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We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.Chronic" /> <meta name="twitter:image" content="https://0.academia-photos.com/1062479/367117/92340491/s200_dr._mohammed_abdul_hannan.hazari.png" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/1170112/Exposure_to_benzene_induces_oxidative_stress_alters_the_immune_response_and_expression_of_p53_in_gasoline_filling_workers" /> <meta property="og:title" content="Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="BackgroundChronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.Chronic" /> <meta property="article:author" content="https://deccancollegeofmedicalsciences.academia.edu/DrMohammedAbdulHannanHazari" /> <meta name="description" content="BackgroundChronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.Chronic" /> <title>(PDF) Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers | Dr. Mohammed Abdul Hannan Hazari - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/1170112/Exposure_to_benzene_induces_oxidative_stress_alters_the_immune_response_and_expression_of_p53_in_gasoline_filling_workers" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732524593000); window.Aedu.timeDifference = new Date().getTime() - 1732524593000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"BackgroundChronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.Chronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.MethodsFour hundred twenty-eight gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals were recruited for this study. Benzene concentration was determined by gas chromatography, reactive oxygen species (ROS) by dichlorofluorescin diacetate (DCFH-DA) method, malondialdehyde (MDA) by thiobarbituric acid reactive substances assay (TBARS), total superoxide dismutase (T-SOD) by RANSOD kit and glutathione (GSH) by 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) reaction, respectively. CD4, CD8, IgG were carried out by using fluorescence activated cell sorter (FACS Calibur) and mRNA expression of p53 by reverse transcriptase PCR (RT-PCR).Four hundred twenty-eight gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals were recruited for this study. Benzene concentration was determined by gas chromatography, reactive oxygen species (ROS) by dichlorofluorescin diacetate (DCFH-DA) method, malondialdehyde (MDA) by thiobarbituric acid reactive substances assay (TBARS), total superoxide dismutase (T-SOD) by RANSOD kit and glutathione (GSH) by 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) reaction, respectively. CD4, CD8, IgG were carried out by using fluorescence activated cell sorter (FACS Calibur) and mRNA expression of p53 by reverse transcriptase PCR (RT-PCR).ResultsA significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. The levels of ROS and MDA were significantly elevated, and GSH and total T-SOD were decreased in the workers compared with the controls. A statistically significant decrease in the immunoglobulin levels, CD4T cells, CD4/CD8 ratio was observed in workers (vs. controls), whereas no significant difference was observed in CD8T cells. p53 gene expression was markedly higher in workers than in controls.A significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. The levels of ROS and MDA were significantly elevated, and GSH and total T-SOD were decreased in the workers compared with the controls. A statistically significant decrease in the immunoglobulin levels, CD4T cells, CD4/CD8 ratio was observed in workers (vs. controls), whereas no significant difference was observed in CD8T cells. p53 gene expression was markedly higher in workers than in controls.ConclusionOccupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard. Am. J. Ind. Med. 53:1264–1270, 2010. © 2010 Wiley-Liss, Inc.Occupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard. Am. J. Ind. Med. 53:1264–1270, 2010. © 2010 Wiley-Liss, Inc.","author":[{"@context":"https://schema.org","@type":"Person","name":"Dr. Mohammed Abdul Hannan Hazari"}],"contributor":[],"dateCreated":"2011-12-20","dateModified":"2015-07-15","datePublished":"2010-12-01","headline":"Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers","inLanguage":"en","keywords":["Oxidative Stress","Benzene toxicity"],"locationCreated":null,"publication":"American Journal of Industrial Medicine","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Wiley Online Library"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/1170112/Exposure_to_benzene_induces_oxidative_stress_alters_the_immune_response_and_expression_of_p53_in_gasoline_filling_workers","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"deccancollegeofmedicalsciences"}]}</script><link rel="stylesheet" 