB-KfwnAQKdDDP7nOpHe~1m3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900181"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900181/Low_level_laser_light_therapy_LLLT_on_muscle_tissue_performance_fatigue_and_repair_benefited_by_the_power_of_light"><img alt="Research paper thumbnail of Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light" class="work-thumbnail" src="https://attachments.academia-assets.com/51325581/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900181/Low_level_laser_light_therapy_LLLT_on_muscle_tissue_performance_fatigue_and_repair_benefited_by_the_power_of_light">Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4bf0d8e16fe8f645c8f2a69c1d8a10cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325581,"asset_id":30900181,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325581/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900181"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900181"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900181; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900181]").text(description); $(".js-view-count[data-work-id=30900181]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900181; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900181']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900181, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4790104" id="papers"><div class="js-work-strip profile--work_container" data-work-id="30900199"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900199/Wound_Healing_Properties_of_Chitosan_and_Its_Use_in_Wound_Dressing_Biopharmaceuticals"><img alt="Research paper thumbnail of Wound-Healing Properties of Chitosan and Its Use in Wound Dressing Biopharmaceuticals" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900199/Wound_Healing_Properties_of_Chitosan_and_Its_Use_in_Wound_Dressing_Biopharmaceuticals">Wound-Healing Properties of Chitosan and Its Use in Wound Dressing Biopharmaceuticals</a></div><div class="wp-workCard_item"><span>Delivery, Targeting and Polymer Therapeutics</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT This chapter contains sections titled: IntroductionBrief Review of Wound RepairWound-Hea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT This chapter contains sections titled: IntroductionBrief Review of Wound RepairWound-Healing Effects of ChitosanChitosan for Wound Therapeutics DeliveryConclusions and Future PerspectivesAcknowledgmentsReferences</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900199"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900199"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900199; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900198"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900198/Biodistribution_of_charged_F_ab_2_photoimmunoconjugates_in_a_xenograft_model_of_ovarian_cancer"><img alt="Research paper thumbnail of Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/51325591/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900198/Biodistribution_of_charged_F_ab_2_photoimmunoconjugates_in_a_xenograft_model_of_ovarian_cancer">Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer</a></div><div class="wp-workCard_item"><span>British journal of cancer</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a x...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorin(e6)c(e6) was attached site specifically to the F(ab&#39;)2 fragment of the murine monoclonal antibody OC125, directed against human ovarian cancer cells, via poly-1-lysine linkers carrying cationic or anionic charges. Preservation of immunoreactivity was checked by enzyme-linked immunosorbent assay (ELISA). PICs were radiolabelled with 125I and compared with non-specific rabbit IgG PICs after intraperitoneal (i.p.) injection into nude mice. Samples were taken from normal organs and tumour at 3 h and 24 h. Tumour to normal 125I ratios showed that the cationic OC125F(ab&#39;)2 PIC had the highest tumour selectivity. Ratios for c(e6) were uniformly higher than for 125I, indicating that c(e6) became separated from 125I. 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Chlorin(e6)c(e6) was attached site specifically to the F(ab\u0026#39;)2 fragment of the murine monoclonal antibody OC125, directed against human ovarian cancer cells, via poly-1-lysine linkers carrying cationic or anionic charges. Preservation of immunoreactivity was checked by enzyme-linked immunosorbent assay (ELISA). PICs were radiolabelled with 125I and compared with non-specific rabbit IgG PICs after intraperitoneal (i.p.) injection into nude mice. Samples were taken from normal organs and tumour at 3 h and 24 h. Tumour to normal 125I ratios showed that the cationic OC125F(ab\u0026#39;)2 PIC had the highest tumour selectivity. Ratios for c(e6) were uniformly higher than for 125I, indicating that c(e6) became separated from 125I. OC125F(ab\u0026#39;)2 gave highest tissue values of 125I, followed by cationic OC125F(ab\u0026#39;)2 PIC; other species were ...","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"British journal of cancer"},"translated_abstract":"The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorin(e6)c(e6) was attached site specifically to the F(ab\u0026#39;)2 fragment of the murine monoclonal antibody OC125, directed against human ovarian cancer cells, via poly-1-lysine linkers carrying cationic or anionic charges. Preservation of immunoreactivity was checked by enzyme-linked immunosorbent assay (ELISA). PICs were radiolabelled with 125I and compared with non-specific rabbit IgG PICs after intraperitoneal (i.p.) injection into nude mice. Samples were taken from normal organs and tumour at 3 h and 24 h. Tumour to normal 125I ratios showed that the cationic OC125F(ab\u0026#39;)2 PIC had the highest tumour selectivity. Ratios for c(e6) were uniformly higher than for 125I, indicating that c(e6) became separated from 125I. