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window.loswp.work = {"work":{"id":56274929,"created_at":"2021-10-07T04:58:47.726-07:00","from_world_paper_id":177247920,"updated_at":"2024-11-26T11:17:19.496-08:00","_data":{"publisher":"Elsevier BV","grobid_abstract":"Lifetime exposure to benzene is associated to a variety of blood disorders, and except for the risk of cancer, almost nothing is known concerning health impairment in individuals who are no longer exposed. In Brazil, this exposure is one of the serious problems in workplaces, and many workers have been laid off their jobs due to this intoxication, particularly in the State of Bahia, the largest producer of benzene in Latin America, which is the area of this study. From a larger study to describe health effects and genetic polymorphisms among workers with chronic benzene poisoning (CBP), this previous specific investigation analyzes the association between CBP and the pattern of sub-populations of lymphocytes. The study was performed with a CBP group (n = 24) and a control group with other occupational diseases (n = 24); both were selected at the Workers Health Study Center in the State of Bahia, Brazil. Clinical and epidemiologic variables were collected from medical records and from a detailed questionnaire. The average age was similar in the two groups (51.1 and 50.7, respectively). Analyzing the mean proportions of the sub-populations of lymphocytes, statistically significant differences were found for T cytotoxic cells (TCD8) (27.9; 19.4; p = 0.002) and T helper memory cell (CD4CD45RO) (31.2; 37.0; p = 0.015), respectively, for the CBP group and control group. These results should be viewed with caution because of the small sample size, but they strengthen a previous impression that workers exposed to benzene have their immune system impaired, even in the long term, which may contribute to some disorders and carcinogenesis process. These workers must be strictly followed up in a medical surveillance program. Although this problem has been known for a long time, this is the first attempt to study these specific effects in Brazil.","publication_date":"2005,,","publication_name":"Immunology Letters","grobid_abstract_attachment_id":"71742492"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Phenotype analysis of lymphocytes of workers with chronic benzene poisoning","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [33084143]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":71742492,"attachmentType":"pdf"}"><img alt="First page of “Phenotype analysis of lymphocytes of workers with chronic benzene poisoning”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/71742492/mini_magick20211007-24725-1ix899.png?1633610272" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Phenotype analysis of lymphocytes of workers with chronic benzene poisoning</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="33084143" href="https://ufba.academia.edu/RMeyer"><img alt="Profile image of Roberto Meyer" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Roberto Meyer</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2005, Immunology Letters</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">6 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 56274929; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Lifetime exposure to benzene is associated to a variety of blood disorders, and except for the risk of cancer, almost nothing is known concerning health impairment in individuals who are no longer exposed. In Brazil, this exposure is one of the serious problems in workplaces, and many workers have been laid off their jobs due to this intoxication, particularly in the State of Bahia, the largest producer of benzene in Latin America, which is the area of this study. From a larger study to describe health effects and genetic polymorphisms among workers with chronic benzene poisoning (CBP), this previous specific investigation analyzes the association between CBP and the pattern of sub-populations of lymphocytes. The study was performed with a CBP group (n = 24) and a control group with other occupational diseases (n = 24); both were selected at the Workers Health Study Center in the State of Bahia, Brazil. Clinical and epidemiologic variables were collected from medical records and from a detailed questionnaire. The average age was similar in the two groups (51.1 and 50.7, respectively). Analyzing the mean proportions of the sub-populations of lymphocytes, statistically significant differences were found for T cytotoxic cells (TCD8) (27.9; 19.4; p = 0.002) and T helper memory cell (CD4CD45RO) (31.2; 37.0; p = 0.015), respectively, for the CBP group and control group. These results should be viewed with caution because of the small sample size, but they strengthen a previous impression that workers exposed to benzene have their immune system impaired, even in the long term, which may contribute to some disorders and carcinogenesis process. These workers must be strictly followed up in a medical surveillance program. Although this problem has been known for a long time, this is the first attempt to study these specific effects in Brazil.