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{"work":{"id":1170112,"created_at":"2011-12-20T17:08:33.974-08:00","from_world_paper_id":14475021,"updated_at":"2021-01-14T20:16:35.691-08:00","_data":{"abstract":"BackgroundChronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.Chronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.MethodsFour hundred twenty-eight gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals were recruited for this study. Benzene concentration was determined by gas chromatography, reactive oxygen species (ROS) by dichlorofluorescin diacetate (DCFH-DA) method, malondialdehyde (MDA) by thiobarbituric acid reactive substances assay (TBARS), total superoxide dismutase (T-SOD) by RANSOD kit and glutathione (GSH) by 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) reaction, respectively. CD4, CD8, IgG were carried out by using fluorescence activated cell sorter (FACS Calibur) and mRNA expression of p53 by reverse transcriptase PCR (RT-PCR).Four hundred twenty-eight gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals were recruited for this study. Benzene concentration was determined by gas chromatography, reactive oxygen species (ROS) by dichlorofluorescin diacetate (DCFH-DA) method, malondialdehyde (MDA) by thiobarbituric acid reactive substances assay (TBARS), total superoxide dismutase (T-SOD) by RANSOD kit and glutathione (GSH) by 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) reaction, respectively. CD4, CD8, IgG were carried out by using fluorescence activated cell sorter (FACS Calibur) and mRNA expression of p53 by reverse transcriptase PCR (RT-PCR).ResultsA significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. The levels of ROS and MDA were significantly elevated, and GSH and total T-SOD were decreased in the workers compared with the controls. A statistically significant decrease in the immunoglobulin levels, CD4T cells, CD4/CD8 ratio was observed in workers (vs. controls), whereas no significant difference was observed in CD8T cells. p53 gene expression was markedly higher in workers than in controls.A significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. The levels of ROS and MDA were significantly elevated, and GSH and total T-SOD were decreased in the workers compared with the controls. A statistically significant decrease in the immunoglobulin levels, CD4T cells, CD4/CD8 ratio was observed in workers (vs. controls), whereas no significant difference was observed in CD8T cells. p53 gene expression was markedly higher in workers than in controls.ConclusionOccupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard. Am. J. Ind. Med. 53:1264–1270, 2010. © 2010 Wiley-Liss, Inc.Occupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard. Am. J. Ind. Med. 53:1264–1270, 2010. © 2010 Wiley-Liss, Inc.","publisher":"Wiley Online Library","publication_date":"2010,12,1","publication_name":"American Journal of Industrial Medicine"},"document_type":"paper","pre_hit_view_count_baseline":8,"quality":"high","language":"en","title":"Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [1062479]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":7216704,"attachmentType":"pdf"}"><img alt="First page of “Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/7216704/mini_magick20190427-2575-1ryrq82.png?1556365598" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="1062479" href="https://deccancollegeofmedicalsciences.academia.edu/DrMohammedAbdulHannanHazari"><img alt="Profile image of Dr. Mohammed Abdul Hannan Hazari" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/1062479/367117/92340491/s65_dr._mohammed_abdul_hannan.hazari.png" />Dr. Mohammed Abdul Hannan Hazari</a></div><p class="ds-work-card--detail ds2-5-body-sm">2010, American Journal of Industrial Medicine</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">BackgroundChronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.Chronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.MethodsFour hundred twenty-eight gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals were recruited for this study. Benzene concentration was determined by gas chromatography, reactive oxygen species (ROS) by dichlorofluorescin diacetate (DCFH-DA) method, malondialdehyde (MDA) by thiobarbituric acid reactive substances assay (TBARS), total superoxide dismutase (T-SOD) by RANSOD kit and glutathione (GSH) by 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) reaction, respectively. CD4, CD8, IgG were carried out by using fluorescence activated cell sorter (FACS Calibur) and mRNA expression of p53 by reverse transcriptase PCR (RT-PCR).Four hundred twenty-eight gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals were recruited for this study. Benzene concentration was determined by gas chromatography, reactive oxygen species (ROS) by dichlorofluorescin diacetate (DCFH-DA) method, malondialdehyde (MDA) by thiobarbituric acid reactive