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900197"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900197/Photodynamic_therapy_plus_regulatory_T_cell_depletion_produces_immunity_against_a_mouse_tumour_that_expresses_a_self_antigen"><img alt="Research paper thumbnail of Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen" class="work-thumbnail" src="https://attachments.academia-assets.com/51325589/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900197/Photodynamic_therapy_plus_regulatory_T_cell_depletion_produces_immunity_against_a_mouse_tumour_that_expresses_a_self_antigen">Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen</a></div><div class="wp-workCard_item"><span>British journal of cancer</span><span>, Jan 15, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-me...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-mediated immunity can be potentiated by T regulatory cell (Treg) depletion. We investigated whether the combination of PDT with cyclophosphamide (CY) could foster immunity against wild-type tumours expressing self-antigen (gp70). Mice with CT26 tumours were treated with PDT alone or in combination with low-dose CY. T regulatory cell numbers and transforming growth factor-β (TGF-β) levels were measured at several time points after treatment. Mice cured by PDT+CY were rechallenged with CT26 and monitored for long-term survival. Photodynamic therapy+CY led to complete tumour regression and long-term survival in 90% of treated mice while the absolute numbers of Treg decreased after PDT+CY and the TGF-β levels were reduced to a level comparable to naïve mice. Sixty-five percent of the mice treated with PDT+CY that survived over 90 days tumour free rejected the rechallenge with the same tumour w...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5a92d2b0d7ce09c4c20247bcffbc815b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325589,"asset_id":30900197,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325589/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900197"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900197"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900197; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900197]").text(description); $(".js-view-count[data-work-id=30900197]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900197; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900197']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900197, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5a92d2b0d7ce09c4c20247bcffbc815b" } } $('.js-work-strip[data-work-id=30900197]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900197,"title":"Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen","translated_title":"","metadata":{"abstract":"Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-mediated immunity can be potentiated by T regulatory cell (Treg) depletion. We investigated whether the combination of PDT with cyclophosphamide (CY) could foster immunity against wild-type tumours expressing self-antigen (gp70). Mice with CT26 tumours were treated with PDT alone or in combination with low-dose CY. T regulatory cell numbers and transforming growth factor-β (TGF-β) levels were measured at several time points after treatment. Mice cured by PDT+CY were rechallenged with CT26 and monitored for long-term survival. Photodynamic therapy+CY led to complete tumour regression and long-term survival in 90% of treated mice while the absolute numbers of Treg decreased after PDT+CY and the TGF-β levels were reduced to a level comparable to naïve mice. Sixty-five percent of the mice treated with PDT+CY that survived over 90 days tumour free rejected the rechallenge with the same tumour w...","publication_date":{"day":15,"month":1,"year":2013,"errors":{}},"publication_name":"British journal of cancer"},"translated_abstract":"Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-mediated immunity can be potentiated by T regulatory cell (Treg) depletion. We investigated whether the combination of PDT with cyclophosphamide (CY) could foster immunity against wild-type tumours expressing self-antigen (gp70). Mice with CT26 tumours were treated with PDT alone or in combination with low-dose CY. T regulatory cell numbers and transforming growth factor-β (TGF-β) levels were measured at several time points after treatment. Mice cured by PDT+CY were rechallenged with CT26 and monitored for long-term survival. Photodynamic therapy+CY led to complete tumour regression and long-term survival in 90% of treated mice while the absolute numbers of Treg decreased after PDT+CY and the TGF-β levels were reduced