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class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72395558/In_vivo_estrogenic_like_activities_of_Gouania_longipetala_Hemsl_Rhamnaceae_bark_extracts_in_a_post_menopause_like_model_of_ovariectomized_Wistar_rats">In vivo estrogenic-like activities of Gouania longipetala Hemsl. (Rhamnaceae) bark extracts in a post-menopause-like model of ovariectomized Wistar rats</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Gouania longipetala is commonly used in Cameroonian traditional medicine to manage women fertility and menopausal complaints. However, despite this use, the estrogenic properties of Gouania longipetala (G. longipetala) have not been... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72395558" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Gouania longipetala is commonly used in Cameroonian traditional medicine to manage women fertility and menopausal complaints. However, despite this use, the estrogenic properties of Gouania longipetala (G. longipetala) have not been studied until now. The present study was aimed to assess estrogenic activities of the stem bark aqueous (GLA) and ethanolic (GLE) extracts of G. longipetala in post menopause-like model of ovariectomized (Ovx) Wistar rats. Animals were either sham-operated or Ovx. 84 days after ovariectomy, animals were divided into seven groups of five animals and were daily treated for 28 days with distilled water (10mL/kg) for group 1, 2% solution of Tween 80 (10mL/kg) for group 2, estradiol valerate (1mg/kg) for group 3, GLA (45 or 180mg/kg) and GLE (40 or 160mg/kg) for groups 4 to 7 respectively. Sham-operated animals daily received distilled water (10mL/kg). During the experimental period, the body weight was registered every week. At the day 29, blood pressure was registered by invasive method while uterine and vagina morphometry as well as body, uterine and abdominal fat weights changes were analyzed. Serum levels of total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were determined. Moreover, oxidative stress markers such as nitrites, reduced glutathione (GSH) and malondialdehyde (MDA) were measured in homogenized liver and aorta. Compared with the sham control, vagina and uterine dystrophy and elevated blood pressure were observed in Ovx rats treated with vehicles. Biochemical parameters showed a significant increase of total cholesterol, triglycerides, LDL-cholesterol and MDA as well as a significant decrease of nitrites and GSH in Ovx animals treated with vehicle as compared to sham group. GLA and GLE displayed estrogen-like effects on vagina and did not affect uterine wet weight and epithelial height compared with vehicle groups. Both extracts displayed anti-atherogenic properties by reducing AI, AIP and LDL-cholesterol level as compared to vehicles groups. GLA and GLE significantly prevented the increase of MDA induced by ovariectomy as compared to rats treated with vehicles. This study showed that GLA and GLE exhibited estrogenic effects by providing vaginal lubrication, by modulating blood pressure and improving lipid profile, oxidative status and endothelial function and may not have an undesirable influence on the endometrium in ovariectomized rats.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72395558" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="15099303" href="https://uyi-uninet.academia.edu/kameni_poumeni_mireille">Mireille Kameni</a><script data-card-contents-for-user="15099303" type="text/json">{"id":15099303,"first_name":"Mireille","last_name":"Kameni","domain_name":"uyi-uninet","page_name":"kameni_poumeni_mireille","display_name":"Mireille Kameni","profile_url":"https://uyi-uninet.academia.edu/kameni_poumeni_mireille?f_ri=90514","photo":"https://0.academia-photos.com/15099303/4073610/13514569/s65_mireille.kameni.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-72395558">+1</span><div class="hidden js-additional-users-72395558"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/DzeufietPaulDesire">Dzeufiet Paul Desire</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-72395558'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-72395558').html(); 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(Rhamnaceae) bark extracts in a post-menopause-like model of ovariectomized Wistar rats","created_at":"2022-02-24T02:56:21.770-08:00","url":"https://www.academia.edu/72395558/In_vivo_estrogenic_like_activities_of_Gouania_longipetala_Hemsl_Rhamnaceae_bark_extracts_in_a_post_menopause_like_model_of_ovariectomized_Wistar_rats?f_ri=90514","dom_id":"work_72395558","summary":"Gouania longipetala is commonly used in Cameroonian traditional medicine to manage women fertility and menopausal complaints. However, despite this use, the estrogenic properties of Gouania longipetala (G. longipetala) have not been studied until now. The present study was aimed to assess estrogenic activities of the stem bark aqueous (GLA) and ethanolic (GLE) extracts of G. longipetala in post menopause-like model of ovariectomized (Ovx) Wistar rats. Animals were either sham-operated or Ovx. 84 days after ovariectomy, animals were divided into seven groups of five animals and were daily treated for 28 days with distilled water (10mL/kg) for group 1, 2% solution of Tween 80 (10mL/kg) for group 2, estradiol valerate (1mg/kg) for group 3, GLA (45 or 180mg/kg) and GLE (40 or 160mg/kg) for groups 4 to 7 respectively. Sham-operated animals daily received distilled water (10mL/kg). During the experimental period, the body weight was registered every week. At the day 29, blood pressure was registered by invasive method while uterine and vagina morphometry as well as body, uterine and abdominal fat weights changes were analyzed. Serum levels of total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were determined. Moreover, oxidative stress markers such as nitrites, reduced glutathione (GSH) and malondialdehyde (MDA) were measured in homogenized liver and aorta. Compared with the sham control, vagina and uterine dystrophy and elevated blood pressure were observed in Ovx rats treated with vehicles. Biochemical parameters showed a significant increase of total cholesterol, triglycerides, LDL-cholesterol and MDA as well as a significant decrease of nitrites and GSH in Ovx animals treated with vehicle as compared to sham group. GLA and GLE displayed estrogen-like effects on vagina and did not affect uterine wet weight and epithelial height compared with vehicle groups. Both extracts displayed anti-atherogenic properties by reducing AI, AIP and LDL-cholesterol level as compared to vehicles groups. GLA and GLE significantly prevented the increase of MDA induced by ovariectomy as compared to rats treated with vehicles. This study showed that GLA and GLE exhibited estrogenic effects by providing vaginal lubrication, by modulating blood pressure and improving lipid profile, oxidative status and endothelial function and may not have an undesirable influence on the endometrium in ovariectomized rats.","downloadable_attachments":[],"ordered_authors":[{"id":15099303,"first_name":"Mireille","last_name":"Kameni","domain_name":"uyi-uninet","page_name":"kameni_poumeni_mireille","display_name":"Mireille Kameni","profile_url":"https://uyi-uninet.academia.edu/kameni_poumeni_mireille?f_ri=90514","photo":"https://0.academia-photos.com/15099303/4073610/13514569/s65_mireille.kameni.jpg"},{"id":50834665,"first_name":"Dzeufiet","last_name":"Paul Desire","domain_name":"independent","page_name":"DzeufietPaulDesire","display_name":"Dzeufiet Paul 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u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/71535971/Association_of_cholesterol_and_socio_demographic_parameters_with_suicidality_in_the_male_patients_with_schizophrenia">Association of cholesterol and socio-demographic parameters with suicidality in the male patients with schizophrenia</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/71535971" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b518f014a8a5d115a8a0b3d5c2dcd122" rel="nofollow" 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Martinac","profile_url":"https://sum-ba.academia.edu/MarkoMartinac?f_ri=90514","photo":"https://0.academia-photos.com/35933744/34826484/30449074/s65_marko.martinac.jpg"}],"research_interests":[{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia?f_ri=90514","nofollow":false},{"id":8981,"name":"Suicide","url":"https://www.academia.edu/Documents/in/Suicide?f_ri=90514","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=90514","nofollow":false},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=90514","nofollow":false},{"id":51565,"name":"Serotonin","url":"https://www.academia.edu/Documents/in/Serotonin?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":105232,"name":"Croatia","url":"https://www.academia.edu/Documents/in/Croatia?f_ri=90514"},{"id":110254,"name":"Alcohol 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Spicer","profile_url":"https://independent.academia.edu/SpicerL?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4630,"name":"Dairy Science","url":"https://www.academia.edu/Documents/in/Dairy_Science?f_ri=90514","nofollow":false},{"id":19826,"name":"Lactation","url":"https://www.academia.edu/Documents/in/Lactation?f_ri=90514","nofollow":false},{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production?f_ri=90514","nofollow":false},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism?f_ri=90514","nofollow":false},{"id":64559,"name":"Progesterone","url":"https://www.academia.edu/Documents/in/Progesterone?f_ri=90514"},{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose?f_ri=90514"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":98942,"name":"Ovulation","url":"https://www.academia.edu/Documents/in/Ovulation?f_ri=90514"},{"id":238368,"name":"Milk","url":"https://www.academia.edu/Documents/in/Milk?f_ri=90514"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle?f_ri=90514"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=90514"},{"id":573653,"name":"Food Sciences","url":"https://www.academia.edu/Documents/in/Food_Sciences?f_ri=90514"},{"id":781097,"name":"Lactose","url":"https://www.academia.edu/Documents/in/Lactose?f_ri=90514"},{"id":3067129,"name":"postpartum period","url":"https://www.academia.edu/Documents/in/postpartum_period?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70088582" data-work_id="70088582" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70088582/Intracellular_signaling_cascades_induced_by_relaxin_in_the_stimulation_of_capacitation_and_acrosome_reaction_in_fresh_and_frozen_thawed_bovine_spermatozoa">Intracellular signaling cascades induced by relaxin in the stimulation of capacitation and acrosome reaction in fresh and frozen-thawed bovine spermatozoa</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Relaxin is one of the 6-kDa peptide hormones, which acts as a pleiotropic endocrine and paracrine factor. Our previous studies revealed that sperm capacitating medium containing relaxin induced capacitation and acrosome reaction (AR) in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70088582" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Relaxin is one of the 6-kDa peptide hormones, which acts as a pleiotropic endocrine and paracrine factor. Our previous studies revealed that sperm capacitating medium containing relaxin induced capacitation and acrosome reaction (AR) in fresh and frozen-thawed porcine or bovine spermatozoa. However, the intracellular signaling cascades involved with capacitation or AR induced by relaxin was unknown. Therefore, the present study was designed to investigate the intracellular signaling cascades involved with capacitation and AR induced by relaxin in fresh and frozen-thawed bovine spermatozoa. Spermatozoa were incubated in sperm Tyrode&amp;#39;s albumin lactate pyruvate (Sp-TALP) medium supplemented with (40 ng ml(-1)) or without relaxin, and subjected to evaluation of chlortetracycline staining pattern, cholesterol efflux, Ca(2+)-influx, intracellular cyclic adenosine monophosphate (cAMP) and protein tyrosine phosphorylation. Capacitation and AR were increased (P&amp;lt;0.05) in both fresh and frozen-thawed spermatozoa incubated with relaxin. Cholesterol effluxes were greater in the fresh (P&amp;lt;0.01) and frozen-thawed (P&amp;lt;0.05) spermatozoa incubated with relaxin than the spermatozoa incubated without relaxin. Ca(2+)-influxes were also significantly stimulated by relaxin in the fresh (P&amp;lt;0.01) and frozen-thawed (P&amp;lt;0.05) spermatozoa. The Sp-TALP medium containing relaxin influenced the generation of intracellular cAMP in the fresh (P&amp;lt;0.01) and frozen-thawed (P&amp;lt;0.05) spermatozoa, and exhibited higher exposure of protein tyrosine phosphorylation in both sperm types than the medium devoid of relaxin. Therefore, the results postulate that relaxin exerts the intracellular signaling cascades involved with capacitation and AR through accelerating the cholesterol efflux, Ca(2+)-influx, intracellular cAMP and protein tyrosine phosphorylation in fresh and frozen-thawed bovine spermatozoa.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70088582" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="13186152" href="https://independent.academia.edu/AbdulGaffarMiah">Abdul Gaffar Miah</a><script data-card-contents-for-user="13186152" type="text/json">{"id":13186152,"first_name":"Abdul Gaffar","last_name":"Miah","domain_name":"independent","page_name":"AbdulGaffarMiah","display_name":"Abdul Gaffar Miah","profile_url":"https://independent.academia.edu/AbdulGaffarMiah?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_70088582 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70088582"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70088582, container: ".js-paper-rank-work_70088582", }); });</script></li><li class="js-percentile-work_70088582 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70088582; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_70088582"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_70088582 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="70088582"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70088582; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70088582]").text(description); $(".js-view-count-work_70088582").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_70088582").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="70088582"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7700" href="https://www.academia.edu/Documents/in/Fluorescence_Microscopy">Fluorescence Microscopy</a>, <script data-card-contents-for-ri="7700" type="text/json">{"id":7700,"name":"Fluorescence Microscopy","url":"https://www.academia.edu/Documents/in/Fluorescence_Microscopy?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9534" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a>, <script data-card-contents-for-ri="9534" type="text/json">{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="18613" href="https://www.academia.edu/Documents/in/Animal_reproduction">Animal reproduction</a>, <script data-card-contents-for-ri="18613" type="text/json">{"id":18613,"name":"Animal reproduction","url":"https://www.academia.edu/Documents/in/Animal_reproduction?