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":71742492,"attachmentType":"pdf","workUrl":"https://www.academia.edu/56274929/Phenotype_analysis_of_lymphocytes_of_workers_with_chronic_benzene_poisoning"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":71742492,"attachmentType":"pdf","workUrl":"https://www.academia.edu/56274929/Phenotype_analysis_of_lymphocytes_of_workers_with_chronic_benzene_poisoning"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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Zavalić</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35679817" href="https://independent.academia.edu/RTurk1">R. Turk</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Archives of Occupational and Environmental Health, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Study of some immunological parameters in workers occupationally exposed to benzene","attachmentId":42479229,"attachmentType":"pdf","work_url":"https://www.academia.edu/16440264/Study_of_some_immunological_parameters_in_workers_occupationally_exposed_to_benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16440264/Study_of_some_immunological_parameters_in_workers_occupationally_exposed_to_benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="18474095" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers">An Epidemiologic Study of Early Biologic Effects of Benzene in Chinese Workers</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38486006" href="https://independent.academia.edu/JosephWiemels">Joseph Wiemels</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health Perspectives, 1996</p><p class="ds-related-work--abstract ds2-5-body-sm">Benzene is a recognized hematotoxin and leukemogen, but its mechanisms of action in humans are still uncertain. To provide insight into these processes, we carried out a cross-sectional study of 44 healthy workers currently exposed to benzene (median 8-hr time-weighted average; 31 ppm), and unexposed controls in Shanghai, China. Here we provide an overview of the study results on peripheral blood cell levels and somatic cell mutation frequency measured by the glycophorin A (GPA) gene loss assay and report on peripheral cytokine levels. All peripheral blood cell levels (i.e., total white blood cells, absolute lymphocyte count, platelets, red blood cells, and hemoglobin) were decreased among exposed workers compared to controls, with the exception of the red blood cell mean corpuscular volume, which was higher among exposed subjects. In contrast, peripheral cytokine levels (interleukin-3, interleukin-6, erythropoietin, granulocyte colonystimulating factor, tissue necrosis factor-a) in a subset of the most highly exposed workers (n = 11) were similar to values in controls (n = 11), suggesting that benzene does not affect these growth factor levels in peripheral blood. The GPA assay measures stem cell or precursor erythroid cell mutations expressed in peripheral red blood cells of MN heterozygous subjects, identifying NN variants, which result from loss of the GPA M allele and duplication of the N allele, and No variants, which arise from gene inactivation. The NN (but not NO) GPA variant cell frequency was elevated in the exposed workers compared with controls (mean ± SD, 13.9 ± 8.4 mutants per million cells versus 7.4 ± 5.2 per million cells, respectively; p=0.0002), suggesting that benzene produces gene-duplicating but not gene-inactivating mutations at the GPA locus in bone marrow cells of exposed humans. These findings, combined with ongoing analyses of benzene macromolecular adducts and chromosomal aberrations, will provide an opportunity to comprehensively evaluate a wide range of early biologic effects associated with benzene exposure in humans.