to a level comparable to naïve mice. Sixty-five percent of the mice treated with PDT+CY that survived over 90 days tumour free rejected the rechallenge with the same tumour w...","internal_url":"https://www.academia.edu/30900197/Photodynamic_therapy_plus_regulatory_T_cell_depletion_produces_immunity_against_a_mouse_tumour_that_expresses_a_self_antigen","translated_internal_url":"","created_at":"2017-01-12T15:25:38.261-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44782898,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":51325589,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51325589/thumbnails/1.jpg","file_name":"Photodynamic_therapy_plus_regulatory_T-c20170112-15972-bni1it.pdf","download_url":"https://www.academia.edu/attachments/51325589/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Photodynamic_therapy_plus_regulatory_T_c.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51325589/Photodynamic_therapy_plus_regulatory_T-c20170112-15972-bni1it-libre.pdf?1484264031=\u0026response-content-disposition=attachment%3B+filename%3DPhotodynamic_therapy_plus_regulatory_T_c.pdf\u0026Expires=1732727687\u0026Signature=JWyeUecqOvqN4Fg4qWZ9dnlZFmcZFZrA3gcRRIunZ0VP2YOZrlRJNl30l5v~8N0M5qNrRsJWckyD8t2tEMXu6Lo~S6uwBRBhvphXOMFCx4ECydOsh2w1A3Ku9~6t-542bjww-44CcEEjt9YFrkR9q7CNZjNI6re2iEE1PIm6KHoQ7MWnakbuzZLbcClQaAqF5s5tB8F3MaAPtVi1n18xi-SJpZGbOxSYtvi-xND4WY5RGARA1K7k3xepq80Sl82gcQWZn-elq7dez3yWABjnio7AbqZ97dwgxxfkDrojP4bmkPkquSzHYCvufxrV7pSreT71O4yAKmEwGUeFFRMKNA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Photodynamic_therapy_plus_regulatory_T_cell_depletion_produces_immunity_against_a_mouse_tumour_that_expresses_a_self_antigen","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":44782898,"first_name":"Mike","middle_initials":null,"last_name":"Hamblin","page_name":"MikeHamblin","domain_name":"hms-harvard","created_at":"2016-03-09T09:35:44.332-08:00","display_name":"Mike Hamblin","url":"https://hms-harvard.academia.edu/MikeHamblin"},"attachments":[{"id":51325589,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51325589/thumbnails/1.jpg","file_name":"Photodynamic_therapy_plus_regulatory_T-c20170112-15972-bni1it.pdf","download_url":"https://www.academia.edu/attachments/51325589/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Photodynamic_therapy_plus_regulatory_T_c.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51325589/Photodynamic_therapy_plus_regulatory_T-c20170112-15972-bni1it-libre.pdf?1484264031=\u0026response-content-disposition=attachment%3B+filename%3DPhotodynamic_therapy_plus_regulatory_T_c.pdf\u0026Expires=1732727687\u0026Signature=JWyeUecqOvqN4Fg4qWZ9dnlZFmcZFZrA3gcRRIunZ0VP2YOZrlRJNl30l5v~8N0M5qNrRsJWckyD8t2tEMXu6Lo~S6uwBRBhvphXOMFCx4ECydOsh2w1A3Ku9~6t-542bjww-44CcEEjt9YFrkR9q7CNZjNI6re2iEE1PIm6KHoQ7MWnakbuzZLbcClQaAqF5s5tB8F3MaAPtVi1n18xi-SJpZGbOxSYtvi-xND4WY5RGARA1K7k3xepq80Sl82gcQWZn-elq7dez3yWABjnio7AbqZ97dwgxxfkDrojP4bmkPkquSzHYCvufxrV7pSreT71O4yAKmEwGUeFFRMKNA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":375077,"name":"Photochemotherapy","url":"https://www.academia.edu/Documents/in/Photochemotherapy"},{"id":527900,"name":"Transforming Growth Factor Beta","url":"https://www.academia.edu/Documents/in/Transforming_Growth_Factor_Beta"},{"id":1198588,"name":"Cyclophosphamide","url":"https://www.academia.edu/Documents/in/Cyclophosphamide"},{"id":1864827,"name":"Autoantigens","url":"https://www.academia.edu/Documents/in/Autoantigens"},{"id":2079216,"name":"Lymph nodes","url":"https://www.academia.edu/Documents/in/Lymph_nodes"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900196"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900196/Targeted_photodestruction_of_human_colon_cancer_cells_using_charged_17_1A_chlorin_e6_immunoconjugates"><img alt="Research paper thumbnail of Targeted photodestruction of human colon cancer cells using charged 17.1A chlorin e6 immunoconjugates" class="work-thumbnail" src="https://attachments.academia-assets.com/51325588/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900196/Targeted_photodestruction_of_human_colon_cancer_cells_using_charged_17_1A_chlorin_e6_immunoconjugates">Targeted photodestruction of human colon cancer cells using charged 17.1A chlorin e6 immunoconjugates</a></div><div class="wp-workCard_item"><span>British journal of cancer</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The goal of this study was to develop a strategy for the selective destruction of colorectal canc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The goal of this study was to develop a strategy for the selective destruction of colorectal cancer cells. Towards this end, photoimmunoconjugates were prepared between the anti-colon cancer monoclonal antibody 17.1A and the photosensitizer (PS) chlorin(e6) (c(e6)). Polylysine linkers bearing several c(e6) molecules were covalently attached in a site-specific manner to partially reduced IgG molecules, which allowed photoimmunoconjugates to bear either cationic or anionic charges. The conjugates retained immunoreactivity as shown by enzyme-linked immunosorbent assays and by competition studies with native antibody. The overall charge on the photoimmunoconjugate was an important determinant of PS delivery. The cationic photoimmunoconjugate delivered 4 times more c(e6) to the cells than the anionic photoimmunoconjugate, and both 17.1A conjugates showed, in comparison to non-specific rabbit IgG conjugates, selectivity for antigen-positive target cells. