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data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">11</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">11</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/PaolaPedata/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://uzh.academia.edu/MikeSSch%C3%A4fer"><img class="profile-avatar u-positionAbsolute" alt="Mike S Schäfer" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/315585/77988/4400165/s200_mike_s..sch_fer.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://uzh.academia.edu/MikeSSch%C3%A4fer">Mike S Schäfer</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Zurich, Switzerland</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://uff.academia.edu/VaniaEstrela"><img class="profile-avatar u-positionAbsolute" alt="Vania V Estrela" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/1569445/584405/780232/s200_vania_v..estrela.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://uff.academia.edu/VaniaEstrela">Vania V Estrela</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">UFF - Universidade Federal Fluminense</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://jaen.academia.edu/AntonioC%C3%A1mara"><img class="profile-avatar u-positionAbsolute" alt="Antonio Cámara" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/36657616/77445889/65982970/s200_antonio.c_mara.jpeg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://jaen.academia.edu/AntonioC%C3%A1mara">Antonio Cámara</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Universidad de Jaén</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://u-paris10.academia.edu/G%C3%A9rardSalem"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://u-paris10.academia.edu/G%C3%A9rardSalem">Gérard Salem</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Université Paris Nanterre</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://utah.academia.edu/MeganFix"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://utah.academia.edu/MeganFix">Megan Fix</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Utah</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://en-uoa-gr.academia.edu/CMarkopoulos"><img class="profile-avatar u-positionAbsolute" alt="C. Markopoulos" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/37735445/18220356/18198348/s200_c..markopoulos.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://en-uoa-gr.academia.edu/CMarkopoulos">C. Markopoulos</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">National and Kapodistrian University of Athens</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://unimore.academia.edu/PaoloMagistri"><img class="profile-avatar u-positionAbsolute" alt="Paolo Magistri" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/38401449/18501828/18464714/s200_paolo.magistri.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://unimore.academia.edu/PaoloMagistri">Paolo Magistri</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Università degli studi di Modena e Reggio Emilia</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://nus.academia.edu/DavideLomanto"><img class="profile-avatar u-positionAbsolute" alt="Davide Lomanto" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/40541467/11056670/12338373/s200_davide.lomanto.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://nus.academia.edu/DavideLomanto">Davide Lomanto</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">National University of Singapore</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://usc.academia.edu/MariaStapfer"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://usc.academia.edu/MariaStapfer">Maria Stapfer</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Southern California</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://mansoura.academia.edu/AhmedSetit"><img class="profile-avatar u-positionAbsolute" alt="Ahmed Setit" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/64609070/20167581/19906684/s200_ahmed.setit.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://mansoura.academia.edu/AhmedSetit">Ahmed Setit</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Mansoura University</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="37126197" href="https://www.academia.edu/Documents/in/Multivariate_Analysis"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/PaolaPedata","location":"/PaolaPedata","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/PaolaPedata","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Multivariate Analysis"]}" data-trace="false" data-dom-id="Pill-react-component-0008bdde-e498-42dc-8415-aa6d70626d35"></div> <div id="Pill-react-component-0008bdde-e498-42dc-8415-aa6d70626d35"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Paola Pedata</h3></div><div class="js-work-strip profile--work_container" data-work-id="17402712"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402712/Peritoneal_mesothelioma_description_of_a_case_and_review_of_literature"><img alt="Research paper thumbnail of Peritoneal mesothelioma: description of a case and review of literature" class="work-thumbnail" src="https://attachments.academia-assets.com/39487991/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402712/Peritoneal_mesothelioma_description_of_a_case_and_review_of_literature">Peritoneal mesothelioma: description of a case and review of literature</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElpidioGarzillo">Elpidio Garzillo</a></span></div><div class="wp-workCard_item"><span>International journal of immunopathology and pharmacology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is universally recognized by the scientific community that asbestos, widely used in the past i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is universally recognized by the scientific community that asbestos, widely used in the past in many industrial sectors, is responsible for the onset of certain diseases of pleural and peritoneal serous membranes; in particular, Peritoneal Mesothelioma (PM) is an exceptional case, extremely rare malignancy of the abdominal cavity. In this work we describe a 62 years-old man, formerly exposed to asbestos, complains of dyspepsia associated with pain, abdominal swelling and mild difficulty during inspiration. After intraoperative biopsy of three masses found in abdomen, malignant peritoneal mesothelioma was diagnosed. The patient subsequently was subjected to cycles of chemotherapy and multiple palliative paracentesis, the patient died after about 12 months from diagnosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bacd8c2db09dd677f297cd6b56a96493" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487991,"asset_id":17402712,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487991/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402712"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402712"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402712; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402712]").text(description); $(".js-view-count[data-work-id=17402712]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402712; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402712']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309275"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17309275/Exposure_to_heavy_metals_and_other_occupational_environmental_risk_agents_related_to_amyotrophic_lateral_sclerosis_a_review_of_literature"><img alt="Research paper thumbnail of Exposure to heavy metals and other occupational/environmental risk agents related to amyotrophic lateral sclerosis: a review of literature" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17309275/Exposure_to_heavy_metals_and_other_occupational_environmental_risk_agents_related_to_amyotrophic_lateral_sclerosis_a_review_of_literature">Exposure to heavy metals and other occupational/environmental risk agents related to amyotrophic lateral sclerosis: a review of literature</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NMiraglia">N. Miraglia</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>Giornale italiano di medicina del lavoro ed ergonomia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In recent years, scientific literature has been giving more and more importance to the study of t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In recent years, scientific literature has been giving more and more importance to the study of the occupational/environmental exposure to risk agents related to the onset of Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex. Aim of this work is to verify the state of art about the eventual role of occupational/environmental exposure to risk agents. Selected articles, on the basis of keywords, year of publication and topics, are related to occupational and environmental exposure to xenobiotics, and, in particular, to the exposure to heavy metals that could lead to neuronal damage mechanisms involved in ALS onset. The review shows that although the scientific production has increased the interest in the evaluation of extra-genetic causes of ALS onset, there are still few studies concerning the careful study of the work activities of the individual patien...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309275"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309275"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309275; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309275]").text(description); $(".js-view-count[data-work-id=17309275]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309275; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309275']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="17402711"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402711/Evaluation_by_environmental_monitoring_of_pesticide_absorption_in_farm_workers_of_18_Italian_tomato_cultivations"><img alt="Research paper thumbnail of Evaluation by environmental monitoring of pesticide absorption in farm workers of 18 Italian tomato cultivations" class="work-thumbnail" src="https://attachments.academia-assets.com/39487995/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402711/Evaluation_by_environmental_monitoring_of_pesticide_absorption_in_farm_workers_of_18_Italian_tomato_cultivations">Evaluation by environmental monitoring of pesticide absorption in farm workers of 18 Italian tomato cultivations</a></div><div class="wp-workCard_item"><span>International journal of immunopathology and pharmacology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tomato cultivation farms of Southern Italy were investigated in order to evaluate the general wor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tomato cultivation farms of Southern Italy were investigated in order to evaluate the general working conditions and the levels of exposure of farm workers to pesticides, during the mixing/loading and the application of pesticides on fields. Information on working modalities, personal protective equipment, etc. was collected using a questionnaire. Inhaling and cutaneous exposure levels were measured, and the estimated pesticide total absorbed dose was compared with Admissible Daily Intakes (ADIs). Field treatments were mainly carried out by using sprayers with open cab tractors, and, in 57.9 percent of cases, the pesticide mixture was manually prepared by mixing pesticides in a pail, often without using gloves (59.5 percent). The estimated pesticides absorbed doses varied in the range 0.56-2630.31 mg (mean value, 46.9 mg), and 20 percent of the measured absorbed doses exceeded ADIs. The findings obtained in the 18 examined farms show a worrying situation, suggesting the investigatio...