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a><script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=70088582]'), work: {"id":70088582,"title":"Intracellular signaling cascades induced by relaxin in the stimulation of capacitation and acrosome reaction in fresh and frozen-thawed bovine spermatozoa","created_at":"2022-01-30T19:05:45.796-08:00","url":"https://www.academia.edu/70088582/Intracellular_signaling_cascades_induced_by_relaxin_in_the_stimulation_of_capacitation_and_acrosome_reaction_in_fresh_and_frozen_thawed_bovine_spermatozoa?f_ri=90514","dom_id":"work_70088582","summary":"Relaxin is one of the 6-kDa peptide hormones, which acts as a pleiotropic endocrine and paracrine factor. Our previous studies revealed that sperm capacitating medium containing relaxin induced capacitation and acrosome reaction (AR) in fresh and frozen-thawed porcine or bovine spermatozoa. However, the intracellular signaling cascades involved with capacitation or AR induced by relaxin was unknown. Therefore, the present study was designed to investigate the intracellular signaling cascades involved with capacitation and AR induced by relaxin in fresh and frozen-thawed bovine spermatozoa. Spermatozoa were incubated in sperm Tyrode\u0026amp;#39;s albumin lactate pyruvate (Sp-TALP) medium supplemented with (40 ng ml(-1)) or without relaxin, and subjected to evaluation of chlortetracycline staining pattern, cholesterol efflux, Ca(2+)-influx, intracellular cyclic adenosine monophosphate (cAMP) and protein tyrosine phosphorylation. Capacitation and AR were increased (P\u0026amp;lt;0.05) in both fresh and frozen-thawed spermatozoa incubated with relaxin. Cholesterol effluxes were greater in the fresh (P\u0026amp;lt;0.01) and frozen-thawed (P\u0026amp;lt;0.05) spermatozoa incubated with relaxin than the spermatozoa incubated without relaxin. Ca(2+)-influxes were also significantly stimulated by relaxin in the fresh (P\u0026amp;lt;0.01) and frozen-thawed (P\u0026amp;lt;0.05) spermatozoa. The Sp-TALP medium containing relaxin influenced the generation of intracellular cAMP in the fresh (P\u0026amp;lt;0.01) and frozen-thawed (P\u0026amp;lt;0.05) spermatozoa, and exhibited higher exposure of protein tyrosine phosphorylation in both sperm types than the medium devoid of relaxin. Therefore, the results postulate that relaxin exerts the intracellular signaling cascades involved with capacitation and AR through accelerating the cholesterol efflux, Ca(2+)-influx, intracellular cAMP and protein tyrosine phosphorylation in fresh and frozen-thawed bovine spermatozoa.","downloadable_attachments":[],"ordered_authors":[{"id":13186152,"first_name":"Abdul Gaffar","last_name":"Miah","domain_name":"independent","page_name":"AbdulGaffarMiah","display_name":"Abdul Gaffar Miah","profile_url":"https://independent.academia.edu/AbdulGaffarMiah?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7700,"name":"Fluorescence Microscopy","url":"https://www.academia.edu/Documents/in/Fluorescence_Microscopy?f_ri=90514","nofollow":false},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=90514","nofollow":false},{"id":18613,"name":"Animal reproduction","url":"https://www.academia.edu/Documents/in/Animal_reproduction?f_ri=90514","nofollow":false},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=90514","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":92680,"name":"cyclic AMP","url":"https://www.academia.edu/Documents/in/cyclic_AMP?f_ri=90514"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle?f_ri=90514"},{"id":846581,"name":"Cell communication","url":"https://www.academia.edu/Documents/in/Cell_communication?f_ri=90514"},{"id":862371,"name":"Spermatozoa","url":"https://www.academia.edu/Documents/in/Spermatozoa?f_ri=90514"},{"id":1048679,"name":"Chlortetracycline","url":"https://www.academia.edu/Documents/in/Chlortetracycline?f_ri=90514"},{"id":1212380,"name":"Intracellular Signaling","url":"https://www.academia.edu/Documents/in/Intracellular_Signaling?f_ri=90514"},{"id":1219924,"name":"Acrosome Reaction","url":"https://www.academia.edu/Documents/in/Acrosome_Reaction?f_ri=90514"},{"id":1953128,"name":"Tyrosine Phosphorylation","url":"https://www.academia.edu/Documents/in/Tyrosine_Phosphorylation?f_ri=90514"},{"id":2156592,"name":"Relaxin","url":"https://www.academia.edu/Documents/in/Relaxin?f_ri=90514"},{"id":2812233,"name":"Sperm capacitation","url":"https://www.academia.edu/Documents/in/Sperm_capacitation?f_ri=90514"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_67328634" data-work_id="67328634" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/67328634/Audit_of_cholesterol_management_among_primary_care_patients_in_rural_southern_Italy">Audit of cholesterol management among primary care patients in rural southern Italy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There has not yet been an audit of achievement rates of therapeutic targets for cholesterol management in the rural Italian primary care setting. The purpose of this study was to measure the percentage of patients with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_67328634" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There has not yet been an audit of achievement rates of therapeutic targets for cholesterol management in the rural Italian primary care setting. The purpose of this study was to measure the percentage of patients with hypercholesterolaemia in a rural primary care setting in southern Italy, classify their risk category and measure the proportions of those patients who achieved optimal cholesterol levels according to the Adult Treatment Panel III guidelines. The audit was completed using records from 1 January 2005 to 31 December 2007. An electronic search key was entered into the electronic clinical records of 10 family doctors in a rural area of southern Italy for subjects with a diagnosis of or being treated for hypercholesterolaemia. A total of 194 hypercholesterolaemic patients were randomly selected from a cohort of patients registered with these family doctors. The low density lipoprotein cholesterol (LDL-C) target level was 100 mg/dL (2.6 mmol/L) in patients with existing car...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/67328634" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="26d375d4257bd292ad48c5784d0d9377" rel="nofollow" data-download="{"attachment_id":78187150,"asset_id":67328634,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78187150/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8409661" href="https://independent.academia.edu/NicolaBuono">Nicola Buono</a><script data-card-contents-for-user="8409661" type="text/json">{"id":8409661,"first_name":"Nicola","last_name":"Buono","domain_name":"independent","page_name":"NicolaBuono","display_name":"Nicola Buono","profile_url":"https://independent.academia.edu/NicolaBuono?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_67328634 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="67328634"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 67328634, container: ".js-paper-rank-work_67328634", }); });</script></li><li class="js-percentile-work_67328634 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67328634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_67328634"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_67328634 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="67328634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67328634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67328634]").text(description); $(".js-view-count-work_67328634").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_67328634").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="67328634"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="588" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2974" href="https://www.academia.edu/Documents/in/Primary_Health_Care">Primary Health Care</a>, <script data-card-contents-for-ri="2974" type="text/json">{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9350" href="https://www.academia.edu/Documents/in/Electronic_Health_Records">Electronic Health Records</a>, <script data-card-contents-for-ri="9350" type="text/json">{"id":9350,"name":"Electronic Health Records","url":"https://www.academia.edu/Documents/in/Electronic_Health_Records?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=67328634]'), work: {"id":67328634,"title":"Audit of cholesterol management among primary care patients in rural southern Italy","created_at":"2022-01-05T23:54:01.101-08:00","url":"https://www.academia.edu/67328634/Audit_of_cholesterol_management_among_primary_care_patients_in_rural_southern_Italy?f_ri=90514","dom_id":"work_67328634","summary":"There has not yet been an audit of achievement rates of therapeutic targets for cholesterol management in the rural Italian primary care setting. The purpose of this study was to measure the percentage of patients with hypercholesterolaemia in a rural primary care setting in southern Italy, classify their risk category and measure the proportions of those patients who achieved optimal cholesterol levels according to the Adult Treatment Panel III guidelines. The audit was completed using records from 1 January 2005 to 31 December 2007. An electronic search key was entered into the electronic clinical records of 10 family doctors in a rural area of southern Italy for subjects with a diagnosis of or being treated for hypercholesterolaemia. A total of 194 hypercholesterolaemic patients were randomly selected from a cohort of patients registered with these family doctors. The low density lipoprotein cholesterol (LDL-C) target level was 100 mg/dL (2.6 mmol/L) in patients with existing car...","downloadable_attachments":[{"id":78187150,"asset_id":67328634,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8409661,"first_name":"Nicola","last_name":"Buono","domain_name":"independent","page_name":"NicolaBuono","display_name":"Nicola Buono","profile_url":"https://independent.academia.edu/NicolaBuono?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=90514","nofollow":false},{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=90514","nofollow":false},{"id":9350,"name":"Electronic Health Records","url":"https://www.academia.edu/Documents/in/Electronic_Health_Records?f_ri=90514","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=90514","nofollow":false},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":91026,"name":"Clinical Audit","url":"https://www.academia.edu/Documents/in/Clinical_Audit?f_ri=90514"},{"id":130343,"name":"Hypercholesterolemia","url":"https://www.academia.edu/Documents/in/Hypercholesterolemia?f_ri=90514"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=90514"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=90514"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=90514"},{"id":559242,"name":"Cardiovascular Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=90514"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=90514"},{"id":1029723,"name":"Rural Health Services","url":"https://www.academia.edu/Documents/in/Rural_Health_Services?f_ri=90514"},{"id":3989031,"name":"Referral and consultation","url":"https://www.academia.edu/Documents/in/Referral_and_consultation?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66611486" data-work_id="66611486" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66611486/Statistical_modelling_of_10_year_fatal_cardiovascular_disease_risk_in_Greece_the_HellenicSCORE_a_calibration_of_the_ESC_SCORE_project_">Statistical modelling of 10-year fatal cardiovascular disease risk in Greece: the HellenicSCORE (a calibration of the ESC SCORE project)</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Interest in the development of functions that estimate the likelihood of an individual suffering a future cardiovascular disease (CVD) event has increased in recent times (e.g. Framingham sheets, SCORE-Systematic COronary Risk Estimation,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_66611486" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Interest in the development of functions that estimate the likelihood of an individual suffering a future cardiovascular disease (CVD) event has increased in recent times (e.g. Framingham sheets, SCORE-Systematic COronary Risk Estimation, PROCAM, etc.). However, the estimates of absolute risk may show substantial variations between different populations, because of geographical, cultural, social, behavioural and genetic differences, as well as various methodological issues related to the predictive models employed. We sought to calibrate the SCORE equations to the Greek population. We used the SCORE system that offers an estimation of total fatal CVD risk in &quot;high&quot; and &quot;low&quot; CVD risk European countries. The project pulls together a pool of datasets from 12 European countries and 2.7 million person-years of observation. A mathematical procedure to adjust the risk estimates for individual countries was applied, based on local mortality and risk factor prevalence da...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66611486" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="607096410673494f006bca09836aa8dd" rel="nofollow" data-download="{"attachment_id":77734209,"asset_id":66611486,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77734209/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1621366" href="https://independent.academia.edu/TFitzgerald">Tony Fitzgerald</a><script data-card-contents-for-user="1621366" type="text/json">{"id":1621366,"first_name":"Tony","last_name":"Fitzgerald","domain_name":"independent","page_name":"TFitzgerald","display_name":"Tony Fitzgerald","profile_url":"https://independent.academia.edu/TFitzgerald?f_ri=90514","photo":"https://0.academia-photos.com/1621366/129476614/118877850/s65_tony.fitzgerald.png"}</script></span></span></li><li class="js-paper-rank-work_66611486 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66611486"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66611486, container: ".js-paper-rank-work_66611486", }); 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$(".js-view-count[data-work-id=66611486]").text(description); $(".js-view-count-work_66611486").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_66611486").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66611486"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2066" href="https://www.academia.edu/Documents/in/Research_Design">Research Design</a>, <script data-card-contents-for-ri="2066" type="text/json">{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="48044" href="https://www.academia.edu/Documents/in/Greece">Greece</a><script data-card-contents-for-ri="48044" type="text/json">{"id":48044,"name":"Greece","url":"https://www.academia.edu/Documents/in/Greece?