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900195"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900195/Photodynamic_therapy_of_orthotopic_prostate_cancer_with_benzoporphyrin_derivative_local_control_and_distant_metastasis"><img alt="Research paper thumbnail of Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis" class="work-thumbnail" src="https://attachments.academia-assets.com/51325590/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900195/Photodynamic_therapy_of_orthotopic_prostate_cancer_with_benzoporphyrin_derivative_local_control_and_distant_metastasis">Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is the first report of photodynamic therapy (PDT) in an orthotopic prostate tumor model and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is the first report of photodynamic therapy (PDT) in an orthotopic prostate tumor model and shows that PDT combined with surgery (tumor bed sterilization) gave significant local control of the primary tumor and significant reduction in distant metastases. By contrast, either treatment alone (surgery or PDT) gave relatively poorer local control, and PDT gave a significant increase in the mean number of lung metastases. The MatLyLu variant of the Dunning 3327 rat prostate cancer cell line, which has been selected to be metastatic to lymph nodes and lungs, was injected into the ventral lobe of the rat prostate. After 7 days, tumors were either treated by surgical removal of the ventral lobe, PDT with liposomal benzoporphyrin derivative monoacid ring A, or a combination of surgery, followed by PDT of the tumor bed. Results after 21 days showed a reduction in prostate tumor weight in all groups compared with controls, which became highly significant only for the combination group (1...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="336a8de4df568f6e0b6130cfb0c8fb80" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325590,"asset_id":30900195,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325590/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900195"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900195"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900195; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900195]").text(description); $(".js-view-count[data-work-id=30900195]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900195; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900195']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900195, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "336a8de4df568f6e0b6130cfb0c8fb80" } } $('.js-work-strip[data-work-id=30900195]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900195,"title":"Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis","translated_title":"","metadata":{"abstract":"This is the first report of photodynamic therapy (PDT) in an orthotopic prostate tumor model and shows that PDT combined with surgery (tumor bed sterilization) gave significant local control of the primary tumor and significant reduction in distant metastases. 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After 7 days, tumors were either treated by surgical removal of the ventral lobe, PDT with liposomal benzoporphyrin derivative monoacid ring A, or a combination of surgery, followed by PDT of the tumor bed. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900194/Effect_of_charge_on_the_interaction_of_site_specific_photoimmunoconjugates_with_human_ovarian_cancer_cells"><img alt="Research paper thumbnail of Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells" class="work-thumbnail" src="https://attachments.academia-assets.com/51325594/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900194/Effect_of_charge_on_the_interaction_of_site_specific_photoimmunoconjugates_with_human_ovarian_cancer_cells">Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, Jan 15, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate (PIC) was demonstrated. A site-specific conjugation strategy was developed to attach the photosensitizer chlorin(e6) (c(e6)) to the F(ab&#39;)2 fragment of the murine antiovarian cancer monoclonal antibody OC125. Poly-L-lysine linkers carrying c(e6) with a cationic charge or by polysuccinylation with an anionic charge were used and covalently attached to partially reduced antibody via a heterobifunctional reagent. PICs were purified by column chromatography and were also radiolabeled with 125I. PIC binding and uptake were studied with a human ovarian cancer cell line, NIH-OVCAR-5, and a nonantigen-expressing colon cancer cell line, SW1116, and the data were compared with the binding and uptake of nonspecific rabbit IgG PICs. PICs with both cationic and anionic charges preserved antigen binding as shown by competition studies with native antibody, but the cationic PIC had up to 17 times h...