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b946f4b95238113f2260dd5136de0bbb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487995,"asset_id":17402711,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487995/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402711"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402711"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402711; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402711]").text(description); $(".js-view-count[data-work-id=17402711]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402711; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402711']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b946f4b95238113f2260dd5136de0bbb" } } $('.js-work-strip[data-work-id=17402711]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402711,"title":"Evaluation by environmental monitoring of pesticide absorption in farm workers of 18 Italian tomato cultivations","internal_url":"https://www.academia.edu/17402711/Evaluation_by_environmental_monitoring_of_pesticide_absorption_in_farm_workers_of_18_Italian_tomato_cultivations","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487995,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487995/thumbnails/1.jpg","file_name":"Evaluation_by_environmental_monitoring_o20151028-10128-29xe9q.pdf","download_url":"https://www.academia.edu/attachments/39487995/download_file","bulk_download_file_name":"Evaluation_by_environmental_monitoring_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487995/Evaluation_by_environmental_monitoring_o20151028-10128-29xe9q-libre.pdf?1446032918=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_by_environmental_monitoring_o.pdf\u0026Expires=1740608699\u0026Signature=SKfoAp3QRZ49TkB5T5aJkrNfBsCfTbQBgIMJwhgcJoWRitFiDmg1m6SPL1iMwIRkdxsIm1~Z3HmW1vA1iiWuC27XmI81eFGF5fLyTdxpfdPbYz3bLC-8Pjlf7dRfWlwgn-80~jAJVh4-mjD8mvYoBuA6HmI84RpXkhTTqn7B6nYOuaXVRcAWbVeMM7wMeef3whdP~cLM6CTQHTbZ2toJy4LzyjLOei7uisVi6xQcgYDrUk42M0iPEQqnv9cyidQ3VyXpktjFk1NQpB~zh8G1tZXMKye6gxKXWnINkcdoLxc4VMP0ophRQE-xh8wOlY5p3fT9jvcbhJEshsGDcx2lyw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402710"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402710/A_case_study_of_benzene_urinary_biomarkers_quantification_the_comparison_between_pre_and_postshift_samples_improves_the_interpretation_of_individual_biological_monitoring_data"><img alt="Research paper thumbnail of A case study of benzene urinary biomarkers quantification: the comparison between pre- and postshift samples improves the interpretation of individual biological monitoring data" class="work-thumbnail" src="https://attachments.academia-assets.com/39487941/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402710/A_case_study_of_benzene_urinary_biomarkers_quantification_the_comparison_between_pre_and_postshift_samples_improves_the_interpretation_of_individual_biological_monitoring_data">A case study of benzene urinary biomarkers quantification: the comparison between pre- and postshift samples improves the interpretation of individual biological monitoring data</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: benzene is an ubiquitous pollutant of working and living environments. Hence occupa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: benzene is an ubiquitous pollutant of working and living environments. Hence occupational prevention strategies need to discriminate between different exposure sources. The aim of the study is to take into account confounding factors in the evaluation of occupational exposure to benzene by biological monitoring (BM) investigations in small working realities. Materials and Methods: the BM of 14 workers of a refueling station was performed. Urinary benzene (UB) and trans, trans-muconic acid (t,t-MA) were used as biological markers. UB and t,t-MA determinations were performed by head space-solid phase microextraction followed by gas chromatography/mass spectrometry and High Performance Liquid Chromatography/UltraViolet detection. Urine collection was performed after work-shift (first BM campaign) as suggested by ACGIH. Subsequently, the urine collection was repeated before and after the work-shift (second BM campaign). Results: during the first BM campaign, contrasting results were found. Some workers showed low UB concentrations with respect to t,t-MA ones and vice versa, and although most subjects presented UB and t,t-MA levels below Biological Equivalents values and ACGIH's BEI, various exceptions were found. Biomarkers concentration decrements were observed by comparing pre-and post-shift samples (second BM campaign). Discussion: according to the ACGIH, the high biomarkers levels found in post-shift urine would suggest occupational exposure to benzene. Nevertheless, results obtained by monitoring post-shift urine only, without knowing individual background levels do not facilitate data interpretation. Findings from the second BM campaign suggest that biological monitoring strategies aimed to evaluate the occupational exposure of individuals to ubiquitous hazardous chemicals, need the measurement of biomarkers concentration both before and after the work-shift.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="84b2e8ea83e1d861d1b3e5ff765ffe1f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487941,"asset_id":17402710,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487941/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402710"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402710"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402710; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402710]").text(description); $(".js-view-count[data-work-id=17402710]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402710; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402710']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "84b2e8ea83e1d861d1b3e5ff765ffe1f" } } $('.js-work-strip[data-work-id=17402710]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402710,"title":"A case study of benzene urinary biomarkers quantification: the comparison between pre- and postshift samples improves the interpretation of individual biological monitoring data","internal_url":"https://www.academia.edu/17402710/A_case_study_of_benzene_urinary_biomarkers_quantification_the_comparison_between_pre_and_postshift_samples_improves_the_interpretation_of_individual_biological_monitoring_data","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487941,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487941/thumbnails/1.jpg","file_name":"A_case_study_of_benzene_urinary_biomarke20151028-10128-of6u0d.pdf","download_url":"https://www.academia.edu/attachments/39487941/download_file","bulk_download_file_name":"A_case_study_of_benzene_urinary_biomarke.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487941/A_case_study_of_benzene_urinary_biomarke20151028-10128-of6u0d-libre.pdf?1446032655=\u0026response-content-disposition=attachment%3B+filename%3DA_case_study_of_benzene_urinary_biomarke.pdf\u0026Expires=1740608699\u0026Signature=GY7Tj9SkJ5gdKsYNrV7h9bL~rQN8m7OyvKNcj6PHAkCqmI3RL63TMcinnpzQgQ7ew~CtVlFpXj9xy9cEJ-KfK-01w9BVo~0qyFtg8snzah1hdQCVYEr29lsQOk5hNsYtSY-lcTgaiWV6Kf-jyPPC~gqeRYH7S1X0wDrPR08Pc-7wGQvCs0cfQL95G~o5DAsmGqBg0mStmjFoZT7gD8UrMOiSVHtQmr5QVcvR9dO-4VMGTYr6VkE9jGyb2kBF2SjNPnFDusq7Tl2Q23GpwZwL6YJ5oKxwxtqryK2zHwK~ecnRj4GttAQjR5uT0QzEa7m-URlQj7hO-niOmBj1E0oH8w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402709"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402709/Using_the_Mini_Mental_State_Examination_MMSE_for_preliminary_assessment_of_cognitive_impairment_in_subjects_exposed_to_air_pollution_with_particulate_matter"><img alt="Research paper thumbnail of Using the Mini-Mental State Examination (MMSE) for preliminary assessment of cognitive impairment in subjects exposed to air pollution with particulate matter" class="work-thumbnail" src="https://attachments.academia-assets.com/39487984/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402709/Using_the_Mini_Mental_State_Examination_MMSE_for_preliminary_assessment_of_cognitive_impairment_in_subjects_exposed_to_air_pollution_with_particulate_matter">Using the Mini-Mental State Examination (MMSE) for preliminary assessment of cognitive impairment in subjects exposed to air pollution with particulate matter</a></div><div class="wp-workCard_item"><span>Giornale italiano di medicina del lavoro ed ergonomia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Epidemiologic and clinical studies have linked elevated concentrations of particulate matter to a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Epidemiologic and clinical studies have linked elevated concentrations of particulate matter to adverse health effects. In particular, has been demonstrated an association between UFPs exposure and occurrence of acute respiratory infections, lung cancer, chronic chronic obstructive pulmonary diseases and cardiovascular diseases. Recently, the exposure to particulate air pollution has been linked to cognitive decline. In this work, we used the Mini-Mental State Examination (MMSE) in a preliminary assessment of cognitive function in individuals who have lived and carried out work in heavily urbanized areas, where ambient levels of particulate air pollution were frequently above the standard of the law. The results showed the presence of mild-moderate cognitive impairment in 39.4% of the subjects examined compared to the control group.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="83f412156529abf6cb37cea4db6ef598" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487984,"asset_id":17402709,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487984/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402709"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402709"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402709; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402709]").text(description); $(".js-view-count[data-work-id=17402709]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402709; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402709']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "83f412156529abf6cb37cea4db6ef598" } } $('.js-work-strip[data-work-id=17402709]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402709,"title":"Using the Mini-Mental State Examination (MMSE) for preliminary assessment of cognitive impairment in subjects exposed to air pollution with particulate matter","internal_url":"https://www.academia.edu/17402709/Using_the_Mini_Mental_State_Examination_MMSE_for_preliminary_assessment_of_cognitive_impairment_in_subjects_exposed_to_air_pollution_with_particulate_matter","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487984,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487984/thumbnails/1.jpg","file_name":"Using_the_Mini-Mental_State_Examination_20151028-29725-5bcym8.pdf","download_url":"https://www.academia.edu/attachments/39487984/download_file","bulk_download_file_name":"Using_the_Mini_Mental_State_Examination.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487984/Using_the_Mini-Mental_State_Examination_20151028-29725-5bcym8-libre.pdf?1446032920=\u0026response-content-disposition=attachment%3B+filename%3DUsing_the_Mini_Mental_State_Examination.pdf\u0026Expires=1740608699\u0026Signature=Kc5ZMBzRD1W6Hfe-T4ygmvCVI6Yd6TE~Z0goS4C2l1V8Ir7sECrFwiKNZKJSeq2zsu2mJMmc5b36saq9NI6hadGZS11NHM~8V4CzP4BfSbcIOjezETiswJinClGQh-g8iEQFvQuANjL~RMlar~mWiDqyFogq3tFvhmmFEv0xe5yrvn9zh2EFrKNmMN3LG5p9SGFLi1IenywdcRYXGTpydj1vf7VQDY7odBFNQmVYUxm3X3DH-M5j68u56-f4SAvlWdJ5uBMtCclBYY8~4SWmLMrFfp2fxSaHgZRvu~yRhNu3TLQl0K97RHTT2~gw8JN5yFlErgZDuqL-stXNOJzyLQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309270"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17309270/Working_Conditions_and_Mental_Health_Results_from_the_CARESUN_Study"><img alt="Research paper thumbnail of Working Conditions and Mental Health: Results from the CARESUN Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17309270/Working_Conditions_and_Mental_Health_Results_from_the_CARESUN_Study">Working Conditions and Mental Health: Results from the CARESUN Study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>Archives of Environmental & Occupational Health</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We conducted a work-related stress surveillance study in 2013 on 6558 public-sector employees in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We conducted a work-related stress surveillance study in 2013 on 6558 public-sector employees in Italy, examining how they perceived their jobs, via the Job Content Questionnaire, and their mental health status, via the General Health Questionnaire 12 (GHQ-12). Of the 2094 employees completing the questionnaires, 60% were male, 52% had a medium-level education, and 76% had a medium-level job. Three hundred and eighty-five employees (18%) had a GHQ-12 score &amp;amp;amp;gt;3 and were classified as GHQ-12 cases: these were more often female (54%), medium-to-highly educated (54%), and had more often reported health problems over the previous year (51%). Thus, GHQ-12 cases represented a significant percentage of our examined population, indicating that work-related stress surveillance programs are needed for the planning of psychosocial interventions aimed at the reintegration of individuals with mental health problems.