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66611486]'), work: {"id":66611486,"title":"Statistical modelling of 10-year fatal cardiovascular disease risk in Greece: the HellenicSCORE (a calibration of the ESC SCORE project)","created_at":"2021-12-30T11:38:17.038-08:00","url":"https://www.academia.edu/66611486/Statistical_modelling_of_10_year_fatal_cardiovascular_disease_risk_in_Greece_the_HellenicSCORE_a_calibration_of_the_ESC_SCORE_project_?f_ri=90514","dom_id":"work_66611486","summary":"Interest in the development of functions that estimate the likelihood of an individual suffering a future cardiovascular disease (CVD) event has increased in recent times (e.g. Framingham sheets, SCORE-Systematic COronary Risk Estimation, PROCAM, etc.). However, the estimates of absolute risk may show substantial variations between different populations, because of geographical, cultural, social, behavioural and genetic differences, as well as various methodological issues related to the predictive models employed. We sought to calibrate the SCORE equations to the Greek population. We used the SCORE system that offers an estimation of total fatal CVD risk in \u0026quot;high\u0026quot; and \u0026quot;low\u0026quot; CVD risk European countries. The project pulls together a pool of datasets from 12 European countries and 2.7 million person-years of observation. A mathematical procedure to adjust the risk estimates for individual countries was applied, based on local mortality and risk factor prevalence da...","downloadable_attachments":[{"id":77734209,"asset_id":66611486,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":1621366,"first_name":"Tony","last_name":"Fitzgerald","domain_name":"independent","page_name":"TFitzgerald","display_name":"Tony Fitzgerald","profile_url":"https://independent.academia.edu/TFitzgerald?f_ri=90514","photo":"https://0.academia-photos.com/1621366/129476614/118877850/s65_tony.fitzgerald.png"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=90514","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=90514","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=90514","nofollow":false},{"id":48044,"name":"Greece","url":"https://www.academia.edu/Documents/in/Greece?f_ri=90514","nofollow":false},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=90514"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":96893,"name":"Calibration","url":"https://www.academia.edu/Documents/in/Calibration?f_ri=90514"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=90514"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=90514"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=90514"},{"id":398808,"name":"Coronary heart disease","url":"https://www.academia.edu/Documents/in/Coronary_heart_disease?f_ri=90514"},{"id":559242,"name":"Cardiovascular Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=90514"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=90514"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61515009" data-work_id="61515009" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61515009/Low_Serum_Cholesterol_as_a_Risk_Factor_for_Hemorrhagic_Stroke_in_Men">Low Serum Cholesterol as a Risk Factor for Hemorrhagic Stroke in Men</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61515009" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b7f619c233e17f3859bef21055bd1f64" rel="nofollow" data-download="{"attachment_id":74525173,"asset_id":61515009,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74525173/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24124310" href="https://independent.academia.edu/HiromiMuratani">Hiromi Muratani</a><script data-card-contents-for-user="24124310" type="text/json">{"id":24124310,"first_name":"Hiromi","last_name":"Muratani","domain_name":"independent","page_name":"HiromiMuratani","display_name":"Hiromi Muratani","profile_url":"https://independent.academia.edu/HiromiMuratani?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61515009 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61515009"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61515009, container: ".js-paper-rank-work_61515009", }); });</script></li><li class="js-percentile-work_61515009 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61515009; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_61515009"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_61515009 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="61515009"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61515009; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61515009]").text(description); $(".js-view-count-work_61515009").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61515009").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61515009"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="17158" href="https://www.academia.edu/Documents/in/Japan">Japan</a>, <script data-card-contents-for-ri="17158" type="text/json">{"id":17158,"name":"Japan","url":"https://www.academia.edu/Documents/in/Japan?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="90514" href="https://www.academia.edu/Documents/in/Cholesterol">Cholesterol</a>, <script data-card-contents-for-ri="90514" type="text/json">{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="192721" href="https://www.academia.edu/Documents/in/Risk_factors">Risk factors</a>, <script data-card-contents-for-ri="192721" type="text/json">{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61515009]'), work: {"id":61515009,"title":"Low Serum Cholesterol as a Risk Factor for Hemorrhagic Stroke in Men","created_at":"2021-11-11T05:03:25.246-08:00","url":"https://www.academia.edu/61515009/Low_Serum_Cholesterol_as_a_Risk_Factor_for_Hemorrhagic_Stroke_in_Men?f_ri=90514","dom_id":"work_61515009","summary":null,"downloadable_attachments":[{"id":74525173,"asset_id":61515009,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24124310,"first_name":"Hiromi","last_name":"Muratani","domain_name":"independent","page_name":"HiromiMuratani","display_name":"Hiromi Muratani","profile_url":"https://independent.academia.edu/HiromiMuratani?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":17158,"name":"Japan","url":"https://www.academia.edu/Documents/in/Japan?f_ri=90514","nofollow":false},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514","nofollow":false},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=90514","nofollow":false},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=90514","nofollow":false},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=90514"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=90514"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=90514"},{"id":1159940,"name":"Cerebral Hemorrhage","url":"https://www.academia.edu/Documents/in/Cerebral_Hemorrhage?f_ri=90514"},{"id":1205102,"name":"Cerebrovascular Disorders","url":"https://www.academia.edu/Documents/in/Cerebrovascular_Disorders?f_ri=90514"},{"id":3693190,"name":"mass Screening","url":"https://www.academia.edu/Documents/in/mass_Screening?f_ri=90514"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48118740" data-work_id="48118740" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48118740/Severe_malnutrition_alters_lipid_composition_and_fatty_acid_profile_of_small_intestine_in_newborn_piglets">Severe malnutrition alters lipid composition and fatty acid profile of small intestine in newborn piglets</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The goal of this study was to evaluate the influence of severe protein-energy malnutrition (PEM) on lipid composition and fatty acid profile in the small intestinal mucosa of lactating pigs. Malnutrition was achieved by 80% protein-energy... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_48118740" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The goal of this study was to evaluate the influence of severe protein-energy malnutrition (PEM) on lipid composition and fatty acid profile in the small intestinal mucosa of lactating pigs. Malnutrition was achieved by 80% protein-energy restriction for 30 d (20% of the food intake in the control group) in 7-d-old newborn piglets. Malnourished piglets had significantly lower concentrations of cholesterol, phospholipid and triglycerides in the jejunum and ileum compared with freely fed controls. Fatty acid composition of the intestinal mucosa was severely affected by malnutrition. A sharp decline in the relative percentages of (n-3) and (n-6) long-chain polyunsaturated fatty acids (LC-PUFA) in malnourished piglets paralleled higher (n-9) fatty acid proportions in the total mucosa, microsomes and phospholipids of the jejunum. The structure of the small intestine was severely affected as assessed by light and electron microscopy, and alkaline phosphatase and disaccharidase activities ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48118740" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a961aadf0cbc473a06f6527ac5aab54e" rel="nofollow" data-download="{"attachment_id":66896776,"asset_id":48118740,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66896776/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35683457" href="https://independent.academia.edu/MTorres5">M. 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The structure of the small intestine was severely affected as assessed by light and electron microscopy, and alkaline phosphatase and disaccharidase activities ...","downloadable_attachments":[{"id":66896776,"asset_id":48118740,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35683457,"first_name":"M.","last_name":"Torres","domain_name":"independent","page_name":"MTorres5","display_name":"M. 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itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="4111791" href="https://tbilisi-art.academia.edu/MariKhelashvili">Mari Khelashvili</a><script data-card-contents-for-user="4111791" type="text/json">{"id":4111791,"first_name":"Mari","last_name":"Khelashvili","domain_name":"tbilisi-art","page_name":"MariKhelashvili","display_name":"Mari Khelashvili","profile_url":"https://tbilisi-art.academia.edu/MariKhelashvili?f_ri=90514","photo":"https://0.academia-photos.com/4111791/1589803/1922956/s65_mari.khelashvili.jpg"}</script></span></span></li><li class="js-paper-rank-work_3498626 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="3498626"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 3498626, container: ".js-paper-rank-work_3498626", }); 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u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The mutual influences of wheat selenium (Se) and n-3 polyunsaturated fatty acids (n-3 PUFA) on plasma Se and indicators of increased oxidative stress were investigated in a randomized, double-blind study with 31 women (23.5 +/- 3.4 yr).... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23489930" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The mutual influences of wheat selenium (Se) and n-3 polyunsaturated fatty acids (n-3 PUFA) on plasma Se and indicators of increased oxidative stress were investigated in a randomized, double-blind study with 31 women (23.5 +/- 3.4 yr). Groups 1 and 2 ingested 5.4 g n-3 PUFA daily (as ethyl esters), whereas groups 3 and 4 received placebo capsules. Groups 2 and 3 received 3 slices of high-Se bread daily, providing 115 micrograms Se, in addition to the 77 +/- 26 micrograms Se in the diet. Groups 1 and 4 received placebo slices. Blood samples were drawn at baseline and at 3 and 6 wk. Serum Se concentrations increased in both groups given Se-enriched bread, but significantly less in subjects given n-3 PUFA (group 2). There were no changes in the plasma ratio alpha-tocopherol:mg cholesterol or plasma ascorbic acid levels. In group 1, plasma-conjugated dienes and thiobarbituric acid-reactive substances (TBARS) rose by 130% (p &lt; 0.005) and 126% (p &lt; 0.005), respectively. Two-way ANO...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23489930" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0dc5f321656ec1d997d1f888a91f5afd" rel="nofollow" data-download="{"attachment_id":43926250,"asset_id":23489930,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43926250/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32950721" href="https://independent.academia.edu/AmundMaage">Amund Maage</a><script data-card-contents-for-user="32950721" type="text/json">{"id":32950721,"first_name":"Amund","last_name":"Maage","domain_name":"independent","page_name":"AmundMaage","display_name":"Amund Maage","profile_url":"https://independent.academia.edu/AmundMaage?f_ri=90514","photo":"https://0.academia-photos.com/32950721/10887216/12149894/s65_amund.maage.jpg"}</script></span></span></li><li class="js-paper-rank-work_23489930 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23489930"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23489930, container: ".js-paper-rank-work_23489930", }); 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$(".js-view-count[data-work-id=23489930]").text(description); $(".js-view-count-work_23489930").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23489930").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23489930"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="14292" href="https://www.academia.edu/Documents/in/Oxidative_Stress">Oxidative Stress</a>, <script data-card-contents-for-ri="14292" type="text/json">{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="51645" href="https://www.academia.edu/Documents/in/Norway">Norway</a>, <script data-card-contents-for-ri="51645" type="text/json">{"id":51645,"name":"Norway","url":"https://www.academia.edu/Documents/in/Norway?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="90514" href="https://www.academia.edu/Documents/in/Cholesterol">Cholesterol</a>, <script data-card-contents-for-ri="90514" type="text/json">{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="95519" href="https://www.academia.edu/Documents/in/Selenium">Selenium</a><script data-card-contents-for-ri="95519" type="text/json">{"id":95519,"name":"Selenium","url":"https://www.academia.edu/Documents/in/Selenium?