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"An Epidemiologic Study of Early Biologic Effects of Benzene in Chinese Workers","attachmentId":40082461,"attachmentType":"pdf","work_url":"https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="122046871" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/122046871/Leukemia_Mortality_among_Benzene_Exposed_Workers_in_Brazil_2006_2011">Leukemia Mortality among Benzene-Exposed Workers in Brazil (2006-2011</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2440924" href="https://independent.academia.edu/MariaJulianaCorr%C3%AAa">Maria Juliana Corrêa</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Int J Environ Res Public Health, 2023</p><p class="ds-related-work--abstract ds2-5-body-sm">This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Leukemia Mortality among Benzene-Exposed Workers in Brazil (2006-2011","attachmentId":116787350,"attachmentType":"pdf","work_url":"https://www.academia.edu/122046871/Leukemia_Mortality_among_Benzene_Exposed_Workers_in_Brazil_2006_2011","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/122046871/Leukemia_Mortality_among_Benzene_Exposed_Workers_in_Brazil_2006_2011"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="4244745" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4244745/Hematological_changes_among_Chinese_workers_with_a_broad_range_of_benzene_exposures">Hematological changes among Chinese workers with a broad range of benzene exposures</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5140385" href="https://independent.academia.edu/HeyiLi">Heyi Li</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Industrial Medicine, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">BackgroundDepression of peripheral blood cells is a well-known indicator of benzene hematotoxicity. Previous studies of its effects on specific types of blood cells have yielded inconsistent results. We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China.Depression of peripheral blood cells is a well-known indicator of benzene hematotoxicity. Previous studies of its effects on specific types of blood cells have yielded inconsistent results. We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China.MethodsPersonal benzene exposures were sampled with 3-M organic vapor monitors, and analyzed by gas chromatography. The peripheral blood cells were counted by a cell counter. The WBC differential was manually counted on a total of 900 cells by a US commercial laboratory.Personal benzene exposures were sampled with 3-M organic vapor monitors, and analyzed by gas chromatography. The peripheral blood cells were counted by a cell counter. The WBC differential was manually counted on a total of 900 cells by a US commercial laboratory.ResultsA total of 130 exposed workers and 51 age- and gender-matched unexposed subjects were recruited in this study. Benzene exposure levels monitored on the day of biological sample collection for exposed workers ranged from 0.06 to 122 ppm. Their 4-week average and cumulative benzene exposure levels were 0.08–54.5 ppm and 6.1–623.2 ppm-years, respectively. Significant decreases of red blood cells (RBC), white blood cells (WBC), and neutrophils were observed and correlated with both personal benzene exposures and levels of urinary metabolites (S-phenylmercapuric acid and t,t-muconic acid) and albumin adducts of benzene oxide and 1,4-benzeoquinone.A total of 130 exposed workers and 51 age- and gender-matched unexposed subjects were recruited in this study. Benzene exposure levels monitored on the day of biological sample collection for exposed workers ranged from 0.06 to 122 ppm. Their 4-week average and cumulative benzene exposure levels were 0.08–54.5 ppm and 6.1–623.2 ppm-years, respectively. Significant decreases of red blood cells (RBC), white blood cells (WBC), and neutrophils were observed and correlated with both personal benzene exposures and levels of urinary metabolites (S-phenylmercapuric acid and t,t-muconic acid) and albumin adducts of benzene oxide and 1,4-benzeoquinone.ConclusionsThe depressions in RBC, WBC, and neutrophils observed in this study are not only exposure dependent, but also significantly different in the lowest exposed group (at or below 0.25 ppm) compared with unexposed subjects. The results of the present study appear to suggest that lymphocytes may not be more sensitive to chronic benzene exposure than neutrophils. Am. J. Ind. Med. 42:275–285, 2002. © 2002 Wiley-Liss, Inc.The depressions in RBC, WBC, and neutrophils observed in this study are not only exposure dependent, but also significantly different in the lowest exposed group (at or below 0.25 ppm) compared with unexposed subjects. The results of the present study appear to suggest that lymphocytes may not be more sensitive to chronic benzene exposure than neutrophils. Am. J. Ind. Med. 42:275–285, 2002. © 2002 Wiley-Liss, Inc.