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309270"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309270"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309270; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309270]").text(description); $(".js-view-count[data-work-id=17309270]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309270; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309270']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17309270]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17309270,"title":"Working Conditions and Mental Health: Results from the CARESUN Study","internal_url":"https://www.academia.edu/17309270/Working_Conditions_and_Mental_Health_Results_from_the_CARESUN_Study","owner_id":36993140,"coauthors_can_edit":true,"owner":{"id":36993140,"first_name":"Nicola","middle_initials":null,"last_name":"Sannolo","page_name":"NicolaSannolo","domain_name":"unina2","created_at":"2015-10-26T08:29:18.139-07:00","display_name":"Nicola Sannolo","url":"https://unina2.academia.edu/NicolaSannolo"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402708"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402708/Engineered_metal_based_nanoparticles_and_innate_immunity"><img alt="Research paper thumbnail of Engineered metal based nanoparticles and innate immunity" class="work-thumbnail" src="https://attachments.academia-assets.com/39487937/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402708/Engineered_metal_based_nanoparticles_and_innate_immunity">Engineered metal based nanoparticles and innate immunity</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unich-it.academia.edu/enricosabbioni">enrico sabbioni</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unich-it.academia.edu/RobertoPaganelli">Roberto Paganelli</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://en-unich.academia.edu/MarioDiGioacchino">Mario Di Gioacchino</a></span></div><div class="wp-workCard_item"><span>Clinical and Molecular Allergy</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Almost all people in developed countries are exposed to metal nanoparticles (MeNPs) that are used...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Almost all people in developed countries are exposed to metal nanoparticles (MeNPs) that are used in a large number of applications including medical (for diagnostic and therapeutic purposes). Once inside the body, absorbed by inhalation, contact, ingestion and injection, MeNPs can translocate to tissues and, as any foreign substance, are likely to encounter the innate immunity system that represent a non-specific first line of defense against potential threats to the host. In this review, we will discuss the possible effects of MeNPs on various components of the innate immunity (both specific cells and barriers). Most important is that there are no reports of immune diseases induced by MeNPs exposure: we are operating in a safe area. However, in vitro assays show that MeNPs have some effects on innate immunity, the main being toxicity (both cyto-and genotoxicity) and interference with the activity of various cells through modification of membrane receptors, gene expression and cytokine production. Such effects can have both negative and positive relevant impacts on humans. On the one hand, people exposed to high levels of MeNPs, as workers of industries producing or applying MeNPs, should be monitored for possible health effects. On the other hand, understanding the modality of the effects on immune responses is essential to develop medical applications for MeNPs. Indeed, those MeNPs that are able to stimulate immune cells could be used to develop of new vaccines, promote immunity against tumors and suppress autoimmunity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f151523305f29fd7a39cd4ef11724ce" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487937,"asset_id":17402708,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487937/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402708"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402708]").text(description); $(".js-view-count[data-work-id=17402708]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402708']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f151523305f29fd7a39cd4ef11724ce" } } $('.js-work-strip[data-work-id=17402708]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402708,"title":"Engineered metal based nanoparticles and innate immunity","internal_url":"https://www.academia.edu/17402708/Engineered_metal_based_nanoparticles_and_innate_immunity","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487937,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487937/thumbnails/1.jpg","file_name":"Engineered_metal_based_nanoparticles_and20151028-28426-1dnq89k.pdf","download_url":"https://www.academia.edu/attachments/39487937/download_file","bulk_download_file_name":"Engineered_metal_based_nanoparticles_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487937/Engineered_metal_based_nanoparticles_and20151028-28426-1dnq89k-libre.pdf?1446032656=\u0026response-content-disposition=attachment%3B+filename%3DEngineered_metal_based_nanoparticles_and.pdf\u0026Expires=1740131996\u0026Signature=Lj7qdKx~b~wUPz0lJzLU5F8j454cFPOW5GBS7etyIkS2plwB6CxKmQE9RtfR1EVT3gPATmnCsVo0A7LxEGhF8Qh2j~IaIrhZ0MFoZIPRCoYBrJ7aeG4Tf8nU3iROBspQ3s84jS95KgfiUKEo5EisFeqLWTVefpCtk9Bqbo-GTgWA-H8JPeuUZp2IZL0Ayh0iyChEgnXc-ahg0XJ10FFMVTAwReg4ScA26LEQaLwKK6CHr1iem3kKaHBa-2yNAykjv6s59ZsN2n3vusNNwxnJZbJUT0O63qcYx3FyW32rTsOLS32mE4rOfS90DckpprvHoq~8MISWkC2Qsrfr6v2NJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309268"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309268/_Human_health_effects_of_ultrafine_particles_"><img alt="Research paper thumbnail of [Human health effects of ultrafine particles]" class="work-thumbnail" src="https://attachments.academia-assets.com/39437946/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309268/_Human_health_effects_of_ultrafine_particles_">[Human health effects of ultrafine particles]</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>Giornale italiano di medicina del lavoro ed ergonomia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Epidemiologic and clinical studies have linked elevated concentrations of ambient ultrafine parti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Epidemiologic and clinical studies have linked elevated concentrations of ambient ultrafine particles (UFPs) to adverse health effects. In particular, has been demonstrated an association between UFPs exposure and occurrence of acute respiratory infections, lung cancer, chronic chronic obstructive pulmonary diseases and cardiovascular diseases. Although the biological mechanisms behind these associations are not fully understood, the results of in vitro toxicological research have shown that UFPs induces several types of adverse cellular effects, including cytotoxicity, mutagenicity, DNA oxidative damage and stimulation of proinflammatory cytokine production. In this reviewer are summarized the results of the recent epidemiological and toxicological studies on adverse health effects from exposure to UFPs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="57b621fa3768fb954e306109ace71896" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39437946,"asset_id":17309268,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39437946/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309268"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309268"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309268; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309268]").text(description); $(".js-view-count[data-work-id=17309268]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309268; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309268']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309267"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309267/Carbon_nanotubes_Properties_biomedical_applications_advantages_and_risks_in_patients_and_occupationally_exposed_workers"><img alt="Research paper thumbnail of Carbon nanotubes: Properties, biomedical applications, advantages and risks in patients and occupationally-exposed workers" class="work-thumbnail" src="https://attachments.academia-assets.com/39437944/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309267/Carbon_nanotubes_Properties_biomedical_applications_advantages_and_risks_in_patients_and_occupationally_exposed_workers">Carbon nanotubes: Properties, biomedical applications, advantages and risks in patients and occupationally-exposed workers</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>International journal of immunopathology and pharmacology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced in pharmacy and medicine for drug delivery system in therapeutics. CNTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomedical applications such as advanced imaging, tissue regeneration, and drug or gene delivery. Although there are many data on the advantages in terms of higher efficacy and less adverse effects, several recent findings have reported unexpected toxicities induced by CNTs. The dose, shape, surface chemistry, exposure route, and purity play important roles in these differential toxicities. Mapping these risks as well as understanding their molecular mechanisms is a crucial step in the development of any CNT-containing nanopharmaceuticals. This paper seeks to provide a comprehensive review of all articles published on cellular response to CNTs, underlining their therapeutic a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bba2b5e23433f4b315ff0b0cbe44c179" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39437944,"asset_id":17309267,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39437944/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309267"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309267"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309267; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309267]").text(description); $(".js-view-count[data-work-id=17309267]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309267; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309267']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309263"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309263/Blood_Lead_Manganese_and_Aluminum_Levels_in_a_Regional_Italian_Cohort_of_ALS_Patients"><img alt="Research paper thumbnail of Blood Lead, Manganese, and Aluminum Levels in a Regional Italian Cohort of ALS Patients" class="work-thumbnail" src="https://attachments.academia-assets.com/41904370/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309263/Blood_Lead_Manganese_and_Aluminum_Levels_in_a_Regional_Italian_Cohort_of_ALS_Patients">Blood Lead, Manganese, and Aluminum Levels in a Regional Italian Cohort of ALS Patients</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NMiraglia">N. Miraglia</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElpidioGarzillo">Elpidio Garzillo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LucaDaniele1">Luca Daniele</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MariaMonsurro">Maria Monsurro</a></span></div><div class="wp-workCard_item"><span>Journal of Occupational and Environmental Medicine</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae37bca3ce300dda2a1b0b0b384af2f7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41904370,"asset_id":17309263,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41904370/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309263"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309263"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309263; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402707"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402707/Carbon_TiO2_Nanostructures_Flame_Synthesis_and_Characterization"><img alt="Research paper thumbnail of Carbon-TiO2 Nanostructures: Flame Synthesis and Characterization" class="work-thumbnail" src="https://attachments.academia-assets.com/41890057/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402707/Carbon_TiO2_Nanostructures_Flame_Synthesis_and_Characterization">Carbon-TiO2 Nanostructures: Flame Synthesis and Characterization</a></div><div class="wp-workCard_item"><span>MRS Proceedings</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The synthesis of pure titania and carbon-titania nano-powders in a premixed atmospheric fuel-rich...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The synthesis of pure titania and carbon-titania nano-powders in a premixed atmospheric fuel-rich flame was studied. The variation of the flame C/O ratio allows to produce both pure titania and carbon-TiO 2 nanoparticles. Raman Spectroscopy, X-ray Diffraction, Atomic Force Microscopy, Electrical Low Pressure Impactor and Scanning Electron Microscopy were used to characterize the synthesized nano-powders, in terms of crystallinity, phase content, size and morphology. Produced nano-powders with a dimension of 25-40 nm are composed by both rutile and anatase phases, with rutile being the predominant one. Reactive Oxygen Species analysis performed on the synthesized nano-powders showed that the inclusion of carbon in the nanopowders results in a reduced adverse health effect, in terms of ROS production.