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23489930]'), work: {"id":23489930,"title":"Supplementary selenium influences the response to fatty acid-induced oxidative stress in humans","created_at":"2016-03-20T11:19:57.438-07:00","url":"https://www.academia.edu/23489930/Supplementary_selenium_influences_the_response_to_fatty_acid_induced_oxidative_stress_in_humans?f_ri=90514","dom_id":"work_23489930","summary":"The mutual influences of wheat selenium (Se) and n-3 polyunsaturated fatty acids (n-3 PUFA) on plasma Se and indicators of increased oxidative stress were investigated in a randomized, double-blind study with 31 women (23.5 +/- 3.4 yr). Groups 1 and 2 ingested 5.4 g n-3 PUFA daily (as ethyl esters), whereas groups 3 and 4 received placebo capsules. Groups 2 and 3 received 3 slices of high-Se bread daily, providing 115 micrograms Se, in addition to the 77 +/- 26 micrograms Se in the diet. Groups 1 and 4 received placebo slices. Blood samples were drawn at baseline and at 3 and 6 wk. Serum Se concentrations increased in both groups given Se-enriched bread, but significantly less in subjects given n-3 PUFA (group 2). There were no changes in the plasma ratio alpha-tocopherol:mg cholesterol or plasma ascorbic acid levels. In group 1, plasma-conjugated dienes and thiobarbituric acid-reactive substances (TBARS) rose by 130% (p \u0026lt; 0.005) and 126% (p \u0026lt; 0.005), respectively. Two-way ANO...","downloadable_attachments":[{"id":43926250,"asset_id":23489930,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32950721,"first_name":"Amund","last_name":"Maage","domain_name":"independent","page_name":"AmundMaage","display_name":"Amund Maage","profile_url":"https://independent.academia.edu/AmundMaage?f_ri=90514","photo":"https://0.academia-photos.com/32950721/10887216/12149894/s65_amund.maage.jpg"}],"research_interests":[{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=90514","nofollow":false},{"id":51645,"name":"Norway","url":"https://www.academia.edu/Documents/in/Norway?f_ri=90514","nofollow":false},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514","nofollow":false},{"id":95519,"name":"Selenium","url":"https://www.academia.edu/Documents/in/Selenium?f_ri=90514","nofollow":false},{"id":103298,"name":"Blood sampling","url":"https://www.academia.edu/Documents/in/Blood_sampling?f_ri=90514"},{"id":156734,"name":"Vitamin E","url":"https://www.academia.edu/Documents/in/Vitamin_E?f_ri=90514"},{"id":233372,"name":"Lipid peroxidation","url":"https://www.academia.edu/Documents/in/Lipid_peroxidation?f_ri=90514"},{"id":352757,"name":"Ascorbic Acid","url":"https://www.academia.edu/Documents/in/Ascorbic_Acid?f_ri=90514"},{"id":486713,"name":"Fatty Acid","url":"https://www.academia.edu/Documents/in/Fatty_Acid?f_ri=90514"},{"id":487159,"name":"Group","url":"https://www.academia.edu/Documents/in/Group?f_ri=90514"},{"id":592549,"name":"Interaction effect","url":"https://www.academia.edu/Documents/in/Interaction_effect?f_ri=90514"},{"id":709300,"name":"Trace element","url":"https://www.academia.edu/Documents/in/Trace_element?f_ri=90514"},{"id":881060,"name":"Seed Treatment","url":"https://www.academia.edu/Documents/in/Seed_Treatment?f_ri=90514"},{"id":1244809,"name":"Thiobarbituric Acid Reactive Substance","url":"https://www.academia.edu/Documents/in/Thiobarbituric_Acid_Reactive_Substance?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14816223" data-work_id="14816223" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14816223/Serum_Fructosamine_and_Lipid_Profile_in_Children_with_Malignant_Diseases">Serum Fructosamine and Lipid Profile in Children with Malignant Diseases</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14816223" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="73bd6edde7dac2473c3f396fbae5b50c" rel="nofollow" data-download="{"attachment_id":43877528,"asset_id":14816223,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43877528/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33775770" href="https://independent.academia.edu/MehmetTas1">Mehmet Tas</a><script data-card-contents-for-user="33775770" type="text/json">{"id":33775770,"first_name":"Mehmet","last_name":"Tas","domain_name":"independent","page_name":"MehmetTas1","display_name":"Mehmet Tas","profile_url":"https://independent.academia.edu/MehmetTas1?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14816223 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14816223"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14816223, container: ".js-paper-rank-work_14816223", }); });</script></li><li class="js-percentile-work_14816223 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14816223; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14816223"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14816223 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14816223"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14816223; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14816223]").text(description); $(".js-view-count-work_14816223").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14816223").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14816223"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="631" href="https://www.academia.edu/Documents/in/Pediatrics">Pediatrics</a>, <script data-card-contents-for-ri="631" type="text/json">{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="90514" href="https://www.academia.edu/Documents/in/Cholesterol">Cholesterol</a><script data-card-contents-for-ri="90514" type="text/json">{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14816223]'), work: {"id":14816223,"title":"Serum Fructosamine and Lipid Profile in Children with Malignant Diseases","created_at":"2015-08-10T03:31:47.431-07:00","url":"https://www.academia.edu/14816223/Serum_Fructosamine_and_Lipid_Profile_in_Children_with_Malignant_Diseases?f_ri=90514","dom_id":"work_14816223","summary":null,"downloadable_attachments":[{"id":43877528,"asset_id":14816223,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33775770,"first_name":"Mehmet","last_name":"Tas","domain_name":"independent","page_name":"MehmetTas1","display_name":"Mehmet Tas","profile_url":"https://independent.academia.edu/MehmetTas1?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=90514","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=90514","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=90514","nofollow":false},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514","nofollow":false},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=90514"},{"id":227299,"name":"Triglycerides","url":"https://www.academia.edu/Documents/in/Triglycerides?f_ri=90514"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=90514"},{"id":801998,"name":"Lipid Profile","url":"https://www.academia.edu/Documents/in/Lipid_Profile?f_ri=90514"},{"id":1612404,"name":"Hexosamines","url":"https://www.academia.edu/Documents/in/Hexosamines?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16696574" data-work_id="16696574" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16696574/The_Utrecht_Diabetes_Project_telemedicine_support_improves_GP_care_in_Type_2_diabetes">The Utrecht Diabetes Project: telemedicine support improves GP care in Type 2 diabetes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The Utrecht Diabetes Project (UDP) is a shared-care project providing remote diabetologist support for 85 GPs. In the UDP all examinations, performed by the GP, follow standardized procedures, results being sent to the diabetologist.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16696574" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The Utrecht Diabetes Project (UDP) is a shared-care project providing remote diabetologist support for 85 GPs. In the UDP all examinations, performed by the GP, follow standardized procedures, results being sent to the diabetologist. Laboratory results are sent automatically to both GP and diabetologist. To study the composition of the UDP population; completeness of data recording; changes in biochemical variables of UDP patients; and GPs&amp;#39; motives for enrolling them. Data were extracted from the records of 19 GPs and a questionnaire was sent to all UDP GPs. Of 770 patients with Type 2 diabetes, 44% were treated with UDP support, 29% by their GPs alone, and 27% at out-patient clinics. The 336 UDP patients were representative of all UDP patients. Patients older than 75 years were the greater part of those treated by GPs alone; out-patient clinics had more patients with diabetes &amp;gt; 10 years or with complications. UDP patients&amp;#39; records were the most complete. Diabetes regulation, lipid levels and diastolic blood pressure in the UDP patients improved significantly after inclusion in the UDP. GPs tend to seek UDP aid especially for patients who are young, or of recent onset, at risk of macrovascular complications, or needing insulin. Standardized data transfer between GP, diabetologist and laboratory might establish an effective infrastructure for shared diabetes care. Diabet. Med. 18, 459-463 (2001)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16696574" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="442e40773403687165bd8fb48a08d21f" rel="nofollow" data-download="{"attachment_id":42414535,"asset_id":16696574,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42414535/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36077823" href="https://independent.academia.edu/GEHMRutten">G. E. H. M. Rutten</a><script data-card-contents-for-user="36077823" type="text/json">{"id":36077823,"first_name":"G. E. H. M.","last_name":"Rutten","domain_name":"independent","page_name":"GEHMRutten","display_name":"G. E. H. M. 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In the UDP all examinations, performed by the GP, follow standardized procedures, results being sent to the diabetologist. Laboratory results are sent automatically to both GP and diabetologist. To study the composition of the UDP population; completeness of data recording; changes in biochemical variables of UDP patients; and GPs\u0026amp;#39; motives for enrolling them. Data were extracted from the records of 19 GPs and a questionnaire was sent to all UDP GPs. Of 770 patients with Type 2 diabetes, 44% were treated with UDP support, 29% by their GPs alone, and 27% at out-patient clinics. The 336 UDP patients were representative of all UDP patients. Patients older than 75 years were the greater part of those treated by GPs alone; out-patient clinics had more patients with diabetes \u0026amp;gt; 10 years or with complications. UDP patients\u0026amp;#39; records were the most complete. Diabetes regulation, lipid levels and diastolic blood pressure in the UDP patients improved significantly after inclusion in the UDP. GPs tend to seek UDP aid especially for patients who are young, or of recent onset, at risk of macrovascular complications, or needing insulin. Standardized data transfer between GP, diabetologist and laboratory might establish an effective infrastructure for shared diabetes care. Diabet. Med. 18, 459-463 (2001)","downloadable_attachments":[{"id":42414535,"asset_id":16696574,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36077823,"first_name":"G. E. H. M.","last_name":"Rutten","domain_name":"independent","page_name":"GEHMRutten","display_name":"G. E. H. M. Rutten","profile_url":"https://independent.academia.edu/GEHMRutten?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2725,"name":"Documentation","url":"https://www.academia.edu/Documents/in/Documentation?f_ri=90514","nofollow":false},{"id":23324,"name":"Telemedicine","url":"https://www.academia.edu/Documents/in/Telemedicine?f_ri=90514","nofollow":false},{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=90514","nofollow":false},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=90514","nofollow":false},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":96573,"name":"Diabetic Retinopathy","url":"https://www.academia.edu/Documents/in/Diabetic_Retinopathy?f_ri=90514"},{"id":157892,"name":"Netherlands","url":"https://www.academia.edu/Documents/in/Netherlands?f_ri=90514"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=90514"},{"id":227299,"name":"Triglycerides","url":"https://www.academia.edu/Documents/in/Triglycerides?f_ri=90514"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=90514"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=90514"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=90514"},{"id":874382,"name":"Medical Records","url":"https://www.academia.edu/Documents/in/Medical_Records?f_ri=90514"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus?f_ri=90514"}]}, }) } 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class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9815" href="https://www.academia.edu/Documents/in/Developing_Countries">Developing Countries</a>, <script data-card-contents-for-ri="9815" type="text/json">{"id":9815,"name":"Developing Countries","url":"https://www.academia.edu/Documents/in/Developing_Countries?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="14406" href="https://www.academia.edu/Documents/in/Health">Health</a><script data-card-contents-for-ri="14406" type="text/json">{"id":14406,"name":"Health","url":"https://www.academia.edu/Documents/in/Health?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=47776883]'), work: {"id":47776883,"title":"A Cholesterol-Rich Diet Accelerates Bacteriologic Sterilization in Pulmonary Tuberculosis\u003cxref rid=\"AFF1\"\u003e\u003csup\u003e*\u003c/sup\u003e\u003c/xref\u003e","created_at":"2021-04-29T07:22:19.852-07:00","url":"https://www.academia.edu/47776883/A_Cholesterol_Rich_Diet_Accelerates_Bacteriologic_Sterilization_in_Pulmonary_Tuberculosis_xref_rid_AFF1_sup_sup_xref_?f_ri=90514","dom_id":"work_47776883","summary":null,"downloadable_attachments":[{"id":66718963,"asset_id":47776883,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":150292378,"first_name":"Francisco","last_name":"Quiñonez","domain_name":"independent","page_name":"FranciscoQuiñonez4","display_name":"Francisco Quiñonez","profile_url":"https://independent.academia.edu/FranciscoQui%C3%B1onez4?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1907,"name":"Nutrition","url":"https://www.academia.edu/Documents/in/Nutrition?f_ri=90514","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=90514","nofollow":false},{"id":9815,"name":"Developing Countries","url":"https://www.academia.edu/Documents/in/Developing_Countries?f_ri=90514","nofollow":false},{"id":14406,"name":"Health","url":"https://www.academia.edu/Documents/in/Health?f_ri=90514","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=90514"},{"id":43881,"name":"Mexico","url":"https://www.academia.edu/Documents/in/Mexico?f_ri=90514"},{"id":68318,"name":"Mycobacterium tuberculosis","url":"https://www.academia.edu/Documents/in/Mycobacterium_tuberculosis?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria?f_ri=90514"},{"id":159742,"name":"Microbial","url":"https://www.academia.edu/Documents/in/Microbial?f_ri=90514"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=90514"},{"id":395187,"name":"Clients","url":"https://www.academia.edu/Documents/in/Clients?f_ri=90514"},{"id":532928,"name":"Chest","url":"https://www.academia.edu/Documents/in/Chest?f_ri=90514"},{"id":617771,"name":"MEXICO","url":"https://www.academia.edu/Documents/in/MEXICO-2015?f_ri=90514"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73945530" data-work_id="73945530" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73945530/Mycoplasma_penetrans_sp_nov_from_the_Urogenital_Tract_of_Patients_with_AIDS">Mycoplasma penetrans sp. nov., from the Urogenital Tract of Patients with AIDS</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73945530" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fb92cd4c6fd0ee774c118f5e73889a6c" rel="nofollow" data-download="{"attachment_id":82278788,"asset_id":73945530,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82278788/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" 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Charcoal","url":"https://www.academia.edu/Documents/in/Activated_Charcoal?f_ri=90514"},{"id":745950,"name":"Phytosterols","url":"https://www.academia.edu/Documents/in/Phytosterols?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_51500355" data-work_id="51500355" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/51500355/Effect_of_lifestyle_changes_and_atorvastatin_administration_on_dyslipidemia_in_hemodialysis_patients_a_prospective_study">Effect of lifestyle changes and atorvastatin administration on dyslipidemia in hemodialysis patients: a prospective study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Atherogenic dyslipidemia accelerates the development of cardiovascular complications and contributes to mortality of hemodialysis (HD) patients. The aim of the study was to evaluate the effects of lifestyle changes followed by treatment... