MacKenzie Lab - Homepage | UCSF MacKenzie Lab

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74.88 1 74.8802 1 74.8802" stroke="#CACED2" stroke-miterlimit="10"/> <path d="M1441 40.6085C1413.31 41.8672 1347.95 52.4947 1282.34 37.8121C1224.37 24.8424 1157.5 -8 1074.02 15.9147C990.54 39.8295 854.696 41.4105 790.852 36.5055C731.859 31.9703 699.904 31.62 640.079 29.427C538.688 25.7093 499.769 35.9695 395.448 39.8299C367.758 41.0886 325.915 34.1723 266.187 37.8121C206.459 41.4455 176.113 28.5776 114.057 30.5389C52 32.5003 35.5 37.8121 1 40.6103" stroke="#CACED2" stroke-miterlimit="10"/> <path d="M1441 74.8783C1323.58 74.8783 1257.6 69.6813 1172.61 61.0586C1104.74 54.1747 943.973 25.069 875.684 22.8695C685.557 16.7317 673.121 76.085 424.847 74.8783C213.911 68.1778 184.5 36.5007 116 15.5004C47.5 -5.5 1 3.12031 1 3.12031" stroke="#CACED2" stroke-miterlimit="10"/> </svg> </div> </div> <div class="content-carousel-card-content"> <div class="heading"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">MacKenzie Lab</div> </div> <div class="body"> <div class="clearfix text-formatted field field--name-field-body field--type-text field--label-hidden field__item">UCSF Department of Surgery</div> </div> </div> </div> </div> </div> </div> </div> <div class="field__item column-tippi-pic"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-column-wider-right paragraph paragraph--type--kan-columns paragraph--view-mode--default no-decor"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <article class="media media--type-image media--view-mode-rounded-overlay" aria-label="Image about Tippi MacKenzie 354x210"> <div class="corner-detail mobile"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="50px" height="50px" viewBox="0 0 50 50" style="enable-background:new 0 0 50 50;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,50 2.5,2.5 50,2.5 " /> </svg> </div> <div class="corner-detail desktop"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="100px" height="100px" viewBox="0 0 100 100" style="enable-background:new 0 0 100 100;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,100 2.5,2.5 100,2.5 " /> </svg> </div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/rounded_overlay/public/2024-08/dr-tippi-mackenzie-md-354x210_0.webp?itok=Fw3EETYD" width="354" height="210" alt="Tippi MacKenzie 354x210" class="image-style-rounded-overlay"> </div> </article> <div><h3 class="column-tippi-pic">Tippi MacKenzie, MD</h3><p style="font-size:1rem;">Professor of Surgery<br>Benioff UCSF Professor of Children’s Health<br>Director, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF<br>Co-Director, Center for Maternal-Fetal Precision Medicine<br>John G. Bowes Distinguished Professor of Stem Cell and Tissue Biology</p><p><a class="btn-secondary-outline-editor" href="/node/6596" data-entity-type="node" data-entity-uuid="9e1e28ee-0165-455f-9089-9aa8c123d24f" data-entity-substitution="canonical">Read Bio</a></p></div> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <h1>MacKenzie Lab</h1><h3>Mission:</h3><p class="less-height">Understanding the fundamental mechanisms of maternal-fetal biology in order to develop innovative fetal therapies for genetic diseases and pregnancy complications.</p><p class="less-height">To create a collaborative interdisciplinary research environment to train the next generation of scientists/physicians.</p><div class="lab_content_textarea_top"><h3 style="padding-top:15px;">Our Vision:</h3><p class="less-height">To translate discoveries in biology and technology into prenatal therapies that will transform medical care for expectant families.</p><h3 style="padding-top:15px;">Our Values:</h3><p class="less-height">The MacKenzie Lab is a diverse group of scientists from various backgrounds and from all over the world. As such, we approach each other with cultural humility, and we believe...