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dd79b43791d68cf1343385b77f702216" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41890057,"asset_id":17402707,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41890057/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402707"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402707"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402707; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309256"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17309256/Doxorubicin_can_penetrate_nitrile_gloves_and_induces_apoptosis_in_keratinocytes_cell_lines"><img alt="Research paper thumbnail of Doxorubicin can penetrate nitrile gloves and induces apoptosis in keratinocytes cell lines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17309256/Doxorubicin_can_penetrate_nitrile_gloves_and_induces_apoptosis_in_keratinocytes_cell_lines">Doxorubicin can penetrate nitrile gloves and induces apoptosis in keratinocytes cell lines</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NMiraglia">N. Miraglia</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>Toxicology Letters</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Doxorubicin (DOXO) is an anthracycline antibiotic which is used in the treatment of human maligna...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Doxorubicin (DOXO) is an anthracycline antibiotic which is used in the treatment of human malignancies such as leukemia, lymphoma and a number of solid tumors, particularly breast cancer. Anthracyclines have been reported to contaminate chemotherapy workstation surfaces as well as other workplaces surfaces. The occupational exposure to these drugs could occur in hospitals, for nurses involved in anthracyclines preparation and administration, in chemical industries during the commercial formulate syntheses, and in analytical laboratories. Numerous studies investigated cutaneous effects related to DOXO administration, on the contrary few literature data are available about effects on the skin due to the direct contact with the drug. The present study investigated the DOXO permeability of three commercially available gloves&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; types used to protect skin in occupational contexts, as well as the effects of DOXO on human keratinocyte cell line (HaCaT). The results suggest that the DOXO permeability of gloves depends not only on glove material but also on DOXO solutions&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; pH, in fact nitrile gloves can be penetrated by acid solutions, while neither natural rubbers nor nitrile gloves are permeable to neutral solutions. Moreover, DOXO solutions, even at low concentration, cause apoptosis in epithelial cells, through activation of intrinsic pathway p53-independent.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309256"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309256"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309256; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309255]").text(description); $(".js-view-count[data-work-id=17309255]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309255; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309255']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402706"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402706/Interaction_between_combustion_generated_organic_nanoparticles_and_biological_systems_In_vitro_study_of_cell_toxicity_and_apoptosis_in_human_keratinocytes"><img alt="Research paper thumbnail of Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes" class="work-thumbnail" src="https://attachments.academia-assets.com/39487935/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402706/Interaction_between_combustion_generated_organic_nanoparticles_and_biological_systems_In_vitro_study_of_cell_toxicity_and_apoptosis_in_human_keratinocytes">Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/patriziaminutolo">patrizia minutolo</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a></span></div><div class="wp-workCard_item"><span>Nanotoxicology</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eaf2cb2cdb5597a656af51bf9c7495f1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487935,"asset_id":17402706,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487935/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402706"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402706"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402706; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402705"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402705/Epirubicin_permeation_of_personal_protective_equipment_can_induce_apoptosis_in_keratinocytes"><img alt="Research paper thumbnail of Epirubicin permeation of personal protective equipment can induce apoptosis in keratinocytes" class="work-thumbnail" src="https://attachments.academia-assets.com/39487981/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402705/Epirubicin_permeation_of_personal_protective_equipment_can_induce_apoptosis_in_keratinocytes">Epirubicin permeation of personal protective equipment can induce apoptosis in keratinocytes</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a></span></div><div class="wp-workCard_item"><span>Journal of Exposure Science and Environmental Epidemiology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study investigated the epirubicin (EPI) permeability of various commercially availabl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study investigated the epirubicin (EPI) permeability of various commercially available glove types, as well as toxicity mechanisms and effects on human keratinocyte cell line (HaCaT). Permeability experiments were carried out on various commercially available gloves, differing as regards material and thickness. Permeability was evaluated after different ''contact times'' and the influence of EPI solution's pH (acid and neutral) on permeability was also examined. Toxicity of EPI toward skin was tested by evaluating the effects of the drug on cell growth and apoptosis, by using an in vitro model based on cultured immortalized human keratinocytes. No permeation was detected in the case of EPI neutral solutions; in contrast, acid solutions were found to penetrate low thickness nitrile gloves. Obtained results also showed the induction of apoptosis in epithelial cells through the activation of intrinsic pathway p53-independent occurring even when cells are exposed at low drug concentration. EPI solution's pH influences the glove's permeability; once penetrated, EPI at concentrations lower than those able to penetrate the nitrile glove during the 8-h work-shift can cause apoptosis in epithelial cells. The findings reported here highly support the choice of either natural rubbers gloves or high thickness nitrile ones for preventing the occupational exposure to EPI Q2 .</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="73134e3ac917f7a00ab252cdb3bd6463" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487981,"asset_id":17402705,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487981/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402705"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402705"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402705; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309241"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309241/Functional_changes_in_human_peripheral_neutrophils_in_workers_with_different_exposure_to_noxious_agents"><img alt="Research paper thumbnail of Functional changes in human peripheral neutrophils in workers with different exposure to noxious agents" class="work-thumbnail" src="https://attachments.academia-assets.com/39437931/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309241/Functional_changes_in_human_peripheral_neutrophils_in_workers_with_different_exposure_to_noxious_agents">Functional changes in human peripheral neutrophils in workers with different exposure to noxious agents</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NMiraglia">N. Miraglia</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElpidioGarzillo">Elpidio Garzillo</a>, and <a class="" data-click-track="profile-work-strip-authors" rel="nofollow" href="https://independent.academia.edu/RosarioMiranda1">Rosario Miranda</a></span></div><div class="wp-workCard_item"><span>International Journal of Environmental Health Research</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3462362ad001f07d45ccde014385e7ce" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39437931,"asset_id":17309241,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39437931/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309241"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309241"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309241; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309282"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309282/Ultrafine_particles_and_effects_on_the_organism_Literature_review"><img alt="Research paper thumbnail of Ultrafine particles and effects on the organism: Literature review" class="work-thumbnail" src="https://attachments.academia-assets.com/39437950/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309282/Ultrafine_particles_and_effects_on_the_organism_Literature_review">Ultrafine particles and effects on the organism: Literature review</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElpidioGarzillo">Elpidio Garzillo</a></span></div><div class="wp-workCard_item"><span>Giornale italiano di medicina del lavoro ed ergonomia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Negli ultimi anni, l'interesse della comunità scientifica internazionale nel campo della ricerca ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Negli ultimi anni, l'interesse della comunità scientifica internazionale nel campo della ricerca si è incentrato sullo studio degli effetti del particolato ultrafine sulla salute umana. Le particelle ultrafini (PM 0.1 : diametro aerodinamico medio inferiore a 0.1 µm) sono complesse miscele di sostanze organiche ed inorganiche, dotate di intrinseca tossicità. Le loro piccole dimensioni le rendono degne di particolare attenzione in quanto sono in grado di penetrare fino alle vie aeree più profonde, sfuggendo ai normali meccanismi di difesa polmonare, ed entrare nel circolo sanguigno (1-6).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e60f6f0cd15c89ad7ff73623b3ba570e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39437950,"asset_id":17309282,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39437950/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309282"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309282"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309282; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309282]").text(description); $(".js-view-count[data-work-id=17309282]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309282; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309282']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3865159" id="papers"><div class="js-work-strip profile--work_container" data-work-id="17402712"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402712/Peritoneal_mesothelioma_description_of_a_case_and_review_of_literature"><img alt="Research paper thumbnail of Peritoneal mesothelioma: description of a case and review of literature" class="work-thumbnail" src="https://attachments.academia-assets.com/39487991/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402712/Peritoneal_mesothelioma_description_of_a_case_and_review_of_literature">Peritoneal mesothelioma: description of a case and review of literature</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElpidioGarzillo">Elpidio Garzillo</a></span></div><div class="wp-workCard_item"><span>International journal of immunopathology and pharmacology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is universally recognized by the scientific community that asbestos, widely used in the past i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is universally recognized by the scientific community that asbestos, widely used in the past in many industrial sectors, is responsible for the onset of certain diseases of pleural and peritoneal serous membranes; in particular, Peritoneal