substances assay (TBARS), total superoxide dismutase (T-SOD) by RANSOD kit and glutathione (GSH) by 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) reaction, respectively. CD4, CD8, IgG were carried out by using fluorescence activated cell sorter (FACS Calibur) and mRNA expression of p53 by reverse transcriptase PCR (RT-PCR).ResultsA significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. The levels of ROS and MDA were significantly elevated, and GSH and total T-SOD were decreased in the workers compared with the controls. A statistically significant decrease in the immunoglobulin levels, CD4T cells, CD4/CD8 ratio was observed in workers (vs. controls), whereas no significant difference was observed in CD8T cells. p53 gene expression was markedly higher in workers than in controls.A significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. The levels of ROS and MDA were significantly elevated, and GSH and total T-SOD were decreased in the workers compared with the controls. A statistically significant decrease in the immunoglobulin levels, CD4T cells, CD4/CD8 ratio was observed in workers (vs. controls), whereas no significant difference was observed in CD8T cells. p53 gene expression was markedly higher in workers than in controls.ConclusionOccupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard. Am. J. Ind. Med. 53:1264–1270, 2010. © 2010 Wiley-Liss, Inc.Occupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard. Am. J. Ind. Med. 53:1264–1270, 2010. © 2010 Wiley-Liss, Inc.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":7216704,"attachmentType":"pdf","workUrl":"https://www.academia.edu/1170112/Exposure_to_benzene_induces_oxidative_stress_alters_the_immune_response_and_expression_of_p53_in_gasoline_filling_workers"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":7216704,"attachmentType":"pdf","workUrl":"https://www.academia.edu/1170112/Exposure_to_benzene_induces_oxidative_stress_alters_the_immune_response_and_expression_of_p53_in_gasoline_filling_workers"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="7216704" data-landing_url="https://www.academia.edu/1170112/Exposure_to_benzene_induces_oxidative_stress_alters_the_immune_response_and_expression_of_p53_in_gasoline_filling_workers" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="12475685" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12475685/Early_hematological_and_immunological_alterations_in_gasoline_station_attendants_exposed_to_benzene">Early hematological and immunological alterations in gasoline station attendants exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31315301" href="https://fiocruz.academia.edu/FFreitas">Fernando Freitas</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Research, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Early hematological and immunological alterations in gasoline station attendants exposed to benzene","attachmentId":46155826,"attachmentType":"pdf","work_url":"https://www.academia.edu/12475685/Early_hematological_and_immunological_alterations_in_gasoline_station_attendants_exposed_to_benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12475685/Early_hematological_and_immunological_alterations_in_gasoline_station_attendants_exposed_to_benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="16440264" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16440264/Study_of_some_immunological_parameters_in_workers_occupationally_exposed_to_benzene">Study of some immunological parameters in workers occupationally exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35609793" href="https://independent.academia.edu/MZavali%C4%87">M. 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Turk</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Archives of Occupational and Environmental Health, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Study of some immunological parameters in workers occupationally exposed to benzene","attachmentId":42479229,"attachmentType":"pdf","work_url":"https://www.academia.edu/16440264/Study_of_some_immunological_parameters_in_workers_occupationally_exposed_to_benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16440264/Study_of_some_immunological_parameters_in_workers_occupationally_exposed_to_benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="18474095" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers">An Epidemiologic Study of Early Biologic Effects of Benzene in Chinese Workers</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38486006" href="https://independent.academia.edu/JosephWiemels">Joseph Wiemels</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health Perspectives, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"An Epidemiologic Study of Early Biologic Effects of Benzene in Chinese