</p><p class="less-height" style="padding-top:15px;"><a class="btn-outline-editor btn-secondary-outline-editor" href="/macKenzie-lab-about-us" data-entity-type="node" data-entity-uuid="28122d3e-dcea-45fc-ae40-2a53130c66d5" data-entity-substitution="canonical">Read More</a></p></div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns remove-top-padding columns--layout-column-wider-left paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">Our Research</div> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="view view-research view-id-research view-display-id-block_3 js-view-dom-id-c8575dc703d521d39f4f0516bf3bb4e69883fd7736915f2ccbf07d087a8fa5f1"> <div class="view-header"> <style>.associated-publications {margin-top:15px;} .associated-conditions-procedures {margin-top:15px;} .associated-physicians {margin-top:15px;} .item-research-body a { display: inline-block !important; font-size: 1rem !important; } .views-label.views-label-field-related-links a { text-decoration: none; color: #0f388a; cursor: auto; pointer-events: none; } .related-bio-row.views-row img { width: 55%; padding: 12px; text-align:center; } .research-rightbar-bio-img { background: linear-gradient(to bottom, #052049 0, rgba(22, 160, 172, 0.5) 50%, rgba(22, 160, 172, 0) 100%) !important; margin-bottom: 2rem; text-align: center; font-size: 1.3rem; } .field-content.rightbar-research-bio-image { font-size: 1.2rem; padding: 0 15px; } .associated-bios-block { margin-bottom:1rem;} .research-rightbar-assoc-bios {margin-bottom:2rem !important;} .field-content.research-rightbar-bios { font-weight: bold; padding: 10px; } .related-bio-row.views-row { border: 1px solid #7e92ae; border-bottom-right-radius: 40px; line-height: 1.25; margin-bottom: 1.25rem; } .research-rightbar-bio-text {font-size:1.25rem; margin: 1.25rem;} .research-rightbar-bios-title {font-size: 1.5rem; font-weight: bold; margin: 1.25rem;} .rightbar-elements { border-bottom-right-radius: 40px; 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These ...</div></div></div></div> <div class="research-row views-row"><div class="views-field views-field-title"><span class="field-content"><div class='item-research-title'><a href="/research/gene-therapy-vectors" hreflang="en">Gene Therapy Vectors</a></div></span></div><div class="views-field views-field-body"><div class="field-content"><div class='item-research-body'> Successful, safe gene therapy technologies often need equally safe and efficacious delivery vector to reach their intended target ...</div></div></div></div> <div class="research-row views-row"><div class="views-field views-field-title"><span class="field-content"><div class='item-research-title'><a href="/research/sacrococcygeal-teratomas" hreflang="en">Sacrococcygeal Teratomas</a></div></span></div><div class="views-field views-field-body"><div class="field-content"><div class='item-research-body'> Sacrococcygeal Teratomas (SCTs), which grow on the tailbone, are the most common tumor in fetuses and neonates. Although ...</div></div></div></div> </div> <div class="more-link"><a href="/macKenzie-lab-research">View All Research</a></div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item support-section"> <div > <div class="columns columns--layout-column-wider-right paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">Support our Lab</div> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <div class="support-section-text"><p>A gift to the MacKenzie Lab will help us to develop better ways to treat genetic diseases before birth.