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d00915fde99c3147f05289f791280f08" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325594,"asset_id":30900194,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325594/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900194]").text(description); $(".js-view-count[data-work-id=30900194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900194, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d00915fde99c3147f05289f791280f08" } } $('.js-work-strip[data-work-id=30900194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900194,"title":"Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells","translated_title":"","metadata":{"abstract":"A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate (PIC) was demonstrated. A site-specific conjugation strategy was developed to attach the photosensitizer chlorin(e6) (c(e6)) to the F(ab\u0026#39;)2 fragment of the murine antiovarian cancer monoclonal antibody OC125. Poly-L-lysine linkers carrying c(e6) with a cationic charge or by polysuccinylation with an anionic charge were used and covalently attached to partially reduced antibody via a heterobifunctional reagent. PICs were purified by column chromatography and were also radiolabeled with 125I. PIC binding and uptake were studied with a human ovarian cancer cell line, NIH-OVCAR-5, and a nonantigen-expressing colon cancer cell line, SW1116, and the data were compared with the binding and uptake of nonspecific rabbit IgG PICs. PICs with both cationic and anionic charges preserved antigen binding as shown by competition studies with native antibody, but the cationic PIC had up to 17 times h...","publication_date":{"day":15,"month":1,"year":1996,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate (PIC) was demonstrated. A site-specific conjugation strategy was developed to attach the photosensitizer chlorin(e6) (c(e6)) to the F(ab\u0026#39;)2 fragment of the murine antiovarian cancer monoclonal antibody OC125. Poly-L-lysine linkers carrying c(e6) with a cationic charge or by polysuccinylation with an anionic charge were used and covalently attached to partially reduced antibody via a heterobifunctional reagent. PICs were purified by column chromatography and were also radiolabeled with 125I. PIC binding and uptake were studied with a human ovarian cancer cell line, NIH-OVCAR-5, and a nonantigen-expressing colon cancer cell line, SW1116, and the data were compared with the binding and uptake of nonspecific rabbit IgG PICs. PICs with both cationic and anionic charges preserved antigen binding as shown by competition studies with native antibody, but the cationic PIC had up to 17 times h...","internal_url":"https://www.academia.edu/30900194/Effect_of_charge_on_the_interaction_of_site_specific_photoimmunoconjugates_with_human_ovarian_cancer_cells","translated_internal_url":"","created_at":"2017-01-12T15:25:37.317-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44782898,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":51325594,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51325594/thumbnails/1.jpg","file_name":"5205.full.pdf","download_url":"https://www.academia.edu/attachments/51325594/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_charge_on_the_interaction_of_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51325594/5205.full-libre.pdf?1484264030=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_charge_on_the_interaction_of_s.pdf\u0026Expires=1732727687\u0026Signature=JxMkZbjxj-tEqbutuZqmCIbug8DlBxDeaZW1yaI0sv8OUuF~iik4GztSa4vCocfb8sVE4Gth6UV~zCW4bjDuD5tM54sbRVCTiqMghQkFNYIUBamJKqHTXquh8HIaO9xMxvuKZrsdkL-uvc6IJn0iEMKLavZNGfMHkS74XQd~aEgOECp5kBxGr81Ca2YDjlD9quALH8b0ZQ5CkgU89hPP0O-m~lo4tBmmk6BgxEXC0D8u4LJ~J4l~v5G3drTB~ulYHFtrXzx~jvmjia4bDbTq6B6E8-Wt1elf7YvyFl5z5cwH12tm53pRHANKsYFAANhwpFR9NEzbtT7oV3upTNSe9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_of_charge_on_the_interaction_of_site_specific_photoimmunoconjugates_with_human_ovarian_cancer_cells","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":44782898,"first_name":"Mike","middle_initials":null,"last_name":"Hamblin","page_name":"MikeHamblin","domain_name":"hms-harvard","created_at":"2016-03-09T09:35:44.332-08:00","display_name":"Mike Hamblin","url":"https://hms-harvard.academia.edu/MikeHamblin"},"attachments":[{"id":51325594,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51325594/thumbnails/1.jpg","file_name":"5205.full.pdf","download_url":"https://www.academia.edu/attachments/51325594/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_charge_on_the_interaction_of_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51325594/5205.full-libre.pdf?1484264030=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_charge_on_the_interaction_of_s.pdf\u0026Expires=1732727687\u0026Signature=JxMkZbjxj-tEqbutuZqmCIbug8DlBxDeaZW1yaI0sv8OUuF~iik4GztSa4vCocfb8sVE4Gth6UV~zCW4bjDuD5tM54sbRVCTiqMghQkFNYIUBamJKqHTXquh8HIaO9xMxvuKZrsdkL-uvc6IJn0iEMKLavZNGfMHkS74XQd~aEgOECp5kBxGr81Ca2YDjlD9quALH8b0ZQ5CkgU89hPP0O-m~lo4tBmmk6BgxEXC0D8u4LJ~J4l~v5G3drTB~ulYHFtrXzx~jvmjia4bDbTq6B6E8-Wt1elf7YvyFl5z5cwH12tm53pRHANKsYFAANhwpFR9NEzbtT7oV3upTNSe9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7700,"name":"Fluorescence