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_51500355" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Atherogenic dyslipidemia accelerates the development of cardiovascular complications and contributes to mortality of hemodialysis (HD) patients. The aim of the study was to evaluate the effects of lifestyle changes followed by treatment with atorvastatin in dyslipidemic HD patients. Dyslipidemic HD patients (n = 49) were enrolled into the prospective study. Forty-two patients completed a 21-week lifestyle intervention. In 34 patients, who continued to be dyslipidemic, atorvastatin was used for 14 weeks. After 4 weeks, the initial dose of atorvastatin of 10 mg/d was increased to 20 mg/d in dyslipidemic patients. The most pronounced effects of lifestyle changes were shown at 14 weeks and included significant differences in high-density lipoprotein cholesterol, low-density lipoprotein (LDL) cholesterol, salusin α, malondialdehyde-oxidized LDL, fructosamine, and monocyte CD36 expression. Immunoglobulin G anti-oxLDL showed the highest values at 21 weeks. Seven patients (16.7%) were nondy...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/51500355" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="14234b95e85f10497aebc484bcb30909" rel="nofollow" data-download="{"attachment_id":69199329,"asset_id":51500355,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/69199329/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="135771513" href="https://independent.academia.edu/Ma%C5%82gorzataJank%C3%B3w">Małgorzata Janków</a><script data-card-contents-for-user="135771513" type="text/json">{"id":135771513,"first_name":"Małgorzata","last_name":"Janków","domain_name":"independent","page_name":"MałgorzataJanków","display_name":"Małgorzata Janków","profile_url":"https://independent.academia.edu/Ma%C5%82gorzataJank%C3%B3w?f_ri=90514","photo":"https://0.academia-photos.com/135771513/36361341/31170658/s65_ma_gorzata.jank_w.jpg"}</script></span></span></li><li class="js-paper-rank-work_51500355 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="51500355"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 51500355, container: ".js-paper-rank-work_51500355", }); 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The aim of the study was to evaluate the effects of lifestyle changes followed by treatment with atorvastatin in dyslipidemic HD patients. Dyslipidemic HD patients (n = 49) were enrolled into the prospective study. Forty-two patients completed a 21-week lifestyle intervention. In 34 patients, who continued to be dyslipidemic, atorvastatin was used for 14 weeks. After 4 weeks, the initial dose of atorvastatin of 10 mg/d was increased to 20 mg/d in dyslipidemic patients. The most pronounced effects of lifestyle changes were shown at 14 weeks and included significant differences in high-density lipoprotein cholesterol, low-density lipoprotein (LDL) cholesterol, salusin α, malondialdehyde-oxidized LDL, fructosamine, and monocyte CD36 expression. Immunoglobulin G anti-oxLDL showed the highest values at 21 weeks. Seven patients (16.7%) were nondy...","downloadable_attachments":[{"id":69199329,"asset_id":51500355,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":135771513,"first_name":"Małgorzata","last_name":"Janków","domain_name":"independent","page_name":"MałgorzataJanków","display_name":"Małgorzata Janków","profile_url":"https://independent.academia.edu/Ma%C5%82gorzataJank%C3%B3w?f_ri=90514","photo":"https://0.academia-photos.com/135771513/36361341/31170658/s65_ma_gorzata.jank_w.jpg"}],"research_interests":[{"id":7471,"name":"Life Style","url":"https://www.academia.edu/Documents/in/Life_Style?f_ri=90514","nofollow":false},{"id":62112,"name":"Prospective 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Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure?f_ri=90514"},{"id":2523123,"name":"Low density lipoprotein cholesterol","url":"https://www.academia.edu/Documents/in/Low_density_lipoprotein_cholesterol?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5423947" data-work_id="5423947" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5423947/Efficacy_of_simvastatin_in_children_with_hyperlipidemia_secondary_to_kidney_disorders">Efficacy of simvastatin in children with hyperlipidemia secondary to kidney disorders</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Children with hyperlipidemia secondary to renal disease develop premature atherosclerosis and glomerulosclerosis. The aims of this pilot study were to find the dosage and short-term efficacy of simvastatin and potential adverse events in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5423947" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Children with hyperlipidemia secondary to renal disease develop premature atherosclerosis and glomerulosclerosis. The aims of this pilot study were to find the dosage and short-term efficacy of simvastatin and potential adverse events in children with chronic kidney diseases. This was a random, double-blind, placebo-controlled, cross-over clinical trial performed on children with hyperlipidemia secondary to kidney disorders. After being placed on a diet for 3 months, patients were randomly placed in one of two balanced group blocks and treated with diet plus placebo or simvastatin at doses of 5 mg for children weighing 30 kg or less and 10 mg for children weighing over 30 kg, for 1 month, and then doubled for two more months. After this treatment, patients were placed on a diet for a 3-month washout period. During the last trial phase, patients previously treated with simvastatin were administered a placebo, and vice versa. A total of 25 patients with ages ranging from 4 years to 17 years were included in the study. A significant decrease in the levels of serum cholesterol (26.4%), low-density lipoprotein (LDL) (35.4%) and triglycerides (23.1%) was noted during the study, primarily during the simvastatin treatments, in which case cholesterol, LDL and triglycerides decreased by 23.3%, 33.7% and 21%, respectively. High-density lipoprotein (HDL) levels increased moderately (10.7%) during the study but without differences during simvastatin treatment. No differences were found across groups with respect to adverse events. In the short-term the combination of diet and simvastatin was effective in lowering hyperlipidemia in children with renal disorders.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5423947" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="38aa37025fc2497ac0593b0f838aa93c" rel="nofollow" data-download="{"attachment_id":49298504,"asset_id":5423947,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49298504/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7582432" href="https://independent.academia.edu/Mar%C3%ADaMartinezMaya">María Martinez Maya</a><script data-card-contents-for-user="7582432" type="text/json">{"id":7582432,"first_name":"María","last_name":"Martinez Maya","domain_name":"independent","page_name":"MaríaMartinezMaya","display_name":"María Martinez Maya","profile_url":"https://independent.academia.edu/Mar%C3%ADaMartinezMaya?f_ri=90514","photo":"https://0.academia-photos.com/7582432/3042479/3576388/s65_mar_a.martinez_maya.jpg"}</script></span></span></li><li class="js-paper-rank-work_5423947 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5423947"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5423947, container: ".js-paper-rank-work_5423947", }); 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A significant decrease in the levels of serum cholesterol (26.4%), low-density lipoprotein (LDL) (35.4%) and triglycerides (23.1%) was noted during the study, primarily during the simvastatin treatments, in which case cholesterol, LDL and triglycerides decreased by 23.3%, 33.7% and 21%, respectively. High-density lipoprotein (HDL) levels increased moderately (10.7%) during the study but without differences during simvastatin treatment. No differences were found across groups with respect to adverse events. 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data-work_id="7157827" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7157827/Overexpression_of_11%CE%B2_Hydroxysteroid_Dehydrogenase_Type_1_in_Hepatic_and_Visceral_Adipose_Tissue_is_Associated_with_Metabolic_Disorders_in_Morbidly_Obese_Patients">Overexpression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background The enzyme 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes intracellular glucocorticoid reactivation by conversion of cortisone to cortisol in different tissues and have been implicated in several metabolic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7157827" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background The enzyme 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes intracellular glucocorticoid reactivation by conversion of cortisone to cortisol in different tissues and have been implicated in several metabolic disorders associated with obesity. The aim of this study was to evaluate the 11β-HSD1 expression in liver, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) in morbidly obese patients undergoing bariatric surgery and its correlations with clinical, anthropometric, and biochemical variables. Methods A prospective study was conducted over a 27-month period. Hepatic, VAT, and SAT samples were obtained at the time of surgery. 11β-HSD1 and 18S gene expression was measured using real-time quantitative reverse transcriptase-polymerase chain reaction. Results Forty nine patients met the inclusion criteria [mean age: 42.2 ± 10 years, body mass index (BMI): 42 ± 6 kg/m2, 71% women and 63% with metabolic syndrome (MS)]. 11β-HSD1 mRNA levels were higher in liver than fat tissue (p < 0.001), being higher in SAT than in VAT (p < 0.001) without gender-specific differences. Hepatic expression of 11β-HSD1 correlated positively with SAT and VAT, alanine aminotransferase (ALT), and serum glucose and was inversely associated with BMI. 11β-HSD1 mRNA in VAT correlated positively with insulinemia, ALT, and LDL cholesterol. There were no associations between 11β-HSD1 mRNA in SAT and the variables analyzed. Conclusions 11β-HSD1 expression is higher in liver in comparison to adipose tissue in obese patients. The observed correlations between hepatic and VAT 11β-HSD1 expression with dyslipidemia and insulin resistance suggest that this enzyme might have a pathogenic role in obesity and related metabolic disorders.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7157827" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="675bbf62f112e7ebe4b8cfe7479139f7" rel="nofollow" data-download="{"attachment_id":48577516,"asset_id":7157827,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48577516/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12366896" href="https://independent.academia.edu/MauricioMorales9">Mauricio Morales</a><script data-card-contents-for-user="12366896" type="text/json">{"id":12366896,"first_name":"Mauricio","last_name":"Morales","domain_name":"independent","page_name":"MauricioMorales9","display_name":"Mauricio Morales","profile_url":"https://independent.academia.edu/MauricioMorales9?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_7157827 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7157827"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7157827, container: ".js-paper-rank-work_7157827", }); 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$(".js-view-count[data-work-id=7157827]").text(description); $(".js-view-count-work_7157827").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_7157827").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="7157827"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">38</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="648" href="https://www.academia.edu/Documents/in/Bariatric_Surgery">Bariatric Surgery</a>, <script data-card-contents-for-ri="648" type="text/json">{"id":648,"name":"Bariatric Surgery","url":"https://www.academia.edu/Documents/in/Bariatric_Surgery?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3851" href="https://www.academia.edu/Documents/in/Obesity">Obesity</a>, <script data-card-contents-for-ri="3851" type="text/json">{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="27784" href="https://www.academia.edu/Documents/in/Gene_expression">Gene expression</a>, <script data-card-contents-for-ri="27784" type="text/json">{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37818" href="https://www.academia.edu/Documents/in/Metabolic_syndrome">Metabolic syndrome</a><script data-card-contents-for-ri="37818" type="text/json">{"id":37818,"name":"Metabolic syndrome","url":"https://www.academia.edu/Documents/in/Metabolic_syndrome?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7157827]'), work: {"id":7157827,"title":"Overexpression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients","created_at":"2014-05-25T20:35:01.474-07:00","url":"https://www.academia.edu/7157827/Overexpression_of_11%CE%B2_Hydroxysteroid_Dehydrogenase_Type_1_in_Hepatic_and_Visceral_Adipose_Tissue_is_Associated_with_Metabolic_Disorders_in_Morbidly_Obese_Patients?f_ri=90514","dom_id":"work_7157827","summary":"Background The enzyme 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes intracellular glucocorticoid reactivation by conversion of cortisone to cortisol in different tissues and have been implicated in several metabolic disorders associated with obesity. The aim of this study was to evaluate the 11β-HSD1 expression in liver, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) in morbidly obese patients undergoing bariatric surgery and its correlations with clinical, anthropometric, and biochemical variables. Methods A prospective study was conducted over a 27-month period. Hepatic, VAT, and SAT samples were obtained at the time of surgery. 11β-HSD1 and 18S gene expression was measured using real-time quantitative reverse transcriptase-polymerase chain reaction. Results Forty nine patients met the inclusion criteria [mean age: 42.2 ± 10 years, body mass index (BMI): 42 ± 6 kg/m2, 71% women and 63% with metabolic syndrome (MS)]. 11β-HSD1 mRNA levels were higher in liver than fat tissue (p \u003c 0.001), being higher in SAT than in VAT (p \u003c 0.001) without gender-specific differences. Hepatic expression of 11β-HSD1 correlated positively with SAT and VAT, alanine aminotransferase (ALT), and serum glucose and was inversely associated with BMI. 11β-HSD1 mRNA in VAT correlated positively with insulinemia, ALT, and LDL cholesterol. There were no associations between 11β-HSD1 mRNA in SAT and the variables analyzed. Conclusions 11β-HSD1 expression is higher in liver in comparison to adipose tissue in obese patients. The observed correlations between hepatic and VAT 11β-HSD1 expression with dyslipidemia and insulin resistance suggest that this enzyme might have a pathogenic role in obesity and related metabolic disorders.","downloadable_attachments":[{"id":48577516,"asset_id":7157827,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":12366896,"first_name":"Mauricio","last_name":"Morales","domain_name":"independent","page_name":"MauricioMorales9","display_name":"Mauricio Morales","profile_url":"https://independent.academia.edu/MauricioMorales9?