</p><p><a class="btn-secondary-outline-editor" 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srcset="/sites/default/files/styles/news_featured/public/2024-07/STAT_TippiMacKenzie_edit_0009-1600x900.webp?h=8abcec71&itok=LYcZcg0- 1308w" sizes="(min-width: 1290px) 81.75rem, (min-width: 768px) 100vw, (min-width: 560px) 100vw" width="1308" height="935" src="/sites/default/files/styles/news_featured/public/2024-07/STAT_TippiMacKenzie_edit_0009-1600x900.webp?h=8abcec71&itok=LYcZcg0-" alt="STAT News Tippi MacKenzie" /> </div> </article> </div> </div> <div class="featured-news-text-wrapper"> <p class="content-title"> <div class="ext__link field field--name-title field--type-string field--label-hidden field__item" target="_blank"><a href="https://www.statnews.com/2024/02/21/fetal-surgery-tippi-mackenzie-in-utero-gene-therapy/" class="ext__link field field--name-title field--type-string field--label-hidden field__item" target="_blank">Meet the fetal surgeon forging CRISPR’s next frontier: curing diseases in the womb</a></div> </p> <svg class="yellow-arrow" width="6" height="8" viewBox="0 0 6 8" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6 4L-3.26266e-07 7.4641L-2.34249e-08 0.535898L6 4Z" fill="#FEB80A"/> </svg> <a href="https://www.statnews.com/2024/02/21/fetal-surgery-tippi-mackenzie-in-utero-gene-therapy/" class="featured-story-link" rel="bookmark">Read full story</a> </div> </div> </article> </div> </div> </div> </div> </div> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="news-with-readmore view view-news-events view-id-news_events view-display-id-block_3 js-view-dom-id-61733d10581938b068815036199c7059117cb7c32844cfafa2fde3053911bb54"> <div class="view-header"> <style> .news-with-readmore .more-link { margin-top: 18px; border: 2px solid #ccc; transition: all 0.6s ease 0s; display: inline-block; border-radius: 6.375rem; padding: 5px 10px; border-color: #052049; font-family: "Helvetica Neue Medium", "HelveticaNeue", "Helvetica", "Arial", sans-serif; line-height: 1.25; letter-spacing: 0; transition: all 0.6s ease 0s; display: inline-block; border-radius: 6.375rem; color: #fff; border: 0.125rem solid transparent; border-top-color: transparent; border-right-color: transparent; border-bottom-color: transparent; border-left-color: transparent; text-align: center; cursor: pointer; -webkit-user-select: none; -moz-user-select: none; user-select: none; text-decoration: none; -webkit-appearance: none; -moz-appearance: none; appearance: none; position: relative; font-size: 1rem; padding: 0.625rem 1.25rem; background-color: transparent; color: #14828c; border-color: #14828c; } .news-with-readmore .more-link:hover { color: #052049; border-color: #052049; } .news-with-readmore .more-link a { text-decoration:none;} .news-with-readmore .more-link a::before { content: ""; width: 100%; height: 100%; outline: 0.25rem solid transparent; position: absolute; top: 0; left: 0; border-radius: 30px; } .news-with-readmore .more-link a:hover::before { outline-color: #052049; } .row-with-icon .news-icon { width: 24px !important; display: inline-block; } .row-with-icon.views-row a { display: inline !important; padding-left: 7px; vertical-align: 4px; } </style> </div> <div class="view-content"> <div class="row-with-icon views-row"><img src='/sites/default/files/2024-10/news-icon-2.png' class='news-icon' /><a href="/news/meet-fetal-surgeon-forging-crisprs-next-frontier-curing-diseases-womb" hreflang="en">Meet the fetal surgeon forging CRISPR’s next frontier: curing diseases in the womb</a> </div> <div class="row-with-icon views-row"><img src='/sites/default/files/2024-10/news-icon-2.png' class='news-icon' /><a href="/news/fetal-therapy-offers-hope-patients-rare-genetic-disorders" hreflang="en">Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders</a> </div> <div class="row-with-icon views-row"><img src='/sites/default/files/2024-10/news-icon-2.png' class='news-icon' /><a href="/news/3-ucsf-faculty-elected-national-academy-medicine-2022" hreflang="en">3 UCSF Faculty Elected to the National Academy of Medicine for 2022</a> </div> <div class="row-with-icon views-row"><img src='/sites/default/files/2024-10/news-icon-2.png' class='news-icon' /><a href="/news/baby-born-worlds-first-utero-stem-cell-transplant-trial" hreflang="en">Baby Born in World’s First In Utero Stem Cell Transplant Trial</a> </div> </div> <div