Microscopy","url":"https://www.academia.edu/Documents/in/Fluorescence_Microscopy"},{"id":51613,"name":"Internalization","url":"https://www.academia.edu/Documents/in/Internalization"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":133177,"name":"Temperature","url":"https://www.academia.edu/Documents/in/Temperature"},{"id":869175,"name":"Ovary","url":"https://www.academia.edu/Documents/in/Ovary"},{"id":1013858,"name":"Cations","url":"https://www.academia.edu/Documents/in/Cations"},{"id":1371571,"name":"Internalisation","url":"https://www.academia.edu/Documents/in/Internalisation"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900193"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900193/myo_Inositol_phosphorothioates_phosphatase_resistant_analogues_of_myo_inositol_phosphates_Synthesis_of_DL_myo_inositol_1_4_bisphosphate_and_DL_myo_inositol_1_4_bisphosphorothioate"><img alt="Research paper thumbnail of myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of DL-myo-inositol 1,4-bisphosphate and DL-myo-inositol 1,4-bisphosphorothioate" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900193/myo_Inositol_phosphorothioates_phosphatase_resistant_analogues_of_myo_inositol_phosphates_Synthesis_of_DL_myo_inositol_1_4_bisphosphate_and_DL_myo_inositol_1_4_bisphosphorothioate">myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of DL-myo-inositol 1,4-bisphosphate and DL-myo-inositol 1,4-bisphosphorothioate</a></div><div class="wp-workCard_item"><span>The Biochemical journal</span><span>, Jan 15, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol 1,4-bisphosphate, and an analogue, the 1,4-bisphosphorothioate, are reported, by using phosphite chemistry on (+/-)-1,2:4,5-di-isopropylidene-myo-inositol. The synthesis of (+/-)-1,2:4,5-di-isopropylidene 3,6-bis[di-(2-cyanoethyl)]phosphite provides an intermediate that can be oxidized to either the corresponding bisphosphate or bisphosphorothioate. myo-Inositol phosphorothioates are proposed as novel analogues of myo-inositol phosphates; their resistance to phosphatase-catalysed breakdown is reported.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900193"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900193"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900193; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900193]").text(description); $(".js-view-count[data-work-id=30900193]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900193; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900193']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900193, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30900193]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900193,"title":"myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of DL-myo-inositol 1,4-bisphosphate and DL-myo-inositol 1,4-bisphosphorothioate","translated_title":"","metadata":{"abstract":"Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol 1,4-bisphosphate, and an analogue, the 1,4-bisphosphorothioate, are reported, by using phosphite chemistry on (+/-)-1,2:4,5-di-isopropylidene-myo-inositol. The synthesis of (+/-)-1,2:4,5-di-isopropylidene 3,6-bis[di-(2-cyanoethyl)]phosphite provides an intermediate that can be oxidized to either the corresponding bisphosphate or bisphosphorothioate. myo-Inositol phosphorothioates are proposed as novel analogues of myo-inositol phosphates; their resistance to phosphatase-catalysed breakdown is reported.","publication_date":{"day":15,"month":1,"year":1987,"errors":{}},"publication_name":"The Biochemical journal"},"translated_abstract":"Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol 1,4-bisphosphate, and an analogue, the 1,4-bisphosphorothioate, are reported, by using phosphite chemistry on (+/-)-1,2:4,5-di-isopropylidene-myo-inositol. The synthesis of (+/-)-1,2:4,5-di-isopropylidene 3,6-bis[di-(2-cyanoethyl)]phosphite provides an intermediate that can be oxidized to either the corresponding bisphosphate or bisphosphorothioate. myo-Inositol phosphorothioates are proposed as novel analogues of myo-inositol phosphates; their resistance to phosphatase-catalysed breakdown is reported.","internal_url":"https://www.academia.edu/30900193/myo_Inositol_phosphorothioates_phosphatase_resistant_analogues_of_myo_inositol_phosphates_Synthesis_of_DL_myo_inositol_1_4_bisphosphate_and_DL_myo_inositol_1_4_bisphosphorothioate","translated_internal_url":"","created_at":"2017-01-12T15:25:36.969-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44782898,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"myo_Inositol_phosphorothioates_phosphatase_resistant_analogues_of_myo_inositol_phosphates_Synthesis_of_DL_myo_inositol_1_4_bisphosphate_and_DL_myo_inositol_1_4_bisphosphorothioate","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44782898,"first_name":"Mike","middle_initials":null,"last_name":"Hamblin","page_name":"MikeHamblin","domain_name":"hms-harvard","created_at":"2016-03-09T09:35:44.332-08:00","display_name":"Mike Hamblin","url":"https://hms-harvard.academia.edu/MikeHamblin"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":176525,"name":"Biochemical","url":"https://www.academia.edu/Documents/in/Biochemical"},{"id":204435,"name":"Alkaline phosphatase","url":"https://www.academia.edu/Documents/in/Alkaline_phosphatase"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":2586983,"name":"Inositol Phosphates","url":"https://www.academia.edu/Documents/in/Inositol_Phosphates"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900192/Mung_bean_Phaseolus_aureus_nuclease_A_mechanistic_investigation_of_the_DNA_cleavage_reaction_using_a_dinucleoside_phosphorothioate"><img