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":648,"name":"Bariatric Surgery","url":"https://www.academia.edu/Documents/in/Bariatric_Surgery?f_ri=90514","nofollow":false},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity?f_ri=90514","nofollow":false},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=90514","nofollow":false},{"id":37818,"name":"Metabolic syndrome","url":"https://www.academia.edu/Documents/in/Metabolic_syndrome?f_ri=90514","nofollow":false},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance?f_ri=90514"},{"id":51784,"name":"real time PCR","url":"https://www.academia.edu/Documents/in/real_time_PCR?f_ri=90514"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue?f_ri=90514"},{"id":58431,"name":"Cortisol","url":"https://www.academia.edu/Documents/in/Cortisol?f_ri=90514"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver?f_ri=90514"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":103297,"name":"Corticosterone","url":"https://www.academia.edu/Documents/in/Corticosterone?f_ri=90514"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=90514"},{"id":151036,"name":"non alcoholic fatty liver disease (NAFLD)","url":"https://www.academia.edu/Documents/in/non_alcoholic_fatty_liver_disease_NAFLD_?f_ri=90514"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=90514"},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve?f_ri=90514"},{"id":218811,"name":"Obesity Surgery","url":"https://www.academia.edu/Documents/in/Obesity_Surgery?f_ri=90514"},{"id":227299,"name":"Triglycerides","url":"https://www.academia.edu/Documents/in/Triglycerides?f_ri=90514"},{"id":227308,"name":"LDL-cholesterol","url":"https://www.academia.edu/Documents/in/LDL-cholesterol?f_ri=90514"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme?f_ri=90514"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=90514"},{"id":295465,"name":"Fatty Liver","url":"https://www.academia.edu/Documents/in/Fatty_Liver?f_ri=90514"},{"id":353163,"name":"Fat Mass","url":"https://www.academia.edu/Documents/in/Fat_Mass?f_ri=90514"},{"id":353233,"name":"Body mass index (BMI)","url":"https://www.academia.edu/Documents/in/Body_mass_index_BMI_?f_ri=90514"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=90514"},{"id":425213,"name":"Alanine Aminotransferase","url":"https://www.academia.edu/Documents/in/Alanine_Aminotransferase?f_ri=90514"},{"id":437772,"name":"Odds ratio","url":"https://www.academia.edu/Documents/in/Odds_ratio?f_ri=90514"},{"id":462111,"name":"Western blot","url":"https://www.academia.edu/Documents/in/Western_blot?f_ri=90514"},{"id":501806,"name":"Protein Expression","url":"https://www.academia.edu/Documents/in/Protein_Expression?f_ri=90514"},{"id":900002,"name":"Metabolic Disorder","url":"https://www.academia.edu/Documents/in/Metabolic_Disorder?f_ri=90514"},{"id":1130442,"name":"Abdominal Obesity","url":"https://www.academia.edu/Documents/in/Abdominal_Obesity?f_ri=90514"},{"id":1225734,"name":"Fasting Insulin","url":"https://www.academia.edu/Documents/in/Fasting_Insulin?f_ri=90514"},{"id":1272906,"name":"Enzyme Linked Immunosorbent 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Results from 22.5 years' follow-up","created_at":"2016-08-10T02:15:32.722-07:00","url":"https://www.academia.edu/27671326/Prediction_of_Type_2_diabetes_in_healthy_middle_aged_men_with_special_emphasis_on_glucose_homeostasis_Results_from_22_5_years_follow_up?f_ri=90514","dom_id":"work_27671326","summary":null,"downloadable_attachments":[{"id":47937924,"asset_id":27671326,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51899895,"first_name":"Erik","last_name":"Thaulow","domain_name":"uio","page_name":"ErikThaulow","display_name":"Erik Thaulow","profile_url":"https://uio.academia.edu/ErikThaulow?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=90514","nofollow":false},{"id":41482,"name":"Multivariate 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López</a><script data-card-contents-for-user="11243951" type="text/json">{"id":11243951,"first_name":"Mercedes G.","last_name":"López","domain_name":"cinvestav","page_name":"MercedesGLópez","display_name":"Mercedes G. 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We investigated the effects that pinealectomy and the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20642506" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">It is generally agreed that physiological levels of melatonin, a hormone secreted by the pineal gland, are important in protecting against oxidative stress-induced tissue damage. We investigated the effects that pinealectomy and the administration of exogenous melatonin have on the brains, testes, duodena and stomachs of rats. Pinealectomized (Px) and sham-operated (non-Px) rats were used. We evaluated structural changes, and catalase (CAT), reduced glutathione (GSH), super oxide dismutase (SOD) and malondialdehyde (MDA) levels. The rats were divided into the following five groups (eight rats in each group): sham (non-Px), Px+ vehicle, Px+ melatonin (10 mg/kg given daily intraperitoneally for a week), melatonin and ethyl alcohol. The antioxidant levels in the tissue of Px rats were significantly lower than in those of the sham group. Administering melatonin significantly increased antioxidant levels (p &lt; 0.05). The Px rats also showed a significant increase in MDA levels when com...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20642506" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0448608620c2829a3cfabc9908808261" rel="nofollow" data-download="{"attachment_id":41937538,"asset_id":20642506,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41937538/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41962496" href="https://independent.academia.edu/SedaTasdemir">Seda Tasdemir</a><script data-card-contents-for-user="41962496" type="text/json">{"id":41962496,"first_name":"Seda","last_name":"Tasdemir","domain_name":"independent","page_name":"SedaTasdemir","display_name":"Seda Tasdemir","profile_url":"https://independent.academia.edu/SedaTasdemir?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20642506 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20642506"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20642506, container: ".js-paper-rank-work_20642506", }); 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$(".js-view-count[data-work-id=20642506]").text(description); $(".js-view-count-work_20642506").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20642506").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20642506"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">45</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12071" href="https://www.academia.edu/Documents/in/Immunohistochemistry">Immunohistochemistry</a>, <script data-card-contents-for-ri="12071" type="text/json">{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="14292" href="https://www.academia.edu/Documents/in/Oxidative_Stress">Oxidative Stress</a><script data-card-contents-for-ri="14292" type="text/json">{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20642506]'), work: {"id":20642506,"title":"Effects of pinealectomy and exogenous melatonin on the brains, testes, duodena and stomachs of rats","created_at":"2016-01-23T09:10:49.111-08:00","url":"https://www.academia.edu/20642506/Effects_of_pinealectomy_and_exogenous_melatonin_on_the_brains_testes_duodena_and_stomachs_of_rats?f_ri=90514","dom_id":"work_20642506","summary":"It is generally agreed that physiological levels of melatonin, a hormone secreted by the pineal gland, are important in protecting against oxidative stress-induced tissue damage. We investigated the effects that pinealectomy and the administration of exogenous melatonin have on the brains, testes, duodena and stomachs of rats. Pinealectomized (Px) and sham-operated (non-Px) rats were used. We evaluated structural changes, and catalase (CAT), reduced glutathione (GSH), super oxide dismutase (SOD) and malondialdehyde (MDA) levels. The rats were divided into the following five groups (eight rats in each group): sham (non-Px), Px+ vehicle, Px+ melatonin (10 mg/kg given daily intraperitoneally for a week), melatonin and ethyl alcohol. The antioxidant levels in the tissue of Px rats were significantly lower than in those of the sham group. Administering melatonin significantly increased antioxidant levels (p \u0026lt; 0.05). The Px rats also showed a significant increase in MDA levels when com...","downloadable_attachments":[{"id":41937538,"asset_id":20642506,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41962496,"first_name":"Seda","last_name":"Tasdemir","domain_name":"independent","page_name":"SedaTasdemir","display_name":"Seda Tasdemir","profile_url":"https://independent.academia.edu/SedaTasdemir?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=90514","nofollow":false},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=90514","nofollow":false},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=90514","nofollow":false},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=90514","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=90514"},{"id":41783,"name":"Ghrelin","url":"https://www.academia.edu/Documents/in/Ghrelin?f_ri=90514"},{"id":51570,"name":"Melatonin","url":"https://www.academia.edu/Documents/in/Melatonin?f_ri=90514"},{"id":51711,"name":"Antioxidants","url":"https://www.academia.edu/Documents/in/Antioxidants?f_ri=90514"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione?f_ri=90514"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=90514"},{"id":135357,"name":"Leptin","url":"https://www.academia.edu/Documents/in/Leptin?f_ri=90514"},{"id":139007,"name":"Catalase","url":"https://www.academia.edu/Documents/in/Catalase?f_ri=90514"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis?f_ri=90514"},{"id":177247,"name":"Arcuate Nucleus","url":"https://www.academia.edu/Documents/in/Arcuate_Nucleus?f_ri=90514"},{"id":178851,"name":"Cytoprotection","url":"https://www.academia.edu/Documents/in/Cytoprotection?f_ri=90514"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=90514"},{"id":203521,"name":"tESTIS","url":"https://www.academia.edu/Documents/in/tESTIS?f_ri=90514"},{"id":213343,"name":"Superoxide Dismutase","url":"https://www.academia.edu/Documents/in/Superoxide_Dismutase?f_ri=90514"},{"id":218820,"name":"Eating","url":"https://www.academia.edu/Documents/in/Eating?f_ri=90514"},{"id":247477,"name":"Caspase","url":"https://www.academia.edu/Documents/in/Caspase?f_ri=90514"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=90514"},{"id":328063,"name":"Heart valves","url":"https://www.academia.edu/Documents/in/Heart_valves?f_ri=90514"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=90514"},{"id":382393,"name":"Neuropeptide Y","url":"https://www.academia.edu/Documents/in/Neuropeptide_Y?f_ri=90514"},{"id":392828,"name":"Myocardium","url":"https://www.academia.edu/Documents/in/Myocardium?f_ri=90514"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=90514"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=90514"},{"id":417494,"name":"Rat","url":"https://www.academia.edu/Documents/in/Rat?f_ri=90514"},{"id":436755,"name":"Degeneration","url":"https://www.academia.edu/Documents/in/Degeneration?f_ri=90514"},{"id":537759,"name":"Gastrointestinal Tract","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Tract?f_ri=90514"},{"id":564878,"name":"Body 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Group","url":"https://www.academia.edu/Documents/in/Control_Group?f_ri=90514"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=90514"},{"id":1944518,"name":"Alcian blue","url":"https://www.academia.edu/Documents/in/Alcian_blue?f_ri=90514"},{"id":2090674,"name":"Duodenum","url":"https://www.academia.edu/Documents/in/Duodenum?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18827805" data-work_id="18827805" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18827805/Dietary_fats_cholesterol_and_iron_as_risk_factors_for_Parkinsons_disease">Dietary fats, cholesterol and iron as risk factors for Parkinson's disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Epidemiologic findings suggest that dietary components may contribute to the etiology of Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (PD). This population-based case-control study evaluated PD risk... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18827805" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Epidemiologic findings suggest that dietary components may contribute to the etiology of Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (PD). This population-based case-control study evaluated PD risk and dietary intake of fats, cholesterol and iron. Newly diagnosed case (n=420) and age/gender/ethnicity-matched unrelated controls (n=560) were identified between 1992 and 2006 from the Group Health Cooperative health maintenance organization in western Washington State, and the University of Washington Neurology Clinic. In-person interviews elicited data on food frequency habits during most of adult life. Nutritional intakes were calculated and analyzed, with adjustments made for total energy intake (the &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;nutrition density&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; technique). Cholesterol intake in the highest quartile compared with the lowest quartile was associated with a decreased risk of PD in men (odds ratio (OR)=0.53, 95%CI: 0.33, 0.86). The highest versus the lowest quartile of dietary iron increased PD risk in men (OR=1.82, 95%CI: 1.11, 2.99). When the lowest quartile of cholesterol and the highest quartile for iron were compared to the highest quartile of cholesterol and the lowest quartile of iron, no association was seen in women, but for men PD risk was increased (OR=2.70, 95%CI: 1.26, 5.76). Saturated fat intake below the median in combination with iron intake above the median also increased the PD risk (OR=1.50, 95%CI: 1.07, 2.11) in both genders combined. A low intake of cholesterol, particularly in the presence of high iron, may be associated with an increased risk for PD.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18827805" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1b1e9c1d9e9808119eec1f4165e4aa2d" rel="nofollow" data-download="{"attachment_id":42133651,"asset_id":18827805,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42133651/download_file?st=MTczMjczMjg3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38917091" href="https://washington.academia.edu/TSmithweller">Terri Smith-weller</a><script data-card-contents-for-user="38917091" type="text/json">{"id":38917091,"first_name":"Terri","last_name":"Smith-weller","domain_name":"washington","page_name":"TSmithweller","display_name":"Terri Smith-weller","profile_url":"https://washington.academia.edu/TSmithweller?