Mesothelioma (PM) is an exceptional case, extremely rare malignancy of the abdominal cavity. In this work we describe a 62 years-old man, formerly exposed to asbestos, complains of dyspepsia associated with pain, abdominal swelling and mild difficulty during inspiration. After intraoperative biopsy of three masses found in abdomen, malignant peritoneal mesothelioma was diagnosed. The patient subsequently was subjected to cycles of chemotherapy and multiple palliative paracentesis, the patient died after about 12 months from diagnosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bacd8c2db09dd677f297cd6b56a96493" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487991,"asset_id":17402712,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487991/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402712"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402712"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402712; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402712]").text(description); $(".js-view-count[data-work-id=17402712]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402712; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402712']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bacd8c2db09dd677f297cd6b56a96493" } } $('.js-work-strip[data-work-id=17402712]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402712,"title":"Peritoneal mesothelioma: description of a case and review of literature","internal_url":"https://www.academia.edu/17402712/Peritoneal_mesothelioma_description_of_a_case_and_review_of_literature","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487991,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487991/thumbnails/1.jpg","file_name":"Peritoneal_mesothelioma_description_of_a20151028-29725-6jj232.pdf","download_url":"https://www.academia.edu/attachments/39487991/download_file","bulk_download_file_name":"Peritoneal_mesothelioma_description_of_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487991/Peritoneal_mesothelioma_description_of_a20151028-29725-6jj232-libre.pdf?1446032916=\u0026response-content-disposition=attachment%3B+filename%3DPeritoneal_mesothelioma_description_of_a.pdf\u0026Expires=1740608699\u0026Signature=Ni4-aeOPxctAyLrdlpxooykz1~cjbar~Ik6K8AFn4-CQWVeadFLMcAQXFm3uuNfsAILHoJW~-cRIpewjdlhIr0ZPGbpz08mp0Prh699fZIjLCIoEVkn9uVGcmyRa~4mhYmCZN95B9KHtVBSZyb2R14t60mOcGYusCb1ql9h7732lcn0PF7L4-4qWXOO4ORotAiOQR4TqWhySzQB0jml2ADJH5Mnf~h~Pj11TLOUtH6QCZTxHzRK23iK1-TPQoixDPDq-xkDknGQS3P32RP18PqVtVrzunK67xu-ezeG1mvyGXkxoB9oPY36OksAgm-AlJzv14nHhNaxF9o~55~XIGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309275"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17309275/Exposure_to_heavy_metals_and_other_occupational_environmental_risk_agents_related_to_amyotrophic_lateral_sclerosis_a_review_of_literature"><img alt="Research paper thumbnail of Exposure to heavy metals and other occupational/environmental risk agents related to amyotrophic lateral sclerosis: a review of literature" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17309275/Exposure_to_heavy_metals_and_other_occupational_environmental_risk_agents_related_to_amyotrophic_lateral_sclerosis_a_review_of_literature">Exposure to heavy metals and other occupational/environmental risk agents related to amyotrophic lateral sclerosis: a review of literature</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NMiraglia">N. Miraglia</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>Giornale italiano di medicina del lavoro ed ergonomia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In recent years, scientific literature has been giving more and more importance to the study of t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In recent years, scientific literature has been giving more and more importance to the study of the occupational/environmental exposure to risk agents related to the onset of Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex. Aim of this work is to verify the state of art about the eventual role of occupational/environmental exposure to risk agents. Selected articles, on the basis of keywords, year of publication and topics, are related to occupational and environmental exposure to xenobiotics, and, in particular, to the exposure to heavy metals that could lead to neuronal damage mechanisms involved in ALS onset. The review shows that although the scientific production has increased the interest in the evaluation of extra-genetic causes of ALS onset, there are still few studies concerning the careful study of the work activities of the individual patien...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309275"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309275"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309275; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309275]").text(description); $(".js-view-count[data-work-id=17309275]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309275; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309275']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="17402711"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402711/Evaluation_by_environmental_monitoring_of_pesticide_absorption_in_farm_workers_of_18_Italian_tomato_cultivations"><img alt="Research paper thumbnail of Evaluation by environmental monitoring of pesticide absorption in farm workers of 18 Italian tomato cultivations" class="work-thumbnail" src="https://attachments.academia-assets.com/39487995/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402711/Evaluation_by_environmental_monitoring_of_pesticide_absorption_in_farm_workers_of_18_Italian_tomato_cultivations">Evaluation by environmental monitoring of pesticide absorption in farm workers of 18 Italian tomato cultivations</a></div><div class="wp-workCard_item"><span>International journal of immunopathology and pharmacology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tomato cultivation farms of Southern Italy were investigated in order to evaluate the general wor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tomato cultivation farms of Southern Italy were investigated in order to evaluate the general working conditions and the levels of exposure of farm workers to pesticides, during the mixing/loading and the application of pesticides on fields. Information on working modalities, personal protective equipment, etc. was collected using a questionnaire. Inhaling and cutaneous exposure levels were measured, and the estimated pesticide total absorbed dose was compared with Admissible Daily Intakes (ADIs). Field treatments were mainly carried out by using sprayers with open cab tractors, and, in 57.9 percent of cases, the pesticide mixture was manually prepared by mixing pesticides in a pail, often without using gloves (59.5 percent). The estimated pesticides absorbed doses varied in the range 0.56-2630.31 mg (mean value, 46.9 mg), and 20 percent of the measured absorbed doses exceeded ADIs. The findings obtained in the 18 examined farms show a worrying situation, suggesting the investigatio...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b946f4b95238113f2260dd5136de0bbb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487995,"asset_id":17402711,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487995/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402711"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402711"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402711; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402711]").text(description); $(".js-view-count[data-work-id=17402711]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402711; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402711']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402710"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402710/A_case_study_of_benzene_urinary_biomarkers_quantification_the_comparison_between_pre_and_postshift_samples_improves_the_interpretation_of_individual_biological_monitoring_data"><img alt="Research paper thumbnail of A case study of benzene urinary biomarkers quantification: the comparison between pre- and postshift samples improves the interpretation of individual biological monitoring data" class="work-thumbnail" src="https://attachments.academia-assets.com/39487941/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402710/A_case_study_of_benzene_urinary_biomarkers_quantification_the_comparison_between_pre_and_postshift_samples_improves_the_interpretation_of_individual_biological_monitoring_data">A case study of benzene urinary biomarkers quantification: the comparison between pre- and postshift samples improves the interpretation of individual biological monitoring data</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: benzene is an ubiquitous pollutant of working and living environments. Hence occupa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: benzene is an ubiquitous pollutant of working and living environments. Hence occupational prevention strategies need to discriminate between different exposure sources. The aim of the study is to take into account confounding factors in the evaluation of occupational exposure to benzene by biological monitoring (BM) investigations in small working realities. Materials and Methods: the BM of 14 workers of a refueling station was performed. Urinary benzene (UB) and trans, trans-muconic acid (t,t-MA) were used as biological markers. UB and t,t-MA determinations were performed by head space-solid phase microextraction followed by gas chromatography/mass spectrometry and High Performance Liquid Chromatography/UltraViolet detection. Urine collection was performed after work-shift (first BM campaign) as suggested by ACGIH. Subsequently, the urine collection was repeated before and after the work-shift (second BM campaign). Results: during the first BM campaign, contrasting results were found. Some workers showed low UB concentrations with respect to t,t-MA ones and vice versa, and although most subjects presented UB and t,t-MA levels below Biological Equivalents values and ACGIH's BEI, various exceptions were found. Biomarkers concentration decrements were observed by comparing pre-and post-shift samples (second BM campaign). Discussion: according to the ACGIH, the high biomarkers levels found in post-shift urine would suggest occupational exposure to benzene. Nevertheless, results obtained by monitoring post-shift urine only, without knowing individual background levels do not facilitate data interpretation. Findings from the second BM campaign suggest that biological monitoring strategies aimed to evaluate the occupational exposure of individuals to ubiquitous hazardous chemicals, need the measurement of biomarkers concentration both before and after the work-shift.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="84b2e8ea83e1d861d1b3e5ff765ffe1f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487941,"asset_id":17402710,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487941/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402710"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402710"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402710; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402710]").text(description); $(".js-view-count[data-work-id=17402710]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402710; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402710']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "84b2e8ea83e1d861d1b3e5ff765ffe1f" } } $('.js-work-strip[data-work-id=17402710]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402710,"title":"A case study of benzene urinary biomarkers quantification: the comparison between pre- and postshift samples improves the interpretation of individual biological monitoring data","internal_url":"https://www.academia.edu/17402710/A_case_study_of_benzene_urinary_biomarkers_quantification_the_comparison_between_pre_and_postshift_samples_improves_the_interpretation_of_individual_biological_monitoring_data","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487941,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487941/thumbnails/1.jpg","file_name":"A_case_study_of_benzene_urinary_biomarke20151028-10128-of6u0d.pdf","download_url":"https://www.academia.edu/attachments/39487941/download_file","bulk_download_file_name":"A_case_study_of_benzene_urinary_biomarke.