class="more-link"><a href="/news">View All News</a></div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-equal paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <h2 style="padding-top:15px;">Videos</h2> <article class="media media--type-kan-remote-video media--view-mode-inline-image" aria-label="Image about "> <div class="field field--name-kan-field-media-oembed-video field--type-string field--label-hidden field__item iframe-container"><iframe src="https://mackenzielab.ucsf.edu/media/oembed?url=https%3A//www.youtube.com/watch%3Fv%3Df5t3aMBdNng&max_width=1280&max_height=720&hash=G9_uYnurjG69yqxjipl2ccTcw5w6iAwD2j8bMe9u3SM" width="1280" height="720" class="media-oembed-content" loading="eager" title="Curing Genetic Diseases Before Birth"></iframe> </div> </article> <ul><li><a class="fancybox videolink" href="https://www.youtube.com/watch?v=d2XGFYhfZQs" title="Treating Rare Genetic Diseases — In Utero">Treating Rare Genetic Diseases — In Utero</a></li><li><a class="fancybox videolink" href="https://www.youtube.com/watch?v=-fKJFOYZbf4">UCSF Prenatal Enzyme Replacement for Lysosomal Storage Diseases—PEARL Trial</a></li><li><a class="fancybox videolink" href="https://www.youtube.com/watch?v=_Fb0ZZZ0-K4">Prenatal Enzyme Replacement for Lysosomal Storage Diseases (PEARL) Phase 1 Clinical Trial Presentation</a></li><li><a class="fancybox videolink" href="https://vimeo.com/295220171">ATM — Part 1: Tippi and Elianna’s Story: Stopping a Fatal Blood Disease Before Birth</a></li><li><a class="fancybox videolink" href="https://vimeo.com/361864868">ATM — Part 2: Tippi, Elliott and Elianna’s Story: Little Girl Thrives After Fetal Stem Cell Transplant</a></li><li><a class="fancybox videolink" href="https://www.youtube.com/watch?v=a5Y_cXVmtxI">MacKenzie Mentor Award Nomination</a></li></ul> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__header"> <div class="filtered-list__title"> <h2>Featured Publications</h2> </div> </div> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="node--content node__content view view-publications-for-lab view-id-publications_for_lab view-display-id-block_2 js-view-dom-id-ec6bbd712bf4bb9bcd709670bdd838c14cf4e2b7657ea2df7d62ff14bd2607a4"> <div class="view-header"> <style> .node--content-pubs.node__content-pubs { margin: auto !important; width: 70% !important; } .node--content-pubs.node__content-pubs .item-list ol li { padding-bottom:.8rem; } .smal-size-font {font-size:11px;} .author-color {color:#0f388a;} </style><style> .item-list.pubs-outerlist { max-height: 560px; overflow: scroll; overflow-x: hidden; padding-right: 10px; overflow-y: auto; } .item-list.pubs-outerlist ol { margin-top: 0; } .view-publications-for-lab .more-link { 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.more-link a { text-decoration:none;} .view-publications-for-lab .more-link a::before { content: ""; width: 100%; height: 100%; outline: 0.25rem solid transparent; position: absolute; top: 0; left: 0; border-radius: 30px; } .view-publications-for-lab .more-link a:hover::before { outline-color: #052049; } </style> </div> <div class="view-content"> <div class="item-list pubs-outerlist"> <ol> <li><span class="views-field views-field-title"><span class="field-content"><b>In utero hematopoietic stem cell transplantation for Fanconi anemia.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/38991119">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>The Conundrum of Mechanics Versus Genetics in Congenital Hydrocephalus and Its Implications for Fetal Therapy Approaches: A Scoping Review.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/39218781">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/38766216">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/38827250">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/38327047">PubMed</a> </span></span></li> </ol> </div> </div> <div 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