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hematological changes among Chinese workers with a broad range of benzene exposures","attachmentId":49974566,"attachmentType":"pdf","work_url":"https://www.academia.edu/4244745/Hematological_changes_among_Chinese_workers_with_a_broad_range_of_benzene_exposures","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4244745/Hematological_changes_among_Chinese_workers_with_a_broad_range_of_benzene_exposures"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="48400215" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/48400215/Risk_Analysis_Characterization_of_Benzene_and_Demographic_Factors_toward_Immunoglobulin_A">Risk Analysis Characterization of Benzene and Demographic Factors toward Immunoglobulin A</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5427360" href="https://upm.academia.edu/JulianaJalaludin">Juliana Jalaludin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Open Access Macedonian Journal of Medical Sciences</p><p class="ds-related-work--abstract ds2-5-body-sm">BACKGROUND: Research on risk assessment at industrial sites has experienced growth during the end of this year. But in Indonesia, there is still limited research on risk assessment, especially regarding the importance of measuring non-carcinogenic risk assessment in the workplace. Benzene exposure is believed to reduce levels of immunoglobulin A (IgA) in workers. AIM: The purpose of this study was to analyse the relationship between risk quotient (RQ) of non-carcinogenic risk assessment of benzene and demographic factors on IgA levels. MATERIAL AND METHODS: The subjects of the study were shoe craftsmen who were at risk of benzene exposure. The study design was cross-sectional with a total population of 20 workers. Measurement of IgA levels by Immunoturbidimetric Assay with a normal standard of 2-3 mg/ml. Calculation of non-carcinogenic (RQ) risk characteristics with a comparison between risk agent non-carcinogenic intake with RfD or RfC benzene. RESULTS: The majority of the study su...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Risk Analysis Characterization of Benzene and Demographic Factors toward Immunoglobulin A","attachmentId":67032625,"attachmentType":"pdf","work_url":"https://www.academia.edu/48400215/Risk_Analysis_Characterization_of_Benzene_and_Demographic_Factors_toward_Immunoglobulin_A","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/48400215/Risk_Analysis_Characterization_of_Benzene_and_Demographic_Factors_toward_Immunoglobulin_A"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="65849644" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/65849644/Lymphohaematopoeitic_cancer_mortality_among_workers_with_benzene_exposure">Lymphohaematopoeitic cancer mortality among workers with benzene exposure</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="194344425" href="https://independent.academia.edu/JimCollins37">Jim Collins</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Occupational and Environmental Medicine - OCCUP ENVIRON MEDICINE, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lymphohaematopoeitic cancer mortality among workers with benzene exposure","attachmentId":77268279,"attachmentType":"pdf","work_url":"https://www.academia.edu/65849644/Lymphohaematopoeitic_cancer_mortality_among_workers_with_benzene_exposure","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/65849644/Lymphohaematopoeitic_cancer_mortality_among_workers_with_benzene_exposure"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="23303336" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23303336/Hematotoxocity_among_Chinese_workers_heavily_exposed_to_benzene">Hematotoxocity among Chinese workers heavily exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45199469" href="https://independent.academia.edu/WeiLu36">Wei Lu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Industrial Medicine, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hematotoxocity among Chinese workers heavily exposed to benzene","attachmentId":43765602,"attachmentType":"pdf","work_url":"https://www.academia.edu/23303336/Hematotoxocity_among_Chinese_workers_heavily_exposed_to_benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/23303336/Hematotoxocity_among_Chinese_workers_heavily_exposed_to_benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="40613406" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/40613406/Hematological_changes_among_Sudanese_petroleum_workers_with_a_broad_range_of_benzene_exposure">Hematological changes among Sudanese petroleum workers with a broad range of benzene exposure</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="130544839" href="https://gulfmedical.academia.edu/AsaadMohammedAhmedAbdAllahBabker">Asaad Mohammed Ahmed Babker ,Ph.D.,H(ASCPi),SH(ASCPi)</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Scholars Journal of Applied Medical Sciences (SJAMS) , 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">To evaluate the hematological changes among workers with continuous exposure to benzene. This is a population-based-cross-sectional study was carried out to investigate the potential risk of exposure to benzene in Elobid city, Sudan, among Petrol Station workers. Short questionnaire was administered on the randomly chosen subjects to elicit demographic features of workers were recorded information on their exposure. And