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487941/A_case_study_of_benzene_urinary_biomarke20151028-10128-of6u0d-libre.pdf?1446032655=\u0026response-content-disposition=attachment%3B+filename%3DA_case_study_of_benzene_urinary_biomarke.pdf\u0026Expires=1740608699\u0026Signature=GY7Tj9SkJ5gdKsYNrV7h9bL~rQN8m7OyvKNcj6PHAkCqmI3RL63TMcinnpzQgQ7ew~CtVlFpXj9xy9cEJ-KfK-01w9BVo~0qyFtg8snzah1hdQCVYEr29lsQOk5hNsYtSY-lcTgaiWV6Kf-jyPPC~gqeRYH7S1X0wDrPR08Pc-7wGQvCs0cfQL95G~o5DAsmGqBg0mStmjFoZT7gD8UrMOiSVHtQmr5QVcvR9dO-4VMGTYr6VkE9jGyb2kBF2SjNPnFDusq7Tl2Q23GpwZwL6YJ5oKxwxtqryK2zHwK~ecnRj4GttAQjR5uT0QzEa7m-URlQj7hO-niOmBj1E0oH8w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402709"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402709/Using_the_Mini_Mental_State_Examination_MMSE_for_preliminary_assessment_of_cognitive_impairment_in_subjects_exposed_to_air_pollution_with_particulate_matter"><img alt="Research paper thumbnail of Using the Mini-Mental State Examination (MMSE) for preliminary assessment of cognitive impairment in subjects exposed to air pollution with particulate matter" class="work-thumbnail" src="https://attachments.academia-assets.com/39487984/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402709/Using_the_Mini_Mental_State_Examination_MMSE_for_preliminary_assessment_of_cognitive_impairment_in_subjects_exposed_to_air_pollution_with_particulate_matter">Using the Mini-Mental State Examination (MMSE) for preliminary assessment of cognitive impairment in subjects exposed to air pollution with particulate matter</a></div><div class="wp-workCard_item"><span>Giornale italiano di medicina del lavoro ed ergonomia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Epidemiologic and clinical studies have linked elevated concentrations of particulate matter to a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Epidemiologic and clinical studies have linked elevated concentrations of particulate matter to adverse health effects. In particular, has been demonstrated an association between UFPs exposure and occurrence of acute respiratory infections, lung cancer, chronic chronic obstructive pulmonary diseases and cardiovascular diseases. Recently, the exposure to particulate air pollution has been linked to cognitive decline. In this work, we used the Mini-Mental State Examination (MMSE) in a preliminary assessment of cognitive function in individuals who have lived and carried out work in heavily urbanized areas, where ambient levels of particulate air pollution were frequently above the standard of the law. The results showed the presence of mild-moderate cognitive impairment in 39.4% of the subjects examined compared to the control group.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="83f412156529abf6cb37cea4db6ef598" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487984,"asset_id":17402709,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487984/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402709"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402709"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402709; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402709]").text(description); $(".js-view-count[data-work-id=17402709]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402709; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402709']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "83f412156529abf6cb37cea4db6ef598" } } $('.js-work-strip[data-work-id=17402709]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402709,"title":"Using the Mini-Mental State Examination (MMSE) for preliminary assessment of cognitive impairment in subjects exposed to air pollution with particulate matter","internal_url":"https://www.academia.edu/17402709/Using_the_Mini_Mental_State_Examination_MMSE_for_preliminary_assessment_of_cognitive_impairment_in_subjects_exposed_to_air_pollution_with_particulate_matter","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487984,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487984/thumbnails/1.jpg","file_name":"Using_the_Mini-Mental_State_Examination_20151028-29725-5bcym8.pdf","download_url":"https://www.academia.edu/attachments/39487984/download_file","bulk_download_file_name":"Using_the_Mini_Mental_State_Examination.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487984/Using_the_Mini-Mental_State_Examination_20151028-29725-5bcym8-libre.pdf?1446032920=\u0026response-content-disposition=attachment%3B+filename%3DUsing_the_Mini_Mental_State_Examination.pdf\u0026Expires=1740608699\u0026Signature=Kc5ZMBzRD1W6Hfe-T4ygmvCVI6Yd6TE~Z0goS4C2l1V8Ir7sECrFwiKNZKJSeq2zsu2mJMmc5b36saq9NI6hadGZS11NHM~8V4CzP4BfSbcIOjezETiswJinClGQh-g8iEQFvQuANjL~RMlar~mWiDqyFogq3tFvhmmFEv0xe5yrvn9zh2EFrKNmMN3LG5p9SGFLi1IenywdcRYXGTpydj1vf7VQDY7odBFNQmVYUxm3X3DH-M5j68u56-f4SAvlWdJ5uBMtCclBYY8~4SWmLMrFfp2fxSaHgZRvu~yRhNu3TLQl0K97RHTT2~gw8JN5yFlErgZDuqL-stXNOJzyLQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309270"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17309270/Working_Conditions_and_Mental_Health_Results_from_the_CARESUN_Study"><img alt="Research paper thumbnail of Working Conditions and Mental Health: Results from the CARESUN Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17309270/Working_Conditions_and_Mental_Health_Results_from_the_CARESUN_Study">Working Conditions and Mental Health: Results from the CARESUN Study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>Archives of Environmental & Occupational Health</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We conducted a work-related stress surveillance study in 2013 on 6558 public-sector employees in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We conducted a work-related stress surveillance study in 2013 on 6558 public-sector employees in Italy, examining how they perceived their jobs, via the Job Content Questionnaire, and their mental health status, via the General Health Questionnaire 12 (GHQ-12). Of the 2094 employees completing the questionnaires, 60% were male, 52% had a medium-level education, and 76% had a medium-level job. Three hundred and eighty-five employees (18%) had a GHQ-12 score &amp;amp;amp;gt;3 and were classified as GHQ-12 cases: these were more often female (54%), medium-to-highly educated (54%), and had more often reported health problems over the previous year (51%). Thus, GHQ-12 cases represented a significant percentage of our examined population, indicating that work-related stress surveillance programs are needed for the planning of psychosocial interventions aimed at the reintegration of individuals with mental health problems.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309270"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309270"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309270; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309270]").text(description); $(".js-view-count[data-work-id=17309270]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309270; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309270']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17309270]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17309270,"title":"Working Conditions and Mental Health: Results from the CARESUN Study","internal_url":"https://www.academia.edu/17309270/Working_Conditions_and_Mental_Health_Results_from_the_CARESUN_Study","owner_id":36993140,"coauthors_can_edit":true,"owner":{"id":36993140,"first_name":"Nicola","middle_initials":null,"last_name":"Sannolo","page_name":"NicolaSannolo","domain_name":"unina2","created_at":"2015-10-26T08:29:18.139-07:00","display_name":"Nicola Sannolo","url":"https://unina2.academia.edu/NicolaSannolo"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402708"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402708/Engineered_metal_based_nanoparticles_and_innate_immunity"><img alt="Research paper thumbnail of Engineered metal based nanoparticles and innate immunity" class="work-thumbnail" src="https://attachments.academia-assets.com/39487937/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402708/Engineered_metal_based_nanoparticles_and_innate_immunity">Engineered metal based nanoparticles and innate immunity</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unich-it.academia.edu/enricosabbioni">enrico sabbioni</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unich-it.academia.edu/RobertoPaganelli">Roberto Paganelli</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://en-unich.academia.edu/MarioDiGioacchino">Mario Di Gioacchino</a></span></div><div class="wp-workCard_item"><span>Clinical and Molecular Allergy</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Almost all people in developed countries are exposed to metal nanoparticles (MeNPs) that are used...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Almost all people in developed countries are exposed to metal nanoparticles (MeNPs) that are used in a large number of applications including medical (for diagnostic and therapeutic purposes). Once inside the body, absorbed by inhalation, contact, ingestion and injection, MeNPs can translocate to tissues and, as any foreign substance, are likely to encounter the innate immunity system that represent a non-specific first line of defense against potential threats to the host. In this review, we will discuss the possible effects of MeNPs on various components of the innate immunity (both specific cells and barriers). Most important is that there are no reports of immune diseases induced by MeNPs exposure: we are operating in a safe area. However, in vitro assays show that MeNPs have some effects on innate immunity, the main being toxicity (both cyto-and genotoxicity) and interference with the activity of various cells through modification of membrane receptors, gene expression and cytokine production. Such effects can have both negative and positive relevant impacts on humans. On the one hand, people exposed to high levels of MeNPs, as workers of industries producing or applying MeNPs, should be monitored for possible health effects. On the other hand, understanding the modality of the effects on immune responses is essential to develop medical applications for MeNPs. Indeed, those MeNPs that are able to stimulate immune cells could be used to develop of new vaccines, promote immunity against tumors and suppress autoimmunity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f151523305f29fd7a39cd4ef11724ce" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487937,"asset_id":17402708,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487937/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402708"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402708]").text(description); $(".js-view-count[data-work-id=17402708]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402708']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f151523305f29fd7a39cd4ef11724ce" } } $('.js-work-strip[data-work-id=17402708]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402708,"title":"Engineered metal based nanoparticles and innate immunity","internal_url":"https://www.academia.edu/17402708/Engineered_metal_based_nanoparticles_and_innate_immunity","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487937,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487937/thumbnails/1.jpg","file_name":"Engineered_metal_based_nanoparticles_and20151028-28426-1dnq89k.pdf","download_url":"https://www.academia.edu/attachments/39487937/download_file","bulk_download_file_name":"Engineered_metal_based_nanoparticles_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487937/Engineered_metal_based_nanoparticles_and20151028-28426-1dnq89k-libre.pdf?1446032656=\u0026response-content-disposition=attachment%3B+filename%3DEngineered_metal_based_nanoparticles_and.pdf\u0026Expires=1740131996\u0026Signature=Lj7qdKx~b~wUPz0lJzLU5F8j454cFPOW5GBS7etyIkS2plwB6CxKmQE9RtfR1EVT3gPATmnCsVo0A7LxEGhF8Qh2j~IaIrhZ0MFoZIPRCoYBrJ7aeG4Tf8nU3iROBspQ3s84jS95KgfiUKEo5EisFeqLWTVefpCtk9Bqbo-GTgWA-H8JPeuUZp2IZL0Ayh0iyChEgnXc-ahg0XJ10FFMVTAwReg4ScA26LEQaLwKK6CHr1iem3kKaHBa-2yNAykjv6s59ZsN2n3vusNNwxnJZbJUT0O63qcYx3FyW32rTsOLS32mE4rOfS90DckpprvHoq~8MISWkC2Qsrfr6v2NJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309268"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309268/_Human_health_effects_of_ultrafine_particles_"><img alt="Research paper thumbnail of [Human health effects of ultrafine particles]" class="work-thumbnail" src="https://attachments.academia-assets.com/39437946/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309268/_Human_health_effects_of_ultrafine_particles_">[Human health effects of ultrafine particles]</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>Giornale italiano di medicina del lavoro ed ergonomia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Epidemiologic and clinical studies have linked elevated concentrations of ambient ultrafine parti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Epidemiologic and