Workers","attachmentId":40082461,"attachmentType":"pdf","work_url":"https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="54008333" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54008333/Environmental_Assessment_and_Evaluation_of_Oxidative_Stress_and_Genotoxicity_Biomarkers_Related_to_Chronic_Occupational_Exposure_to_Benzene">Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="118142759" href="https://independent.academia.edu/RitaMattos2">Rita Mattos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Environmental Research and Public Health</p><p class="ds-related-work--abstract ds2-5-body-sm">Environmental and occupational exposure to benzene from fuels is a major cause for concern for national and international authorities, as benzene is a known carcinogen in humans and there is no safe limit for exposure to carcinogens. The objective of this study was to evaluate the genotoxic effects of chronic occupational exposure to benzene among two groups of workers: filling station workers (Group I) and security guards working at vehicles entrances (Group II), both on the same busy highway in Rio de Janeiro, Brazil. Sociodemographic data on the workers were evaluated; the concentration of benzene/toluene (B/T) in atmospheric air and individual trans,trans-muconic acid (ttMA) and S-phenylmercapturic acid (S-PMA) were measured; oxidative stress was analyzed by catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD), thiol groups (THIOL) and malondialdehyde (MDA); genotoxicity was measured by metaphases with chromosomal abnormalities (MCA) and nuclear abnormalit...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene","attachmentId":70579769,"attachmentType":"pdf","work_url":"https://www.academia.edu/54008333/Environmental_Assessment_and_Evaluation_of_Oxidative_Stress_and_Genotoxicity_Biomarkers_Related_to_Chronic_Occupational_Exposure_to_Benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/54008333/Environmental_Assessment_and_Evaluation_of_Oxidative_Stress_and_Genotoxicity_Biomarkers_Related_to_Chronic_Occupational_Exposure_to_Benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="56274929" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56274929/Phenotype_analysis_of_lymphocytes_of_workers_with_chronic_benzene_poisoning">Phenotype analysis of lymphocytes of workers with chronic benzene poisoning</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33084143" href="https://ufba.academia.edu/RMeyer">Roberto Meyer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Immunology Letters, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Phenotype analysis of lymphocytes of workers with chronic benzene poisoning","attachmentId":71742492,"attachmentType":"pdf","work_url":"https://www.academia.edu/56274929/Phenotype_analysis_of_lymphocytes_of_workers_with_chronic_benzene_poisoning","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/56274929/Phenotype_analysis_of_lymphocytes_of_workers_with_chronic_benzene_poisoning"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="124315521" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/124315521/Effect_of_Benzene_Exposure_on_Ferritin_and_Complete_Blood_Count_in_OiLibya420_Gas_Station_Workers">Effect of Benzene Exposure on Ferritin and Complete Blood Count in OiLibya420 Gas Station Workers</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="96873102" href="https://independent.academia.edu/hudamohamed23">huda mohamed</a></div><p class="ds-related-work--abstract ds2-5-body-sm">ABSTRACT: Benzene is a colorless liquid that easily evaporates in the air and can lead to negative impacts on the workers’ health. Also, it can cause cancer. This study aimed to evaluate the effect of benzene on the ferritin level and blood of workers in petrol station. This study has a cross sectional design. It includes 32 participants out of which 16 are exposed workers and 16 non exposed ones. The data was collected by using a questionnaire about socio-demographic characteristics and symptoms of benzene exposure. Also, Blood samples were taken to test ferritin and complete blood counts and analyzed by using Statistical Package for Social Sciences. The results of the study revealed that exposure to benzene in some workers leads to decreasing serum ferritin, MCV, MXD and MCH, and increased WBC, RBC, and HCT. There was a statistical difference in the WBC, RBC, MCV, MCH, LYM, and MXD between the exposed and non-exposed groups. There was a positive relationship between years of experience and effects of benzene on WBC, and a clear correlation between the exposed workers’ age, HGB and ferritin levels. Benzene has negative impacts on the health of workers, which dictates the necessity of worker wearing personal protective equipment in the workplace.