forty blood samples were collected and performed complete blood cell (CBC) and reticulocytes count for each participant. The data was entered and analyzed by SPSS prograrmme (version 16) and compared with international studies. In Result show that CBC parameters as follows : RBCs (Mean = 3.4±.6) (.00), Hb (Mean = 13.7±.5) (P value =.0.748), HCT(Mean = 41.9)(P value =.00), MCV(Mean = 77.9)(P value =.00), MCH(Mean =25.7)(P value =.00),MCHC(Mean = 32.7) P value =.00), RWDSD (Mean = 0.325) (.00), platelets count (Mean = 276.6),(P value=.045), TWBCs(Mean = 7.3±.6)(P value = .097), Retics count (Mean = 0.32) (.00). In conclusions, those exposed to benzene may develop bone marrow depression, as evidenced by drop in Reticulocytes, Hct and red cell indices in all workers WBC and platelets count were not sensitive indicators of benzene-induced hematotoxicity.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hematological changes among Sudanese petroleum workers with a broad range of benzene exposure","attachmentId":60892415,"attachmentType":"pdf","work_url":"https://www.academia.edu/40613406/Hematological_changes_among_Sudanese_petroleum_workers_with_a_broad_range_of_benzene_exposure","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/40613406/Hematological_changes_among_Sudanese_petroleum_workers_with_a_broad_range_of_benzene_exposure"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="12475685" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12475685/Early_hematological_and_immunological_alterations_in_gasoline_station_attendants_exposed_to_benzene">Early hematological and immunological alterations in gasoline station attendants exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31315301" href="https://fiocruz.academia.edu/FFreitas">Fernando Freitas</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Research, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Elucidation of effective biomarkers may provide tools for the early detection of biological alterations caused by benzene exposure and may contribute to the reduction of occupational diseases. This study aimed to assess early alterations on hematological and immunological systems of workers exposed to benzene. Methods: Sixty gasoline station attendants (GSA group) and 28 control subjects were evaluated. Environmental and biological monitoring of benzene exposure was performed in blood and urine. The potential effect biomarkers evaluated were δ-aminolevulinate dehydratase (ALA-D) activity, CD80 and CD86 expression in lymphocytes and monocytes, and serum interleukin-8 (IL-8). The influence of confounding factors and toluene co-exposure were considered. Results: Although exposures were below ACGIH (American Conference of Governmental Industrial Hygienists) limits, reduced ALA-D activity, decreased CD80 and CD86 expression in monocytes and increased IL-8 levels were found in the GSA group compared to the control subjects. Furthermore, according to multiple linear regression analysis, benzene exposure was associated to a decrease in CD80 and CD86 expression in monocytes. Conclusions: These findings suggest, for the first time, a potential effect of benzene exposure on ALA-D activity, CD80 and CD86 expression, IL-8 levels, which could be suggested as potential markers for the early detection of benzene-induced alterations.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Early hematological and immunological alterations in gasoline station attendants exposed to benzene","attachmentId":46155826,"attachmentType":"pdf","work_url":"https://www.academia.edu/12475685/Early_hematological_and_immunological_alterations_in_gasoline_station_attendants_exposed_to_benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12475685/Early_hematological_and_immunological_alterations_in_gasoline_station_attendants_exposed_to_benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="106199832" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/106199832/Retrospective_estimation_of_exposure_to_benzene_in_a_leukaemia_case_control_study_of_petroleum_marketing_and_distribution_workers_in_the_United_Kingdom">Retrospective estimation of exposure to benzene in a leukaemia case-control study of petroleum marketing and distribution workers in the United Kingdom</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32689791" href="https://independent.academia.edu/LesleyRushton">Lesley Rushton</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Occupational and Environmental Medicine, 1997</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective-To provide quantitative estimates of exposure to benzene for cases and controls in an epidemiology study to investigate the risk of leukaemia in petroleum distribution workers. Methods-Work histories were obtained for cases and controls together