clinical studies have linked elevated concentrations of ambient ultrafine particles (UFPs) to adverse health effects. In particular, has been demonstrated an association between UFPs exposure and occurrence of acute respiratory infections, lung cancer, chronic chronic obstructive pulmonary diseases and cardiovascular diseases. Although the biological mechanisms behind these associations are not fully understood, the results of in vitro toxicological research have shown that UFPs induces several types of adverse cellular effects, including cytotoxicity, mutagenicity, DNA oxidative damage and stimulation of proinflammatory cytokine production. In this reviewer are summarized the results of the recent epidemiological and toxicological studies on adverse health effects from exposure to UFPs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="57b621fa3768fb954e306109ace71896" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39437946,"asset_id":17309268,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39437946/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309268"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309268"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309268; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309268]").text(description); $(".js-view-count[data-work-id=17309268]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309268; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309268']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "57b621fa3768fb954e306109ace71896" } } $('.js-work-strip[data-work-id=17309268]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17309268,"title":"[Human health effects of ultrafine particles]","internal_url":"https://www.academia.edu/17309268/_Human_health_effects_of_ultrafine_particles_","owner_id":36993140,"coauthors_can_edit":true,"owner":{"id":36993140,"first_name":"Nicola","middle_initials":null,"last_name":"Sannolo","page_name":"NicolaSannolo","domain_name":"unina2","created_at":"2015-10-26T08:29:18.139-07:00","display_name":"Nicola Sannolo","url":"https://unina2.academia.edu/NicolaSannolo"},"attachments":[{"id":39437946,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39437946/thumbnails/1.jpg","file_name":"Human_health_effects_of_ultrafine_partic20151026-32577-1qzzh56.pdf","download_url":"https://www.academia.edu/attachments/39437946/download_file","bulk_download_file_name":"Human_health_effects_of_ultrafine_parti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39437946/Human_health_effects_of_ultrafine_partic20151026-32577-1qzzh56-libre.pdf?1445895572=\u0026response-content-disposition=attachment%3B+filename%3DHuman_health_effects_of_ultrafine_parti.pdf\u0026Expires=1740608699\u0026Signature=abPTN53KRkquhpKgUO8NJw-wcAuByMuIK1KJiqQOwhsB2QetUp7gsEtx~Udca6JsT1EjHkAA5m4aFYnkUqvsBpq6tG5plHy9AARibyzVZBhNhWUXzpnYH-QzuLG3py0VB8iY4JshXGWX-pSt1TxYMerYYjm~s9H9DUZ0vOFlpRpuFpTXWj84WFG2~nXncyH8K~ZHaSVTGs46mzZVq1jKPxfTKHiNcTiWqmRKvWWe2k1uhB6Ng-jUAPDMQ8EGtuGjpuZyjN~IKYhY9MBMCoVhmRXxYzcULm2IiTlbdspldCFVsfMm3knZOrd2B87gOmrTOObONKvW4PQGio~7b0RG5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309267"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309267/Carbon_nanotubes_Properties_biomedical_applications_advantages_and_risks_in_patients_and_occupationally_exposed_workers"><img alt="Research paper thumbnail of Carbon nanotubes: Properties, biomedical applications, advantages and risks in patients and occupationally-exposed workers" class="work-thumbnail" src="https://attachments.academia-assets.com/39437944/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309267/Carbon_nanotubes_Properties_biomedical_applications_advantages_and_risks_in_patients_and_occupationally_exposed_workers">Carbon nanotubes: Properties, biomedical applications, advantages and risks in patients and occupationally-exposed workers</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>International journal of immunopathology and pharmacology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced in pharmacy and medicine for drug delivery system in therapeutics. CNTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomedical applications such as advanced imaging, tissue regeneration, and drug or gene delivery. Although there are many data on the advantages in terms of higher efficacy and less adverse effects, several recent findings have reported unexpected toxicities induced by CNTs. The dose, shape, surface chemistry, exposure route, and purity play important roles in these differential toxicities. Mapping these risks as well as understanding their molecular mechanisms is a crucial step in the development of any CNT-containing nanopharmaceuticals. This paper seeks to provide a comprehensive review of all articles published on cellular response to CNTs, underlining their therapeutic a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bba2b5e23433f4b315ff0b0cbe44c179" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39437944,"asset_id":17309267,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39437944/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309267"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309267"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309267; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309263"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309263/Blood_Lead_Manganese_and_Aluminum_Levels_in_a_Regional_Italian_Cohort_of_ALS_Patients"><img alt="Research paper thumbnail of Blood Lead, Manganese, and Aluminum Levels in a Regional Italian Cohort of ALS Patients" class="work-thumbnail" src="https://attachments.academia-assets.com/41904370/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309263/Blood_Lead_Manganese_and_Aluminum_Levels_in_a_Regional_Italian_Cohort_of_ALS_Patients">Blood Lead, Manganese, and Aluminum Levels in a Regional Italian Cohort of ALS Patients</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NMiraglia">N. Miraglia</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElpidioGarzillo">Elpidio Garzillo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LucaDaniele1">Luca Daniele</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MariaMonsurro">Maria Monsurro</a></span></div><div class="wp-workCard_item"><span>Journal of Occupational and Environmental Medicine</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae37bca3ce300dda2a1b0b0b384af2f7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41904370,"asset_id":17309263,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41904370/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309263"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309263"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309263; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309263]").text(description); $(".js-view-count[data-work-id=17309263]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309263; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309263']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ae37bca3ce300dda2a1b0b0b384af2f7" } } $('.js-work-strip[data-work-id=17309263]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17309263,"title":"Blood Lead, Manganese, and Aluminum Levels in a Regional Italian Cohort of ALS Patients","internal_url":"https://www.academia.edu/17309263/Blood_Lead_Manganese_and_Aluminum_Levels_in_a_Regional_Italian_Cohort_of_ALS_Patients","owner_id":36993140,"coauthors_can_edit":true,"owner":{"id":36993140,"first_name":"Nicola","middle_initials":null,"last_name":"Sannolo","page_name":"NicolaSannolo","domain_name":"unina2","created_at":"2015-10-26T08:29:18.139-07:00","display_name":"Nicola Sannolo","url":"https://unina2.academia.edu/NicolaSannolo"},"attachments":[{"id":41904370,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41904370/thumbnails/1.jpg","file_name":"Blood_Lead_Manganese_and_Aluminum_Levels20160202-30232-541ks1.pdf","download_url":"https://www.academia.edu/attachments/41904370/download_file","bulk_download_file_name":"Blood_Lead_Manganese_and_Aluminum_Levels.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41904370/Blood_Lead_Manganese_and_Aluminum_Levels20160202-30232-541ks1-libre.pdf?1454454259=\u0026response-content-disposition=attachment%3B+filename%3DBlood_Lead_Manganese_and_Aluminum_Levels.pdf\u0026Expires=1740608657\u0026Signature=Ul~ZFLI4RiA2P1CQShtfUX1I3Tl3pLCtyLKfnKGNe128voWml3TGNnQZA3d-Ic83YY1mkmyxdILmUMK0MI4nAseTS2rD5Y09B2~y-7MlSzUCGOyVuR92u0IMfMdepSKQyZg-4Gt242O3oedMt1R-ZA7Awc~NIbQNwCfcKPAbOJcj9LYoN~ms~ez7GykHF2XNbUMW4~fHuFYFZY0LmPDeoCpXGffInD~kQFOTe5A~DrqZ~ChhGlcOkk~QUHsm6xd06q~NQrDkDPj-e-~ngcYITytYCfrVwIPxls9W~leZ4qfTEmol9fPkeYK4L95sIobQDcub0zOVkvKNflWfsa3Ihg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402707"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402707/Carbon_TiO2_Nanostructures_Flame_Synthesis_and_Characterization"><img alt="Research paper thumbnail of Carbon-TiO2 Nanostructures: Flame Synthesis and Characterization" class="work-thumbnail" src="https://attachments.academia-assets.com/41890057/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402707/Carbon_TiO2_Nanostructures_Flame_Synthesis_and_Characterization">Carbon-TiO2 Nanostructures: Flame Synthesis and Characterization</a></div><div class="wp-workCard_item"><span>MRS Proceedings</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The synthesis of pure titania and carbon-titania nano-powders in a premixed atmospheric fuel-rich...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The synthesis of pure titania and carbon-titania nano-powders in a premixed atmospheric fuel-rich flame was studied. The variation of the flame C/O ratio allows to produce both pure titania and carbon-TiO 2 nanoparticles. Raman Spectroscopy, X-ray Diffraction, Atomic Force Microscopy, Electrical Low Pressure Impactor and Scanning Electron Microscopy were used to characterize the synthesized nano-powders, in terms of crystallinity, phase content, size and morphology. Produced nano-powders with a dimension of 25-40 nm are composed by both rutile and anatase phases, with rutile being the predominant one. Reactive Oxygen Species analysis performed on the synthesized nano-powders showed that the inclusion of carbon in the nanopowders results in a reduced adverse health effect, in terms of ROS production.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dd79b43791d68cf1343385b77f702216" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41890057,"asset_id":17402707,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41890057/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402707"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402707"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402707; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402707]").text(description); $(".js-view-count[data-work-id=17402707]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402707; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402707']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dd79b43791d68cf1343385b77f702216" } } $('.js-work-strip[data-work-id=17402707]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402707,"title":"Carbon-TiO2 Nanostructures: Flame Synthesis and Characterization","internal_url":"https://www.academia.edu/17402707/Carbon_TiO2_Nanostructures_Flame_Synthesis_and_Characterization","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":41890057,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41890057/thumbnails/1.jpg","file_name":"Carbon-TiO2_Nanostructures_Flame_Synthes20160202-30232-rzxxi4.pdf","download_url":"https://www.academia.edu/attachments/41890057/download_file","bulk_download_file_name":"Carbon_TiO2_Nanostructures_Flame_Synthes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41890057/Carbon-TiO2_Nanostructures_Flame_Synthes20160202-30232-rzxxi4-libre.pdf?1454427040=\u0026response-content-disposition=attachment%3B+filename%3DCarbon_TiO2_Nanostructures_Flame_Synthes.pdf\u0026Expires=1740608699\u0026Signature=aiJF1D2kRUmhv59QJWokQNQLTpao7IX4hpSfR2XnmuRRTXWDR6yNW4jtY3D0zdkj7nJyPIc3IdFulME7F0tT670OjgOQCcEcHFLPk1k~IkzpTqp9I-xG5a3Y1DWeFmbhr3T6VoGbxycIIiVFRSLsJ~0O1fbUT1poADJThy5hvtpfz7tT3YN5-YKaACDVFD6UPD0SEOlmE-UWrDTLHfuSR82jsq1gISd2r1UfsQn7klQfTRxHn5MAngFmFSph5QZj82L5SdwM5hJ8boWf3wZKmqSHo~qfFIRMnSjWkU8IOv2bNozw~3jfkedhcU3lpkiZnvr2ZrxJOd1Mk1L37fUocw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309256"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17309256/Doxorubicin_can_penetrate_nitrile_gloves_and_induces_apoptosis_in_keratinocytes_cell_lines"><img alt="Research paper thumbnail of Doxorubicin can penetrate nitrile gloves and induces apoptosis in keratinocytes cell lines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17309256/Doxorubicin_can_penetrate_nitrile_gloves_and_induces_apoptosis_in_keratinocytes_cell_lines">Doxorubicin can penetrate nitrile gloves and induces apoptosis in keratinocytes cell lines</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NMiraglia">N. Miraglia</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a></span></div><div class="wp-workCard_item"><span>Toxicology Letters</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Doxorubicin (DOXO) is an anthracycline antibiotic which is used in the treatment of human maligna...