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Benzene Exposure on Ferritin and Complete Blood Count in OiLibya420 Gas Station Workers","attachmentId":118564861,"attachmentType":"pdf","work_url":"https://www.academia.edu/124315521/Effect_of_Benzene_Exposure_on_Ferritin_and_Complete_Blood_Count_in_OiLibya420_Gas_Station_Workers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/124315521/Effect_of_Benzene_Exposure_on_Ferritin_and_Complete_Blood_Count_in_OiLibya420_Gas_Station_Workers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="4244745" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4244745/Hematological_changes_among_Chinese_workers_with_a_broad_range_of_benzene_exposures">Hematological changes among Chinese workers with a broad range of benzene exposures</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5140385" href="https://independent.academia.edu/HeyiLi">Heyi Li</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Industrial Medicine, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">BackgroundDepression of peripheral blood cells is a well-known indicator of benzene hematotoxicity. Previous studies of its effects on specific types of blood cells have yielded inconsistent results. We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China.Depression of peripheral blood cells is a well-known indicator of benzene hematotoxicity. Previous studies of its effects on specific types of blood cells have yielded inconsistent results. We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China.MethodsPersonal benzene exposures were sampled with 3-M organic vapor monitors, and analyzed by gas chromatography. The peripheral blood cells were counted by a cell counter. The WBC differential was manually counted on a total of 900 cells by a US commercial laboratory.Personal benzene exposures were sampled with 3-M organic vapor monitors, and analyzed by gas chromatography. The peripheral blood cells were counted by a cell counter. The WBC differential was manually counted on a total of 900 cells by a US commercial laboratory.ResultsA total of 130 exposed workers and 51 age- and gender-matched unexposed subjects were recruited in this study. Benzene exposure levels monitored on the day of biological sample collection for exposed workers ranged from 0.06 to 122 ppm. Their 4-week average and cumulative benzene exposure levels were 0.08–54.5 ppm and 6.1–623.2 ppm-years, respectively. Significant decreases of red blood cells (RBC), white blood cells (WBC), and neutrophils were observed and correlated with both personal benzene exposures and levels of urinary metabolites (S-phenylmercapuric acid and t,t-muconic acid) and albumin adducts of benzene oxide and 1,4-benzeoquinone.A total of 130 exposed workers and 51 age- and gender-matched unexposed subjects were recruited in this study. Benzene exposure levels monitored on the day of biological sample collection for exposed workers ranged from 0.06 to 122 ppm. Their 4-week average and cumulative benzene exposure levels were 0.08–54.5 ppm and 6.1–623.2 ppm-years, respectively. Significant decreases of red blood cells (RBC), white blood cells (WBC), and neutrophils were observed and correlated with both personal benzene exposures and levels of urinary metabolites (S-phenylmercapuric acid and t,t-muconic acid) and albumin adducts of benzene oxide and 1,4-benzeoquinone.ConclusionsThe depressions in RBC, WBC, and neutrophils observed in this study are not only exposure dependent, but also significantly different in the lowest exposed group (at or below 0.25 ppm) compared with unexposed subjects. The results of the present study appear to suggest that lymphocytes may not be more sensitive to chronic benzene exposure than neutrophils. Am. J. Ind. Med. 42:275–285, 2002. © 2002 Wiley-Liss, Inc.The depressions in RBC, WBC, and neutrophils observed in this study are not only exposure dependent, but also significantly different in the lowest exposed group (at or below 0.25 ppm) compared with unexposed subjects. The results of the present study appear to suggest that lymphocytes may not be more sensitive to chronic benzene exposure than neutrophils. Am. J. Ind. Med. 42:275–285, 2002. © 2002 Wiley-Liss, Inc.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hematological changes among Chinese workers with a broad range of benzene exposures","attachmentId":49974566,"attachmentType":"pdf","work_url":"https://www.academia.edu/4244745/Hematological_changes_among_Chinese_workers_with_a_broad_range_of_benzene_exposures","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4244745/Hematological_changes_among_Chinese_workers_with_a_broad_range_of_benzene_exposures"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="17834212" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17834212/DNA_damage_in_lymphocytes_of_benzene_exposed_workers_correlates_with_trans_trans_muconic_acids_and_breath_benzene_levels">DNA damage in lymphocytes