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18827805 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18827805"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18827805, container: ".js-paper-rank-work_18827805", }); 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This population-based case-control study evaluated PD risk and dietary intake of fats, cholesterol and iron. Newly diagnosed case (n=420) and age/gender/ethnicity-matched unrelated controls (n=560) were identified between 1992 and 2006 from the Group Health Cooperative health maintenance organization in western Washington State, and the University of Washington Neurology Clinic. In-person interviews elicited data on food frequency habits during most of adult life. Nutritional intakes were calculated and analyzed, with adjustments made for total energy intake (the \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;nutrition density\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; technique). Cholesterol intake in the highest quartile compared with the lowest quartile was associated with a decreased risk of PD in men (odds ratio (OR)=0.53, 95%CI: 0.33, 0.86). The highest versus the lowest quartile of dietary iron increased PD risk in men (OR=1.82, 95%CI: 1.11, 2.99). When the lowest quartile of cholesterol and the highest quartile for iron were compared to the highest quartile of cholesterol and the lowest quartile of iron, no association was seen in women, but for men PD risk was increased (OR=2.70, 95%CI: 1.26, 5.76). Saturated fat intake below the median in combination with iron intake above the median also increased the PD risk (OR=1.50, 95%CI: 1.07, 2.11) in both genders combined. A low intake of cholesterol, particularly in the presence of high iron, may be associated with an increased risk for PD.","downloadable_attachments":[{"id":42133651,"asset_id":18827805,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38917091,"first_name":"Terri","last_name":"Smith-weller","domain_name":"washington","page_name":"TSmithweller","display_name":"Terri Smith-weller","profile_url":"https://washington.academia.edu/TSmithweller?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=90514","nofollow":false},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514","nofollow":false},{"id":129744,"name":"Confidence 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Dietetics</a>, <script data-card-contents-for-ri="591" type="text/json">{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9478" href="https://www.academia.edu/Documents/in/Diet">Diet</a>, <script data-card-contents-for-ri="9478" type="text/json">{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47533" href="https://www.academia.edu/Documents/in/Dairy_Nutrition">Dairy Nutrition</a>, <script data-card-contents-for-ri="47533" type="text/json">{"id":47533,"name":"Dairy Nutrition","url":"https://www.academia.edu/Documents/in/Dairy_Nutrition?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="90514" href="https://www.academia.edu/Documents/in/Cholesterol">Cholesterol</a><script 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type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1907" href="https://www.academia.edu/Documents/in/Nutrition">Nutrition</a>, <script data-card-contents-for-ri="1907" type="text/json">{"id":1907,"name":"Nutrition","url":"https://www.academia.edu/Documents/in/Nutrition?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3227" href="https://www.academia.edu/Documents/in/Schizophrenia">Schizophrenia</a><script data-card-contents-for-ri="3227" type="text/json">{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17243809]'), work: {"id":17243809,"title":"Systematic review and meta-analysis of the effects of high protein 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class="u-tcGrayDark u-fw700" data-has-card-for-user="36838643" href="https://independent.academia.edu/FrankGreenway">Frank Greenway</a><script data-card-contents-for-user="36838643" type="text/json">{"id":36838643,"first_name":"Frank","last_name":"Greenway","domain_name":"independent","page_name":"FrankGreenway","display_name":"Frank Greenway","profile_url":"https://independent.academia.edu/FrankGreenway?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_79685219 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="79685219"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 79685219, container: ".js-paper-rank-work_79685219", }); });</script></li><li class="js-percentile-work_79685219 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span 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$(".js-view-count[data-work-id=79685219]").text(description); $(".js-view-count-work_79685219").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_79685219").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="79685219"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23890" href="https://www.academia.edu/Documents/in/Comparative_Study">Comparative Study</a>, <script data-card-contents-for-ri="23890" type="text/json">{"id":23890,"name":"Comparative Study","url":"https://www.academia.edu/Documents/in/Comparative_Study?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37905" href="https://www.academia.edu/Documents/in/Counseling">Counseling</a><script data-card-contents-for-ri="37905" type="text/json">{"id":37905,"name":"Counseling","url":"https://www.academia.edu/Documents/in/Counseling?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=79685219]'), work: {"id":79685219,"title":"Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates","created_at":"2022-05-22T17:33:36.464-07:00","url":"https://www.academia.edu/79685219/Comparison_of_Weight_Loss_Diets_with_Different_Compositions_of_Fat_Protein_and_Carbohydrates?f_ri=90514","dom_id":"work_79685219","summary":null,"downloadable_attachments":[{"id":86315265,"asset_id":79685219,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36838643,"first_name":"Frank","last_name":"Greenway","domain_name":"independent","page_name":"FrankGreenway","display_name":"Frank Greenway","profile_url":"https://independent.academia.edu/FrankGreenway?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=90514","nofollow":false},{"id":23890,"name":"Comparative 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Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=90514"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight?f_ri=90514"},{"id":1567539,"name":"Energy Intake","url":"https://www.academia.edu/Documents/in/Energy_Intake?f_ri=90514"},{"id":2348526,"name":"Dietary fats","url":"https://www.academia.edu/Documents/in/Dietary_fats?f_ri=90514"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=90514"},{"id":4059023,"name":"diet reducing","url":"https://www.academia.edu/Documents/in/diet_reducing?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70783613" data-work_id="70783613" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70783613/Prevalence_of_microalbuminuria_in_type_2_diabetic_patients_in_Karachi_Pakistan_a_multi_center_study">Prevalence of microalbuminuria in type 2 diabetic patients in Karachi: Pakistan: a multi-center study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">OBJECTIVE To determine the frequency of microalbuminuria and its associations in type-2 diabetic subjects attending diabetes centers/clinics across Karachi, Pakistan. METHODS Two thousand one hundred subjects with type-2 diabetes were... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70783613" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">OBJECTIVE To determine the frequency of microalbuminuria and its associations in type-2 diabetic subjects attending diabetes centers/clinics across Karachi, Pakistan. METHODS Two thousand one hundred subjects with type-2 diabetes were screened for microalbuminuria using Micral test strip II. A single screening test was performed in 25 diabetes centers/units in different districts of Karachi from January 2003 to December 2003. RESULTS The overall prevalence of microalbuminuria was 34%. Mean age of subjects was 53.1 years +/- 11.9 years, mean BMI was 25.8 +/- 4.1 and mean duration of diabetes was 8.8 +/- 5.21 years. Fifty seven percent were males and 43% females. Sixty two percent of the subjects had a systolic blood pressure &gt; or = 130 mmHg. Forty five percent had a family history of diabetes and 5% had a family history of hypertension. Univariate analyses demonstrated significant associations between microalbuminuria and age, duration of diabetes, male gender, smoking status, mic...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70783613" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2dc5e6a5b17b4851b52132dbebb2c78b" rel="nofollow" data-download="{"attachment_id":80387886,"asset_id":70783613,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/80387886/download_file?st=MTczMjczMjg4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="197703291" href="https://independent.academia.edu/MuhammadzafarIqbalHydrie">Muhammad zafar Iqbal Hydrie</a><script data-card-contents-for-user="197703291" type="text/json">{"id":197703291,"first_name":"Muhammad zafar Iqbal","last_name":"Hydrie","domain_name":"independent","page_name":"MuhammadzafarIqbalHydrie","display_name":"Muhammad zafar Iqbal Hydrie","profile_url":"https://independent.academia.edu/MuhammadzafarIqbalHydrie?f_ri=90514","photo":"https://0.academia-photos.com/197703291/59744467/47994235/s65_muhammad_zafar_iqbal.hydrie.png"}</script></span></span></li><li class="js-paper-rank-work_70783613 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70783613"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70783613, container: ".js-paper-rank-work_70783613", }); 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$(".js-view-count[data-work-id=70783613]").text(description); $(".js-view-count-work_70783613").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_70783613").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="70783613"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7361" href="https://www.academia.edu/Documents/in/Pakistan">Pakistan</a>, <script data-card-contents-for-ri="7361" type="text/json">{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71300" href="https://www.academia.edu/Documents/in/Blood_Glucose">Blood Glucose</a>, <script data-card-contents-for-ri="71300" type="text/json">{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71399" href="https://www.academia.edu/Documents/in/Hypertension">Hypertension</a>, <script data-card-contents-for-ri="71399" type="text/json">{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="75318" href="https://www.academia.edu/Documents/in/Smoking">Smoking</a><script data-card-contents-for-ri="75318" type="text/json">{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=70783613]'), work: {"id":70783613,"title":"Prevalence of microalbuminuria in type 2 diabetic patients in Karachi: Pakistan: a multi-center study","created_at":"2022-02-06T20:52:00.849-08:00","url":"https://www.academia.edu/70783613/Prevalence_of_microalbuminuria_in_type_2_diabetic_patients_in_Karachi_Pakistan_a_multi_center_study?f_ri=90514","dom_id":"work_70783613","summary":"OBJECTIVE To determine the frequency of microalbuminuria and its associations in type-2 diabetic subjects attending diabetes centers/clinics across Karachi, Pakistan. METHODS Two thousand one hundred subjects with type-2 diabetes were screened for microalbuminuria using Micral test strip II. A single screening test was performed in 25 diabetes centers/units in different districts of Karachi from January 2003 to December 2003. RESULTS The overall prevalence of microalbuminuria was 34%. Mean age of subjects was 53.1 years +/- 11.9 years, mean BMI was 25.8 +/- 4.1 and mean duration of diabetes was 8.8 +/- 5.21 years. Fifty seven percent were males and 43% females. Sixty two percent of the subjects had a systolic blood pressure \u0026gt; or = 130 mmHg. Forty five percent had a family history of diabetes and 5% had a family history of hypertension. Univariate analyses demonstrated significant associations between microalbuminuria and age, duration of diabetes, male gender, smoking status, mic...","downloadable_attachments":[{"id":80387886,"asset_id":70783613,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":197703291,"first_name":"Muhammad zafar Iqbal","last_name":"Hydrie","domain_name":"independent","page_name":"MuhammadzafarIqbalHydrie","display_name":"Muhammad zafar Iqbal Hydrie","profile_url":"https://independent.academia.edu/MuhammadzafarIqbalHydrie?f_ri=90514","photo":"https://0.academia-photos.com/197703291/59744467/47994235/s65_muhammad_zafar_iqbal.hydrie.png"}],"research_interests":[{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=90514","nofollow":false},{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose?f_ri=90514","nofollow":false},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=90514","nofollow":false},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=90514","nofollow":false},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":227299,"name":"Triglycerides","url":"https://www.academia.edu/Documents/in/Triglycerides?f_ri=90514"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=90514"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=90514"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=90514"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=90514"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=90514"},{"id":752559,"name":"Albuminuria","url":"https://www.academia.edu/Documents/in/Albuminuria?f_ri=90514"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus?f_ri=90514"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=90514"},{"id":3693190,"name":"mass Screening","url":"https://www.academia.edu/Documents/in/mass_Screening?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_68632323" data-work_id="68632323" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/68632323/Pet_ownership_and_risk_factors_for_cardiovascular_disease">Pet ownership and risk factors for cardiovascular disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To compare risk factors for cardiovascular disease in pet owners and non-owners. Accepted risk factors for cardiovascular disease were measured in 5741 participants attending a free, screening clinic at the Baker Medical Research... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_68632323" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To compare risk factors for cardiovascular disease in pet owners and non-owners. Accepted risk factors for cardiovascular disease were measured in 5741 participants attending a free, screening clinic at the Baker Medical Research Institute in Melbourne. Blood pressure, plasma cholesterol and triglyceride values were compared in pet owners (n = 784) and non-owners (n = 4957). Pet owners had significantly lower systolic blood pressure and plasma triglycerides than non-owners. In men, pet owners had significantly lower systolic but not diastolic blood pressure than non-owners, and significantly lower plasma triglyceride levels, and plasma cholesterol levels. In women over 40 years old, systolic but not diastolic pressure was significantly lower in pet owners and plasma triglycerides also tended to be lower. There were no differences in body mass index and self-reported smoking habits were similar, but pet owners reported that they took significantly more exercise than non-owners, and a...