alt="Research paper thumbnail of Mung bean (Phaseolus aureus) nuclease. A mechanistic investigation of the DNA-cleavage reaction using a dinucleoside phosphorothioate" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900192/Mung_bean_Phaseolus_aureus_nuclease_A_mechanistic_investigation_of_the_DNA_cleavage_reaction_using_a_dinucleoside_phosphorothioate">Mung bean (Phaseolus aureus) nuclease. A mechanistic investigation of the DNA-cleavage reaction using a dinucleoside phosphorothioate</a></div><div class="wp-workCard_item"><span>The Biochemical journal</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mung-bean (Phaseolus aureus) nuclease has been found to cleave the Sp diastereoisomer of 5&#39;-O...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mung-bean (Phaseolus aureus) nuclease has been found to cleave the Sp diastereoisomer of 5&#39;-O-thymidyl 3&#39;-O-(2&#39;-deoxyadenosyl)phosphorothioate, (Sp)-d[Ap(S)T], in 18O-labelled water with inversion of configuration at phosphorus to give (Sp)-thymidine 5&#39;-[16O, 18O]phosphorothioate, the stereochemistry of which was deduced by methylation to (Rp,Sp)-thymidine 5&#39;-S-methyl-O-methyl-[16O,18O]phosphorothioate and 31P-n.m.r. analysis. This result is consistent with a mechanism involving a direct &#39;in-line&#39; attack of water on DNA for the nuclease-catalysed reaction without the involvement of a covalent nucleotidylated-enzyme intermediate.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900192]").text(description); $(".js-view-count[data-work-id=30900192]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900192; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900192']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900192, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30900192]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900192,"title":"Mung bean (Phaseolus aureus) nuclease. A mechanistic investigation of the DNA-cleavage reaction using a dinucleoside phosphorothioate","translated_title":"","metadata":{"abstract":"Mung-bean (Phaseolus aureus) nuclease has been found to cleave the Sp diastereoisomer of 5\u0026#39;-O-thymidyl 3\u0026#39;-O-(2\u0026#39;-deoxyadenosyl)phosphorothioate, (Sp)-d[Ap(S)T], in 18O-labelled water with inversion of configuration at phosphorus to give (Sp)-thymidine 5\u0026#39;-[16O, 18O]phosphorothioate, the stereochemistry of which was deduced by methylation to (Rp,Sp)-thymidine 5\u0026#39;-S-methyl-O-methyl-[16O,18O]phosphorothioate and 31P-n.m.r. analysis. This result is consistent with a mechanism involving a direct \u0026#39;in-line\u0026#39; attack of water on DNA for the nuclease-catalysed reaction without the involvement of a covalent nucleotidylated-enzyme intermediate.","publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"The Biochemical journal"},"translated_abstract":"Mung-bean (Phaseolus aureus) nuclease has been found to cleave the Sp diastereoisomer of 5\u0026#39;-O-thymidyl 3\u0026#39;-O-(2\u0026#39;-deoxyadenosyl)phosphorothioate, (Sp)-d[Ap(S)T], in 18O-labelled water with inversion of configuration at phosphorus to give (Sp)-thymidine 5\u0026#39;-[16O, 18O]phosphorothioate, the stereochemistry of which was deduced by methylation to (Rp,Sp)-thymidine 5\u0026#39;-S-methyl-O-methyl-[16O,18O]phosphorothioate and 31P-n.m.r. analysis. This result is consistent with a mechanism involving a direct \u0026#39;in-line\u0026#39; attack of water on DNA for the nuclease-catalysed reaction without the involvement of a covalent nucleotidylated-enzyme intermediate.","internal_url":"https://www.academia.edu/30900192/Mung_bean_Phaseolus_aureus_nuclease_A_mechanistic_investigation_of_the_DNA_cleavage_reaction_using_a_dinucleoside_phosphorothioate","translated_internal_url":"","created_at":"2017-01-12T15:25:36.605-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44782898,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Mung_bean_Phaseolus_aureus_nuclease_A_mechanistic_investigation_of_the_DNA_cleavage_reaction_using_a_dinucleoside_phosphorothioate","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44782898,"first_name":"Mike","middle_initials":null,"last_name":"Hamblin","page_name":"MikeHamblin","domain_name":"hms-harvard","created_at":"2016-03-09T09:35:44.332-08:00","display_name":"Mike Hamblin","url":"https://hms-harvard.academia.edu/MikeHamblin"},"attachments":[],"research_interests":[{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA"},{"id":87651,"name":"Methylation","url":"https://www.academia.edu/Documents/in/Methylation"},{"id":176525,"name":"Biochemical","url":"https://www.academia.edu/Documents/in/Biochemical"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":1030794,"name":"Hydrolysis","url":"https://www.academia.edu/Documents/in/Hydrolysis"},{"id":1362652,"name":"Nucleic Acid Conformation","url":"https://www.academia.edu/Documents/in/Nucleic_Acid_Conformation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30900191"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30900191/Low_level_laser_therapy_LLLT_reduces_oxidative_stress_in_primary_cortical_neurons_in_vitro"><img alt="Research paper thumbnail of Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/51325593/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30900191/Low_level_laser_therapy_LLLT_reduces_oxidative_stress_in_primary_cortical_neurons_in_vitro">Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro</a></div><div class="wp-workCard_item"><span>Journal of biophotonics</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Low-level laser (light) therapy (LLLT) involves absorption of photons being in the mitochondria o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Low-level laser (light) therapy (LLLT) involves absorption of photons being in the mitochondria of cells leading to improvement in electron transport, increased mitochondrial membrane potential (MMP), and greater ATP production. Low levels of reactive oxygen species (ROS) are produced by LLLT in normal cells that are beneficial. We exposed primary cultured murine cortical neurons to oxidative stressors: hydrogen peroxide, cobalt chloride and rotenone in the presence or absence of LLLT (3 J/cm², CW, 810 nm wavelength laser, 20 mW/cm²). Cell viability was determined by Prestoblue™ assay. ROS in mitochondria was detected using Mito-sox, while ROS in cytoplasm was detected with CellRox™. MMP was measured with tetramethylrhodamine. In normal neurons LLLT elevated MMP and increased ROS. In oxidatively-stressed cells LLLT increased MMP but reduced high ROS levels and protected cultured cortical neurons from death. Although LLLT increases ROS in normal neurons, it reduces ROS in oxidatively...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aeedd0636dcdedbb98d81066bc5d90a9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51325593,"asset_id":30900191,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51325593/download_file?st=MTczMjcyNDA4OCw4LjIyMi4yMDguMTQ2&st=MTczMjcyNDA4Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30900191"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30900191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30900191; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30900191]").text(description); $(".js-view-count[data-work-id=30900191]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30900191; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30900191']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30900191, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aeedd0636dcdedbb98d81066bc5d90a9" } } $('.js-work-strip[data-work-id=30900191]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30900191,"title":"Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro","translated_title":"","metadata":{"abstract":"Low-level laser (light) therapy (LLLT) involves absorption of photons being in the mitochondria of cells leading to improvement in electron transport, increased mitochondrial membrane potential (MMP), and greater ATP production. Low levels of reactive oxygen species (ROS) are produced by LLLT in normal cells that are beneficial. We exposed primary cultured murine cortical neurons to oxidative stressors: hydrogen peroxide, cobalt chloride and rotenone in the presence or absence of LLLT (3 J/cm², CW, 810 nm wavelength laser, 20 mW/cm²). Cell viability was determined by Prestoblue™ assay. ROS in mitochondria was detected using Mito-sox, while ROS in cytoplasm was detected with CellRox™. MMP was measured with tetramethylrhodamine. In normal neurons LLLT elevated MMP and increased ROS. In oxidatively-stressed cells LLLT increased MMP but reduced high ROS levels and protected cultured cortical neurons from death. Although LLLT increases ROS in normal neurons, it reduces ROS in oxidatively...","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of biophotonics"},"translated_abstract":"Low-level laser (light) therapy (LLLT) involves absorption of photons being in the mitochondria of cells leading to improvement in electron transport, increased mitochondrial membrane potential (MMP), and greater ATP production. Low levels of reactive oxygen species (ROS) are produced by LLLT in normal cells that are beneficial. We exposed primary cultured murine cortical neurons to oxidative stressors: hydrogen peroxide, cobalt chloride and rotenone in the presence or absence of LLLT (3 J/cm², CW, 810 nm wavelength laser, 20 mW/cm²). Cell viability was determined by Prestoblue™ assay. ROS in mitochondria was detected using Mito-sox, while ROS in cytoplasm was detected with CellRox™. MMP was measured with tetramethylrhodamine. 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One of these novel application areas is LLLT for muscle fatigue and muscle injury. Since it is becoming agreed that mitochondria are the principal photoacceptors present inside cells, and it is known that muscle cells are exceptionally rich in mitochondria, this suggests that LLLT should be highly beneficial in muscle injuries. The ability of LLLT to stimulate stem cells and progenitor cells means that muscle satellite cells may respond well to LLLT and help muscle repair. Furthermore the ability of LLLT to reduce inflammation and lessen oxidative stress is also beneficial in cases of muscle fatigue and injury. This review covers the literature relating to LLLT and muscles in both preclinical animal experiments and human clinical studies. 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