of benzene exposed workers correlates with trans,trans-muconic acids and breath benzene levels</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37861759" href="https://independent.academia.edu/SKang4">S. Kang</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39303370" href="https://independent.academia.edu/HyungsikKang">Hyung-sik Kang</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37753021" href="https://independent.academia.edu/DonggeunSul">Donggeun Sul</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2005</p><p class="ds-related-work--abstract ds2-5-body-sm">Benzene causes many kinds of blood disorders in workers employed in many different environments. These diseases include myelodisplastic syndrome and acute and chronic myelocytic leukemia. In the present study, five occupational work places, including six industrial process types, namely, printing, shoe-making, methylene di-aniline (MDA), nitrobenzene, carbomer, and benzene production were selected, and the levels of breath benzene, and trans,trans-muconic acids (t,t-MA) and phenol in urine were evaluated, as well as hematological changes and lymphocyte DNA damage. The concentration of benzene in breath was less than 3 ppm in the workplaces, and benzene exposure was found to be higher in work places where benzene is used, than in those where benzene is produced. At low levels of benzene exposure, urinary t,t-MA correlated strongly with benzene in air. Highest Olive tail moments were found in workers producing carbomer. Levels of breathzone benzene were found to be strongly correlated with Olive tail moment values in the lymphocytes of workers, but not with hematological data in the six workplaces types. In conclusion, the highest benzene exposures found occurred in workers at a company, which utilized benzene in the production of carbomer. In terms of low levels of exposure to benzene, urinary t,t-MA and DNA damage exhibited a strong correlation with breath benzene, but not with hematological data. We conclude that breath benzene, t,t-MA and lymphocytic DNA damage are satisfactory biomonitoring markers with respect to benzene exposure in the workplace.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"DNA damage in lymphocytes of benzene exposed workers correlates with trans,trans-muconic acids and breath benzene levels","attachmentId":42224096,"attachmentType":"pdf","work_url":"https://www.academia.edu/17834212/DNA_damage_in_lymphocytes_of_benzene_exposed_workers_correlates_with_trans_trans_muconic_acids_and_breath_benzene_levels","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17834212/DNA_damage_in_lymphocytes_of_benzene_exposed_workers_correlates_with_trans_trans_muconic_acids_and_breath_benzene_levels"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="12478255" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12478255/Low_air_levels_of_benzene_Correlation_between_biomarkers_of_exposure_and_genotoxic_effects">Low air levels of benzene: Correlation between biomarkers of exposure and genotoxic effects</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31324191" href="https://independent.academia.edu/PieroLovreglio">Piero Lovreglio</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Toxicology Letters, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Low air levels of benzene: Correlation between biomarkers of exposure and genotoxic effects","attachmentId":46153583,"attachmentType":"pdf","work_url":"https://www.academia.edu/12478255/Low_air_levels_of_benzene_Correlation_between_biomarkers_of_exposure_and_genotoxic_effects","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12478255/Low_air_levels_of_benzene_Correlation_between_biomarkers_of_exposure_and_genotoxic_effects"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="77316337" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/77316337/In_vitro_and_in_vivo_evaluation_of_toxic_effect_of_benzene_on_lymphocytes_and_hepatocytes">In vitro and in vivo evaluation of toxic effect of benzene on lymphocytes and hepatocytes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="221618150" href="https://independent.academia.edu/naziauzma">nazia uzma</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Internet Journal of Toxicology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"In vitro and in vivo evaluation of toxic effect of benzene on lymphocytes and hepatocytes","attachmentId":84724957,"attachmentType":"pdf","work_url":"https://www.academia.edu/77316337/In_vitro_and_in_vivo_evaluation_of_toxic_effect_of_benzene_on_lymphocytes_and_hepatocytes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/77316337/In_vitro_and_in_vivo_evaluation_of_toxic_effect_of_benzene_on_lymphocytes_and_hepatocytes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas 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