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/68632323" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0450aade16e8ae7050705c1ea55dfc27" rel="nofollow" data-download="{"attachment_id":79047855,"asset_id":68632323,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79047855/download_file?st=MTczMjczMjg4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="71159705" href="https://independent.academia.edu/warwickanderson1">warwick anderson</a><script data-card-contents-for-user="71159705" type="text/json">{"id":71159705,"first_name":"warwick","last_name":"anderson","domain_name":"independent","page_name":"warwickanderson1","display_name":"warwick anderson","profile_url":"https://independent.academia.edu/warwickanderson1?f_ri=90514","photo":"https://0.academia-photos.com/71159705/98171943/87277047/s65_warwick.anderson.png"}</script></span></span></li><li class="js-paper-rank-work_68632323 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="68632323"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 68632323, container: ".js-paper-rank-work_68632323", }); });</script></li><li class="js-percentile-work_68632323 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 68632323; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_68632323"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_68632323 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="68632323"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 68632323; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=68632323]").text(description); $(".js-view-count-work_68632323").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_68632323").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="68632323"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4307" href="https://www.academia.edu/Documents/in/Behavior">Behavior</a>, <script data-card-contents-for-ri="4307" type="text/json">{"id":4307,"name":"Behavior","url":"https://www.academia.edu/Documents/in/Behavior?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9478" href="https://www.academia.edu/Documents/in/Diet">Diet</a>, <script data-card-contents-for-ri="9478" type="text/json">{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37925" href="https://www.academia.edu/Documents/in/Ownership">Ownership</a>, <script data-card-contents-for-ri="37925" type="text/json">{"id":37925,"name":"Ownership","url":"https://www.academia.edu/Documents/in/Ownership?f_ri=90514","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="75318" href="https://www.academia.edu/Documents/in/Smoking">Smoking</a><script data-card-contents-for-ri="75318" type="text/json">{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=90514","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=68632323]'), work: {"id":68632323,"title":"Pet ownership and risk factors for cardiovascular disease","created_at":"2022-01-18T13:55:43.183-08:00","url":"https://www.academia.edu/68632323/Pet_ownership_and_risk_factors_for_cardiovascular_disease?f_ri=90514","dom_id":"work_68632323","summary":"To compare risk factors for cardiovascular disease in pet owners and non-owners. Accepted risk factors for cardiovascular disease were measured in 5741 participants attending a free, screening clinic at the Baker Medical Research Institute in Melbourne. Blood pressure, plasma cholesterol and triglyceride values were compared in pet owners (n = 784) and non-owners (n = 4957). Pet owners had significantly lower systolic blood pressure and plasma triglycerides than non-owners. In men, pet owners had significantly lower systolic but not diastolic blood pressure than non-owners, and significantly lower plasma triglyceride levels, and plasma cholesterol levels. In women over 40 years old, systolic but not diastolic pressure was significantly lower in pet owners and plasma triglycerides also tended to be lower. There were no differences in body mass index and self-reported smoking habits were similar, but pet owners reported that they took significantly more exercise than non-owners, and a...","downloadable_attachments":[{"id":79047855,"asset_id":68632323,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":71159705,"first_name":"warwick","last_name":"anderson","domain_name":"independent","page_name":"warwickanderson1","display_name":"warwick anderson","profile_url":"https://independent.academia.edu/warwickanderson1?f_ri=90514","photo":"https://0.academia-photos.com/71159705/98171943/87277047/s65_warwick.anderson.png"}],"research_interests":[{"id":4307,"name":"Behavior","url":"https://www.academia.edu/Documents/in/Behavior?f_ri=90514","nofollow":false},{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=90514","nofollow":false},{"id":37925,"name":"Ownership","url":"https://www.academia.edu/Documents/in/Ownership?f_ri=90514","nofollow":false},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=90514","nofollow":false},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=90514"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=90514"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise?f_ri=90514"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=90514"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=90514"},{"id":227299,"name":"Triglycerides","url":"https://www.academia.edu/Documents/in/Triglycerides?f_ri=90514"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=90514"},{"id":313857,"name":"Risk Factor","url":"https://www.academia.edu/Documents/in/Risk_Factor?f_ri=90514"},{"id":559242,"name":"Cardiovascular Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=90514"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=90514"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences?f_ri=90514"},{"id":2345130,"name":"Socioeconomic Factors","url":"https://www.academia.edu/Documents/in/Socioeconomic_Factors?f_ri=90514"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_68113898" data-work_id="68113898" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/68113898/Amyloid_%CE%B2_peptide_insertion_in_liposomes_containing_GM1_cholesterol_domains">Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neuronal membrane damage is related to the early impairments appearing in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_68113898" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neuronal membrane damage is related to the early impairments appearing in Alzheimer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease due to the interaction of the amyloid β-peptide (Aβ) with the phospholipid bilayer. In particular, the ganglioside GM1, present with cholesterol in lipid rafts, seems to be able to initiate Aβ aggregation on membrane. We studied the thermodynamic and structural effects of the presence of GM1 on the interaction between Aβ and liposomes, a good membrane model system. Isothermal Titration Calorimetry highlighted the importance of the presence of GM1 in recruiting monomeric Aβ toward the lipid bilayer. Light and Small Angle X-ray Scattering revealed a different pattern for GM1 containing liposomes, both before and after interaction with Aβ. The results suggest that the interaction with GM1 brings to insertion of Aβ in the bilayer, producing a structural perturbation down to the internal layers of the liposome, as demonstrated by the obtained electron density profiles.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/68113898" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="212350395" href="https://independent.academia.edu/dariospigolon">dario spigolon</a><script data-card-contents-for-user="212350395" type="text/json">{"id":212350395,"first_name":"dario","last_name":"spigolon","domain_name":"independent","page_name":"dariospigolon","display_name":"dario spigolon","profile_url":"https://independent.academia.edu/dariospigolon?f_ri=90514","photo":"https://0.academia-photos.com/212350395/71483825/59929230/s65_dario.spigolon.png"}</script></span></span></li><li class="js-paper-rank-work_68113898 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="68113898"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 68113898, container: ".js-paper-rank-work_68113898", }); 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In particular, the ganglioside GM1, present with cholesterol in lipid rafts, seems to be able to initiate Aβ aggregation on membrane. We studied the thermodynamic and structural effects of the presence of GM1 on the interaction between Aβ and liposomes, a good membrane model system. Isothermal Titration Calorimetry highlighted the importance of the presence of GM1 in recruiting monomeric Aβ toward the lipid bilayer. Light and Small Angle X-ray Scattering revealed a different pattern for GM1 containing liposomes, both before and after interaction with Aβ. 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class="clearfix u-pv7x u-mb0x js-work-card work_49389147" data-work_id="49389147" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49389147/The_metabolic_syndrome_among_patients_with_cardiovascular_disease_in_Accra_Ghana">The metabolic syndrome among patients with cardiovascular disease in Accra, Ghana</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There is evidence linking the Metabolic Syndrome with an increased risk of developing cardiovascular disease, previously thought to be rare in Africa but now a major public health concern. To determine the frequency of occurrence of the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49389147" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There is evidence linking the Metabolic Syndrome with an increased risk of developing cardiovascular disease, previously thought to be rare in Africa but now a major public health concern. To determine the frequency of occurrence of the Metabolic Syndrome among patients presenting with cardiovascular disease at the Korle Bu Teaching Hospital, Ghana. This was a case-control study of 100 consecutive cardiovascular disease patients and 100 age- and sex- matched controls who underwent an interview and physical examination. Anthropometric measurements and fasting blood samples for plasma glucose and lipids were taken. The National Cholesterol Education Programme: Adult Treatment Panel III criteria were used for the diagnosis of the Metabolic Syndrome. The prevalence of Metabolic Syndrome among cases and controls was 54% and 18% respectively, with the prevalence increasing with advancing age. Hypertension and central obesity were the two components with the highest frequency among individ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49389147" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="04e1b7358ee761f41539383c42e2f6e3" rel="nofollow" data-download="{"attachment_id":67756424,"asset_id":49389147,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67756424/download_file?st=MTczMjczMjg4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31314384" href="https://independent.academia.edu/josephineakpalu">josephine akpalu</a><script data-card-contents-for-user="31314384" type="text/json">{"id":31314384,"first_name":"josephine","last_name":"akpalu","domain_name":"independent","page_name":"josephineakpalu","display_name":"josephine akpalu","profile_url":"https://independent.academia.edu/josephineakpalu?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_49389147 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49389147"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49389147, container: ".js-paper-rank-work_49389147", }); 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class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The effects of the administration of 50 mg of guggulipid or placebo capsules twice daily for 24 weeks were compared as adjuncts to a fruit- and vegetable-enriched prudent diet in the management of 61 patients with hypercholesterolemia (31... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6409535" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The effects of the administration of 50 mg of guggulipid or placebo capsules twice daily for 24 weeks were compared as adjuncts to a fruit- and vegetable-enriched prudent diet in the management of 61 patients with hypercholesterolemia (31 in the guggulipid group and 30 in the placebo group) in a randomized, double-blind fashion. Guggulipid decreased the total cholesterol level by 11.7%, the low density lipoprotein cholesterol (LDL) by 12.5%, triglycerides by 12.0%, and the total cholesterol/high density lipoprotein (HDL) cholesterol ratio by 11.1% from the postdiet levels, whereas the levels were unchanged in the placebo group. The HDL cholesterol level showed no changes in the two groups. The lipid peroxides, indicating oxidative stress, declined 33.3% in the guggulipid group without any decrease in the placebo group. The compliance of patients was greater than 96%. The combined effect of diet and guggulipid at 36 weeks was as great as the reported lipid-lowering effect of modern drugs. After a washout period of another 12 weeks, changes in blood lipoproteins were reversed in the guggulipid group without such changes in the placebo group. Side effects of guggulipid were headache, mild nausea, eructation, and hiccup in a few patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6409535" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="74557b34e0a01d24c062a8605e50858c" rel="nofollow" data-download="{"attachment_id":48879862,"asset_id":6409535,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48879862/download_file?st=MTczMjczMjg4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="10080695" href="https://independent.academia.edu/ramsingh30">ram singh</a><script data-card-contents-for-user="10080695" type="text/json">{"id":10080695,"first_name":"ram","last_name":"singh","domain_name":"independent","page_name":"ramsingh30","display_name":"ram singh","profile_url":"https://independent.academia.edu/ramsingh30?f_ri=90514","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_6409535 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="6409535"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 6409535, container: ".js-paper-rank-work_6409535", }); 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Guggulipid decreased the total cholesterol level by 11.7%, the low density lipoprotein cholesterol (LDL) by 12.5%, triglycerides by 12.0%, and the total cholesterol/high density lipoprotein (HDL) cholesterol ratio by 11.1% from the postdiet levels, whereas the levels were unchanged in the placebo group. The HDL cholesterol level showed no changes in the two groups. The lipid peroxides, indicating oxidative stress, declined 33.3% in the guggulipid group without any decrease in the placebo group. The compliance of patients was greater than 96%. The combined effect of diet and guggulipid at 36 weeks was as great as the reported lipid-lowering effect of modern drugs. After a washout period of another 12 weeks, changes in blood lipoproteins were reversed in the guggulipid group without such changes in the placebo group. Side effects of guggulipid were headache, mild nausea, eructation, and hiccup in a few patients.","downloadable_attachments":[{"id":48879862,"asset_id":6409535,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":10080695,"first_name":"ram","last_name":"singh","domain_name":"independent","page_name":"ramsingh30","display_name":"ram singh","profile_url":"https://independent.academia.edu/ramsingh30?f_ri=90514","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":14292,"name":"Oxidative 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