with detailed information on the distribution sites. For each job in the work history, an estimate of exposure (parts per million (ppm)) was obtained by multiplying a measure derived from exposure data by modifying factors to reflect the differences between the conditions that existed at the time of measurement and those at the time of interest. The modifying factors used related to job activity, the number of road tankers loaded, the benzene content of the gasoline, the mixture of products handled, temperature, and loading technology. Cumulative exposures for each case and control were obtained by multiplying the exposure estimates for each job by the duration of time in the respective jobs, and summing these over all jobs in the work history. Peak exposure and exposure through dermal contact were quantitatively classified for each job. Results-Measured exposures were obtained for 30 job categories, and ranged from 0-003 to 8-20 ppm. 40% of work histories were assigned background exposures, with a further 34% assigned the exposure estimate for a driver carrying out top submerged loading of motor fuel into road tankers. Cumulative exposures ranged from < 1 to > 200 ppm-years, although 81% were < 5 ppm-years. Comparison of the exposure estimates for selected jobs with data from sources not used in the study showed similar results. Conclusion-The estimates of exposure to benzene in this study provide a sound basis for the epidemiological analyses.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Retrospective estimation of exposure to benzene in a leukaemia case-control study of petroleum marketing and distribution workers in the United Kingdom","attachmentId":105458493,"attachmentType":"pdf","work_url":"https://www.academia.edu/106199832/Retrospective_estimation_of_exposure_to_benzene_in_a_leukaemia_case_control_study_of_petroleum_marketing_and_distribution_workers_in_the_United_Kingdom","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/106199832/Retrospective_estimation_of_exposure_to_benzene_in_a_leukaemia_case_control_study_of_petroleum_marketing_and_distribution_workers_in_the_United_Kingdom"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":71742492,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":71742492,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_71742492" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="18788311" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18788311/Lymphohaematopoietic_cancer_risk_among_chemical_workers_exposed_to_benzene">Lymphohaematopoietic cancer risk among chemical workers exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38868743" href="https://independent.academia.edu/LBloemen">Louis Bloemen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Occupational and Environmental Medicine, 2004</p><div 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="104074083" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/104074083/Environmental_exposure_to_benzene_evaluation_of_urinary_S_PMA_and_polymorphism_CYP2E1_1293G_C_and_NQO1_609C_T_in_Campos_El%C3%ADseos_residents_Duque_de_Caxias_Rio_de_Janeiro_State_Brazil">Environmental exposure to benzene: evaluation of urinary S-PMA and polymorphism (CYP2E1-1293G>C and NQO1 609C>T) in Campos Elíseos residents, Duque de Caxias, Rio de Janeiro State, Brazil</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="275388300" href="https://independent.academia.edu/YasminAlmeida99">Yasmin Almeida</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cadernos de Saúde Pública, 2019</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Environmental exposure to benzene: evaluation of urinary S-PMA and polymorphism (CYP2E1-1293G\u003eC and NQO1 609C\u003eT) in Campos Elíseos residents, Duque de Caxias, Rio de Janeiro State, Brazil","attachmentId":103898682,"attachmentType":"pdf","work_url":"https://www.academia.edu/104074083/Environmental_exposure_to_benzene_evaluation_of_urinary_S_PMA_and_polymorphism_CYP2E1_1293G_C_and_NQO1_609C_T_in_Campos_El%C3%ADseos_residents_Duque_de_Caxias_Rio_de_Janeiro_State_Brazil","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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href="https://independent.academia.edu/JimCollins37">Jim Collins</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chemico-Biological Interactions, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Low level occupational benzene exposure and hematological parameters","attachmentId":77268277,"attachmentType":"pdf","work_url":"https://www.academia.edu/65849619/Low_level_occupational_benzene_exposure_and_hematological_parameters","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/65849619/Low_level_occupational_benzene_exposure_and_hematological_parameters"><span 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