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Doxorubicin (DOXO) is an anthracycline antibiotic which is used in the treatment of human malignancies such as leukemia, lymphoma and a number of solid tumors, particularly breast cancer. Anthracyclines have been reported to contaminate chemotherapy workstation surfaces as well as other workplaces surfaces. The occupational exposure to these drugs could occur in hospitals, for nurses involved in anthracyclines preparation and administration, in chemical industries during the commercial formulate syntheses, and in analytical laboratories. Numerous studies investigated cutaneous effects related to DOXO administration, on the contrary few literature data are available about effects on the skin due to the direct contact with the drug. The present study investigated the DOXO permeability of three commercially available gloves&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; types used to protect skin in occupational contexts, as well as the effects of DOXO on human keratinocyte cell line (HaCaT). The results suggest that the DOXO permeability of gloves depends not only on glove material but also on DOXO solutions&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; pH, in fact nitrile gloves can be penetrated by acid solutions, while neither natural rubbers nor nitrile gloves are permeable to neutral solutions. Moreover, DOXO solutions, even at low concentration, cause apoptosis in epithelial cells, through activation of intrinsic pathway p53-independent.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309256"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309256"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309256; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17309255]").text(description); $(".js-view-count[data-work-id=17309255]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17309255; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17309255']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f624bf175596de14f36423855ea148d" } } $('.js-work-strip[data-work-id=17309255]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17309255,"title":"Apoptotic and proinflammatory effect of combustion-generated organic nanoparticles in endothelial cells","internal_url":"https://www.academia.edu/17309255/Apoptotic_and_proinflammatory_effect_of_combustion_generated_organic_nanoparticles_in_endothelial_cells","owner_id":36993140,"coauthors_can_edit":true,"owner":{"id":36993140,"first_name":"Nicola","middle_initials":null,"last_name":"Sannolo","page_name":"NicolaSannolo","domain_name":"unina2","created_at":"2015-10-26T08:29:18.139-07:00","display_name":"Nicola Sannolo","url":"https://unina2.academia.edu/NicolaSannolo"},"attachments":[{"id":41904075,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41904075/thumbnails/1.jpg","file_name":"Apoptotic_and_proinflammatory_effect_of_20160202-30232-lwp540.pdf","download_url":"https://www.academia.edu/attachments/41904075/download_file","bulk_download_file_name":"Apoptotic_and_proinflammatory_effect_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41904075/Apoptotic_and_proinflammatory_effect_of_20160202-30232-lwp540-libre.pdf?1454453901=\u0026response-content-disposition=attachment%3B+filename%3DApoptotic_and_proinflammatory_effect_of.pdf\u0026Expires=1740608699\u0026Signature=P0OwS-nGxQxlraHyhA7gVgtkBtSUsTPg1K-O5qpZ1pVsGpAgAJtTCiVEm3uOWtMk71IeHRsR4nLQd9YF1CeCAx71c0v6wVs3sXYawhk10290~mlomMyMvcO~Fteh5heR-8iHOtoW3XG-J5aeMd9iaPJQq4qaLwArzit~SDXFbgBQmbnoEMiykzQP0jlrACQIAtJP11wB2neJqwgz3PSrdrPu36adXuSyVJQR2iNaj-tut-6j6k3krv0HspdUss6l-Ya7wtZSEb8BzvXLC524QXixEqH0e7jU745umLpfV28sHZbCUMqEC-82Q7OmgiGzIUYkDuZaOL5jdh1InDzSXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402706"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402706/Interaction_between_combustion_generated_organic_nanoparticles_and_biological_systems_In_vitro_study_of_cell_toxicity_and_apoptosis_in_human_keratinocytes"><img alt="Research paper thumbnail of Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes" class="work-thumbnail" src="https://attachments.academia-assets.com/39487935/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402706/Interaction_between_combustion_generated_organic_nanoparticles_and_biological_systems_In_vitro_study_of_cell_toxicity_and_apoptosis_in_human_keratinocytes">Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/patriziaminutolo">patrizia minutolo</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a></span></div><div class="wp-workCard_item"><span>Nanotoxicology</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eaf2cb2cdb5597a656af51bf9c7495f1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487935,"asset_id":17402706,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487935/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402706"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402706"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402706; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17402706]").text(description); $(".js-view-count[data-work-id=17402706]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17402706; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17402706']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eaf2cb2cdb5597a656af51bf9c7495f1" } } $('.js-work-strip[data-work-id=17402706]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17402706,"title":"Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes","internal_url":"https://www.academia.edu/17402706/Interaction_between_combustion_generated_organic_nanoparticles_and_biological_systems_In_vitro_study_of_cell_toxicity_and_apoptosis_in_human_keratinocytes","owner_id":37126197,"coauthors_can_edit":true,"owner":{"id":37126197,"first_name":"Paola","middle_initials":null,"last_name":"Pedata","page_name":"PaolaPedata","domain_name":"independent","created_at":"2015-10-28T02:28:26.614-07:00","display_name":"Paola Pedata","url":"https://independent.academia.edu/PaolaPedata"},"attachments":[{"id":39487935,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39487935/thumbnails/1.jpg","file_name":"Interaction_between_combustion-generated20151028-28426-1s6lzcw.pdf","download_url":"https://www.academia.edu/attachments/39487935/download_file","bulk_download_file_name":"Interaction_between_combustion_generated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39487935/Interaction_between_combustion-generated20151028-28426-1s6lzcw-libre.pdf?1446032657=\u0026response-content-disposition=attachment%3B+filename%3DInteraction_between_combustion_generated.pdf\u0026Expires=1740608699\u0026Signature=CNgpDzVGDkVjjvf9aLhZctrFCcaKsZ2YOyzE2Jks-87bMIk5Cc3DTof-do1KuA74CnrrOUXxDHYR91VQ7NmYY8B52AOLMbZ1oFyjP0KAJMPK7ut7dkiuOLtHtvo70juejpqzuAv-GLKA5dUctmF9InQMYHeMzn9aitbJdg0iBPDCneB4qO0QPsvG9i5YTekIQxi4GEhZEcQG7KMEftd8XllzHUxnUBeWlnrRp-J473e0~qsmAr3Ej7KMjtPE-FzQc-gMDqxTElUfC2EujX67Qtbvc8RHfs13HHFsNVN2H4kPPOVzVBRDydZSXidXrAIOMLXX34JYYpepHkr4USL3xA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17402705"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17402705/Epirubicin_permeation_of_personal_protective_equipment_can_induce_apoptosis_in_keratinocytes"><img alt="Research paper thumbnail of Epirubicin permeation of personal protective equipment can induce apoptosis in keratinocytes" class="work-thumbnail" src="https://attachments.academia-assets.com/39487981/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17402705/Epirubicin_permeation_of_personal_protective_equipment_can_induce_apoptosis_in_keratinocytes">Epirubicin permeation of personal protective equipment can induce apoptosis in keratinocytes</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a></span></div><div class="wp-workCard_item"><span>Journal of Exposure Science and Environmental Epidemiology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study investigated the epirubicin (EPI) permeability of various commercially availabl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study investigated the epirubicin (EPI) permeability of various commercially available glove types, as well as toxicity mechanisms and effects on human keratinocyte cell line (HaCaT). Permeability experiments were carried out on various commercially available gloves, differing as regards material and thickness. Permeability was evaluated after different ''contact times'' and the influence of EPI solution's pH (acid and neutral) on permeability was also examined. Toxicity of EPI toward skin was tested by evaluating the effects of the drug on cell growth and apoptosis, by using an in vitro model based on cultured immortalized human keratinocytes. No permeation was detected in the case of EPI neutral solutions; in contrast, acid solutions were found to penetrate low thickness nitrile gloves. Obtained results also showed the induction of apoptosis in epithelial cells through the activation of intrinsic pathway p53-independent occurring even when cells are exposed at low drug concentration. EPI solution's pH influences the glove's permeability; once penetrated, EPI at concentrations lower than those able to penetrate the nitrile glove during the 8-h work-shift can cause apoptosis in epithelial cells. The findings reported here highly support the choice of either natural rubbers gloves or high thickness nitrile ones for preventing the occupational exposure to EPI Q2 .</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="73134e3ac917f7a00ab252cdb3bd6463" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39487981,"asset_id":17402705,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39487981/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17402705"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17402705"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17402705; 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Miraglia</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElpidioGarzillo">Elpidio Garzillo</a>, and <a class="" data-click-track="profile-work-strip-authors" rel="nofollow" href="https://independent.academia.edu/RosarioMiranda1">Rosario Miranda</a></span></div><div class="wp-workCard_item"><span>International Journal of Environmental Health Research</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3462362ad001f07d45ccde014385e7ce" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39437931,"asset_id":17309241,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39437931/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17309241"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17309241"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17309241; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17309282"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17309282/Ultrafine_particles_and_effects_on_the_organism_Literature_review"><img alt="Research paper thumbnail of Ultrafine particles and effects on the organism: Literature review" class="work-thumbnail" src="https://attachments.academia-assets.com/39437950/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17309282/Ultrafine_particles_and_effects_on_the_organism_Literature_review">Ultrafine particles and effects on the organism: Literature review</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PaolaPedata">Paola Pedata</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unina2.academia.edu/NicolaSannolo">Nicola Sannolo</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElpidioGarzillo">Elpidio Garzillo</a></span></div><div class="wp-workCard_item"><span>Giornale italiano di medicina del lavoro ed ergonomia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Negli ultimi anni, l'interesse della comunità scientifica internazionale nel campo della ricerca ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Negli ultimi anni, l'interesse della comunità scientifica internazionale nel campo della ricerca si è incentrato sullo studio degli effetti del particolato ultrafine sulla salute umana. Le particelle ultrafini (PM 0.1 : diametro aerodinamico medio inferiore a 0.1 µm) sono complesse miscele di sostanze organiche ed inorganiche, dotate di intrinseca tossicità. 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